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Conserved domains on  [gi|1023063245|gb|ANB19836|]
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3-isopropylmalate dehydrogenase [Alteromonas stellipolaris]

Protein Classification

3-isopropylmalate dehydrogenase( domain architecture ID 10011514)

3-isopropylmalate dehydrogenase catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate

CATH:  3.40.718.10
EC:  1.1.1.85
Gene Symbol:  leuB
Gene Ontology:  GO:0003862|GO:0046872|GO:0051287
SCOP:  4000791

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 3-361 0e+00

3-isopropylmalate dehydrogenase; Provisional


:

Pssm-ID: 234832  Cd Length: 358  Bit Score: 615.57  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245   3 QFSIAVLAGDGIGPEVMQEANKVLDAVEKKFNVAFNRTAYPVGGYAIDTEGEALPSKTLLGCEQADAILFGSIGGPKWDT 82
Cdd:PRK00772    2 TYKIAVLPGDGIGPEVMAEAVKVLDAVAEKFGFDFEFEEALVGGAAIDAHGVPLPEETLEACRAADAVLLGAVGGPKWDN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245  83 LPLEQRPERAaLLTLRSHFDLFSNLRPARIYPGLEALSPLREDIAKsGVDVLVVRELTSGIYFGQPKGREGEGEEEFAFD 162
Cdd:PRK00772   82 LPPDVRPERG-LLALRKELGLFANLRPAKLYPGLADASPLKPEIVA-GLDILIVRELTGGIYFGEPRGREGLGGEERAFD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 163 TMRYSKREIRRIAVAAFEAAQKRRGKVTSVDKANVLLTSRLWREVTEEVAKDYPDVELDHIYIDNATMQIMKNPAQFDVM 242
Cdd:PRK00772  160 TMVYTREEIERIARVAFELARKRRKKVTSVDKANVLESSRLWREVVTEVAKEYPDVELSHMYVDNAAMQLVRNPKQFDVI 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 243 LCSNLFGDIVSDECAMMTGSMGLLASASMNEDGFGLYEPAGGSAPDIAGLGIANPIAQVLSAAMMLRFSMNLTDAADAIE 322
Cdd:PRK00772  240 VTENLFGDILSDEAAMLTGSLGMLPSASLGESGPGLYEPIHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEEAADAIE 319

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 1023063245 323 KAVIATLEAGVLTGELLPDDKRenaSTTSQVGDEIVKQL 361
Cdd:PRK00772  320 AAVEKVLAQGYRTADIAEGGGK---VSTSEMGDAILAAL 355
 
Name Accession Description Interval E-value
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 3-361 0e+00

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 234832  Cd Length: 358  Bit Score: 615.57  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245   3 QFSIAVLAGDGIGPEVMQEANKVLDAVEKKFNVAFNRTAYPVGGYAIDTEGEALPSKTLLGCEQADAILFGSIGGPKWDT 82
Cdd:PRK00772    2 TYKIAVLPGDGIGPEVMAEAVKVLDAVAEKFGFDFEFEEALVGGAAIDAHGVPLPEETLEACRAADAVLLGAVGGPKWDN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245  83 LPLEQRPERAaLLTLRSHFDLFSNLRPARIYPGLEALSPLREDIAKsGVDVLVVRELTSGIYFGQPKGREGEGEEEFAFD 162
Cdd:PRK00772   82 LPPDVRPERG-LLALRKELGLFANLRPAKLYPGLADASPLKPEIVA-GLDILIVRELTGGIYFGEPRGREGLGGEERAFD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 163 TMRYSKREIRRIAVAAFEAAQKRRGKVTSVDKANVLLTSRLWREVTEEVAKDYPDVELDHIYIDNATMQIMKNPAQFDVM 242
Cdd:PRK00772  160 TMVYTREEIERIARVAFELARKRRKKVTSVDKANVLESSRLWREVVTEVAKEYPDVELSHMYVDNAAMQLVRNPKQFDVI 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 243 LCSNLFGDIVSDECAMMTGSMGLLASASMNEDGFGLYEPAGGSAPDIAGLGIANPIAQVLSAAMMLRFSMNLTDAADAIE 322
Cdd:PRK00772  240 VTENLFGDILSDEAAMLTGSLGMLPSASLGESGPGLYEPIHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEEAADAIE 319

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 1023063245 323 KAVIATLEAGVLTGELLPDDKRenaSTTSQVGDEIVKQL 361
Cdd:PRK00772  320 AAVEKVLAQGYRTADIAEGGGK---VSTSEMGDAILAAL 355
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 6-361 0e+00

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 543.45  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245   6 IAVLAGDGIGPEVMQEANKVLDAVEKKFNVAFNRTAYPVGGYAIDTEGEALPSKTLLGCEQADAILFGSIGGPKWDTlpl 85
Cdd:COG0473     4 IAVLPGDGIGPEVVAAALKVLEAAAERFGLDFEFEEADIGGAAYDKTGTPLPDETLEALRKADAILLGAVGGPKWDD--- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245  86 EQRPERAaLLTLRSHFDLFSNLRPARIYPGLEalSPLREDIAKsGVDVLVVRELTSGIYFGQPKGREGEGEEEFAFDTMR 165
Cdd:COG0473    81 GVRPESG-LLALRKELDLYANLRPAKLYPGLP--SPLKPEIVE-GIDLVIVRENTEGLYFGIGGRIGTGTGEEVAIDTRV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 166 YSKREIRRIAVAAFEAAQKRRGKVTSVDKANVL-LTSRLWREVTEEVAKDYPDVELDHIYIDNATMQIMKNPAQFDVMLC 244
Cdd:COG0473   157 YTRKGIERIARYAFELARKRRKKVTSVDKANVLkLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFDVIVT 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 245 SNLFGDIVSDECAMMTGSMGLLASASMNEDGFGLYEPAGGSAPDIAGLGIANPIAQVLSAAMMLRFSmNLTDAADAIEKA 324
Cdd:COG0473   237 ENLFGDILSDLAAGLTGSLGLAPSANIGDEGKALFEPVHGSAPDIAGKGIANPIATILSAAMMLRHL-GEEEAADAIEAA 315

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 1023063245 325 VIATLEAGVLTGELLPDdkrenaSTTSQVGDEIVKQL 361
Cdd:COG0473   316 VEKVLAEGVRTPDLGGK------AGTSEMGDAIIAAL 346
leuB TIGR00169
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including ...
 6-357 0e+00

3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the dimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates.Among these decarboxylating dehydrogenases of hydroxyacids, overall sequence homology indicates evolutionary history rather than actual substrate or cofactor specifity, which may be toggled experimentally by replacement of just a few amino acids. 3-isopropylmalate dehydrogenase is an NAD-dependent enzyme and should have a sequence resembling HGSAPDI around residue 340. The subtrate binding loop should include a sequence resembling E[KQR]X(0,1)LLXXR around residue 115. Other contacts of importance are known from crystallography but not detailed here.This model will not find all isopropylmalate dehydrogenases; the enzyme from Sulfolobus sp. strain 7 is more similar to mitochondrial NAD-dependent isocitrate dehydrogenases than to other known isopropylmalate dehydrogenases and was omitted to improve the specificity of the model. It scores below the cutoff and below some enzymes known not to be isopropylmalate dehydrogenase. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 272939  Cd Length: 346  Bit Score: 527.74  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245   6 IAVLAGDGIGPEVMQEANKVLDAVEKKFNVAFNRTAYPVGGYAIDTEGEALPSKTLLGCEQADAILFGSIGGPKWDTLPL 85
Cdd:TIGR00169   2 IAVLPGDGIGPEVMAQALKVLKAVAERFGLKFEFEEHLIGGAAIDATGQPLPEETLKGCKEADAVLLGAVGGPKWDNLPR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245  86 EQRPERAaLLTLRSHFDLFSNLRPARIYPGLEALSPLREDIAKsGVDVLVVRELTSGIYFGQPKGREGEGEeefAFDTMR 165
Cdd:TIGR00169  82 DQRPEQG-LLKLRKSLDLFANLRPAKVFPGLEDLSPLKEEIAK-GVDFVVVRELTGGIYFGEPKGREGEGE---AWDTEV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 166 YSKREIRRIAVAAFEAAQKRRGKVTSVDKANVLLTSRLWREVTEEVAKDYPDVELDHIYIDNATMQIMKNPAQFDVMLCS 245
Cdd:TIGR00169 157 YTVPEIERIARVAFEMARKRRKKVTSVDKANVLESSRLWRKTVEEIAKEYPDVELEHQYIDNAAMQLVKSPTQFDVVVTS 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 246 NLFGDIVSDECAMMTGSMGLLASASMNEDGFGLYEPAGGSAPDIAGLGIANPIAQVLSAAMMLRFSMNLTDAADAIEKAV 325
Cdd:TIGR00169 237 NLFGDILSDEASVITGSLGMLPSASLGSDGFGLFEPVHGSAPDIAGKGIANPIAQILSAAMLLRYSFNLEEAADAIEAAV 316

