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Conserved domains on  [gi|1078672751|gb|AOW19857|]
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acyltransferase [Urechidicola croceus]

Protein Classification

lysophospholipid acyltransferase family protein( domain architecture ID 106732)

lysophospholipid acyltransferase (LPLAT) family protein may act as an acyltransferase of a de novo or remodeling pathway of glycerophospholipid biosynthesis, catalyzing the incorporation of an acyl group from either acyl-CoAs or acyl-acyl carrier proteins (acyl-ACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LPLAT super family cl17185
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 9-169 1.70e-71

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


The actual alignment was detected with superfamily member cd07988:

Pssm-ID: 473073 [Multi-domain]  Cd Length: 163  Bit Score: 213.23  E-value: 1.70e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078672751   9 LFKILRWKIDGEFPkDLNKFVIIVVPHTSWVDFPIGVLINFATGINGNYIGKASLFKPPFGFIFRWLGGTPVDRTKSNNL 88
Cdd:cd07988     4 LLRLSGWRIEGEPP-NKPKFVVIGAPHTSNWDFVLGLLAAFALGLKISFLGKHSLFKPPLGPFMRWLGGIPVDRSRAGGL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078672751  89 VNAIVAIFNSNERFILGMSPEGTRKKVSKWKTGFYYVAKGANVPIVSVAFDFEHKTAIIHKPFYTTDDKEADFKILKSNF 168
Cdd:cd07988    83 VEQVVEEFRRREEFVLAIAPEGTRSKVDKWKTGFYHIARGAGVPILLVYLDYKRKTVGIGPLFEPSGDIEADLAAIRAFY 162


                  .
gi 1078672751 169 E 169
Cdd:cd07988   163 R 163
 
Name Accession Description Interval E-value
LPLAT_ABO13168-like cd07988
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 9-169 1.70e-71

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized phospholipid/glycerol acyltransferases such as the Acinetobacter baumannii ATCC 17978 locus ABO13168 putative acyltransferase, and similar proteins.


Pssm-ID: 153250 [Multi-domain]  Cd Length: 163  Bit Score: 213.23  E-value: 1.70e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078672751   9 LFKILRWKIDGEFPkDLNKFVIIVVPHTSWVDFPIGVLINFATGINGNYIGKASLFKPPFGFIFRWLGGTPVDRTKSNNL 88
Cdd:cd07988     4 LLRLSGWRIEGEPP-NKPKFVVIGAPHTSNWDFVLGLLAAFALGLKISFLGKHSLFKPPLGPFMRWLGGIPVDRSRAGGL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078672751  89 VNAIVAIFNSNERFILGMSPEGTRKKVSKWKTGFYYVAKGANVPIVSVAFDFEHKTAIIHKPFYTTDDKEADFKILKSNF 168
Cdd:cd07988    83 VEQVVEEFRRREEFVLAIAPEGTRSKVDKWKTGFYHIARGAGVPILLVYLDYKRKTVGIGPLFEPSGDIEADLAAIRAFY 162


                  .
gi 1078672751 169 E 169
Cdd:cd07988   163 R 163
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 1-164 1.51e-30

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 110.48  E-value: 1.51e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078672751   1 MKTISKFILFKI-LRWKIDGEFPKDLNKFVIIVVPHTSWVDFpigVLINFATGINGNYIGKASLFKPPF-GFIFRWLGGT 78
Cdd:COG0204    16 VRLWARLLLRLLgVRVRVEGLENLPADGPVLIVANHQSWLDI---LLLLAALPRPVRFVAKKELFKIPLlGWLLRALGAI 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078672751  79 PVDRTKSNNLVNAIVAIFNS-NERFILGMSPEGTRK---KVSKWKTGFYYVAKGANVPIVSVAFDFEHK----------- 143
Cdd:COG0204    93 PVDRSKRRAALRALRQAVEAlKAGESLVIFPEGTRSpdgRLLPFKTGAARLALEAGVPIVPVAIDGTERalpkgflprpg 172

                         170       180
                  ....*....|....*....|...
gi 1078672751 144 --TAIIHKPFYTTDDKEADFKIL 164
Cdd:COG0204   173 kvTVRIGPPIDPSDLEGEDRREL 195
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 29-140 3.05e-21

