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Conserved domains on  [gi|1093000827|gb|AOZ47755|]
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glycerol-3-phosphate ABC transporter permease [Acidipropionibacterium acidipropionici]

Protein Classification

carbohydrate ABC transporter permease( domain architecture ID 11417684)

carbohydrate ABC transporter permease, part of a periplasmic binding protein (PBP)-dependent ABC transporter may be involved in transport of one or more of a variety of mono-, di-, or polysaccharides, such as trehalose/maltose (MalG) and alginate (AlgM); responsible for translocation of the substrate across the membrane

Gene Ontology:  GO:0055085|GO:0008643
PubMed:  19234479|27273632
TCDB:  3.A.1.1.

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
UgpE COG0395
ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and ...
 30-301 4.61e-99

ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and metabolism];


:

Pssm-ID: 440164 [Multi-domain]  Cd Length: 282  Bit Score: 292.38  E-value: 4.61e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093000827  30 WTRRLLGGYLPLIAACLLIVAPLLWMVLGSFKTSGEVVTQDLVLWPHHPSFDAYTSASSKVNFPRLFANSVLVTAVGAFI 109
Cdd:COG0395    10 RRLGRILLYLLLILLALLFLFPLYWMVVTSFKPPAEIFSGPPSLLPSEFTLENYRAAFTDGPFGRYLLNSLIVAVVSTVL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093000827 110 KLVLAITSGYAFSFLRFPGRRIIFTLILVALMVPSQVSMVPNYITIAGLGGVNTYWGIILPGL--GTAFGTFLLRQSFMA 187
Cdd:COG0395    90 SLLLSSLAAYALARFRFRGRKLLFLLILATLMIPGQVLLIPLYLLFRQLGLLNTYWGLILPYLafGLPFGIFLLRQFFRS 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093000827 188 LPIDVLEAAEIDGAGHLGRLSRMVVPMAAPAIATVALITIVDEWNNYIWPLVITTDDSRMTLPVGLTLLKNIEGdpSAYP 267
Cdd:COG0395   170 IPRELEEAARIDGASEFRIFWRIVLPLSKPALATVAIFTFIGAWNDFLWPLILLTSPDLRTLPVGLASFQGQYG--TDWG 247

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1093000827 268 VLMAGAVVVIAPVLLIFLFLQRHIVAGLTQGAVK 301
Cdd:COG0395   248 LLMAAAVIATLPVLILFLFLQRYFVRGLTAGAVK 281
 
Name Accession Description Interval E-value
UgpE COG0395
ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and ...
 30-301 4.61e-99

ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440164 [Multi-domain]  Cd Length: 282  Bit Score: 292.38  E-value: 4.61e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093000827  30 WTRRLLGGYLPLIAACLLIVAPLLWMVLGSFKTSGEVVTQDLVLWPHHPSFDAYTSASSKVNFPRLFANSVLVTAVGAFI 109
Cdd:COG0395    10 RRLGRILLYLLLILLALLFLFPLYWMVVTSFKPPAEIFSGPPSLLPSEFTLENYRAAFTDGPFGRYLLNSLIVAVVSTVL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093000827 110 KLVLAITSGYAFSFLRFPGRRIIFTLILVALMVPSQVSMVPNYITIAGLGGVNTYWGIILPGL--GTAFGTFLLRQSFMA 187
Cdd:COG0395    90 SLLLSSLAAYALARFRFRGRKLLFLLILATLMIPGQVLLIPLYLLFRQLGLLNTYWGLILPYLafGLPFGIFLLRQFFRS 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093000827 188 LPIDVLEAAEIDGAGHLGRLSRMVVPMAAPAIATVALITIVDEWNNYIWPLVITTDDSRMTLPVGLTLLKNIEGdpSAYP 267
Cdd:COG0395   170 IPRELEEAARIDGASEFRIFWRIVLPLSKPALATVAIFTFIGAWNDFLWPLILLTSPDLRTLPVGLASFQGQYG--TDWG 247

