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Conserved domains on  [gi|1062637824|gb|AOM78485|]
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SusC/RagA family TonB-linked outer membrane protein [Pedobacter steynii]

Protein Classification

SusC/RagA family TonB-linked outer membrane protein( domain architecture ID 1000763)

SusC/RagA family TonB-linked outer membrane protein

Gene Ontology:  GO:0022857|GO:0009279

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
OMP_RagA_SusC super family cl37378
TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade ...
 27-1061 0e+00

TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate]


The actual alignment was detected with superfamily member TIGR04056:

Pssm-ID: 274948 [Multi-domain]  Cd Length: 981  Bit Score: 597.65  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824   27 KVTGVVNDsADGQAIPGASVTIKGKDNATITDANGNFSLQANVNDLIRISYLGYASKEIRITSGTgILKISLEPSLNDLN 106
Cdd:TIGR04056    2 TVTGVVVD-ETGEPLIGASVVVKGTTNGTITDIDGNFSLKVPPGAVLVFSYIGYKTQEVKVKGQK-NLNITLKEDTQELD 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  107 EVVVTALGITKaKKSLGYAVQELKSKDITTAKETNLINSLAGKIAGVQTTNSQGDMG-SSRIIIRGETSISSQNQPLFVV 185
Cdd:TIGR04056   80 EVVVVGYGTQK-KKSLTGAVSTVKAKELKKVPVSNLSNALQGKVAGVIITQSSGEPGgDAEIWIRGISSFGGNNSPLYVI 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  186 DGVPVDNsqflgsggsrdfanTISDINSEDIESISVLKGPNAAALYGSRAAAGVILIKTKtgRGQQG-LGISINSNTTIS 264
Cdd:TIGR04056  159 DGVPRDN--------------GLSDLNPEDIESISVLKDASATAIYGSRGANGVILITTK--RGKEGkPKISYNAEFGFS 222

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  265 NLLTLPTYQNAFGQGSNGK-FSYVDGKGGGVNDGVDE--SWGPALDGRLIPqfNTNGKPEpfiahpdnvrDFFETGYALS 341
Cdd:TIGR04056  223 TPTRLPEMLNAYEYAELYNeALLNRGSSPPDIYTDEEieAYRNGLDPDLYP--NTDWQDE----------IFKRTAFNQR 290

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  342 NGVAIAGSGEKQDVRFSYNNLTQGGILPNSSQNKNSLLLNTTYRITPKLTLNANVNYIKSNAANLPASGGkratGPMLQF 421
Cdd:TIGR04056  291 HNLSVSGGTEKARYYVSLGYYNEEGILKNSDYKRYNFRANIDAKLTKTLKLSLNVSGSLSKYNNPGGSTS----NIWGAL 366

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  422 TWFGRQVDVSQLKKYKDDNGNNINWNNSYYSNPYFIAYENTVSQKRDRIIGSAELNYKITEALSANFRTGNDYYTDRRKI 501
Cdd:TIGR04056  367 MLFPRGTPYSTPPVYSDGYYPAYNSGNTSLQNPYALLNRGYNENERNRLNGNASLEQKITKGLKLKGTFSYDYSNYKNKK 446

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  502 KIA----YGTNGTPFGSYQEDAYTVNENNT-EGRLEFNRKINDdFSINVLGGVNVRTSTLEQNDQMATklavnGLYTLNN 576
Cdd:TIGR04056  447 YYKnpyyYNATGGANNGYYSESNSRSRNYYlEATLNYNRTFGK-HNVSALLGYSQQENKSSSYGGLLD-----DLPSLDA 520

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  577 SRDPLVSSNFYSKLRTYSIFGSAQFGYKDYAFLNVTSRNDWDSSLPKQNLSYFYPSVNGSVVLTEAFDIK--SEVLSFAK 654
Cdd:TIGR04056  521 GTSDASVSGSDSEYRLQSLFGRATYSYKDRYLLEFNFRYDGSSRFAKGNRWGFFPSVSLGWRISEEKFMKklKKWLSFLK 600

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  655 IRGGWSKVG--KATEPYQLVNTYSFTAPF------NGNPQQAASLVEL-NPNLLPEITKSAEAGIELGLFDNRVKFDLSV 725
Cdd:TIGR04056  601 LRASYGIVGndNIGDRYPYLSLYNLGDGGynfgtnNGTSVTGITESRYgNPNLKWEKTKKWNLGLDLGFFNNRLSLTVDY 680

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  726 YNTNSINQILKVNVSSSTGYNQKLINGGSINNKGLEVQLGLTPVKLQDFSWDINLNYALNRSKVTELDKEGLISSYTigt 805
Cdd:TIGR04056  681 YYKKTKDILQSRSLPSVTGYSSPYANIGKVKNKGVELSLNYRNKIGKDFSWSVRGNFTYNKNKILELDEGAYLPVKY--- 757

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  806 nrtvDVLAAIGKPYGTFFG-------TAYQRNADGEILVGAG--------GTPVINPA-KQYLGK-FTPNWLGGISNSFT 868
Cdd:TIGR04056  758 ----PYISKEGGPIGQIYGyiadglfKDDDSPKQTFGNVRPGdikykdvnGDGKIDDDdRVPIGYsNTPDLTYGFGNSFS 833

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  869 YKNINLNFLVDARIGGKVYSNS-----NRTGTYTGVLASTLKGRNTENgGLSYYFPgnvnsgtavgisnggqapggetvy 943
Cdd:TIGR04056  834 YKGFDLSALFQGSGGGDVFNDGrgfypFNGGDWGNVLKIVADNRWTPE-NPNADYP------------------------ 888

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  944 tdgmifdgvladgtrnsRIVPAQQYYKGITNVDEQFIYDASYVKLREVKLSYTLPGQWTKKIGFQNATFSLVGRNLWIIH 1023
Cdd:TIGR04056  889 -----------------RLSYGDSNNSNNYQASTRWLEDGSYLRLKNLTLGYTLPKKWLKKIGISNLRVYFSGQNLFTFS 951

                         1050      1060      1070
                   ....*....|....*....|....*....|....*...
gi 1062637824 1024 KnVPNIDPETafntgnaQGLEDLSLPTARSYGFNLNLK 1061
Cdd:TIGR04056  952 K-YKGWDPEL-------QGNDGGAYPLQRTFSFGVNLT 981
 
Name Accession Description Interval E-value
OMP_RagA_SusC TIGR04056
TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade ...
 27-1061 0e+00

TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 274948 [Multi-domain]  Cd Length: 981  Bit Score: 597.65  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824   27 KVTGVVNDsADGQAIPGASVTIKGKDNATITDANGNFSLQANVNDLIRISYLGYASKEIRITSGTgILKISLEPSLNDLN 106
Cdd:TIGR04056    2 TVTGVVVD-ETGEPLIGASVVVKGTTNGTITDIDGNFSLKVPPGAVLVFSYIGYKTQEVKVKGQK-NLNITLKEDTQELD 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  107 EVVVTALGITKaKKSLGYAVQELKSKDITTAKETNLINSLAGKIAGVQTTNSQGDMG-SSRIIIRGETSISSQNQPLFVV 185
Cdd:TIGR04056   80 EVVVVGYGTQK-KKSLTGAVSTVKAKELKKVPVSNLSNALQGKVAGVIITQSSGEPGgDAEIWIRGISSFGGNNSPLYVI 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  186 DGVPVDNsqflgsggsrdfanTISDINSEDIESISVLKGPNAAALYGSRAAAGVILIKTKtgRGQQG-LGISINSNTTIS 264
Cdd:TIGR04056  159 DGVPRDN--------------GLSDLNPEDIESISVLKDASATAIYGSRGANGVILITTK--RGKEGkPKISYNAEFGFS 222

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  265 NLLTLPTYQNAFGQGSNGK-FSYVDGKGGGVNDGVDE--SWGPALDGRLIPqfNTNGKPEpfiahpdnvrDFFETGYALS 341
Cdd:TIGR04056  223 TPTRLPEMLNAYEYAELYNeALLNRGSSPPDIYTDEEieAYRNGLDPDLYP--NTDWQDE----------IFKRTAFNQR 290

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  342 NGVAIAGSGEKQDVRFSYNNLTQGGILPNSSQNKNSLLLNTTYRITPKLTLNANVNYIKSNAANLPASGGkratGPMLQF 421
Cdd:TIGR04056  291 HNLSVSGGTEKARYYVSLGYYNEEGILKNSDYKRYNFRANIDAKLTKTLKLSLNVSGSLSKYNNPGGSTS----NIWGAL 366

