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Conserved domains on  [gi|1045263762|gb|ANU48626|]
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hypothetical protein A4V08_25265 [Lachnoclostridium sp. YL32]

Protein Classification

carbohydrate ABC transporter permease( domain architecture ID 10003067)

carbohydrate ABC transporter permease is the transmembrane (TM) subunit of a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter responsible for the translocation across the membrane of one or more from a variety of carbohydrate substrates including trehalose, lactose, arabinose, and maltodextrin

Gene Ontology:  GO:0042626|GO:0140359|GO:0008643|GO:0055085
PubMed:  25750732|24638992|30626703
TCDB:  3.A.1.1.-

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UgpA COG1175
ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];
27-298 6.54e-80

ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];


:

Pssm-ID: 440788 [Multi-domain]  Cd Length: 298  Bit Score: 244.27  E-value: 6.54e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045263762  27 MVPIAAVIFGITGIPFIRALYLSFTN-KVVGVPEQFIGFDNYLALFGDKIYWKCLYNTIIYTVGCITAKLALGLLLAVIL 105
Cdd:COG1175    24 LLPALLLLLVFVLYPLLYTLYLSFTDwNLLGPPPEFVGLDNYARLFTDPRFWNALGNTLLFTVVSVPLQLVLGLLLALLL 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045263762 106 NQKFRGKAFFRTALLIPWALPGMVAATTWRWMYDSTYGIINSLLLKAGLisLPIPWLSAPDITLLSTMLVNVWRGVPFFM 185
Cdd:COG1175   104 NRKLRGRGFFRTLFFLPWVISPVVVALIWKWLFNPDYGLLNALLGALGL--EPINWLGDPSLALPAVIIVTVWKGTGFNM 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045263762 186 FSLLGALQTLDGQIFEAAYVDGAGMFKRFWYITLPGISSVLGISTLLSTIWTFNDFENVFLITGGGPIYSSSVISTYTYD 265
Cdd:COG1175   182 LIFLAGLQSIPRELYEAARIDGASPWQRFRRITLPLLRPTILFVLVLSTIGALQVFDLVYVLTGGGPGNSTTTLVLYIYQ 261

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1045263762 266 LAFIQNSFGRALSVAVSVIPLMVILILVSQKVI 298
Cdd:COG1175   262 TAFQQFDFGYASAIAVVLFLIILVLTLLQLRLL 294
 
Name Accession Description Interval E-value
UgpA COG1175
ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];
27-298 6.54e-80

ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440788 [Multi-domain]  Cd Length: 298  Bit Score: 244.27  E-value: 6.54e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045263762  27 MVPIAAVIFGITGIPFIRALYLSFTN-KVVGVPEQFIGFDNYLALFGDKIYWKCLYNTIIYTVGCITAKLALGLLLAVIL 105
Cdd:COG1175    24 LLPALLLLLVFVLYPLLYTLYLSFTDwNLLGPPPEFVGLDNYARLFTDPRFWNALGNTLLFTVVSVPLQLVLGLLLALLL 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045263762 106 NQKFRGKAFFRTALLIPWALPGMVAATTWRWMYDSTYGIINSLLLKAGLisLPIPWLSAPDITLLSTMLVNVWRGVPFFM 185
Cdd:COG1175   104 NRKLRGRGFFRTLFFLPWVISPVVVALIWKWLFNPDYGLLNALLGALGL--EPINWLGDPSLALPAVIIVTVWKGTGFNM 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045263762 186 FSLLGALQTLDGQIFEAAYVDGAGMFKRFWYITLPGISSVLGISTLLSTIWTFNDFENVFLITGGGPIYSSSVISTYTYD 265
Cdd:COG1175   182 LIFLAGLQSIPRELYEAARIDGASPWQRFRRITLPLLRPTILFVLVLSTIGALQVFDLVYVLTGGGPGNSTTTLVLYIYQ 261

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1045263762 266 LAFIQNSFGRALSVAVSVIPLMVILILVSQKVI 298
Cdd:COG1175   262 TAFQQFDFGYASAIAVVLFLIILVLTLLQLRLL 294
PRK10561 PRK10561
sn-glycerol-3-phosphate ABC transporter permease UgpA;
37-292 4.38e-19

sn-glycerol-3-phosphate ABC transporter permease UgpA;


