DNA Binding Domain (C-terminal) Leafy/Floricaula; This family consists of various plant development proteins which are homologs of floricaula (FLO) and Leafy (LFY) proteins which are floral meristem identity proteins. Mutations in the sequences of these proteins affect flower and leaf development. LFY is a plant-specific transcription factor (TF) essential for flower development. It is one of the few master regulators of flower development, as it integrates environmental and endogenous signals to orchestrate the whole floral network. Transcription factors such as LFY, recognize short DNA motifs primarily through their DNA-binding domain. Upon binding to short stretches of DNA called cis-elements or TF binding sites (TFBS), they regulate gene expression. This entry represents the DNA binding domain found in C-terminal of LFY proteins in plants. Structure-function studies have demonstrated that LFY binds semi-palindromic 19-bp DNA elements through its highly conserved C-terminal DBD, a unique helix-turn-helix fold that by itself dimerizes on DNA.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000354003   1 EPGEVARGKKNGLDYLFHLYEQCREFLIQVQNIAKERGEKCPTKVTNQVFRYAKKAGASYINKPKMRHYAHCYALHCLDE 80
Cdd:pfam17538  19 EPGEVARGKKNGLDYLFHLYEQCRNFLIQVQALAKERGEKCPTKVTNQVFRYAKKAGASYINKPKMRHYVHCYALHCLDE 98

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1000354003  81 DVSNELRMGFKERGENVGAWRQARYKPLVAIAARQGWDIDAIFNAHPRLSIWYV 134
Cdd:pfam17538  99 EASNALRRAFKERGENVGAWRQACYHPLVAISARHGWDIDALFAAHPRLAIWYV 152

DNA Binding Domain (C-terminal) Leafy/Floricaula; This family consists of various plant development proteins which are homologs of floricaula (FLO) and Leafy (LFY) proteins which are floral meristem identity proteins. Mutations in the sequences of these proteins affect flower and leaf development. LFY is a plant-specific transcription factor (TF) essential for flower development. It is one of the few master regulators of flower development, as it integrates environmental and endogenous signals to orchestrate the whole floral network. Transcription factors such as LFY, recognize short DNA motifs primarily through their DNA-binding domain. Upon binding to short stretches of DNA called cis-elements or TF binding sites (TFBS), they regulate gene expression. This entry represents the DNA binding domain found in C-terminal of LFY proteins in plants. Structure-function studies have demonstrated that LFY binds semi-palindromic 19-bp DNA elements through its highly conserved C-terminal DBD, a unique helix-turn-helix fold that by itself dimerizes on DNA.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000354003   1 EPGEVARGKKNGLDYLFHLYEQCREFLIQVQNIAKERGEKCPTKVTNQVFRYAKKAGASYINKPKMRHYAHCYALHCLDE 80
Cdd:pfam17538  19 EPGEVARGKKNGLDYLFHLYEQCRNFLIQVQALAKERGEKCPTKVTNQVFRYAKKAGASYINKPKMRHYVHCYALHCLDE 98

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1000354003  81 DVSNELRMGFKERGENVGAWRQARYKPLVAIAARQGWDIDAIFNAHPRLSIWYV 134
Cdd:pfam17538  99 EASNALRRAFKERGENVGAWRQACYHPLVAISARHGWDIDALFAAHPRLAIWYV 152

DNA Binding Domain (C-terminal) Leafy/Floricaula; This family consists of various plant development proteins which are homologs of floricaula (FLO) and Leafy (LFY) proteins which are floral meristem identity proteins. Mutations in the sequences of these proteins affect flower and leaf development. LFY is a plant-specific transcription factor (TF) essential for flower development. It is one of the few master regulators of flower development, as it integrates environmental and endogenous signals to orchestrate the whole floral network. Transcription factors such as LFY, recognize short DNA motifs primarily through their DNA-binding domain. Upon binding to short stretches of DNA called cis-elements or TF binding sites (TFBS), they regulate gene expression. This entry represents the DNA binding domain found in C-terminal of LFY proteins in plants. Structure-function studies have demonstrated that LFY binds semi-palindromic 19-bp DNA elements through its highly conserved C-terminal DBD, a unique helix-turn-helix fold that by itself dimerizes on DNA.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1000354003   1 EPGEVARGKKNGLDYLFHLYEQCREFLIQVQNIAKERGEKCPTKVTNQVFRYAKKAGASYINKPKMRHYAHCYALHCLDE 80
Cdd:pfam17538  19 EPGEVARGKKNGLDYLFHLYEQCRNFLIQVQALAKERGEKCPTKVTNQVFRYAKKAGASYINKPKMRHYVHCYALHCLDE 98

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1000354003  81 DVSNELRMGFKERGENVGAWRQARYKPLVAIAARQGWDIDAIFNAHPRLSIWYV 134
Cdd:pfam17538  99 EASNALRRAFKERGENVGAWRQACYHPLVAISARHGWDIDALFAAHPRLAIWYV 152