NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|972297206|gb|ALV86221|]
View 

arsenical pump membrane protein, partial [uncultured Herminiimonas sp.]

Protein Classification

transporter permease( domain architecture ID 229430)

transporter permease similar to ArsB/NhaD family permeases, which typically contain 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ArsB_NhaD_permease super family cl21473
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 1-248 2.88e-153

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


The actual alignment was detected with superfamily member PRK15445:

Pssm-ID: 473875  Cd Length: 427  Bit Score: 433.06  E-value: 2.88e-153
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972297206   1 VWNIVWNATGTFIAIIIISLVLDQAGFFEWAALHVARWGRGNGRMLFVLLVLLGAMVSALFANDGAALILTPIVIAMLLS 80
Cdd:PRK15445  48 VWGIVWNATLTFIAIIIISLLLDEAGFFEWAALHVARWAKGNGRKLFVYIVLLGAAVAALFANDGAALILTPIVLAMLLA 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972297206  81 LRFSPQTTLAFVMAAGFIADTASLPLVVSNLVNIVSADYFKIGFARYASVMMPVNVVSVGMTLLVLIWYFRRDIPATYDV 160
Cdd:PRK15445 128 LGFSKKATLAFVMAAGFIADTASLPLVVSNLVNIVSADYFGIGFAEYASVMVPVNLVSLAASLLVLWLYFRKDIPKTYDL 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972297206 161 QQLKKPSDAIRDRATFLAGWWVLGLLLIGFFWLEERGIPVSAVAAVGALFLLAIAAKGHVISTRNVIRHAPWQVVFFSLG 240
Cdd:PRK15445 208 ELLKEPASAIKDPALFKLGWIVLALLLVGYFVLEPLGIPVSAIAGVGALILLLVARRGHAINTKKVLKGAPWQIVIFSLG 287


                 ....*...
gi 972297206 241 MYLVVYGL 248
Cdd:PRK15445 288 MYLVVYGL 295
 
Name Accession Description Interval E-value
PRK15445 PRK15445
arsenical efflux pump membrane protein ArsB;
1-248 2.88e-153

arsenical efflux pump membrane protein ArsB;


Pssm-ID: 185342  Cd Length: 427  Bit Score: 433.06  E-value: 2.88e-153
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972297206   1 VWNIVWNATGTFIAIIIISLVLDQAGFFEWAALHVARWGRGNGRMLFVLLVLLGAMVSALFANDGAALILTPIVIAMLLS 80
Cdd:PRK15445  48 VWGIVWNATLTFIAIIIISLLLDEAGFFEWAALHVARWAKGNGRKLFVYIVLLGAAVAALFANDGAALILTPIVLAMLLA 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972297206  81 LRFSPQTTLAFVMAAGFIADTASLPLVVSNLVNIVSADYFKIGFARYASVMMPVNVVSVGMTLLVLIWYFRRDIPATYDV 160
Cdd:PRK15445 128 LGFSKKATLAFVMAAGFIADTASLPLVVSNLVNIVSADYFGIGFAEYASVMVPVNLVSLAASLLVLWLYFRKDIPKTYDL 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972297206 161 QQLKKPSDAIRDRATFLAGWWVLGLLLIGFFWLEERGIPVSAVAAVGALFLLAIAAKGHVISTRNVIRHAPWQVVFFSLG 240
Cdd:PRK15445 208 ELLKEPASAIKDPALFKLGWIVLALLLVGYFVLEPLGIPVSAIAGVGALILLLVARRGHAINTKKVLKGAPWQIVIFSLG 287


                 ....*...
gi 972297206 241 MYLVVYGL 248
Cdd:PRK15445 288 MYLVVYGL 295
2a45 TIGR00935
arsenite/antimonite efflux pump membrane protein; Members of this protein family are ArsB, a ...
 1-248 1.65e-115

arsenite/antimonite efflux pump membrane protein; Members of this protein family are ArsB, a highly hydrophobic integral membrane protein involved in transport processes used to protect cells from arsenite (or antimonite). Members of the seed alignment were selected by adjacency to the ATPase subunit ArsA that energizes the transport. [Cellular processes, Detoxification, Transport and binding proteins, Other]