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 83.56  E-value: 3.05e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078672751   29 VIIVVPHTSWVDFPIGVLINFATGINGNYIGKASLFK-PPFGFIFRWLGGTPVDRTKSNNLVNAIVAIFNS-NERFILGM 106
Cdd:smart00563   1 ALVVANHQSFLDPLVLSALLPRKLGRVRFVAKKELFYvPLLGWLLRLLGAIFIDRSNGRKARAALREAVELlKEGEWLLI 80

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1078672751  107 SPEGTR---KKVSKWKTGFYYVAKGANVPIVSVAFDF 140
Cdd:smart00563  81 FPEGTRsrpGKLLPFKKGAARLALEAGVPIVPVAIRG 117
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 30-138 3.42e-12

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 60.37  E-value: 3.42e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078672751  30 IIVVP-HTSWVDFPIGVLINFATGINGNYIGKASLFK-PPFGFIFRWLGGTPVDRT---KSNNLVNAIVAIFNSNErfIL 104
Cdd:pfam01553  16 AIVVAnHQSYLDVLLLSLALYKRGRPLVFVAKKELFDiPLVGWLMRLLGCIFIDRKnrkDAAGTLEYLVELLREGK--LV 93

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1078672751 105 GMSPEGTRK---KVSKWKTGFYYVAKGANVPIVSVAF 138
Cdd:pfam01553  94 VIFPEGTRSregELLPFKKGAFRLAIEAGVPIVPVAI 130
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 29-137 1.02e-09

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 53.89  E-value: 1.02e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078672751  29 VIIVVPHTSWVDFPIgvlINFATGINGNYIGKASLFKPPFGFIFRWLGGT-PVDRTKSNNLVNAIVAIFNSNER-FILGM 106
Cdd:TIGR00530  18 VLVVANHQSNLDPLT---LSAAFPPPIVFIAKKELKWIPFFGIMLWLTGAiFIDRENIRAIATALKAAIEVLKQgRSIGV 94

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1078672751 107 SPEGTRKK---VSKWKTGFYYVAKGANVPIVSVA 137
Cdd:TIGR00530  95 FPEGTRSRgrdILPFKKGAFHIAIKAGVPILPVV 128
PRK15018 PRK15018
1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional
 58-136 1.69e-04

1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional


Pssm-ID: 184979  Cd Length: 245  Bit Score: 40.77  E-value: 1.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078672751  58 IGKASLFKPPFGFIFRWLGGTPV----DRTKSNNLVNAIVAIFNsNERFILGMSPEGTRKK---VSKWKTGFYYVAKGAN 130
Cdd:PRK15018   93 VGKKSLLWIPFFGQLYWLTGNLLidrnNRTKAHGTIAEVVNHFK-KRRISIWMFPEGTRSRgrgLLPFKTGAFHAAIAAG 171


                  ....*.
gi 1078672751 131 VPIVSV 136
Cdd:PRK15018  172 VPIIPV 177
 
Name Accession Description Interval E-value
LPLAT_ABO13168-like cd07988
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 9-169 1.70e-71

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized phospholipid/glycerol acyltransferases such as the Acinetobacter baumannii ATCC 17978 locus ABO13168 putative acyltransferase, and similar proteins.


Pssm-ID: 153250 [Multi-domain]  Cd Length: 163  Bit Score: 213.23  E-value: 1.70e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078672751   9 LFKILRWKIDGEFPkDLNKFVIIVVPHTSWVDFPIGVLINFATGINGNYIGKASLFKPPFGFIFRWLGGTPVDRTKSNNL 88
Cdd:cd07988     4 LLRLSGWRIEGEPP-NKPKFVVIGAPHTSNWDFVLGLLAAFALGLKISFLGKHSLFKPPLGPFMRWLGGIPVDRSRAGGL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078672751  89 VNAIVAIFNSNERFILGMSPEGTRKKVSKWKTGFYYVAKGANVPIVSVAFDFEHKTAIIHKPFYTTDDKEADFKILKSNF 168
Cdd:cd07988    83 VEQVVEEFRRREEFVLAIAPEGTRSKVDKWKTGFYHIARGAGVPILLVYLDYKRKTVGIGPLFEPSGDIEADLAAIRAFY 162


