NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1108551342|gb|APE42964|]
View 

methyltransferase [Sulfitobacter alexandrii]

Protein Classification

trimethylamine methyltransferase family protein( domain architecture ID 10533356)

trimethylamine methyltransferase family protein similar to Desulfitobacterium hafniense glycine betaine methyltransferase that likely methylates a corrinoid protein, likely the adjacently encoded DSY3155, with glycine betaine, to then supply methyl groups to tetrahydrofolate for ultimate conversion to carbon dioxide

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MTTB pfam06253
Trimethylamine methyltransferase (MTTB); This family consists of several trimethylamine ...
 11-515 0e+00

Trimethylamine methyltransferase (MTTB); This family consists of several trimethylamine methyltransferase (MTTB) (EC:2.1.1.-) proteins from numerous Rhizobium and Methanosarcina species.


:

Pssm-ID: 428852  Cd Length: 502  Bit Score: 788.39  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108551342  11 RSGGRAGAKTRRGSAVIEQMpWNPPVNLDRPTEPLTEEGVLAIHDGAMRILEEIGIEFLNPEAAGILARAGCTVDGDNVR 90
Cdd:pfam06253   1 RRGGRAARRARRAAPRADQS-WPYIVRGIPPYEPLSEEGIAAIEEAAMRILEEIGIEFRDPEALELWRAAGADVDGERVR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108551342  91 MGRDMVMEWVGKAPSEFTLTPRNPDRRITVGGRNLLFGNVSSPPNYWDMGIGRKvPGTREMCRDLLRLTQYFNCIHFAGG 170
Cdd:pfam06253  80 FDRGLVRELLATAPRQFTLHARNPERDVVIGGNNLVFAPVYGPPFVRDLDRGRR-YGTLADFRNFVKLTQMFPWLHHSGG 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108551342 171 YPVEPVDVHASVRHLDVLYDKLTLTDKVMHAYSLGKERVEDVMEMVRISQGLTHDEFDAKPRMYTNINSTSPLKHDHPMM 250
Cdd:pfam06253 159 TVVEPVDVPVNKRHLDMLYAHLTLSDKPFMGSVTGPERAEDSIEMCRILFGLSFAEFRANPVMTTNINVNSPLTFDETML 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108551342 251 DGWMRLARRGQGLVVTPFTLAGAMAPVTMAGAVAQSLAEALCAVVLAQIIRPGCPVAIGTFTSNVDMKSGAPAFGTPEYM 330
Cdd:pfam06253 239 GGLRVYARAGQAVIVTPFILAGAMAPVTVAGALAQSLAEALAGIALTQLVRPGAPVIYGTFTSNVDMKSGAPTFGTPEPA 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108551342 331 RATQMTGQMARFYGLPLRSSGV-CAANVPDGQAMWETSNSLWAAVQSGTNMVYHAAGWLEGGLIASPEKFIMDCEVLQQI 409
Cdd:pfam06253 319 LATYVAGQLARRYGLPWRSSGGlTASKIPDAQAAYESAMSLWAALLAGANFVLHAAGWLEGGLTASYEKFVMDADMLGMI 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108551342 410 QRYMQPeiCATGPDEIALDAIKAVGNAGHFFGIQHTQDRYTTAFYQPFLSDWKNYEGWEAAGSVWTPERAHHMFKEIVTS 489
Cdd:pfam06253 399 HRLLAG--IDVSDDALAMDAIREVGPGGHFLGCAHTQARYETAFYRPELSDWRNFETWEEEGAKDTAERANRRWKKILAE 476

                         490       500
                  ....*....|....*....|....*.
gi 1108551342 490 FEPPPLDIAIRDELADFVARRKAEGG 515
Cdd:pfam06253 477 YEAPPLDPAIDEALRDFIARRKAEGG 502
 
Name Accession Description Interval E-value
MTTB pfam06253
Trimethylamine methyltransferase (MTTB); This family consists of several trimethylamine ...
 11-515 0e+00

Trimethylamine methyltransferase (MTTB); This family consists of several trimethylamine methyltransferase (MTTB) (EC:2.1.1.-) proteins from numerous Rhizobium and Methanosarcina species.


