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Conserved domains on  [gi|959172207|gb|ALR05384|]
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2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [Xylella fastidiosa]

Protein Classification

2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase( domain architecture ID 10002734)

2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase catalyzes the pyrophosphoryl transfer from ATP to 6-hydroxymethyl-7,8-dihydropterin to form AMP and 6-hydroxymethyl-7,8-dihydropterin diphosphate

CATH:  3.30.70.560
EC:  2.7.6.3
Gene Ontology:  GO:0005524|GO:0003848|GO:0009396
SCOP:  4001325

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FolK COG0801
7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase (folate biosynthesis) [Coenzyme transport ...
 4-147 1.61e-49

7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase (folate biosynthesis) [Coenzyme transport and metabolism]; 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase (folate biosynthesis) is part of the Pathway/BioSystem: Folate biosynthesis


:

Pssm-ID: 440564  Cd Length: 155  Bit Score: 156.79  E-value: 1.61e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959172207   4 VLLSLGSNV-RPRYYLRQAEAALHAF--FGEVLFSPVYRTLAVGF-DGPDFLNSAAMVHTAMPLSDLHAWLHALEERYGR 79
Cdd:COG0801    2 VYLALGSNLgDREANLRAALEALAALpgIRVLAVSSVYETPPVGFtDQPDFLNAVVLLETDLSPEELLDALQAIEAELGR 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 959172207  80 DRAVpRFGNRTLDVDVVFYGDLIVKEPggEYCIPRREL-KHSFVLKPLVDVAPDFVDPVSGRTLAQLWA 147
Cdd:COG0801   82 VRKE-RWGPRTLDLDILLYGDLVIDTP--RLTLPHPRMhERAFVLVPLAEIAPDLVHPVLGKTVAELLA 147
 
Name Accession Description Interval E-value
FolK COG0801
7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase (folate biosynthesis) [Coenzyme transport ...
 4-147 1.61e-49

7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase (folate biosynthesis) [Coenzyme transport and metabolism]; 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase (folate biosynthesis) is part of the Pathway/BioSystem: Folate biosynthesis


Pssm-ID: 440564  Cd Length: 155  Bit Score: 156.79  E-value: 1.61e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959172207   4 VLLSLGSNV-RPRYYLRQAEAALHAF--FGEVLFSPVYRTLAVGF-DGPDFLNSAAMVHTAMPLSDLHAWLHALEERYGR 79
Cdd:COG0801    2 VYLALGSNLgDREANLRAALEALAALpgIRVLAVSSVYETPPVGFtDQPDFLNAVVLLETDLSPEELLDALQAIEAELGR 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 959172207  80 DRAVpRFGNRTLDVDVVFYGDLIVKEPggEYCIPRREL-KHSFVLKPLVDVAPDFVDPVSGRTLAQLWA 147
Cdd:COG0801   82 VRKE-RWGPRTLDLDILLYGDLVIDTP--RLTLPHPRMhERAFVLVPLAEIAPDLVHPVLGKTVAELLA 147
folK TIGR01498
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase; This model describes the ...
 4-131 1.96e-45

2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase; This model describes the folate biosynthesis enzyme 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase. Alternate names include 6-hydroxymethyl-7,8-dihydropterin diphosphokinase and 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase (HPPK). The extreme C-terminal region, of typically eight to thirty residues, is not included in the model. This enzyme may be found as a fusion protein with other enzymes of folate biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Folic acid]


Pssm-ID: 273658  Cd Length: 129  Bit Score: 145.49  E-value: 1.96e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959172207    4 VLLSLGSNVRPR-YYLRQAEAALHAFFGEVL-FSPVYRTLAVGF-DGPDFLNSAAMVHTAMPLSDLHAWLHALEERYGRD 80
Cdd:TIGR01498   1 AYIALGSNLGDRlKNLRAALAALAALPVRLLiVSSIYETPPWGFtDQPDFLNAVVEVETTLSPRELLALLQAIEAEFGRV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 959172207   81 RaVPRFGNRTLDVDVVFYGDLIVKEPGGEYCIPRRELKHsFVLKPLVDVAP 131
Cdd:TIGR01498  81 R-EFRWGPRTLDLDILLYGDEVLDTPDLTVPHPRALERP-FVLLPLAEIAP 129
HPPK cd00483
7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential ...
 4-129 9.29e-43

7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after uptake by a carrier-mediated active transport system. Most microbes and plants lack this system and must synthesize folates de novo from guanosine triphosphate. One enzyme from this pathway is HPPK which catalyzes pyrophosphoryl transfer from ATP to 6-hydroxymethyl-7,8-dihydropterin (HP). The functional enzyme is a monomer. Mammals lack many of the enzymes in the folate pathway including, HPPK.


