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Conserved domains on  [gi|1110846837|gb|APG61158|]
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SusC/RagA family protein [Gramella salexigens]

Protein Classification

SusC/RagA family TonB-linked outer membrane protein( domain architecture ID 1000763)

SusC/RagA family TonB-linked outer membrane protein

Gene Ontology:  GO:0022857|GO:0009279

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
OMP_RagA_SusC super family cl37378
TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade ...
 25-1071 2.80e-178

TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate]


The actual alignment was detected with superfamily member TIGR04056:

Pssm-ID: 274948 [Multi-domain]  Cd Length: 981  Bit Score: 546.80  E-value: 2.80e-178
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837   25 QTVTGTVTDEDGIPLPGVNIVVKGTSTGVQTDFDGNYSIEAEVGDVLVYSFVGLKTAEYPVYNNDKLDVVLEADSAQLDE 104
Cdd:TIGR04056    1 ITVTGVVVDETGEPLIGASVVVKGTTNGTITDIDGNFSLKVPPGAVLVFSYIGYKTQEVKVKGQKNLNITLKEDTQELDE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  105 VVVTALGIsRDKKSLGYATQEVDGTEVNTAKEGNFVNSLSGKISGLDIKKSS-TLGGSSNVVIRGYSSITGNNQALFVID 183
Cdd:TIGR04056   81 VVVVGYGT-QKKKSLTGAVSTVKAKELKKVPVSNLSNALQGKVAGVIITQSSgEPGGDAEIWIRGISSFGGNNSPLYVID 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  184 GVPvnnstfntssqerGSNGFdygnaaSDINPDDIKSVNVLKGAAATALYGSRAANGAVIITTKKGATSK-----GIGVT 258
Cdd:TIGR04056  160 GVP-------------RDNGL------SDLNPEDIESISVLKDASATAIYGSRGANGVILITTKRGKEGKpkisyNAEFG 220

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  259 INSSIMVGNY-DPDTFAEYQTEYGqgygpyygngpgngflsgdINQDGTGDLVVPTTEDASQGSRFDPNLmvYGWKSFYP 337
Cdd:TIGR04056  221 FSTPTRLPEMlNAYEYAELYNEAL-------------------LNRGSSPPDIYTDEEIEAYRNGLDPDL--YPNTDWQD 279

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  338 ELdsyqqaepwtaakngpssIFQTAYTDTENISVTSGGENGSARMSYTRFNQTGIMPNSEITRNSLDFSGTLKLTDKLTT 417
Cdd:TIGR04056  280 EI------------------FKRTAFNQRHNLSVSGGTEKARYYVSLGYYNEEGILKNSDYKRYNFRANIDAKLTKTLKL 341

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  418 SAKAIYTKNSGLGRYGTGYDADNLMTNFREWWATNVDlqeqrdAYFQTGRNITWNpfgpDNTKPIYwdNPYFTRYENYNT 497
Cdd:TIGR04056  342 SLNVSGSLSKYNNPGGSTSNIWGALMLFPRGTPYSTP------PVYSDGYYPAYN----SGNTSLQ--NPYALLNRGYNE 409

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  498 DERNRLFGYATIQYDINDWLDAKGRVSVDTYSELREERNN-------IGSVDLPEYNRFNINFTELNYDLFLNFDHDFGE 570
Cdd:TIGR04056  410 NERNRLNGNASLEQKITKGLKLKGTFSYDYSNYKNKKYYKnpyyynaTGGANNGYYSESNSRSRNYYLEATLNYNRTFGK 489

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  571 FGATGTLGANYRQTKLSSIYAQTNGgltLPGLYTLSNSAAPINFPEENesdvRVLGLFATASFDYKDTFFVEGSLRRDTF 650
Cdd:TIGR04056  490 HNVSALLGYSQQENKSSSYGGLLDD---LPSLDAGTSDASVSGSDSEY----RLQSLFGRATYSYKDRYLLEFNFRYDGS 562

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  651 STLPDGDNAFNYPAISTSIIFS------KLidSDAITYGKLRAGYGEVGNGAE----PYQLSNTFNAVASFNGTPLYS-- 718
Cdd:TIGR04056  563 SRFAKGNRWGFFPSVSLGWRISeekfmkKL--KKWLSFLKLRASYGIVGNDNIgdryPYLSLYNLGDGGYNFGTNNGTsv 640

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  719 ---NPSVAKNANLTEERTNELEIGLEMSFLEKRLGFDASIYKKETENQIIPVTVSSATGFNSSVVNSGVVEQEGLELSMF 795
Cdd:TIGR04056  641 tgiTESRYGNPNLKWEKTKKWNLGLDLGFFNNRLSLTVDYYYKKTKDILQSRSLPSVTGYSSPYANIGKVKNKGVELSLN 720

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  796 GSPIRTKDFEWRINTNFATYESTVTKlYGDSQNLLVNSFFGVTLNAALDQPYGVI-----------KGTDYVYENGQRVV 864
Cdd:TIGR04056  721 YRNKIGKDFSWSVRGNFTYNKNKILE-LDEGAYLPVKYPYISKEGGPIGQIYGYIadglfkdddspKQTFGNVRPGDIKY 799

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  865 RE-DGLYAKTSSRQEVIGD-INPDWKAGIQNVLSYKNWNFSFLVDVQEGGSVFSGDLYFGMATGLYPITAGLNDLGNPKR 942
Cdd:TIGR04056  800 KDvNGDGKIDDDDRVPIGYsNTPDLTYGFGNSFSYKGFDLSALFQGSGGGDVFNDGRGFYPFNGGDWGNVLKIVADNRWT 879

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  943 DPVTDGPdsggviLPGVQADGTTNTVRADASTYanpygrygnapdaqFVYDASYIKLREMVVSYNLPSDILDTLPFTGVK 1022
Cdd:TIGR04056  880 PENPNAD------YPRLSYGDSNNSNNYQASTR--------------WLEDGSYLRLKNLTLGYTLPKKWLKKIGISNLR 939

                         1050      1060      1070      1080
                   ....*....|....*....|....*....|....*....|....*....
gi 1110846837 1023 FSAVGRNLWIIDKDLPYaDPEsgfsagnVQGFQIGAYPSTKEYGLNVQL 1071
Cdd:TIGR04056  940 VYFSGQNLFTFSKYKGW-DPE-------LQGNDGGAYPLQRTFSFGVNL 980
 
Name Accession Description Interval E-value
OMP_RagA_SusC TIGR04056
TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade ...
 25-1071 2.80e-178

TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 274948 [Multi-domain]  Cd Length: 981  Bit Score: 546.80  E-value: 2.80e-178
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837   25 QTVTGTVTDEDGIPLPGVNIVVKGTSTGVQTDFDGNYSIEAEVGDVLVYSFVGLKTAEYPVYNNDKLDVVLEADSAQLDE 104
Cdd:TIGR04056    1 ITVTGVVVDETGEPLIGASVVVKGTTNGTITDIDGNFSLKVPPGAVLVFSYIGYKTQEVKVKGQKNLNITLKEDTQELDE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  105 VVVTALGIsRDKKSLGYATQEVDGTEVNTAKEGNFVNSLSGKISGLDIKKSS-TLGGSSNVVIRGYSSITGNNQALFVID 183
Cdd:TIGR04056   81 VVVVGYGT-QKKKSLTGAVSTVKAKELKKVPVSNLSNALQGKVAGVIITQSSgEPGGDAEIWIRGISSFGGNNSPLYVID 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  184 GVPvnnstfntssqerGSNGFdygnaaSDINPDDIKSVNVLKGAAATALYGSRAANGAVIITTKKGATSK-----GIGVT 258
Cdd:TIGR04056  160 GVP-------------RDNGL------SDLNPEDIESISVLKDASATAIYGSRGANGVILITTKRGKEGKpkisyNAEFG 220

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  259 INSSIMVGNY-DPDTFAEYQTEYGqgygpyygngpgngflsgdINQDGTGDLVVPTTEDASQGSRFDPNLmvYGWKSFYP 337
Cdd:TIGR04056  221 FSTPTRLPEMlNAYEYAELYNEAL-------------------LNRGSSPPDIYTDEEIEAYRNGLDPDL--YPNTDWQD 279

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  338 ELdsyqqaepwtaakngpssIFQTAYTDTENISVTSGGENGSARMSYTRFNQTGIMPNSEITRNSLDFSGTLKLTDKLTT 417
Cdd:TIGR04056  280 EI------------------FKRTAFNQRHNLSVSGGTEKARYYVSLGYYNEEGILKNSDYKRYNFRANIDAKLTKTLKL 341

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  418 SAKAIYTKNSGLGRYGTGYDADNLMTNFREWWATNVDlqeqrdAYFQTGRNITWNpfgpDNTKPIYwdNPYFTRYENYNT 497
Cdd:TIGR04056  342 SLNVSGSLSKYNNPGGSTSNIWGALMLFPRGTPYSTP------PVYSDGYYPAYN----SGNTSLQ--NPYALLNRGYNE 409

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  498 DERNRLFGYATIQYDINDWLDAKGRVSVDTYSELREERNN-------IGSVDLPEYNRFNINFTELNYDLFLNFDHDFGE 570
Cdd:TIGR04056  410 NERNRLNGNASLEQKITKGLKLKGTFSYDYSNYKNKKYYKnpyyynaTGGANNGYYSESNSRSRNYYLEATLNYNRTFGK 489

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  571 FGATGTLGANYRQTKLSSIYAQTNGgltLPGLYTLSNSAAPINFPEENesdvRVLGLFATASFDYKDTFFVEGSLRRDTF 650
Cdd:TIGR04056  490 HNVSALLGYSQQENKSSSYGGLLDD---LPSLDAGTSDASVSGSDSEY----RLQSLFGRATYSYKDRYLLEFNFRYDGS 562

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  651 STLPDGDNAFNYPAISTSIIFS------KLidSDAITYGKLRAGYGEVGNGAE----PYQLSNTFNAVASFNGTPLYS-- 718
Cdd:TIGR04056  563 SRFAKGNRWGFFPSVSLGWRISeekfmkKL--KKWLSFLKLRASYGIVGNDNIgdryPYLSLYNLGDGGYNFGTNNGTsv 640

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  719 ---NPSVAKNANLTEERTNELEIGLEMSFLEKRLGFDASIYKKETENQIIPVTVSSATGFNSSVVNSGVVEQEGLELSMF 795
Cdd:TIGR04056  641 tgiTESRYGNPNLKWEKTKKWNLGLDLGFFNNRLSLTVDYYYKKTKDILQSRSLPSVTGYSSPYANIGKVKNKGVELSLN 720

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  796 GSPIRTKDFEWRINTNFATYESTVTKlYGDSQNLLVNSFFGVTLNAALDQPYGVI-----------KGTDYVYENGQRVV 864
Cdd:TIGR04056  721 YRNKIGKDFSWSVRGNFTYNKNKILE-LDEGAYLPVKYPYISKEGGPIGQIYGYIadglfkdddspKQTFGNVRPGDIKY 799

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  865 RE-DGLYAKTSSRQEVIGD-INPDWKAGIQNVLSYKNWNFSFLVDVQEGGSVFSGDLYFGMATGLYPITAGLNDLGNPKR 942
Cdd:TIGR04056  800 KDvNGDGKIDDDDRVPIGYsNTPDLTYGFGNSFSYKGFDLSALFQGSGGGDVFNDGRGFYPFNGGDWGNVLKIVADNRWT 879

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  943 DPVTDGPdsggviLPGVQADGTTNTVRADASTYanpygrygnapdaqFVYDASYIKLREMVVSYNLPSDILDTLPFTGVK 1022
Cdd:TIGR04056  880 PENPNAD------YPRLSYGDSNNSNNYQASTR--------------WLEDGSYLRLKNLTLGYTLPKKWLKKIGISNLR 939

                         1050      1060      1070      1080
                   ....*....|....*....|....*....|....*....|....*....
gi 1110846837 1023 FSAVGRNLWIIDKDLPYaDPEsgfsagnVQGFQIGAYPSTKEYGLNVQL 1071
Cdd:TIGR04056  940 VYFSGQNLFTFSKYKGW-DPE-------LQGNDGGAYPLQRTFSFGVNL 980
CirA COG1629
Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];
102-914 1.33e-37

Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];


Pssm-ID: 441236 [Multi-domain]  Cd Length: 644  Bit Score: 150.75  E-value: 1.33e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  102 LDEVVVTALGISRDKKSLGYATQEVDGTEVNTAKEGNFVNSLsGKISGLDIkkSSTLGGSSNVVIRGYSSitGNNQALFV 181
Cdd:COG1629      1 LEEVVVTATRTDESLQDVPGSVSVISREQLEDQPATDLGDLL-RRVPGVSV--TSAGGGAGQISIRGFGG--GGNRVLVL 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  182 IDGVPVNNStfntssqergsngFDYGNAASDINPDDIKSVNVLKGAAAtALYGSRAANGAVIITTKKGATSKGIGVtins 261
Cdd:COG1629     76 VDGVPLNDP-------------SGGDGGLSYIDPEDIERVEVLRGPSS-ALYGSGALGGVINIVTKKPKDGKGGEV---- 137

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  262 SIMVGNYDpdtfaeyqteygqgygpyygngpgngflsgdinqdgtgdlvvpttedasqgsrfdpnlmvygwksfypelds 341
Cdd:COG1629    138 SASYGSYG------------------------------------------------------------------------ 145

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  342 yqqaepwtaakngpssifqtayTDTENISVTSGGENGSARMSYTRFNQTGIMPNSEITRNSLDFSGTLKLTDKLTTSAKA 421
Cdd:COG1629    146 ----------------------TYRASLSLSGGNGKLAYRLSASYRDSDGYRDNSDSDRYNLRAKLGYQLGDDTRLTLSA 203

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  422 IYTKnsglgrygtgydadnlmtnfrewwatnvdlQEQRDAYFQTGRNITWNPFGPDNTKPIYWDnpyftryenynTDERN 501
Cdd:COG1629    204 SYSD------------------------------SDQDSPGYLTLAALRPRGAMDDGTNPYSND-----------TDDNT 242

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  502 RLFGYATIQYD-INDWLDAKGRVSVDTYSELREERNNIGSVDLPEYNRFNINFTELNYDLFLNFDHDFGeFGATGTLGAN 580
Cdd:COG1629    243 RDRYSLSLEYEhLGDGLKLSASAYYRYDDTDLDSDFTPTPADGGTLEQTDFDNRTYGLELRLTYDLGFG-GKHTLLVGLD 321

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  581 YRQTKLSSIYAQTNGGltlpglytlSNSAAPINFPEENESDVRVLGLFATASFDYKDTFFVEGSLRRDTFSTLPDGDNAF 660
Cdd:COG1629    322 YQRQDLDGSGYPLDLG---------SGSLPTLTSGADDDGTTTSLALYAQDTYKLTDKLTLTAGLRYDYVSYDVDDTVTG 392

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  661 NYPAISTsiifskliDSDAITYGKLRAGYgEVGNGAEPY-QLSNTFNAVASFNGTPLYSNPSVAKNANLTEERTNELEIG 739
Cdd:COG1629    393 TDSASGS--------RSYSAFSPSLGLTY-QLSPNLSLYaSYSRGFRAPTFGELYANGTDPYSVGNPDLKPETSTNYELG 463

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  740 LEMSFLEKRLGFDASIYKKETENQIIPVTVSSATGFNSSVVNSGVVEQEGLELSMFGSPIRtkdfEWRINTNFATYESTV 819
Cdd:COG1629    464 LRYRLLDGRLSLSLALFYSDVDNEILSVPLPNDSGFSTYYTNAGKARSYGVELELSYQLTP----GLSLNASYSYTDAKF 539

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  820 TKLYGDSQNLLVNSFFGV-----TLNAALDQPYGVIKGTDYVYENGQRVVREDGLYAKTSSrqeVIGDI--------NPD 886
Cdd:COG1629    540 DDDTDGSADLDGNRLPGVppltaNLGLTYEFPGGWSLGLGVRYVGDRYLDDANTQGAPGGY---TLVDLgagyrfgdNLT 616

                          810       820
                   ....*....|....*....|....*...
gi 1110846837  887 WKAGIQNVLSYKNWNFSFLVDVQEGGSV 914
Cdd:COG1629    617 LSLGVDNLFDKKYATSLSVRASNVRGFL 644
CarbopepD_reg_2 pfam13715
CarboxypepD_reg-like domain; This domain family is found in bacteria, archaea and eukaryotes, ...
 27-107 6.26e-17

CarboxypepD_reg-like domain; This domain family is found in bacteria, archaea and eukaryotes, and is approximately 90 amino acids in length. The family is found in association with pfam07715 and pfam00593.


Pssm-ID: 433425 [Multi-domain]  Cd Length: 88  Bit Score: 76.86  E-value: 6.26e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837   27 VTGTVTDED-GIPLPGVNIVVKGTSTGVQTDFDGNYSIEA-EVGDV-LVYSFVGLKTAEYPVY----NNDKLDVVLEADS 99
Cdd:pfam13715    1 ISGTVVDENtGEPLPGATVYVKGTTKGTVTDADGNFELKNlPAGTYtLVVSFVGYKTQEKKVTvsndNTLDVNFLLKEDA 80


                   ....*...
gi 1110846837  100 AQLDEVVV 107
Cdd:pfam13715   81 LLLDEVVV 88
ligand_gated_channel cd01347
TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) ...
 159-895 2.30e-09

TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.


Pssm-ID: 238657 [Multi-domain]  Cd Length: 635  Bit Score: 61.31  E-value: 2.30e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  159 GGSSNVVIRGYSSitgnNQALFVIDGVPVNNStfntssqeRGSNGFDYgnaaSDINPDDIKSVNVLKGAAAtALYGSRAA 238
Cdd:cd01347     36 GGGSTISIRGFGP----DRTLVLVDGLPLASS--------NYGRGVDL----NTIPPELIERVEVLKGPSS-ALYGSGAI 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  239 NGAVIITTKKGATSKGIGVTinssimvgnydpdtfAEYQTEYGQGygpyygngpgngflsgdiNQDGTGDLVVPTTEDAS 318
Cdd:cd01347     99 GGVVNIITKRPTDEFGGSVT---------------AGYGSDNSGS------------------SGGGGFDVSGALADDGA 145

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  319 QGSRFDPNlmvygwksfypeldsYQQAEPWTAakngpsSIFQTAYTDTENISVTSggengsarmsytrfnqtgimpnsei 398
Cdd:cd01347    146 FGARLYGA---------------YRDGDGTID------GDGQADDSDEERYNVAG------------------------- 179

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  399 trnsldfSGTLKLTDKLTTSAKAIYTKNSGLGRYGTGYdadnlmtnfrewwatnvdlqeqrdayfqTGRNITWNPFGPDN 478
Cdd:cd01347    180 -------KLDWRPDDDTRLTLDAGYQDQDADGPGGTLP----------------------------ANGTGSSLGGGPSS 224

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  479 TKPIYWDNPYFTRYENYNTDERNRLFGYATIQYDINDwldakgrvsvdTYSELREERNNIGSVDLPEYNRFNI------- 551
Cdd:cd01347    225 NTNGDRDWDYRDRYRKRASLGLEHDLNDTGWTLRANL-----------SYSYTDNDGDPLILNGGNNAAGGDLgrsgyss 293

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  552 NFTELNYDLFLNFDHDFGEFGATGTL--GANYRQTKLssiyaqtnggltlpglytlsnsaapinfpeenesDVRVLGLFA 629
Cdd:cd01347    294 ERDTTQLGFDAGLNAPFGTGPVAHTLtlGVEYRREEL----------------------------------DEKQTALYA 339

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  630 TASFDYKDTFFVEGSLRRDTFSTLPDGDNAFNYPAISTsiiFSKLIDSDAITY-----GKLRAGYGEVGNGAEPYQLSNT 704
Cdd:cd01347    340 QDTIELTDDLTLTLGLRYDHYDQDSKDTIAGGTTAKKS---YSHWSPSLGLVYkltdgLSLYASYSQGFRAPSLGELYGG 416

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  705 FNAVASFNGTplysnpsvakNANLTEERTNELEIGLEMSFlEKRLGFDASIYKKETENQIIPVTVSSATGFNSSVVNSGV 784
Cdd:cd01347    417 GSHGGTAAVG----------NPNLKPEKSKQYELGLKYDP-GDGLTLSAALFRIDIKNEIVSTPTNTGLGLVTVYVNGGK 485

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  785 VEQEGLELSMFGSPIRtkdfEWRINTNFATYESTVTKLYGDSQNLLVNSFFGVTLNAALDQPYGVIK---GTDYVYENGQ 861
Cdd:cd01347    486 ARIRGVELEASYDLTD----GLGLTGSYTYTDTEVKRTDGATTGNRLPGIPKHTANLGLDYELPDEGltaGGGVRYRGKQ 561

                          730       740       750       760
                   ....*....|....*....|....*....|....*....|.
gi 1110846837  862 RVVREDGLYAKTSSRQEVIG-----DINPDWK--AGIQNVL 895
Cdd:cd01347    562 YADTANGNNTVKVPGYTLVDlsasyQFTKNLTlrLGVNNLF 602
PRK13486 PRK13486
TonB-dependent receptor;
103-267 3.48e-05

TonB-dependent receptor;


Pssm-ID: 139606 [Multi-domain]  Cd Length: 696  Bit Score: 48.09  E-value: 3.48e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  103 DEVVVTALGISRDKKSLGYATQEVDGTEVNTAKEGNFVNSLSGkISGLDIKKSSTLGGSSNVVIRGYSSitgnNQALFVI 182
Cdd:PRK13486    26 DVMIVSASGYEKKLTNAAASVSVISQEELQSSQYHDLAEALRS-VEGVDVESGTGKTGGLEISIRGMPA----SYTLILI 100

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  183 DGVPVNNSTFNTSsqergsNGFDYGNAASDINPDDIKSVNVLKGAAATaLYGSRAANGAVIITTKKGA----TSKGIGVT 258
Cdd:PRK13486   101 DGVRQGGSSDVTP------NGFSAMNTGFMPPLAAIERIEVIRGPMST-LYGSDAMGGVVNIITRKNAdkwlSSVNAGLN 173


                   ....*....
gi 1110846837  259 INSSIMVGN 267
Cdd:PRK13486   174 LQESNKWGN 182
 
Name Accession Description Interval E-value
OMP_RagA_SusC TIGR04056
TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade ...
 25-1071 2.80e-178

TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 274948 [Multi-domain]  Cd Length: 981  Bit Score: 546.80  E-value: 2.80e-178
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837   25 QTVTGTVTDEDGIPLPGVNIVVKGTSTGVQTDFDGNYSIEAEVGDVLVYSFVGLKTAEYPVYNNDKLDVVLEADSAQLDE 104
Cdd:TIGR04056    1 ITVTGVVVDETGEPLIGASVVVKGTTNGTITDIDGNFSLKVPPGAVLVFSYIGYKTQEVKVKGQKNLNITLKEDTQELDE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  105 VVVTALGIsRDKKSLGYATQEVDGTEVNTAKEGNFVNSLSGKISGLDIKKSS-TLGGSSNVVIRGYSSITGNNQALFVID 183
Cdd:TIGR04056   81 VVVVGYGT-QKKKSLTGAVSTVKAKELKKVPVSNLSNALQGKVAGVIITQSSgEPGGDAEIWIRGISSFGGNNSPLYVID 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  184 GVPvnnstfntssqerGSNGFdygnaaSDINPDDIKSVNVLKGAAATALYGSRAANGAVIITTKKGATSK-----GIGVT 258
Cdd:TIGR04056  160 GVP-------------RDNGL------SDLNPEDIESISVLKDASATAIYGSRGANGVILITTKRGKEGKpkisyNAEFG 220

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  259 INSSIMVGNY-DPDTFAEYQTEYGqgygpyygngpgngflsgdINQDGTGDLVVPTTEDASQGSRFDPNLmvYGWKSFYP 337
Cdd:TIGR04056  221 FSTPTRLPEMlNAYEYAELYNEAL-------------------LNRGSSPPDIYTDEEIEAYRNGLDPDL--YPNTDWQD 279

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  338 ELdsyqqaepwtaakngpssIFQTAYTDTENISVTSGGENGSARMSYTRFNQTGIMPNSEITRNSLDFSGTLKLTDKLTT 417
Cdd:TIGR04056  280 EI------------------FKRTAFNQRHNLSVSGGTEKARYYVSLGYYNEEGILKNSDYKRYNFRANIDAKLTKTLKL 341

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  418 SAKAIYTKNSGLGRYGTGYDADNLMTNFREWWATNVDlqeqrdAYFQTGRNITWNpfgpDNTKPIYwdNPYFTRYENYNT 497
Cdd:TIGR04056  342 SLNVSGSLSKYNNPGGSTSNIWGALMLFPRGTPYSTP------PVYSDGYYPAYN----SGNTSLQ--NPYALLNRGYNE 409

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  498 DERNRLFGYATIQYDINDWLDAKGRVSVDTYSELREERNN-------IGSVDLPEYNRFNINFTELNYDLFLNFDHDFGE 570
Cdd:TIGR04056  410 NERNRLNGNASLEQKITKGLKLKGTFSYDYSNYKNKKYYKnpyyynaTGGANNGYYSESNSRSRNYYLEATLNYNRTFGK 489

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  571 FGATGTLGANYRQTKLSSIYAQTNGgltLPGLYTLSNSAAPINFPEENesdvRVLGLFATASFDYKDTFFVEGSLRRDTF 650
Cdd:TIGR04056  490 HNVSALLGYSQQENKSSSYGGLLDD---LPSLDAGTSDASVSGSDSEY----RLQSLFGRATYSYKDRYLLEFNFRYDGS 562

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  651 STLPDGDNAFNYPAISTSIIFS------KLidSDAITYGKLRAGYGEVGNGAE----PYQLSNTFNAVASFNGTPLYS-- 718
Cdd:TIGR04056  563 SRFAKGNRWGFFPSVSLGWRISeekfmkKL--KKWLSFLKLRASYGIVGNDNIgdryPYLSLYNLGDGGYNFGTNNGTsv 640

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  719 ---NPSVAKNANLTEERTNELEIGLEMSFLEKRLGFDASIYKKETENQIIPVTVSSATGFNSSVVNSGVVEQEGLELSMF 795
Cdd:TIGR04056  641 tgiTESRYGNPNLKWEKTKKWNLGLDLGFFNNRLSLTVDYYYKKTKDILQSRSLPSVTGYSSPYANIGKVKNKGVELSLN 720

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  796 GSPIRTKDFEWRINTNFATYESTVTKlYGDSQNLLVNSFFGVTLNAALDQPYGVI-----------KGTDYVYENGQRVV 864
Cdd:TIGR04056  721 YRNKIGKDFSWSVRGNFTYNKNKILE-LDEGAYLPVKYPYISKEGGPIGQIYGYIadglfkdddspKQTFGNVRPGDIKY 799

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  865 RE-DGLYAKTSSRQEVIGD-INPDWKAGIQNVLSYKNWNFSFLVDVQEGGSVFSGDLYFGMATGLYPITAGLNDLGNPKR 942
Cdd:TIGR04056  800 KDvNGDGKIDDDDRVPIGYsNTPDLTYGFGNSFSYKGFDLSALFQGSGGGDVFNDGRGFYPFNGGDWGNVLKIVADNRWT 879

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  943 DPVTDGPdsggviLPGVQADGTTNTVRADASTYanpygrygnapdaqFVYDASYIKLREMVVSYNLPSDILDTLPFTGVK 1022
Cdd:TIGR04056  880 PENPNAD------YPRLSYGDSNNSNNYQASTR--------------WLEDGSYLRLKNLTLGYTLPKKWLKKIGISNLR 939

                         1050      1060      1070      1080
                   ....*....|....*....|....*....|....*....|....*....
gi 1110846837 1023 FSAVGRNLWIIDKDLPYaDPEsgfsagnVQGFQIGAYPSTKEYGLNVQL 1071
Cdd:TIGR04056  940 VYFSGQNLFTFSKYKGW-DPE-------LQGNDGGAYPLQRTFSFGVNL 980
CirA COG1629
Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];
102-914 1.33e-37

Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];


Pssm-ID: 441236 [Multi-domain]  Cd Length: 644  Bit Score: 150.75  E-value: 1.33e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  102 LDEVVVTALGISRDKKSLGYATQEVDGTEVNTAKEGNFVNSLsGKISGLDIkkSSTLGGSSNVVIRGYSSitGNNQALFV 181
Cdd:COG1629      1 LEEVVVTATRTDESLQDVPGSVSVISREQLEDQPATDLGDLL-RRVPGVSV--TSAGGGAGQISIRGFGG--GGNRVLVL 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  182 IDGVPVNNStfntssqergsngFDYGNAASDINPDDIKSVNVLKGAAAtALYGSRAANGAVIITTKKGATSKGIGVtins 261
Cdd:COG1629     76 VDGVPLNDP-------------SGGDGGLSYIDPEDIERVEVLRGPSS-ALYGSGALGGVINIVTKKPKDGKGGEV---- 137

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  262 SIMVGNYDpdtfaeyqteygqgygpyygngpgngflsgdinqdgtgdlvvpttedasqgsrfdpnlmvygwksfypelds 341
Cdd:COG1629    138 SASYGSYG------------------------------------------------------------------------ 145

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  342 yqqaepwtaakngpssifqtayTDTENISVTSGGENGSARMSYTRFNQTGIMPNSEITRNSLDFSGTLKLTDKLTTSAKA 421
Cdd:COG1629    146 ----------------------TYRASLSLSGGNGKLAYRLSASYRDSDGYRDNSDSDRYNLRAKLGYQLGDDTRLTLSA 203

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  422 IYTKnsglgrygtgydadnlmtnfrewwatnvdlQEQRDAYFQTGRNITWNPFGPDNTKPIYWDnpyftryenynTDERN 501
Cdd:COG1629    204 SYSD------------------------------SDQDSPGYLTLAALRPRGAMDDGTNPYSND-----------TDDNT 242

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  502 RLFGYATIQYD-INDWLDAKGRVSVDTYSELREERNNIGSVDLPEYNRFNINFTELNYDLFLNFDHDFGeFGATGTLGAN 580
Cdd:COG1629    243 RDRYSLSLEYEhLGDGLKLSASAYYRYDDTDLDSDFTPTPADGGTLEQTDFDNRTYGLELRLTYDLGFG-GKHTLLVGLD 321

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  581 YRQTKLSSIYAQTNGGltlpglytlSNSAAPINFPEENESDVRVLGLFATASFDYKDTFFVEGSLRRDTFSTLPDGDNAF 660
Cdd:COG1629    322 YQRQDLDGSGYPLDLG---------SGSLPTLTSGADDDGTTTSLALYAQDTYKLTDKLTLTAGLRYDYVSYDVDDTVTG 392

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  661 NYPAISTsiifskliDSDAITYGKLRAGYgEVGNGAEPY-QLSNTFNAVASFNGTPLYSNPSVAKNANLTEERTNELEIG 739
Cdd:COG1629    393 TDSASGS--------RSYSAFSPSLGLTY-QLSPNLSLYaSYSRGFRAPTFGELYANGTDPYSVGNPDLKPETSTNYELG 463

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  740 LEMSFLEKRLGFDASIYKKETENQIIPVTVSSATGFNSSVVNSGVVEQEGLELSMFGSPIRtkdfEWRINTNFATYESTV 819
Cdd:COG1629    464 LRYRLLDGRLSLSLALFYSDVDNEILSVPLPNDSGFSTYYTNAGKARSYGVELELSYQLTP----GLSLNASYSYTDAKF 539

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  820 TKLYGDSQNLLVNSFFGV-----TLNAALDQPYGVIKGTDYVYENGQRVVREDGLYAKTSSrqeVIGDI--------NPD 886
Cdd:COG1629    540 DDDTDGSADLDGNRLPGVppltaNLGLTYEFPGGWSLGLGVRYVGDRYLDDANTQGAPGGY---TLVDLgagyrfgdNLT 616

                          810       820
                   ....*....|....*....|....*...
gi 1110846837  887 WKAGIQNVLSYKNWNFSFLVDVQEGGSV 914
Cdd:COG1629    617 LSLGVDNLFDKKYATSLSVRASNVRGFL 644
FepA COG4771
Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and ...
 92-821 1.11e-31

Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism];


Pssm-ID: 443803 [Multi-domain]  Cd Length: 612  Bit Score: 132.29  E-value: 1.11e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837   92 DVVLEADSAQLDEVVVTALGISRDKKSLGYATQEVDGTEVNTAKEGNFVNSLSgKISGLDIKKSSTLGGSSNVVIRGYSS 171
Cdd:COG4771     17 ADALAEDATELEEVVVTATRTEQSLSDAPASVSVITAEEIEKLGATDLADALR-LLPGVSVTRSGGRGGSSGISIRGLGG 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  172 itgnNQALFVIDGVPVNNSTFNTssqergsngfdyGNAASDINPDDIKSVNVLKGAAAtALYGSRAANGAVIITTKKGAT 251
Cdd:COG4771     96 ----DRVLVLIDGVPVNNPALGG------------GGDLSYIPPDDIERIEVIRGPAS-ALYGSDAIGGVINIITKKPTD 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  252 SKGIGVTinssimvgnydpdtfaeyqteygqgygpyygngpgngfLSGDINQDGTGDLvvpttedasqgsrfdpnlmvyg 331
Cdd:COG4771    159 ELEGSVS--------------------------------------LGYGSNGNGTYSG---------------------- 178

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  332 wksfypeldsyqqaepwtaakngpssifqtaytdteNISVTSGGENGSARMSYTRFNQTGimpnseitrnsldfsgtlkl 411
Cdd:COG4771    179 ------------------------------------SLSLGGPGDKLSFLLSGSYRDRDG-------------------- 202

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  412 tdklttsakaIYTKNSGLGRYGTGYDADNLMTNFrewwatNVDLQEQRDAYFQTGRNITWNPFGPDNTKPIYWDNPYfTR 491
Cdd:COG4771    203 ----------YLDYRNGGFVGNSGYERYNLNAKL------GYRLSDNHRLSLSGGYSRQDRDGGPPTLGDTEISSDN-AG 265

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  492 YENYNTDERNRLFGYatiQYDINDWLDAkgRVSVDTYSELREERNNIGSVDLPEYNRFNINFTELNYDLFLNFDHDFgef 571
Cdd:COG4771    266 DRDTTTDRGNYSLRY---NGDLGDNLDL--SLYYSRTDRDSTNGSLGGSTGSFSDSDDTTYGLELDLTYPLGGNHTL--- 337

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  572 gatgTLGANYRQTKLSSiyaqtnggltlpglytlsnsaapINFPEENESDVRVLGLFATASFDYKDTFFVEGSLRRDTFS 651
Cdd:COG4771    338 ----TLGAEYRYDDLDS-----------------------SSFLGGADASRDTYGLFAQDEWKLTDKLTLTAGLRYDYYS 390

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  652 TL-PDGDNAFNyPAISTSIIFsklidSDAITygkLRAGYGEVGNGAEPYQLSNTFNAVASFNGTPlysnpsvakNANLTE 730
Cdd:COG4771    391 TFgASNYTAFS-PRLGLRYDL-----SDNLT---LRASYGRGFRAPSLAELYGSGTGTPGRYVLG---------NPDLKP 452

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  731 ERTNELEIGLEMSFLEKRLGFDASIYKKETENQIIPVTVSSATGFNSSVVNSGVVEQEGLELSMFGSPIRTkdfeWRINT 810
Cdd:COG4771    453 ETSDNYELGLEYRLGNGGLSLSLTGFYTDIKDLIVLVPVGPGPGDVLQYENVGKARTYGLELELKYRLGKG----LTLTA 528

                          730
                   ....*....|.
gi 1110846837  811 NFATYESTVTK 821
Cdd:COG4771    529 SYTYLDSKIDD 539
BtuB COG4206
Outer membrane cobalamin receptor protein BtuB [Coenzyme transport and metabolism];
105-269 1.74e-29

Outer membrane cobalamin receptor protein BtuB [Coenzyme transport and metabolism];


Pssm-ID: 443355 [Multi-domain]  Cd Length: 276  Bit Score: 119.21  E-value: 1.74e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  105 VVVTALGISRDKKSLGYATQEVDGTEVNTAKEGNFVNSLSgKISGLDIKKSSTLGGSSNVVIRGYSSitgnNQALFVIDG 184
Cdd:COG4206      1 VVVTATRLEQSKSDLTGSVTVIDAEELERSGATSLADALR-RVPGVQVSSSGGPGSAASISIRGLGS----NQTLVLIDG 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  185 VPVNNSTFNtssqergsngfdyGNAASDINPDDIKSVNVLKGAAAtALYGSRAANGAVIITTKKGATSKGIGVTINssim 264
Cdd:COG4206     76 VPLNDPSLG-------------GVDLSLIPPDDIERIEVLKGAAS-ALYGSDAIGGVINITTKKGKKGFKGSVSAS---- 137


                   ....*
gi 1110846837  265 VGNYD 269
Cdd:COG4206    138 YGSFG 142
CarbopepD_reg_2 pfam13715
CarboxypepD_reg-like domain; This domain family is found in bacteria, archaea and eukaryotes, ...
 27-107 6.26e-17

CarboxypepD_reg-like domain; This domain family is found in bacteria, archaea and eukaryotes, and is approximately 90 amino acids in length. The family is found in association with pfam07715 and pfam00593.


Pssm-ID: 433425 [Multi-domain]  Cd Length: 88  Bit Score: 76.86  E-value: 6.26e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837   27 VTGTVTDED-GIPLPGVNIVVKGTSTGVQTDFDGNYSIEA-EVGDV-LVYSFVGLKTAEYPVY----NNDKLDVVLEADS 99
Cdd:pfam13715    1 ISGTVVDENtGEPLPGATVYVKGTTKGTVTDADGNFELKNlPAGTYtLVVSFVGYKTQEKKVTvsndNTLDVNFLLKEDA 80


                   ....*...
gi 1110846837  100 AQLDEVVV 107
Cdd:pfam13715   81 LLLDEVVV 88
Plug pfam07715
TonB-dependent Receptor Plug Domain; The Plug domain has been shown to be an independently ...
 115-241 4.80e-13

TonB-dependent Receptor Plug Domain; The Plug domain has been shown to be an independently folding subunit of the TonB-dependent receptors. It acts as the channel gate, blocking the pore until the channel is bound by ligand. At this point it under goes conformational changes opens the channel.


Pssm-ID: 462243 [Multi-domain]  Cd Length: 107  Bit Score: 66.14  E-value: 4.80e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  115 DKKSLGYATQEVDGTEVNTAKEGNFVNSLSGkISGLDIKkSSTLGGSSNVVIRGYSSitgnNQALFVIDGVPVNNstfnt 194
Cdd:pfam07715    1 DLRDTPGSVSVVTAEDIEDQGATNLADALRG-VPGVSVS-SGGGGGGSSISIRGFGS----NRVLVLVDGVPLNS----- 69

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1110846837  195 ssqergsnGFDYGNAASDINPDDIKSVNVLKGaAATALYGSRAANGA 241
Cdd:pfam07715   70 --------GGGGSVDLNSIDPEDIERVEVLKG-PASALYGSGAIGGV 107
SusC_RagA_signa TIGR04057
TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; This model ...
 217-247 3.17e-11

TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; This model describes a 31-residue signature region of the SusC/RagA family of outer membrane proteins from the Bacteriodetes. While many TonB-dependent outer membrane receptors are associated with siderophore import, this family seems to include generalized nutrient receptors that may convey fairly large oligomers of protein or carbohydrate. This family occurs in high copy numbers in the most abundant species of the human gut microbiome.


Pssm-ID: 274949 [Multi-domain]  Cd Length: 31  Bit Score: 58.75  E-value: 3.17e-11
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1110846837  217 DIKSVNVLKGAAATALYGSRAANGAVIITTK 247
Cdd:TIGR04057    1 DIESISVLKDASAAAIYGSRGANGVILITTK 31
TonB_dep_Rec pfam00593
TonB dependent receptor; This model now only covers the conserved part of the barrel structure.
 462-870 1.74e-10

TonB dependent receptor; This model now only covers the conserved part of the barrel structure.


Pssm-ID: 395474 [Multi-domain]  Cd Length: 475  Bit Score: 64.79  E-value: 1.74e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  462 YFQTGRNITWNPFGPDNTKPIYWDNPYFTRYENYNTDERNRLFGYatiQYDINDWLDAKGRVSVDTYSELREERNNIGSV 541
Cdd:pfam00593   23 RYTDGLDLGLTLDGYGNDGGYLGDRPLYYGRDYSDTDRKRLSLGY---DYDLGDGLSWLSTLRLGLRYSSLDGDYTSNSS 99

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  542 DLPEYNRFNINFTELNYDLFLNFDHDFGEFGATGTLGANYRQTKLSSIYAQTNGGLTLPGLYTLSNSAapinfpeeNESD 621
Cdd:pfam00593  100 GLSGAGDYLSDDRLYGLYGLDGDLELSLDLSHDLLLGVELRTAGLDYRRLDDDAYDPYDPANPSSSSY--------SDTT 171

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  622 VRVLGLFATASFDYKDTFFVEGSLRRDTFSTLPDGDNAFNYPAISTSIIFS-KL-IDSDAITYGKLRAGYGEVGNGAEPY 699
Cdd:pfam00593  172 TDSYGLYLQDNIKLTDRLTLTLGLRYDHYSTDGDDGNGGGDNFSRSYSAFSpRLgLVYKPTDNLSLYASYSRGFRAPSLG 251

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  700 QLSNTFNAVASFNGTplysnpsvAKNANLTEERTNELEIGLEmsFLEKRLGFDASIYKKETENQIIPV-TVSSATGFNSS 778
Cdd:pfam00593  252 ELYGSGSGGGGGAVA--------GGNPDLKPETSDNYELGLK--YDDGRLSLSLALFYIDIKNLITSDpDGPGLGGTVYT 321

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  779 VVNSGVVEQEGLELSmfgspIRTKDFEWRINTNFATYESTVTKLYGDSQNLLVNSFFGVTLNAALD-----QPYGVIKGT 853
Cdd:pfam00593  322 YTNVGKARIRGVELE-----LSGRLWGLGLSGGGYTYTDADDDADADDTGNPLPNVPRHTANLGLTydfplGGWGARLGA 396

                          410
                   ....*....|....*..
gi 1110846837  854 DYVYENGQRVVREDGLY 870
Cdd:pfam00593  397 RYVGSGERRYGDAANTF 413
ligand_gated_channel cd01347
TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) ...
 159-895 2.30e-09

TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.


Pssm-ID: 238657 [Multi-domain]  Cd Length: 635  Bit Score: 61.31  E-value: 2.30e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  159 GGSSNVVIRGYSSitgnNQALFVIDGVPVNNStfntssqeRGSNGFDYgnaaSDINPDDIKSVNVLKGAAAtALYGSRAA 238
Cdd:cd01347     36 GGGSTISIRGFGP----DRTLVLVDGLPLASS--------NYGRGVDL----NTIPPELIERVEVLKGPSS-ALYGSGAI 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  239 NGAVIITTKKGATSKGIGVTinssimvgnydpdtfAEYQTEYGQGygpyygngpgngflsgdiNQDGTGDLVVPTTEDAS 318
Cdd:cd01347     99 GGVVNIITKRPTDEFGGSVT---------------AGYGSDNSGS------------------SGGGGFDVSGALADDGA 145

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  319 QGSRFDPNlmvygwksfypeldsYQQAEPWTAakngpsSIFQTAYTDTENISVTSggengsarmsytrfnqtgimpnsei 398
Cdd:cd01347    146 FGARLYGA---------------YRDGDGTID------GDGQADDSDEERYNVAG------------------------- 179

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  399 trnsldfSGTLKLTDKLTTSAKAIYTKNSGLGRYGTGYdadnlmtnfrewwatnvdlqeqrdayfqTGRNITWNPFGPDN 478
Cdd:cd01347    180 -------KLDWRPDDDTRLTLDAGYQDQDADGPGGTLP----------------------------ANGTGSSLGGGPSS 224

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  479 TKPIYWDNPYFTRYENYNTDERNRLFGYATIQYDINDwldakgrvsvdTYSELREERNNIGSVDLPEYNRFNI------- 551
Cdd:cd01347    225 NTNGDRDWDYRDRYRKRASLGLEHDLNDTGWTLRANL-----------SYSYTDNDGDPLILNGGNNAAGGDLgrsgyss 293

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  552 NFTELNYDLFLNFDHDFGEFGATGTL--GANYRQTKLssiyaqtnggltlpglytlsnsaapinfpeenesDVRVLGLFA 629
Cdd:cd01347    294 ERDTTQLGFDAGLNAPFGTGPVAHTLtlGVEYRREEL----------------------------------DEKQTALYA 339

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  630 TASFDYKDTFFVEGSLRRDTFSTLPDGDNAFNYPAISTsiiFSKLIDSDAITY-----GKLRAGYGEVGNGAEPYQLSNT 704
Cdd:cd01347    340 QDTIELTDDLTLTLGLRYDHYDQDSKDTIAGGTTAKKS---YSHWSPSLGLVYkltdgLSLYASYSQGFRAPSLGELYGG 416

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  705 FNAVASFNGTplysnpsvakNANLTEERTNELEIGLEMSFlEKRLGFDASIYKKETENQIIPVTVSSATGFNSSVVNSGV 784
Cdd:cd01347    417 GSHGGTAAVG----------NPNLKPEKSKQYELGLKYDP-GDGLTLSAALFRIDIKNEIVSTPTNTGLGLVTVYVNGGK 485

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  785 VEQEGLELSMFGSPIRtkdfEWRINTNFATYESTVTKLYGDSQNLLVNSFFGVTLNAALDQPYGVIK---GTDYVYENGQ 861
Cdd:cd01347    486 ARIRGVELEASYDLTD----GLGLTGSYTYTDTEVKRTDGATTGNRLPGIPKHTANLGLDYELPDEGltaGGGVRYRGKQ 561

                          730       740       750       760
                   ....*....|....*....|....*....|....*....|.
gi 1110846837  862 RVVREDGLYAKTSSRQEVIG-----DINPDWK--AGIQNVL 895
Cdd:cd01347    562 YADTANGNNTVKVPGYTLVDlsasyQFTKNLTlrLGVNNLF 602
Fiu COG4774
Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism];
159-821 4.26e-09

Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism];


Pssm-ID: 443806 [Multi-domain]  Cd Length: 639  Bit Score: 60.66  E-value: 4.26e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  159 GGSSNVVIRGYSSITGnnqalFVIDGVPVNNSTFntssqergsngfdygnaasdINPDDIKSVNVLKGAAAtALYGSRAA 238
Cdd:COG4774     47 GNGDSFSIRGFSASGD-----IYVDGLRDPGQYR--------------------RDTFNLERVEVLKGPAS-VLYGRGSP 100

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  239 NGAVIITTKK-GATSKG-IGVTInssimvgnydpDTFAEYQteygqgygpyygngpgngfLSGDINQdgtgdlvvPTTED 316
Cdd:COG4774    101 GGVINLVTKRpTDEPFTeVTLTY-----------GSDGQRR-------------------ATLDVNG--------PLGDD 142

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  317 AsqGSRFdpNLMvygwksfypeldsYQQAEPWTaakngpssifqtaytdtenisvtsggengsarmSYTRFNQTGIMPns 396
Cdd:COG4774    143 L--AYRL--NGM-------------YRDSDSYR---------------------------------DGVDNDRWGIAP-- 170

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  397 eitrnSLDFsgtlKLTDKLTTSAKAIYTKNSGLGRYGTGYDADNLmtnfrewwATNVDlqeqRDAYFqtgrnitwnpfgp 476
Cdd:COG4774    171 -----SLTW----RLGDRTRLTLDYEYQDDDRTPDYGVPAVANGR--------PVDVD----RSTFY------------- 216

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  477 dntkpiywdnpyftrYENYNTDERNRLFGYATIQYDINDWLDAKGRVSVDTYSELREERNNIGSVDLPEYNR----FNIN 552
Cdd:COG4774    217 ---------------GQPDDYSDSETDSATLRLEHDFNDNWTLRNALRYSDYDRDYRNTYPTGGNATGTVTRsayrRDQD 281

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  553 FTELNYDLFLNFDHDFGEFGATGTLGANYRQTKLSSIYAQTNGGLTLPGLYTLSNSAAPINFP---EENESDVRVLGLFA 629
Cdd:COG4774    282 NDTLSNQTDLTGKFDTGGVKHTLLAGVEYSREDSDNARYSGGGTAPTVNLYNPVYGAPVTGPTlggADNDSRTDTTGLYL 361

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  630 --TASFDykDTFFVEGSLRRDTFSTlpDGDNAFNYPAISTSiifskliDSDAITYgklRAG--YgEVGNGAEPY-QLSNT 704
Cdd:COG4774    362 qdTISLT--DRWSLLAGLRYDRFDT--DYTDRTTGATTSSY-------DDSAFSP---RAGlvY-KPTPNLSLYaSYSTS 426

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  705 FNAVAsfnGTPLYSNpsvaKNANLTEERTNELEIGLEMSFLEKRLGFDASIYkkETENQIIPVTVSSATGFnssVVNSGV 784
Cdd:COG4774    427 FNPGG---GAPSLSN----AGQALDPEKSRQYEVGVKWDLLDGRLSLTAALF--RIEKTNVRTTDPANPGV---YVQTGE 494

                          650       660       670
                   ....*....|....*....|....*....|....*..
gi 1110846837  785 VEQEGLELSMFGSPIRtkdfEWRINTNFATYESTVTK 821
Cdd:COG4774    495 QRSRGVELEATGELTP----GWSVLAGYTYLDAEITK 527
FhuE COG4773
Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion ...
 460-821 1.28e-08

Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism];


Pssm-ID: 443805 [Multi-domain]  Cd Length: 692  Bit Score: 59.14  E-value: 1.28e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  460 DAYFQTGRNITWNPFGPDNTKPIYWdnPYFTRY-ENYNTDERNRLFGYATIQYDINDWLDAKGRVSvdtYSELREERNNI 538
Cdd:COG4773    244 GAEYQDDDSTGDRGFLPLDGTLLDL--PRSTNLgEPWDYYDTETTTLFAELEHRFNDDWSLRANAR---YSDSDRDGRSA 318

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  539 GSVDLPE---------YNRFNINFTELNYDLFLNFDHDFGEFGATGTLGANYRQTKLSSIYAQTNGG-LTLPGLYTLSNS 608
Cdd:COG4773    319 YAYGAPDaatgtltryASARDGDSRSDSLDANLNGKFETGGLEHTLLVGADYSRYDSDSDSATAGTInIYNPVYGNLPEP 398

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  609 AAPINFpeeNESDVRVLGLFATASFDYKDTFFVEGSLRRDTFSTlpdgdNAFNYPAISTSIifsklIDSDAITYgklRAG 688
Cdd:COG4773    399 DFDASD---TDTTTRQTGLYAQDQISLTDRLSLLLGGRYDWYET-----DSTNRLGGSTTS-----YDDSAFTP---RAG 462

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  689 --YgEVGNGAEPY-QLSNTF--NAVASFNGTPLysNPSVAKNanlteertneLEIGLEMSFLEKRLGFDASIYKKETENq 763
Cdd:COG4773    463 lvY-DLTPGLSLYaSYSESFepQSGADNNGNPL--DPETGKQ----------YEAGVKGELFDGRLNATLAVFDITQKN- 528

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1110846837  764 iIPVTVSSATGFNssvVNSGVVEQEGLELSMFGSPIRTkdfeWRINTNFATYESTVTK 821
Cdd:COG4773    529 -VATTDPDNPNFY---VQVGEVRSRGVELELSGELTPG----LNLIAGYTYTDAKITK 578
CarboxypepD_reg pfam13620
Carboxypeptidase regulatory-like domain;
26-100 2.63e-08

Carboxypeptidase regulatory-like domain;


Pssm-ID: 433354 [Multi-domain]  Cd Length: 81  Bit Score: 51.90  E-value: 2.63e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837   26 TVTGTVTDEDGIPLPGVNIVVKGTSTG----VQTDFDGNYSIEA-EVGD-VLVYSFVGLKTAEYPvynndklDVVLEADS 99
Cdd:pfam13620    1 TISGTVTDPSGAPVPGATVTVTNTDTGtvrtTTTDADGRYRFPGlPPGTyTVTVSAPGFKTATRT-------GVTVTAGQ 73


                   .
gi 1110846837  100 A 100
Cdd:pfam13620   74 T 74
FecA COG4772
Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism];
96-825 6.72e-06

Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism];


Pssm-ID: 443804 [Multi-domain]  Cd Length: 681  Bit Score: 50.31  E-value: 6.72e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837   96 EADSAQLDEVVVTALGISRDK-KSLGYATQEVDGTEVntakEGNFVNSLS---GKISGLDIKKSSTLGGSSNVVIRGySS 171
Cdd:COG4772     17 AEAATTLETVVVTGSRAAEARlKDVPGSVSVVDREEL----ENQAATSLRevlRRVPGVNVQEEDGFGLRPNIGIRG-LG 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  172 ITGNNQALFVIDGVPVNNSTfntssqergsngfdYGNAASDINPD--DIKSVNVLKGAAAtALYGSRAANGAVIITTKKG 249
Cdd:COG4772     92 PRRSRGITLLEDGIPIAPAP--------------YGDPAAYYFPDleRMERIEVLRGAAA-LRYGPQTVGGAINFVTRTI 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  250 atskgigvtinssimvgnydPDTFaeyqteygqgygpyygngpgngflSGDINQDGTGDlvvpttedasqgsrfdpnlmv 329
Cdd:COG4772    157 --------------------PTAF------------------------GGELRVTGGSF--------------------- 171

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  330 ygwksfypeldsyqqaepwtaakngpssifqtaytDTENISVTSGGENGSAR--MSYTRFNQTGIMPNSEITRNSLDFSG 407
Cdd:COG4772    172 -----------------------------------GYRRTHASVGGTVGNFGylVEYSRKRGDGFRDNSGFDINDFNAKL 216

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  408 TLKLTDKLTTSAKAIYtknsglgrygtgYDADNlmtnfrewwatnvdlqeqrdayfQTGRNITWNPFgpdntkpiyWDNP 487
Cdd:COG4772    217 GYRLSDRQELTLKFQY------------YDEDA-----------------------NTPGGLTDAQF---------DADP 252

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  488 YFtRYENYNTDERNRLFGYATIQYDINDwldaKGRVSVDTYSELREE----RNNIGSVDLPEYNRFNINFTELNYDLFLN 563
Cdd:COG4772    253 RQ-SYRPADQFDTRRTQLSLRYEHQLSD----NTTLTTTAYYNDFSRnwyiRQNTADPNTPGLGLRGNPRGYRSYGIEPR 327

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  564 FDHDFGEFGATGTL--GANYRQTKLSSIYAQTNGGLTLPGLYTLSNsaapinfpeeNESDVRVLGLFATASFDYKDTFFV 641
Cdd:COG4772    328 LTHRFELGGVPHTLevGLRYHREEEDRKQYVNTYGQGRSGAGLRRD----------RRFSADALAAYAQNRFELTGRLTL 397

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  642 EGSLRRDTFSTlpDGDNAFNY---PAISTSIIFSKLIDSDAITYgKLRAG---YGEVGNGAEPYqlsnTFNAVASFNGTp 715
Cdd:COG4772    398 TPGLRYEHIRR--DRTDRYSTrtgGDDSGSNSYSEFLPGLGLLY-QLTDNlqlYANVSRGFEPP----TFGDLAYGNGG- 469

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  716 lysnpsvakNANLTEERTNELEIGLEmSFLEKRLGFDASIYKKETENQIipVTVSSATGFNSSVVNSGVVEQEGLELSMF 795
Cdd:COG4772    470 ---------NPDLKPEKSWNYELGTR-GRIGNGLSAEVALFYIDYDNEL--GSCSAAGGDRSTFTNAGETRHQGLELALD 537

                          730       740       750
                   ....*....|....*....|....*....|....
gi 1110846837  796 GSPIRTKDFEWRINTNF----ATYESTVTKLYGD 825
Cdd:COG4772    538 YDLLKGGGLGLPLFAAYtytdAEFTSDFGPVFAG 571
PRK13486 PRK13486
TonB-dependent receptor;
103-267 3.48e-05

TonB-dependent receptor;


Pssm-ID: 139606 [Multi-domain]  Cd Length: 696  Bit Score: 48.09  E-value: 3.48e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  103 DEVVVTALGISRDKKSLGYATQEVDGTEVNTAKEGNFVNSLSGkISGLDIKKSSTLGGSSNVVIRGYSSitgnNQALFVI 182
Cdd:PRK13486    26 DVMIVSASGYEKKLTNAAASVSVISQEELQSSQYHDLAEALRS-VEGVDVESGTGKTGGLEISIRGMPA----SYTLILI 100

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  183 DGVPVNNSTFNTSsqergsNGFDYGNAASDINPDDIKSVNVLKGAAATaLYGSRAANGAVIITTKKGA----TSKGIGVT 258
Cdd:PRK13486   101 DGVRQGGSSDVTP------NGFSAMNTGFMPPLAAIERIEVIRGPMST-LYGSDAMGGVVNIITRKNAdkwlSSVNAGLN 173


                   ....*....
gi 1110846837  259 INSSIMVGN 267
Cdd:PRK13486   174 LQESNKWGN 182
PRK13524 PRK13524
FepA family TonB-dependent siderophore receptor;
96-249 1.69e-04

FepA family TonB-dependent siderophore receptor;


Pssm-ID: 237410 [Multi-domain]  Cd Length: 744  Bit Score: 45.79  E-value: 1.69e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837   96 EADSAQLDEVVVTALGISRdkKSLGYATqeVDGTEVNTAKEGNFVNSLSGKISGLDIKKSSTLGGSSN---VVIRGyssi 172
Cdd:PRK13524    32 DTPASHEDTIVVTAAEQNL--QAPGVST--ITAEDIRKRPPANDVSEIIRTMPGVNLTGNSTSGQRGNnrqIDIRG---- 103

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  173 TGNNQALFVIDGVPVN--NSTFNTSSQERGSNGfdygnaasDIN---PDDIKSVNVLKGAAAtALYGSRAANGAVIITTK 247
Cdd:PRK13524   104 MGPENTLILIDGKPVSsrNSVRYGWRGERDTRG--------DTNwvpPEMIERIEVLRGPAA-ARYGNGAAGGVVNIITK 174


                   ..
gi 1110846837  248 KG 249
Cdd:PRK13524   175 KP 176
TonB-siderophor TIGR01783
TonB-dependent siderophore receptor; This subfamily model encompasses a wide variety of ...
 146-249 2.81e-04

TonB-dependent siderophore receptor; This subfamily model encompasses a wide variety of TonB-dependent outer membrane siderophore receptors. It has no overlap with TonB receptors known to transport other substances, but is likely incomplete due to lack of characterizations. It is likely that genuine siderophore receptors will be identified which score below the noise cutoff to this model at which point the model should be updated. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins]


Pssm-ID: 273805 [Multi-domain]  Cd Length: 651  Bit Score: 45.10  E-value: 2.81e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  146 KISGLDIKKSSTLGGSSNVVIRGYSSITGNNQALFviDGVPvnnstfntssqergsngFDYGNAASDINPDDIKSVNVLK 225
Cdd:TIGR01783   28 RVPGVVVGGSGGTTQFGNITIRGFGLEVDIDNVYL--DGVP-----------------LLSRGNLAIVDPAMVERVEVLR 88

                           90       100
                   ....*....|....*....|....
gi 1110846837  226 GAAAtALYGSRAANGAVIITTKKG 249
Cdd:TIGR01783   89 GPAS-LLYGGSAPGGVINIVTKRP 111
PRK09840 PRK09840
catecholate siderophore receptor Fiu; Provisional
 718-820 3.24e-04

catecholate siderophore receptor Fiu; Provisional


Pssm-ID: 182105 [Multi-domain]  Cd Length: 761  Bit Score: 44.80  E-value: 3.24e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  718 SNPSVAKNANLTEERTNELEIGLEMSFLEKRLGFDASIYKKETENQIipvtVSSATGfnsSVVNSGVVEQEGLELSMFGS 797
Cdd:PRK09840   552 GSGNSANRTDFKPQKANTSEIGTKWQVLDKRLLLTAALFRTDIENEV----EQNDDG---TYSQYGKKRVEGYELSVAGN 624

                           90       100
                   ....*....|....*....|...
gi 1110846837  798 PirTKDfeWRINTNFATYESTVT 820
Cdd:PRK09840   625 I--TPA--WQVIAGYTQQKATVK 643
PRK13528 PRK13528
outer membrane receptor FepA; Provisional
 140-248 3.79e-04

outer membrane receptor FepA; Provisional


Pssm-ID: 237413 [Multi-domain]  Cd Length: 727  Bit Score: 44.36  E-value: 3.79e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837  140 VNSLSG---KISGLDIKKSSTLGGSSN---VVIRGyssiTGNNQALFVIDGVPVN--NSTFNTSSQERGSNGfdygnaas 211
Cdd:PRK13528    67 VNDLSDiirKMPGVNLTGNSASGTRGNnrqIDIRG----MGPENTLILIDGVPVTsrNSVRYSWRGERDTRG-------- 134

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1110846837  212 DIN---PDDIKSVNVLKGAAAtALYGSRAANGAVIITTKK 248
Cdd:PRK13528   135 DTNwvpPEMVERIEVIRGPAA-ARYGSGAAGGVVNIITKR 173
PRK10064 PRK10064
catecholate siderophore receptor CirA; Provisional
 96-248 3.39e-03

catecholate siderophore receptor CirA; Provisional


Pssm-ID: 236646 [Multi-domain]  Cd Length: 663  Bit Score: 41.41  E-value: 3.39e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110846837   96 EADSAQLDEVVVTALGISRDKKSLGYATQEVDGTEVNTAKEGNFVNSLsGKISGLDIKKSSTlgGSSNVVIRGYSSitgn 175
Cdd:PRK10064    24 LAVDDDGETMVVTASAVEQNLKDAPASISVITQEDLQRKPVQNLKDVL-KEVPGVQLTNEGD--NRKGVSIRGLDS---- 96

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1110846837  176 NQALFVIDGVPVNNstfnTSSQERGsNGFDYGNaasdINPDDIKSVNVLKGAAATaLYGSRAANGAVIITTKK 248
Cdd:PRK10064    97 SYTLILIDGKRVNS----RNAVFRH-NDFDLNW----IPVDAIERIEVVRGPMSS-LYGSDALGGVVNIITKK 159
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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