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Conserved domains on  [gi|1026943992|gb|AND76663|]
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fibroblast activation protein, partial [Homo sapiens]

Protein Classification

S9 family peptidase( domain architecture ID 12012129)

peptidase S9 family protein, an oligopeptidase which may cleave the prolyl bond of short peptides, similar to oligopeptidase B, which cleaves on the C-terminal side of lysyl and argininyl residues

CATH:  3.40.50.1820|2.140.10.30
EC:  3.4.-.-
Gene Ontology:  GO:0008236|GO:0006508
MEROPS:  S9
PubMed:  19508187|12369917|35631755
SCOP:  3000102

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DPPIV_N pfam00930
Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region ...
 79-446 1.95e-119

Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region to the N-terminal side of the active site. The Prosite motif does not correspond to this Pfam entry.


:

Pssm-ID: 395744 [Multi-domain]  Cd Length: 352  Bit Score: 362.02  E-value: 1.95e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026943992  79 SPDRQFVYLESDYSKLWRYSYTATYYIYDLSNGEFVRGNELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPPFQITF 158
Cdd:pfam00930   1 SPDGKYLLLATNYTKNWRHSYTADYYIYDLETNRVEPLPPGEGKIQDAKWSPDGDRLAFVRDNNLYVRELATGKEIQITS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026943992 159 NGrENKIFNGIPDWVYEEEMLPTKYALWWSPNGKFLAYAEFNDKDIPVIAYSYYGDEQ-YPRTINIPYPKAGAKNPVVRI 237
Cdd:pfam00930  81 DG-SDGIFNGVADWVYEEEVLGSNSAVWWSPDGSRLAFLRFDESEVPIITLPYYTDEGpGPEVREIKYPKAGAPNPTVEL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026943992 238 FIIDTTYPAYVgpqEVPVPAMIASSDYYFSWLTWVTDERVCLQWLKRVQNVSVLSICDFREDWQTWDCpktqehiEESRT 317
Cdd:pfam00930 160 FVYDLASGKTV---EVVPPDDLSDADYYITRVKWVPDGKLLVQWLNRDQNRLKVVLCDAETGRTVVIL-------EETSD 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026943992 318 GWAgGFFVSRPVFSYDAISYYKIfSDKDGYKHIHYIKDTVENAIQITSGKWEAINIFRV--TQDSLFYSSNefEEYPGRR 395
Cdd:pfam00930 230 GWV-ELHQDPHFIKRDGSGFLWI-SERDGYNHLYLYDLDGKSPIQLTSGNWEVTSILGVdeTRDLVYFTAT--EDSPTER 305

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1026943992 396 NIYRISIGSyPPSKKCVTCHLRKErcqYYTASFSDYAKYYALVCYGPGIPI 446
Cdd:pfam00930 306 HLYSVSLDS-GGEPTCLTDDSGDH---DYSASFSPNGSYYVLTYSGPDTPP 352
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
526-729 1.25e-64

Prolyl oligopeptidase family;


:

Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 213.63  E-value: 1.25e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026943992 526 FAVNWISYLASKEGMVIALVDGRGTAFQGDKLLYAVYRKLGVYEVEDQITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSL 605
Cdd:pfam00326   1 PSFSWNAQLLADRGYVVAIANGRGSGGYGEAFHDAGKGDLGQNEFDDFIAAAEYLIEQGYTDPDRLAIWGGSYGGYLTGA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026943992 606 ALASGTGLFKCGIAVAPVSSWEYYAS----VYTERFMGLPTKDDNLEHYK-NSTVMARAEYFRNVDYLLIHGTADDNVHF 680
Cdd:pfam00326  81 ALNQRPDLFKAAVAHVPVVDWLAYMSdtslPFTERYMEWGNPWDNEEGYDyLSPYSPADNVKVYPPLLLIHGLLDDRVPP 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1026943992 681 QNSAQIAKALVNAQVDFQAMWYSDQNHG-LSGLSTNHLYTHMTHFLKQCF 729
Cdd:pfam00326 161 WQSLKLVAALQRKGVPFLLLIFPDEGHGiGKPRNKVEEYARELAFLLEYL 210
 
Name Accession Description Interval E-value
DPPIV_N pfam00930
Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region ...
 79-446 1.95e-119

Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region to the N-terminal side of the active site. The Prosite motif does not correspond to this Pfam entry.