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  422 TWFGRQVDVSQLKKYKDDNGNNINWNNSYYSNPYFIAYENTVSQKRDRIIGSAELNYKITEALSANFRTGNDYYTDRRKI 501
Cdd:TIGR04056  367 MLFPRGTPYSTPPVYSDGYYPAYNSGNTSLQNPYALLNRGYNENERNRLNGNASLEQKITKGLKLKGTFSYDYSNYKNKK 446

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  502 KIA----YGTNGTPFGSYQEDAYTVNENNT-EGRLEFNRKINDdFSINVLGGVNVRTSTLEQNDQMATklavnGLYTLNN 576
Cdd:TIGR04056  447 YYKnpyyYNATGGANNGYYSESNSRSRNYYlEATLNYNRTFGK-HNVSALLGYSQQENKSSSYGGLLD-----DLPSLDA 520

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  577 SRDPLVSSNFYSKLRTYSIFGSAQFGYKDYAFLNVTSRNDWDSSLPKQNLSYFYPSVNGSVVLTEAFDIK--SEVLSFAK 654
Cdd:TIGR04056  521 GTSDASVSGSDSEYRLQSLFGRATYSYKDRYLLEFNFRYDGSSRFAKGNRWGFFPSVSLGWRISEEKFMKklKKWLSFLK 600

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  655 IRGGWSKVG--KATEPYQLVNTYSFTAPF------NGNPQQAASLVEL-NPNLLPEITKSAEAGIELGLFDNRVKFDLSV 725
Cdd:TIGR04056  601 LRASYGIVGndNIGDRYPYLSLYNLGDGGynfgtnNGTSVTGITESRYgNPNLKWEKTKKWNLGLDLGFFNNRLSLTVDY 680

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  726 YNTNSINQILKVNVSSSTGYNQKLINGGSINNKGLEVQLGLTPVKLQDFSWDINLNYALNRSKVTELDKEGLISSYTigt 805
Cdd:TIGR04056  681 YYKKTKDILQSRSLPSVTGYSSPYANIGKVKNKGVELSLNYRNKIGKDFSWSVRGNFTYNKNKILELDEGAYLPVKY--- 757

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  806 nrtvDVLAAIGKPYGTFFG-------TAYQRNADGEILVGAG--------GTPVINPA-KQYLGK-FTPNWLGGISNSFT 868
Cdd:TIGR04056  758 ----PYISKEGGPIGQIYGyiadglfKDDDSPKQTFGNVRPGdikykdvnGDGKIDDDdRVPIGYsNTPDLTYGFGNSFS 833

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  869 YKNINLNFLVDARIGGKVYSNS-----NRTGTYTGVLASTLKGRNTENgGLSYYFPgnvnsgtavgisnggqapggetvy 943
Cdd:TIGR04056  834 YKGFDLSALFQGSGGGDVFNDGrgfypFNGGDWGNVLKIVADNRWTPE-NPNADYP------------------------ 888

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  944 tdgmifdgvladgtrnsRIVPAQQYYKGITNVDEQFIYDASYVKLREVKLSYTLPGQWTKKIGFQNATFSLVGRNLWIIH 1023
Cdd:TIGR04056  889 -----------------RLSYGDSNNSNNYQASTRWLEDGSYLRLKNLTLGYTLPKKWLKKIGISNLRVYFSGQNLFTFS 951

                         1050      1060      1070
                   ....*....|....*....|....*....|....*...
gi 1062637824 1024 KnVPNIDPETafntgnaQGLEDLSLPTARSYGFNLNLK 1061
Cdd:TIGR04056  952 K-YKGWDPEL-------QGNDGGAYPLQRTFSFGVNLT 981
FepA COG4771
Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and ...
 97-791 7.15e-46

Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism];


Pssm-ID: 443803 [Multi-domain]  Cd Length: 612  Bit Score: 175.43  E-value: 7.15e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824   97 SLEPSLNDLNEVVVTALGITKAKKSLGYAVQELKSKDITTAKETNLINSLAgKIAGVQTTNSQGDMGSSRIIIRGetsiS 176
Cdd:COG4771     19 ALAEDATELEEVVVTATRTEQSLSDAPASVSVITAEEIEKLGATDLADALR-LLPGVSVTRSGGRGGSSGISIRG----L 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  177 SQNQPLFVVDGVPVDNSQFLGSGGsrdfantISDINSEDIESISVLKGPnAAALYGSRAAAGVILIKTKTGRGQQGLGIS 256
Cdd:COG4771     94 GGDRVLVLIDGVPVNNPALGGGGD-------LSYIPPDDIERIEVIRGP-ASALYGSDAIGGVINIITKKPTDELEGSVS 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  257 INSNTTISNLLTLptyqNAFGQGSNGKFSYvdgkgggvndgvdeswgpaldgrlipqfntngkpepfiahpdnvrdffet 336
Cdd:COG4771    166 LGYGSNGNGTYSG----SLSLGGPGDKLSF-------------------------------------------------- 191

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  337 gyalsngvAIAGSGEKQDvrfSYNNLTQGGILPNSSQNKNSLLLNTTYRITPKLTLNANVNYIKSNAANLPASGGkratg 416
Cdd:COG4771    192 --------LLSGSYRDRD---GYLDYRNGGFVGNSGYERYNLNAKLGYRLSDNHRLSLSGGYSRQDRDGGPPTLG----- 255

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  417 pmlqftwfgrqvdvsqlkkykddngnninwnnsyySNPYFIAYENTVSQKRDRIIGSAELNYKITEALSANFrtgndyYT 496
Cdd:COG4771    256 -----------------------------------DTEISSDNAGDRDTTTDRGNYSLRYNGDLGDNLDLSL------YY 294

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  497 DRRKIKIAYGTNGTPFGSYQedayTVNENNTEGRLEFNRKINDDFSINVlgGVNVRTSTLEQNDqmatklavnglytlnn 576
Cdd:COG4771    295 SRTDRDSTNGSLGGSTGSFS----DSDDTTYGLELDLTYPLGGNHTLTL--GAEYRYDDLDSSS---------------- 352

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  577 srdplVSSNFYSKLRTYSIFGSAQFGYKDYAFLNVTSRNDWDSSLPKQNLSYFYPSVNGSVVLTEAFdiksevlsfaKIR 656
Cdd:COG4771    353 -----FLGGADASRDTYGLFAQDEWKLTDKLTLTAGLRYDYYSTFGASNYTAFSPRLGLRYDLSDNL----------TLR 417

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  657 GGWSKVGKATEPYQLVNTYSFTAPFNGNPqqaaslvelNPNLLPEITKSAEAGIELGLFDNRVKFDLSVYNTNSINQILK 736
Cdd:COG4771    418 ASYGRGFRAPSLAELYGSGTGTPGRYVLG---------NPDLKPETSDNYELGLEYRLGNGGLSLSLTGFYTDIKDLIVL 488

                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1062637824  737 VNVSSSTGYNQKLINGGSINNKGLEVQLGLTPVKlqdfSWDINLNYALNRSKVTE 791
Cdd:COG4771    489 VPVGPGPGDVLQYENVGKARTYGLELELKYRLGK----GLTLTASYTYLDSKIDD 539
ligand_gated_channel cd01347
TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) ...
 126-794 1.08e-20

TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.


Pssm-ID: 238657 [Multi-domain]  Cd Length: 635  Bit Score: 97.91  E-value: 1.08e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  126 VQELKSKDITtAKETNLINSLAGKIAGVqTTNSQGDMGSSRIIIRGetsiSSQNQPLFVVDGVPVdnsqfLGSGGSRDFA 205
Cdd:cd01347      2 VSVITAEDIE-KQPATSLADLLRRIPGV-SVTRGGGGGGSTISIRG----FGPDRTLVLVDGLPL-----ASSNYGRGVD 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  206 NTIsdINSEDIESISVLKGPnAAALYGSRAAAGVILIKTKtgRGQQGLGISInsnttisnllTLPTYQNAFGQGSNGKFS 285
Cdd:cd01347     71 LNT--IPPELIERVEVLKGP-SSALYGSGAIGGVVNIITK--RPTDEFGGSV----------TAGYGSDNSGSSGGGGFD 135

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  286 YVDGkgggvnDGVDESWGpaldGRLIPQFNTNGKPEPFIAHPDnvrdffetgyalsngvaiagsgekqdvrfsynnltqg 365
Cdd:cd01347    136 VSGA------LADDGAFG----ARLYGAYRDGDGTIDGDGQAD------------------------------------- 168

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  366 gilpNSSQNKNSLLLNTTYRITPKLTLNANVNYIKSnaanlpasggkRATGPMLQFTWFGRQVDVSQLKKYKDDNGNNIN 445
Cdd:cd01347    169 ----DSDEERYNVAGKLDWRPDDDTRLTLDAGYQDQ-----------DADGPGGTLPANGTGSSLGGGPSSNTNGDRDWD 233

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  446 WNNSYYsNPYFIAYENTVSQKRDRIIGSAELNYkitealsANFRTGNDYYTDRRKIKIAYGTNGTPFGSYQEDAYTVNen 525
Cdd:cd01347    234 YRDRYR-KRASLGLEHDLNDTGWTLRANLSYSY-------TDNDGDPLILNGGNNAAGGDLGRSGYSSERDTTQLGFD-- 303

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  526 ntegrLEFNRKINDDF-SINVLGGVNVRTSTLEQNdqmatklavnglytlnnsrdplvssnfysklrTYSIFGSAQFGYK 604
Cdd:cd01347    304 -----AGLNAPFGTGPvAHTLTLGVEYRREELDEK--------------------------------QTALYAQDTIELT 346

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  605 DYAFLNVTSRNDWDSSLPKQNL----------SYFYPSVNGSVVLTEAFdiksevlsfaKIRGGWSKVGKATEPYQLVNT 674
Cdd:cd01347    347 DDLTLTLGLRYDHYDQDSKDTIaggttakksySHWSPSLGLVYKLTDGL----------SLYASYSQGFRAPSLGELYGG 416

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  675 YSFTAPFNGNpqqaaslvelNPNLLPEITKSAEAGIElGLFDNRVKFDLSVYNTNSINQILKVNVSSSTGYNQKLINGGS 754
Cdd:cd01347    417 GSHGGTAAVG----------NPNLKPEKSKQYELGLK-YDPGDGLTLSAALFRIDIKNEIVSTPTNTGLGLVTVYVNGGK 485

                          650       660       670       680
                   ....*....|....*....|....*....|....*....|
gi 1062637824  755 INNKGLEVQLGLTPVKlqdfSWDINLNYALNRSKVTELDK 794
Cdd:cd01347    486 ARIRGVELEASYDLTD----GLGLTGSYTYTDTEVKRTDG 521
CarbopepD_reg_2 pfam13715
CarboxypepD_reg-like domain; This domain family is found in bacteria, archaea and eukaryotes, ...
 28-110 1.92e-18

CarboxypepD_reg-like domain; This domain family is found in bacteria, archaea and eukaryotes, and is approximately 90 amino acids in length. The family is found in association with pfam07715 and pfam00593.


Pssm-ID: 433425 [Multi-domain]  Cd Length: 88  Bit Score: 81.10  E-value: 1.92e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824   28 VTGVVNDSADGQAIPGASVTIKGKDNATITDANGNFSLQA--NVNDLIRISYLGYASKEIRITSGTG---ILKISLEPSL 102
Cdd:pfam13715    1 ISGTVVDENTGEPLPGATVYVKGTTKGTVTDADGNFELKNlpAGTYTLVVSFVGYKTQEKKVTVSNDntlDVNFLLKEDA 80


                   ....*...
gi 1062637824  103 NDLNEVVV 110
Cdd:pfam13715   81 LLLDEVVV 88
PRK13528 PRK13528
outer membrane receptor FepA; Provisional
 122-245 8.82e-10

outer membrane receptor FepA; Provisional


Pssm-ID: 237413 [Multi-domain]  Cd Length: 727  Bit Score: 62.85  E-value: 8.82e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  122 LGYAVQELK---------SKDITTAKETNLINSLAGKIAGVQTT--NSQGDMGSSRII-IRGetsISSQNQpLFVVDGVP 189
Cdd:PRK13528    40 EATAEQELKqqpgvsiitAEDIKKRPPVNDLSDIIRKMPGVNLTgnSASGTRGNNRQIdIRG---MGPENT-LILIDGVP 115

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1062637824  190 VD--NSQFLGSGGSRDfanTISDIN---SEDIESISVLKGPnAAALYGSRAAAGVILIKTK 245
Cdd:PRK13528   116 VTsrNSVRYSWRGERD---TRGDTNwvpPEMVERIEVIRGP-AAARYGSGAAGGVVNIITK 172
 
Name Accession Description Interval E-value
OMP_RagA_SusC TIGR04056
TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade ...
 27-1061 0e+00

TonB-linked outer membrane protein, SusC/RagA family; This model describes a distinctive clade among the TonB-linked outer membrane proteins (OMP). Members of this family are restricted to the Bacteriodetes lineage (except for Gemmatimonas aurantiaca T-27 from the novel phylum Gemmatimonadetes) and occur in high copy numbers, with over 100 members from Bacteroides thetaiotaomicron VPI-5482 alone. Published descriptions of members of this family are available for RagA from Porphyromonas gingivalis, SusC from Bacteroides thetaiotaomicron, and OmpW from Bacteroides caccae. Members form pairs with members of the SusD/RagB family (pfam07980). Transporter complexes including these outer membrane proteins are likely to import large degradation products of proteins (e.g. RagA) or carbohydrates (e.g. SusC) as nutrients, rather than siderophores. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 274948 [Multi-domain]  Cd Length: 981  Bit Score: 597.65  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824   27 KVTGVVNDsADGQAIPGASVTIKGKDNATITDANGNFSLQANVNDLIRISYLGYASKEIRITSGTgILKISLEPSLNDLN 106
Cdd:TIGR04056    2 TVTGVVVD-ETGEPLIGASVVVKGTTNGTITDIDGNFSLKVPPGAVLVFSYIGYKTQEVKVKGQK-NLNITLKEDTQELD 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  107 EVVVTALGITKaKKSLGYAVQELKSKDITTAKETNLINSLAGKIAGVQTTNSQGDMG-SSRIIIRGETSISSQNQPLFVV 185
Cdd:TIGR04056   80 EVVVVGYGTQK-KKSLTGAVSTVKAKELKKVPVSNLSNALQGKVAGVIITQSSGEPGgDAEIWIRGISSFGGNNSPLYVI 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  186 DGVPVDNsqflgsggsrdfanTISDINSEDIESISVLKGPNAAALYGSRAAAGVILIKTKtgRGQQG-LGISINSNTTIS 264
Cdd:TIGR04056  159 DGVPRDN--------------GLSDLNPEDIESISVLKDASATAIYGSRGANGVILITTK--RGKEGkPKISYNAEFGFS 222

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  265 NLLTLPTYQNAFGQGSNGK-FSYVDGKGGGVNDGVDE--SWGPALDGRLIPqfNTNGKPEpfiahpdnvrDFFETGYALS 341
Cdd:TIGR04056  223 TPTRLPEMLNAYEYAELYNeALLNRGSSPPDIYTDEEieAYRNGLDPDLYP--NTDWQDE----------IFKRTAFNQR 290

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  342 NGVAIAGSGEKQDVRFSYNNLTQGGILPNSSQNKNSLLLNTTYRITPKLTLNANVNYIKSNAANLPASGGkratGPMLQF 421
Cdd:TIGR04056  291 HNLSVSGGTEKARYYVSLGYYNEEGILKNSDYKRYNFRANIDAKLTKTLKLSLNVSGSLSKYNNPGGSTS----NIWGAL 366

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  422 TWFGRQVDVSQLKKYKDDNGNNINWNNSYYSNPYFIAYENTVSQKRDRIIGSAELNYKITEALSANFRTGNDYYTDRRKI 501
Cdd:TIGR04056  367 MLFPRGTPYSTPPVYSDGYYPAYNSGNTSLQNPYALLNRGYNENERNRLNGNASLEQKITKGLKLKGTFSYDYSNYKNKK 446

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  502 KIA----YGTNGTPFGSYQEDAYTVNENNT-EGRLEFNRKINDdFSINVLGGVNVRTSTLEQNDQMATklavnGLYTLNN 576
Cdd:TIGR04056  447 YYKnpyyYNATGGANNGYYSESNSRSRNYYlEATLNYNRTFGK-HNVSALLGYSQQENKSSSYGGLLD-----DLPSLDA 520