Pssm-ID: 238269  Cd Length: 128  Bit Score: 138.77  E-value: 9.29e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959172207   4 VLLSLGSNVRPR-YYLRQAEAALHAFFG-EVL-FSPVYRTLAVGF-DGPDFLNSAAMVHTAMPLSDLHAWLHALEERYGR 79
Cdd:cd00483    1 VYLALGSNLGDRlANLRAALRALAALPGiEILaVSPLYETAPVGFtDQPDFLNAVVELETSLSPLELLDALQAIEQRLGR 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 959172207  80 DRAvPRFGNRTLDVDVVFYGDLIVKEPGgeYCIPR-RELKHSFVLKPLVDV 129
Cdd:cd00483   81 VRK-ERWGPRTLDLDILLYGDEVIDTPD--LTLPHpRMHERAFVLVPLAEI 128
HPPK pfam01288
7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK);
6-131 3.63e-37

7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK);


Pssm-ID: 460149  Cd Length: 128  Bit Score: 124.41  E-value: 3.63e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959172207    6 LSLGSNV-RPRYYLRQAEAALHAFFGEVL-FSPVYRTLAVGF-DGPDFLNSAAMVHTAMPLSDLHAWLHALEERYGRDRA 82
Cdd:pfam01288   2 LALGSNLgDREANLRAALAALAALGGKVVaVSSLYETAPVGGtDQPDFLNAVVEIETDLSPEELLDALQAIERELGRVRE 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 959172207   83 VpRFGNRTLDVDVVFYGDLIVKEPggEYCIPRREL-KHSFVLKPLVDVAP 131
Cdd:pfam01288  82 I-RWGPRTIDLDILLYGDEVIDTP--RLTLPHPRMhERAFVLVPLAEIAP 128
PRK14092 PRK14092
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase;
6-136 9.16e-19

2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase;


Pssm-ID: 172582  Cd Length: 163  Bit Score: 78.46  E-value: 9.16e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959172207   6 LSLGSNvrpryyLRQAEAALHAFFGEVLF---------SPVYRTLAVGFDGPDFLNSAAMVHTAMPLSDLHAWLHALEER 76
Cdd:PRK14092  12 VGLGAN------LGDAAATLRSVLAELAAapgilackaSRLYRTAPVDAQGPDFVNAVAALDTTLAPLDLLDLLQALEQR 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 959172207  77 YGRDRAVpRFGNRTLDVDVVFYGDLIVKEPggEYCIPRREL-KHSFVLKPLVDVAPDFVDP 136
Cdd:PRK14092  86 HGRERPY-RNAPRTLDLDLLLYGEQAIDHP--RLSVPHPRMhERAFVLAPLCELAPALRLA 143
 
Name Accession Description Interval E-value
FolK COG0801
7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase (folate biosynthesis) [Coenzyme transport ...
 4-147 1.61e-49

7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase (folate biosynthesis) [Coenzyme transport and metabolism]; 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase (folate biosynthesis) is part of the Pathway/BioSystem: Folate biosynthesis


Pssm-ID: 440564  Cd Length: 155  Bit Score: 156.79  E-value: 1.61e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959172207   4 VLLSLGSNV-RPRYYLRQAEAALHAF--FGEVLFSPVYRTLAVGF-DGPDFLNSAAMVHTAMPLSDLHAWLHALEERYGR 79
Cdd:COG0801    2 VYLALGSNLgDREANLRAALEALAALpgIRVLAVSSVYETPPVGFtDQPDFLNAVVLLETDLSPEELLDALQAIEAELGR 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 959172207  80 DRAVpRFGNRTLDVDVVFYGDLIVKEPggEYCIPRREL-KHSFVLKPLVDVAPDFVDPVSGRTLAQLWA 147
Cdd:COG0801   82 VRKE-RWGPRTLDLDILLYGDLVIDTP--RLTLPHPRMhERAFVLVPLAEIAPDLVHPVLGKTVAELLA 147
folK TIGR01498
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase; This model describes the ...
 4-131 1.96e-45