                         330       340       350
                  ....*....|....*....|....*....|..
gi 1023063245 326 IATLEAGVLTGELLPDDKREnaSTTSQVGDEI 357
Cdd:TIGR00169 317 KKVLAEGYRTPDLGSSATTA--VGTAEMGEEL 346
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
6-357 3.72e-168

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 472.93  E-value: 3.72e-168
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245   6 IAVLAGDGIGPEVMQEANKVLDAVEKKFNVAFNRTAYPVGGYAIDTEGEALPSKTLLGCEQADAILFGSIGGPKWDtlPL 85
Cdd:pfam00180   2 IAVLPGDGIGPEVMAAALKVLKAALEKAPLEFEFEERDVGGAAIDETGEPLPDETLEACKKADAVLLGAVGGPKWD--PA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245  86 EQRPERAaLLTLRSHFDLFSNLRPARIYPGLEALSPLREDIAksGVDVLVVRELTSGIYFGQPKGREGEGEEeFAFDTMR 165
Cdd:pfam00180  80 GVRPENG-LLALRKELGLFANLRPAKVFPPLGDASPLKNEVE--GVDIVIVRELTGGIYFGIEKGIKGSGNE-VAVDTKL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 166 YSKREIRRIAVAAFEAAQKR-RGKVTSVDKANVLLTSRLWRE-VTEEVAKDYPDVELDHIYIDNATMQIMKNPAQFDVML 243
Cdd:pfam00180 156 YSRDEIERIARVAFELARKRgRKKVTSVDKANVLKSSDLWRKiVTEVAKAEYPDVELEHQLVDNAAMQLVKNPSQFDVIV 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 244 CSNLFGDIVSDECAMMTGSMGLLASASMNEDGFGLYEPAGGSAPDIAGLGIANPIAQVLSAAMMLRFSMNLTDAADAIEK 323
Cdd:pfam00180 236 TPNLFGDILSDEASMLTGSLGLLPSASLGANGFGIFEPVHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEDAADKIEA 315

                         330       340       350
                  ....*....|....*....|....*....|....
gi 1023063245 324 AVIATLEAGVLTGELLPDDKrenASTTSQVGDEI 357
Cdd:pfam00180 316 AVLKVLESGIRTGDLAGSAT---YVSTSEFGEAV 346
AksF2_Meth NF040626
homoisocitrate dehydrogenase;
4-364 1.16e-82

homoisocitrate dehydrogenase;


Pssm-ID: 468598  Cd Length: 332  Bit Score: 254.66  E-value: 1.16e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245   4 FSIAVLAGDGIGPEVMQEANKVLDAvekkFNVAFNRTAYPVGGYAIDTEGEALPSKTLLGCEQADAILFGSIggpkwDTL 83
Cdd:NF040626    2 YKITVIPGDGIGKEVMEAALYVLDA----LDLNFDFIEAEAGRECFKKNGTTIPEETIKIAKKSDATLFGAV-----TST 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245  84 PleqrPERAALLTLRSHFDLFSNLRPARIYPGLEALSPlrediaksGVDVLVVRELTSGIYfgqpKGREGEGEEEFAFDT 163
Cdd:NF040626   73 P----GQKSPIITLRKELDLYANLRPIKSYEGINCLFK--------DLDFLIVRENTEGLY----SGLEEEYTEEKAIAE 136

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 164 MRYSKREIRRIAVAAFEAAQKR-RGKVTSVDKANVL-LTSRLWREVTEEVAKDYPDVELDHIYIDNATMQIMKNPAQFDV 241
Cdd:NF040626  137 RVITRKASERICKFAFEYAIKLgRKKVTAVHKANVLkKTDGIFKDTFYKVAKDYPQIETEDYYVDATAMYLITKPQDFDV 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 242 MLCSNLFGDIVSDECAMMTGSMGLLASASMNEDGfGLYEPAGGSAPDIAGLGIANPIAQVLSAAMMLRFsMNLTDAADAI 321
Cdd:NF040626  217 IVTTNLFGDILSDEAAGLVGGLGLAPSANIGDKN-GLFEPVHGSAPDIAGKNIANPIAMILSASMMLDY-LGETYEANKL 294

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1023063245 322 EKAVIATLEAG-VLTGELlpddkrENASTTSQVGDEIVKQLMAQ 364
Cdd:NF040626  295 ENALEKVLREGkVVTPDL------GGNAKTMEMANEIKKKIEEL 332
 
Name Accession Description Interval E-value
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 3-361 0e+00

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 234832  Cd Length: 358  Bit Score: 615.57  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245   3 QFSIAVLAGDGIGPEVMQEANKVLDAVEKKFNVAFNRTAYPVGGYAIDTEGEALPSKTLLGCEQADAILFGSIGGPKWDT 82
Cdd:PRK00772    2 TYKIAVLPGDGIGPEVMAEAVKVLDAVAEKFGFDFEFEEALVGGAAIDAHGVPLPEETLEACRAADAVLLGAVGGPKWDN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245  83 LPLEQRPERAaLLTLRSHFDLFSNLRPARIYPGLEALSPLREDIAKsGVDVLVVRELTSGIYFGQPKGREGEGEEEFAFD 162
Cdd:PRK00772   82 LPPDVRPERG-LLALRKELGLFANLRPAKLYPGLADASPLKPEIVA-GLDILIVRELTGGIYFGEPRGREGLGGEERAFD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 163 TMRYSKREIRRIAVAAFEAAQKRRGKVTSVDKANVLLTSRLWREVTEEVAKDYPDVELDHIYIDNATMQIMKNPAQFDVM 242
Cdd:PRK00772  160 TMVYTREEIERIARVAFELARKRRKKVTSVDKANVLESSRLWREVVTEVAKEYPDVELSHMYVDNAAMQLVRNPKQFDVI 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 243 LCSNLFGDIVSDECAMMTGSMGLLASASMNEDGFGLYEPAGGSAPDIAGLGIANPIAQVLSAAMMLRFSMNLTDAADAIE 322
Cdd:PRK00772  240 VTENLFGDILSDEAAMLTGSLGMLPSASLGESGPGLYEPIHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEEAADAIE 319

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 1023063245 323 KAVIATLEAGVLTGELLPDDKRenaSTTSQVGDEIVKQL 361
Cdd:PRK00772  320 AAVEKVLAQGYRTADIAEGGGK---VSTSEMGDAILAAL 355
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 6-361 0e+00

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 543.45  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245   6 IAVLAGDGIGPEVMQEANKVLDAVEKKFNVAFNRTAYPVGGYAIDTEGEALPSKTLLGCEQADAILFGSIGGPKWDTlpl 85
Cdd:COG0473     4 IAVLPGDGIGPEVVAAALKVLEAAAERFGLDFEFEEADIGGAAYDKTGTPLPDETLEALRKADAILLGAVGGPKWDD--- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245  86 EQRPERAaLLTLRSHFDLFSNLRPARIYPGLEalSPLREDIAKsGVDVLVVRELTSGIYFGQPKGREGEGEEEFAFDTMR 165
Cdd:COG0473    81 GVRPESG-LLALRKELDLYANLRPAKLYPGLP--SPLKPEIVE-GIDLVIVRENTEGLYFGIGGRIGTGTGEEVAIDTRV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 166 YSKREIRRIAVAAFEAAQKRRGKVTSVDKANVL-LTSRLWREVTEEVAKDYPDVELDHIYIDNATMQIMKNPAQFDVMLC 244
Cdd:COG0473   157 YTRKGIERIARYAFELARKRRKKVTSVDKANVLkLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFDVIVT 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 245 SNLFGDIVSDECAMMTGSMGLLASASMNEDGFGLYEPAGGSAPDIAGLGIANPIAQVLSAAMMLRFSmNLTDAADAIEKA 324
Cdd:COG0473   237 ENLFGDILSDLAAGLTGSLGLAPSANIGDEGKALFEPVHGSAPDIAGKGIANPIATILSAAMMLRHL-GEEEAADAIEAA 315

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 1023063245 325 VIATLEAGVLTGELLPDdkrenaSTTSQVGDEIVKQL 361
Cdd:COG0473   316 VEKVLAEGVRTPDLGGK------AGTSEMGDAIIAAL 346
leuB TIGR00169
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including ...
 6-357 0e+00

3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the dimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates.Among these decarboxylating dehydrogenases of hydroxyacids, overall sequence homology indicates evolutionary history rather than actual substrate or cofactor specifity, which may be toggled experimentally by replacement of just a few amino acids. 3-isopropylmalate dehydrogenase is an NAD-dependent enzyme and should have a sequence resembling HGSAPDI around residue 340. The subtrate binding loop should include a sequence resembling E[KQR]X(0,1)LLXXR around residue 115. Other contacts of importance are known from crystallography but not detailed here.This model will not find all isopropylmalate dehydrogenases; the enzyme from Sulfolobus sp. strain 7 is more similar to mitochondrial NAD-dependent isocitrate dehydrogenases than to other known isopropylmalate dehydrogenases and was omitted to improve the specificity of the model. It scores below the cutoff and below some enzymes known not to be isopropylmalate dehydrogenase. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 272939  Cd Length: 346  Bit Score: 527.74  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245   6 IAVLAGDGIGPEVMQEANKVLDAVEKKFNVAFNRTAYPVGGYAIDTEGEALPSKTLLGCEQADAILFGSIGGPKWDTLPL 85
Cdd:TIGR00169   2 IAVLPGDGIGPEVMAQALKVLKAVAERFGLKFEFEEHLIGGAAIDATGQPLPEETLKGCKEADAVLLGAVGGPKWDNLPR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245  86 EQRPERAaLLTLRSHFDLFSNLRPARIYPGLEALSPLREDIAKsGVDVLVVRELTSGIYFGQPKGREGEGEeefAFDTMR 165
Cdd:TIGR00169  82 DQRPEQG-LLKLRKSLDLFANLRPAKVFPGLEDLSPLKEEIAK-GVDFVVVRELTGGIYFGEPKGREGEGE---AWDTEV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 166 YSKREIRRIAVAAFEAAQKRRGKVTSVDKANVLLTSRLWREVTEEVAKDYPDVELDHIYIDNATMQIMKNPAQFDVMLCS 245
Cdd:TIGR00169 157 YTVPEIERIARVAFEMARKRRKKVTSVDKANVLESSRLWRKTVEEIAKEYPDVELEHQYIDNAAMQLVKSPTQFDVVVTS 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 246 NLFGDIVSDECAMMTGSMGLLASASMNEDGFGLYEPAGGSAPDIAGLGIANPIAQVLSAAMMLRFSMNLTDAADAIEKAV 325
Cdd:TIGR00169 237 NLFGDILSDEASVITGSLGMLPSASLGSDGFGLFEPVHGSAPDIAGKGIANPIAQILSAAMLLRYSFNLEEAADAIEAAV 316

                         330       340       350
                  ....*....|....*....|....*....|..
gi 1023063245 326 IATLEAGVLTGELLPDDKREnaSTTSQVGDEI 357
Cdd:TIGR00169 317 KKVLAEGYRTPDLGSSATTA--VGTAEMGEEL 346
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
6-357 3.72e-168

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 472.93  E-value: 3.72e-168
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245   6 IAVLAGDGIGPEVMQEANKVLDAVEKKFNVAFNRTAYPVGGYAIDTEGEALPSKTLLGCEQADAILFGSIGGPKWDtlPL 85
Cdd:pfam00180   2 IAVLPGDGIGPEVMAAALKVLKAALEKAPLEFEFEERDVGGAAIDETGEPLPDETLEACKKADAVLLGAVGGPKWD--PA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245  86 EQRPERAaLLTLRSHFDLFSNLRPARIYPGLEALSPLREDIAksGVDVLVVRELTSGIYFGQPKGREGEGEEeFAFDTMR 165
Cdd:pfam00180  80 GVRPENG-LLALRKELGLFANLRPAKVFPPLGDASPLKNEVE--GVDIVIVRELTGGIYFGIEKGIKGSGNE-VAVDTKL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 166 YSKREIRRIAVAAFEAAQKR-RGKVTSVDKANVLLTSRLWRE-VTEEVAKDYPDVELDHIYIDNATMQIMKNPAQFDVML 243
Cdd:pfam00180 156 YSRDEIERIARVAFELARKRgRKKVTSVDKANVLKSSDLWRKiVTEVAKAEYPDVELEHQLVDNAAMQLVKNPSQFDVIV 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 244 CSNLFGDIVSDECAMMTGSMGLLASASMNEDGFGLYEPAGGSAPDIAGLGIANPIAQVLSAAMMLRFSMNLTDAADAIEK 323
Cdd:pfam00180 236 TPNLFGDILSDEASMLTGSLGLLPSASLGANGFGIFEPVHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEDAADKIEA 315

                         330       340       350
                  ....*....|....*....|....*....|....
gi 1023063245 324 AVIATLEAGVLTGELLPDDKrenASTTSQVGDEI 357
Cdd:pfam00180 316 AVLKVLESGIRTGDLAGSAT---YVSTSEFGEAV 346
PLN02329 PLN02329
3-isopropylmalate dehydrogenase
 3-361 1.94e-103

3-isopropylmalate dehydrogenase


Pssm-ID: 215188  Cd Length: 409  Bit Score: 310.85  E-value: 1.94e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245   3 QFSIAVLAGDGIGPEVMQEANKVLDAVEKKFNVAFNRTAYPVGGYAIDTEGEALPSKTLLGCEQADAILFGSIGGPKWDT 82
Cdd:PLN02329   46 RYNIALLPGDGIGPEVISVAKNVLQKAGSLEGLEFDFQEMPVGGAALDLVGVPLPEETFTAAKQSDAILLGAIGGYKWDK 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245  83 LPLEQRPErAALLTLRSHFDLFSNLRPARIYPGLEALSPLREDIAKsGVDVLVVRELTSGIYFGQPKG-REGEGEEEFAF 161
Cdd:PLN02329  126 NEKHLRPE-MALFYLRRDLKVFANLRPATVLPQLVDASTLKKEVAE-GVDMMIVRELTGGIYFGEPRGiTINENGEEVGV 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 162 DTMRYSKREIRRIAVAAFEAAQKRRGKVTSVDKANVLLTSRLWREVTEEVAKDYPDVELDHIYIDNATMQIMKNPAQFDV 241
Cdd:PLN02329  204 STEIYAAHEIDRIARVAFETARKRRGKLCSVDKANVLDASILWRKRVTALASEYPDVELSHMYVDNAAMQLIRDPKQFDT 283

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 242 MLCSNLFGDIVSDECAMMTGSMGLLASASMNEDGFGLYEPAGGSAPDIAGLGIANPIAQVLSAAMMLRFSMNLTDAADAI 321
Cdd:PLN02329  284 IVTNNIFGDILSDEASMITGSIGMLPSASLGESGPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYGLGEEKAAKRI 363

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 1023063245 322 EKAVIATLEAGVLTGELL-PDDKRENAsttSQVGDEIVKQL 361
Cdd:PLN02329  364 EDAVVDALNKGFRTGDIYsPGNKLVGC---KEMGEEVLKSV 401
PRK03437 PRK03437
3-isopropylmalate dehydrogenase; Provisional
 2-361 2.90e-92

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 179579  Cd Length: 344  Bit Score: 279.89  E-value: 2.90e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245   2 SQFSIAVLAGDGIGPEVMQEANKVLDAVEKKfNVAFNRTAYPVGGYAIDTEGEALPSKTLLGCEQADAILFGSIGGPKWD 81
Cdd:PRK03437    3 KTMKLAVIPGDGIGPEVVAEALKVLDAVAAG-GPGVETTEYDLGARRYLRTGETLPDSVLAELRQHDAILLGAIGDPSVP 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245  82 TLPLEqrpeRAALLTLRSHFDLFSNLRPARIYPGLEalSPLR--EDIaksgvDVLVVRELTSGIYFGQPKGREGEGEEEF 159
Cdd:PRK03437   82 SGVLE----RGLLLKLRFALDHYVNLRPSKLYPGVT--SPLAgpGDI-----DFVVVREGTEGPYTGNGGALRVGTPHEV 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 160 AFDTMRYSKREIRRIAVAAFEAAQKR-RGKVTSVDKANVLLTS-RLWREVTEEVAKDYPDVELDHIYIDNATMQIMKNPA 237
Cdd:PRK03437  151 ATEVSVNTAFGVERVVRDAFERAQKRpRKHLTLVHKTNVLTFAgDLWQRTVDEVAAEYPDVTVDYQHVDAATIFMVTDPS 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 238 QFDVMLCSNLFGDIVSDECAMMTGSMGLLASASMNEDGFG--LYEPAGGSAPDIAGLGIANPIAQVLSAAMMLRFsMNLT 315
Cdd:PRK03437  231 RFDVIVTDNLFGDIITDLAAAVTGGIGLAASGNINPTGTNpsMFEPVHGSAPDIAGQGIADPTAAILSVALLLDH-LGEE 309

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 1023063245 316 DAADAIEKAVIATLEAgvltgellpDDKRenASTTSQVGDEIVKQL 361
Cdd:PRK03437  310 DAAARIEAAVEADLAE---------RGKM--GRSTAEVGDRIAARL 344
LEU3_arch TIGR02088
isopropylmalate/isohomocitrate dehydrogenases; This model represents a group of archaeal ...
 6-357 2.75e-84

isopropylmalate/isohomocitrate dehydrogenases; This model represents a group of archaeal decarboxylating dehydrogenases which include the leucine biosynthesis enzyme 3-isopropylmalate dehydrogenase (LeuB, LEU3) and the methanogenic cofactor CoB biosynthesis enzyme isohomocitrate dehydrogenase (AksF). Both of these have been characterized in Methanococcus janaschii. Non-methanogenic archaea have only one hit to this model and presumably this is LeuB, although phylogenetic trees cannot establish which gene is which in the methanogens. The AksF gene is capable of acting on isohomocitrate, iso(homo)2-citrate and iso(homo)3-citrate in the successive elongation cycles of coenzyme B (7-mercaptoheptanoyl-threonine phosphate). This family is closely related to both the LeuB genes found in TIGR00169 and the mitochondrial eukaryotic isocitrate dehydratases found in TIGR00175. All of these are included within the broader subfamily model, pfam00180.


Pssm-ID: 273962  Cd Length: 322  Bit Score: 258.54  E-value: 2.75e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245   6 IAVLAGDGIGPEVMQEANKVLDavekKFNVAFNRTAYPVGGYAIDTEGEALPSKTLLGCEQADAILFGSIGGPKwdtlpl 85
Cdd:TIGR02088   1 VAVIPGDGIGPEVIEAAIRILN----KLGLEIEFIEFEAGDEALKKYGSALPEDTLEEIRKADAILFGAVTTPA------ 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245  86 eQRPERAALLTLRSHFDLFSNLRPARIYPGLEALSPLrediaksGVDVLVVRELTSGIYFGqpkgregegeEEFAFDTMR 165
Cdd:TIGR02088  71 -NPGYKSVIVTLRKELDLYANVRPAKSLPGIPDLYPN-------GKDIVIVRENTEGLYAG----------FEFGFSDRA 132

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 166 YSKREI-----RRIAVAAFEAAQKRRGKVTSVDKANVL-LTSRLWREVTEEVAKDYpDVELDHIYIDNATMQIMKNPAQF 239
Cdd:TIGR02088 133 IAIRVItregsERIARFAFNLAKERNRKVTCVHKANVLkGTDGLFREVCREIAKRY-GVEYRDMYVDSAAMNLVKDPWRF 211

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 240 DVMLCSNLFGDIVSDECAMMTGSMGLLASASMNEDgFGLYEPAGGSAPDIAGLGIANPIAQVLSAAMMLRFsMNLTDAAD 319
Cdd:TIGR02088 212 DVIVTTNMFGDILSDLASALAGSLGLAPSANIGDR-KALFEPVHGSAPDIAGKGIANPTAAILSVAMMLDY-LGELEKGK 289

                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 1023063245 320 AIEKAVIATLEAGVLTGELLPDdkrenaSTTSQVGDEI 357
Cdd:TIGR02088 290 LVWEAVEYYIIEGKKTPDLGGT------AKTKEVGDEI 321
AksF2_Meth NF040626
homoisocitrate dehydrogenase;
4-364 1.16e-82

homoisocitrate dehydrogenase;


Pssm-ID: 468598  Cd Length: 332  Bit Score: 254.66  E-value: 1.16e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245   4 FSIAVLAGDGIGPEVMQEANKVLDAvekkFNVAFNRTAYPVGGYAIDTEGEALPSKTLLGCEQADAILFGSIggpkwDTL 83
Cdd:NF040626    2 YKITVIPGDGIGKEVMEAALYVLDA----LDLNFDFIEAEAGRECFKKNGTTIPEETIKIAKKSDATLFGAV-----TST 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245  84 PleqrPERAALLTLRSHFDLFSNLRPARIYPGLEALSPlrediaksGVDVLVVRELTSGIYfgqpKGREGEGEEEFAFDT 163
Cdd:NF040626   73 P----GQKSPIITLRKELDLYANLRPIKSYEGINCLFK--------DLDFLIVRENTEGLY----SGLEEEYTEEKAIAE 136

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 164 MRYSKREIRRIAVAAFEAAQKR-RGKVTSVDKANVL-LTSRLWREVTEEVAKDYPDVELDHIYIDNATMQIMKNPAQFDV 241
Cdd:NF040626  137 RVITRKASERICKFAFEYAIKLgRKKVTAVHKANVLkKTDGIFKDTFYKVAKDYPQIETEDYYVDATAMYLITKPQDFDV 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 242 MLCSNLFGDIVSDECAMMTGSMGLLASASMNEDGfGLYEPAGGSAPDIAGLGIANPIAQVLSAAMMLRFsMNLTDAADAI 321
Cdd:NF040626  217 IVTTNLFGDILSDEAAGLVGGLGLAPSANIGDKN-GLFEPVHGSAPDIAGKNIANPIAMILSASMMLDY-LGETYEANKL 294

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1023063245 322 EKAVIATLEAG-VLTGELlpddkrENASTTSQVGDEIVKQLMAQ 364
Cdd:NF040626  295 ENALEKVLREGkVVTPDL------GGNAKTMEMANEIKKKIEEL 332
TTC TIGR02089
tartrate dehydrogenase; Tartrate dehydrogenase catalyzes the oxidation of both meso- and (+) ...
 1-361 2.81e-80

tartrate dehydrogenase; Tartrate dehydrogenase catalyzes the oxidation of both meso- and (+)-tartrate as well as a D-malate. These enzymes are closely related to the 3-isopropylmalate and isohomocitrate dehydrogenases found in TIGR00169 and TIGR02088, respectively. [Energy metabolism, Other]


Pssm-ID: 273963  Cd Length: 352  Bit Score: 249.37  E-value: 2.81e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245   1 MSQFSIAVLAGDGIGPEVMQEANKVLDAVEKKF-NVAFNRTAYPVGGYAIDTEGEALPSKTLLGCEQADAILFGSIGGPK 79
Cdd:TIGR02089   1 MKQYRIAAIPGDGIGKEVVAAALQVLEAAAKRHgGFSLHFTEFPWSCDYYKEHGKMMPEDGLEKLKKFDAIFLGAVGWPA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245  80 W--DTLPLeqrpeRAALLTLRSHFDLFSNLRPARIYPGLEalSPLREDIAKSgVDVLVVRELTSGIYFGQpKGRE-GEGE 156
Cdd:TIGR02089  81 LvpDHISL-----WGLLLKIRREFDQYANVRPAKLLPGVT--SPLRNCGPGD-FDFVVVRENSEGEYSGV-GGRIhRGTD 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 157 EEFAFDTMRYSKREIRRIAVAAFEAAQKRRGKVTSVDKANVLLTSR-LWREVTEEVAKDYPDVELDHIYIDNATMQIMKN 235
Cdd:TIGR02089 152 EEVATQNAIFTRKGVERIMRFAFELAQKRRKHLTSATKSNGIRHSMpFWDEVFAEVAAEYPDVEWDSYHIDALAARFVLK 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 236 PAQFDVMLCSNLFGDIVSDECAMMTGSMGLLASASMNEDGF--GLYEPAGGSAPDIAGLGIANPIAQVLSAAMMLRfSMN 313
Cdd:TIGR02089 232 PETFDVIVASNLFGDILSDLGAALMGSLGVAPSANINPEGKfpSMFEPVHGSAPDIAGKGIANPIGAIWTAAMMLE-HLG 310

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 1023063245 314 LTDAADAIEKAVIATLEAGVLTGELlpddkrENASTTSQVGDEIVKQL 361
Cdd:TIGR02089 311 EKEAGAKIMDAIERVTAAGILTPDV------GGKATTSEVTEAVCNAL 352
PRK14025 PRK14025
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional
 6-361 4.66e-80

multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional


Pssm-ID: 184462  Cd Length: 330  Bit Score: 248.12  E-value: 4.66e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245   6 IAVLAGDGIGPEVMQEANKVLDAVEkkfnVAFNRTAYPVGGYAIDTEGEALPSKTLLGCEQADAILFGSIGgpkwdtlpl 85
Cdd:PRK14025    4 ICVIEGDGIGKEVVPAALHVLEATG----LPFEFVYAEAGDEVFEKTGKALPEETIEAAKEADAVLFGAAG--------- 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245  86 eqrpERAA--LLTLRSHFDLFSNLRPARIYPGLEALSPlrediaksGVDVLVVRELTSGIYfgqpKGREGEGEEEFAFDT 163
Cdd:PRK14025   71 ----ETAAdvIVKLRRILDTYANVRPVKSYKGVKCLYP--------DIDYVIVRENTEGLY----KGIEAEIADGVTVAT 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 164 MRYSKREIRRIAVAAFEAAQKR-----RGKVTSVDKANVL-LTSRLWREVTEEVAKDYPDVELDHIYIDNATMQIMKNPA 237
Cdd:PRK14025  135 RVITRKASERIFRFAFEMAKRRkkmgkEGKVTCAHKANVLkKTDGLFKKTFYEVAKEYPDIKAEDYYVDAMNMYIITRPQ 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 238 QFDVMLCSNLFGDIVSDECAMMTGSMGLLASASMNEDgFGLYEPAGGSAPDIAGLGIANPIAQVLSAAMMLRFsMNLTDA 317
Cdd:PRK14025  215 TFDVVVTSNLFGDILSDGAAGLVGGLGLAPSANIGDK-YGLFEPVHGSAPDIAGKGIANPTATILTAVLMLRH-LGENEE 292

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1023063245 318 ADAIEKAVIATLEAGVLTGELlpddkrENASTTSQVGDEIVKQL 361
Cdd:PRK14025  293 ADKVEKALEEVLALGLTTPDL------GGNLSTMEMAEEVAKRV 330
PRK08194 PRK08194
tartrate dehydrogenase; Provisional
 1-361 2.50e-75

tartrate dehydrogenase; Provisional


Pssm-ID: 181281  Cd Length: 352  Bit Score: 236.54  E-value: 2.50e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245   1 MSQFSIAVLAGDGIGPEVMQEANKVLDAV-EKKFNVAFNRTAYPVGGYAIDTEGEALPSKTLLGCEQADAILFGSIGGPK 79
Cdd:PRK08194    1 MKQFKIAVIPGDGVGKEVVPAAVRVLKAVaEVHGGLKFEFTEFPWSCEYYLEHGEMMPEDGLEQLKQFDAIFLGAVGNPK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245  80 W--DTLPLeqrpeRAALLTLRSHFDLFSNLRPARIYPGLEalSPLREdiaKSGVDVLVVRELTSGIYfGQPKGREGEGEE 157
Cdd:PRK08194   81 LvpDHISL-----WGLLIKIRREFEQVINIRPAKQLRGIK--SPLAN---PKDFDLLVVRENSEGEY-SEVGGRIHRGED 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 158 EFAFDTMRYSKREIRRIAVAAFEAAQKRRGKVTSVDKAN-VLLTSRLWREVTEEVAKDYPDVELDHIYIDNATMQIMKNP 236
Cdd:PRK08194  150 EIAIQNAVFTRKGTERAMRYAFELAAKRRKHVTSATKSNgIVHSMPFWDEVFQEVGKDYPEIETDSQHIDALAAFFVTRP 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 237 AQFDVMLCSNLFGDIVSDECAMMTGSMGLLASASMNEDGF--GLYEPAGGSAPDIAGLGIANPIAQVLSAAMMLRfSMNL 314
Cdd:PRK08194  230 EEFDVIVASNLFGDILTDIGAAIMGSIGIAPAANINVNGKypSMFEPVHGSAPDIAGKGIANPIGQIWTAKLMLD-HFGE 308

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 1023063245 315 TDAADAIEKAVIATLEAGVLTGELlpddkrENASTTSQVGDEIVKQL 361
Cdd:PRK08194  309 EELGSHLLDVIEDVTEDGIKTPDI------GGRATTDEVTDEIISRL 349
PRK08997 PRK08997
isocitrate dehydrogenase; Provisional
 1-338 3.43e-71

isocitrate dehydrogenase; Provisional


Pssm-ID: 181606  Cd Length: 334  Bit Score: 225.37  E-value: 3.43e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245   1 MSQfSIAVLAGDGIGPEVMQEANKVLDAVEKKFNVAFnrtaYPVGGYAIDTEGEALPSKTLLGCEQADAILFGSIGGPKW 80
Cdd:PRK08997    1 MKQ-TITVIPGDGIGPSIIDATLKILDKLGCDFEYEF----ADAGLTALEKHGELLPQRTLDLIEKNKIALKGPLTTPVG 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245  81 DTLPleqrperAALLTLRSHFDLFSNLRPARIYPGLEAlsplREDiaksGVDVLVVRELTSGIYFGQpkGREGEGEEEFA 160
Cdd:PRK08997   76 EGFT-------SINVTLRKKFDLYANVRPVLSFPGTKA----RYD----NIDIITVRENTEGMYSGE--GQTVSEDGETA 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 161 FDTMRYSKREIRRIAVAAFEAAQKR-RGKVTSVDKANVL-LTSRLWREVTEEVAKDYPDVELDHIYIDNATMQIMKNPAQ 238
Cdd:PRK08997  139 EATSIITRKGAERIVRFAYELARKEgRKKVTAVHKANIMkSTSGLFLKVAREVALRYPDIEFEEMIVDATCMQLVMNPEQ 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 239 FDVMLCSNLFGDIVSDECAMMTGSMGLLASASMNEDGfGLYEPAGGSAPDIAGLGIANPIAQVLSAAMMLRFsMNLTDAA 318
Cdd:PRK08997  219 FDVIVTTNLFGDILSDLCAGLVGGLGMAPGANIGRDA-AIFEAVHGSAPDIAGKNLANPTSVILAAIQMLEY-LGMPDKA 296

                         330       340
                  ....*....|....*....|.
gi 1023063245 319 DAIEKAVIATLEAG-VLTGEL 338
Cdd:PRK08997  297 ERIRKAIVAVIEAGdRTTRDL 317
mito_nad_idh TIGR00175
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent ...
 4-361 4.66e-61

isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. Mitochondrial NAD-dependent isocitrate dehydrogenases (IDH) resemble prokaryotic NADP-dependent IDH and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent IDH. The mitochondrial NAD-dependent isocitrate dehydrogenase is believed to be an alpha(2)-beta-gamma heterotetramer. All subunits are homologous and found by this model. The NADP-dependent IDH of Thermus aquaticus thermophilus strain HB8 resembles these NAD-dependent IDH, except for the residues involved in cofactor specificity, much more closely than it resembles other prokaryotic NADP-dependent IDH, including that of Thermus aquaticus strain YT1. [Energy metabolism, TCA cycle]


Pssm-ID: 272942  Cd Length: 333  Bit Score: 199.14  E-value: 4.66e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245   4 FSIAVLAGDGIGPEVMqeankvlDAVEKKFNVAfnrtAYPVGGYAIDTEGEAlPSKTLLGCEQADAILFGSIG--GPkWD 81
Cdd:TIGR00175   4 YTVTLIPGDGIGPEIS-------GSVKKIFRAA----NVPIEFEEIDVSPQT-DGKTEIPDEAVESIKRNKVAlkGP-LE 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245  82 TlPLEQRPERAALLTLRSHFDLFSNLRPARIYPGLealsPLREDiaksGVDVLVVRELTSGIYFGqpkgrEGEGEEEFAF 161
Cdd:TIGR00175  71 T-PIGKGGHRSLNVALRKELDLYANVVHCKSLPGF----KTRHE----DVDIVIIRENTEGEYSG-----LEHESVPGVV 136

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 162 DTMRYSKRE-IRRIAVAAFEAAQKR-RGKVTSVDKANVL-LTSRLWREVTEEVAKDYPDVELDHIYIDNATMQIMKNPAQ 238
Cdd:TIGR00175 137 ESLKVITRDkSERIARYAFEYARKNgRKKVTAVHKANIMkLADGLFLNVCREVAKEYPDITFESMIVDNTCMQLVSRPSQ 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 239 FDVMLCSNLFGDIVSDECAMMTGSMGLLASASMNEDGFGLYEPAGGSAPDIAGLGIANPIAQVLSAAMMLRfSMNLTDAA 318
Cdd:TIGR00175 217 FDVMVMPNLYGNILSNLGAGLVGGPGLVPGANIGRDYAVFEPGVRHTGPDIAGQNIANPTALILSSVMMLN-HLGLKEHA 295

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1023063245 319 DAIEKAVIATLEAG-VLTGELlpddkrENASTTSQVGDEIVKQL 361
Cdd:TIGR00175 296 DRIQKAVLSTIAEGkNRTKDL------GGTATTSDFTEAVIKRL 333
PRK09222 PRK09222
NADP-dependent isocitrate dehydrogenase;
6-350 2.64e-54

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 236416 [Multi-domain]  Cd Length: 482  Bit Score: 185.48  E-value: 2.64e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245   6 IAVLAGDGIGPEVMQEANKVLDAVEKKFnvafnrtaypvggyAIDT-E-GEALPSKtllgceqadAILFGsIGGPKWDTL 83
Cdd:PRK09222    7 ITVAYGDGIGPEIMEAVLKILEAAGAPL--------------EIETiEiGEKVYKK---------GWTSG-ISPSAWESI 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245  84 ---------PLEQrP----ERAALLTLRSHFDLFSNLRPARIY-PGLEALSPlrediaksGVDVLVVRE----LTSGIYF 145
Cdd:PRK09222   63 rrtkvllkaPITT-PqgggYKSLNVTLRKTLGLYANVRPCVSYhPFVETKHP--------NLDVVIIREneedLYAGIEH 133

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 146 GQPKgregegeeefafDTMRYSKREIR----RIAVAAFEAAQKR-RGKVTSVDKANVL-LTSRLWREVTEEVAKDYPDVE 219
Cdd:PRK09222  134 RQTP------------DVYQCLKLISRpgseKIIRYAFEYARANgRKKVTCLTKDNIMkLTDGLFHKVFDEIAKEYPDIE 201

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 220 LDHIYIDNATMQIMKNPAQFDVMLCSNLFGDIVSDECAMMTGSMGLLASASMNEDGfGLYEPAGGSAPDIAGLGIANPIA 299
Cdd:PRK09222  202 AEHYIVDIGAARLATNPENFDVIVTPNLYGDILSDIAAEISGSVGLAGSANIGEEY-AMFEAVHGSAPDIAGKNIANPSG 280

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1023063245 300 QVLSAAMMLRFsMNLTDAADAIEKAVIATLEAGVLTGELLPDDK-RENASTT 350
Cdd:PRK09222  281 LLNAAVMMLVH-IGQFDIAELIENAWLKTLEDGIHTADIYNEGVsKKKVGTK 331
PLN00118 PLN00118
isocitrate dehydrogenase (NAD+)
 11-338 1.20e-50

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215062  Cd Length: 372  Bit Score: 173.14  E-value: 1.20e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245  11 GDGIGPEVMQEANKVLDAVEkkfnVAFNRTAYPVGGyAIDTEgealpSKTLLGCEQADAILFGSIG--GPKwdTLPLeQR 88
Cdd:PLN00118   49 GDGIGPEIAESVKQVFTAAG----VPIEWEEHYVGT-TVDPR-----TGSFLTWESLESVRRNKVGlkGPM--ATPI-GK 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245  89 PERAALLTLRSHFDLFSNLRPARIYPGLEAlsplREDiaksGVDVLVVRELTSGIYFGQPKGREGEGEEEFAFDTMRYSK 168
Cdd:PLN00118  116 GHRSLNLTLRKELGLYANVRPCYSLPGYKT----RYD----DVDLVTIRENTEGEYSGLEHQVVRGVVESLKIITRQASL 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 169 ReirrIAVAAFEAAQKR-RGKVTSVDKANVLL-TSRLWREVTEEVAKDYPDVELDHIYIDNATMQIMKNPAQFDVMLCSN 246
Cdd:PLN00118  188 R----VAEYAFHYAKTHgRKRVSAIHKANIMKkTDGLFLKCCREVAEKYPEIVYEEVIIDNCCMMLVKNPALFDVLVMPN 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 247 LFGDIVSDECAMMTGSMGLLASASMNEDGFGLYEPAGGSAPDIAGLGIANPIAQVLSAAMMLRfSMNLTDAADAIEKAVI 326
Cdd:PLN00118  264 LYGDIISDLCAGLIGGLGLTPSCNIGENGLALAEAVHGSAPDIAGKNLANPTALLLSAVMMLR-HLKLNEQAEQIHNAIL 342

                         330
                  ....*....|...
gi 1023063245 327 ATLEAG-VLTGEL 338
Cdd:PLN00118  343 NTIAEGkYRTADL 355
Icd COG0538
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ...
 11-361 3.89e-50

Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440304  Cd Length: 409  Bit Score: 172.99  E-value: 3.89e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245  11 GDGIGPEVMQEANKVLD-AVEKkfnvAFNRT------AYPVGGYAIDTEGEALPSKTllgceqADAIL-FG-SIGGPKwd 81
Cdd:COG0538    26 GDGIGPEITRAIWKVIDaAVEK----AYGGKrdiewkEVDAGEKARDETGDWLPDET------AEAIKeYGvGIKGPL-- 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245  82 TLPLEQ--RPERAallTLRSHFDLFSNLRPARIYPGLEalSPLR--EDiaksgVDVLVVRELTSGIYFG---QPKGREGE 154
Cdd:COG0538    94 TTPVGGgwRSLNV---TIRQILDLYVCRRPVRYFKGVP--SPVKhpEK-----VDIVIFRENTEDIYAGiewKAGSPEAL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 155 GEEEFAFDTMR----------------YSKREIRRIAVAAFE-AAQKRRGKVTSVDKANVL------------------- 198
Cdd:COG0538   164 KLIFFLEDEMGvtvirfpedsgigikpVSDEGTERLVRAAIQyALDNKRKSVTLVHKGNIMkftegafkdwgyevaeeef 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 199 ----LTSRLWREVTEEVAKDypDVELDHIYIDNATMQIMKNPAQFDVMLCSNLFGDIVSDECAMMTGSMGLLASASMNED 274
Cdd:COG0538   244 gdkfITEGPWEKYKGPKPAG--KIVYKDRIADDMLQQILLRPGEYDVIATKNLNGDYISDALAAQVGGLGIAPGANIGDD 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 275 GFGLYEPAGGSAPDIAGLGIANPIAQVLSAAMMLRFsMNLTDAADAIEKAVIATLEAGVLTGEL--LPDDKRENasTTSQ 352
Cdd:COG0538   322 GGAEFEATHGTAPKYAGKDSTNPGSLILSGTMMLRH-RGWLEAADLIEKAVEKTIESGKVTYDLarLMEGATEL--STSE 398


                  ....*....
gi 1023063245 353 VGDEIVKQL 361
Cdd:COG0538   399 FGDAIIENL 407
PRK06451 PRK06451
NADP-dependent isocitrate dehydrogenase;
6-338 4.94e-34

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 235803  Cd Length: 412  Bit Score: 129.95  E-value: 4.94e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245   6 IAVLAGDGIGPEVMQEANKVLD-AVEKKFNVAFNRTAYPV--GGYAIDTEGEALPSKTLLGCEQADAILFGSIGGP---K 79
Cdd:PRK06451   26 ILYVEGDGIGPEITHAAMKVINkAVEKAYGSDREIKWVEVlaGDKAEKLTGNRFPKESEELIEKYRVLLKGPLETPigkG 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245  80 WdtlpleqrpeRAALLTLRSHFDLFSNLRPARIYPGLEalSPLREdiaKSGVDVLVVRELTSGIYFG--------QPKGR 151
Cdd:PRK06451  106 W----------KSINVAIRLMLDLYANIRPVKYIPGIE--SPLKN---PEKIDLIIFRENTDDLYRGieypydseEAKKI 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 152 EGEGEEEFAFDT-----------MRYSKREIRRIAVAAfeAAQKRRGKVTSVDKANVL-LTSRLWRE------------- 206
Cdd:PRK06451  171 RDFLRKELGVEVeddtgigikliSKFKTQRIARMAIKY--AIDHKRKKVTIMHKGNVMkYTEGAFREwayevalkefrdy 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 207 -VTE-EVAKDYPDVE------LDHIYIDNATMQIMKNPAQFDVMLCSNLFGDIVSDECAMMTGSMGLLASASMNEDGfGL 278
Cdd:PRK06451  249 vVTEeEVTKNYNGVPpsgkviINDRIADNMFQQIIIRPDEYDIILAPNVNGDYISDAAGALVGNIGMLGGANIGDTG-GM 327

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 279 YEPAGGSAPDIAGLGIANPIAQVLSAAMMLRFsMNLTDAADAIEKAVIATLEAGVLTGEL 338
Cdd:PRK06451  328 FEAIHGTAPKYAGKNVANPTGIIKGGELMLRF-MGWDKAADLIDKAIMESIKQKKVTQDL 386
PLN00123 PLN00123
isocitrate dehydrogenase (NAD+)
 6-361 1.26e-33

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215065  Cd Length: 360  Bit Score: 127.67  E-value: 1.26e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245   6 IAVLAGDGIGPEVMQEANKVLDAVEKKfnVAFNRtaypvggYAIDTEGEALPSKTLLGCEQADAILFGSIGGP-KWDTLP 84
Cdd:PLN00123   33 VTLIPGDGIGPLVTGAVEQVMEAMHAP--VYFER-------YEVHGDMKKVPEEVLESIRRNKVCLKGGLATPvGGGVSS 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245  85 LEqrperaalLTLRSHFDLFSNLRPARIYPGLealsPLREDiaksGVDVLVVRELTSGIYFGQPKGREGEGEEEFAFDTM 164
Cdd:PLN00123  104 LN--------VQLRKELDLFASLVNCFNLPGL----PTRHE----NVDIVVIRENTEGEYSGLEHEVVPGVVESLKVITK 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 165 RYSKreirRIAVAAFEAAQ-KRRGKVTSVDKANVL-LTSRLWREVTEEVAKDYPDVELDHIYIDNATMQIMKNPAQFDVM 242
Cdd:PLN00123  168 FCSE----RIAKYAFEYAYlNNRKKVTAVHKANIMkLADGLFLESCREVAKKYPGIKYNEIIVDNCCMQLVSKPEQFDVM 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 243 LCSNLFGDIVSDECAMMTGSMGLLASASMNeDGFGLYEpAGGSA-----PDIAGLGIANPIAQVLSAAMMLRfSMNLTDA 317
Cdd:PLN00123  244 VTPNLYGNLVANTAAGIAGGTGVMPGGNVG-ADHAVFE-QGASAgnvgnEKLVEQKKANPVALLLSSAMMLR-HLQFPSF 320

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 1023063245 318 ADAIEKAVIATLEAG-VLTGELlpddkrENASTTSQVGDEIVKQL 361
Cdd:PLN00123  321 ADRLETAVKRVIAEGkYRTKDL------GGSSTTQEVVDAVIANL 359
PRK07006 PRK07006
isocitrate dehydrogenase; Reviewed
 6-361 2.57e-29

isocitrate dehydrogenase; Reviewed


Pssm-ID: 180792  Cd Length: 409  Bit Score: 116.70  E-value: 2.57e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245   6 IAVLAGDGIGPEVMQEANKVLDA-VEKKFN---------VAFNRTAYPVGGyaidtEGEALPSKTLlgceqaDAI--LFG 73
Cdd:PRK07006   22 IPFIEGDGIGPDITPAMLKVVDAaVEKAYKgerkiswmeIYAGEKATKVYG-----EDVWLPEETL------DLIreYRV 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245  74 SIGGPKwdTLPLEQRPeRAALLTLRSHFDLFSNLRPARIYPGLEalSPLREdiaKSGVDVLVVRELTSGIYFG------- 146
Cdd:PRK07006   91 AIKGPL--TTPVGGGI-RSLNVALRQELDLYVCLRPVRYFKGVP--SPVKR---PEDTDMVIFRENSEDIYAGiewkags 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 147 -QPKGREGEGEEEFAFDTMRY-----------SKREIRRIAVAAFE-AAQKRRGKVTSVDKANVL-LTSRLWREVTEEVA 212
Cdd:PRK07006  163 aEAKKVIKFLQEEMGVKKIRFpetsgigikpvSEEGTERLVRAAIEyAIDNDRKSVTLVHKGNIMkFTEGAFKDWGYQLA 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 213 -KDYPDVELD---HIYIDNAT----------------MQIMKNPAQFDVMLCSNLFGDIVSDECAMMTGSMGLLASASMN 272
Cdd:PRK07006  243 eEEFGDELIDggpWDKIKNPEtgkeiivkdsiadaflQQILLRPAEYDVIATMNLNGDYISDALAAQVGGIGIAPGANIN 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 273 eDGFGLYEPAGGSAPDIAGLGIANPIAQVLSAAMMLRFsMNLTDAADAIEKAVIATLEAGVLTGEL--LPDDKREnaSTT 350
Cdd:PRK07006  323 -DGHAIFEATHGTAPKYAGLDKVNPGSVILSAEMMLRH-MGWTEAADLIIKSMEKTIASKTVTYDFarLMEGATE--VKC 398

                         410
                  ....*....|.
gi 1023063245 351 SQVGDEIVKQL 361
Cdd:PRK07006  399 SEFGDALIKNM 409
PRK07362 PRK07362
NADP-dependent isocitrate dehydrogenase;
6-338 2.31e-11

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 180944  Cd Length: 474  Bit Score: 64.73  E-value: 2.31e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245   6 IAVLAGDGIGPEVMQEANKVLD-AVEKKFNVAFNRTAYPV--GGYAIDTEG--EALPSKTLLGCEQadailFG-SIGGPK 79
Cdd:PRK07362   31 IPFIRGDGTGVDIWPATQKVLDaAVAKAYGGERKINWFKVyaGDEACDLYGtyQYLPEDTLEAIRE-----YGvAIKGPL 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245  80 wdTLPLEQRPeRAALLTLRSHFDLFSNLRPARIYPGLEalSPLR--EDIaksgvDVLVVRELTSGIYFG------QPKGR 151
Cdd:PRK07362  106 --TTPIGGGI-RSLNVALRQIFDLYSCVRPCRYYAGTP--SPHKnpEKL-----DVIVYRENTEDIYMGieweagDEIGD 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 152 EGEGE--EEFAFDTMRYSKREIR----------------RIAVAAFEAA---QKRRGKVTSVDKANV------------- 197
Cdd:PRK07362  176 KLIKHlnEEVIPASPELGKRQIPlgsgigikpvsktgsqRHIRRAIEHAlrlPGDKRHVTLVHKGNImkytegafrdwgy 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 198 -LLTSRLWRE-VTEEVA------KDYPDVELDhiyiDNATM--------------------------------------- 230
Cdd:PRK07362  256 eLATTEFRDEcVTERESwilsnkEKNPNISIE----DNARMiepgydsltpekkaaicaevkevldsiwsshgngkwkek 331

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 231 -------------QIMKNPAQFDVMLCSNLFGDIVSDECAMMTGSMGLLASASMNeDGFGLYEPAGGSAPDIAGLGIANP 297
Cdd:PRK07362  332 vlvddriadsifqQIQTRPQEYSILATLNLNGDYISDAAAAIVGGLGMAPGANIG-DNAAIFEATHGTAPKHAGLDRINP 410

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 1023063245 298 IAQVLSAAMMLRFsMNLTDAADAIEKAVIATLEAGVLTGEL 338
Cdd:PRK07362  411 GSVILSGVMMLEY-LGWQEAADLITKGLSAAIANKQVTYDL 450
PRK08299 PRK08299
NADP-dependent isocitrate dehydrogenase;
222-363 8.57e-07

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 236226  Cd Length: 402  Bit Score: 50.24  E-value: 8.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 222 HIYIDNATMQIMKNPAQFdVMLCSNLFGDIVSDECAMMTGSMGLLASASMNEDGFGL-YEPAGG---------------S 285
Cdd:PRK08299  246 HRLIDDMVASALKWEGGY-VWACKNYDGDVQSDTVAQGFGSLGLMTSVLMTPDGKTVeAEAAHGtvtrhyrqhqkgeetS 324

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 286 apdiaglgiANPIAQVLSAAMMLRF------SMNLTDAADAIEKAVIATLEAGVLTGELL----PDDKrenASTTSQVGD 355
Cdd:PRK08299  325 ---------TNPIASIFAWTRGLAHrgkldgNPELVKFADTLEKVCIETVESGFMTKDLAllvgPDQK---WLTTEEFLD 392


                  ....*...
gi 1023063245 356 EIVKQLMA 363
Cdd:PRK08299  393 AIDENLEK 400
PTZ00435 PTZ00435
isocitrate dehydrogenase; Provisional
 222-361 4.79e-05

isocitrate dehydrogenase; Provisional


Pssm-ID: 240417  Cd Length: 413  Bit Score: 44.98  E-value: 4.79e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 222 HIYIDNATMQIMKNPAQFdVMLCSNLFGDIVSDECAMMTGSMGLLASASMNEDGFG-LYEPAGG---------------S 285
Cdd:PTZ00435  249 HRLIDDMVAQAIKSEGGF-VWACKNYDGDVQSDIVAQGYGSLGLMTSVLVCPDGKTvEAEAAHGtvtrhyrqhqkgketS 327

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 286 apdiaglgiANPIAQVLSAAMMLRF------SMNLTDAADAIEKAVIATLEAGVLTGEL------LPDDKRENASTTSQV 353
Cdd:PTZ00435  328 ---------TNSIASIFAWTRGLAHrakldnNQELVKFCQALERSCIETIEAGFMTKDLaicvhgSSKVTRSDYLNTEEF 398


                  ....*...
gi 1023063245 354 GDEIVKQL 361
Cdd:PTZ00435  399 IDKVAEKL 406
PLN00103 PLN00103
isocitrate dehydrogenase (NADP+); Provisional
 221-364 4.70e-03

isocitrate dehydrogenase (NADP+); Provisional


Pssm-ID: 177720  Cd Length: 410  Bit Score: 38.66  E-value: 4.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 221 DHIYIDNATMQIMKNPAQFdVMLCSNLFGDIVSDECAMMTGSMGLLASASMNEDGFGL-YEPAGGSAP------DIAGLG 293
Cdd:PLN00103  249 EHRLIDDMVAYALKSEGGY-VWACKNYDGDVQSDFLAQGFGSLGLMTSVLVCPDGKTIeAEAAHGTVTrhyrvhQKGGET 327

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1023063245 294 IANPIAQV------LSAAMMLRFSMNLTDAADAIEKAVIATLEAGVLTGELL-----PDDKRENASTTSQVGDEIVKQLM 362
Cdd:PLN00103  328 STNSIASIfawsrgLAHRAKLDGNARLLDFTEKLEAACVGTVESGKMTKDLAllihgPKVSRDQYLNTEEFIDAVAEELK 407


                  ..
gi 1023063245 363 AQ 364
Cdd:PLN00103  408 AR 409
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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