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Conserved domains on  [gi|1078193711|gb|AOV84561|]
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NADH dehydrogenase subunit 6 (mitochondrion) [Physeter catodon]

Protein Classification

NADH dehydrogenase subunit 6( domain architecture ID 10009569)

NADH dehydrogenase subunit 6 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-174 1.76e-70

NADH dehydrogenase subunit 6; Provisional


:

Pssm-ID: 214421  Cd Length: 175  Bit Score: 210.81  E-value: 1.76e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078193711   1 MMMYFVFVLSIMFVVSFVGVSSKPSPIYGGFGLIVGGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEQYP 80
Cdd:MTH00109    1 MMMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078193711  81 EVWVSNKVVLGGFLLGLVVEFLMMAYVLEGGEVEVVSGFNGLGDWVVCDVGDSGFSGGEAEGVAALYSYGAWLMVVMGWS 160
Cdd:MTH00109   81 ETWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWS 160

                         170
                  ....*....|....
gi 1078193711 161 LFIGVVVIMEITRG 174
Cdd:MTH00109  161 LFIGVFVIIEITRG 174
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-174 1.76e-70

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 210.81  E-value: 1.76e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078193711   1 MMMYFVFVLSIMFVVSFVGVSSKPSPIYGGFGLIVGGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEQYP 80
Cdd:MTH00109    1 MMMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078193711  81 EVWVSNKVVLGGFLLGLVVEFLMMAYVLEGGEVEVVSGFNGLGDWVVCDVGDSGFSGGEAEGVAALYSYGAWLMVVMGWS 160
Cdd:MTH00109   81 ETWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWS 160

                         170
                  ....*....|....
gi 1078193711 161 LFIGVVVIMEITRG 174
Cdd:MTH00109  161 LFIGVFVIIEITRG 174
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
18-171 1.84e-05

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 42.49  E-value: 1.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078193711  18 VGVSSKPSPIYGGFGLIVGGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEQYPEVWVSNKVVLGGFLLGL 97
Cdd:pfam00499   1 LGVVTSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1078193711  98 VVEFLMMAYVLEGGEVEVVSGfnglgdwvvcdvGDSGFSGGEAEGVaALYSYGAWLMVVMGWSLFIGVVVIMEI 171
Cdd:pfam00499  81 LLLALLLLVLLSASLTPAAAA------------AAPDVGNIEAIGE-LLFTDYLLPFELASVLLLVALVGAIVL 141
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-174 1.76e-70

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 210.81  E-value: 1.76e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078193711   1 MMMYFVFVLSIMFVVSFVGVSSKPSPIYGGFGLIVGGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEQYP 80
Cdd:MTH00109    1 MMMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078193711  81 EVWVSNKVVLGGFLLGLVVEFLMMAYVLEGGEVEVVSGFNGLGDWVVCDVGDSGFSGGEAEGVAALYSYGAWLMVVMGWS 160
Cdd:MTH00109   81 ETWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWS 160

                         170
                  ....*....|....
gi 1078193711 161 LFIGVVVIMEITRG 174
Cdd:MTH00109  161 LFIGVFVIIEITRG 174
ND6 MTH00138
NADH dehydrogenase subunit 6; Provisional
 2-174 6.70e-27

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 177196  Cd Length: 173  Bit Score: 99.83  E-value: 6.70e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078193711   2 MMYFVFVLSIMFVVSFVGVSSKPSPIYGGFGLIVGGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEQYPE 81
Cdd:MTH00138    1 MTYLMSLFLLGLVLGLVAVASNPSPYFAALGLVVVAGVGCGVLVGHGGSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078193711  82 VWVSNKVVlgGFLLGLVVEFLMMAYVLEGGEVEvvsgfnglGDWVVCD-VGDSGFSGGEAEGVAALYSYGAWLMVVMGWS 160
Cdd:MTH00138   81 SWGSWSVL--GYVVGYLVGVVLAAGLFWGGWYE--------GSWVVVDeLKEFSVLRGDVGGVALMYSSGGGMLVICAWV 150

                         170
                  ....*....|....
gi 1078193711 161 LFIGVVVIMEITRG 174
Cdd:MTH00138  151 LLLTLFVVLELTRG 164
ND6 MTH00065
NADH dehydrogenase subunit 6; Provisional
 2-174 2.59e-22

