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Conserved domains on  [gi|937829661|gb|ALI99518|]
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methionine aminopeptidase [Rufibacter tibetensis]

Protein Classification

type I methionyl aminopeptidase( domain architecture ID 10000257)

type I methionyl aminopeptidase (M24A family metallopeptidase) catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides

CATH:  3.90.230.10
EC:  3.4.11.18
Gene Ontology:  GO:0070006|GO:0046914|GO:0006508|GO:0004239
MEROPS:  M24
PubMed:  7674922

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Map COG0024
Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];
2-251 7.14e-150

Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];


:

Pssm-ID: 439795 [Multi-domain]  Cd Length: 250  Bit Score: 417.87  E-value: 7.14e-150
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661   2 IIYKTEEEIELIKQSANILSQVHGEIAKHVSEGVTTLKLDSIAEEFISDHGGSPSFKGYNGFKHSLCISLNSAVVHGIPS 81
Cdd:COG0024    1 IEIKTPEEIEKMREAGRIVAEVLDELAEAVKPGVTTLELDRIAEEFIRDHGAIPAFLGYYGFPKSICTSVNEVVVHGIPS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661  82 KYALQSGDVVSIDCGVFFKGFHSDSAYTHPVGDVPQEVTDLLTRTKESLYKGIEWAVAGARIGDVGHSIQTHVEQYGYGV 161
Cdd:COG0024   81 DRVLKDGDIVNIDVGAILDGYHGDSARTFVVGEVSPEARRLVEVTEEALYAGIAAAKPGNRLGDIGHAIQSYAESNGYSV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661 162 VRELVGHGLGRSLHESPEVPNYGKRGQGLKLQDGLVLAIEPMVNLGTRHVVQENDGWTIRTRDKKPSAHFEHTVVVRKGK 241
Cdd:COG0024  161 VREFVGHGIGREMHEEPQVPNYGRPGRGPRLKPGMVLAIEPMINAGTPEVKVLDDGWTVVTKDGSLSAQFEHTVAVTEDG 240

                        250
                 ....*....|
gi 937829661 242 AEILTTFDYI 251
Cdd:COG0024  241 PEILTLPDGG 250
 
Name Accession Description Interval E-value
Map COG0024
Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];
2-251 7.14e-150

Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 439795 [Multi-domain]  Cd Length: 250  Bit Score: 417.87  E-value: 7.14e-150
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661   2 IIYKTEEEIELIKQSANILSQVHGEIAKHVSEGVTTLKLDSIAEEFISDHGGSPSFKGYNGFKHSLCISLNSAVVHGIPS 81
Cdd:COG0024    1 IEIKTPEEIEKMREAGRIVAEVLDELAEAVKPGVTTLELDRIAEEFIRDHGAIPAFLGYYGFPKSICTSVNEVVVHGIPS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661  82 KYALQSGDVVSIDCGVFFKGFHSDSAYTHPVGDVPQEVTDLLTRTKESLYKGIEWAVAGARIGDVGHSIQTHVEQYGYGV 161
Cdd:COG0024   81 DRVLKDGDIVNIDVGAILDGYHGDSARTFVVGEVSPEARRLVEVTEEALYAGIAAAKPGNRLGDIGHAIQSYAESNGYSV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661 162 VRELVGHGLGRSLHESPEVPNYGKRGQGLKLQDGLVLAIEPMVNLGTRHVVQENDGWTIRTRDKKPSAHFEHTVVVRKGK 241
Cdd:COG0024  161 VREFVGHGIGREMHEEPQVPNYGRPGRGPRLKPGMVLAIEPMINAGTPEVKVLDDGWTVVTKDGSLSAQFEHTVAVTEDG 240

