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Conserved domains on  [gi|938165513|gb|ALJ22153|]
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transcriptional regulator [Microbacterium sp. No. 7]

Protein Classification

ROK family protein( domain architecture ID 11449187)

ROK (Repressor, ORF, Kinase) family protein functions as a sugar kinase or may act as a transcriptional regulator involved in carbohydrate-dependent transcriptional control

CATH:  3.30.420.40
Gene Ontology:  GO:0005524
PubMed:  20512568|17979299
SCOP:  3000092|4000330

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NagC COG1940
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ...
 81-337 2.94e-34

Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];


:

Pssm-ID: 441543 [Multi-domain]  Cd Length: 306  Bit Score: 128.86  E-value: 2.94e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513  81 REDAGVLVGVDAGHAHLTAVVTDLRSQRLGiRRTTRQVDRDDAADRRAAIADLVDDALRAAGRTRADVLALCVGVPAPVD 160
Cdd:COG1940    1 NPDAGYVIGIDIGGTKIKAALVDLDGEVLA-RERIPTPAGAGPEAVLEAIAELIEELLAEAGISRGRILGIGIGVPGPVD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513 161 -ESGR---SPHHRHlfWDRMNpgLADVFRAWAPL-VRVDNDASLAAVAEGSVGAAVGCRSYIALLAGERLGSGVVIDGNL 235
Cdd:COG1940   80 pETGVvlnAPNLPG--WRGVP--LAELLEERLGLpVFVENDANAAALAEAWFGAGRGADNVVYLTLGTGIGGGIVINGKL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513 236 LRGAHGGVGEM----VAFD----------HVEGVGTARGLGTRAAEWaleaiergdvtgplaaIPRDRLDGQAVIELASQ 301
Cdd:COG1940  156 LRGANGNAGEIghmpVDPDgplcgcgnrgCLETYASGPALLRRAREL----------------GGAEKLTAEELFAAARA 219

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 938165513 302 GDPDAQRIVHRVGVVLARIVATLGSMFDPERVVVTG 337
Cdd:COG1940  220 GDPLALEVLDEAARYLGIGLANLINLLDPEVIVLGG 255
 
Name Accession Description Interval E-value
NagC COG1940
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ...
 81-337 2.94e-34

Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];


Pssm-ID: 441543 [Multi-domain]  Cd Length: 306  Bit Score: 128.86  E-value: 2.94e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513  81 REDAGVLVGVDAGHAHLTAVVTDLRSQRLGiRRTTRQVDRDDAADRRAAIADLVDDALRAAGRTRADVLALCVGVPAPVD 160
Cdd:COG1940    1 NPDAGYVIGIDIGGTKIKAALVDLDGEVLA-RERIPTPAGAGPEAVLEAIAELIEELLAEAGISRGRILGIGIGVPGPVD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513 161 -ESGR---SPHHRHlfWDRMNpgLADVFRAWAPL-VRVDNDASLAAVAEGSVGAAVGCRSYIALLAGERLGSGVVIDGNL 235
Cdd:COG1940   80 pETGVvlnAPNLPG--WRGVP--LAELLEERLGLpVFVENDANAAALAEAWFGAGRGADNVVYLTLGTGIGGGIVINGKL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513 236 LRGAHGGVGEM----VAFD----------HVEGVGTARGLGTRAAEWaleaiergdvtgplaaIPRDRLDGQAVIELASQ 301
Cdd:COG1940  156 LRGANGNAGEIghmpVDPDgplcgcgnrgCLETYASGPALLRRAREL----------------GGAEKLTAEELFAAARA 219

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 938165513 302 GDPDAQRIVHRVGVVLARIVATLGSMFDPERVVVTG 337
Cdd:COG1940  220 GDPLALEVLDEAARYLGIGLANLINLLDPEVIVLGG 255
ASKHA_ATPase_ROK_CYANR cd24073
ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; ...
 96-337 1.89e-27

ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; CYANR acts as transcriptional repressor of cyclobis-(1-6)-alpha-nigerosyl (CNN) degrading enzymes. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466923 [Multi-domain]  Cd Length: 304  Bit Score: 110.33  E-value: 1.89e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513  96 HLTAVVTDLRSQRLgiRRTTRQVDRDDAADRRAAIADLVDDALRAAGRTRADVLALCVGVPAPVD-ESGRSPHHRHLFWD 174
Cdd:cd24073   12 RITAVLTDLRGNVL--ASHTLPLDSGDPEAVAEAIAEAVAELLAQAGLSPDRLLGIGVGLPGLVDaETGICRWSPLLGWR 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513 175 RMNpgLADVFRAWAPL-VRVDNDASLAAVAEGSVGAAVGCRSYIALLAGERLGSGVVIDGNLLRGAHGGVGEmvaFDH-- 251
Cdd:cd24073   90 DVP--LAELLEERLGLpVYVENDVNALALAEHWFGAGRGLDNFAVVTIGRGIGCGLVVDGRLYRGAHGGAGE---IGHtt 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513 252 VEGVGTA-----RG-LGTRAAEWALEAIERGdvtgplAAIPRDRLDGQAVIELASQGDPDAQRIVHRVGVVLARIVATLG 325
Cdd:cd24073  165 VDPDGPPcrcgkRGcLEAYASDPAILRQARE------AGLRGEPLTIEDLLAAARAGDPAARAILRRAGRALGLALANLV 238

                        250
                 ....*....|..
gi 938165513 326 SMFDPERVVVTG 337
Cdd:cd24073  239 NLLDPELIIISG 250
ROK pfam00480
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ...
 88-337 3.94e-20

ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif.