                  .
gi 1078672751 169 E 169
Cdd:cd07988   163 R 163
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 1-164 1.51e-30

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 110.48  E-value: 1.51e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078672751   1 MKTISKFILFKI-LRWKIDGEFPKDLNKFVIIVVPHTSWVDFpigVLINFATGINGNYIGKASLFKPPF-GFIFRWLGGT 78
Cdd:COG0204    16 VRLWARLLLRLLgVRVRVEGLENLPADGPVLIVANHQSWLDI---LLLLAALPRPVRFVAKKELFKIPLlGWLLRALGAI 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078672751  79 PVDRTKSNNLVNAIVAIFNS-NERFILGMSPEGTRK---KVSKWKTGFYYVAKGANVPIVSVAFDFEHK----------- 143
Cdd:COG0204    93 PVDRSKRRAALRALRQAVEAlKAGESLVIFPEGTRSpdgRLLPFKTGAARLALEAGVPIVPVAIDGTERalpkgflprpg 172

                         170       180
                  ....*....|....*....|...
gi 1078672751 144 --TAIIHKPFYTTDDKEADFKIL 164
Cdd:COG0204   173 kvTVRIGPPIDPSDLEGEDRREL 195
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 29-140 3.05e-21

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 83.56  E-value: 3.05e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078672751   29 VIIVVPHTSWVDFPIGVLINFATGINGNYIGKASLFK-PPFGFIFRWLGGTPVDRTKSNNLVNAIVAIFNS-NERFILGM 106
Cdd:smart00563   1 ALVVANHQSFLDPLVLSALLPRKLGRVRFVAKKELFYvPLLGWLLRLLGAIFIDRSNGRKARAALREAVELlKEGEWLLI 80

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1078672751  107 SPEGTR---KKVSKWKTGFYYVAKGANVPIVSVAFDF 140
Cdd:smart00563  81 FPEGTRsrpGKLLPFKKGAARLALEAGVPIVPVAIRG 117
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 5-160 1.46e-18

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 78.47  E-value: 1.46e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078672751   5 SKFILFKI-LRWKIDGEFPKDLNKFVIIVVPHTSWVDfpiGVLINFATGINGNYIGKASLFKPPF-GFIFRWLGGTPVDR 82
Cdd:cd07989     1 LRLLLRLLgVRVRVEGLENLPPKGPVIIVANHQSYLD---PLVLGAALPRPIRFVAKKELFKIPFlGWLLRLLGAIPIDR 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078672751  83 TKSNNLVNAIVAIFNS-NERFILGMSPEGTRKK---VSKWKTGFYYVAKGANVPIVSVAFDFEHK--------------T 144
Cdd:cd07989    78 GNGRSAREALREAIEAlKEGESVVIFPEGTRSRdgeLLPFKSGAFRLAKEAGVPIVPVAISGTWGslpkgkklprpgrvT 157

                         170
                  ....*....|....*.
gi 1078672751 145 AIIHKPFYTTDDKEAD 160
Cdd:cd07989   158 VRIGEPIPPEGLELAE 173
LPLAT cd06551
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 6-141 6.89e-15

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


Pssm-ID: 153244 [Multi-domain]  Cd Length: 187  Bit Score: 68.98  E-value: 6.89e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078672751   6 KFILFKILRWKIDGEFPKDLNKFVIIVVPHTSWVDFPIGVLINFAT-GINGNYIGKASLFkpPFGFIFRWLGGTPVDRTK 84
Cdd:cd06551     5 LLNFFGFVRLEVKGPPPPPGGGPVLFVSNHSSWWDGLILFLLLERGlRRDVYGLMDEELL--ERYPFFTRLGAFSVDRDS 82

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1078672751  85 SNNLV---NAIVAIFnSNERFILGMSPEGTRKKVSK----WKTGFYYVAKGANVPIVSVAFDFE 141
Cdd:cd06551    83 PRSAAkslKYVARLL-SKPGSVVWIFPEGTRTRRDKrplqFKPGVAHLAEKAGVPIVPVALRYT 145
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 30-138 3.42e-12

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 60.37  E-value: 3.42e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078672751  30 IIVVP-HTSWVDFPIGVLINFATGINGNYIGKASLFK-PPFGFIFRWLGGTPVDRT---KSNNLVNAIVAIFNSNErfIL 104
Cdd:pfam01553  16 AIVVAnHQSYLDVLLLSLALYKRGRPLVFVAKKELFDiPLVGWLMRLLGCIFIDRKnrkDAAGTLEYLVELLREGK--LV 93

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1078672751 105 GMSPEGTRK---KVSKWKTGFYYVAKGANVPIVSVAF 138
Cdd:pfam01553  94 VIFPEGTRSregELLPFKKGAFRLAIEAGVPIVPVAI 130
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 29-137 1.02e-09

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 53.89  E-value: 1.02e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078672751  29 VIIVVPHTSWVDFPIgvlINFATGINGNYIGKASLFKPPFGFIFRWLGGT-PVDRTKSNNLVNAIVAIFNSNER-FILGM 106
Cdd:TIGR00530  18 VLVVANHQSNLDPLT---LSAAFPPPIVFIAKKELKWIPFFGIMLWLTGAiFIDRENIRAIATALKAAIEVLKQgRSIGV 94

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1078672751 107 SPEGTRKK---VSKWKTGFYYVAKGANVPIVSVA 137
Cdd:TIGR00530  95 FPEGTRSRgrdILPFKKGAFHIAIKAGVPILPVV 128
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 13-112 5.80e-08

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 50.31  E-value: 5.80e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078672751  13 LRWKIDGEFPKDLNKFVIIVVPHTSWVDFPIGVLINFATGINGN--YIGKASLFKPPFGFIFRWLGG-TPVDRTKSNNLV 89
Cdd:cd07990    10 VKVVVYGDEPKLPKERALIISNHRSEVDWLVLWMLADRFGRLGRlkIVLKDSLKYPPLGGWGWQLGEfIFLKRKWEKDEK 89

                          90       100
                  ....*....|....*....|....*.
gi 1078672751  90 ---NAIVAIFNSNERFILGMSPEGTR 112
Cdd:cd07990    90 tikRQLKRLKDSPEPFWLLIFPEGTR 115
LPLAT_LPCAT1-like cd07991
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; ...
 6-121 5.06e-06

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lysophosphatidylcholine acyltransferase 1 (LPCAT-1), glycerol-3-phosphate acyltransferase 3 (GPAT3), and similar sequences.


Pssm-ID: 153253 [Multi-domain]  Cd Length: 211  Bit Score: 44.90  E-value: 5.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078672751   6 KFILFKILRWKID--GEFPKDlNKFVIIVVPHTSWVDFPIGVLINFATgingnYIGKASLFKPPF-GFIFRWLGGTPVDR 82
Cdd:cd07991     2 RVLLFAFGFYVIKvhGKPDPP-EAPRIIVANHTSFIDPLILFSDLFPS-----IVAKKELGKLPFiGTILRALGCIFVDR 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1078672751  83 TKSN---NLVNAIVAIFNSNERFILGMSPEGT---RKKVSKWKTG 121
Cdd:cd07991    76 SEPKdrkKVVEEIKERATDPNWPPILIFPEGTttnGKALIMFKKG 120
PRK15018 PRK15018
1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional
 58-136 1.69e-04

1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional


Pssm-ID: 184979  Cd Length: 245  Bit Score: 40.77  E-value: 1.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078672751  58 IGKASLFKPPFGFIFRWLGGTPV----DRTKSNNLVNAIVAIFNsNERFILGMSPEGTRKK---VSKWKTGFYYVAKGAN 130
Cdd:PRK15018   93 VGKKSLLWIPFFGQLYWLTGNLLidrnNRTKAHGTIAEVVNHFK-KRRISIWMFPEGTRSRgrgLLPFKTGAFHAAIAAG 171


                  ....*.
gi 1078672751 131 VPIVSV 136
Cdd:PRK15018  172 VPIIPV 177
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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