Pssm-ID: 213571  Cd Length: 426  Bit Score: 337.12  E-value: 1.65e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972297206    1 VWNIVWNATGTFIAIIIISLVLDQAGFFEWAALHVARWGRGNGRMLFVLLVLLGAMVSALFANDGAALILTPIVIAMLLS 80
Cdd:TIGR00935  48 VTGIVWNATLTFVAIIIISLILDEIGFFEWAALHMARWAKGNGRKMFIYISLLGAIVAALFANDGAALILTPIVLAMVRA 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972297206   81 LRFSPQTTLAFVMAAGFIADTASLPLVVSNLVNIVSADYFKIGFARYASVMMPVNVVSVGMTLLVLIWYFRRDIPATYDV 160
Cdd:TIGR00935 128 LGFDEAAVLPFIMASGFIADTTSLPLIVSNLVNIVSADFFGIGFNEYAAVMIPPNIFALIASILVLYLYFRKDIPARYDV 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972297206  161 QQLKKPSDAIRDRATFLAGWWVLGLLLIGFFWLEERGIPVSAVAAVGALFLLAIAAKGHVISTRNVIRHAPWQVVFFSLG 240
Cdd:TIGR00935 208 SQLREPKEAIKDQKLFKFSWVVLALLLVGYFGSEFLNIPVSFVAATIALIFLVVAAKSHAVDTRKVIKGAPWNIVVFSLG 287


                  ....*...
gi 972297206  241 MYLVVYGL 248
Cdd:TIGR00935 288 MYLVVYGL 295
ArsB_permease cd01118
Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in ...
 1-248 6.18e-89

Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump (ArsAB). The ArsAB complex is similar in many ways to ATP-binding cassette transporters, which have two groups of six transmembrane-spanning helical segments and two nucleotide-binding domains. The ArsB proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life.


Pssm-ID: 238538 [Multi-domain]  Cd Length: 416  Bit Score: 269.14  E-value: 6.18e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972297206   1 VWNIVWNATGTFIAIIIISLVLDQAGFFEWAALHVARWGRGNGRMLFVLLVLLGAMVSALFANDGAALILTPIVIAMLLS 80
Cdd:cd01118   47 VWGIVWDVTLTLIGVILLSLLLDEEGFFEWVAALAARWARGSGRKLFTLIVLLGAAVTAFFANDGTALILTPIVIALLRA 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972297206  81 LRFSPQTTLAFVMAAGFIADTASLPLVVSNLVNIVSADYFKIGFARYASVMMPVNVVSVGMTLLVLIWYFRRDIPATYDV 160
Cdd:cd01118  127 LGAKKNRTLPFLYACAFIADAASLPLPISNLVNIVTAGYFGIGFTEYAALMFLPSIVSILATYVVLYLFFRRALPKRLET 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972297206 161 QQLKKPSDAIRDRATFLAGWWVLGLLLIGFFWLEERGIPVSAVAAVGALFLLAIAAKGHVISTRNVIRHAPWQVVFFSLG 240
Cdd:cd01118  207 ASVKKPSLAIKDPLLFGLAWTLLVLLVVSAFGVDILLIPPSFIAGVLALIFLLLARRGGAINPLKVLKEAPWGVLLFSLG 286


                 ....*...
gi 972297206 241 MYLVVYGL 248
Cdd:cd01118  287 LYVVVFGL 294
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
3-248 1.54e-61

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 198.81  E-value: 1.54e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972297206   3 NIVWNATGTFIAIIIISLVLDQAGFFEWAALHVARWGRGNGRMLFVLLVLLGAMVSALFANDGAALILTPIVIAMLLSLR 82
Cdd:COG1055   50 AIDWNTILFLLGMMIIVAILDESGFFEWLAIKLARRAKGSPRRLLWLLGLLTALLSAFLDNDTTALLLTPVVLAIARRLG 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972297206  83 FSPqttLAFVMAAGFIADTASLPLVVSNLVNIVSADYFKIGFARYASVMMPVNVVSVGMTLLVLIWYFRRDIPATYDVQq 162
Cdd:COG1055  130 LNP---VPFLIAIVFAANIGGAATPIGNPTNIMIASAGGLSFLDFLANLFPPSLVSLLVTLLVLYLLFRKELPAAPDLE- 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972297206 163 lKKPSDAIRDRATFLAGWWVLGLLLIGFFWLEERGIPVSAVAAVGALFLLAIAAkghvISTRNVIRHAPWQVVFFSLGMY 242
Cdd:COG1055  206 -DDPKEAIKDRRLLRISLLVLALLLVGFVLHSFLGLPPALIALLGAAVLLLLAR----VDVREVLKKVDWSTLLFFIGLF 280


                 ....*.
gi 972297206 243 LVVYGL 248
Cdd:COG1055  281 VVVGGL 286
ArsB pfam02040
Arsenical pump membrane protein;
1-248 7.61e-45

Arsenical pump membrane protein;


Pssm-ID: 460426  Cd Length: 423  Bit Score: 155.52  E-value: 7.61e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972297206    1 VWN-IVWNATGTFIAIIIISLVLDQAGFFEWAALHVARWGRGNGRMLFVLLVLLGAMVSALFANDGAALILTPIVIAMLL 79
Cdd:pfam02040  51 TVNaILAFAAIAFIAIILDNIGFDEIAAFEMAAAAKAKAAKGFGVRMFLGAILAAAFAAAGAALDGAAIILAMIRAAHFN 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972297206   80 SLRFSPQTTLAFVMAAGFIADTASLPLVVSNLVNIVSADYFKIGFARYASVMMPVNVVSVGMTLLVLIWYFRRDIPATYD 159
Cdd:pfam02040 131 AKHFFEFIIAPFFIADGFIADFTSLNFVNINLADIFHADFFDIAFIDVAPRLFSLLAFIILASIFFLKLFFKKSDLKEVD 210

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972297206  160 VQQLKKPSDAIRDRATFLAGWWVLGLLLIGFFWLEERGIPVSAVAAVGALFLLAIAAKGHVISTRNVIRHAPWQVVFFSL 239
Cdd:pfam02040 211 KPEEAIKDEAIFDLNMFILGLLIIGLFAIEFFAIEFFSIAGSIAAGFIAAAFKIAAQHSKAVHKEAPVAEAFFAIGFFSI 290


                  ....*....
gi 972297206  240 GMYLVVYGL 248
Cdd:pfam02040 291 GMGVRNAGL 299
 
Name Accession Description Interval E-value
PRK15445 PRK15445
arsenical efflux pump membrane protein ArsB;
1-248 2.88e-153

arsenical efflux pump membrane protein ArsB;


Pssm-ID: 185342  Cd Length: 427  Bit Score: 433.06  E-value: 2.88e-153
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972297206   1 VWNIVWNATGTFIAIIIISLVLDQAGFFEWAALHVARWGRGNGRMLFVLLVLLGAMVSALFANDGAALILTPIVIAMLLS 80
Cdd:PRK15445  48 VWGIVWNATLTFIAIIIISLLLDEAGFFEWAALHVARWAKGNGRKLFVYIVLLGAAVAALFANDGAALILTPIVLAMLLA 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972297206  81 LRFSPQTTLAFVMAAGFIADTASLPLVVSNLVNIVSADYFKIGFARYASVMMPVNVVSVGMTLLVLIWYFRRDIPATYDV 160
Cdd:PRK15445 128 LGFSKKATLAFVMAAGFIADTASLPLVVSNLVNIVSADYFGIGFAEYASVMVPVNLVSLAASLLVLWLYFRKDIPKTYDL 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972297206 161 QQLKKPSDAIRDRATFLAGWWVLGLLLIGFFWLEERGIPVSAVAAVGALFLLAIAAKGHVISTRNVIRHAPWQVVFFSLG 240
Cdd:PRK15445 208 ELLKEPASAIKDPALFKLGWIVLALLLVGYFVLEPLGIPVSAIAGVGALILLLVARRGHAINTKKVLKGAPWQIVIFSLG 287


                 ....*...
gi 972297206 241 MYLVVYGL 248
Cdd:PRK15445 288 MYLVVYGL 295
2a45 TIGR00935
arsenite/antimonite efflux pump membrane protein; Members of this protein family are ArsB, a ...
 1-248 1.65e-115

arsenite/antimonite efflux pump membrane protein; Members of this protein family are ArsB, a highly hydrophobic integral membrane protein involved in transport processes used to protect cells from arsenite (or antimonite). Members of the seed alignment were selected by adjacency to the ATPase subunit ArsA that energizes the transport. [Cellular processes, Detoxification, Transport and binding proteins, Other]


Pssm-ID: 213571  Cd Length: 426  Bit Score: 337.12  E-value: 1.65e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972297206    1 VWNIVWNATGTFIAIIIISLVLDQAGFFEWAALHVARWGRGNGRMLFVLLVLLGAMVSALFANDGAALILTPIVIAMLLS 80
Cdd:TIGR00935  48 VTGIVWNATLTFVAIIIISLILDEIGFFEWAALHMARWAKGNGRKMFIYISLLGAIVAALFANDGAALILTPIVLAMVRA 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972297206   81 LRFSPQTTLAFVMAAGFIADTASLPLVVSNLVNIVSADYFKIGFARYASVMMPVNVVSVGMTLLVLIWYFRRDIPATYDV 160
Cdd:TIGR00935 128 LGFDEAAVLPFIMASGFIADTTSLPLIVSNLVNIVSADFFGIGFNEYAAVMIPPNIFALIASILVLYLYFRKDIPARYDV 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972297206  161 QQLKKPSDAIRDRATFLAGWWVLGLLLIGFFWLEERGIPVSAVAAVGALFLLAIAAKGHVISTRNVIRHAPWQVVFFSLG 240
Cdd:TIGR00935 208 SQLREPKEAIKDQKLFKFSWVVLALLLVGYFGSEFLNIPVSFVAATIALIFLVVAAKSHAVDTRKVIKGAPWNIVVFSLG 287


                  ....*...
gi 972297206  241 MYLVVYGL 248
Cdd:TIGR00935 288 MYLVVYGL 295
ArsB_permease cd01118
Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in ...
 1-248 6.18e-89

Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump (ArsAB). The ArsAB complex is similar in many ways to ATP-binding cassette transporters, which have two groups of six transmembrane-spanning helical segments and two nucleotide-binding domains. The ArsB proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life.


Pssm-ID: 238538 [Multi-domain]  Cd Length: 416  Bit Score: 269.14  E-value: 6.18e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972297206   1 VWNIVWNATGTFIAIIIISLVLDQAGFFEWAALHVARWGRGNGRMLFVLLVLLGAMVSALFANDGAALILTPIVIAMLLS 80
Cdd:cd01118   47 VWGIVWDVTLTLIGVILLSLLLDEEGFFEWVAALAARWARGSGRKLFTLIVLLGAAVTAFFANDGTALILTPIVIALLRA 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972297206  81 LRFSPQTTLAFVMAAGFIADTASLPLVVSNLVNIVSADYFKIGFARYASVMMPVNVVSVGMTLLVLIWYFRRDIPATYDV 160
Cdd:cd01118  127 LGAKKNRTLPFLYACAFIADAASLPLPISNLVNIVTAGYFGIGFTEYAALMFLPSIVSILATYVVLYLFFRRALPKRLET 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972297206 161 QQLKKPSDAIRDRATFLAGWWVLGLLLIGFFWLEERGIPVSAVAAVGALFLLAIAAKGHVISTRNVIRHAPWQVVFFSLG 240
Cdd:cd01118  207 ASVKKPSLAIKDPLLFGLAWTLLVLLVVSAFGVDILLIPPSFIAGVLALIFLLLARRGGAINPLKVLKEAPWGVLLFSLG 286


                 ....*...
gi 972297206 241 MYLVVYGL 248
Cdd:cd01118  287 LYVVVFGL 294
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
3-248 1.54e-61

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 198.81  E-value: 1.54e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972297206   3 NIVWNATGTFIAIIIISLVLDQAGFFEWAALHVARWGRGNGRMLFVLLVLLGAMVSALFANDGAALILTPIVIAMLLSLR 82
Cdd:COG1055   50 AIDWNTILFLLGMMIIVAILDESGFFEWLAIKLARRAKGSPRRLLWLLGLLTALLSAFLDNDTTALLLTPVVLAIARRLG 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972297206  83 FSPqttLAFVMAAGFIADTASLPLVVSNLVNIVSADYFKIGFARYASVMMPVNVVSVGMTLLVLIWYFRRDIPATYDVQq 162
Cdd:COG1055  130 LNP---VPFLIAIVFAANIGGAATPIGNPTNIMIASAGGLSFLDFLANLFPPSLVSLLVTLLVLYLLFRKELPAAPDLE- 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972297206 163 lKKPSDAIRDRATFLAGWWVLGLLLIGFFWLEERGIPVSAVAAVGALFLLAIAAkghvISTRNVIRHAPWQVVFFSLGMY 242
Cdd:COG1055  206 -DDPKEAIKDRRLLRISLLVLALLLVGFVLHSFLGLPPALIALLGAAVLLLLAR----VDVREVLKKVDWSTLLFFIGLF 280


                 ....*.
gi 972297206 243 LVVYGL 248
Cdd:COG1055  281 VVVGGL 286
ArsB pfam02040
Arsenical pump membrane protein;
1-248 7.61e-45

Arsenical pump membrane protein;


Pssm-ID: 460426  Cd Length: 423  Bit Score: 155.52  E-value: 7.61e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972297206    1 VWN-IVWNATGTFIAIIIISLVLDQAGFFEWAALHVARWGRGNGRMLFVLLVLLGAMVSALFANDGAALILTPIVIAMLL 79
Cdd:pfam02040  51 TVNaILAFAAIAFIAIILDNIGFDEIAAFEMAAAAKAKAAKGFGVRMFLGAILAAAFAAAGAALDGAAIILAMIRAAHFN 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972297206   80 SLRFSPQTTLAFVMAAGFIADTASLPLVVSNLVNIVSADYFKIGFARYASVMMPVNVVSVGMTLLVLIWYFRRDIPATYD 159
Cdd:pfam02040 131 AKHFFEFIIAPFFIADGFIADFTSLNFVNINLADIFHADFFDIAFIDVAPRLFSLLAFIILASIFFLKLFFKKSDLKEVD 210

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972297206  160 VQQLKKPSDAIRDRATFLAGWWVLGLLLIGFFWLEERGIPVSAVAAVGALFLLAIAAKGHVISTRNVIRHAPWQVVFFSL 239
Cdd:pfam02040 211 KPEEAIKDEAIFDLNMFILGLLIIGLFAIEFFAIEFFSIAGSIAAGFIAAAFKIAAQHSKAVHKEAPVAEAFFAIGFFSI 290


                  ....*....
gi 972297206  240 GMYLVVYGL 248
Cdd:pfam02040 291 GMGVRNAGL 299
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 4-248 1.04e-35

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 130.45  E-value: 1.04e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972297206   4 IVWNATGTFIAIIIISLVLDQAGFFEWAALHVARWGRGNGRMLFVLLVLLGAMvSALFANDGAALILTPIVIAMLLSLRF 83
Cdd:cd00625   37 IDWETILLLFGMMILSAALEETGLFDRLAAKLARASKGSRRLLLLLMLLTAAL-SAFFSNDATAVLLTPIVLALLRKLGL 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972297206  84 SPqtTLAFVMAAGFIADTASLPLVVSNLVNIVSADYFKIGFARYASVMMPVNVVSVGMTLLVLIWYFRRDIPATYDVQQL 163
Cdd:cd00625  116 SP--PVPLLLALAFAANIGGAATPIGNPPNLIIASLSGLGFLDFLAFMAPPALGLLLLLLGLLYLLFRKKLLLPDEDKLT 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972297206 164 KKPSDAIRDRATFLAGWWVLGLLLIgFFWLEERGIPVSAVAAVGALFLLAIAAKGhvISTRNVIRHAPWQVVFFSLGMYL 243
Cdd:cd00625  194 VLAEPLPARPLLKKFLLLALLLLLL-FVLLFFFLIPLGLIALLGALLLLLLLVRG--LDPEEVLKSVDWGTLLFFAGLFV 270


                 ....*
gi 972297206 244 VVYGL 248
Cdd:cd00625  271 LVGAL 275
CitMHS pfam03600
Citrate transporter;
4-248 3.82e-32

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 120.11  E-value: 3.82e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972297206    4 IVWNATGTFIAIIIISLVLDQAGFFEWAALHVARWGRGNGRMLFVLLVLLGAMVSALFANDGAALILTPIVIAMLLSLRF 83
Cdd:pfam03600  37 IDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLLVALMLATALLSAFLSNDGTVLIMIPIVLALARRLGL 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972297206   84 SPqttLAFVMAAGFIADTASLPLVVSNLVNIVSADYFKIGFARYASVMMPVNVVSVGMT-LLVLIWYFRRDIPATYDVQQ 162
Cdd:pfam03600 117 PP---SPLLIALAFAANIGGTATPIGDPPNIIIASALGLSFGDFGFFMFPPVGVALLLVgLLPLLLIFRKLLPVRKEEEA 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972297206  163 LKKP--SDAIRDRATFLAGWWVLGLLLIGFFWLeergipvsavaAVGALFLLAIAAKGHVISTRNVIRHAPWQVVFFSLG 240
Cdd:pfam03600 194 ELEElrKRAIKDKLLLAISALVLALVILGFLLL-----------SVLALAGALLLLLTGVLDPEEALKAVDWSTLLFFAG 262


                  ....*...
gi 972297206  241 MYLVVYGL 248
Cdd:pfam03600 263 LFILVGAL 270
P_permease cd01116
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ...
 4-248 1.29e-18

Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.


Pssm-ID: 238536 [Multi-domain]  Cd Length: 413  Bit Score: 83.84  E-value: 1.29e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972297206   4 IVWNATGTFIAIIIISLVLDQAGFFEWAALHVARWGRGNGRMLFVLLVLLGAMVSALFANDGAALILTPIVIAM--LLSL 81
Cdd:cd01116   45 VDWETLALLLGMMIIVSILSETGVFEYLAIWAVKISKGRPWRLLLLLGLLTAFLSAFLDNVTTVLLMVPVTIRLceVLGL 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972297206  82 RFSPqttlaFVMAAGFIADTASLPLVVSNLVNIVSADYFKIGFARYASVMMPVNVVSVGMTLLVLIWYFRRDIPATYDVQ 161
Cdd:cd01116  125 NPVP-----VLISEVIAANIGGAATLIGDPPNIMIGSAAGLTFNDFLLHMLPSVVLALVVTFILLYFLYRNILKAREEDV 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972297206 162 QLK---KPSDAIRDRATFLAGWWVLGLLLIGFFWLEERGIPVSAVAAVGALFLLAIAAKGHVIstrNVIRHAPWQVVFFS 238
Cdd:cd01116  200 LALaelEPKYPIKDKVLLLKSLTILTLVIIGFVLHSPLGVSLGWIALLGALLLLLLADKLDFE---DVLSRVEWDTLLFF 276

                        250
                 ....*....|
gi 972297206 239 LGMYLVVYGL 248
Cdd:cd01116  277 AGLFVLVGGL 286
YbiR_permease cd01117
Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to ...
 4-248 1.98e-13

Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate sodium, sulfate, arsenite and organic anions. A typical ArsB/NhaD permease is composed of 8-13 transmembrane domains.


Pssm-ID: 238537 [Multi-domain]  Cd Length: 384  Bit Score: 68.84  E-value: 1.98e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972297206   4 IVWNATGTFIAIIIISLVLDQAGFFEWAALHVArWGRGNGRMLFVLLVLLGAMVSALFANDGAALILTPIVIAMLLSLRF 83
Cdd:cd01117   39 IDLDTIILLFGLMVVSAALELSGFFDALGSRIL-VKAGSPRRLLFLLVLLSGILSALLTNDTACLVFTPIVLELARVAGL 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972297206  84 SPQttlAFVMAAGFIADTASLPLVVSNLVNIVSADYFKIGFARYASVMMPVNVVSVGMTLLVLIWYFRRDIPATYDVQQL 163
Cdd:cd01117  118 PPI---PLLLALATAANIGSAATPIGNPQNLLIASESGISFPFFLAAMAPLALLGLLLLLILLLVLFPGELKGLPLDKAT 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972297206 164 KKPSDAIRDRATFLAgWWVLGLLLIGFFWLEERGIPVSAVAAVGALFLLAIAAkghvistRNVIRHAPWQVVFFSLGMYL 243
Cdd:cd01117  195 KEEGVGARKLAVKLL-VLILLLLVAFLALLGVIPLWTAALVAAVLLLLTRLKP-------RRVLKKVDWGLLLFFAGLFI 266


                 ....*
gi 972297206 244 VVYGL 248
Cdd:cd01117  267 LVGGF 271
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
13-237 3.20e-10