Pssm-ID: 395384 [Multi-domain]  Cd Length: 292  Bit Score: 89.71  E-value: 3.94e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513   88 VGVDAGHAHLTAVVTDLRSQRLGIRR--TTRQVDRDDAADRRAAiadLVDDALRAAGrtraDVLALCVGVPAPVDESGRS 165
Cdd:pfam00480   1 IGIDIGGTKIAAALFDEEGEILARERvpTPTTTTEETLVDAIAF---FVDSAQRKFG----ELIAVGIGSPGLISPKYGY 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513  166 PHH-RHLFWDrmNPGLADVFRAWAPL-VRVDNDASLAAVAEGSVGAAVGCRSYIALLAGERLGSGVVIDGNLLRGAHGGV 243
Cdd:pfam00480  74 ITNtPNIGWD--NFDLVEKLEERFNVpVFFENDANAAALAEAVFGASKDVQNVIYVTVGTGVGGGVISNGKLFTGRNGVA 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513  244 GEMvafDH--VEGVGTARGLGTRAaewALEAIERGDVTGPLAAIPRDRLDGQAVIELASQGDPDAQRIVHRVGVVLARIV 321
Cdd:pfam00480 152 GEI---GHiqLDPNGPKCGCGNHG---CLETIASGRALEKRYQQKGEDLEGKDIIVLAEQGDEVAEEAVERLARYLAKAI 225

                         250
                  ....*....|....*.
gi 938165513  322 ATLGSMFDPERVVVTG 337
Cdd:pfam00480 226 ANLINLFDPQAIVLGG 241
PRK09557 PRK09557
fructokinase; Reviewed
 191-337 1.97e-05

fructokinase; Reviewed


Pssm-ID: 236565 [Multi-domain]  Cd Length: 301  Bit Score: 46.17  E-value: 1.97e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513 191 VRVDNDASLAAVAEGSVGAAVGCRSYIALLAGERLGSGVVIDGNLLRGAHGGVGE--------MVAFDHVEGVGTARGLG 262
Cdd:PRK09557 100 VRLANDANCLAVSEAVDGAAAGKQTVFAVIIGTGCGAGVAINGRVHIGGNGIAGEwghnplpwMDEDELRYRNEVPCYCG 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513 263 TRAaewALEAIERGdvTGplaaIPRD--RLDGQA-----VIELASQGDPDAQRIVHRVGVVLARIVATLGSMFDPERVVV 335
Cdd:PRK09557 180 KQG---CIETFISG--TG----FATDyrRLSGKAlkgseIIRLVEEGDPVAELAFRRYEDRLAKSLAHVINILDPDVIVL 250


                 ..
gi 938165513 336 TG 337
Cdd:PRK09557 251 GG 252
 
Name Accession Description Interval E-value
NagC COG1940
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ...
 81-337 2.94e-34

Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];


Pssm-ID: 441543 [Multi-domain]  Cd Length: 306  Bit Score: 128.86  E-value: 2.94e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513  81 REDAGVLVGVDAGHAHLTAVVTDLRSQRLGiRRTTRQVDRDDAADRRAAIADLVDDALRAAGRTRADVLALCVGVPAPVD 160
Cdd:COG1940    1 NPDAGYVIGIDIGGTKIKAALVDLDGEVLA-RERIPTPAGAGPEAVLEAIAELIEELLAEAGISRGRILGIGIGVPGPVD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513 161 -ESGR---SPHHRHlfWDRMNpgLADVFRAWAPL-VRVDNDASLAAVAEGSVGAAVGCRSYIALLAGERLGSGVVIDGNL 235
Cdd:COG1940   80 pETGVvlnAPNLPG--WRGVP--LAELLEERLGLpVFVENDANAAALAEAWFGAGRGADNVVYLTLGTGIGGGIVINGKL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513 236 LRGAHGGVGEM----VAFD----------HVEGVGTARGLGTRAAEWaleaiergdvtgplaaIPRDRLDGQAVIELASQ 301
Cdd:COG1940  156 LRGANGNAGEIghmpVDPDgplcgcgnrgCLETYASGPALLRRAREL----------------GGAEKLTAEELFAAARA 219

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 938165513 302 GDPDAQRIVHRVGVVLARIVATLGSMFDPERVVVTG 337
Cdd:COG1940  220 GDPLALEVLDEAARYLGIGLANLINLLDPEVIVLGG 255
ASKHA_ATPase_ROK_CYANR cd24073
ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; ...
 96-337 1.89e-27

ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; CYANR acts as transcriptional repressor of cyclobis-(1-6)-alpha-nigerosyl (CNN) degrading enzymes. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466923 [Multi-domain]  Cd Length: 304  Bit Score: 110.33  E-value: 1.89e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513  96 HLTAVVTDLRSQRLgiRRTTRQVDRDDAADRRAAIADLVDDALRAAGRTRADVLALCVGVPAPVD-ESGRSPHHRHLFWD 174
Cdd:cd24073   12 RITAVLTDLRGNVL--ASHTLPLDSGDPEAVAEAIAEAVAELLAQAGLSPDRLLGIGVGLPGLVDaETGICRWSPLLGWR 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513 175 RMNpgLADVFRAWAPL-VRVDNDASLAAVAEGSVGAAVGCRSYIALLAGERLGSGVVIDGNLLRGAHGGVGEmvaFDH-- 251
Cdd:cd24073   90 DVP--LAELLEERLGLpVYVENDVNALALAEHWFGAGRGLDNFAVVTIGRGIGCGLVVDGRLYRGAHGGAGE---IGHtt 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513 252 VEGVGTA-----RG-LGTRAAEWALEAIERGdvtgplAAIPRDRLDGQAVIELASQGDPDAQRIVHRVGVVLARIVATLG 325
Cdd:cd24073  165 VDPDGPPcrcgkRGcLEAYASDPAILRQARE------AGLRGEPLTIEDLLAAARAGDPAARAILRRAGRALGLALANLV 238

