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Conserved domains on  [gi|951709062|gb|ALN82974|]
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bacterial regulatory, gntR family protein [Lysobacter antibioticus]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11450764)

GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain

Gene Ontology:  GO:0003677|GO:0003700
PubMed:  2060763|26172911|33509775|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
15-247 5.03e-80

DNA-binding transcriptional regulator, GntR family [Transcription];


:

Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 240.15  E-value: 5.03e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951709062  15 ARRAPAYQHLRRSLQHAIENGELTAGQALPGERELGKLLDLSRVTVRKAIAGLVADGLLVQRQGAGTFVAE-RIVKSFSR 93
Cdd:COG2188    1 SSPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEpKIEYPLSR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951709062  94 LTSFTDDLRARGLDPRSTFLERSLGEVTPEEAMALNLSPGAGVIRYYRLRTADGVALALERTVVPASV---IAHPDFVEN 170
Cdd:COG2188   81 LTSFTEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALfpgLLEEDLETG 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 951709062 171 SLYEAFAK-LGIRPARALQRLRAIAFDAEQARLMNLPEGAPGLFIERRTFLDDGRVVEFTRSFYRGDAYDFVAELQSE 247
Cdd:COG2188  161 SLYELLEErYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVELRRR 238
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
15-247 5.03e-80

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 240.15  E-value: 5.03e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951709062  15 ARRAPAYQHLRRSLQHAIENGELTAGQALPGERELGKLLDLSRVTVRKAIAGLVADGLLVQRQGAGTFVAE-RIVKSFSR 93
Cdd:COG2188    1 SSPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEpKIEYPLSR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951709062  94 LTSFTDDLRARGLDPRSTFLERSLGEVTPEEAMALNLSPGAGVIRYYRLRTADGVALALERTVVPASV---IAHPDFVEN 170
Cdd:COG2188   81 LTSFTEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALfpgLLEEDLETG 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 951709062 171 SLYEAFAK-LGIRPARALQRLRAIAFDAEQARLMNLPEGAPGLFIERRTFLDDGRVVEFTRSFYRGDAYDFVAELQSE 247
Cdd:COG2188  161 SLYELLEErYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVELRRR 238
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 103-239 6.15e-38

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 129.64  E-value: 6.15e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951709062  103 ARGLDPRSTFLERSLGEVTPEEAMALNLSPGAGVIRYYRLRTADGVALALERTVVPASVIAHP---DFVENSLYEAF-AK 178
Cdd:pfam07702   1 AQGREPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDLleeDLEEGSLYDYLeER 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 951709062  179 LGIRPARALQRLRAIAFDAEQARLMNLPEGAPGLFIERRTFLDDGRVVEFTRSFYRGDAYD 239
Cdd:pfam07702  81 YGLPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGDRYR 141
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 103-239 1.44e-35

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 123.56  E-value: 1.44e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951709062   103 ARGLDPRSTFLERSLGEVTPEEAMALNLSPGAGVIRYYRLRTADGVALALERTVVPASVIAH--PDFVENSLYEAFAK-- 178
Cdd:smart00866   1 AQGRKPTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGllEEDLSGSLYEYLEErl 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 951709062   179 --LGIRPARALQRLRAIAFDAEQARLMNLPEGAPGLFIERRTFLDDGRVVEFTRSFYRGDAYD 239
Cdd:smart00866  81 glKIVRSTRAEQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGDRFR 143
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 21-243 1.29e-26

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 103.32  E-value: 1.29e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951709062   21 YQHLRRSLQHAIENGELTAGQALPGERELGKLLDLSRVTVRKAIAGLVADGLLVQRQGAGTFV-AERIVKSFSRLTSFTD 99
Cdd:TIGR02325  10 WRQIADKIEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVaARRIDYPLSARTRFSQ 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951709062  100 DLRARGLDPRSTFLERSLGEVTPEEAMALNLSPGAGVIRYYRLRTADGVALALERTVVPASVI--AHPDFVEN-SLYEAF 176
Cdd:TIGR02325  90 NLADQGREPTGELLLSDLEPASAELADALGLTVGAPLVRLETLRKADGRPLCRATTWFPAARFpgIGQAYAASgSITDAL 169

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 951709062  177 AKLGIRPARALQ-RLRAIAFDAEQARLMNLPEGAPGLFIERRTFLDDGRVVEFTRSFYRGDAYDFVAE 243
Cdd:TIGR02325 170 REQGVADYRRSStRISARHADAKDCARLELPPGRPLLVVQALNHDGEGRPVQYSVSRFRADRVEFTME 237
PRK09764 PRK09764
GntR family transcriptional regulator;
17-240 6.53e-26

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 101.44  E-value: 6.53e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951709062  17 RAPAYQHLRRSLQHAIENGELTAGQALPGERELGKLLDLSRVTVRKAIAGLVADGLLVQRQGAGTFVAE-RIVKSFSRLT 95
Cdd:PRK09764   3 HKPLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEeRVNYDIFQLT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951709062  96 SFTDDLRARGLDPRSTFLersLGEVTP-EEAMA--LNLSPGAGVIRYYRLRTADGVALALERTVVPASVIahPDF----V 168
Cdd:PRK09764  83 SFDEKLSDRHVDTHSEVL---IFEVIPaDDFLQqqLQITAQDRVWHVKRVRYRKQKPMALEETWMPLALF--PDLtwqvM 157

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 951709062 169 ENSLY---EAFAKLGIRpaRALQRLRAIAFDAEQARLMNLPEGAPGLFIERRTFLDDGRVVEFTRSFYRGDAYDF 240
Cdd:PRK09764 158 ENSKYhfiEEVKKMVID--RSEQEIIPLMPTEEMSRLLNISQTKPILEKVSRGYLVDGRVFEYSRNAFNTDDYKF 230
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 19-84 1.32e-19

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 79.80  E-value: 1.32e-19
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 951709062  19 PAYQHLRRSLQHAIENGELTAGQALPGERELGKLLDLSRVTVRKAIAGLVADGLLVQRQGAGTFVA 84
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
 
Name Accession Description Interval E-value
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
15-247 5.03e-80

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 240.15  E-value: 5.03e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951709062  15 ARRAPAYQHLRRSLQHAIENGELTAGQALPGERELGKLLDLSRVTVRKAIAGLVADGLLVQRQGAGTFVAE-RIVKSFSR 93
Cdd:COG2188    1 SSPVPLYLQIADALRERIESGELPPGDRLPSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAEpKIEYPLSR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951709062  94 LTSFTDDLRARGLDPRSTFLERSLGEVTPEEAMALNLSPGAGVIRYYRLRTADGVALALERTVVPASV---IAHPDFVEN 170
Cdd:COG2188   81 LTSFTEELRARGREPSTRVLSAERVPADEEVAEALGLPPGAPVLRIERLRLADGEPVALETSYLPAALfpgLLEEDLETG 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 951709062 171 SLYEAFAK-LGIRPARALQRLRAIAFDAEQARLMNLPEGAPGLFIERRTFLDDGRVVEFTRSFYRGDAYDFVAELQSE 247
Cdd:COG2188  161 SLYELLEErYGLRITRAEQRIEAVLADAEEAELLGVPPGAPVLVIERVTYDADGRPVEYSRSYYRGDRYRFVVELRRR 238
UTRA pfam07702
UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ...
 103-239 6.15e-38

UTRA domain; The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to pfam04345. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules sugar phosphates and urocanate, Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 429607 [Multi-domain]  Cd Length: 141  Bit Score: 129.64  E-value: 6.15e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951709062  103 ARGLDPRSTFLERSLGEVTPEEAMALNLSPGAGVIRYYRLRTADGVALALERTVVPASVIAHP---DFVENSLYEAF-AK 178
Cdd:pfam07702   1 AQGREPKTEVLSLEEVPASAEIAEALGLPPGEPVYRIERLRYADGEPVALEEDYLPAELVPDLleeDLEEGSLYDYLeER 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 951709062  179 LGIRPARALQRLRAIAFDAEQARLMNLPEGAPGLFIERRTFLDDGRVVEFTRSFYRGDAYD 239
Cdd:pfam07702  81 YGLPITRAEQTIEAVLADAEEAELLGISPGAPVLLIERVTYDQDGRPVEYSRSYYRGDRYR 141
UTRA smart00866
The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; ...
 103-239 1.44e-35

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; It has a similar fold to HutC/FarR-like bacterial transcription factors of the GntR family. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.