Pssm-ID: 395744 [Multi-domain]  Cd Length: 352  Bit Score: 362.02  E-value: 1.95e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026943992  79 SPDRQFVYLESDYSKLWRYSYTATYYIYDLSNGEFVRGNELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPPFQITF 158
Cdd:pfam00930   1 SPDGKYLLLATNYTKNWRHSYTADYYIYDLETNRVEPLPPGEGKIQDAKWSPDGDRLAFVRDNNLYVRELATGKEIQITS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026943992 159 NGrENKIFNGIPDWVYEEEMLPTKYALWWSPNGKFLAYAEFNDKDIPVIAYSYYGDEQ-YPRTINIPYPKAGAKNPVVRI 237
Cdd:pfam00930  81 DG-SDGIFNGVADWVYEEEVLGSNSAVWWSPDGSRLAFLRFDESEVPIITLPYYTDEGpGPEVREIKYPKAGAPNPTVEL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026943992 238 FIIDTTYPAYVgpqEVPVPAMIASSDYYFSWLTWVTDERVCLQWLKRVQNVSVLSICDFREDWQTWDCpktqehiEESRT 317
Cdd:pfam00930 160 FVYDLASGKTV---EVVPPDDLSDADYYITRVKWVPDGKLLVQWLNRDQNRLKVVLCDAETGRTVVIL-------EETSD 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026943992 318 GWAgGFFVSRPVFSYDAISYYKIfSDKDGYKHIHYIKDTVENAIQITSGKWEAINIFRV--TQDSLFYSSNefEEYPGRR 395
Cdd:pfam00930 230 GWV-ELHQDPHFIKRDGSGFLWI-SERDGYNHLYLYDLDGKSPIQLTSGNWEVTSILGVdeTRDLVYFTAT--EDSPTER 305

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1026943992 396 NIYRISIGSyPPSKKCVTCHLRKErcqYYTASFSDYAKYYALVCYGPGIPI 446
Cdd:pfam00930 306 HLYSVSLDS-GGEPTCLTDDSGDH---DYSASFSPNGSYYVLTYSGPDTPP 352
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
526-729 1.25e-64

Prolyl oligopeptidase family;


Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 213.63  E-value: 1.25e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026943992 526 FAVNWISYLASKEGMVIALVDGRGTAFQGDKLLYAVYRKLGVYEVEDQITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSL 605
Cdd:pfam00326   1 PSFSWNAQLLADRGYVVAIANGRGSGGYGEAFHDAGKGDLGQNEFDDFIAAAEYLIEQGYTDPDRLAIWGGSYGGYLTGA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026943992 606 ALASGTGLFKCGIAVAPVSSWEYYAS----VYTERFMGLPTKDDNLEHYK-NSTVMARAEYFRNVDYLLIHGTADDNVHF 680
Cdd:pfam00326  81 ALNQRPDLFKAAVAHVPVVDWLAYMSdtslPFTERYMEWGNPWDNEEGYDyLSPYSPADNVKVYPPLLLIHGLLDDRVPP 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1026943992 681 QNSAQIAKALVNAQVDFQAMWYSDQNHG-LSGLSTNHLYTHMTHFLKQCF 729
Cdd:pfam00326 161 WQSLKLVAALQRKGVPFLLLIFPDEGHGiGKPRNKVEEYARELAFLLEYL 210
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
487-729 9.04e-53

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 182.52  E-value: 9.04e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026943992 487 DEITLWYKMILPPQfdrSKKYPLLIQVYGGPCSQSVRSVFavnWISYLASKeGMVIALVDGRGtafQGDKLlyavyRKLG 566
Cdd:COG1506     6 DGTTLPGWLYLPAD---GKKYPVVVYVHGGPGSRDDSFLP---LAQALASR-GYAVLAPDYRG---YGESA-----GDWG 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026943992 567 VYEVEDQITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASV---YTERFMGLPtk 643
Cdd:COG1506    71 GDEVDDVLAAIDYLAARPYVDPDRIGIYGHSYGGYMALLAAARHPDRFKAAVALAGVSDLRSYYGTtreYTERLMGGP-- 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026943992 644 DDNLEHYKNSTVMARAEYFRnVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYSDQNHGLSGLSTNHLYTHMTH 723
Cdd:COG1506   149 WEDPEAYAARSPLAYADKLK-TPLLLIHGEADDRVPPEQAERLYEALKKAGKPVELLVYPGEGHGFSGAGAPDYLERILD 227