                        250
                 ....*....|
gi 937829661 242 AEILTTFDYI 251
Cdd:COG0024  241 PEILTLPDGG 250
PRK05716 PRK05716
methionine aminopeptidase; Validated
 1-246 4.09e-125

methionine aminopeptidase; Validated


Pssm-ID: 235576 [Multi-domain]  Cd Length: 252  Bit Score: 355.60  E-value: 4.09e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661   1 MIIYKTEEEIELIKQSANILSQVHGEIAKHVSEGVTTLKLDSIAEEFISDHGGSPSFKGYNGFKHSLCISLNSAVVHGIP 80
Cdd:PRK05716   2 AITIKTPEEIEKMRVAGRLAAEVLDEIEPHVKPGVTTKELDRIAEEYIRDQGAIPAPLGYHGFPKSICTSVNEVVCHGIP 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661  81 SKYALQSGDVVSIDCGVFFKGFHSDSAYTHPVGDVPQEVTDLLTRTKESLYKGIEWAVAGARIGDVGHSIQTHVEQYGYG 160
Cdd:PRK05716  82 SDKVLKEGDIVNIDVTVIKDGYHGDTSRTFGVGEISPEDKRLCEVTKEALYLGIAAVKPGARLGDIGHAIQKYAEAEGFS 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661 161 VVRELVGHGLGRSLHESPEVPNYGKRGQGLKLQDGLVLAIEPMVNLGTRHVVQENDGWTIRTRDKKPSAHFEHTVVVRKG 240
Cdd:PRK05716 162 VVREYCGHGIGRKFHEEPQIPHYGAPGDGPVLKEGMVFTIEPMINAGKREVKTLKDGWTVVTKDGSLSAQYEHTVAVTED 241


                 ....*.
gi 937829661 241 KAEILT 246
Cdd:PRK05716 242 GPEILT 247
MetAP1 cd01086
Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 10-246 4.53e-123

Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238519 [Multi-domain]  Cd Length: 238  Bit Score: 349.87  E-value: 4.53e-123
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661  10 IELIKQSANILSQVHGEIAKHVSEGVTTLKLDSIAEEFISDHGGSPSFKGYNGFKHSLCISLNSAVVHGIPSKYALQSGD 89
Cdd:cd01086    1 IEGMREAGRIVAEVLDELAKAIKPGVTTKELDQIAHEFIEEHGAYPAPLGYYGFPKSICTSVNEVVCHGIPDDRVLKDGD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661  90 VVSIDCGVFFKGFHSDSAYTHPVGDVPQEVTDLLTRTKESLYKGIEWAVAGARIGDVGHSIQTHVEQYGYGVVRELVGHG 169
Cdd:cd01086   81 IVNIDVGVELDGYHGDSARTFIVGEVSEEAKKLVEVTEEALYKGIEAVKPGNRIGDIGHAIEKYAEKNGYSVVREFGGHG 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 937829661 170 LGRSLHESPEVPNYGKRGQGLKLQDGLVLAIEPMVNLGTRHVVQENDGWTIRTRDKKPSAHFEHTVVVRKGKAEILT 246
Cdd:cd01086  161 IGRKFHEEPQIPNYGRPGTGPKLKPGMVFTIEPMINLGTYEVVTLPDGWTVVTKDGSLSAQFEHTVLITEDGPEILT 237
met_pdase_I TIGR00500
methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. ...
 2-246 2.23e-102

methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. Bacterial and organellar examples (type I) differ from eukaroytic and archaeal (type II) examples in lacking a region of approximately 60 amino acids between the 4th and 5th cobalt-binding ligands. This model describes type I. The role of this protein in general is to produce the mature form of cytosolic proteins by removing the N-terminal methionine. [Protein fate, Protein modification and repair]


Pssm-ID: 129591 [Multi-domain]  Cd Length: 247  Bit Score: 297.72  E-value: 2.23e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661    2 IIYKTEEEIELIKQSANILSQVHGEIAKHVSEGVTTLKLDSIAEEFISDHGGSPSFKGYNGFKHSLCISLNSAVVHGIPS 81
Cdd:TIGR00500   1 ISLKSPDEIEKIRKAGRLAAEVLEELEREVKPGVSTKELDRIAKDFIEKHGAKPAFLGYYGFPGSVCISVNEVVIHGIPD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661   82 KYALQSGDVVSIDCGVFFKGFHSDSAYTHPVGDVPQEVTDLLTRTKESLYKGIEWAVAGARIGDVGHSIQTHVEQYGYGV 161
Cdd:TIGR00500  81 KKVLKDGDIVNIDVGVIYDGYHGDTAKTFLVGKISPEAEKLLECTEESLYKAIEEAKPGNRIGEIGAAIQKYAEAKGFSV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661  162 VRELVGHGLGRSLHESPEVPNYGKRGQGLKLQDGLVLAIEPMVNLGTRHVVQENDGWTIRTRDKKPSAHFEHTVVVRKGK 241
Cdd:TIGR00500 161 VREYCGHGIGRKFHEEPQIPNYGKKFTNVRLKEGMVFTIEPMVNTGTEEITTAADGWTVKTKDGSLSAQFEHTIVITDNG 240


                  ....*
gi 937829661  242 AEILT 246
Cdd:TIGR00500 241 PEILT 245
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 11-239 5.53e-49

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 160.48  E-value: 5.53e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661   11 ELIKQSANILSQVHGEIAKHVSEGVTTLKLDSIAEEFISDHGGSpsfkGYNGFKHSLCISLNSAVVHGIPSKYALQSGDV 90
Cdd:pfam00557   1 ELMRKAARIAAAALEAALAAIRPGVTERELAAELEAARLRRGGA----RGPAFPPIVASGPNAAIPHYIPNDRVLKPGDL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661   91 VSIDCGVFFK-GFHSDSAYTHPVGDVPQEVTDLLTRTKESLYKGIEWAVAGARIGDVGHSIQTHVEQYGYG-VVRELVGH 168
Cdd:pfam00557  77 VLIDVGAEYDgGYCSDITRTFVVGKPSPEQRELYEAVLEAQEAAIAAVKPGVTGGDVDAAAREVLEEAGLGeYFPHGLGH 156

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 937829661  169 GLGRSLHESPEVPNygkRGQGLKLQDGLVLAIEPMVNlgtrhvvqENDGWtirtrdkkPSAHFEHTVVVRK 239
Cdd:pfam00557 157 GIGLEVHEGPYISR---GGDDRVLEPGMVFTIEPGIY--------FIPGW--------GGVRIEDTVLVTE 208
 
Name Accession Description Interval E-value
Map COG0024
Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];
2-251 7.14e-150

Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 439795 [Multi-domain]  Cd Length: 250  Bit Score: 417.87  E-value: 7.14e-150
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661   2 IIYKTEEEIELIKQSANILSQVHGEIAKHVSEGVTTLKLDSIAEEFISDHGGSPSFKGYNGFKHSLCISLNSAVVHGIPS 81
Cdd:COG0024    1 IEIKTPEEIEKMREAGRIVAEVLDELAEAVKPGVTTLELDRIAEEFIRDHGAIPAFLGYYGFPKSICTSVNEVVVHGIPS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661  82 KYALQSGDVVSIDCGVFFKGFHSDSAYTHPVGDVPQEVTDLLTRTKESLYKGIEWAVAGARIGDVGHSIQTHVEQYGYGV 161
Cdd:COG0024   81 DRVLKDGDIVNIDVGAILDGYHGDSARTFVVGEVSPEARRLVEVTEEALYAGIAAAKPGNRLGDIGHAIQSYAESNGYSV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661 162 VRELVGHGLGRSLHESPEVPNYGKRGQGLKLQDGLVLAIEPMVNLGTRHVVQENDGWTIRTRDKKPSAHFEHTVVVRKGK 241
Cdd:COG0024  161 VREFVGHGIGREMHEEPQVPNYGRPGRGPRLKPGMVLAIEPMINAGTPEVKVLDDGWTVVTKDGSLSAQFEHTVAVTEDG 240

                        250
                 ....*....|
gi 937829661 242 AEILTTFDYI 251
Cdd:COG0024  241 PEILTLPDGG 250
PRK05716 PRK05716
methionine aminopeptidase; Validated
 1-246 4.09e-125

methionine aminopeptidase; Validated


Pssm-ID: 235576 [Multi-domain]  Cd Length: 252  Bit Score: 355.60  E-value: 4.09e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661   1 MIIYKTEEEIELIKQSANILSQVHGEIAKHVSEGVTTLKLDSIAEEFISDHGGSPSFKGYNGFKHSLCISLNSAVVHGIP 80
Cdd:PRK05716   2 AITIKTPEEIEKMRVAGRLAAEVLDEIEPHVKPGVTTKELDRIAEEYIRDQGAIPAPLGYHGFPKSICTSVNEVVCHGIP 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661  81 SKYALQSGDVVSIDCGVFFKGFHSDSAYTHPVGDVPQEVTDLLTRTKESLYKGIEWAVAGARIGDVGHSIQTHVEQYGYG 160
Cdd:PRK05716  82 SDKVLKEGDIVNIDVTVIKDGYHGDTSRTFGVGEISPEDKRLCEVTKEALYLGIAAVKPGARLGDIGHAIQKYAEAEGFS 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661 161 VVRELVGHGLGRSLHESPEVPNYGKRGQGLKLQDGLVLAIEPMVNLGTRHVVQENDGWTIRTRDKKPSAHFEHTVVVRKG 240
Cdd:PRK05716 162 VVREYCGHGIGRKFHEEPQIPHYGAPGDGPVLKEGMVFTIEPMINAGKREVKTLKDGWTVVTKDGSLSAQYEHTVAVTED 241


                 ....*.
gi 937829661 241 KAEILT 246
Cdd:PRK05716 242 GPEILT 247
MetAP1 cd01086
Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 10-246 4.53e-123

Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238519 [Multi-domain]  Cd Length: 238  Bit Score: 349.87  E-value: 4.53e-123
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661  10 IELIKQSANILSQVHGEIAKHVSEGVTTLKLDSIAEEFISDHGGSPSFKGYNGFKHSLCISLNSAVVHGIPSKYALQSGD 89
Cdd:cd01086    1 IEGMREAGRIVAEVLDELAKAIKPGVTTKELDQIAHEFIEEHGAYPAPLGYYGFPKSICTSVNEVVCHGIPDDRVLKDGD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661  90 VVSIDCGVFFKGFHSDSAYTHPVGDVPQEVTDLLTRTKESLYKGIEWAVAGARIGDVGHSIQTHVEQYGYGVVRELVGHG 169
Cdd:cd01086   81 IVNIDVGVELDGYHGDSARTFIVGEVSEEAKKLVEVTEEALYKGIEAVKPGNRIGDIGHAIEKYAEKNGYSVVREFGGHG 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 937829661 170 LGRSLHESPEVPNYGKRGQGLKLQDGLVLAIEPMVNLGTRHVVQENDGWTIRTRDKKPSAHFEHTVVVRKGKAEILT 246
Cdd:cd01086  161 IGRKFHEEPQIPNYGRPGTGPKLKPGMVFTIEPMINLGTYEVVTLPDGWTVVTKDGSLSAQFEHTVLITEDGPEILT 237
met_pdase_I TIGR00500
methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. ...
 2-246 2.23e-102

methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. Bacterial and organellar examples (type I) differ from eukaroytic and archaeal (type II) examples in lacking a region of approximately 60 amino acids between the 4th and 5th cobalt-binding ligands. This model describes type I. The role of this protein in general is to produce the mature form of cytosolic proteins by removing the N-terminal methionine. [Protein fate, Protein modification and repair]


Pssm-ID: 129591 [Multi-domain]  Cd Length: 247  Bit Score: 297.72  E-value: 2.23e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661    2 IIYKTEEEIELIKQSANILSQVHGEIAKHVSEGVTTLKLDSIAEEFISDHGGSPSFKGYNGFKHSLCISLNSAVVHGIPS 81
Cdd:TIGR00500   1 ISLKSPDEIEKIRKAGRLAAEVLEELEREVKPGVSTKELDRIAKDFIEKHGAKPAFLGYYGFPGSVCISVNEVVIHGIPD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661   82 KYALQSGDVVSIDCGVFFKGFHSDSAYTHPVGDVPQEVTDLLTRTKESLYKGIEWAVAGARIGDVGHSIQTHVEQYGYGV 161
Cdd:TIGR00500  81 KKVLKDGDIVNIDVGVIYDGYHGDTAKTFLVGKISPEAEKLLECTEESLYKAIEEAKPGNRIGEIGAAIQKYAEAKGFSV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661  162 VRELVGHGLGRSLHESPEVPNYGKRGQGLKLQDGLVLAIEPMVNLGTRHVVQENDGWTIRTRDKKPSAHFEHTVVVRKGK 241
Cdd:TIGR00500 161 VREYCGHGIGRKFHEEPQIPNYGKKFTNVRLKEGMVFTIEPMVNTGTEEITTAADGWTVKTKDGSLSAQFEHTIVITDNG 240


                  ....*
gi 937829661  242 AEILT 246
Cdd:TIGR00500 241 PEILT 245
PRK12896 PRK12896
methionine aminopeptidase; Reviewed
 1-246 6.39e-100

methionine aminopeptidase; Reviewed


Pssm-ID: 237252 [Multi-domain]  Cd Length: 255  Bit Score: 291.74  E-value: 6.39e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661   1 MIIyKTEEEIELIKQSANILSQVHGEIAKHVSEGVTTLKLDSIAEEFISDHGGSPSFKGYNGFKHSLCISLNSAVVHGIP 80
Cdd:PRK12896   8 MEI-KSPRELEKMRKIGRIVATALKEMGKAVEPGMTTKELDRIAEKRLEEHGAIPSPEGYYGFPGSTCISVNEEVAHGIP 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661  81 SKYALQSGDVVSIDCGVFFKGFHSDSAYTHPVGDVPQEVTDLLTRTKESLYKGIEWAVAGARIGDVGHSIQTHVEQYGYG 160
Cdd:PRK12896  87 GPRVIKDGDLVNIDVSAYLDGYHGDTGITFAVGPVSEEAEKLCRVAEEALWAGIKQVKAGRPLNDIGRAIEDFAKKNGYS 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661 161 VVRELVGHGLGRSLHESPEVPN-YGKRGQGLKLQDGLVLAIEPMVNLGTRHVVQENDGWTIRTRDKKPSAHFEHTVVVRK 239
Cdd:PRK12896 167 VVRDLTGHGVGRSLHEEPSVILtYTDPLPNRLLRPGMTLAVEPFLNLGAKDAETLDDGWTVVTPDKSLSAQFEHTVVVTR 246


                 ....*..
gi 937829661 240 GKAEILT 246
Cdd:PRK12896 247 DGPEILT 253
PRK12897 PRK12897
type I methionyl aminopeptidase;
1-248 3.15e-79

type I methionyl aminopeptidase;


Pssm-ID: 171806  Cd Length: 248  Bit Score: 239.17  E-value: 3.15e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661   1 MIIYKTEEEIELIKQSANILSQVHGEIAKHVSEGVTTLKLDSIAEEFISDHGGSPSFKGYNGFKHSLCISLNSAVVHGIP 80
Cdd:PRK12897   1 MITIKTKNEIDLMHESGKLLASCHREIAKIMKPGITTKEINTFVEAYLEKHGATSEQKGYNGYPYAICASVNDEMCHAFP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661  81 SKYALQSGDVVSIDCGVFFKGFHSDSAYTHPVGDVPQEVTDLLTRTKESLYKGIEWAVAGARIGDVGHSIQTHVEQYGYG 160
Cdd:PRK12897  81 ADVPLTEGDIVTIDMVVNLNGGLSDSAWTYRVGKVSDEAEKLLLVAENALYKGIDQAVIGNRVGDIGYAIESYVANEGFS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661 161 VVRELVGHGLGRSLHESPEVPNYGKRGQGLKLQDGLVLAIEPMVNLGTRHVVQENDGWTIRTRDKKPSAHFEHTVVVRKG 240
Cdd:PRK12897 161 VARDFTGHGIGKEIHEEPAIFHFGKQGQGPELQEGMVITIEPIVNVGMRYSKVDLNGWTARTMDGKLSAQYEHTIAITKD 240


                 ....*...
gi 937829661 241 KAEILTTF 248
Cdd:PRK12897 241 GPIILTKL 248
PRK07281 PRK07281
methionyl aminopeptidase;
1-247 1.08e-56

methionyl aminopeptidase;