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  577 SRDPLVSSNFYSKLRTYSIFGSAQFGYKDYAFLNVTSRNDWDSSLPKQNLSYFYPSVNGSVVLTEAFDIK--SEVLSFAK 654
Cdd:TIGR04056  521 GTSDASVSGSDSEYRLQSLFGRATYSYKDRYLLEFNFRYDGSSRFAKGNRWGFFPSVSLGWRISEEKFMKklKKWLSFLK 600

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  655 IRGGWSKVG--KATEPYQLVNTYSFTAPF------NGNPQQAASLVEL-NPNLLPEITKSAEAGIELGLFDNRVKFDLSV 725
Cdd:TIGR04056  601 LRASYGIVGndNIGDRYPYLSLYNLGDGGynfgtnNGTSVTGITESRYgNPNLKWEKTKKWNLGLDLGFFNNRLSLTVDY 680

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  726 YNTNSINQILKVNVSSSTGYNQKLINGGSINNKGLEVQLGLTPVKLQDFSWDINLNYALNRSKVTELDKEGLISSYTigt 805
Cdd:TIGR04056  681 YYKKTKDILQSRSLPSVTGYSSPYANIGKVKNKGVELSLNYRNKIGKDFSWSVRGNFTYNKNKILELDEGAYLPVKY--- 757

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  806 nrtvDVLAAIGKPYGTFFG-------TAYQRNADGEILVGAG--------GTPVINPA-KQYLGK-FTPNWLGGISNSFT 868
Cdd:TIGR04056  758 ----PYISKEGGPIGQIYGyiadglfKDDDSPKQTFGNVRPGdikykdvnGDGKIDDDdRVPIGYsNTPDLTYGFGNSFS 833

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  869 YKNINLNFLVDARIGGKVYSNS-----NRTGTYTGVLASTLKGRNTENgGLSYYFPgnvnsgtavgisnggqapggetvy 943
Cdd:TIGR04056  834 YKGFDLSALFQGSGGGDVFNDGrgfypFNGGDWGNVLKIVADNRWTPE-NPNADYP------------------------ 888

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  944 tdgmifdgvladgtrnsRIVPAQQYYKGITNVDEQFIYDASYVKLREVKLSYTLPGQWTKKIGFQNATFSLVGRNLWIIH 1023
Cdd:TIGR04056  889 -----------------RLSYGDSNNSNNYQASTRWLEDGSYLRLKNLTLGYTLPKKWLKKIGISNLRVYFSGQNLFTFS 951

                         1050      1060      1070
                   ....*....|....*....|....*....|....*...
gi 1062637824 1024 KnVPNIDPETafntgnaQGLEDLSLPTARSYGFNLNLK 1061
Cdd:TIGR04056  952 K-YKGWDPEL-------QGNDGGAYPLQRTFSFGVNLT 981
FepA COG4771
Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and ...
 97-791 7.15e-46

Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism];


Pssm-ID: 443803 [Multi-domain]  Cd Length: 612  Bit Score: 175.43  E-value: 7.15e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824   97 SLEPSLNDLNEVVVTALGITKAKKSLGYAVQELKSKDITTAKETNLINSLAgKIAGVQTTNSQGDMGSSRIIIRGetsiS 176
Cdd:COG4771     19 ALAEDATELEEVVVTATRTEQSLSDAPASVSVITAEEIEKLGATDLADALR-LLPGVSVTRSGGRGGSSGISIRG----L 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  177 SQNQPLFVVDGVPVDNSQFLGSGGsrdfantISDINSEDIESISVLKGPnAAALYGSRAAAGVILIKTKTGRGQQGLGIS 256
Cdd:COG4771     94 GGDRVLVLIDGVPVNNPALGGGGD-------LSYIPPDDIERIEVIRGP-ASALYGSDAIGGVINIITKKPTDELEGSVS 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  257 INSNTTISNLLTLptyqNAFGQGSNGKFSYvdgkgggvndgvdeswgpaldgrlipqfntngkpepfiahpdnvrdffet 336
Cdd:COG4771    166 LGYGSNGNGTYSG----SLSLGGPGDKLSF-------------------------------------------------- 191

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  337 gyalsngvAIAGSGEKQDvrfSYNNLTQGGILPNSSQNKNSLLLNTTYRITPKLTLNANVNYIKSNAANLPASGGkratg 416
Cdd:COG4771    192 --------LLSGSYRDRD---GYLDYRNGGFVGNSGYERYNLNAKLGYRLSDNHRLSLSGGYSRQDRDGGPPTLG----- 255

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  417 pmlqftwfgrqvdvsqlkkykddngnninwnnsyySNPYFIAYENTVSQKRDRIIGSAELNYKITEALSANFrtgndyYT 496
Cdd:COG4771    256 -----------------------------------DTEISSDNAGDRDTTTDRGNYSLRYNGDLGDNLDLSL------YY 294

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  497 DRRKIKIAYGTNGTPFGSYQedayTVNENNTEGRLEFNRKINDDFSINVlgGVNVRTSTLEQNDqmatklavnglytlnn 576
Cdd:COG4771    295 SRTDRDSTNGSLGGSTGSFS----DSDDTTYGLELDLTYPLGGNHTLTL--GAEYRYDDLDSSS---------------- 352

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  577 srdplVSSNFYSKLRTYSIFGSAQFGYKDYAFLNVTSRNDWDSSLPKQNLSYFYPSVNGSVVLTEAFdiksevlsfaKIR 656
Cdd:COG4771    353 -----FLGGADASRDTYGLFAQDEWKLTDKLTLTAGLRYDYYSTFGASNYTAFSPRLGLRYDLSDNL----------TLR 417

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  657 GGWSKVGKATEPYQLVNTYSFTAPFNGNPqqaaslvelNPNLLPEITKSAEAGIELGLFDNRVKFDLSVYNTNSINQILK 736
Cdd:COG4771    418 ASYGRGFRAPSLAELYGSGTGTPGRYVLG---------NPDLKPETSDNYELGLEYRLGNGGLSLSLTGFYTDIKDLIVL 488

                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1062637824  737 VNVSSSTGYNQKLINGGSINNKGLEVQLGLTPVKlqdfSWDINLNYALNRSKVTE 791
Cdd:COG4771    489 VPVGPGPGDVLQYENVGKARTYGLELELKYRLGK----GLTLTASYTYLDSKIDD 539
CirA COG1629
Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];
105-793 1.02e-42

Outer membrane receptor protein, Fe transport [Inorganic ion transport and metabolism];


Pssm-ID: 441236 [Multi-domain]  Cd Length: 644  Bit Score: 166.54  E-value: 1.02e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  105 LNEVVVTALGITKAKKSLGYAVQELKSKDITTAKETNLINSLaGKIAGVQTTNSQGdmGSSRIIIRGetSISSQNQPLFV 184
Cdd:COG1629      1 LEEVVVTATRTDESLQDVPGSVSVISREQLEDQPATDLGDLL-RRVPGVSVTSAGG--GAGQISIRG--FGGGGNRVLVL 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  185 VDGVPVDNSQFLGSGgsrdfantISDINSEDIESISVLKGPnAAALYGSRAAAGVILIKTKtgRGQQGLGISINSNTtis 264
Cdd:COG1629     76 VDGVPLNDPSGGDGG--------LSYIDPEDIERVEVLRGP-SSALYGSGALGGVINIVTK--KPKDGKGGEVSASY--- 141

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  265 nlltlptyqnafgqGSNGKFSYvdgkgggvndgvdeswgpaldgrlipqfntngkpepfiahpdnvrdffetgyalsnGV 344
Cdd:COG1629    142 --------------GSYGTYRA--------------------------------------------------------SL 151

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  345 AIAGSGEKQDVRFSYNNLTQGGILPNSSQNKNSLLLNTTYRITPKLTLNANVNYIKSNAaNLPASGGKRATGPmlqftwf 424
Cdd:COG1629    152 SLSGGNGKLAYRLSASYRDSDGYRDNSDSDRYNLRAKLGYQLGDDTRLTLSASYSDSDQ-DSPGYLTLAALRP------- 223

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  425 grqvdvsqlkkykddngnninwnNSYYSNPYFIAYENTVSQKRDRIIGSAELNYkITEALSANFRTGndYYTDRRKIKIA 504
Cdd:COG1629    224 -----------------------RGAMDDGTNPYSNDTDDNTRDRYSLSLEYEH-LGDGLKLSASAY--YRYDDTDLDSD 277