                  ....*.
gi 1026943992 724 FLKQCF 729
Cdd:COG1506   228 FLDRHL 233
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 104-201 4.09e-06

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 47.36  E-value: 4.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026943992 104 YIYDLSNGEFVRGNELPRPIQYLCWSPVGSKLAYV----YQNNIYLKQRPGDPPFQITFNGRENkifngipdwvyeeeml 179
Cdd:COG0823    14 YVVDLDGGEPRRLTNSPGIDTSPAWSPDGRRIAFTsdrgGGPQIYVVDADGGEPRRLTFGGGYN---------------- 77

                          90       100
                  ....*....|....*....|..
gi 1026943992 180 ptkYALWWSPNGKFLAYAEFND 201
Cdd:COG0823    78 ---ASPSWSPDGKRLAFVSRSD 96
 
Name Accession Description Interval E-value
DPPIV_N pfam00930
Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region ...
 79-446 1.95e-119

Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region to the N-terminal side of the active site. The Prosite motif does not correspond to this Pfam entry.


Pssm-ID: 395744 [Multi-domain]  Cd Length: 352  Bit Score: 362.02  E-value: 1.95e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026943992  79 SPDRQFVYLESDYSKLWRYSYTATYYIYDLSNGEFVRGNELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPPFQITF 158
Cdd:pfam00930   1 SPDGKYLLLATNYTKNWRHSYTADYYIYDLETNRVEPLPPGEGKIQDAKWSPDGDRLAFVRDNNLYVRELATGKEIQITS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026943992 159 NGrENKIFNGIPDWVYEEEMLPTKYALWWSPNGKFLAYAEFNDKDIPVIAYSYYGDEQ-YPRTINIPYPKAGAKNPVVRI 237
Cdd:pfam00930  81 DG-SDGIFNGVADWVYEEEVLGSNSAVWWSPDGSRLAFLRFDESEVPIITLPYYTDEGpGPEVREIKYPKAGAPNPTVEL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026943992 238 FIIDTTYPAYVgpqEVPVPAMIASSDYYFSWLTWVTDERVCLQWLKRVQNVSVLSICDFREDWQTWDCpktqehiEESRT 317
Cdd:pfam00930 160 FVYDLASGKTV---EVVPPDDLSDADYYITRVKWVPDGKLLVQWLNRDQNRLKVVLCDAETGRTVVIL-------EETSD 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026943992 318 GWAgGFFVSRPVFSYDAISYYKIfSDKDGYKHIHYIKDTVENAIQITSGKWEAINIFRV--TQDSLFYSSNefEEYPGRR 395
Cdd:pfam00930 230 GWV-ELHQDPHFIKRDGSGFLWI-SERDGYNHLYLYDLDGKSPIQLTSGNWEVTSILGVdeTRDLVYFTAT--EDSPTER 305

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1026943992 396 NIYRISIGSyPPSKKCVTCHLRKErcqYYTASFSDYAKYYALVCYGPGIPI 446
Cdd:pfam00930 306 HLYSVSLDS-GGEPTCLTDDSGDH---DYSASFSPNGSYYVLTYSGPDTPP 352
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
526-729 1.25e-64

Prolyl oligopeptidase family;


Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 213.63  E-value: 1.25e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026943992 526 FAVNWISYLASKEGMVIALVDGRGTAFQGDKLLYAVYRKLGVYEVEDQITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSL 605
Cdd:pfam00326   1 PSFSWNAQLLADRGYVVAIANGRGSGGYGEAFHDAGKGDLGQNEFDDFIAAAEYLIEQGYTDPDRLAIWGGSYGGYLTGA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026943992 606 ALASGTGLFKCGIAVAPVSSWEYYAS----VYTERFMGLPTKDDNLEHYK-NSTVMARAEYFRNVDYLLIHGTADDNVHF 680
Cdd:pfam00326  81 ALNQRPDLFKAAVAHVPVVDWLAYMSdtslPFTERYMEWGNPWDNEEGYDyLSPYSPADNVKVYPPLLLIHGLLDDRVPP 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1026943992 681 QNSAQIAKALVNAQVDFQAMWYSDQNHG-LSGLSTNHLYTHMTHFLKQCF 729
Cdd:pfam00326 161 WQSLKLVAALQRKGVPFLLLIFPDEGHGiGKPRNKVEEYARELAFLLEYL 210
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
487-729 9.04e-53

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 182.52  E-value: 9.04e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026943992 487 DEITLWYKMILPPQfdrSKKYPLLIQVYGGPCSQSVRSVFavnWISYLASKeGMVIALVDGRGtafQGDKLlyavyRKLG 566
Cdd:COG1506     6 DGTTLPGWLYLPAD---GKKYPVVVYVHGGPGSRDDSFLP---LAQALASR-GYAVLAPDYRG---YGESA-----GDWG 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026943992 567 VYEVEDQITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASV---YTERFMGLPtk 643
Cdd:COG1506    71 GDEVDDVLAAIDYLAARPYVDPDRIGIYGHSYGGYMALLAAARHPDRFKAAVALAGVSDLRSYYGTtreYTERLMGGP-- 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026943992 644 DDNLEHYKNSTVMARAEYFRnVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYSDQNHGLSGLSTNHLYTHMTH 723
Cdd:COG1506   149 WEDPEAYAARSPLAYADKLK-TPLLLIHGEADDRVPPEQAERLYEALKKAGKPVELLVYPGEGHGFSGAGAPDYLERILD 227


                  ....*.
gi 1026943992 724 FLKQCF 729
Cdd:COG1506   228 FLDRHL 233
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
534-708 2.13e-07

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 52.28  E-value: 2.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026943992 534 LAsKEGMVIALVD--GRGTAFQGDKLLYAVYRKLGVYEVEDQITAVRKFI-EMGFIDEKRIAIWGWSYGGYVsSLALASG 610
Cdd:COG0412    52 LA-AAGYVVLAPDlyGRGGPGDDPDEARALMGALDPELLAADLRAALDWLkAQPEVDAGRVGVVGFCFGGGL-ALLAAAR 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026943992 611 TGLFKCGIAvapvssweyyasvyterFMGLPTKDDNLEHYKNSTvmaraeyfrnVDYLLIHGTADDNVHFQNSAQIAKAL 690
Cdd:COG0412   130 GPDLAAAVS-----------------FYGGLPADDLLDLAARIK----------APVLLLYGEKDPLVPPEQVAALEAAL 182

                         170
                  ....*....|....*...
gi 1026943992 691 VNAQVDFQAMWYSDQNHG 708
Cdd:COG0412   183 AAAGVDVELHVYPGAGHG 200
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 487-689 2.47e-07

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 52.61  E-value: 2.47e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026943992 487 DEITL---WYkmiLPPqfDRSKKYPLLIQVYGGPCSQSVRSVFAvnwiSYLAsKEGMVIALVDGRGT-AFQGDkllyavY 562
Cdd:COG1073    19 DGIKLagdLY---LPA--GASKKYPAVVVAHGNGGVKEQRALYA----QRLA-ELGFNVLAFDYRGYgESEGE------P 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026943992 563 RKLGVYEVEDQITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSLALASGTGlFKCGIAVAPVSSWEYYASVYTERFMGLPT 642
Cdd:COG1073    83 REEGSPERRDARAAVDYLRTLPGVDPERIGLLGISLGGGYALNAAATDPR-VKAVILDSPFTSLEDLAAQRAKEARGAYL 161

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1026943992 643 KDDNLeHYKNSTVMARAEYFRNVDY--------LLIHGTADDNVHFQNSAQIAKA 689
Cdd:COG1073   162 PGVPY-LPNVRLASLLNDEFDPLAKiekisrplLFIHGEKDEAVPFYMSEDLYEA 215
LpqC COG3509
Acetyl xylan esterase AxeA and related esterases, LpqC family [Carbohydrate transport and ...
 484-693 1.52e-06

Acetyl xylan esterase AxeA and related esterases, LpqC family [Carbohydrate transport and metabolism];


Pssm-ID: 442732 [Multi-domain]  Cd Length: 284  Bit Score: 50.39  E-value: 1.52e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026943992 484 LEVDEITLWYKMILPPQFDRSKKYPLLIQVYGgpCSQSVRSVFAV-NWISyLASKEGMVIALVDGRGTA-------FQGD 555
Cdd:COG3509    30 FTVGGGTRTYRLYVPAGYDGGAPLPLVVALHG--CGGSAADFAAGtGLNA-LADREGFIVVYPEGTGRApgrcwnwFDGR 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026943992 556 KllyavyRKLGVYEVEDQITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSLALASGTGLFKcgiAVAPVSsweyyasvyte 635
Cdd:COG3509   107 D------QRRGRDDVAFIAALVDDLAARYGIDPKRVYVTGLSAGGAMAYRLACEYPDVFA---AVAPVA----------- 166

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1026943992 636 rfmGLPTKDDNlehyknstvMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNA 693
Cdd:COG3509   167 ---GLPYGAAS---------DAACAPGRPVPVLVIHGTADPTVPYAGAEETLAQWAAL 212
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 104-201 4.09e-06

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 47.36  E-value: 4.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026943992 104 YIYDLSNGEFVRGNELPRPIQYLCWSPVGSKLAYV----YQNNIYLKQRPGDPPFQITFNGRENkifngipdwvyeeeml 179
Cdd:COG0823    14 YVVDLDGGEPRRLTNSPGIDTSPAWSPDGRRIAFTsdrgGGPQIYVVDADGGEPRRLTFGGGYN---------------- 77

                          90       100
                  ....*....|....*....|..
gi 1026943992 180 ptkYALWWSPNGKFLAYAEFND 201
Cdd:COG0823    78 ---ASPSWSPDGKRLAFVSRSD 96
Aes COG0657
Acetyl esterase/lipase [Lipid transport and metabolism];
502-730 3.69e-05

Acetyl esterase/lipase [Lipid transport and metabolism];


Pssm-ID: 440422 [Multi-domain]  Cd Length: 207  Bit Score: 45.25  E-value: 3.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026943992 502 DRSKKYPLLIQVYGG-PCSQSVRSVFAVnwISYLASKEGMVIALVDgrgtafqgdkllyavYRKL-------GVYEVEDQ 573
Cdd:COG0657     8 GAKGPLPVVVYFHGGgWVSGSKDTHDPL--ARRLAARAGAAVVSVD---------------YRLApehpfpaALEDAYAA 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026943992 574 ITAVRKFIEMGFIDEKRIAIWGWSYGGY-VSSLALA---SGTGLFKCGIAVAPVSSWEyyASVYTERFMGL-PTkddnle 648
Cdd:COG0657    71 LRWLRANAAELGIDPDRIAVAGDSAGGHlAAALALRardRGGPRPAAQVLIYPVLDLT--ASPLRADLAGLpPT------ 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026943992 649 hyknstvmaraeyfrnvdyLLIHGTADDNVhfQNSAQIAKALVNAQVDFQAMWYSDQNHGLSGLS----TNHLYTHMTHF 724
Cdd:COG0657   143 -------------------LIVTGEADPLV--DESEALAAALRAAGVPVELHVYPGGGHGFGLLAglpeARAALAEIAAF 201


                  ....*.
gi 1026943992 725 LKQCFS 730
Cdd:COG0657   202 LRRALA 207
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 41-197 6.33e-05

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 43.89  E-value: 6.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026943992  41 LHQSADNNIVLYNIETGQSYTILSNRTMKSVNAsnygLSPDRQFVYLESDYSKLWRYsytatyYIYDLSNGEFVRGNELP 120
Cdd:COG0823     5 LSRDGNSDIYVVDLDGGEPRRLTNSPGIDTSPA----WSPDGRRIAFTSDRGGGPQI------YVVDADGGEPRRLTFGG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026943992 121 RPIQYLCWSPVGSKLAYVYQNN----IYLKQRPGDPPFQITFNGREnkifngipdwvyeeemlPTkyalwWSPNGKFLAY 196
Cdd:COG0823    75 GYNASPSWSPDGKRLAFVSRSDgrfdIYVLDLDGGAPRRLTDGPGS-----------------PS-----WSPDGRRIVF 132


                  .
gi 1026943992 197 A 197
Cdd:COG0823   133 S 133
YpfH COG0400
Predicted esterase [General function prediction only];
559-710 9.17e-05

Predicted esterase [General function prediction only];


Pssm-ID: 440169 [Multi-domain]  Cd Length: 200  Bit Score: 44.13  E-value: 9.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026943992 559 YAVYRKLGVYEVEDQITAVRKFIEmgFIDE---------KRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPvssweyy 629
Cdd:COG0400    52 FDLSFLEGREDEEGLAAAAEALAA--FIDElearygidpERIVLAGFSQGAAMALSLALRRPELLAGVVALSG------- 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026943992 630 asvyterfmGLPTKDDnlehyknstVMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYsDQNHGL 709
Cdd:COG0400   123 ---------YLPGEEA---------LPAPEAALAGTPVFLAHGTQDPVIPVERAREAAEALEAAGADVTYREY-PGGHEI 183


                  .
gi 1026943992 710 S 710
Cdd:COG0400   184 S 184
Peptidase_S15 pfam02129
X-Pro dipeptidyl-peptidase (S15 family);
502-629 1.64e-04

X-Pro dipeptidyl-peptidase (S15 family);


Pssm-ID: 396621 [Multi-domain]  Cd Length: 264  Bit Score: 43.87  E-value: 1.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026943992 502 DRSKKYPLL--IQVYGGPCSQSVRSVFAVNWISYLASkeGMVIALVDGRGTAFQGdkllyavyrklGVYEVE--DQITAV 577
Cdd:pfam02129  14 KTGGPVPALltRSPYGARRDGASDLALAHPEWEFAAR--GYAVVYQDVRGTGGSE-----------GVFTVGgpQEAADG 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1026943992 578 RKFIEmgFIDEK-----RIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYY 629
Cdd:pfam02129  81 KDVID--WLAGQpwcngKVGMTGISYLGTTQLAAAATGPPGLKAIAPESGISDLYDY 135
Fes COG2382
Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];
497-698 7.06e-04

Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];


Pssm-ID: 441948 [Multi-domain]  Cd Length: 314  Bit Score: 42.53  E-value: 7.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026943992 497 LPPQFD-RSKKYPLLIQVYGGPCSQS--VRSVFAVNWI-SYLASKEG--MVIALVDGRGTAFQGdkllyAVYRKLGVYE- 569
Cdd:COG2382   101 LPPGYDnPGKKYPVLYLLDGGGGDEQdwFDQGRLPTILdNLIAAGKIppMIVVMPDGGDGGDRG-----TEGPGNDAFEr 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026943992 570 --VEDQITAVRKfiEMGFIDE-KRIAIWGWSYGGYVSSLALASGTGLFKcgiAVAPVSSweyyasvyterfmGLPTKDDN 646
Cdd:COG2382   176 flAEELIPFVEK--NYRVSADpEHRAIAGLSMGGLAALYAALRHPDLFG---YVGSFSG-------------SFWWPPGD 237

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1026943992 647 LEHYKNSTVMARAEYFRNVDYLLIHGTADDNVhfQNSAQIAKALVNAQVDFQ 698
Cdd:COG2382   238 ADRGGWAELLAAGAPKKPLRFYLDVGTEDDLL--EANRALAAALKAKGYDVE 287
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 568-695 2.69e-03

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 39.98  E-value: 2.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1026943992 568 YEVEDQITAVRKFIEmgFIDEKRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVssWEYYASVYTERFMGLPTKDDNL 647
Cdd:COG0596    70 YTLDDLADDLAALLD--ALGLERVVLVGHSMGGMVALELAARHPERVAGLVLVDEV--LAALAEPLRRPGLAPEALAALL 145

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1026943992 648 EHYKNSTVMARAEYFRnVDYLLIHGTADDNVHFQNSAQIAKALVNAQV 695
Cdd:COG0596   146 RALARTDLRERLARIT-VPTLVIWGEKDPIVPPALARRLAELLPNAEL 192
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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