2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase; This model describes the folate biosynthesis enzyme 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase. Alternate names include 6-hydroxymethyl-7,8-dihydropterin diphosphokinase and 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase (HPPK). The extreme C-terminal region, of typically eight to thirty residues, is not included in the model. This enzyme may be found as a fusion protein with other enzymes of folate biosynthesis. [Biosynthesis of cofactors, prosthetic groups, and carriers, Folic acid]


Pssm-ID: 273658  Cd Length: 129  Bit Score: 145.49  E-value: 1.96e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959172207    4 VLLSLGSNVRPR-YYLRQAEAALHAFFGEVL-FSPVYRTLAVGF-DGPDFLNSAAMVHTAMPLSDLHAWLHALEERYGRD 80
Cdd:TIGR01498   1 AYIALGSNLGDRlKNLRAALAALAALPVRLLiVSSIYETPPWGFtDQPDFLNAVVEVETTLSPRELLALLQAIEAEFGRV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 959172207   81 RaVPRFGNRTLDVDVVFYGDLIVKEPGGEYCIPRRELKHsFVLKPLVDVAP 131
Cdd:TIGR01498  81 R-EFRWGPRTLDLDILLYGDEVLDTPDLTVPHPRALERP-FVLLPLAEIAP 129
HPPK cd00483
7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential ...
 4-129 9.29e-43

7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after uptake by a carrier-mediated active transport system. Most microbes and plants lack this system and must synthesize folates de novo from guanosine triphosphate. One enzyme from this pathway is HPPK which catalyzes pyrophosphoryl transfer from ATP to 6-hydroxymethyl-7,8-dihydropterin (HP). The functional enzyme is a monomer. Mammals lack many of the enzymes in the folate pathway including, HPPK.


Pssm-ID: 238269  Cd Length: 128  Bit Score: 138.77  E-value: 9.29e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959172207   4 VLLSLGSNVRPR-YYLRQAEAALHAFFG-EVL-FSPVYRTLAVGF-DGPDFLNSAAMVHTAMPLSDLHAWLHALEERYGR 79
Cdd:cd00483    1 VYLALGSNLGDRlANLRAALRALAALPGiEILaVSPLYETAPVGFtDQPDFLNAVVELETSLSPLELLDALQAIEQRLGR 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 959172207  80 DRAvPRFGNRTLDVDVVFYGDLIVKEPGgeYCIPR-RELKHSFVLKPLVDV 129
Cdd:cd00483   81 VRK-ERWGPRTLDLDILLYGDEVIDTPD--LTLPHpRMHERAFVLVPLAEI 128
HPPK pfam01288
7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK);
6-131 3.63e-37

7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK);


Pssm-ID: 460149  Cd Length: 128  Bit Score: 124.41  E-value: 3.63e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959172207    6 LSLGSNV-RPRYYLRQAEAALHAFFGEVL-FSPVYRTLAVGF-DGPDFLNSAAMVHTAMPLSDLHAWLHALEERYGRDRA 82
Cdd:pfam01288   2 LALGSNLgDREANLRAALAALAALGGKVVaVSSLYETAPVGGtDQPDFLNAVVEIETDLSPEELLDALQAIERELGRVRE 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 959172207   83 VpRFGNRTLDVDVVFYGDLIVKEPggEYCIPRREL-KHSFVLKPLVDVAP 131
Cdd:pfam01288  82 I-RWGPRTIDLDILLYGDEVIDTP--RLTLPHPRMhERAFVLVPLAEIAP 128
PRK14092 PRK14092
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase;
6-136 9.16e-19

2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase;


Pssm-ID: 172582  Cd Length: 163  Bit Score: 78.46  E-value: 9.16e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 959172207   6 LSLGSNvrpryyLRQAEAALHAFFGEVLF---------SPVYRTLAVGFDGPDFLNSAAMVHTAMPLSDLHAWLHALEER 76
Cdd:PRK14092  12 VGLGAN------LGDAAATLRSVLAELAAapgilackaSRLYRTAPVDAQGPDFVNAVAALDTTLAPLDLLDLLQALEQR 85

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 959172207  77 YGRDRAVpRFGNRTLDVDVVFYGDLIVKEPggEYCIPRREL-KHSFVLKPLVDVAPDFVDP 136
Cdd:PRK14092  86 HGRERPY-RNAPRTLDLDLLLYGEQAIDHP--RLSVPHPRMhERAFVLAPLCELAPALRLA 143
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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