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  505 YGTNGTPFGSYQEDAYTVNENNTEGRLEFNRKINDDFSINVlgGVNVRTSTLEQNDQmATKLAVNGLYTLNNSRDplvss 584
Cdd:COG1629    278 FTPTPADGGTLEQTDFDNRTYGLELRLTYDLGFGGKHTLLV--GLDYQRQDLDGSGY-PLDLGSGSLPTLTSGAD----- 349

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  585 nFYSKLRTYSIFGSAQFGYKDYAFLNVTSRNDWDSSLPKQNLSYFYPSVNGsvvlteafdiKSEVLSFAKIRGGWskvgK 664
Cdd:COG1629    350 -DDGTTTSLALYAQDTYKLTDKLTLTAGLRYDYVSYDVDDTVTGTDSASGS----------RSYSAFSPSLGLTY----Q 414

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  665 ATEPYQLVNTYS--FTAPFNG--NPQQAASLVELNPNLLPEITKSAEAGIELGLFDNRVKFDLSVYNTNSINQILKVNVS 740
Cdd:COG1629    415 LSPNLSLYASYSrgFRAPTFGelYANGTDPYSVGNPDLKPETSTNYELGLRYRLLDGRLSLSLALFYSDVDNEILSVPLP 494

                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1062637824  741 SSTGYNQKLINGGSINNKGLEVQLGLTPVKlqdfSWDINLNYALNRSKVTELD 793
Cdd:COG1629    495 NDSGFSTYYTNAGKARSYGVELELSYQLTP----GLSLNASYSYTDAKFDDDT 543
BtuB COG4206
Outer membrane cobalamin receptor protein BtuB [Coenzyme transport and metabolism];
108-302 4.94e-33

Outer membrane cobalamin receptor protein BtuB [Coenzyme transport and metabolism];


Pssm-ID: 443355 [Multi-domain]  Cd Length: 276  Bit Score: 129.22  E-value: 4.94e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  108 VVVTALGITKAKKSLGYAVQELKSKDITTAKETNLINSLAgKIAGVQTTNSQGDMGSSRIIIRGETSissqNQPLFVVDG 187
Cdd:COG4206      1 VVVTATRLEQSKSDLTGSVTVIDAEELERSGATSLADALR-RVPGVQVSSSGGPGSAASISIRGLGS----NQTLVLIDG 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  188 VPVDNSQflgsGGSRDFantiSDINSEDIESISVLKGPnAAALYGSRAAAGVILIKTKTGRGQQGLGISIN--SNTTISN 265
Cdd:COG4206     76 VPLNDPS----LGGVDL----SLIPPDDIERIEVLKGA-ASALYGSDAIGGVINITTKKGKKGFKGSVSASygSFGTRRL 146

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 1062637824  266 LLTLPTYQNAFGQGSNGKFSYVDGKGGGVNDGVDESW 302
Cdd:COG4206    147 SASLSGGAGKFSYSLSASYRRSDGYRYNDPDLRNNDG 183
ligand_gated_channel cd01347
TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) ...
 126-794 1.08e-20

TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel. Energy (proton-motive force) and TonB-dependent conformational alteration of channel (parts of plug, and loops 7 and 8) allow passage of ligand. FepA residues 12-18 form the TonB box, which mediates the interaction with the TonB-containing inner membrane complex. TonB preferentially interacts with ligand-bound receptors. Transport thru the channel may resemble passage thru an air lock. In this model, ligand binding leads to closure of the extracellular end of pore, then a TonB-mediated signal facillitates opening of the interior side of pore, deforming the N-terminal plug and allowing passage of the ligand to the periplasm. Such a mechanism would prevent the free diffusion of small molecules thru the pore.


Pssm-ID: 238657 [Multi-domain]  Cd Length: 635  Bit Score: 97.91  E-value: 1.08e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  126 VQELKSKDITtAKETNLINSLAGKIAGVqTTNSQGDMGSSRIIIRGetsiSSQNQPLFVVDGVPVdnsqfLGSGGSRDFA 205
Cdd:cd01347      2 VSVITAEDIE-KQPATSLADLLRRIPGV-SVTRGGGGGGSTISIRG----FGPDRTLVLVDGLPL-----ASSNYGRGVD 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  206 NTIsdINSEDIESISVLKGPnAAALYGSRAAAGVILIKTKtgRGQQGLGISInsnttisnllTLPTYQNAFGQGSNGKFS 285
Cdd:cd01347     71 LNT--IPPELIERVEVLKGP-SSALYGSGAIGGVVNIITK--RPTDEFGGSV----------TAGYGSDNSGSSGGGGFD 135

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  286 YVDGkgggvnDGVDESWGpaldGRLIPQFNTNGKPEPFIAHPDnvrdffetgyalsngvaiagsgekqdvrfsynnltqg 365
Cdd:cd01347    136 VSGA------LADDGAFG----ARLYGAYRDGDGTIDGDGQAD------------------------------------- 168

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  366 gilpNSSQNKNSLLLNTTYRITPKLTLNANVNYIKSnaanlpasggkRATGPMLQFTWFGRQVDVSQLKKYKDDNGNNIN 445
Cdd:cd01347    169 ----DSDEERYNVAGKLDWRPDDDTRLTLDAGYQDQ-----------DADGPGGTLPANGTGSSLGGGPSSNTNGDRDWD 233

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  446 WNNSYYsNPYFIAYENTVSQKRDRIIGSAELNYkitealsANFRTGNDYYTDRRKIKIAYGTNGTPFGSYQEDAYTVNen 525
Cdd:cd01347    234 YRDRYR-KRASLGLEHDLNDTGWTLRANLSYSY-------TDNDGDPLILNGGNNAAGGDLGRSGYSSERDTTQLGFD-- 303

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  526 ntegrLEFNRKINDDF-SINVLGGVNVRTSTLEQNdqmatklavnglytlnnsrdplvssnfysklrTYSIFGSAQFGYK 604
Cdd:cd01347    304 -----AGLNAPFGTGPvAHTLTLGVEYRREELDEK--------------------------------QTALYAQDTIELT 346

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  605 DYAFLNVTSRNDWDSSLPKQNL----------SYFYPSVNGSVVLTEAFdiksevlsfaKIRGGWSKVGKATEPYQLVNT 674
Cdd:cd01347    347 DDLTLTLGLRYDHYDQDSKDTIaggttakksySHWSPSLGLVYKLTDGL----------SLYASYSQGFRAPSLGELYGG 416

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  675 YSFTAPFNGNpqqaaslvelNPNLLPEITKSAEAGIElGLFDNRVKFDLSVYNTNSINQILKVNVSSSTGYNQKLINGGS 754
Cdd:cd01347    417 GSHGGTAAVG----------NPNLKPEKSKQYELGLK-YDPGDGLTLSAALFRIDIKNEIVSTPTNTGLGLVTVYVNGGK 485

                          650       660       670       680
                   ....*....|....*....|....*....|....*....|
gi 1062637824  755 INNKGLEVQLGLTPVKlqdfSWDINLNYALNRSKVTELDK 794
Cdd:cd01347    486 ARIRGVELEASYDLTD----GLGLTGSYTYTDTEVKRTDG 521
FecA COG4772
Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism];
104-791 4.31e-19

Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism];


Pssm-ID: 443804 [Multi-domain]  Cd Length: 681  Bit Score: 92.68  E-value: 4.31e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  104 DLNEVVVTALGITKAK-KSLGYAVQELKSKDITTAKETNLINSLAgKIAGVQTTNSQGDMGSSRIIIRGETSISSQNQpL 182
Cdd:COG4772     22 TLETVVVTGSRAAEARlKDVPGSVSVVDREELENQAATSLREVLR-RVPGVNVQEEDGFGLRPNIGIRGLGPRRSRGI-T 99

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  183 FVVDGVPVDNSQFlgSGGSRDFANTIsdinsEDIESISVLKGPNAAaLYGSRAAAGVILIKTKTGRGQQGLGISINsntt 262
Cdd:COG4772    100 LLEDGIPIAPAPY--GDPAAYYFPDL-----ERMERIEVLRGAAAL-RYGPQTVGGAINFVTRTIPTAFGGELRVT---- 167

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  263 isnlltlptyqnafgQGSNGKFSYvdgkgggvndgvdeswgpaldgrlipqfntngkpepfiahpdnvrdffetgyalsn 342
Cdd:COG4772    168 ---------------GGSFGYRRT-------------------------------------------------------- 176