Pssm-ID: 182550 [Multi-domain]  Cd Length: 280  Bit Score: 84.88  E-value: 4.38e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045263762  37 ITGIPFI----RALYLSFTN-KVVGVPEQFIGFDNYLALFGDKIYWKCLYNTIIYTVGCITAKLALGLLLAVILNQKFRG 111
Cdd:PRK10561    9 ITVIFFIwpagEALWYSLQSvDPFGFSSQFVGLDNFVALFHDSYYLDSFWTTIKFSTLVTVSGLLVSLFFAALVDYVVRG 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045263762 112 KAFFRTALLIPWALPGMVAATTWRWMYDSTYGIINSLLLKAGLislpiPWLSAPDI--TLLSTMLVNVWRGVPFFMFSLL 189
Cdd:PRK10561   89 SRFYQTLMLLPYAVAPAVAAVLWIFLFNPGRGLITHFLAEFGY-----DWNHAQNSgqAMFLVVFASVWKQISYNFLFFF 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045263762 190 GALQTLDGQIFEAAYVDGAGMFKRFWYITLPGISSVLGISTLLSTIWTFND-FENVFLITGGGPIYSSSVISTYTYDLAF 268
Cdd:PRK10561  164 AALQSIPRSLVEAAAIDGAGPIRRFFKLALPLIAPVSFFLLVVNLVYAFFDtFPVIDAATSGGPVQATTTLIYKIYREGF 243

                         250       260
                  ....*....|....*....|....
gi 1045263762 269 iqNSFGRALSVAVSVIPLMVILIL 292
Cdd:PRK10561  244 --TGLDLSSSAAQSVVLMFLVIVL 265
PhnU2 TIGR03262
putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding ...
 50-281 1.91e-07

putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 274495 [Multi-domain]  Cd Length: 546  Bit Score: 51.99  E-value: 1.91e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045263762  50 FTNKVVGVPEQFIGFDNYLALFGDKIYWKCLYNTIiyTVGCITAKLALGLLLA---VILNQKFRGKAFFRTALLIPWALP 126
Cdd:TIGR03262  26 LTKSVYDSDGDFIGLANFAEYFATPGLLQSLGNSL--TVSAIVTAIVVPLAFAfayALTRSRIPGKGAFRLVALLPLLAP 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045263762 127 GMVAATTWRWMYDSTyGIINSLLLKAGLISLPipwlsapditllSTMLVNVWRGVPFFMFSLLGALQTLDGQIFEAAYVD 206
Cdd:TIGR03262 104 SLLPAISLIYLFGNQ-GLLKGLLGGFSIYGFW------------GIVIGEVFYTFPHALMILVTALSLADGRLYEAARAM 170

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1045263762 207 GAGMFKRFWYITLPGISSVLGISTLLSTIWTFNDFeNVFLITGGgpiySSSVISTYTYDLAFIQNSFGRALSVAV 281
Cdd:TIGR03262 171 GASPWRTFFTVTLPGAKYGLISAAFVVFTLVITDF-GVPKVIGG----DYNVLATDIYKQVIGQQNFPMGAVVGV 240
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 153-293 3.70e-06

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 46.52  E-value: 3.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045263762 153 GLISLPIPWLSAPDITLLSTMLVNVWRGVPFFMFSLLGALQTLDGQIFEAAYVDGAGMFKRFWYITLPGISSVLGISTLL 232
Cdd:pfam00528  36 AILLVVIAILSILGHGILPAIILALLGWAGYARLIRRAALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLAL 115

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1045263762 233 STIWTFNDFENVFLITGGGPIYSSSVISTYTYDLAFIQnsfGRALSVAVSVIPLMVILILV 293
Cdd:pfam00528 116 AFGGALGGAVLLEFLGSWPGLGLLLIEAILGYDYPEIQ---GPVLAAALILLLLNLLVDIL 173
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 108-290 7.52e-06

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 45.73  E-value: 7.52e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045263762 108 KFRGKAFFRTALLIPWALPGMVAATTWrwmydstygiinslllkAGLISLPIPWLSAPDITLLSTMLVNVWrGVPFFMFS 187
Cdd:cd06261    30 RGKLDRLLRRIIDLLLSLPSLVLGLLL-----------------VLLFGVLLGWGILPGLGLPALILALLL-IAPFARLI 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045263762 188 LLGALQTLDGQIFEAAYVDGAGMFKRFWYITLPGISSVLGISTLLSTIWTFNDFENVFLITGGGPiyssSVISTYTYDLA 267
Cdd:cd06261    92 RRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEA----PGPGTGLLLIF 167