Pssm-ID: 214869 [Multi-domain]  Cd Length: 143  Bit Score: 123.56  E-value: 1.44e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951709062   103 ARGLDPRSTFLERSLGEVTPEEAMALNLSPGAGVIRYYRLRTADGVALALERTVVPASVIAH--PDFVENSLYEAFAK-- 178
Cdd:smart00866   1 AQGRKPTTKVLSFERVPADEELAEALGLPPGDPVYRIERLRLADGEPVALETTYLPAALFPGllEEDLSGSLYEYLEErl 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 951709062   179 --LGIRPARALQRLRAIAFDAEQARLMNLPEGAPGLFIERRTFLDDGRVVEFTRSFYRGDAYD 239
Cdd:smart00866  81 glKIVRSTRAEQTITAVLADEEEAELLGLPPGAPLLVVERVTYDDDGRPVEYSRSYYRGDRFR 143
C_P_lyase_phnF TIGR02325
phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for ...
 21-243 1.29e-26

phosphonates metabolism transcriptional regulator PhnF; All members of the seed alignment for this family are predicted helix-turn-helix transcriptional regulatory proteins of the broader gntR and are found associated with genes for the import and degradation of phosphonates and/or related compounds (e.g. phosphonites) with a direct C-P bond. [Transport and binding proteins, Anions, Regulatory functions, DNA interactions]


Pssm-ID: 131378 [Multi-domain]  Cd Length: 238  Bit Score: 103.32  E-value: 1.29e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951709062   21 YQHLRRSLQHAIENGELTAGQALPGERELGKLLDLSRVTVRKAIAGLVADGLLVQRQGAGTFV-AERIVKSFSRLTSFTD 99
Cdd:TIGR02325  10 WRQIADKIEQEIAAGHLRAGDYLPAEMQLAERFGVNRHTVRRAIAALVERGLLRAEQGRGTFVaARRIDYPLSARTRFSQ 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951709062  100 DLRARGLDPRSTFLERSLGEVTPEEAMALNLSPGAGVIRYYRLRTADGVALALERTVVPASVI--AHPDFVEN-SLYEAF 176
Cdd:TIGR02325  90 NLADQGREPTGELLLSDLEPASAELADALGLTVGAPLVRLETLRKADGRPLCRATTWFPAARFpgIGQAYAASgSITDAL 169

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 951709062  177 AKLGIRPARALQ-RLRAIAFDAEQARLMNLPEGAPGLFIERRTFLDDGRVVEFTRSFYRGDAYDFVAE 243
Cdd:TIGR02325 170 REQGVADYRRSStRISARHADAKDCARLELPPGRPLLVVQALNHDGEGRPVQYSVSRFRADRVEFTME 237
PRK09764 PRK09764
GntR family transcriptional regulator;
17-240 6.53e-26

GntR family transcriptional regulator;


Pssm-ID: 182065 [Multi-domain]  Cd Length: 240  Bit Score: 101.44  E-value: 6.53e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951709062  17 RAPAYQHLRRSLQHAIENGELTAGQALPGERELGKLLDLSRVTVRKAIAGLVADGLLVQRQGAGTFVAE-RIVKSFSRLT 95
Cdd:PRK09764   3 HKPLYRQIADRIREQIARGELKPGDALPTESALQTEFGVSRVTVRQALRQLVEQQILESIQGSGTYVKEeRVNYDIFQLT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951709062  96 SFTDDLRARGLDPRSTFLersLGEVTP-EEAMA--LNLSPGAGVIRYYRLRTADGVALALERTVVPASVIahPDF----V 168
Cdd:PRK09764  83 SFDEKLSDRHVDTHSEVL---IFEVIPaDDFLQqqLQITAQDRVWHVKRVRYRKQKPMALEETWMPLALF--PDLtwqvM 157

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 951709062 169 ENSLY---EAFAKLGIRpaRALQRLRAIAFDAEQARLMNLPEGAPGLFIERRTFLDDGRVVEFTRSFYRGDAYDF 240
Cdd:PRK09764 158 ENSKYhfiEEVKKMVID--RSEQEIIPLMPTEEMSRLLNISQTKPILEKVSRGYLVDGRVFEYSRNAFNTDDYKF 230
PRK11402 PRK11402
transcriptional regulator PhoB;
19-240 7.71e-23

transcriptional regulator PhoB;


Pssm-ID: 183118 [Multi-domain]  Cd Length: 241  Bit Score: 93.36  E-value: 7.71e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951709062  19 PAYQHLRRSLQHAIENGELTAGQALPGERELGKLLDLSRVTVRKAIAGLVADGLLVQRQGAGTFVAERIVK-SFSRLTSF 97
Cdd:PRK11402   9 LLYATVRQRLLDDIAQGVYQAGQQIPTENELCTQYNVSRITIRKAISDLVADGVLIRWQGKGTFVQSQKVEnALLTVSGF 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951709062  98 TDDLRARGLDPRSTFLERSLgEVTPEEAMALNLSPGAGVIRYYRLRTADGVALALERTVVPASVIAHPD-FVEN--SLYE 174
Cdd:PRK11402  89 TDFGVSQGKATKEKVIEQER-VSAAPFCEKLNIPGNSEVFHLCRVMYLDKEPLFIDSSWIPLSRYPDFDeIYVEgsSTYQ 167

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 951709062 175 AFA-KLGIRPARALQRLRAIAFDAEQARLMNLPEGAPGLFIERRTFLDDGRVVEFTRSFYRGDAYDF 240
Cdd:PRK11402 168 LFQeRFDTRVVSDKKTIDIFAATRPEAKWLKCELGEPLFRISKIAFDQNDKPVHVSELFCRANRVTL 234
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 19-84 1.32e-19

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 79.80  E-value: 1.32e-19
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 951709062  19 PAYQHLRRSLQHAIENGELTAGQALPGERELGKLLDLSRVTVRKAIAGLVADGLLVQRQGAGTFVA 84
Cdd:cd07377    1 PLYEQIADQLREAILSGELKPGDRLPSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
15-107 2.96e-16

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 75.36  E-value: 2.96e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951709062  15 ARRAPAYQHLRRSLQHAIENGELTAGQALPGERELGKLLDLSRVTVRKAIAGLVADGLLVQRQGAGTFVAERIVKSFSRL 94
Cdd:COG2186    3 IRRRSLAEQVAEQLRELILSGELKPGDRLPSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSPWALLDP 82

                         90
                 ....*....|...
gi 951709062  95 TSFTDDLRARGLD 107
Cdd:COG2186   83 LALLLALDDASLR 95
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
19-132 5.68e-16

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 71.36  E-value: 5.68e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951709062  19 PAYQHLRRSLQHAIENGELTAGQALPGERELGKLLDLSRVTVRKAIAGLVADGLLVQRQGAGTFVAErivksfsrltsft 98
Cdd:COG1725   10 PIYEQIADQIKEAIASGELKPGDRLPSVRELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVAE------------- 76

                         90       100       110
                 ....*....|....*....|....*....|....
gi 951709062  99 dDLRARGLDPRSTFLERSLGEVTpEEAMALNLSP 132
Cdd:COG1725   77 -DARELLEERREEFLEEALRELV-AEARRLGLSL 108
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 15-86 6.04e-16

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 76.41  E-value: 6.04e-16
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 951709062  15 ARRAPAYQHLRRSLQHAIENGELTAGQALPGERELGKLLDLSRVTVRKAIAGLVADGLLVQRQGAGTFVAER 86
Cdd:COG1167    8 DSSGPLYLQLADALREAILSGRLPPGDRLPSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVAAR 79
PRK14999 PRK14999
histidine utilization repressor; Provisional
 9-238 6.41e-15