Pssm-ID: 428852  Cd Length: 502  Bit Score: 788.39  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108551342  11 RSGGRAGAKTRRGSAVIEQMpWNPPVNLDRPTEPLTEEGVLAIHDGAMRILEEIGIEFLNPEAAGILARAGCTVDGDNVR 90
Cdd:pfam06253   1 RRGGRAARRARRAAPRADQS-WPYIVRGIPPYEPLSEEGIAAIEEAAMRILEEIGIEFRDPEALELWRAAGADVDGERVR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108551342  91 MGRDMVMEWVGKAPSEFTLTPRNPDRRITVGGRNLLFGNVSSPPNYWDMGIGRKvPGTREMCRDLLRLTQYFNCIHFAGG 170
Cdd:pfam06253  80 FDRGLVRELLATAPRQFTLHARNPERDVVIGGNNLVFAPVYGPPFVRDLDRGRR-YGTLADFRNFVKLTQMFPWLHHSGG 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108551342 171 YPVEPVDVHASVRHLDVLYDKLTLTDKVMHAYSLGKERVEDVMEMVRISQGLTHDEFDAKPRMYTNINSTSPLKHDHPMM 250
Cdd:pfam06253 159 TVVEPVDVPVNKRHLDMLYAHLTLSDKPFMGSVTGPERAEDSIEMCRILFGLSFAEFRANPVMTTNINVNSPLTFDETML 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108551342 251 DGWMRLARRGQGLVVTPFTLAGAMAPVTMAGAVAQSLAEALCAVVLAQIIRPGCPVAIGTFTSNVDMKSGAPAFGTPEYM 330
Cdd:pfam06253 239 GGLRVYARAGQAVIVTPFILAGAMAPVTVAGALAQSLAEALAGIALTQLVRPGAPVIYGTFTSNVDMKSGAPTFGTPEPA 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108551342 331 RATQMTGQMARFYGLPLRSSGV-CAANVPDGQAMWETSNSLWAAVQSGTNMVYHAAGWLEGGLIASPEKFIMDCEVLQQI 409
Cdd:pfam06253 319 LATYVAGQLARRYGLPWRSSGGlTASKIPDAQAAYESAMSLWAALLAGANFVLHAAGWLEGGLTASYEKFVMDADMLGMI 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108551342 410 QRYMQPeiCATGPDEIALDAIKAVGNAGHFFGIQHTQDRYTTAFYQPFLSDWKNYEGWEAAGSVWTPERAHHMFKEIVTS 489
Cdd:pfam06253 399 HRLLAG--IDVSDDALAMDAIREVGPGGHFLGCAHTQARYETAFYRPELSDWRNFETWEEEGAKDTAERANRRWKKILAE 476

                         490       500
                  ....*....|....*....|....*.
gi 1108551342 490 FEPPPLDIAIRDELADFVARRKAEGG 515
Cdd:pfam06253 477 YEAPPLDPAIDEALRDFIARRKAEGG 502
MttB2 COG5598
Trimethylamine:corrinoid methyltransferase [Coenzyme transport and metabolism];
41-510 0e+00

Trimethylamine:corrinoid methyltransferase [Coenzyme transport and metabolism];