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  343 GVAIAGSGEKQDVRFSYNNLTQGGILPNSSQNKNSLLLNTTYRITPKLTLNANVNYIKSNaANLPasGGkratgpmlqFT 422
Cdd:COG4772    177 HASVGGTVGNFGYLVEYSRKRGDGFRDNSGFDINDFNAKLGYRLSDRQELTLKFQYYDED-ANTP--GG---------LT 244

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  423 WFgrqvdvsqlkkykddngnninwnnSYYSNPYFiAYENTVSQKRDRIIGSAELNYKITEALSANFRTgndYYTDRR--- 499
Cdd:COG4772    245 DA------------------------QFDADPRQ-SYRPADQFDTRRTQLSLRYEHQLSDNTTLTTTA---YYNDFSrnw 296

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  500 KIKIAYGTNGTPFGSYQEDAYTVNENNTEGRLEFNRKINDDFSiNVLGGVN-VRTSTLEQNDQMATKLAVNGLYTLNNSR 578
Cdd:COG4772    297 YIRQNTADPNTPGLGLRGNPRGYRSYGIEPRLTHRFELGGVPH-TLEVGLRyHREEEDRKQYVNTYGQGRSGAGLRRDRR 375

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  579 DPlvssnfyskLRTYSIFGSAQFGYKD---------YAFLNvTSRNDWDSSLPKQNLSY------FYPSVNGSVVLTEAf 643
Cdd:COG4772    376 FS---------ADALAAYAQNRFELTGrltltpglrYEHIR-RDRTDRYSTRTGGDDSGsnsyseFLPGLGLLYQLTDN- 444

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  644 diksevlsfAKIRGGWSKvgkatepyqlvntySFTAPfngNPQQAASLVELNPNLLPEITKSAEAGIElGLFDNRVKFDL 723
Cdd:COG4772    445 ---------LQLYANVSR--------------GFEPP---TFGDLAYGNGGNPDLKPEKSWNYELGTR-GRIGNGLSAEV 497

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1062637824  724 SVYNTNSINQIlkVNVSSSTGYNQKLINGGSINNKGLEVQLGLTPVKLQDFSWDINLNYALNRSKVTE 791
Cdd:COG4772    498 ALFYIDYDNEL--GSCSAAGGDRSTFTNAGETRHQGLELALDYDLLKGGGLGLPLFAAYTYTDAEFTS 563
CarbopepD_reg_2 pfam13715
CarboxypepD_reg-like domain; This domain family is found in bacteria, archaea and eukaryotes, ...
 28-110 1.92e-18

CarboxypepD_reg-like domain; This domain family is found in bacteria, archaea and eukaryotes, and is approximately 90 amino acids in length. The family is found in association with pfam07715 and pfam00593.


Pssm-ID: 433425 [Multi-domain]  Cd Length: 88  Bit Score: 81.10  E-value: 1.92e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824   28 VTGVVNDSADGQAIPGASVTIKGKDNATITDANGNFSLQA--NVNDLIRISYLGYASKEIRITSGTG---ILKISLEPSL 102
Cdd:pfam13715    1 ISGTVVDENTGEPLPGATVYVKGTTKGTVTDADGNFELKNlpAGTYTLVVSFVGYKTQEKKVTVSNDntlDVNFLLKEDA 80


                   ....*...
gi 1062637824  103 NDLNEVVV 110
Cdd:pfam13715   81 LLLDEVVV 88
Plug pfam07715
TonB-dependent Receptor Plug Domain; The Plug domain has been shown to be an independently ...
 118-239 3.23e-17

TonB-dependent Receptor Plug Domain; The Plug domain has been shown to be an independently folding subunit of the TonB-dependent receptors. It acts as the channel gate, blocking the pore until the channel is bound by ligand. At this point it under goes conformational changes opens the channel.


Pssm-ID: 462243 [Multi-domain]  Cd Length: 107  Bit Score: 78.08  E-value: 3.23e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  118 AKKSLGYAVQELKSKDITTAKETNLINSLAGkIAGVQTTNSQGDmGSSRIIIRGetsiSSQNQPLFVVDGVPVDNSQflg 197
Cdd:pfam07715    1 DLRDTPGSVSVVTAEDIEDQGATNLADALRG-VPGVSVSSGGGG-GGSSISIRG----FGSNRVLVLVDGVPLNSGG--- 71

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1062637824  198 sggsrDFANTISDINSEDIESISVLKGPnAAALYGSRAAAGV 239
Cdd:pfam07715   72 -----GGSVDLNSIDPEDIERVEVLKGP-ASALYGSGAIGGV 107
FhuE COG4773
Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion ...
 150-791 3.70e-13

Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid [Inorganic ion transport and metabolism];


Pssm-ID: 443805 [Multi-domain]  Cd Length: 692  Bit Score: 73.78  E-value: 3.70e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  150 IAGVQTTNSQGDmGSSRIIIRGETSISSQnqplfvVDGVPVDNSqflgSGGSRDFANtisdinsedIESISVLKGPnAAA 229
Cdd:COG4773     92 VPGVTVSSYDGG-GRDSFSIRGFSIDNYL------RDGLPLGGF----GGGQPDTAN---------LERVEVLKGP-AGL 150

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  230 LYGSRAAAGVILIKTKTGRGQQGLGISInsnttisnlltlpTYqnafgqGSNGKFSY-VDGkGGGVNDgvDESWGpaldG 308
Cdd:COG4773    151 LYGAGSPGGLVNLVTKRPTAEPQGEVSL-------------SA------GSWDTYRAtADV-GGPLNE--DGTLR----Y 204

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  309 RLIpqfntngkpepfiahpdnvrdffetgyalsngvaiaGSGEKQDvrfSYnnltqggiLPNSSQNKNSLLLNTTYRITP 388
Cdd:COG4773    205 RLN------------------------------------AAYEDGD---SF--------RDGVDNRRTLIAPSLDWDLTD 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  389 KLTLNANVNYIKSnaanlpasggkRATGPMLQFTWFGRQVDVSqlkkykddngnninwNNSYYSNPYFiayentvSQKRD 468
Cdd:COG4773    238 DTTLTLGAEYQDD-----------DSTGDRGFLPLDGTLLDLP---------------RSTNLGEPWD-------YYDTE 284

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  469 RIIGSAELNYKITEALSANFRTGNDYYTDRRKIKIAYGTNGTPFGSYQEDAYTVNENNTEGRLEFNrkINDDFSI----- 543
Cdd:COG4773    285 TTTLFAELEHRFNDDWSLRANARYSDSDRDGRSAYAYGAPDAATGTLTRYASARDGDSRSDSLDAN--LNGKFETggleh 362

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  544 NVLGGVNVRTSTLEQNDQMATKLAVNGLYTLNNSRDPLVSSNFYSKLRTYSIFGSAQFGYKDYAFLNVTSRNDWdsslpk 623
Cdd:COG4773    363 TLLVGADYSRYDSDSDSATAGTINIYNPVYGNLPEPDFDASDTDTTTRQTGLYAQDQISLTDRLSLLLGGRYDW------ 436

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  624 qnlsYFYPSVNGSVVLTEAFDiKSEVLSFA----KIRGGWSkvgkatePYqlvntYSFTAPFNGNPQQAASlvelNPNLL 699
Cdd:COG4773    437 ----YETDSTNRLGGSTTSYD-DSAFTPRAglvyDLTPGLS-------LY-----ASYSESFEPQSGADNN----GNPLD 495

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  700 PEITKSAEAGIELGLFDNRVKFDLSVYntnsinQILKVNVSSSTGYNQ-KLINGGSINNKGLEVQLGLTPVKlqdfSWDI 778
Cdd:COG4773    496 PETGKQYEAGVKGELFDGRLNATLAVF------DITQKNVATTDPDNPnFYVQVGEVRSRGVELELSGELTP----GLNL 565

                          650
                   ....*....|...
gi 1062637824  779 NLNYALNRSKVTE 791
Cdd:COG4773    566 IAGYTYTDAKITK 578
Fiu COG4774
Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism];
151-791 5.80e-12

Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism];