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1093000827 268 VLMAGAVVVIAPVLLIFLFLQRHIVAGLTQGAVK 301
Cdd:COG0395   248 LLMAAAVIATLPVLILFLFLQRYFVRGLTAGAVK 281
PRK10973 PRK10973
sn-glycerol-3-phosphate ABC transporter permease UgpE;
41-295 2.18e-37

sn-glycerol-3-phosphate ABC transporter permease UgpE;


Pssm-ID: 182875 [Multi-domain]  Cd Length: 281  Bit Score: 134.09  E-value: 2.18e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093000827  41 LIAACLLIVAPLLWMVLGSFKTSGEVVTQDLVLWPHHPSFDAYT------SASSKVNFPRLFANSVLVTAVGAFIKLVLA 114
Cdd:PRK10973   16 LILGIAVILFPLYVAFVAATLDKQAVFAVPMTLIPGTHLLENIAniwvngVGNNSAPFGRMLLNSFVMAFSITVGKITVS 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093000827 115 ITSGYAFSFLRFPGRRIIFTLILVALMVPSQVSMVPNYITIAGLGGVNTYWGIILPGLGTAFGTFLLRQSFMALPIDVLE 194
Cdd:PRK10973   96 MLSAFAIVWFRFPLRNLFFWMIFITLMLPVEVRIFPTVEVIANLKMLDSYAGLTLPLMASATATFLFRQFFMTLPDELVE 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093000827 195 AAEIDGAGHLGRLSRMVVPMAAPAIATVALITIVDEWNNYIWPLVITTDDSRMTLPVGLTLLKNIEGDPSAYPVLMAGAV 274
Cdd:PRK10973  176 AARIDGASPMRFFWDIVLPLSKTNLAALFVITFIYGWNQYLWPLLIITDVSLGTAVAGIKGMIATGEGTTEWNQVMAAML 255

                         250       260
                  ....*....|....*....|.
gi 1093000827 275 VVIAPVLLIFLFLQRHIVAGL 295
Cdd:PRK10973  256 LTLIPPVVIVLAMQRAFVRGL 276
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 96-281 8.59e-13

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 65.76  E-value: 8.59e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093000827  96 FANSVLVTAVGAFIKLVLAITSGYAFSFLRFPGRRIIFTLILVALMVPSQVSMVPNYITIAGLGGVNTYWGIILPGL--- 172
Cdd:cd06261     1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILPGLGLPALila 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093000827 173 ---GTAFGTFLLRQSFMALPIDVLEAAEIDGAGHLGRLSRMVVPMAAPAIATVALITIVDEWNNYIWPLVITTDDSRMtl 249
Cdd:cd06261    81 lllIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPG-- 158

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1093000827 250 PVGLTLLKNIEGDPSAYPVLMAGAVVVIAPVL 281
Cdd:cd06261   159 PGTGLLLIFAILFPGDLGVAAAVALILLLLSL 190
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 123-297 3.32e-09

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 55.38  E-value: 3.32e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093000827 123 FLRFPGRRIIFTLILVALMVPSQVsMVPNYITIAGLGGVNTYW---GIILPGLGTAFGTFLLRQSFMALPIDVLEAAEID 199
Cdd:pfam00528  11 RRGRRLDRLLRPLIDLLQALPSFV-LAILLVVIAILSILGHGIlpaIILALLGWAGYARLIRRAALRSLPSDLVEAARAL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093000827 200 GAGHLGRLSRMVVPMAAPAIATVALITIVDEWNNYIWPLVITTDDsrmtlPVGLTLLKNIEG-DPSAYPVLMAGAVVVIA 278
Cdd:pfam00528  90 GASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWP-----GLGLLLIEAILGyDYPEIQGPVLAAALILL 164

                         170
                  ....*....|....*....
gi 1093000827 279 PVLLIFLFLQRHIVAGLTQ 297
Cdd:pfam00528 165 LLNLLVDILQRLLDPRVRK 183
 
Name Accession Description Interval E-value
UgpE COG0395
ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and ...
 30-301 4.61e-99

ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440164 [Multi-domain]  Cd Length: 282  Bit Score: 292.38  E-value: 4.61e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093000827  30 WTRRLLGGYLPLIAACLLIVAPLLWMVLGSFKTSGEVVTQDLVLWPHHPSFDAYTSASSKVNFPRLFANSVLVTAVGAFI 109
Cdd:COG0395    10 RRLGRILLYLLLILLALLFLFPLYWMVVTSFKPPAEIFSGPPSLLPSEFTLENYRAAFTDGPFGRYLLNSLIVAVVSTVL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093000827 110 KLVLAITSGYAFSFLRFPGRRIIFTLILVALMVPSQVSMVPNYITIAGLGGVNTYWGIILPGL--GTAFGTFLLRQSFMA 187
Cdd:COG0395    90 SLLLSSLAAYALARFRFRGRKLLFLLILATLMIPGQVLLIPLYLLFRQLGLLNTYWGLILPYLafGLPFGIFLLRQFFRS 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093000827 188 LPIDVLEAAEIDGAGHLGRLSRMVVPMAAPAIATVALITIVDEWNNYIWPLVITTDDSRMTLPVGLTLLKNIEGdpSAYP 267
Cdd:COG0395   170 IPRELEEAARIDGASEFRIFWRIVLPLSKPALATVAIFTFIGAWNDFLWPLILLTSPDLRTLPVGLASFQGQYG--TDWG 247

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1093000827 268 VLMAGAVVVIAPVLLIFLFLQRHIVAGLTQGAVK 301
Cdd:COG0395   248 LLMAAAVIATLPVLILFLFLQRYFVRGLTAGAVK 281
MalG COG3833
ABC-type maltose transport system, permease component MalG [Carbohydrate transport and ...
 30-301 4.92e-68

ABC-type maltose transport system, permease component MalG [Carbohydrate transport and metabolism];


Pssm-ID: 443045 [Multi-domain]  Cd Length: 282  Bit Score: 213.09  E-value: 4.92e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093000827  30 WTRRLLGGYLPLIAACLLIVAPLLWMVLGSFKTSGEVVTQDLvlWPHHPSFDAYTSASSKVNFPRLFANSVLVTAVGAFI 109
Cdd:COG3833    11 RRLKLGLRHLVLIILAIIALFPILWVVSASFNPGGSLYSSSL--IPENFTLENYKKLFTETPFLRWFLNSLIVAVVTAII 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093000827 110 KLVLAITSGYAFSFLRFPGRRIIFTLILVALMVPSQVSMVPNYITIAGLGGVNTYWGIILPGLGTA--FGTFLLRQSFMA 187
Cdd:COG3833    89 SVFLAALAAYAFSRFRFKGRKAGLLALLLLQMFPAFLALVALYLLLSALGLLNTLLGLILVYLGGAipFNTWLMKGYFDT 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093000827 188 LPIDVLEAAEIDGAGHLGRLSRMVVPMAAPAIATVALITIVDEWNNYIWPLVITTDDSRMTLPVGLTLLknIEGDPSA-Y 266
Cdd:COG3833   169 IPKELDEAAKIDGASHFQIFFRIILPLAKPILAVVALLSFIGPWNDFILASVLLRSPENYTLAVGLYSF--VSDQRNTnW 246

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1093000827 267 PVLMAGAVVVIAPVLLIFLFLQRHIVAGLTQGAVK 301
Cdd:COG3833   247 GVFAAGAVLVAIPIVILFLFLQRYLVSGLTAGGVK 281
PRK10973 PRK10973
sn-glycerol-3-phosphate ABC transporter permease UgpE;
41-295 2.18e-37

sn-glycerol-3-phosphate ABC transporter permease UgpE;


Pssm-ID: 182875 [Multi-domain]  Cd Length: 281  Bit Score: 134.09  E-value: 2.18e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093000827  41 LIAACLLIVAPLLWMVLGSFKTSGEVVTQDLVLWPHHPSFDAYT------SASSKVNFPRLFANSVLVTAVGAFIKLVLA 114
Cdd:PRK10973   16 LILGIAVILFPLYVAFVAATLDKQAVFAVPMTLIPGTHLLENIAniwvngVGNNSAPFGRMLLNSFVMAFSITVGKITVS 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093000827 115 ITSGYAFSFLRFPGRRIIFTLILVALMVPSQVSMVPNYITIAGLGGVNTYWGIILPGLGTAFGTFLLRQSFMALPIDVLE 194
Cdd:PRK10973   96 MLSAFAIVWFRFPLRNLFFWMIFITLMLPVEVRIFPTVEVIANLKMLDSYAGLTLPLMASATATFLFRQFFMTLPDELVE 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093000827 195 AAEIDGAGHLGRLSRMVVPMAAPAIATVALITIVDEWNNYIWPLVITTDDSRMTLPVGLTLLKNIEGDPSAYPVLMAGAV 274
Cdd:PRK10973  176 AARIDGASPMRFFWDIVLPLSKTNLAALFVITFIYGWNQYLWPLLIITDVSLGTAVAGIKGMIATGEGTTEWNQVMAAML 255

                         250       260
                  ....*....|....*....|.
gi 1093000827 275 VVIAPVLLIFLFLQRHIVAGL 295
Cdd:PRK10973  256 LTLIPPVVIVLAMQRAFVRGL 276
malG PRK10998
maltose ABC transporter permease MalG;
23-301 7.45e-23

maltose ABC transporter permease MalG;


Pssm-ID: 182891  Cd Length: 296  Bit Score: 95.55  E-value: 7.45e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093000827  23 SIVGPDPWTRRLLGGYLPLIAACLLIVAPLLWMVLGSFkTSGEVVTQDLvlWPHHPSFD--------AYTSASSKVN--- 91
Cdd:PRK10998    2 AMVQPKSQKLRLFATHLLLLGFIALIMFPLLMVIAISL-REGNFATGSL--IPEQISWEhwklalgfSVEHADGRVTppp 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093000827  92 FPRL--FANSVLVTAVGAFIKLVLAITSGYAFSFLRFPGRRIIFTLILVALMVPSQVSMVPNYITIAGLG------GVNT 163
Cdd:PRK10998   79 FPVLlwLWNSVKVAGITAIGIVALSTTCAYAFARMRFKGKATLLKGMLIFQMFPAVLSLVALYALFDRLGqyipfiGLNT 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093000827 164 YWGIILPGL-GTAFGTFLLRQSFMALPIDVLEAAEIDGAGHLGRLSRMVVPMAAPAIATVALITIVDEWNNYIWPLVITT 242
Cdd:PRK10998  159 HGGVIFAYLgGIALHVWTIKGYFETIDSSLEEAAALDGATPWQAFRLVLLPLSVPILAVVFILSFIAAITEVPVASLLLR 238

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1093000827 243 DDSRMTLPVGLTLLKNIE----GDPSAYPVLMAgavvviAPVLLIFLFLQRHIVAGLTQGAVK 301
Cdd:PRK10998  239 DVNSYTLAVGMQQYLNPQnylwGDFAAAAVLSA------IPITVVFLLAQRWLVGGLTAGGVK 295
PotC COG1177
ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport ...
 30-289 6.78e-21

ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism];


Pssm-ID: 440790 [Multi-domain]  Cd Length: 262  Bit Score: 89.40  E-value: 6.78e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093000827  30 WTRRLLGGYLplIAACLLIVAPLLWMVLGSFKTSgevvtQDLVLWPHHPSFDAYTSASSKVNFPRLFANSVLVTAVGAFI 109
Cdd:COG1177     4 LGRLLLRLFL--ALVLLFLYLPILVLVLYSFNDS-----WFLTFPPEGFTLRWYAELFSDPRLLDALLNSLLIALLSTLL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093000827 110 KLVLAITSGYAFSFLRFPGRRIIFTLILVALMVPSQVSMVPNYITIAGLGGVNTYWGIILP--GLGTAFGTFLLRQSFMA 187
Cdd:COG1177    77 ATVLGTPAALALARYRFRGRRLLLALLLLPLVVPGIVLGVALLLLFSALGLSGGLWGLILAhvVFTLPFVVLVVLARLQG 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093000827 188 LPIDVLEAAEIDGAGHLGRLSRMVVPMAAPAIATVALITIVDEWNNYIWPLVITTDDSRmTLPVGL-TLLKNiegdpSAY 266
Cdd:COG1177   157 FDPSLEEAARDLGASPWQTFRRVTLPLIAPGILAGALLAFTLSFDEFVITLFLAGPGVT-TLPVYIySMIRR-----GIS 230

                         250       260
                  ....*....|....*....|...
gi 1093000827 267 PVLMAGAVVVIAPVLLIFLFLQR 289
Cdd:COG1177   231 PEINALSTLLILLSLLLLLLAER 253
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
32-289 1.21e-14

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 74.04  E-value: 1.21e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093000827  32 RRLLGGYLPLIAACLLIVAPLLWMVLGSFktsgevvtqdlvlwphHPSFDAYTSASSKVNFPRLFANSVLVTAVGAFIKL 111
Cdd:COG1178     8 RPRLLLLLLALLLALLVLLPLLALLLRAF----------------TDGLANFWALLSDPYLWRALGNTLLLALLVTLLSL 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093000827 112 VLAITSGYAFSFLRFPGRRIIFTLILVALMVPSQV-SMVpnYITIAGLGGVNTYW-----GIILPGLGTAFG-------- 177
Cdd:COG1178    72 LLGVPLAWLLARTDFPGRRLLRWLLLLPLALPPYVvALA--WIALFGPNGLLNTLlralfGLEPPDIYGLGGiilvlvlf 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093000827 178 -----TFLLRQSFMALPIDVLEAAEIDGAGHLGRLSRMVVPMAAPAIATVALITIVDEWNNYIWPLVITTDDSrmTLPVG 252
Cdd:COG1178   150 nypyvYLLLRAALRSIDASLEEAARSLGASPWRAFRRVTLPLLRPAIAAGALLVFLLCLADFGTPLVLGGGYT--TLTTA 227

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1093000827 253 LTLLKNIEGDPSAYPVLmagAVVVIAPVLLIFLFLQR 289
Cdd:COG1178   228 IYQAWLGDFDLGAAAAL---ALVLLLLVLLLLLLERR 261
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 96-281 8.59e-13

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 65.76  E-value: 8.59e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093000827  96 FANSVLVTAVGAFIKLVLAITSGYAFSFLRFPGRRIIFTLILVALMVPSQVSMVPNYITIAGLGGVNTYWGIILPGL--- 172
Cdd:cd06261     1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILPGLGLPALila 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093000827 173 ---GTAFGTFLLRQSFMALPIDVLEAAEIDGAGHLGRLSRMVVPMAAPAIATVALITIVDEWNNYIWPLVITTDDSRMtl 249
Cdd:cd06261    81 lllIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPG-- 158

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1093000827 250 PVGLTLLKNIEGDPSAYPVLMAGAVVVIAPVL 281
Cdd:cd06261   159 PGTGLLLIFAILFPGDLGVAAAVALILLLLSL 190
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
32-229 1.41e-10

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 61.72  E-value: 1.41e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093000827  32 RRLLGGYLPLIAACLLIVAPLLWMVLGSFKTsgevvtqdlvLWPHHPSFDAYTSASSKVNFPRLFANSVLVTAVGAFIKL 111
Cdd:COG1178   286 WRWLALALCLLLVLLGLLLPLLALLLWSLTK----------ALDDNLTLDNYRFVLLDPSLLRALLNSLLLALLAALLAV 355

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093000827 112 VLAITSGYAFSFLRFPGRRIIFTLILVALMVPSQV---SMVPNYITIAGLGGVNTYWGIILPGLG--TAFGTFLLRQSFM 186
Cdd:COG1178   356 LLALLLAYLVRRRRGRLARLLDRLAMLPYAVPGIVlglGLLLLFNRPLPLLLYGTLAILVLAYVVrfLPFALRSLEAALA 435

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1093000827 187 ALPIDVLEAAEIDGAGHLGRLSRMVVPMAAPAIATVALITIVD 229
Cdd:COG1178   436 QIDPSLEEAARSLGASPLRTLRRVTLPLLRPGLLAAALLVFVT 478
UgpA COG1175
ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];
23-241 3.27e-09

ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440788 [Multi-domain]  Cd Length: 298  Bit Score: 56.68  E-value: 3.27e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093000827  23 SIVGPDPWTRRLLGGYL----PLIAACLLIVAPLLWMVLGSFktsgevvtQDLVLWPHHPSF---DAYTSASSKVNFPRL 95
Cdd:COG1175     6 SAAARRRRRRRRLAAYLfllpALLLLLVFVLYPLLYTLYLSF--------TDWNLLGPPPEFvglDNYARLFTDPRFWNA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093000827  96 FANSVLVTAVGAFIKLVLAItsgyAFSFL---RFPGRRIIFTLILVALMVPS-------------QVSMVPNYITIAGLG 159
Cdd:COG1175    78 LGNTLLFTVVSVPLQLVLGL----LLALLlnrKLRGRGFFRTLFFLPWVISPvvvaliwkwlfnpDYGLLNALLGALGLE 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093000827 160 GVN-------TYWGIILPGL--GTAFGTFLLRQSFMALPIDVLEAAEIDGAGHLGRLSRMVVPMAAPAIATVALITIVDE 230
Cdd:COG1175   154 PINwlgdpslALPAVIIVTVwkGTGFNMLIFLAGLQSIPRELYEAARIDGASPWQRFRRITLPLLRPTILFVLVLSTIGA 233

                         250
                  ....*....|.
gi 1093000827 231 WNNYIWPLVIT 241
Cdd:COG1175   234 LQVFDLVYVLT 244
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 123-297 3.32e-09

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 55.38  E-value: 3.32e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093000827 123 FLRFPGRRIIFTLILVALMVPSQVsMVPNYITIAGLGGVNTYW---GIILPGLGTAFGTFLLRQSFMALPIDVLEAAEID 199
Cdd:pfam00528  11 RRGRRLDRLLRPLIDLLQALPSFV-LAILLVVIAILSILGHGIlpaIILALLGWAGYARLIRRAALRSLPSDLVEAARAL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093000827 200 GAGHLGRLSRMVVPMAAPAIATVALITIVDEWNNYIWPLVITTDDsrmtlPVGLTLLKNIEG-DPSAYPVLMAGAVVVIA 278
Cdd:pfam00528  90 GASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWP-----GLGLLLIEAILGyDYPEIQGPVLAAALILL 164

                         170
                  ....*....|....*....
gi 1093000827 279 PVLLIFLFLQRHIVAGLTQ 297
Cdd:pfam00528 165 LLNLLVDILQRLLDPRVRK 183
PotB COG1176
ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport ...
 32-228 8.09e-08

ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism];


Pssm-ID: 440789 [Multi-domain]  Cd Length: 287  Bit Score: 52.46  E-value: 8.09e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093000827  32 RRLLGGYL----PLIAACLLIVAPLLWMVLGSFKTSGEVVTQDLVLwphhpSFDAYTSASSKVNFPRLFANSVLVTAVGA 107
Cdd:COG1176     6 RRRLRPLLlllpALLWLLLFFVLPLLLLLVYSFTTRDPYGGVVPGF-----TLENYARLFTDPLYLKVLLRTLWIALLTT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093000827 108 FIKLVLAITSGYAFSFLRFPGRRIIFTLILVALMVPSqvsMVPNY--ITIAGLGGV------------------NTYWGI 167
Cdd:COG1176    81 LICLLLGYPIAYFLARAPPRWRNLLLLLVILPFWTSF---LVRTYawIVLLGRNGLlnslllalglideplrllYTEFAV 157

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1093000827 168 ILpGL---GTAFGTFLLRQSFMALPIDVLEAAEIDGAGHLGRLSRMVVPMAAPAIATVALITIV 228
Cdd:COG1176   158 VI-GLvyvYLPFMVLPLYAALEKIDPSLLEAARDLGASPWQTFRRVILPLSLPGIIAGSLLVFI 220
CysU COG0555
ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism]; ...
 29-226 8.41e-08

ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440321 [Multi-domain]  Cd Length: 268  Bit Score: 52.44  E-value: 8.41e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093000827  29 PWTRRLLGgyLPLIAACLLIVAPLLWMVLGSFKTS----GEVVTQDLVLwphhpsfdaytsASSKVnfprlfanSVLVTA 104
Cdd:COG0555     7 PGFGLTLG--LTLLYLSLIVLLPLAALVLKAAGLGwaefWAVLTSPRVL------------AALKL--------SLGTAL 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093000827 105 VGAFIKLVLAITSGYAFSFLRFPGRRIIFTLILVALMVPSQVS------------MVPNYITIAGLGGVNTYWGIILPGL 172
Cdd:COG0555    65 IAALINLVFGLPLAWVLVRYRFPGKRLVDALVDLPFALPTAVAgiallllfgpngWLGQLLAPLGIKVAFTPLGIVLAQT 144

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1093000827 173 GTAFgTFLLRQ---SFMALPIDVLEAAEIDGAGHLGRLSRMVVPMAAPAIATVALIT 226
Cdd:COG0555   145 FVSL-PFVVRTvqpVLEELDPELEEAAATLGASRWQTFRRVILPLLLPALLTGFALA 200
PRK15050 PRK15050
2-aminoethylphosphonate transport system permease PhnU; Provisional
 8-299 1.67e-03

2-aminoethylphosphonate transport system permease PhnU; Provisional


Pssm-ID: 237888 [Multi-domain]  Cd Length: 296  Bit Score: 39.22  E-value: 1.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093000827   8 TRVRIPKAAGAPADEsivgPDPWtRRLLGGYLPLIAACLLIVAPLLWMVLGSFKTsgevvtqdlvlwPHHPSFDAYTSAS 87
Cdd:PRK15050    4 RVRASAAAHAAAARR----RRRL-RPLLWLLLPLLVLAPLVVYPLVRVVLQSLTG------------EHGLGLATYRAVL 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093000827  88 SKVNFPRLFANSVLVTAVGAFIKLVLAITSGYAFSFLRFPGRRIIFTLILVALMVPS---------------QVSMVPNY 152
Cdd:PRK15050   67 GSPDFRGALLTTLQIAFASTAGCLVLGVLLALVLAFVPFPGASLVGRFIDTFVAFPSflitlaftflygsagSVNIALQR 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093000827 153 ITIAGLGGVN---TYWGIILPGLgTAFGTFLLR---QSFMALPIDVLEAAEIDGAGHLGRLSRMVVPMAAPAIATVALIT 226
Cdd:PRK15050  147 LFGLEAPPLDflySPGGVILAEI-TFYTPFVVRpllAAFAQLDARQLEAAASLGASPWRVARRVILPEAWPALAAGGSLC 225

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1093000827 227 IVDEWNNYIWPLVITTDDSrMTLPVGLTLLKNIEGDpsaYPVLMAGAVVVIAPVLLIFLfLQRHIVAGLTQGA 299
Cdd:PRK15050  226 LLLTLNEFGIVLFTGAKDV-VTLPVLIYSKAIVDFD---YPTACAIAVVNLALSLGLYA-LYRRVNRRAGGGS 293
potC PRK09500
spermidine/putrescine ABC transporter membrane protein; Reviewed
 32-220 1.92e-03

spermidine/putrescine ABC transporter membrane protein; Reviewed


Pssm-ID: 236542 [Multi-domain]  Cd Length: 256  Bit Score: 39.20  E-value: 1.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093000827  32 RRLLGGYLPLIAACLLIvaPLLWMVLGSFKTSGEVVTqdlvlWPHHpSFDAYTSASSKVNFPRLFANSVLVTAVGAFIKL 111
Cdd:PRK09500    3 RLLRGGFMTLVYAYLYI--PIIILIVNSFNSSRFGIN-----WKGF-TTKWYELLFNNDSLLQAAQHSLTMAVFSATFAT 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093000827 112 VLAITSGYAFSFLRFPGRRIIFTLILVALMVPSQVSMVPNYITIAGLGGVNTYWGIILP--GLGTAFGTFLLRQSFMALP 189
Cdd:PRK09500   75 LIGSLTAVALYRYRFRGKKFVSGMLFVVMMSPDIVMAISLLVLFMLLGIQLGFWSLLFAhiTFCLPFVVVTVYSRLKGFD 154

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1093000827 190 IDVLEAAEIDGAGHLGRLSRMVVPMAAPAIA 220
Cdd:PRK09500  155 VRMLEAAKDLGASEFTILRKIILPLALPAVA 185
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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