Pssm-ID: 444334  Cd Length: 469  Bit Score: 676.88  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108551342  41 PTEPLTEEGVLAIHDGAMRILEEIGIEFLNPEAAGILARAGCTVDGDNVRMGRDMVMEWVGKAPSEFTLTPRNPDRRITV 120
Cdd:COG5598     2 RYEPLSEEQIERIHEAALRILEEIGVEFEHEEALEIFKKAGARVEGGRVRIPRALVEEALATAPSSFTLYARNPERDVEL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108551342 121 GGRNLLFGNVSSPPNYWDMGIGRKVPGTREMCRDLLRLTQYFNCIHFAGGYPVEPVDVHASVRHLDVLYDKLTLTDKVMH 200
Cdd:COG5598    82 GGGNVVFGPGGGAPFVLDLETGERRPATLEDLANFAKLADALPNIDFSGGNPVEPSDVPVEVRHLDMLYAMLKYTDKPIM 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108551342 201 AYSLGKERVEDVMEMVRISQGlTHDEFDAKPRMYTNINSTSPLKHDHPMMDGWMRLARRGQGLVVTPFTLAGAMAPVTMA 280
Cdd:COG5598   162 GSATGRERVEDSIEMARIVAG-GEEELREKPVVITLINPNSPLRFDEEMLEALIAYARAGQPVIITPFGLAGATAPVTLA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108551342 281 GAVAQSLAEALCAVVLAQIIRPGCPVAIGTFTSNVDMKSGAPAFGTPEYMRATQMTGQMARFYGLPLRSS-GVCAANVPD 359
Cdd:COG5598   241 GALAQQNAEALAGLVLAQLIRPGAPVIYGTFSSSMDMRTGAPAFGTPEAALLSAAAAQLARYYGLPSRSGgGLTDSKLPD 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108551342 360 GQAMWETSNSLWAAVQSGTNMVYHAAGWLEGGLIASPEKFIMDCEVLQQIQRYMQPeIcATGPDEIALDAIKAVGNAGHF 439
Cdd:COG5598   321 AQAGYESAMSLLAAALAGANLILHAAGWLESGLTASYEKFVLDNEIIGMVRRLLRG-I-EVDEETLALDAIKEVGPGGHF 398

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1108551342 440 FGIQHTQDRYTTAFYQPFLSDWKNYEGWEAAGSVWTPERAHHMFKEIVTSFEPPPLDIAIRDELADFVARR 510
Cdd:COG5598   399 LGHPHTLKHYRTEFYYPKLSDRENYEQWEEAGSKDLLERANEKVKEILAEYEPPPLDPEIDEELDAYIARR 469
 
Name Accession Description Interval E-value
MTTB pfam06253
Trimethylamine methyltransferase (MTTB); This family consists of several trimethylamine ...
 11-515 0e+00

Trimethylamine methyltransferase (MTTB); This family consists of several trimethylamine methyltransferase (MTTB) (EC:2.1.1.-) proteins from numerous Rhizobium and Methanosarcina species.


Pssm-ID: 428852  Cd Length: 502  Bit Score: 788.39  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108551342  11 RSGGRAGAKTRRGSAVIEQMpWNPPVNLDRPTEPLTEEGVLAIHDGAMRILEEIGIEFLNPEAAGILARAGCTVDGDNVR 90
Cdd:pfam06253   1 RRGGRAARRARRAAPRADQS-WPYIVRGIPPYEPLSEEGIAAIEEAAMRILEEIGIEFRDPEALELWRAAGADVDGERVR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108551342  91 MGRDMVMEWVGKAPSEFTLTPRNPDRRITVGGRNLLFGNVSSPPNYWDMGIGRKvPGTREMCRDLLRLTQYFNCIHFAGG 170
Cdd:pfam06253  80 FDRGLVRELLATAPRQFTLHARNPERDVVIGGNNLVFAPVYGPPFVRDLDRGRR-YGTLADFRNFVKLTQMFPWLHHSGG 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108551342 171 YPVEPVDVHASVRHLDVLYDKLTLTDKVMHAYSLGKERVEDVMEMVRISQGLTHDEFDAKPRMYTNINSTSPLKHDHPMM 250
Cdd:pfam06253 159 TVVEPVDVPVNKRHLDMLYAHLTLSDKPFMGSVTGPERAEDSIEMCRILFGLSFAEFRANPVMTTNINVNSPLTFDETML 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108551342 251 DGWMRLARRGQGLVVTPFTLAGAMAPVTMAGAVAQSLAEALCAVVLAQIIRPGCPVAIGTFTSNVDMKSGAPAFGTPEYM 330
Cdd:pfam06253 239 GGLRVYARAGQAVIVTPFILAGAMAPVTVAGALAQSLAEALAGIALTQLVRPGAPVIYGTFTSNVDMKSGAPTFGTPEPA 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108551342 331 RATQMTGQMARFYGLPLRSSGV-CAANVPDGQAMWETSNSLWAAVQSGTNMVYHAAGWLEGGLIASPEKFIMDCEVLQQI 409
Cdd:pfam06253 319 LATYVAGQLARRYGLPWRSSGGlTASKIPDAQAAYESAMSLWAALLAGANFVLHAAGWLEGGLTASYEKFVMDADMLGMI 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108551342 410 QRYMQPeiCATGPDEIALDAIKAVGNAGHFFGIQHTQDRYTTAFYQPFLSDWKNYEGWEAAGSVWTPERAHHMFKEIVTS 489
Cdd:pfam06253 399 HRLLAG--IDVSDDALAMDAIREVGPGGHFLGCAHTQARYETAFYRPELSDWRNFETWEEEGAKDTAERANRRWKKILAE 476

                         490       500
                  ....*....|....*....|....*.
gi 1108551342 490 FEPPPLDIAIRDELADFVARRKAEGG 515
Cdd:pfam06253 477 YEAPPLDPAIDEALRDFIARRKAEGG 502
MttB2 COG5598
Trimethylamine:corrinoid methyltransferase [Coenzyme transport and metabolism];
41-510 0e+00

Trimethylamine:corrinoid methyltransferase [Coenzyme transport and metabolism];


Pssm-ID: 444334  Cd Length: 469  Bit Score: 676.88  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108551342  41 PTEPLTEEGVLAIHDGAMRILEEIGIEFLNPEAAGILARAGCTVDGDNVRMGRDMVMEWVGKAPSEFTLTPRNPDRRITV 120
Cdd:COG5598     2 RYEPLSEEQIERIHEAALRILEEIGVEFEHEEALEIFKKAGARVEGGRVRIPRALVEEALATAPSSFTLYARNPERDVEL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108551342 121 GGRNLLFGNVSSPPNYWDMGIGRKVPGTREMCRDLLRLTQYFNCIHFAGGYPVEPVDVHASVRHLDVLYDKLTLTDKVMH 200
Cdd:COG5598    82 GGGNVVFGPGGGAPFVLDLETGERRPATLEDLANFAKLADALPNIDFSGGNPVEPSDVPVEVRHLDMLYAMLKYTDKPIM 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108551342 201 AYSLGKERVEDVMEMVRISQGlTHDEFDAKPRMYTNINSTSPLKHDHPMMDGWMRLARRGQGLVVTPFTLAGAMAPVTMA 280
Cdd:COG5598   162 GSATGRERVEDSIEMARIVAG-GEEELREKPVVITLINPNSPLRFDEEMLEALIAYARAGQPVIITPFGLAGATAPVTLA 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108551342 281 GAVAQSLAEALCAVVLAQIIRPGCPVAIGTFTSNVDMKSGAPAFGTPEYMRATQMTGQMARFYGLPLRSS-GVCAANVPD 359
Cdd:COG5598   241 GALAQQNAEALAGLVLAQLIRPGAPVIYGTFSSSMDMRTGAPAFGTPEAALLSAAAAQLARYYGLPSRSGgGLTDSKLPD 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108551342 360 GQAMWETSNSLWAAVQSGTNMVYHAAGWLEGGLIASPEKFIMDCEVLQQIQRYMQPeIcATGPDEIALDAIKAVGNAGHF 439
Cdd:COG5598   321 AQAGYESAMSLLAAALAGANLILHAAGWLESGLTASYEKFVLDNEIIGMVRRLLRG-I-EVDEETLALDAIKEVGPGGHF 398

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1108551342 440 FGIQHTQDRYTTAFYQPFLSDWKNYEGWEAAGSVWTPERAHHMFKEIVTSFEPPPLDIAIRDELADFVARR 510
Cdd:COG5598   399 LGHPHTLKHYRTEFYYPKLSDRENYEQWEEAGSKDLLERANEKVKEILAEYEPPPLDPEIDEELDAYIARR 469
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH