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Conserved domains on  [gi|985619846|gb|AMD26065|]
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antibiotic biosynthesis monooxygenase [Listeria monocytogenes]

Protein Classification

putative quinol monooxygenase( domain architecture ID 10003583)

monooxygenase similar to Escherichia coli quinol monooxygenase YgiN that can oxidize menadiol to menadione, may be an antibiotic biosynthesis monooxygenase involved in the biosynthesis of antibiotics, such as Streptomyces tetracenomycin-F1 monooxygenase

CATH:  3.30.70.100
EC:  1.-.-.-
Gene Ontology:  GO:0004497|GO:0017000|GO:0016491
PubMed:  16496224
SCOP:  4000637

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YgiN COG1359
Quinol monooxygenase YgiN [Energy production and conversion];
2-92 1.63e-24

Quinol monooxygenase YgiN [Energy production and conversion];


:

Pssm-ID: 440970  Cd Length: 91  Bit Score: 88.08  E-value: 1.63e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985619846  2 LHIEAQITVKKEQTEAFLQATKEVIAASRAEAGNHGYELVQSTENETVFYMLEKWADMEAIQQHNDSEHFKKFQKLAADF 81
Cdd:COG1359   1 ITVIAKLTVKPGKRDEFLAALRELVEATRAEPGCLSYELYRDPDDPNRFVLYERWEDEAALEAHLASPHFKAFLAALAPL 80

                        90
                ....*....|.
gi 985619846 82 VAKELEISVLT 92
Cdd:COG1359  81 LAEPPEVRVYE 91
 
Name Accession Description Interval E-value
YgiN COG1359
Quinol monooxygenase YgiN [Energy production and conversion];
2-92 1.63e-24

Quinol monooxygenase YgiN [Energy production and conversion];


Pssm-ID: 440970  Cd Length: 91  Bit Score: 88.08  E-value: 1.63e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985619846  2 LHIEAQITVKKEQTEAFLQATKEVIAASRAEAGNHGYELVQSTENETVFYMLEKWADMEAIQQHNDSEHFKKFQKLAADF 81
Cdd:COG1359   1 ITVIAKLTVKPGKRDEFLAALRELVEATRAEPGCLSYELYRDPDDPNRFVLYERWEDEAALEAHLASPHFKAFLAALAPL 80

                        90
                ....*....|.
gi 985619846 82 VAKELEISVLT 92
Cdd:COG1359  81 LAEPPEVRVYE 91
ABM pfam03992
Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the ...
 2-75 6.57e-21

Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue.


Pssm-ID: 427635  Cd Length: 74  Bit Score: 78.47  E-value: 6.57e-21
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 985619846   2 LHIEAQITVKKEQTEAFLQATKEVIAASRAEAGNHGYELVQSTENETVFYMLEKWADMEAIQQHNDSEHFKKFQ 75
Cdd:pfam03992  1 IVVVAEIRVKPGKAEEFEEALAELVEATRNEPGCLSYELLRSLEDPDEYVVLEVWEDEAAFEAHLQSPHFKAAH 74
PRK10486 PRK10486
(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase;
7-73 7.84e-05

(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase;


Pssm-ID: 182494  Cd Length: 96  Bit Score: 38.17  E-value: 7.84e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 985619846  7 QITVKKEQTEAFLQATKEVIAASRAEAGNHGYELVQSTENETVFYMLEKWADMEAIQQHNDSEHFKK 73
Cdd:PRK10486  7 EINVKEDKVDEFIEVFRQNHLGSIQEPGNLRFDVLQDPEVPTRFYIYEAYKDEAAVAFHKTTPHYKT 73
 
Name Accession Description Interval E-value
YgiN COG1359
Quinol monooxygenase YgiN [Energy production and conversion];
2-92 1.63e-24

Quinol monooxygenase YgiN [Energy production and conversion];


Pssm-ID: 440970  Cd Length: 91  Bit Score: 88.08  E-value: 1.63e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985619846  2 LHIEAQITVKKEQTEAFLQATKEVIAASRAEAGNHGYELVQSTENETVFYMLEKWADMEAIQQHNDSEHFKKFQKLAADF 81
Cdd:COG1359   1 ITVIAKLTVKPGKRDEFLAALRELVEATRAEPGCLSYELYRDPDDPNRFVLYERWEDEAALEAHLASPHFKAFLAALAPL 80

                        90
                ....*....|.
gi 985619846 82 VAKELEISVLT 92
Cdd:COG1359  81 LAEPPEVRVYE 91
ABM pfam03992
Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the ...
 2-75 6.57e-21

Antibiotic biosynthesis monooxygenase; This domain is found in monooxygenases involved in the biosynthesis of several antibiotics by Streptomyces species. It's occurrence as a repeat in Streptomyces coelicolor SCO1909 is suggestive that the other proteins function as multimers. There is also a conserved histidine which is likely to be an active site residue.


Pssm-ID: 427635  Cd Length: 74  Bit Score: 78.47  E-value: 6.57e-21
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 985619846   2 LHIEAQITVKKEQTEAFLQATKEVIAASRAEAGNHGYELVQSTENETVFYMLEKWADMEAIQQHNDSEHFKKFQ 75
Cdd:pfam03992  1 IVVVAEIRVKPGKAEEFEEALAELVEATRNEPGCLSYELLRSLEDPDEYVVLEVWEDEAAFEAHLQSPHFKAAH 74
HmoA COG2329
Heme-degrading monooxygenase HmoA and related ABM domain proteins [Coenzyme transport and ...
 8-96 8.85e-07

Heme-degrading monooxygenase HmoA and related ABM domain proteins [Coenzyme transport and metabolism];


Pssm-ID: 441901  Cd Length: 98  Bit Score: 43.06  E-value: 8.85e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985619846  8 ITVKKEQTEAFLQATKEVIAASRAEAGNHGYELVQSTENETVFYMLEKWADMEAIQQHNDSEHFKKFQKLAADFVAKELE 87
Cdd:COG2329   8 FRVKPGQEEEFEEAFAERRELLAEQPGFLGFELLRSLEDPGEYLVVSYWESEEAFRAWFRSSEHRAAHAKGREILAGPPR 87


                ....*....
gi 985619846 88 ISVLTPLAR 96
Cdd:COG2329  88 VEHYEVVAE 96
PRK10486 PRK10486
(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase;
7-73 7.84e-05

(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase;


Pssm-ID: 182494  Cd Length: 96  Bit Score: 38.17  E-value: 7.84e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 985619846  7 QITVKKEQTEAFLQATKEVIAASRAEAGNHGYELVQSTENETVFYMLEKWADMEAIQQHNDSEHFKK 73
Cdd:PRK10486  7 EINVKEDKVDEFIEVFRQNHLGSIQEPGNLRFDVLQDPEVPTRFYIYEAYKDEAAVAFHKTTPHYKT 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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