                         170       180
                  ....*....|....*....|...
gi 1045263762 268 FIQNSFGRALSVAVSVIPLMVIL 290
Cdd:cd06261   168 AILFPGDLGVAAAVALILLLLSL 190
 
Name Accession Description Interval E-value
UgpA COG1175
ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];
27-298 6.54e-80

ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440788 [Multi-domain]  Cd Length: 298  Bit Score: 244.27  E-value: 6.54e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045263762  27 MVPIAAVIFGITGIPFIRALYLSFTN-KVVGVPEQFIGFDNYLALFGDKIYWKCLYNTIIYTVGCITAKLALGLLLAVIL 105
Cdd:COG1175    24 LLPALLLLLVFVLYPLLYTLYLSFTDwNLLGPPPEFVGLDNYARLFTDPRFWNALGNTLLFTVVSVPLQLVLGLLLALLL 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045263762 106 NQKFRGKAFFRTALLIPWALPGMVAATTWRWMYDSTYGIINSLLLKAGLisLPIPWLSAPDITLLSTMLVNVWRGVPFFM 185
Cdd:COG1175   104 NRKLRGRGFFRTLFFLPWVISPVVVALIWKWLFNPDYGLLNALLGALGL--EPINWLGDPSLALPAVIIVTVWKGTGFNM 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045263762 186 FSLLGALQTLDGQIFEAAYVDGAGMFKRFWYITLPGISSVLGISTLLSTIWTFNDFENVFLITGGGPIYSSSVISTYTYD 265
Cdd:COG1175   182 LIFLAGLQSIPRELYEAARIDGASPWQRFRRITLPLLRPTILFVLVLSTIGALQVFDLVYVLTGGGPGNSTTTLVLYIYQ 261

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1045263762 266 LAFIQNSFGRALSVAVSVIPLMVILILVSQKVI 298
Cdd:COG1175   262 TAFQQFDFGYASAIAVVLFLIILVLTLLQLRLL 294
PotB COG1176
ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport ...
 27-302 5.31e-23

ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism];


Pssm-ID: 440789 [Multi-domain]  Cd Length: 287  Bit Score: 95.98  E-value: 5.31e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045263762  27 MVPIAAVIFGITGIPFIRALYLSFTNKV-VGVPEQFIGFDNYLALFGDKIYWKCLYNTIIY----TVGC----------I 91
Cdd:COG1176    15 LLPALLWLLLFFVLPLLLLLVYSFTTRDpYGGVVPGFTLENYARLFTDPLYLKVLLRTLWIalltTLIClllgypiayfL 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045263762  92 TAKlalglllavilnqKFRGKAFFRTALLIPWALPGMVAATTWRWMYdSTYGIINSLLLKAGLISLPIPWLSapdiTLLS 171
Cdd:COG1176    95 ARA-------------PPRWRNLLLLLVILPFWTSFLVRTYAWIVLL-GRNGLLNSLLLALGLIDEPLRLLY----TEFA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045263762 172 TMLVNVWRGVPFFMFSLLGALQTLDGQIFEAAYVDGAGMFKRFWYITLPGISSVLGISTLLSTIWTFNDFENVFLItgGG 251
Cdd:COG1176   157 VVIGLVYVYLPFMVLPLYAALEKIDPSLLEAARDLGASPWQTFRRVILPLSLPGIIAGSLLVFIPALGAFVTPALL--GG 234

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1045263762 252 PiySSSVISTYTYDLAFIQNSFGRALSVAVSVIPLMVILILVSQKVISGDG 302
Cdd:COG1176   235 G--KVLMIGNLIYQQFLSALNWPLAAALAVVLLLIVLLVLLLYLRLLRRRR 283
LplB COG4209
ABC-type polysaccharide transport system, permease component [Carbohydrate transport and ...
 60-303 1.22e-22

ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 443357 [Multi-domain]  Cd Length: 316  Bit Score: 95.54  E-value: 1.22e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045263762  60 QFIGFDNYLALFGDKIYWKCLYNTIIYTVGCITAKLALGLLLAVILNQ--KFRGKAFFRTALLIPWALPGMVAATTWRWM 137
Cdd:COG4209    68 PWVGLKNFKFLFSSPDFWRVLRNTLLISLLKLVFGFPLPIILALLLNElrSKRFKKTVQTISYLPHFLSWVVVAGIVYQF 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045263762 138 YDSTYGIINSLLLKAGLisLPIPWLSAPDITLLSTMLVNVWRGVPFFMFSLLGALQTLDGQIFEAAYVDGAGMFKRFWYI 217
Cdd:COG4209   148 LSPDTGLVNQLLRALGG--EPINFLTEPKYFRPIYVFSGIWKEAGWGSIIYLAAITGIDPELYEAAAIDGAGRWQQIWHI 225

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045263762 218 TLPGISSVLGISTLLSTIWTFN-DFENVFLItGGGPIYSSS-VISTYTYDLAFIQNSFGraLSVAV----SVIPLmvILI 291
Cdd:COG4209   226 TLPGIRPTIVILLILNIGNILNvGFEQIYLL-YNPLNYSTSdVIDTYVYRIGLQNGDYS--YATAVglfkSVVGL--ILV 300

                         250
                  ....*....|....*
gi 1045263762 292 LVSQKV---ISGDGI 303
Cdd:COG4209   301 LIANKIakkLGEESL 315
PRK10561 PRK10561
sn-glycerol-3-phosphate ABC transporter permease UgpA;
37-292 4.38e-19

sn-glycerol-3-phosphate ABC transporter permease UgpA;


Pssm-ID: 182550 [Multi-domain]  Cd Length: 280  Bit Score: 84.88  E-value: 4.38e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045263762  37 ITGIPFI----RALYLSFTN-KVVGVPEQFIGFDNYLALFGDKIYWKCLYNTIIYTVGCITAKLALGLLLAVILNQKFRG 111
Cdd:PRK10561    9 ITVIFFIwpagEALWYSLQSvDPFGFSSQFVGLDNFVALFHDSYYLDSFWTTIKFSTLVTVSGLLVSLFFAALVDYVVRG 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045263762 112 KAFFRTALLIPWALPGMVAATTWRWMYDSTYGIINSLLLKAGLislpiPWLSAPDI--TLLSTMLVNVWRGVPFFMFSLL 189
Cdd:PRK10561   89 SRFYQTLMLLPYAVAPAVAAVLWIFLFNPGRGLITHFLAEFGY-----DWNHAQNSgqAMFLVVFASVWKQISYNFLFFF 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045263762 190 GALQTLDGQIFEAAYVDGAGMFKRFWYITLPGISSVLGISTLLSTIWTFND-FENVFLITGGGPIYSSSVISTYTYDLAF 268
Cdd:PRK10561  164 AALQSIPRSLVEAAAIDGAGPIRRFFKLALPLIAPVSFFLLVVNLVYAFFDtFPVIDAATSGGPVQATTTLIYKIYREGF 243

                         250       260
                  ....*....|....*....|....
gi 1045263762 269 iqNSFGRALSVAVSVIPLMVILIL 292
Cdd:PRK10561  244 --TGLDLSSSAAQSVVLMFLVIVL 265
malF PRK10999
maltose ABC transporter permease MalF;
110-294 3.24e-18

maltose ABC transporter permease MalF;


Pssm-ID: 236816 [Multi-domain]  Cd Length: 520  Bit Score: 84.63  E-value: 3.24e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045263762 110 RGKAFFRTALLIPWALPGMVAATTWRWMYDSTYGIINSLLlkAGLISLPIPWLSAPdiTLLSTML--VNVWRGVPFFMFS 187
Cdd:PRK10999  318 KGKAVYRVLLILPYAVPSFISILIFKGLFNQSFGEINMML--SALFGIKPAWFSDP--TLAKTMIliVNTWLGYPYMMIL 393

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045263762 188 LLGALQTLDGQIFEAAYVDGAGMFKRFWYITLPGISSVLGISTLLSTIWTFNDFENVFLITGGGP--IYSSSV------I 259
Cdd:PRK10999  394 CMGLLKAIPDDLYEASAMDGAGPFQNFFKITLPLLIKPLTPLMIASFAFNFNNFVLIQLLTNGGPdmIGTTTPagytdlL 473

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1045263762 260 STYTYDLAF----IQNsFGRALSVAVsviplmVILILVS 294
Cdd:PRK10999  474 VSYTYRIAFegggGQD-FGLAAAIAT------LIFLLVG 505
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
30-300 4.88e-18

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 84.06  E-value: 4.88e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045263762  30 IAAVIFGITGIPFIRALYLSFTNkvvgvpeqfiGFDNYLALFGDKIYWKCLYNTIIYTVG-CITAKLALGLLLAVILNQK 108
Cdd:COG1178    16 LALLLALLVLLPLLALLLRAFTD----------GLANFWALLSDPYLWRALGNTLLLALLvTLLSLLLGVPLAWLLARTD 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045263762 109 FRGKAFFRTALLIPWALPGMVAATTWRWMYDSTyGIINSLLLKAGLISLPipwlsapDI-TLLSTMLVNVWRGVPFFMFS 187
Cdd:COG1178    86 FPGRRLLRWLLLLPLALPPYVVALAWIALFGPN-GLLNTLLRALFGLEPP-------DIyGLGGIILVLVLFNYPYVYLL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045263762 188 LLGALQTLDGQIFEAAYVDGAGMFKRFWYITLPGISSVLGISTLLSTIWTFNDFENVFLItgGGPIyssSVISTYTYDLA 267
Cdd:COG1178   158 LRAALRSIDASLEEAARSLGASPWRAFRRVTLPLLRPAIAAGALLVFLLCLADFGTPLVL--GGGY---TTLTTAIYQAW 232

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1045263762 268 FIQNSFGRALSVAVSVIPLMVILILVSQKVISG 300
Cdd:COG1178   233 LGDFDLGAAAALALVLLLLVLLLLLLERRLRRR 265
UgpE COG0395
ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and ...
 30-300 2.04e-12

ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440164 [Multi-domain]  Cd Length: 282  Bit Score: 66.27  E-value: 2.04e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045263762  30 IAAVIFGITGIPFIRALYLSF-------TNKVVGVPEQFiGFDNYLALFGDKIYWKCLYNTIIYTVGCITAKLALGLLLA 102
Cdd:COG0395    20 LLILLALLFLFPLYWMVVTSFkppaeifSGPPSLLPSEF-TLENYRAAFTDGPFGRYLLNSLIVAVVSTVLSLLLSSLAA 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045263762 103 VILNQ-KFRGKAFFRTALLIPWALPGMVAATTWRWMYdSTYGIINSLLlkaGLIslpIPWLSApditllstmlvnvwrGV 181
Cdd:COG0395    99 YALARfRFRGRKLLFLLILATLMIPGQVLLIPLYLLF-RQLGLLNTYW---GLI---LPYLAF---------------GL 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045263762 182 PFFMFSLLGALQTLDGQIFEAAYVDGAGMFKRFWYITLPGISSVLGISTLLSTIWTFNDFENVFLITgggpiySSSVIST 261
Cdd:COG0395   157 PFGIFLLRQFFRSIPRELEEAARIDGASEFRIFWRIVLPLSKPALATVAIFTFIGAWNDFLWPLILL------TSPDLRT 230

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1045263762 262 YTYDLAFIQNSFGRALSV-----AVSVIPLMVILILVSQKVISG 300
Cdd:COG0395   231 LPVGLASFQGQYGTDWGLlmaaaVIATLPVLILFLFLQRYFVRG 274
PotC COG1177
ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport ...
 30-298 5.81e-11

ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism];


Pssm-ID: 440790 [Multi-domain]  Cd Length: 262  Bit Score: 61.67  E-value: 5.81e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045263762  30 IAAVIFGITGIPFIRALYLSFTNK--VVGVPEQFiGFDNYLALFGDKIYWKCLYNTIIytVGCITAKLALG---LLLAVI 104
Cdd:COG1177    12 FLALVLLFLYLPILVLVLYSFNDSwfLTFPPEGF-TLRWYAELFSDPRLLDALLNSLL--IALLSTLLATVlgtPAALAL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045263762 105 LNQKFRGKAFFRTALLIPWALPGMVAATtwrwmydstygiinSLLLKAGLISLPIpwlsapdiTLLSTMLVNVWRGVPFF 184
Cdd:COG1177    89 ARYRFRGRRLLLALLLLPLVVPGIVLGV--------------ALLLLFSALGLSG--------GLWGLILAHVVFTLPFV 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045263762 185 MFSLLGALQTLDGQIFEAAYVDGAGMFKRFWYITLPGISSVLGISTLLSTIWTFNDFENVFLITGGGpiysSSVISTYTY 264
Cdd:COG1177   147 VLVVLARLQGFDPSLEEAARDLGASPWQTFRRVTLPLIAPGILAGALLAFTLSFDEFVITLFLAGPG----VTTLPVYIY 222

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1045263762 265 DLAFIQNSFgRALSVAVSVIPLMVILILVSQKVI 298
Cdd:COG1177   223 SMIRRGISP-EINALSTLLILLSLLLLLLAERLR 255
PhnU2 TIGR03262
putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding ...
 50-281 1.91e-07

putative 2-aminoethylphosphonate ABC transporter, permease protein; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 274495 [Multi-domain]  Cd Length: 546  Bit Score: 51.99  E-value: 1.91e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045263762  50 FTNKVVGVPEQFIGFDNYLALFGDKIYWKCLYNTIiyTVGCITAKLALGLLLA---VILNQKFRGKAFFRTALLIPWALP 126
Cdd:TIGR03262  26 LTKSVYDSDGDFIGLANFAEYFATPGLLQSLGNSL--TVSAIVTAIVVPLAFAfayALTRSRIPGKGAFRLVALLPLLAP 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045263762 127 GMVAATTWRWMYDSTyGIINSLLLKAGLISLPipwlsapditllSTMLVNVWRGVPFFMFSLLGALQTLDGQIFEAAYVD 206
Cdd:TIGR03262 104 SLLPAISLIYLFGNQ-GLLKGLLGGFSIYGFW------------GIVIGEVFYTFPHALMILVTALSLADGRLYEAARAM 170

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1045263762 207 GAGMFKRFWYITLPGISSVLGISTLLSTIWTFNDFeNVFLITGGgpiySSSVISTYTYDLAFIQNSFGRALSVAV 281
Cdd:TIGR03262 171 GASPWRTFFTVTLPGAKYGLISAAFVVFTLVITDF-GVPKVIGG----DYNVLATDIYKQVIGQQNFPMGAVVGV 240
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
30-296 2.06e-07

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 52.09  E-value: 2.06e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045263762  30 IAAVIFGITGIPFIRALYLSFTnkvvGVPEQFIGFDNYLALFGDKIYWKCLYNTIIYTVGCITAKLALGLLLAVILN-QK 108
Cdd:COG1178   294 CLLLVLLGLLLPLLALLLWSLT----KALDDNLTLDNYRFVLLDPSLLRALLNSLLLALLAALLAVLLALLLAYLVRrRR 369

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045263762 109 FRGKAFFRTALLIPWALPGMVAATtwrwmydstygiinSLLLkaGLISLPIPWLSApdiTLLSTMLVNVWRGVPFFMFSL 188
Cdd:COG1178   370 GRLARLLDRLAMLPYAVPGIVLGL--------------GLLL--LFNRPLPLLLYG---TLAILVLAYVVRFLPFALRSL 430

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045263762 189 LGALQTLDGQIFEAAYVDGAGMFKRFWYITLPGISSVLGISTLLSTIWTFNDFENVFLITGGGpiysSSVISTYTYDLAf 268
Cdd:COG1178   431 EAALAQIDPSLEEAARSLGASPLRTLRRVTLPLLRPGLLAAALLVFVTSMKELSATLLLRPPG----FETLAVLIYQLA- 505

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1045263762 269 IQNSFGRA-----LSVAVSVIPLMVILILVSQK 296
Cdd:COG1178   506 SSGRYGEAaalalLLVLVSLLPVLLLERLLGRR 538
MalG COG3833
ABC-type maltose transport system, permease component MalG [Carbohydrate transport and ...
 57-241 8.06e-07

ABC-type maltose transport system, permease component MalG [Carbohydrate transport and metabolism];


Pssm-ID: 443045 [Multi-domain]  Cd Length: 282  Bit Score: 49.38  E-value: 8.06e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045263762  57 VPEQFiGFDNYLALFGDKIYWKCLYNT-IIYTVGCITAKLALGLLLAVILNQKFRGKAFFRTALLIPWALPGMVAATTwr 135
Cdd:COG3833    53 IPENF-TLENYKKLFTETPFLRWFLNSlIVAVVTAIISVFLAALAAYAFSRFRFKGRKAGLLALLLLQMFPAFLALVA-- 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045263762 136 wmydstygiINSLLLKAGLISlpipwlsapdiTLLSTMLVNVWRGVPFFMFSLLGALQTLDGQIFEAAYVDGAGMFKRFW 215
Cdd:COG3833   130 ---------LYLLLSALGLLN-----------TLLGLILVYLGGAIPFNTWLMKGYFDTIPKELDEAAKIDGASHFQIFF 189

                         170       180
                  ....*....|....*....|....*.
gi 1045263762 216 YITLPGISSVLGISTLLSTIWTFNDF 241
Cdd:COG3833   190 RIILPLAKPILAVVALLSFIGPWNDF 215
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 153-293 3.70e-06

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 46.52  E-value: 3.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045263762 153 GLISLPIPWLSAPDITLLSTMLVNVWRGVPFFMFSLLGALQTLDGQIFEAAYVDGAGMFKRFWYITLPGISSVLGISTLL 232
Cdd:pfam00528  36 AILLVVIAILSILGHGILPAIILALLGWAGYARLIRRAALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLAL 115

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1045263762 233 STIWTFNDFENVFLITGGGPIYSSSVISTYTYDLAFIQnsfGRALSVAVSVIPLMVILILV 293
Cdd:pfam00528 116 AFGGALGGAVLLEFLGSWPGLGLLLIEAILGYDYPEIQ---GPVLAAALILLLLNLLVDIL 173
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 108-290 7.52e-06

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 45.73  E-value: 7.52e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045263762 108 KFRGKAFFRTALLIPWALPGMVAATTWrwmydstygiinslllkAGLISLPIPWLSAPDITLLSTMLVNVWrGVPFFMFS 187
Cdd:cd06261    30 RGKLDRLLRRIIDLLLSLPSLVLGLLL-----------------VLLFGVLLGWGILPGLGLPALILALLL-IAPFARLI 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045263762 188 LLGALQTLDGQIFEAAYVDGAGMFKRFWYITLPGISSVLGISTLLSTIWTFNDFENVFLITGGGPiyssSVISTYTYDLA 267
Cdd:cd06261    92 RRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEA----PGPGTGLLLIF 167

                         170       180
                  ....*....|....*....|...
gi 1045263762 268 FIQNSFGRALSVAVSVIPLMVIL 290
Cdd:cd06261   168 AILFPGDLGVAAAVALILLLLSL 190
CysU COG0555
ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism]; ...
 109-220 1.29e-05

ABC-type sulfate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440321 [Multi-domain]  Cd Length: 268  Bit Score: 45.90  E-value: 1.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045263762 109 FRGKAFFRTALLIPWALPGMVAATTWRWMYdSTYGIINSLLLKAGLislpipwlsapDI--TLLSTMLVNVWRGVPFFMF 186
Cdd:COG0555    86 FPGKRLVDALVDLPFALPTAVAGIALLLLF-GPNGWLGQLLAPLGI-----------KVafTPLGIVLAQTFVSLPFVVR 153

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1045263762 187 SLLGALQTLDGQIFEAAYVDGAGMFKRFWYITLP 220
Cdd:COG0555   154 TVQPVLEELDPELEEAAATLGASRWQTFRRVILP 187
potB PRK09497
spermidine/putrescine ABC transporter membrane protein; Reviewed
 64-220 1.39e-04

spermidine/putrescine ABC transporter membrane protein; Reviewed


Pssm-ID: 181910  Cd Length: 285  Bit Score: 42.75  E-value: 1.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045263762  64 FDNYLALFGD---KIYWKCLYNTIIYTVGCItAKLALGLLLAVILNQKFRgkAFFRTALLIPWALPGMVAATTWRwMYDS 140
Cdd:PRK09497   50 LDNYTRLLDPlyaEVLLHSLNMALIATLACL-VLGYPFAWFLAKLPHKVR--PLLLFLLIVPFWTNSLIRIYGLK-IFLS 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1045263762 141 TYGIINSLLLKAGLISLPIPWLSAPditlLSTMLVNVWRGVPFFMFSLLGALQTLDGQIFEAAYVDGAGMFKRFWYITLP 220
Cdd:PRK09497  126 TKGYLNEFLLWLGVIDTPIRIMFTE----SAVIIGLVYILLPFMVLPLYSSIEKLDKPLLEAARDLGANKLQTFIRIIIP 201
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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