histidine utilization repressor; Provisional


Pssm-ID: 184961 [Multi-domain]  Cd Length: 241  Bit Score: 71.89  E-value: 6.41e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951709062   9 FRRQSDARRAPAYQHLRRSLQHAIENGELTAGQALPGERELGKLLDLSRVTVRKAIAGLVADGLLVQRQGAGTFVAERIV 88
Cdd:PRK14999   2 YSSRSRSAPAPFYETVKQDICKKIAGGVWQPHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFVAEPKG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951709062  89 KS-FSRLTSFTDDLRARGLDPRSTFLERSLGEVTPEEAMALNLSPGAGVIRYYRLRTADGVALALERTVVPASVIahPDF 167
Cdd:PRK14999  82 QSaLFEVRSIAEEIAARRHQHRCEVLTLERVRANAIQASALNVNESDVIFHSIMVHYENDLPVQIEDRCVNADIA--VDY 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 951709062 168 VENSLYE----AFAKLGIRPARALQRLRAIAFDAEQARLMNLPEGAPGLFIERRTFlDDGRVVEFTRSFYRGDAY 238
Cdd:PRK14999 160 LTQDYRQttphAYLSRIAPLTEGEHIVEAVRATAQECAWLTIKEHEPCLLIRRTTW-SASRIVSHARLLFPGSRY 233
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
28-92 1.56e-14

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 70.82  E-value: 1.56e-14
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 951709062  28 LQHAIENGELTAGQALPGERELGKLLDLSRVTVRKAIAGLVADGLLVQRQGAGTFVAERIVKSFS 92
Cdd:PRK09464  19 LEFLILEGTLRPGEKLPPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQSSLWQSFS 83
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 21-83 9.58e-14

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 64.17  E-value: 9.58e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 951709062   21 YQHLRRSLQHAIENGELTAGQALPGERELGKLLDLSRVTVRKAIAGLVADGLLVQRQGAGTFV 83
Cdd:pfam00392   2 YEQVYARLREDILSGRLRPGDKLPSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
26-83 5.97e-13

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 61.82  E-value: 5.97e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 951709062    26 RSLQHAIENGELTAGQALPGERELGKLLDLSRVTVRKAIAGLVADGLLVQRQGAGTFV 83
Cdd:smart00345   3 ERLREDIVSGELRPGDKLPSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
PRK10079 PRK10079
phosphonate metabolism transcriptional regulator PhnF; Provisional
 21-243 1.98e-12

phosphonate metabolism transcriptional regulator PhnF; Provisional


Pssm-ID: 182227 [Multi-domain]  Cd Length: 241  Bit Score: 64.80  E-value: 1.98e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951709062  21 YQHLRRSLQHAIEnGELTAGQALPGERELGKLLDLSRVTVRKAIAGLVADGLLVQRQGAGTFVAER-IVKSFSRLTSFTD 99
Cdd:PRK10079  14 YQEIAAKLEQELR-QHYRCGDYLPAEQQLAARYEVNRHTLRRAIDQLVEKGWVQRRQGVGVLVLMRpYDYPLNAQARFSQ 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951709062 100 DLRARGLDPRSTFLERSLGEVTPEEAMALNLSPGAGVIRYYRLRTADGvalalertvVPASVIAH--PD---------FV 168
Cdd:PRK10079  93 NLLDQGSHPTSEKLLSVLRPASGHVADALGITEGENVIHLRTLRRVNG---------VALCLIDHyfADltwwptlqrFD 163

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 951709062 169 ENSLYEAFAK-LGIRPARALQRLRAIAFDAEQARLMNLPEGAPGLFIerRTF---LDDGRVVEFTRSFYRGDAYDFVAE 243
Cdd:PRK10079 164 SGSLHDFLREqLGIALRRSQTRISARRAQAKESQLLEIPNMSPLLCV--RTLnhrDGESSPAEYSVSLTRADMIEFTME 240
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
 23-83 4.00e-10

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 58.24  E-value: 4.00e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 951709062  23 HLRRSLQHAIENGELTAGQALPGERELGKLLDLSRVTVRKAIAGLVADGLLVQRQGAGTFV 83
Cdd:PRK10421   6 EVADRVRALIEEKNLEAGMKLPAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFI 66
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
11-85 5.80e-08

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 51.85  E-value: 5.80e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 951709062  11 RQSDARRAPAYQHLRRSLQHAIENGELTAGQALPgERELGKLLDLSRVTVRKAIAGLVADGLLVQRQGAGTFVAE 85
Cdd:COG1802    3 SPSPLRRESLAEQVYEALREAILSGELPPGERLS-EAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAP 76
PRK11523 PRK11523
transcriptional regulator ExuR;
13-83 4.72e-07

transcriptional regulator ExuR;


Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 49.46  E-value: 4.72e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 951709062  13 SDARRApaYQHLRRSLQHAIENGELTAGQALPGERELGKLLDLSRVTVRKAIAGLVADGLLVQRQGAGTFV 83
Cdd:PRK11523   4 TEPRRL--YQQLAAELKERIEQGVYLVGDKLPAERFIADEKNVSRTVVREAIIMLEVEGYVEVRKGSGIHV 72
PRK10225 PRK10225
Uxu operon transcriptional regulator;
11-85 1.05e-06

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 48.48  E-value: 1.05e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 951709062  11 RQSDARRAPaYQHLRRSLQHAIENGELTAGQALPGERELGKLLDLSRVTVRKAIAGLVADGLLVQRQGAGTFVAE 85
Cdd:PRK10225   2 KSATSAQRP-YQEVGAMIRDLIIKTPYNPGERLPPEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVLD 75
PRK09990 PRK09990
DNA-binding transcriptional regulator GlcC; Provisional
 12-85 5.97e-05

DNA-binding transcriptional regulator GlcC; Provisional


Pssm-ID: 182186 [Multi-domain]  Cd Length: 251  Bit Score: 43.22  E-value: 5.97e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 951709062  12 QSDARRAPAYQHLRRsLQHAIENGELTAGQALPGERELGKLLDLSRVTVRKAIAGLVADGLLVQRQGAGTFVAE 85
Cdd:PRK09990   1 MKDERRPIADVVAER-IERLIVDGVLKVGQALPSERRLCEKLGFSRSALREGLTVLRGRGIIETAQGRGSFVAR 73
PRK15481 PRK15481
transcriptional regulatory protein PtsJ; Provisional
 27-87 7.13e-04

transcriptional regulatory protein PtsJ; Provisional


Pssm-ID: 185378 [Multi-domain]  Cd Length: 431  Bit Score: 40.41  E-value: 7.13e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 951709062  27 SLQHAIENGELTAGQALPGERELGKLLDLSRVTVRKAIAGLVADGLLVQRQGAGTFVAERI 87
Cdd:PRK15481  13 SIRQLIQAGRLRPGDSLPPVRELASELGVNRNTVAAAYKRLVTAGLAQSQGRNGTVIRGSP 73
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
 16-85 2.03e-03

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 38.46  E-value: 2.03e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 951709062  16 RRAPAYQHLRRSLQHAIENGELTAGQALPGERELGKLLDLSRVTVRKAIAGLVADGLL---------VQRQGAGTFVAE 85
Cdd:PRK03837  10 ARKKLSEEVEERLEQMIRSGEFGPGDQLPSERELMAFFGVGRPAVREALQALKRKGLVqishgerarVSRPSADTIIGQ 88
HTH_51 pfam18558
Helix-turn-helix domain; This is helix turn helix domain found in polyketide synthases (PKSs) ...
 174-229 9.40e-03

Helix-turn-helix domain; This is helix turn helix domain found in polyketide synthases (PKSs) in fungi. They are multidomain enzymes that biosynthesize a wide range of natural products. Family members include citrinin polyketide synthases which contain a C-methyltransferase (CMeT) domain pfam08242 that adds one or more S-adenosylmethionine (SAM)-derived methyl groups to the carbon framework.


Pssm-ID: 465801  Cd Length: 90  Bit Score: 34.36  E-value: 9.40e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 951709062  174 EAFAKLG--IRPARALQRLRAIAFDAEQARLMNLpegapgLFierrTFLDDGRVVEFT 229
Cdd:pfam18558  38 EAFEKLGcdLRSAKPGQKLPRIPHLPKHQRLVDY------LY----EILEDARLVDID 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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