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214415  Cd Length: 172  Bit Score: 87.98  E-value: 2.59e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078193711   2 MMYFVFVLSIMFVVSFVGVSSKPSPIYGGFGLIVGGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEQYPE 81
Cdd:MTH00065    1 MMYLGFLGMLGLVVGLVAVASNPSPYFAALGLVLGAVCGCLVLVELGVSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078193711  82 VWVSNKVVlggFLLGLVVEFLMMAYVLEGGEVEVVSGFNGLGDWVVCDVGDSGfsggeaeGVAALYSYGAWLMVVMGWSL 161
Cdd:MTH00065   81 AWGSWSVL---VYVLFYLLLLIVGYILFGCNFSLEFLFTNYDTEFSVVGYDWG-------GVGLMYSSGGWFLMISGWVL 150

                         170
                  ....*....|...
gi 1078193711 162 FIGVVVIMEITRG 174
Cdd:MTH00065  151 LLTLFVVLEVTRG 163
ND6 MTH00115
NADH dehydrogenase subunit 6; Provisional
 2-175 1.82e-19

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214424  Cd Length: 174  Bit Score: 80.56  E-value: 1.82e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078193711   2 MMYFVFVLSIMFVVSFVGVSSKPSPIYGGFGLIVGGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEQYPE 81
Cdd:MTH00115    1 MMYFVFLLGVCFVLGVVGVASNPSPYYGVVSLVLASVFGCGVLVSLGGSFVSLVLFLVYLGGMLVVFAYSVSLAADPYPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078193711  82 VWVSNKVVLGGFLLGLVVEFLMMAYVLEGGEVEVVSgfnglgdwVVCDVGDSGFSGGEAEGVAALYSYGAWLMVVMGWSL 161
Cdd:MTH00115   81 AWGDWGVVGYVVGFVLVVVVVGVVVGGLWGMEGVGV--------VTVDSGGLFVVRLDFSGVSLFYSSGGGGLLVCGWGL 152

                         170
                  ....*....|....
gi 1078193711 162 FIGVVVIMEITRGS 175
Cdd:MTH00115  153 LLTLFVVLELVRGL 166
ND6 MTH00214
NADH dehydrogenase subunit 6; Provisional
 2-174 2.57e-13

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214461  Cd Length: 168  Bit Score: 64.24  E-value: 2.57e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078193711   2 MMYFVFVLSIMFVVSFVGVSSKPSPIYGGFGLIVGGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEQYPE 81
Cdd:MTH00214    1 MLYFVFLLMFGFLLGLMMVASSPSPYFGALGLVLLALLGCFLLLSHGNSFLGLILFLIYLGGMLVVFSYSAALAADPYPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078193711  82 VWVSNKVVLGGFLLGLVVEFLMMAYvleggevevvSGFNGLGDWVVCDvgdsGFSGGEAEGVAALYSYGAWLMVVMGWSL 161
Cdd:MTH00214   81 SWGGWSVLLFFLFYLLGLGFVGFYF----------YGGWEMLSWMGVD----EANNLDLSGVSDLYSRGFFLLLLGGVVL 146

                         170
                  ....*....|...
gi 1078193711 162 FIGVVVIMEITRG 174
Cdd:MTH00214  147 FLVLFVVLELVRG 159
ND6 MTH00045
NADH dehydrogenase subunit 6; Validated
 2-175 7.05e-10

NADH dehydrogenase subunit 6; Validated


Pssm-ID: 177120  Cd Length: 162  Bit Score: 54.91  E-value: 7.05e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078193711   2 MMYFVFVLSIMFVVSFVGVSSkpSPIYGGFGLIVGGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEQYPE 81
Cdd:MTH00045    1 MVFYLFLILMLFGSTLVFYSL--SPYYSALGLVLVSLSGCLLLSLLGLSFLALLLLLIYMGGMLVVFVYSSALSAERYPS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078193711  82 VWVSNKVVLGGFLLGLVVEFLmmayvleggevevvsgfngLGDWVVCDVGDSGFSGGEAE-GVAALYSYGAWLMVVMGWS 160
Cdd:MTH00045   79 VSNLGEVLVLSLLLSLWVFIS-------------------FDNFLELSNNNWSLVSLSDLvGSSELYNSGGLYLLLGGFI 139

                         170
                  ....*....|....*
gi 1078193711 161 LFIGVVVIMEITRGS 175
Cdd:MTH00045  140 LLVALVVALVISFGH 154
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
18-171 1.84e-05

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 42.49  E-value: 1.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1078193711  18 VGVSSKPSPIYGGFGLIVGGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEQYPEVWVSNKVVLGGFLLGL 97
Cdd:pfam00499   1 LGVVTSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1078193711  98 VVEFLMMAYVLEGGEVEVVSGfnglgdwvvcdvGDSGFSGGEAEGVaALYSYGAWLMVVMGWSLFIGVVVIMEI 171
Cdd:pfam00499  81 LLLALLLLVLLSASLTPAAAA------------AAPDVGNIEAIGE-LLFTDYLLPFELASVLLLVALVGAIVL 141
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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