                        250
                 ....*....|..
gi 938165513 326 SMFDPERVVVTG 337
Cdd:cd24073  239 NLLDPELIIISG 250
ASKHA_ATPase_ROK_BsXylR-like cd24076
ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This ...
 85-337 3.26e-25

ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Bacillus subtilis xylose repressor (BsXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. BsXylR acts as transcriptional repressor of xylose-utilizing enzymes.


Pssm-ID: 466926 [Multi-domain]  Cd Length: 303  Bit Score: 104.18  E-value: 3.26e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513  85 GVLVGVDAGHAHLTAVVTDLRSQRLGiRRTTRQVDRDDAADRRAAIADLVDDALRAAGRTRADVLALCVGVPAPVD-ESG 163
Cdd:cd24076    1 GAVIGVELGVDYITVVVTDLAGEVLW-RREVPLPASDDPDEVLAQLAALIREALAAAPDSPLGILGIGVGVPGLVDsEDG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513 164 RSPHHRHLFWDRMNpgLADVFRAWAPL-VRVDNDASLAAVAEGSVGAAVGCRSYIALLAGERLGSGVVIDGNLLRGAHGG 242
Cdd:cd24076   80 VVLLAPNLGWRDVP--LRDLLEEALGVpVFVDNEANAAALAEKRFGAGRGVSDLVYLSAGVGIGAGIILDGELYRGASGF 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513 243 VGEM----VAFDHVEGVGTARG-LGTRAAEWAL-EAIERGDVTGPLAAIPrdrldgqAVIELASQGDPDAQRIVHRVGVV 316
Cdd:cd24076  158 AGEIghmtVDPDGPPCSCGNRGcWETYASERALlRAAGRLGAGGEPLSLA-------ELVEAARAGDPAALAALEEVGEY 230

                        250       260
                 ....*....|....*....|.
gi 938165513 317 LARIVATLGSMFDPERVVVTG 337
Cdd:cd24076  231 LGIGLANLVNTFNPELVVLGG 251
ASKHA_NBD_ROK_TM1224-like cd24059
nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and ...
 133-337 5.65e-22

nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to N-acetylglucosamine kinase (Tm1224; EC 2.7.1.59) from Thermotoga maritima, which belongs to kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Tm1224 lacks the cysteine-rich zinc-binding motif, which presents in other family members.


Pssm-ID: 466909 [Multi-domain]  Cd Length: 305  Bit Score: 94.96  E-value: 5.65e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513 133 LVDDALRAAGRTRaDVLALCVGVPAPVD-ESGR--SPHHrhlFWDRMNPGLADVFR------AWaplvrVDNDASLAAVA 203
Cdd:cd24059   48 LIDRLLEKENIKS-KILGIGIGAPGPLDvEKGIilNPPN---FPGWENIPLVELLEekfgipVY-----LDNDANAAALA 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513 204 EGSVGAAVGCRSYIALLAGERLGSGVVIDGNLLRGAHGGVGEM----VAFDHVEGVGTARG-LGTRAAEWALEAIERgdv 278
Cdd:cd24059  119 EKWYGKGKNYDNFIYILADEGIGAGIIINGKLYRGVDGYAGEIghtsIDINGPRCSCGNRGcLELYASIPAIEKKAR--- 195

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 938165513 279 tgplAAIPRDRLDGQAVIELASQGDPDAQRIVHRVGVVLARIVATLGSMFDPERVVVTG 337
Cdd:cd24059  196 ----SALGSGRSFQLDIVEALQKGDPIADEVIEEAAKYLGIGLVNLINLLNPEAIIIGG 250
ROK pfam00480
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ...
 88-337 3.94e-20

ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif.


Pssm-ID: 395384 [Multi-domain]  Cd Length: 292  Bit Score: 89.71  E-value: 3.94e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513   88 VGVDAGHAHLTAVVTDLRSQRLGIRR--TTRQVDRDDAADRRAAiadLVDDALRAAGrtraDVLALCVGVPAPVDESGRS 165
Cdd:pfam00480   1 IGIDIGGTKIAAALFDEEGEILARERvpTPTTTTEETLVDAIAF---FVDSAQRKFG----ELIAVGIGSPGLISPKYGY 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513  166 PHH-RHLFWDrmNPGLADVFRAWAPL-VRVDNDASLAAVAEGSVGAAVGCRSYIALLAGERLGSGVVIDGNLLRGAHGGV 243
Cdd:pfam00480  74 ITNtPNIGWD--NFDLVEKLEERFNVpVFFENDANAAALAEAVFGASKDVQNVIYVTVGTGVGGGVISNGKLFTGRNGVA 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513  244 GEMvafDH--VEGVGTARGLGTRAaewALEAIERGDVTGPLAAIPRDRLDGQAVIELASQGDPDAQRIVHRVGVVLARIV 321
Cdd:pfam00480 152 GEI---GHiqLDPNGPKCGCGNHG---CLETIASGRALEKRYQQKGEDLEGKDIIVLAEQGDEVAEEAVERLARYLAKAI 225

                         250
                  ....*....|....*.
gi 938165513  322 ATLGSMFDPERVVVTG 337
Cdd:pfam00480 226 ANLINLFDPQAIVLGG 241
ASKHA_ATPase_ROK cd23763
ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family ...
 88-252 6.39e-20

ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family corresponds to a group of proteins including sugar kinases, transcriptional repressors, and yet uncharacterized open reading frames. ROK family sugar kinases phosphorylate a range of structurally distinct hexoses including the key carbon source D-glucose, various glucose epimers, and several acetylated hexosamines. The sugar kinases include N-acetyl-D-glucosamine kinase (NAGK; EC 2.7.1.59), polyphosphate glucokinase (PPGK; EC 2.7.1.63/EC 2.7.1.2), glucokinase (GLK; EC 2.7.1.2), fructokinase (FRK; EC 2.7.1.4), hexokinase (HK; EC 2.7.1.1), D-allose kinase (AlsK; EC 2.7.1.55), bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE; EC 3.2.1.183/EC 2.7.1.60), N-acetylmannosamine kinase (NanK; EC 2.7.1.60), beta-glucoside kinase (BglK; EC 2.7.1.85), and N-acetylglucosamine kinase (EC 2.7.1.59). The family also contains the repressor proteins, such as N-acetylglucosamine repressor (NagC), xylose repressor (XylR), cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and protein Mlc. ROK kinases harbor a conserved N-terminal ATP binding motif of sequence DxGxT, while ROK repressors possess a N-terminal extension that contains a canonical helix-turn-helix DNA binding motif. The ROK family proteins belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466849 [Multi-domain]  Cd Length: 239  Bit Score: 87.90  E-value: 6.39e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513  88 VGVDAGHAHLTAVVTDLRSQRLGiRRTTRQVDRDDAADRRAAIADLVDDALRAAGrTRADVLALCVGVPAPVD-ESGRSP 166
Cdd:cd23763    1 IGIDIGGTKIRAALVDLDGEILA-RERVPTPAEEGPEAVLDRIAELIEELLAEAG-VRERILGIGIGVPGPVDpETGIVL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513 167 HHRHLFWDRMNPgLADVFRAWAPL-VRVDNDASLAAVAEGSVGAAVGCRSYIALLAGERLGSGVVIDGNLLRGAHGGVGE 245
Cdd:cd23763   79 FAPNLPWWKNVP-LRELLEERLGLpVVVENDANAAALGEAWFGAGRGVRNFVYITLGTGIGGGIIIDGKLYRGANGAAGE 157

                        170
                 ....*....|
gi 938165513 246 ---MVAFDHV 252
Cdd:cd23763  158 ighITVLEEA 167
ASKHA_NBD_ROK_FnNanK-like cd24068
nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and ...
 191-337 5.57e-19

nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and similar proteins; The family includes Fusobacterium nucleatum N-acetylmannosamine kinase (NanK; EC 2.7.1.60) and beta-glucoside kinase (BglK; EC 2.7.1.85) from Klebsiella pneumoniae and Listeria innocua. NanK catalyzes the second step of the sialic acid catabolic pathway, transferring a phosphate group from adenosine 5'-triphosphate to the C6 position of N-acetylmannosamine to generate N-acetylmannosamine 6-phosphate. Unlike other NanK enzymes and ROK family members, F. nucleatum NanK does not have a conserved zinc-binding site. BglK catalyzes the ATP-dependent phosphorylation of cellobiose to produce cellobiose-6'-P. It may have a dual role of kinase and transcriptional regulator of the cellobiose-PTS operon. The subfamily belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466918 [Multi-domain]  Cd Length: 294  Bit Score: 86.46  E-value: 5.57e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513 191 VRVDNDASLAAVAEGSVGAAVGCRSYIALLAGERLGSGVVIDGNLLRGAHGGVGEM----VAFDHVEGVGTARGLGTRAA 266
Cdd:cd24068  102 VAVENDVNCAALAEKWLGAAKGLDDFLCLTLGTGIGGAIILDGRLYRGANGSAGELghmvVDPGGRPCCCGGKGCLEQYA 181

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 938165513 267 ewALEAIERgDVTgplAAIPRDRLDGQAVIELASQGDPDAQRIVHRVGVVLARIVATLGSMFDPERVVVTG 337
Cdd:cd24068  182 --SGTALVR-RVA---EALGEPGIDGREIFDLADAGDPLAKEVVEEFAEDLATGLANLVHIFDPEVIVIGG 246
ASKHA_NBD_ROK-like cd24152
nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This ...
 191-337 5.07e-16

nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This subfamily is composed of uncharacterized proteins belonging to the the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466988 [Multi-domain]  Cd Length: 286  Bit Score: 77.61  E-value: 5.07e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513 191 VRVDNDASLAAVAEGSVGAAVGCRSYIALLAGERLGSGVVIDGNLLRGAHGGVGEM----VAFDHVEGVGTARGLGTRAA 266
Cdd:cd24152   98 VSIENDAKCAALAELWLGSLKGIKNGAVIVLGTGIGGAIIIDGKLYRGSHFFAGEFsyllTDDDDKDLLFFSGLASMFGL 177

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 938165513 267 ewaleaiergdVTGPLAAIPRDRLDGQAVIELASQGDPDAQRIVHRVGVVLARIVATLGSMFDPERVVVTG 337
Cdd:cd24152  178 -----------VKRYNKAKGLEPLDGEEIFEKYAKGDEAAKKILDEYIRNLAKLIYNIQYILDPEVIVIGG 237
ASKHA_NBD_ROK_SgGLK-like cd24061
nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; ...
 143-337 1.18e-15

nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466911 [Multi-domain]  Cd Length: 306  Bit Score: 77.01  E-value: 1.18e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513 143 RTRADVLALCVGVPAPVDESGRSPHHR-HLFWDrmNPGLADVFRAWAPL-VRVDNDASLAAVAEGSVGAAVGCRSYIALL 220
Cdd:cd24061   49 REGHDVSAVGVAAAGFVDADRATVLFApNIAWR--NEPLKDLLEARIGLpVVIENDANAAAWAEYRFGAGRGTDDMVMIT 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513 221 AGERLGSGVVIDGNLLRGAHGGVGEmvaFDHVEGV--GTARGLGTR------AAEWAL--EAIERGDVTG-----PLAAI 285
Cdd:cd24061  127 VGTGLGGGIVIGGKLLRGAFGIAGE---FGHIRVVpdGLLCGCGSRgcweqyASGRALvrYAKEAANATPegaavLLADG 203

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 938165513 286 PRDRLDGQAVIELASQGDPDAQRIVHRVGVVLARIVATLGSMFDPERVVVTG 337
Cdd:cd24061  204 SVDGITGKHISEAARAGDPVALDALRELARWLGAGLASLAALLDPELFVIGG 255
ASKHA_NBD_ROK_ApGLK-like cd24063
nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; ...
 86-337 1.87e-15

nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466913 [Multi-domain]  Cd Length: 308  Bit Score: 76.22  E-value: 1.87e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513  86 VLVGVDAGHAHLTAVVTDLRSQRLGIRRTtRQVDRDDAADRRAAIADLVDDALRAAGRtrADVLALCVGVPAPVD-ESGR 164
Cdd:cd24063    1 YYVAVDIGGTWIRAGLVDEDGRILLKIRQ-PTPKTGDPGTVSEQVLGLIETLLSKAGK--DSIEGIGVSSAGPLDlRKGT 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513 165 SPHHRHLFWDRMnPGLADVFRAWAPLVRVDNDASLAAVAEGSVGAAVGCRS--YIALLAGerLGSGVVIDGNLLRGAHGG 242
Cdd:cd24063   78 IVNSPNIKGKEI-PLVEPLKEEFNIPVALLNDAVAAALGEHLFGAGRGTSNlvYITISTG--IGGGVIVDGRLLLGKNGN 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513 243 ---VGEMV------------AFDHVEGVGTARGLGTRAAEWAleaiERGDVTGPLAAIPRD--RLDGQAVIELASQGDPD 305
Cdd:cd24063  155 aaeVGHLVvdtesglkcgcgGYGHWEAFASGRGIPRFAREWA----EGFSSRTSLKLRNPGgeGITAKEVFSAARKGDPL 230

                        250       260       270
                 ....*....|....*....|....*....|..
gi 938165513 306 AQRIVHRVGVVLARIVATLGSMFDPERVVVTG 337
Cdd:cd24063  231 ALKIIEKLARYNGRGIANVINAYDPELIVIGG 262
ASKHA_NBD_ROK_BsGLK-like cd24062
nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; ...
 134-337 4.35e-15

nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466912 [Multi-domain]  Cd Length: 311  Bit Score: 75.40  E-value: 4.35e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513 134 VDDALRAAGRTRADVLALCVGVPAPVD-ESGRSPHHRHLFWDrmNPGLADVF-RAWAPLVRVDNDASLAAVAEGSVGAAV 211
Cdd:cd24062   48 IQQLLEELGYSKEDLIGIGVGVPGPVDvETGTVEVAVNLGWK--NFPLKDKLeALTGIPVVIDNDANAAALGEMWKGAGQ 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513 212 GCRSYIALLAGERLGSGVVIDGNLLRGAHGGVGEM----VAFDH-----------VEGVGTARGLgtraAEWALEAIERG 276
Cdd:cd24062  126 GAKDLVFITLGTGVGGGVIANGKIVHGANGAAGEIghitVNPEGgapcncgktgcLETVASATGI----VRIAREELEEG 201

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 938165513 277 DvtGPLAAIPRDR---LDGQAVIELASQGDPDAQRIVHRVGVVLARIVATLGSMFDPERVVVTG 337
Cdd:cd24062  202 K--GSSALRILALggeLTAKDVFEAAKAGDELALAVVDTVARYLGLALANLANTLNPEKIVIGG 263
ASKHA_NBD_ROK_TtHK-like cd24065
nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; ...
 87-337 1.23e-14

nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; HK (EC 2.7.1.1) possesses the ability to transfer an inorganic phosphate group from ATP to a substrate. It catalyzes the ATP-dependent phosphorylation of aldo- and keto-hexose sugars to the hexose-6-phosphate (H6P). Thermus thermophilus HK possesses significant enzymatic activity against glucose and mannose. However, it shows little catalytic capacity for galactose and fructose. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466915 [Multi-domain]  Cd Length: 289  Bit Score: 73.90  E-value: 1.23e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513  87 LVGVDAGHAHLTAVVtdLRSQRLgIRRTTRQVDRDDAADRRAAIADLVDDALRAAGRtradVLALCVGVPAPVD-ESGRS 165
Cdd:cd24065    2 TIGLDLGGTKIAAGV--VDGGRI-LSRLVVPTPREGGEAVLDALARAVEALQAEAPG----VEAVGLGVPGPLDfRRGRV 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513 166 PHHRHLfwdrmnPGLADV------FRAWAPLVRVDNDASLAAVAEGSVGAAVGCRSYIALLAGERLGSGVVIDGNLLRGA 239
Cdd:cd24065   75 RFAPNI------PGLTDFpirrglAERLGLPVVLENDANAAALAEHHYGAARGTESSVYVTISTGIGGGLVLGGRVLRGR 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513 240 HGGVGEmVAFDHVEGVGTARGLGTraaEWALEAIERGdvtgplAAIPRDR-------LDGQAVIELASQGDPDAQRIVHR 312
Cdd:cd24065  149 HGQAGE-IGHTTVLPGGPMCGCGL---VGCLEALASG------RALARDAsfaygrpMSTAELFELAQQGEPKALRIVEQ 218

                        250       260
                 ....*....|....*....|....*
gi 938165513 313 VGVVLARIVATLGSMFDPERVVVTG 337
Cdd:cd24065  219 AAAHLGIGLANLQKALDPEVFVLGG 243
ASKHA_ATPase_ROK_YphH-like cd24072
ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily ...
 134-337 2.18e-14

ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Escherichia coli protein YphH that belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466922 [Multi-domain]  Cd Length: 308  Bit Score: 73.22  E-value: 2.18e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513 134 VDDALRaagRTRADVLALCVGVPAPVD-ESGRSPHHRHLFWDRMNpgLADVFRA-WAPLVRVDNDASLAAVAEGSVGAAV 211
Cdd:cd24072   49 IDRLLK---LWKDRVKGIALAIQGLVDsHKGVSLWSPGAPWRNIE--IKYLLEErYGIPVFVENDCNMLALAEKWQGELR 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513 212 GCRSYIALLAGERLGSGVVIDGNLLRGAHGGVGE---MVAFD--HVEGVGtARG-LGTRAAEWALEAIERG-DVTGPLAA 284
Cdd:cd24072  124 QSRDFCVINLDYGIGSAIVIDNKLYIGASSGSGEighTKVNPdgARCDCG-RRGcLETVASNSALKRNARVtLKLGPVSA 202

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 938165513 285 IPRDrLDGQAVIELASQGDPDAQRIVHRVGVVLARIVATLGSMFDPERVVVTG 337
Cdd:cd24072  203 DPEK-LTMEQLIEALEEGEPIATQIFDRAANAIGRSLANILNLLNPEQVLLYG 254
ASKHA_NBD_ROK_TmGLK-like cd24064
nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; ...
 147-337 4.12e-12

nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466914 [Multi-domain]  Cd Length: 301  Bit Score: 66.37  E-value: 4.12e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513 147 DVLALCVGVPAPVD-ESG---RSPHhrhlFWDRMNPGLADVFRAWAPL-VRVDNDASLAAVAEGSVGAAVGCRSYIALLA 221
Cdd:cd24064   55 ELLGIGIGSPGSIDrENGivrFSPN----FPDWRNFPLVPLIEERTGIkVFLENDANAFALGEWWFGNAKGSNHIIGLTL 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513 222 GERLGSGVVIDGNLLRGAHG---GVGEMVAFDH-----------VEGVGTARGLGTRAAEWaleaieRGDVTGPLAAIPr 287
Cdd:cd24064  131 GTGVGSGVICHGQLLTGYDGiaaELGHVIVEPNgpicgcgnrgcVEAFASATAIIRYARES------RKRYPDSLAGES- 203

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 938165513 288 DRLDGQAVIELASQGDPDAQRIVHRVGVVLARIVATLGSMFDPERVVVTG 337
Cdd:cd24064  204 EKINAKHVFDAARKNDPLATMVFRRVVDALAIAIGGFVHIFNPEIIIIGG 253
ASKHA_ATPase_ROK_NagC cd24075
ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as ...
 88-337 5.79e-12

ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as a repressor of the nagEBACD operon involved in the uptake and degradation of the amino sugars, N-acetyl-D-glucosamine (GlcNAc) and glucosamine (GlcN). It acts both as an activator and a repressor for the transcription of the glmSU operon, encoding proteins necessary for the synthesis of GlcN (glmS) and the formation of UDP-GlcNAc (glmU). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466925 [Multi-domain]  Cd Length: 315  Bit Score: 66.24  E-value: 5.79e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513  88 VGVDAGHAHLTAVVTDLRSQRLGIR------RTTRQVDRDDAAdrraaiadLVDDALRAAGRTRADVLALCVGVPAPVD- 160
Cdd:cd24075    4 LAVRLGRHDLTLGLYDLSGELLAEHtvpltaLNQEALLSQLIE--------EIAQFLKSHRRKTQRLIAISITLPGLINp 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513 161 ESGRSPHHRHLFWDRMnpGLADVFRAWAPL-VRVDNDASLAAVAEGSVGAAVGCRSYIALLAGERLGSGVVIDGNLLRGA 239
Cdd:cd24075   76 KTGVVHYMPHIQVKSW--PIVEELEQRFNVpCFIGNDIRSLALAEHYFGASKDCKDSILVRIHHGIGAGIIIDGKLFLGQ 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513 240 HGGVGEmVAFDHVEGVGTARGLG------TRAAEWALE-----AIERGDVTGplaaIPRDRLDGQAVIELASQGDPDAQR 308
Cdd:cd24075  154 NGNAGE-IGHIQIEPLGERCHCGnfgcleTVASNAAIEqrvkkLLKQGYASQ----LTLQDCTIKDICQAALNGDQLAQD 228

                        250       260
                 ....*....|....*....|....*....
gi 938165513 309 IVHRVGVVLARIVATLGSMFDPERVVVTG 337
Cdd:cd24075  229 VIKRAGRYLGKVIAILINLLNPQKIIIAG 257
ASKHA_ATPase_ROK_Lmo0178-like cd24071
ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily ...
 191-337 2.12e-10

ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Listeria monocytogenes Lmo0178 protein, which is a predicted transcription repressor belonging to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466921 [Multi-domain]  Cd Length: 312  Bit Score: 61.15  E-value: 2.12e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513 191 VRVDNDASLAAVAEGSVGAAVGCRSYIALLAGERLGSGVVIDGNLLRGAHGGVGEmvaFDHV----EG----VGTARGLG 262
Cdd:cd24071  105 VFIDNDVNSFALAELWKGKGKGYSNFICVTVGAGIGSSLVIDGKLYTGNFGGAGE---IGHMtiqpDGrkcyCGQKGCLE 181

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 938165513 263 TRAAEWAL-EAIERGDVTGPLAAIPR-DRLDGQAVIELASQGDPDAQRIVHRVGVVLARIVATLGSMFDPERVVVTG 337
Cdd:cd24071  182 AYASFEALvNEIKELTESYPLSLLKElEDFEIEKVREAAEEGDSVATELFKKAGEYLGIGIKNLINIFNPEAIIIGG 258
ASKHA_NBD_ROK_GNE cd24060
nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase ...
 191-337 4.21e-09

nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) and similar proteins; GNE (EC 3.2.1.183/EC 2.7.1.60), also called UDP-GlcNAc-2-epimerase/ManAc kinase, is a bi-functional enzyme that plays a key role in sialic acid biosynthesis. It regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It plays an essential role in early development and required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. GNE is the only human protein that contains a kinase domain belonging to the ROK (repressor, ORF, kinase) family. Mutations of the GNE protein cause sialurea or autosomal recessive inclusion body myopathy/Nonaka myopathy.


Pssm-ID: 466910 [Multi-domain]  Cd Length: 305  Bit Score: 57.43  E-value: 4.21e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513 191 VRVDNDASLAAVAEGSVGAAVGCRSYIALLAGERLGSGVVIDGNLLRGAHGGVGE----MVAFDHVEGVGTARGL----- 261
Cdd:cd24060  105 VWVDNDGNCAALAERKFGHGKGVENFVTVITGTGIGGGIILNHELIHGSSFCAAElghiVVSLDGPDCMCGSHGCveaya 184

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 938165513 262 -GTRAAEWALEAIERGDVTGPLAAIPRDR-LDGQAVIELASQGDPDAQRIVHRVGVVLARIVATLGSMFDPERVVVTG 337
Cdd:cd24060  185 sGMALQREAKKLHDEDLLLVEGMSVTNDEeVTAKHLIQAAKLGNAKAQKILRTAGTALGLGIVNILHTLNPSLVILSG 262
ASKHA_NBD_ROK_EcNanK-like cd24069
nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar ...
 191-337 3.53e-08

nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar proteins; N-acetylmannosamine kinase (NanK; EC 2.7.1.60), also called ManNAc kinase, or N-acetyl-D-mannosamine kinase, catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P. It has also low level glucokinase activity in vitro. This subfamily also contains Brucella melitensis bifunctional enzyme NanE/NanK (EC 5.1.3.9/EC 2.7.1.60), which also converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466919 [Multi-domain]  Cd Length: 283  Bit Score: 54.21  E-value: 3.53e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513 191 VRVDNDASLAAVAEGSVGAAVGCRSYIALLAGERLGSGVVIDGNLLRGAHGGVGEmVAFDHVEGVGTARGLGTRAAewaL 270
Cdd:cd24069   96 VVLLNDAQAAAWGEYQAGDGEGVGNLVFITVSTGVGGGLVLNGQLLTGPNGLAGH-IGHTLADPPGPVCGCGRRGC---V 171

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 938165513 271 EAIERGDVTGPLAA-IPRDRLDGQAVIELASQGDPDAQRIVHRVGVVLARIVATLGSMFDPERVVVTG 337
Cdd:cd24069  172 EAIASGTAIAAAASeILGEPVDAKDVFERARSGDEEAARLIDRAARALADLIADLKATLDLDCVVIGG 239
ASKHA_NBD_ROK_NAGK cd24057
nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; ...
 191-337 1.96e-07

nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; NAGK (EC 2.7.1.59), also called GlcNAc kinase, catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466907 [Multi-domain]  Cd Length: 298  Bit Score: 52.23  E-value: 1.96e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513 191 VRVDNDASLAAVAEGSVGAAVGCRSYIALLAGERLGSGVVIDGNLLRGAHGGVGEmvaFDHVEGVGTARGLGTRAAEWA- 269
Cdd:cd24057  100 VRIDNDANCFALSEAWDGAGRGYPSVFGLILGTGVGGGLVVNGRLVGGRSGIAGE---WGHGPLPADALLLGYDLPVLRc 176

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 938165513 270 -------LEAIERGDVTGPLAA-IPRDRLDGQAVIELASQGDPDAQRIVHRVGVVLARIVATLGSMFDPERVVVTG 337
Cdd:cd24057  177 gcgqtgcLETYLSGRGLERLYAhLYGEELDAPEIIAAWAAGDPQAVAHVDRWLDLLAGCLANILTALDPDVVVLGG 252
ASKHA_NBD_ROK_EcFRK-like cd24066
nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; ...
 191-337 4.16e-07

nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; Escherichia coli FRK (EC 2.7.1.4), also called D-fructose kinase, manno(fructo)kinase, or MAK, catalyzes the phosphorylation of fructose to fructose-6-phosphate. It has also low level glucokinase activity in vitro. It is not able to phosphorylate D-ribose, D-mannitol, D-sorbitol, inositol, and L-threonine. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466916 [Multi-domain]  Cd Length: 294  Bit Score: 51.05  E-value: 4.16e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513 191 VRVDNDASLAAVAEGSVGAAVGCRSYIALLAGERLGSGVVIDGNLLRGAHGGVGE-----MVAFDHVEGVGTARGLGTRA 265
Cdd:cd24066   99 VRIENDANCFALSEATDGAGAGAGVVFGVILGTGVGGGIVVNGRVLTGANGIAGEwghnpLPWPDEDELPGPPCYCGKRG 178

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 938165513 266 AewaleaIERGdVTGPlaAIPRD-------RLDGQAVIELASQGDPDAQRIVHRVGVVLARIVATLGSMFDPERVVVTG 337
Cdd:cd24066  179 C------VETF-LSGP--ALERDyarltgkTLSAEEIVALARAGDAAAVATLDRFLDRLGRALANVINILDPDVIVLGG 248
PRK09557 PRK09557
fructokinase; Reviewed
 191-337 1.97e-05

fructokinase; Reviewed


Pssm-ID: 236565 [Multi-domain]  Cd Length: 301  Bit Score: 46.17  E-value: 1.97e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513 191 VRVDNDASLAAVAEGSVGAAVGCRSYIALLAGERLGSGVVIDGNLLRGAHGGVGE--------MVAFDHVEGVGTARGLG 262
Cdd:PRK09557 100 VRLANDANCLAVSEAVDGAAAGKQTVFAVIIGTGCGAGVAINGRVHIGGNGIAGEwghnplpwMDEDELRYRNEVPCYCG 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513 263 TRAaewALEAIERGdvTGplaaIPRD--RLDGQA-----VIELASQGDPDAQRIVHRVGVVLARIVATLGSMFDPERVVV 335
Cdd:PRK09557 180 KQG---CIETFISG--TG----FATDyrRLSGKAlkgseIIRLVEEGDPVAELAFRRYEDRLAKSLAHVINILDPDVIVL 250


                 ..
gi 938165513 336 TG 337
Cdd:PRK09557 251 GG 252
PRK05082 PRK05082
N-acetylmannosamine kinase; Provisional
 195-337 3.33e-05

N-acetylmannosamine kinase; Provisional


Pssm-ID: 235338 [Multi-domain]  Cd Length: 291  Bit Score: 45.29  E-value: 3.33e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513 195 NDASLAAVAE-GSVGAAVGCRSYIALLAGerLGSGVVIDGNLLRGAH---GGVGEMVAFDHvegvGTARGLGTRAAewaL 270
Cdd:PRK05082 104 NDAQAAAWAEyQALPDDIRNMVFITVSTG--VGGGIVLNGKLLTGPGglaGHIGHTLADPH----GPVCGCGRRGC---V 174

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 938165513 271 EAIERGDVTGPLAAIPRDRLDGQAVIELASQGDPDAQRIVHRVGVVLARIVATLGSMFDPERVVVTG 337
Cdd:PRK05082 175 EAIASGRAIAAAAQGWLAGCDAKTIFERAGQGDEQAQALINRSAQAIARLIADLKATLDCQCVVLGG 241
ASKHA_NBD_ROK_AlsK cd24070
nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1. ...
 133-337 1.29e-03

nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1.55), also called allokinase, catalyzes the phosphorylation of D-allose to D-allose 6-phosphate. It has also low level glucokinase activity in vitro. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466920 [Multi-domain]  Cd Length: 293  Bit Score: 40.23  E-value: 1.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513 133 LVDDALRaagRTRADVLALCVGVPAPVDESGR----SPHHRHLfwDRMNpgLADVF-RAWAPLVRVDNDASLA------A 201
Cdd:cd24070   48 LIREYIE---EAGLKPAAIVIGVPGTVDKDRRtvisTPNIPGL--DGVN--LADILeNKLGIPVILERDVNLLllydmrA 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 938165513 202 VAEGSVGAAVGCrsYIallaGERLGSGVVIDGNLLRGAHGGVGEM--VAFDHVEGVGTARGLG---TRAAEWALEAI-ER 275
Cdd:cd24070  121 GNLDDEGVVLGF--YI----GTGIGNAILINGKPLRGKNGVAGELghIPVYGNGKPCGCGNTGcleTYASGRALEEIaEE 194

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 938165513 276 GDVTGPLAAIPRDRLDgqavielasqgDPDAQRIVHRvgvvLARIVATLGSMFDPERVVVTG 337
Cdd:cd24070  195 HYPDTPILDIFVDHGD-----------EPELDEFVED----LALAIATEINILDPDAVILGG 241
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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