Pssm-ID: 443806 [Multi-domain]  Cd Length: 639  Bit Score: 69.91  E-value: 5.80e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  151 AGVQTTNSQGDMGSsRIIIRGETSISSqnqplFVVDGVPVDNSQFlgsggsrdfantisdINSEDIESISVLKGPnAAAL 230
Cdd:COG4774     37 PGVTFGAGEGGNGD-SFSIRGFSASGD-----IYVDGLRDPGQYR---------------RDTFNLERVEVLKGP-ASVL 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  231 YGSRAAAGVILIKTKTgrgqqglgisinsnttisnlltlPTYQNAF-GQGSNGKFSYVDGkGGGVNDGVDESWGpaldgr 309
Cdd:COG4774     95 YGRGSPGGVINLVTKR-----------------------PTDEPFTeVTLTYGSDGQRRA-TLDVNGPLGDDLA------ 144

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  310 lipqfntngkpepfiahpdnVRdffetgyalsngvaIAGSGEKQDVRFSYNNLTQGGILPnssqnknSLllntTYRITPK 389
Cdd:COG4774    145 --------------------YR--------------LNGMYRDSDSYRDGVDNDRWGIAP-------SL----TWRLGDR 179

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  390 LTLNANVNYIKSNaaNLPASGgkratgpmLQFTWFGRQVDVSqlkkykddngnninwNNSYYSNPYfiAYENTVSQkrdr 469
Cdd:COG4774    180 TRLTLDYEYQDDD--RTPDYG--------VPAVANGRPVDVD---------------RSTFYGQPD--DYSDSETD---- 228

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  470 iIGSAELNYKITEALSANFRTGndYYTDRRKIKIAYGTNGTPFGSYQEDAYTVNENNT--EGRLEFNRKIN-DDFSINVL 546
Cdd:COG4774    229 -SATLRLEHDFNDNWTLRNALR--YSDYDRDYRNTYPTGGNATGTVTRSAYRRDQDNDtlSNQTDLTGKFDtGGVKHTLL 305

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  547 GGVNVR--TSTLEQNDQMATKLAV---NGLYTLNNSRDPLVSSNFYSKLRTYSIFGSAQFGYKDYAFLNVTSRNDWdssl 621
Cdd:COG4774    306 AGVEYSreDSDNARYSGGGTAPTVnlyNPVYGAPVTGPTLGGADNDSRTDTTGLYLQDTISLTDRWSLLAGLRYDR---- 381

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  622 pkqnlsyfypsvngsvVLTEAFDIKSEVLSFAKIRGGWS-KVG---KATEPyqlVNTY-----SFTaPFNGNPQQAASlv 692
Cdd:COG4774    382 ----------------FDTDYTDRTTGATTSSYDDSAFSpRAGlvyKPTPN---LSLYasystSFN-PGGGAPSLSNA-- 439

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  693 elNPNLLPEITKSAEAGIELGLFDNRVKFDLSVYntnsinQILKVNVSSSTGYNQKL-INGGSINNKGLEVQLGLTPVKl 771
Cdd:COG4774    440 --GQALDPEKSRQYEVGVKWDLLDGRLSLTAALF------RIEKTNVRTTDPANPGVyVQTGEQRSRGVELEATGELTP- 510

                          650       660
                   ....*....|....*....|
gi 1062637824  772 qdfSWDINLNYALNRSKVTE 791
Cdd:COG4774    511 ---GWSVLAGYTYLDAEITK 527
TonB_dep_Rec pfam00593
TonB dependent receptor; This model now only covers the conserved part of the barrel structure.
 449-783 1.26e-11

TonB dependent receptor; This model now only covers the conserved part of the barrel structure.


Pssm-ID: 395474 [Multi-domain]  Cd Length: 475  Bit Score: 68.26  E-value: 1.26e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  449 SYYSNPYFIAYENTVSQKRDRIIGSAELNYKITEALSANFRTGNDYYTDRRKIKIAYGTNGTpFGSYQEDAYTVNENNTE 528
Cdd:pfam00593   42 GYLGDRPLYYGRDYSDTDRKRLSLGYDYDLGDGLSWLSTLRLGLRYSSLDGDYTSNSSGLSG-AGDYLSDDRLYGLYGLD 120

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  529 GRLEFNRKINDDFSInvlgGVNVRTSTLEQNDQMATKlavnglYTLNNSRDPLVSSNFYSKLRTYSIFGSAQFGYKDYAF 608
Cdd:pfam00593  121 GDLELSLDLSHDLLL----GVELRTAGLDYRRLDDDA------YDPYDPANPSSSSYSDTTTDSYGLYLQDNIKLTDRLT 190

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  609 LNVTSRNDWDSSLPKQNLSYFYPSVNGSVVLTEAFDIKSEVLSFAKIRGGWSKVGKATEPYQLVNTYSFTAPFNGNPQqa 688
Cdd:pfam00593  191 LTLGLRYDHYSTDGDDGNGGGDNFSRSYSAFSPRLGLVYKPTDNLSLYASYSRGFRAPSLGELYGSGSGGGGGAVAGG-- 268

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  689 aslvelNPNLLPEITKSAEAGIElgLFDNRVKFDLSVYNTNSINQILKV-NVSSSTGYNQKLINGGSINNKGLEVQLGLT 767
Cdd:pfam00593  269 ------NPDLKPETSDNYELGLK--YDDGRLSLSLALFYIDIKNLITSDpDGPGLGGTVYTYTNVGKARIRGVELELSGR 340

                          330
                   ....*....|....*.
gi 1062637824  768 PvklqdfsWDINLNYA 783
Cdd:pfam00593  341 L-------WGLGLSGG 349
SusC_RagA_signa TIGR04057
TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; This model ...
 215-245 2.66e-10

TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; This model describes a 31-residue signature region of the SusC/RagA family of outer membrane proteins from the Bacteriodetes. While many TonB-dependent outer membrane receptors are associated with siderophore import, this family seems to include generalized nutrient receptors that may convey fairly large oligomers of protein or carbohydrate. This family occurs in high copy numbers in the most abundant species of the human gut microbiome.


Pssm-ID: 274949 [Multi-domain]  Cd Length: 31  Bit Score: 56.05  E-value: 2.66e-10
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1062637824  215 DIESISVLKGPNAAALYGSRAAAGVILIKTK 245
Cdd:TIGR04057    1 DIESISVLKDASAAAIYGSRGANGVILITTK 31
PRK13528 PRK13528
outer membrane receptor FepA; Provisional
 122-245 8.82e-10

outer membrane receptor FepA; Provisional


Pssm-ID: 237413 [Multi-domain]  Cd Length: 727  Bit Score: 62.85  E-value: 8.82e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  122 LGYAVQELK---------SKDITTAKETNLINSLAGKIAGVQTT--NSQGDMGSSRII-IRGetsISSQNQpLFVVDGVP 189
Cdd:PRK13528    40 EATAEQELKqqpgvsiitAEDIKKRPPVNDLSDIIRKMPGVNLTgnSASGTRGNNRQIdIRG---MGPENT-LILIDGVP 115

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1062637824  190 VD--NSQFLGSGGSRDfanTISDIN---SEDIESISVLKGPnAAALYGSRAAAGVILIKTK 245
Cdd:PRK13528   116 VTsrNSVRYSWRGERD---TRGDTNwvpPEMVERIEVIRGP-AAARYGSGAAGGVVNIITK 172
PRK13524 PRK13524
FepA family TonB-dependent siderophore receptor;
103-245 2.33e-08

FepA family TonB-dependent siderophore receptor;


Pssm-ID: 237410 [Multi-domain]  Cd Length: 744  Bit Score: 58.12  E-value: 2.33e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  103 NDLNEVVVTALGITKakKSLGYAVqeLKSKDITTAKETNLINSLAGKIAGVQTT-NS-QGDMGSSRII-IRGetsISSQN 179
Cdd:PRK13524    36 SHEDTIVVTAAEQNL--QAPGVST--ITAEDIRKRPPANDVSEIIRTMPGVNLTgNStSGQRGNNRQIdIRG---MGPEN 108

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1062637824  180 QpLFVVDGVPVD--NSQFLGSGGSRDfanTISDIN---SEDIESISVLKGPnAAALYGSRAAAGVILIKTK 245
Cdd:PRK13524   109 T-LILIDGKPVSsrNSVRYGWRGERD---TRGDTNwvpPEMIERIEVLRGP-AAARYGNGAAGGVVNIITK 174
CarboxypepD_reg pfam13620
Carboxypeptidase regulatory-like domain;
28-86 2.25e-06

Carboxypeptidase regulatory-like domain;


Pssm-ID: 433354 [Multi-domain]  Cd Length: 81  Bit Score: 46.50  E-value: 2.25e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1062637824   28 VTGVVNDsADGQAIPGASVTIKGKDNA----TITDANGNFSLqANV---NDLIRISYLGYASKEIR 86
Cdd:pfam13620    2 ISGTVTD-PSGAPVPGATVTVTNTDTGtvrtTTTDADGRYRF-PGLppgTYTVTVSAPGFKTATRT 65
PRK10064 PRK10064
catecholate siderophore receptor CirA; Provisional
 94-289 4.48e-06

catecholate siderophore receptor CirA; Provisional


Pssm-ID: 236646 [Multi-domain]  Cd Length: 663  Bit Score: 50.65  E-value: 4.48e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824   94 LKISLEPSLNDLNEVVVTALGITKAKKSLGYAVQELKSKDITTAKETNLINSLaGKIAGVQTTNSqgdmGSSR--IIIRG 171
Cdd:PRK10064    19 CAWPVLAVDDDGETMVVTASAVEQNLKDAPASISVITQEDLQRKPVQNLKDVL-KEVPGVQLTNE----GDNRkgVSIRG 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  172 ETSissqNQPLFVVDGVPVD--NSQFLGSggsrDFanTISDINSEDIESISVLKGPnAAALYGSRAAAGVILIKTKTgRG 249
Cdd:PRK10064    94 LDS----SYTLILIDGKRVNsrNAVFRHN----DF--DLNWIPVDAIERIEVVRGP-MSSLYGSDALGGVVNIITKK-IG 161

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 1062637824  250 QQGLGiSINSNTTISNlltlptyQNAFGQGSNGKFsYVDG 289
Cdd:PRK10064   162 QKWHG-TVTVDTTIQE-------HRDRGDTYNGQF-FTSG 192
PRK13486 PRK13486
TonB-dependent receptor;
108-265 1.58e-05

TonB-dependent receptor;


Pssm-ID: 139606 [Multi-domain]  Cd Length: 696  Bit Score: 48.86  E-value: 1.58e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  108 VVVTALGITKAKKSLGYAVQELKSKDITTAKETNLINSLAGkIAGVQTTNSQGDMGSSRIIIRGETSissqNQPLFVVDG 187
Cdd:PRK13486    28 MIVSASGYEKKLTNAAASVSVISQEELQSSQYHDLAEALRS-VEGVDVESGTGKTGGLEISIRGMPA----SYTLILIDG 102

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  188 VPvdnsqflgSGGSRDFA-NTISDINS------EDIESISVLKGPnAAALYGSRAAAGVILIKTKTGRGQQGLGISINSN 260
Cdd:PRK13486   103 VR--------QGGSSDVTpNGFSAMNTgfmpplAAIERIEVIRGP-MSTLYGSDAMGGVVNIITRKNADKWLSSVNAGLN 173


                   ....*
gi 1062637824  261 TTISN 265
Cdd:PRK13486   174 LQESN 178
PRK13484 PRK13484
IreA family TonB-dependent siderophore receptor;
93-268 7.96e-05

IreA family TonB-dependent siderophore receptor;


Pssm-ID: 139605 [Multi-domain]  Cd Length: 682  Bit Score: 46.54  E-value: 7.96e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824   93 ILKISLEPSLNDLNEVVVTALGITKAKKSLGYAVQELKSKDIttakETNLINSLAGKIAGVQTTNSQGDMGSSRIIIRGe 172
Cdd:PRK13484    18 VISSGYASSDKKEDTLVVTASGFTQQLRNAPASVSVITSEQL----QKKPVSDLVDAVKDVEGISITGGNEKPDISIRG- 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  173 tsiSSQNQPLFVVDGVPVDN--SQFLGSGGSRdfANTISDInsEDIESISVLKGPnAAALYGSRAAAGVILIKTK----- 245
Cdd:PRK13484    93 ---LSGDYTLILVDGRRQSGreSRPNGSGGFE--AGFIPPV--EAIERIEVIRGP-MSSLYGSDAIGGVINIITKpvnnq 164

                          170       180
                   ....*....|....*....|...
gi 1062637824  246 TGRGQQGLGISINSNTTISNLLT 268
Cdd:PRK13484   165 TWDGVLGLGGIIQEHGKFGNSTT 187
TonB-siderophor TIGR01783
TonB-dependent siderophore receptor; This subfamily model encompasses a wide variety of ...
 149-251 1.21e-04

TonB-dependent siderophore receptor; This subfamily model encompasses a wide variety of TonB-dependent outer membrane siderophore receptors. It has no overlap with TonB receptors known to transport other substances, but is likely incomplete due to lack of characterizations. It is likely that genuine siderophore receptors will be identified which score below the noise cutoff to this model at which point the model should be updated. [Transport and binding proteins, Cations and iron carrying compounds, Transport and binding proteins, Porins]


Pssm-ID: 273805 [Multi-domain]  Cd Length: 651  Bit Score: 46.25  E-value: 1.21e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  149 KIAGVQTTNSQGDMGSSRIIIRGEtsissqnQPLFVVDGVPVDnsqflgsGGSRDFANTISDINSEDIESISVLKGPNaA 228
Cdd:TIGR01783   28 RVPGVVVGGSGGTTQFGNITIRGF-------GLEVDIDNVYLD-------GVPLLSRGNLAIVDPAMVERVEVLRGPA-S 92

                           90       100
                   ....*....|....*....|...
gi 1062637824  229 ALYGSRAAAGVILIKTKTGRGQQ 251
Cdd:TIGR01783   93 LLYGGSAPGGVINIVTKRPQDEP 115
PRK09840 PRK09840
catecholate siderophore receptor Fiu; Provisional
 676-791 6.11e-04

catecholate siderophore receptor Fiu; Provisional


Pssm-ID: 182105 [Multi-domain]  Cd Length: 761  Bit Score: 44.03  E-value: 6.11e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  676 SFTAPFNGNPQQAAslvelNPNLLPEITKSAEAGIELGLFDNRVKFDLSVYNTNSINQILKVNVSSSTGYNQKLINGGSI 755
Cdd:PRK09840   545 NFALAQSGSGNSAN-----RTDFKPQKANTSEIGTKWQVLDKRLLLTAALFRTDIENEVEQNDDGTYSQYGKKRVEGYEL 619

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1062637824  756 NNKGlevqlGLTPvklqdfSWDINLNYALNRSKVTE 791
Cdd:PRK09840   620 SVAG-----NITP------AWQVIAGYTQQKATVKN 644
PRK13513 PRK13513
ligand-gated channel protein;
104-263 6.71e-04

ligand-gated channel protein;


Pssm-ID: 184104 [Multi-domain]  Cd Length: 659  Bit Score: 43.60  E-value: 6.71e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  104 DLNEVVVTALG----ITKAKKSLGYAVQE-LKSK---DITTAKEtnlinslagKIAGVQTTnsqGDMGSSRIIIRGetsI 175
Cdd:PRK13513    34 PTDTMVVTASGfqqrIQDAPASISVVTREqLENKayrDVTDALK---------DVPGVVVT---GGGSTSDISIRG---M 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  176 SSQnQPLFVVDGVPVD------NSQflGSGGSRDFANTIsdinsEDIESISVLKGPnAAALYGSRAAAGVILIKTKtgRG 249
Cdd:PRK13513    99 AAK-YTLILVDGKRVDtrstrpNSD--GSGIEQGWLPPL-----AAIERIEVVRGP-MSSLYGSDAMGGVINIITR--KV 167

                          170
                   ....*....|....
gi 1062637824  250 QQGLGISINSNTTI 263
Cdd:PRK13513   168 QKEWHGSLRADATL 181
OMP_b-brl_3 pfam14905
Outer membrane protein beta-barrel family; This family includes proteins annotated as TonB ...
 695-782 2.65e-03

Outer membrane protein beta-barrel family; This family includes proteins annotated as TonB dependent receptors. But it is also likely to contain other membrane beta barrel proteins of other functions.


Pssm-ID: 434300 [Multi-domain]  Cd Length: 407  Bit Score: 41.49  E-value: 2.65e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1062637824  695 NPNLLPEITKSAEAGIelgLFDNRVKFDLSVYNTNSINQILKVNVSSSTGYNQKLINGGSINNKGLEVQLGLTPVKLQDF 774
Cdd:pfam14905  209 NPNLKPEYTNSFELGY---TYKWKLSLSLSYRYTNDVIQQTFITDDNDNVTYTTYENLGKSNSYGLELSASFNPTKWWSL 285


                   ....*...
gi 1062637824  775 SWDINLNY 782
Cdd:pfam14905  286 NGNLNGYY 293
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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