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 59.40  E-value: 3.20e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972297206  13 IAIIIISLVLDQAGFFEWAALHVARWGRGNGRMLFVLLVLLGAMVSALFANDGAALILTPIVIAMLLSLRFSPQTTLA-- 90
Cdd:COG0471    1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAALGSEKRSKFGsa 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972297206  91 FVMAAGFIADTASLPLVVSNLVNIVSADYFK------IGFARYASVMMPVNVVSVGMTLLVLIWYFRRDIPATYDVQQLK 164
Cdd:COG0471   81 LLLPIAFAASIGGMGTLIGTPPNLIAAGLLEeatgipISFFEWMLVGLPVALVGLLLLWLVLYRLLPPEIKEVPGSKEVI 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 972297206 165 KPSDAIRDRATFLAGWWVLGLLLIGFFWLEER--GIPVSAVAAVGALFLLAIaakgHVISTRNVIRHAPWQVVFF 237
Cdd:COG0471  161 REELAELGPLSRREKIALAIFALTVLLWITGSlhGIPIAVVALLGAVLLLLT----GVLTWKDAYKSIPWGVLLL 231
PLN00136 PLN00136
silicon transporter; Provisional
 10-172 1.76e-05

silicon transporter; Provisional


Pssm-ID: 215070 [Multi-domain]  Cd Length: 482  Bit Score: 45.37  E-value: 1.76e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972297206  10 GTFIAIIIISLVLDQAGFFEwaalHVAR---WGRGNGRMLFVLLVLLGAMVSALFANDGAALILTPIVIAmLLSLRFSPQ 86
Cdd:PLN00136  67 GLLFATMVVGSYLKNAGMFK----HLGRllaWRSQGGRDLLCRVCVVTALASALFTNDTCCVVLTEFVLE-LAAERNLPA 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972297206  87 TtlAFVMAAGFIADTASLPLVVSNLVNIVSADYFKIGFARYASVMMPVNVVSVGMTLLVLIWYFRRDIPATYDVQQLKKP 166
Cdd:PLN00136 142 K--PFLLALASSANIGSSATPIGNPQNLVIAFNSKITFPKFLLGILPAMLAGMAVNMVMLLCMYWKDLDGGAELSVDGKQ 219


                 ....*.
gi 972297206 167 SDAIRD 172
Cdd:PLN00136 220 MEAVEE 225
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
12-151 3.27e-05

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 44.37  E-value: 3.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972297206  12 FIAIIIISLVLDQAGFFEWAALHVARWGRGNGRMLFVLLVLLGAMVSALFANDGA-ALILTPIVIAMLLSLRFSPqttLA 90
Cdd:COG0471  232 FGGGLALGAALEKTGLAAWLADALLPLLGGLSPLLLLLLLALLTLLLTEFASNTAtAALLLPIAISLAQALGVNP---LP 308

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 972297206  91 FVMAAGFIADTASLpLVVSNLVNIVSADYFKIGFARYASVMMPVNVVSVGMTLLVLIWYFR 151
Cdd:COG0471  309 LALAVAFAASCAFL-LPVGTPPNAIVYGSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLWWP 368
ABG_transport pfam03806
AbgT putative transporter family;
42-150 3.61e-04

AbgT putative transporter family;


Pssm-ID: 397742  Cd Length: 502  Bit Score: 41.19  E-value: 3.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972297206   42 NGRMLFVLLVLLGAMVSALFANDGAAL-ILTPIVIAMLLSLRFSPqttlAFVMAAGFIADTASLPL--VVSN--LVNIVS 116
Cdd:pfam03806 378 PGIPLFLGFILLSAFINLLIGSASAKWaILAPIFVPMLMLLGYSP----EFTQAAYRIGDSVTNIItpMMSYfpLVLAFA 453

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 972297206  117 ADYFK-IGFARYASVMMPVNVV-SVGMTLLVLIWYF 150
Cdd:pfam03806 454 QKYDKdMGIGTLISLMLPYSIAfLIAWIALLLVWVL 489
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 2-150 1.93e-03

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 38.72  E-value: 1.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972297206   2 WNIVWNATGTfiaiIIISLVLDQAGFFEWAALHVARWGRGNGRMLFVLLVLLGAMVSALF-ANDGAALILTPIVIAMLLS 80
Cdd:cd01115  241 WGIIFLFAGG----IPLGKALESSGAAALIAEALISLLGGLPPFAILLLLCLLTLVLTNFiSNTATAVLLAPIALSIALS 316

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972297206  81 LRFSPqttLAFVMAAGFIADTASLpLVVSNLVNIVSADYFKIGFARYASVMMPVNVVSVGMTLLVLIWYF 150
Cdd:cd01115  317 LGLPP---EALLLAVAIGASCAFM-LPVGTPPNAIVLGPGGYKFSDFAKVGLPLSILSLVVSVTMIPLIW 382
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH