|
Name |
Accession |
Description |
Interval |
E-value |
| MoeA |
COG0303 |
Molybdopterin Mo-transferase (molybdopterin biosynthesis) [Coenzyme transport and metabolism]; ... |
41-439 |
7.70e-132 |
|
Molybdopterin Mo-transferase (molybdopterin biosynthesis) [Coenzyme transport and metabolism]; Molybdopterin Mo-transferase (molybdopterin biosynthesis) is part of the Pathway/BioSystem: Molybdopterin biosynthesis
Pssm-ID: 440072 [Multi-domain] Cd Length: 401 Bit Score: 385.60 E-value: 7.70e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 41 RSVADHRQAVRELLEPLlsreRTELLPLVQALGRGLAEDITAPLSLPPFPNSQMDGFAIRSGDVPDGG-TSLRVAAPVPA 119
Cdd:COG0303 2 ISVEEALALILAAVRPL----GTETVPLAEALGRVLAEDVVAPRDVPPFDNSAMDGYAVRAADLAGANpVTLRVVGEIAA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 120 G-ASPAPLEPGTAVPIMTGAMLPAGADAVVPIEQAlpsvfpaAGEEAEVRLPAT-AAGTFVRAVGSDIAAGQQALAAGTC 197
Cdd:COG0303 78 GsPPPGPLGPGEAVRIMTGAPLPEGADAVVMQEDT-------EREGDRVTIRKPvAPGENIRRAGEDIAAGDVLLPAGTR 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 198 LGPAQLGLLAALGLPEVLVHKQLSVLLVTTGDEVVEPGEPLGDGKIYDANGTLLESALRQAGLAVTRAGISADSPEALRA 277
Cdd:COG0303 151 LTPADLGLLASLGIAEVPVYRRPRVAILSTGDELVEPGEPLGPGQIYDSNSYMLAALLREAGAEVVDLGIVPDDPEALRA 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 278 LLRSHTSAVDLIVSTGGVSKGAYEVVRQAMD--GQDVTFGHVAMQPGGPQGLGRFDGVPLLAFPGNPVSCLVSFEMFLRP 355
Cdd:COG0303 231 ALREALAEADLVITSGGVSVGDYDLVKEALEelGAEVLFHKVAMKPGKPLAFGRLGGKPVFGLPGNPVSALVTFELFVRP 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 356 VLGELFGAPAP-RPAVRARLAQPLSSPAGKHQVRRGSL---QGDGTVRLQGGESSHLVQALAHSNALVHVPAGTAVLNEG 431
Cdd:COG0303 311 ALRKLAGLPPPpPPRVRARLAEDLPKKPGRTEFLRVRLerdDGELVVEPLGGQGSGLLSSLAEADGLIVLPEGVEGVEAG 390
|
....*...
gi 1134500782 432 AEVEVWML 439
Cdd:COG0303 391 EEVEVLLL 398
|
|
| MoeA |
cd00887 |
MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor ... |
48-439 |
6.73e-128 |
|
MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MoeA, together with MoaB, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes.
Pssm-ID: 238452 [Multi-domain] Cd Length: 394 Bit Score: 375.29 E-value: 6.73e-128
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 48 QAVRELLEPLLSRERTELLPLVQALGRGLAEDITAPLSLPPFPNSQMDGFAIRSGDVPDGGTSLRVAAPVPAGASPA-PL 126
Cdd:cd00887 2 EAARELLLALAPPLGTETVPLLEALGRVLAEDVVAPIDLPPFDNSAMDGYAVRAADTAGASVTLRVVGEIPAGEPPDgPL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 127 EPGTAVPIMTGAMLPAGADAVVPIEQAlpsvfpaAGEEAEVRLPATA-AGTFVRAVGSDIAAGQQALAAGTCLGPAQLGL 205
Cdd:cd00887 82 GPGEAVRIMTGAPLPEGADAVVMVEDT-------EEEGGRVTITKPVkPGQNIRRAGEDIKAGDVLLPAGTRLTPADIGL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 206 LAALGLPEVLVHKQLSVLLVTTGDEVVEPGEPLGDGKIYDANGTLLESALRQAGLAVTRAGISADSPEALRALLRSHTSA 285
Cdd:cd00887 155 LASLGIAEVPVYRRPRVAIISTGDELVEPGEPLAPGQIYDSNSYMLAALLRELGAEVVDLGIVPDDPEALREALEEALEE 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 286 VDLIVSTGGVSKGAYEVVRQAMD--GQDVTFGHVAMQPGGPQGLGRFDGVPLLAFPGNPVSCLVSFEMFLRPVLGELFGA 363
Cdd:cd00887 235 ADVVITSGGVSVGDYDFVKEVLEelGGEVLFHGVAMKPGKPLAFGRLGGKPVFGLPGNPVSALVTFELFVRPALRKLQGA 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 364 PAPRPA-VRARLAQPLSSPAGKHQVRRGSLQ---GDGTVRLQGGESSHLVQALAHSNALVHVPAGTAVLNEGAEVEVWML 439
Cdd:cd00887 315 PEPEPPrVKARLAEDLKSKPGRREFLRVRLErdeGGLVVAPPGGQGSGLLSSLARADGLIVIPEGVEGLEAGEEVEVLLL 394
|
|
| PRK14498 |
PRK14498 |
putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing ... |
42-439 |
4.24e-81 |
|
putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional
Pssm-ID: 237732 [Multi-domain] Cd Length: 633 Bit Score: 262.46 E-value: 4.24e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 42 SVADHRQAVRELLEPLlsRERTELLPLVQALGRGLAEDITAPLSLPPFPNSQMDGFAIRSGDVPDGGTS----LRVAAPV 117
Cdd:PRK14498 11 SLEEAREILESLLSEL--PLGTEEVPLEEALGRVLAEDVYAPIDVPPFDRSAMDGYAVRAADTFGASEAnpvrLKLGGEV 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 118 PAGASPA-PLEPGTAVPIMTGAMLPAGADAVVPIEQalpsVFPAAGEEAEVRLPAtAAGTFVRAVGSDIAAGQQALAAGT 196
Cdd:PRK14498 89 HAGEAPDvEVEPGEAVEIATGAPIPRGADAVVMVED----TEEVDDDTVEIYRPV-APGENVRPAGEDIVAGELILPKGT 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 197 CLGPAQLGLLAALGLPEVLVHKQLSVLLVTTGDEVVEPGEPLGDGKIYDANGTLLESALRQAGLAVTRAGISADSPEALR 276
Cdd:PRK14498 164 RLTPRDIGALAAGGVAEVPVYKKPRVGIISTGDELVEPGEPLKPGKIYDVNSYTLAAAVEEAGGEPVRYGIVPDDEEELE 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 277 ALLRSHTSAVDLIVSTGGVSKGAYEVVRQAMDGQDVTFGH-VAMQPGGPQGLGRFDGVPLLAFPGNPVSCLVSFEMFLRP 355
Cdd:PRK14498 244 AALRKALKECDLVLLSGGTSAGAGDVTYRVIEELGEVLVHgVAIKPGKPTILGVIGGKPVVGLPGYPVSALTIFEEFVAP 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 356 VLGELFGAPAPRPA-VRARLAQPLSSPAGKHQVRRGSL--QGDGTVRLQGGESSHLVQALAHSNALVHVPAGTAVLNEGA 432
Cdd:PRK14498 324 LLRKLAGLPPPERAtVKARLARRVRSELGREEFVPVSLgrVGDGYVAYPLSRGSGAITSLVRADGFIEIPANTEGLEAGE 403
|
....*..
gi 1134500782 433 EVEVWML 439
Cdd:PRK14498 404 EVEVELF 410
|
|
| molyb_syn |
TIGR00177 |
molybdenum cofactor synthesis domain; The Drosophila protein cinnamon, the Arabidopsis protein ... |
220-355 |
1.42e-37 |
|
molybdenum cofactor synthesis domain; The Drosophila protein cinnamon, the Arabidopsis protein cnx1, and rat protein gephyrin each have one domain like MoeA and one like MoaB and Mog. These domains are, however, distantly related to each other, as captured by this model. Gephyrin is unusual in that it seems to be a tubulin-binding neuroprotein involved in the clustering of both blycine receptors and GABA receptors, rather than a protein of molybdenum cofactor biosynthesis.
Pssm-ID: 272944 [Multi-domain] Cd Length: 148 Bit Score: 133.98 E-value: 1.42e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 220 LSVLLVTTGDEVVEPGEPLGDGKIYDANGTLLESALRQAGLAVTRAGISADSPEALRALLRSHTSAVDLIVSTGGVSKGA 299
Cdd:TIGR00177 1 PRVAVISVGDELVEGGQPLEPGQIYDSNGPLLAALLQEAGFNVVRLGIVPDDPEEIREILRKAVDEADVVLTTGGTGVGP 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1134500782 300 YEVVRQAMD--GQDVTFGH----------VAMQPGGPQGLGRFDGVPLLAFPGNPVSCLVSFEMFLRP 355
Cdd:TIGR00177 81 RDVTPEALEelGEKEIPGFgefrmlsslpVLSRPGKPATAGVRGGTLIFNLPGNPVSALVTFEVLILP 148
|
|
| MoeA_N |
pfam03453 |
MoeA N-terminal region (domain I and II); This family contains two structural domains. One of ... |
56-185 |
3.64e-32 |
|
MoeA N-terminal region (domain I and II); This family contains two structural domains. One of these contains the conserved DGXA motif. This region is found in proteins involved in biosynthesis of molybdopterin cofactor however the exact molecular function of this region is uncertain.
Pssm-ID: 460923 [Multi-domain] Cd Length: 147 Bit Score: 119.21 E-value: 3.64e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 56 PLLSRERTELLPLVQALGRGLAEDITAPLSLPPFPNSQMDGFAIRSGDVPDGGTSLRVAAPVPAGaspAPLEPGTAVPIM 135
Cdd:pfam03453 1 PLLGTEETVPLEALDALGRVLAEDVVAPRDVPPFDRSAMDGYAVRAADGFGASEVNPIAAGEPPG---PLLPGGEAVRIM 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 1134500782 136 TGAMLPAGADAVVPIEQALpsvfpAAGEEAEVRLPATAAGTFVRAVGSDI 185
Cdd:pfam03453 78 TGAPLPEGADAVVMVEDTE-----EGGGRTVEIRAPVAPGENVRRAGEDI 122
|
|
| MoCF_biosynth |
smart00852 |
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in ... |
224-350 |
6.75e-27 |
|
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor. The domain is presumed to bind molybdopterin. The structure of this domain is known, and it forms an alpha/beta structure. In the known structure of Gephyrin this domain mediates trimerisation.
Pssm-ID: 214856 [Multi-domain] Cd Length: 138 Bit Score: 104.59 E-value: 6.75e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 224 LVTTGDEVVEPGEplgdgkIYDANGTLLESALRQAGLAVTRAGIS--ADSPEALRALLRSHTSAVDLIVSTGGVSKGAYE 301
Cdd:smart00852 2 IISTGDELLSGGQ------IRDSNGPMLAALLRELGIEVVRVVVVggPDDPEAIREALREALAEADVVITTGGTGPGPDD 75
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1134500782 302 VVRQAMD---GQDVTFGHVAMQPGGPQG-----LGRFDGV----PLLAFPGNPVSCLVSFE 350
Cdd:smart00852 76 LTPEALAelgGRELLGHGVAMRPGGPPGplanlSGTAPGVrgkkPVFGLPGNPVAALVMFE 136
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MoeA |
COG0303 |
Molybdopterin Mo-transferase (molybdopterin biosynthesis) [Coenzyme transport and metabolism]; ... |
41-439 |
7.70e-132 |
|
Molybdopterin Mo-transferase (molybdopterin biosynthesis) [Coenzyme transport and metabolism]; Molybdopterin Mo-transferase (molybdopterin biosynthesis) is part of the Pathway/BioSystem: Molybdopterin biosynthesis
Pssm-ID: 440072 [Multi-domain] Cd Length: 401 Bit Score: 385.60 E-value: 7.70e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 41 RSVADHRQAVRELLEPLlsreRTELLPLVQALGRGLAEDITAPLSLPPFPNSQMDGFAIRSGDVPDGG-TSLRVAAPVPA 119
Cdd:COG0303 2 ISVEEALALILAAVRPL----GTETVPLAEALGRVLAEDVVAPRDVPPFDNSAMDGYAVRAADLAGANpVTLRVVGEIAA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 120 G-ASPAPLEPGTAVPIMTGAMLPAGADAVVPIEQAlpsvfpaAGEEAEVRLPAT-AAGTFVRAVGSDIAAGQQALAAGTC 197
Cdd:COG0303 78 GsPPPGPLGPGEAVRIMTGAPLPEGADAVVMQEDT-------EREGDRVTIRKPvAPGENIRRAGEDIAAGDVLLPAGTR 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 198 LGPAQLGLLAALGLPEVLVHKQLSVLLVTTGDEVVEPGEPLGDGKIYDANGTLLESALRQAGLAVTRAGISADSPEALRA 277
Cdd:COG0303 151 LTPADLGLLASLGIAEVPVYRRPRVAILSTGDELVEPGEPLGPGQIYDSNSYMLAALLREAGAEVVDLGIVPDDPEALRA 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 278 LLRSHTSAVDLIVSTGGVSKGAYEVVRQAMD--GQDVTFGHVAMQPGGPQGLGRFDGVPLLAFPGNPVSCLVSFEMFLRP 355
Cdd:COG0303 231 ALREALAEADLVITSGGVSVGDYDLVKEALEelGAEVLFHKVAMKPGKPLAFGRLGGKPVFGLPGNPVSALVTFELFVRP 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 356 VLGELFGAPAP-RPAVRARLAQPLSSPAGKHQVRRGSL---QGDGTVRLQGGESSHLVQALAHSNALVHVPAGTAVLNEG 431
Cdd:COG0303 311 ALRKLAGLPPPpPPRVRARLAEDLPKKPGRTEFLRVRLerdDGELVVEPLGGQGSGLLSSLAEADGLIVLPEGVEGVEAG 390
|
....*...
gi 1134500782 432 AEVEVWML 439
Cdd:COG0303 391 EEVEVLLL 398
|
|
| MoeA |
cd00887 |
MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor ... |
48-439 |
6.73e-128 |
|
MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MoeA, together with MoaB, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes.
Pssm-ID: 238452 [Multi-domain] Cd Length: 394 Bit Score: 375.29 E-value: 6.73e-128
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 48 QAVRELLEPLLSRERTELLPLVQALGRGLAEDITAPLSLPPFPNSQMDGFAIRSGDVPDGGTSLRVAAPVPAGASPA-PL 126
Cdd:cd00887 2 EAARELLLALAPPLGTETVPLLEALGRVLAEDVVAPIDLPPFDNSAMDGYAVRAADTAGASVTLRVVGEIPAGEPPDgPL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 127 EPGTAVPIMTGAMLPAGADAVVPIEQAlpsvfpaAGEEAEVRLPATA-AGTFVRAVGSDIAAGQQALAAGTCLGPAQLGL 205
Cdd:cd00887 82 GPGEAVRIMTGAPLPEGADAVVMVEDT-------EEEGGRVTITKPVkPGQNIRRAGEDIKAGDVLLPAGTRLTPADIGL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 206 LAALGLPEVLVHKQLSVLLVTTGDEVVEPGEPLGDGKIYDANGTLLESALRQAGLAVTRAGISADSPEALRALLRSHTSA 285
Cdd:cd00887 155 LASLGIAEVPVYRRPRVAIISTGDELVEPGEPLAPGQIYDSNSYMLAALLRELGAEVVDLGIVPDDPEALREALEEALEE 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 286 VDLIVSTGGVSKGAYEVVRQAMD--GQDVTFGHVAMQPGGPQGLGRFDGVPLLAFPGNPVSCLVSFEMFLRPVLGELFGA 363
Cdd:cd00887 235 ADVVITSGGVSVGDYDFVKEVLEelGGEVLFHGVAMKPGKPLAFGRLGGKPVFGLPGNPVSALVTFELFVRPALRKLQGA 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 364 PAPRPA-VRARLAQPLSSPAGKHQVRRGSLQ---GDGTVRLQGGESSHLVQALAHSNALVHVPAGTAVLNEGAEVEVWML 439
Cdd:cd00887 315 PEPEPPrVKARLAEDLKSKPGRREFLRVRLErdeGGLVVAPPGGQGSGLLSSLARADGLIVIPEGVEGLEAGEEVEVLLL 394
|
|
| PRK14498 |
PRK14498 |
putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing ... |
42-439 |
4.24e-81 |
|
putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional
Pssm-ID: 237732 [Multi-domain] Cd Length: 633 Bit Score: 262.46 E-value: 4.24e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 42 SVADHRQAVRELLEPLlsRERTELLPLVQALGRGLAEDITAPLSLPPFPNSQMDGFAIRSGDVPDGGTS----LRVAAPV 117
Cdd:PRK14498 11 SLEEAREILESLLSEL--PLGTEEVPLEEALGRVLAEDVYAPIDVPPFDRSAMDGYAVRAADTFGASEAnpvrLKLGGEV 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 118 PAGASPA-PLEPGTAVPIMTGAMLPAGADAVVPIEQalpsVFPAAGEEAEVRLPAtAAGTFVRAVGSDIAAGQQALAAGT 196
Cdd:PRK14498 89 HAGEAPDvEVEPGEAVEIATGAPIPRGADAVVMVED----TEEVDDDTVEIYRPV-APGENVRPAGEDIVAGELILPKGT 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 197 CLGPAQLGLLAALGLPEVLVHKQLSVLLVTTGDEVVEPGEPLGDGKIYDANGTLLESALRQAGLAVTRAGISADSPEALR 276
Cdd:PRK14498 164 RLTPRDIGALAAGGVAEVPVYKKPRVGIISTGDELVEPGEPLKPGKIYDVNSYTLAAAVEEAGGEPVRYGIVPDDEEELE 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 277 ALLRSHTSAVDLIVSTGGVSKGAYEVVRQAMDGQDVTFGH-VAMQPGGPQGLGRFDGVPLLAFPGNPVSCLVSFEMFLRP 355
Cdd:PRK14498 244 AALRKALKECDLVLLSGGTSAGAGDVTYRVIEELGEVLVHgVAIKPGKPTILGVIGGKPVVGLPGYPVSALTIFEEFVAP 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 356 VLGELFGAPAPRPA-VRARLAQPLSSPAGKHQVRRGSL--QGDGTVRLQGGESSHLVQALAHSNALVHVPAGTAVLNEGA 432
Cdd:PRK14498 324 LLRKLAGLPPPERAtVKARLARRVRSELGREEFVPVSLgrVGDGYVAYPLSRGSGAITSLVRADGFIEIPANTEGLEAGE 403
|
....*..
gi 1134500782 433 EVEVWML 439
Cdd:PRK14498 404 EVEVELF 410
|
|
| PRK14491 |
PRK14491 |
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA; ... |
42-434 |
1.27e-65 |
|
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA; Provisional
Pssm-ID: 237729 [Multi-domain] Cd Length: 597 Bit Score: 220.64 E-value: 1.27e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 42 SVADHRQAVRELLEPLlsrERTELLPLVQALGRGLAEDITAPLSLPPFPNSQMDGFAIRSGDVPDGgtSLRVAAPVPAGA 121
Cdd:PRK14491 200 SVSQGLDKILSLVTPV---TETEDVALDELDGRVLAQDVISPVNVPQHTNSAMDGYAFRSDDLEPE--SYTLVGEVLAGH 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 122 S-PAPLEPGTAVPIMTGAMLPAGADAVVPIEQAlpsvfpaAGEEAEVRLPAT-AAGTFVRAVGSDIAAGQQALAAGTCLG 199
Cdd:PRK14491 275 QyDGTLQAGEAVRIMTGAPVPAGADTVVMRELA-------TQDGDKVSFDGGiKAGQNVRLAGEDLAQGQVALAAGTRLS 347
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 200 PAQLGLLAALGLPEVLVHKQLSVLLVTTGDEVVEPGEPLGDGKIYDANGTLLESALRQAGLAVTRAGISADSPEALRALL 279
Cdd:PRK14491 348 APEQGLLASLGFAEVPVFRRPKVAVFSTGDEVQAPGETLKPNCIYDSNRFTIKAMAKKLGCEVIDLGIIEDSEAALEATL 427
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 280 RSHTSAVDLIVSTGGVSKGAYEVVRQAMD--GQdVTFGHVAMQPGGPQGLGRFDGVPLLAFPGNPVSCLVSFEMFLRPVL 357
Cdd:PRK14491 428 EQAAAQADVVISSGGVSVGDADYIKTALAklGQ-IDFWRINMRPGRPLAFGQIGDSPFFGLPGNPVAVMVSFLQFVEPAL 506
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 358 GELFGAPAPRP-AVRARLAQPLSSPAGKHQVRRG--SLQGDG--TVRLQGGESSHLVQALAHSNALVHVPAGTAVLNEGA 432
Cdd:PRK14491 507 RKLAGEQNWQPlLFPAIADETLRSRQGRTEFSRGiyHLGADGrlHVRTTGKQGSGILSSMSEANCLIEIGPAAETVNAGE 586
|
..
gi 1134500782 433 EV 434
Cdd:PRK14491 587 TV 588
|
|
| PRK10680 |
PRK10680 |
molybdopterin biosynthesis protein MoeA; Provisional |
48-435 |
3.08e-65 |
|
molybdopterin biosynthesis protein MoeA; Provisional
Pssm-ID: 182643 [Multi-domain] Cd Length: 411 Bit Score: 214.96 E-value: 3.08e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 48 QAVRELLEPLLSRERTELLPLVQALGRGLAEDITAPLSLPPFPNSQMDGFAIRSGDVpDGGTSLRVAAPVPAGAS----- 122
Cdd:PRK10680 12 TALTEMLSRVTPLTATETLPLVQCFGRITASDIVSPLDVPGFDNSAMDGYAVRLADL-ASGQPLPVAGKAFAGQPfhgew 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 123 PAplepGTAVPIMTGAMLPAGADAVVPIEQALPSvfpaageEAEVRLPA-TAAGTFVRAVGSDIAAGQQALAAGTCLGPA 201
Cdd:PRK10680 91 PA----GTCIRIMTGAPVPEGCEAVVMQEQTEQT-------DDGVRFTAeVRSGQNIRRRGEDISQGAVVFPAGTRLTTA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 202 QLGLLAALGLPEVLVHKQLSVLLVTTGDEVVEPGEPLGDGKIYDANGTLLESALRQAGLAVTRAGISADSPEALRALLRS 281
Cdd:PRK10680 160 ELPVLASLGIAEVPVVRKVRVALFSTGDELQLPGQPLGDGQIYDTNRLAVHLMLEQLGCEVINLGIIRDDPHALRAAFIE 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 282 HTSAVDLIVSTGGVSKGAYEVVRQAMDG-QDVTFGHVAMQPGGPQGLGRFDGVPLLAFPGNPVSCLVSFEMFLRPVLGEL 360
Cdd:PRK10680 240 ADSQADVVISSGGVSVGEADYTKTILEElGEIAFWKLAIKPGKPFAFGKLSNSWFCGLPGNPVSAALTFYQLVQPLLAKL 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 361 FG--APAPRPAVRARLAQPLSSPAGKHQVRRGSLQ----GDGTVRLQGGESSHLVQALAHSNALV-------HVPAGtav 427
Cdd:PRK10680 320 SGntASGLPPRQRVRTASRLKKTPGRLDFQRGILQrnadGELEVTTTGHQGSHIFSSFSLGNCFIvlerergNVEVG--- 396
|
....*...
gi 1134500782 428 lnEGAEVE 435
Cdd:PRK10680 397 --EWVEVE 402
|
|
| PLN02699 |
PLN02699 |
Bifunctional molybdopterin adenylyltransferase/molybdopterin molybdenumtransferase |
66-434 |
2.62e-47 |
|
Bifunctional molybdopterin adenylyltransferase/molybdopterin molybdenumtransferase
Pssm-ID: 215376 [Multi-domain] Cd Length: 659 Bit Score: 172.30 E-value: 2.62e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 66 LPLVQALGRGLAEDITAPLSLPPFPNSQMDGFAIRSGDVPdGGTSLRVAAPVPAGASPAPLEPGTAVPIMTGAMLPAGAD 145
Cdd:PLN02699 29 VPLHEALGKVLAEDIRAPDPLPPYPASVKDGYAVVASDGP-GEYPVITESRAGNDGLGVTLTPGTVAYVTTGGPIPDGAD 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 146 AVVPIEQALPSVFPAAGEEAEVRLPATAAGTFVRAVGSDIAAGQQALAAGTCLGPAQLGLLAALGLPEVLVHKQLSVLLV 225
Cdd:PLN02699 108 AVVQVEDTEVVEDPLDGSKRVRILSQASKGQDIRPVGCDIEKDAKVLKAGERLGASEIGLLATVGVTMVKVYPRPTVAIL 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 226 TTGDEVVEPGEP-LGDGKIYDANGTLLESALRQAGLAVTRAGISADSPEALRALLRSHTSA-VDLIVSTGGVSKGAYEVV 303
Cdd:PLN02699 188 STGDELVEPTTGtLGRGQIRDSNRAMLLAAAIQQQCKVVDLGIARDDEEELERILDEAISSgVDILLTSGGVSMGDRDFV 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 304 RQAMDGQ-DVTFGHVAMQPGGPQGLGRFDGVP-------LLAF--PGNPVSCLVSFEMFLRPVLGELFGAPAPRPA-VRA 372
Cdd:PLN02699 268 KPLLEKRgTVYFSKVLMKPGKPLTFAEIDAKSapsnskkMLAFglPGNPVSCLVCFNLFVVPAIRYLAGWSNPHLLrVQA 347
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1134500782 373 RLAQPLSSPAGKHQVRRGSLQ---GDGTVR------LQGGESSHLVQALAHSNALVHVPAGTAVLNEGAEV 434
Cdd:PLN02699 348 RLREPIKLDPVRPEFHRAIIRwklNDGSGNpgfvaeSTGHQMSSRLLSMKSANALLELPATGNVLSAGTSV 418
|
|
| PRK14497 |
PRK14497 |
putative molybdopterin biosynthesis protein MoeA/unknown domain fusion protein; Provisional |
48-438 |
9.18e-46 |
|
putative molybdopterin biosynthesis protein MoeA/unknown domain fusion protein; Provisional
Pssm-ID: 172968 [Multi-domain] Cd Length: 546 Bit Score: 166.14 E-value: 9.18e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 48 QAVRELLEPLLSRERTELLPLVQALGRGLAEDITAPLSLPPFPNSQMDGFAIRSGDVPDggtSLRVAAPVPAGA-SPAPL 126
Cdd:PRK14497 15 EAIKVFLSSLNFKPKIVKVEVKDSFGYVSAEDLMSPIDYPPFSRSTVDGYALKSSCTPG---EFKVIDKIGIGEfKEIHI 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 127 EPGTAVPIMTGAMLPAGADAVVPIEQALPSVFPAAGEEAEVRLpataaGTFVRAVGSDIAAGQQALAAGTCLGPAQLGLL 206
Cdd:PRK14497 92 KECEAVEVDTGSMIPMGADAVIKVENTKVINGNFIKIDKKINF-----GQNIGWIGSDIPKGSIILRKGEVISHEKIGLL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 207 AALGLPEVLVHKQLSVLLVTTGDEVVEPGEPLGDGKIYDANGTLLESALRQAGLAVTRAGISADSPEALRALLRSHTSAV 286
Cdd:PRK14497 167 ASLGISSVKVYEKPKIYLIATGDELVEPGNSLSPGKIYESNLHYLYSKLKSEGYKIVGLSLLSDDKESIKNEIKRAISVA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 287 DLIVSTGGVSKGAYEVVRQAMD--GQDVTFGhVAMQPGGPQGLGRFDGVPLLAFPGNPVSCLVSFEMFLRPVLGELFGA- 363
Cdd:PRK14497 247 DVLILTGGTSAGEKDFVHQAIRelGNIIVHG-LKIKPGKPTILGIVDGKPVIGLPGNIVSTMVVLNMVILEYLKSLYPSr 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 364 --PAPRPAVRARLAQPLSspAGKHQVRRGS---LQGDGT-VRLQGGESSHLVQALAHSNALVHVPAGTAVlNEGAEVEVW 437
Cdd:PRK14497 326 keILGLGKIKARLALRVK--ADEHRNTLIPvylFKSDNSyYALPVPFDSYMVGTFSLTDGYIMLGPNEEI-EEGKEVEVD 402
|
.
gi 1134500782 438 M 438
Cdd:PRK14497 403 L 403
|
|
| PRK14690 |
PRK14690 |
molybdopterin biosynthesis protein MoeA; Provisional |
50-434 |
9.47e-39 |
|
molybdopterin biosynthesis protein MoeA; Provisional
Pssm-ID: 237789 [Multi-domain] Cd Length: 419 Bit Score: 144.67 E-value: 9.47e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 50 VRELLEPLLSrerTELLPLVQALGRGLAEDITAPLSLPPFPNSQMDGFAIrSGDVPDGGTSL-----RVAAPVPAGASpa 124
Cdd:PRK14690 32 LRARLGPVTD---IKELDLSDALGHVLAHDAVALRSNPPQANSAVDGYGF-AGAAPEGAQVLpliegRAAAGVPFSGR-- 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 125 pLEPGTAVPIMTGAMLPAGADAVVPIEQAlpsvfPAAGEEAEVRLPaTAAGTFVRAVGSDIAAGQQALAAGTCLGPAQLG 204
Cdd:PRK14690 106 -VPEGMALRILTGAALPEGVDTVVLEEDV-----AGDGHRIAFHGP-LKMGANTRKAGEDVIAGDVALPAGRRLTPADLA 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 205 LLAALGLPEVLVHKQLSVLLVTTGDEVVEPGEPLGDGKIYDANGTLLESALRQAGLAVTRAGISADSPEALRALLRSHTS 284
Cdd:PRK14690 179 LLSAVGLTRVSVRRPLRVAVLSTGDELVEPGALAEVGQIYDANRPMLLALARRWGHAPVDLGRVGDDRAALAARLDRAAA 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 285 AVDLIVSTGGVSKGAYEVVRQAMDGQDVTFG-HVAMQPGGPQGLGRFDGVPLLAFPGNPVSCLVSFEMFLRPVLGELFGA 363
Cdd:PRK14690 259 EADVILTSGGASAGDEDHVSALLREAGAMQSwRIALKPGRPLALGLWQGVPVFGLPGNPVAALVCTLVFARPAMSLLAGE 338
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1134500782 364 PAPRPavrarlaQPLSSPAG----KHQVRRGSLQG---DGTVRLQGGESSHLVQALAHSNALVHVPAGTAVLNEGAEV 434
Cdd:PRK14690 339 GWSEP-------QGFTVPAAfekrKKPGRREYLRArlrQGHAEVFRSEGSGRISGLSWAEGLVELGDGARRIAPGDPV 409
|
|
| molyb_syn |
TIGR00177 |
molybdenum cofactor synthesis domain; The Drosophila protein cinnamon, the Arabidopsis protein ... |
220-355 |
1.42e-37 |
|
molybdenum cofactor synthesis domain; The Drosophila protein cinnamon, the Arabidopsis protein cnx1, and rat protein gephyrin each have one domain like MoeA and one like MoaB and Mog. These domains are, however, distantly related to each other, as captured by this model. Gephyrin is unusual in that it seems to be a tubulin-binding neuroprotein involved in the clustering of both blycine receptors and GABA receptors, rather than a protein of molybdenum cofactor biosynthesis.
Pssm-ID: 272944 [Multi-domain] Cd Length: 148 Bit Score: 133.98 E-value: 1.42e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 220 LSVLLVTTGDEVVEPGEPLGDGKIYDANGTLLESALRQAGLAVTRAGISADSPEALRALLRSHTSAVDLIVSTGGVSKGA 299
Cdd:TIGR00177 1 PRVAVISVGDELVEGGQPLEPGQIYDSNGPLLAALLQEAGFNVVRLGIVPDDPEEIREILRKAVDEADVVLTTGGTGVGP 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1134500782 300 YEVVRQAMD--GQDVTFGH----------VAMQPGGPQGLGRFDGVPLLAFPGNPVSCLVSFEMFLRP 355
Cdd:TIGR00177 81 RDVTPEALEelGEKEIPGFgefrmlsslpVLSRPGKPATAGVRGGTLIFNLPGNPVSALVTFEVLILP 148
|
|
| MoeA_N |
pfam03453 |
MoeA N-terminal region (domain I and II); This family contains two structural domains. One of ... |
56-185 |
3.64e-32 |
|
MoeA N-terminal region (domain I and II); This family contains two structural domains. One of these contains the conserved DGXA motif. This region is found in proteins involved in biosynthesis of molybdopterin cofactor however the exact molecular function of this region is uncertain.
Pssm-ID: 460923 [Multi-domain] Cd Length: 147 Bit Score: 119.21 E-value: 3.64e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 56 PLLSRERTELLPLVQALGRGLAEDITAPLSLPPFPNSQMDGFAIRSGDVPDGGTSLRVAAPVPAGaspAPLEPGTAVPIM 135
Cdd:pfam03453 1 PLLGTEETVPLEALDALGRVLAEDVVAPRDVPPFDRSAMDGYAVRAADGFGASEVNPIAAGEPPG---PLLPGGEAVRIM 77
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 1134500782 136 TGAMLPAGADAVVPIEQALpsvfpAAGEEAEVRLPATAAGTFVRAVGSDI 185
Cdd:pfam03453 78 TGAPLPEGADAVVMVEDTE-----EGGGRTVEIRAPVAPGENVRRAGEDI 122
|
|
| MoCF_biosynth |
pfam00994 |
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in ... |
225-357 |
1.11e-27 |
|
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor. The domain is presumed to bind molybdopterin. The structure of this domain is known, and it forms an alpha/beta structure. In the known structure of Gephyrin this domain mediates trimerization.
Pssm-ID: 425979 [Multi-domain] Cd Length: 143 Bit Score: 106.95 E-value: 1.11e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 225 VTTGDEVVEpgeplgdGKIYDANGTLLESALRQAGLAVTRAGISADSPEALRALLRSHTSAVDLIVSTGGVSKGAYEVVR 304
Cdd:pfam00994 3 ITTGDELLP-------GQIRDTNGPLLAALLREAGAEVIRYGIVPDDPEAIKEALRAAAEEADVVITTGGTGPGPDDVTP 75
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1134500782 305 QAM--------DGQDVTFGHVAMQPGGPQGLGRF-----DGVPLLAFPGNPVSCLVSFEMFLRPVL 357
Cdd:pfam00994 76 EALaelggrelPGFEELFRGVSLKPGKPVGTAPGailsrAGKTVFGLPGSPVAAKVMFELLLLPLL 141
|
|
| MoCF_biosynth |
smart00852 |
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in ... |
224-350 |
6.75e-27 |
|
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor. The domain is presumed to bind molybdopterin. The structure of this domain is known, and it forms an alpha/beta structure. In the known structure of Gephyrin this domain mediates trimerisation.
Pssm-ID: 214856 [Multi-domain] Cd Length: 138 Bit Score: 104.59 E-value: 6.75e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 224 LVTTGDEVVEPGEplgdgkIYDANGTLLESALRQAGLAVTRAGIS--ADSPEALRALLRSHTSAVDLIVSTGGVSKGAYE 301
Cdd:smart00852 2 IISTGDELLSGGQ------IRDSNGPMLAALLRELGIEVVRVVVVggPDDPEAIREALREALAEADVVITTGGTGPGPDD 75
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1134500782 302 VVRQAMD---GQDVTFGHVAMQPGGPQG-----LGRFDGV----PLLAFPGNPVSCLVSFE 350
Cdd:smart00852 76 LTPEALAelgGRELLGHGVAMRPGGPPGplanlSGTAPGVrgkkPVFGLPGNPVAALVMFE 136
|
|
| MoCF_BD |
cd00758 |
MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of ... |
222-357 |
1.31e-22 |
|
MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin.
Pssm-ID: 238387 [Multi-domain] Cd Length: 133 Bit Score: 92.79 E-value: 1.31e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 222 VLLVTTGDEVVEpgeplgdGKIYDANGTLLESALRQAGLAVTRAGISADSPEALRALLRSHTSAVDLIVSTGGVSKGAYE 301
Cdd:cd00758 2 VAIVTVSDELSQ-------GQIEDTNGPALEALLEDLGCEVIYAGVVPDDADSIRAALIEASREADLVLTTGGTGVGRRD 74
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1134500782 302 VVRQAMD---GQDVTFGHVAMQPGGPQGLGRFDGVPLLAFPGNPVSCLVSFEMFLRPVL 357
Cdd:cd00758 75 VTPEALAelgEREAHGKGVALAPGSRTAFGIIGKVLIINLPGSPKSALTTFEALVLPAL 133
|
|
| MoeA_C |
pfam03454 |
MoeA C-terminal region (domain IV); This domain is found in proteins involved in biosynthesis ... |
371-439 |
3.55e-08 |
|
MoeA C-terminal region (domain IV); This domain is found in proteins involved in biosynthesis of molybdopterin cofactor however the exact molecular function of this domain is uncertain. The structure of this domain is known and forms an incomplete beta barrel.
Pssm-ID: 460924 [Multi-domain] Cd Length: 72 Bit Score: 50.30 E-value: 3.55e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1134500782 371 RARLAQPLSSPAGKHQVRRGSL---QGDGTVRLQGGESSHLVQALAHSNALVHVPAGTAVLNEGAEVEVWML 439
Cdd:pfam03454 1 KARLARDLKSDPGRREFVRVRLheeDGRYYAEPIGKQGSGMLSSLAEANGLIVVPEGTEGLEAGEEVEVILL 72
|
|
| MoeA_like |
cd03522 |
MoeA_like. This domain is similar to a domain found in a variety of proteins involved in ... |
213-340 |
1.05e-05 |
|
MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is unknown.
Pssm-ID: 239599 Cd Length: 312 Bit Score: 47.16 E-value: 1.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134500782 213 EVLVHKQLSVLLVTTGDEVvepgeplGDGKIYDANGTLLESALRQAGLAVTRAGISADSPEALRALLRSHTSAV-DLIVS 291
Cdd:cd03522 153 RVAPFRPLRVGLIVTGSEV-------YGGRIEDKFGPVLRARLAALGVELVEQVIVPHDEAAIAAAIAEALEAGaELLIL 225
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 1134500782 292 TGGVSKGAYEVVRQAM---DGQDVTFGhVAMQPGGPQGLGRFDGVPLLAFPG 340
Cdd:cd03522 226 TGGASVDPDDVTPAAIraaGGEVIRYG-MPVDPGNLLLLGYLGGVPVIGLPG 276
|
|
| cinA |
cd00885 |
Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon ... |
224-294 |
6.73e-05 |
|
Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, where the domain is presumed to bind molybdopterin.
Pssm-ID: 238450 [Multi-domain] Cd Length: 170 Bit Score: 43.24 E-value: 6.73e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1134500782 224 LVTTGDEVVepgeplgDGKIYDANGTLLESALRQAGLAVTRAGISADSPEALRALLRSHTSAVDLIVSTGG 294
Cdd:cd00885 4 IIAIGDELL-------SGQIVDTNAAFLAKELAELGIEVYRVTVVGDDEDRIAEALRRASERADLVITTGG 67
|
|
| MoaB |
COG0521 |
Molybdopterin biosynthesis enzyme MoaB/MogA [Coenzyme transport and metabolism]; Molybdopterin ... |
245-294 |
3.22e-03 |
|
Molybdopterin biosynthesis enzyme MoaB/MogA [Coenzyme transport and metabolism]; Molybdopterin biosynthesis enzyme MoaB/MogA is part of the Pathway/BioSystem: Molybdopterin biosynthesis
Pssm-ID: 440287 [Multi-domain] Cd Length: 169 Bit Score: 38.17 E-value: 3.22e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 1134500782 245 DANGTLLESALRQAGLAVTRAGISADSPEALRALLRS--HTSAVDLIVSTGG 294
Cdd:COG0521 28 DTSGPALVELLEEAGHEVVARRIVPDDKDAIRAALREliDDEGVDLVLTTGG 79
|
|
| MogA_MoaB |
cd00886 |
MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum ... |
245-294 |
7.74e-03 |
|
MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MogA, together with MoeA, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes. In contrast, MoaB shows high similarity to MogA, but little is known about its physiological role. All well studied members of this family form highly stable trimers.
Pssm-ID: 238451 [Multi-domain] Cd Length: 152 Bit Score: 36.69 E-value: 7.74e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 1134500782 245 DANGTLLESALRQAGLAVTRAGISADSPEALRALLR--SHTSAVDLIVSTGG 294
Cdd:cd00886 19 DRSGPALVELLEEAGHEVVAYEIVPDDKDEIREALIewADEDGVDLILTTGG 70
|
|
| |