Pssm-ID: 180918  Cd Length: 286  Bit Score: 182.74  E-value: 1.08e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661   1 MIIYKTEEEIELIKQSANILSQVHGEIAKHVSEGVTTLKLDSIAEEFISDHGGSPSFKGYNG----FKHSLCISLNSAVV 76
Cdd:PRK07281   1 MITLKSAREIEAMDRAGDFLASIHIGLRDLIKPGVDMWEVEEYVRRRCKEENVLPLQIGVDGammdYPYATCCGLNDEVA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661  77 HGIPSKYALQSGDVVSIDCGV---------------------------FFKGFHSDSAYTHPVGDVPQEVTDLLTRTKES 129
Cdd:PRK07281  81 HAFPRHYILKEGDLLKVDMVLsepldksivdvsklnfdnveqmkkyteSYRGGLADSCWAYAVGTPSDEVKNLMDVTKEA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661 130 LYKGIEWAVAGARIGDVGHSIQTHVEQYGYGVVRELVGHGLGRSLHESPEVPNYGKRGQGLKLQDGLVLAIEPMVNLGTR 209
Cdd:PRK07281 161 MYRGIEQAVVGNRIGDIGAAIQEYAESRGYGVVRDLVGHGVGPTMHEEPMVPNYGTAGRGLRLREGMVLTIEPMINTGTW 240

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 937829661 210 HVVQE-NDGWTIRTRDKKPSAHFEHTVVVRKGKAEILTT 247
Cdd:PRK07281 241 EIDTDmKTGWAHKTLDGGLSCQYEHQFVITKDGPVILTS 279
PLN03158 PLN03158
methionine aminopeptidase; Provisional
 5-247 4.48e-54

methionine aminopeptidase; Provisional


Pssm-ID: 215607 [Multi-domain]  Cd Length: 396  Bit Score: 179.26  E-value: 4.48e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661   5 KTEEEIELIKQSANILSQVHGEIAKHVSEGVTTLKLDSIAEEFISDHGGSPSFKGYNGFKHSLCISLNSAVVHGIPSKYA 84
Cdd:PLN03158 138 KTPEQIQRMRETCRIAREVLDAAARAIKPGVTTDEIDRVVHEATIAAGGYPSPLNYHFFPKSCCTSVNEVICHGIPDARK 217

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661  85 LQSGDVVSIDCGVFFKGFHSDSAYTHPVGDVPQEVTDLLTRTKESLYKGIEWAVAGARIGDVGHSIQTHVEQYGYGVVRE 164
Cdd:PLN03158 218 LEDGDIVNVDVTVYYKGCHGDLNETFFVGNVDEASRQLVKCTYECLEKAIAIVKPGVRYREVGEVINRHATMSGLSVVKS 297

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661 165 LVGHGLGRSLHESPEVPNYGKRGQGLKLQDGLVLAIEPMVNLGTRHVVQENDGWTIRTRDKKPSAHFEHTVVVRKGKAEI 244
Cdd:PLN03158 298 YCGHGIGELFHCAPNIPHYARNKAVGVMKAGQVFTIEPMINAGVWRDRMWPDGWTAVTADGKRSAQFEHTLLVTETGVEV 377


                 ...
gi 937829661 245 LTT 247
Cdd:PLN03158 378 LTA 380
PRK12318 PRK12318
methionyl aminopeptidase;
2-249 4.00e-52

methionyl aminopeptidase;


Pssm-ID: 183434 [Multi-domain]  Cd Length: 291  Bit Score: 171.16  E-value: 4.00e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661   2 IIYKTEEEIELIKQSANILSQVHGEIAKHVSEGVTTLKLDSIAEEFISDHGGSPSFKGYNG--FKHSLCISLNSAVVHGI 79
Cdd:PRK12318  41 IIIKTPEQIEKIRKACQVTARILDALCEAAKEGVTTNELDELSRELHKEYNAIPAPLNYGSppFPKTICTSLNEVICHGI 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661  80 PSKYALQSGDVVSIDCGVFFKGFHSDSAYTHPVGDVPQEVTDLLTRTKESLYKGIEWAVAGARIGDVGHSIQTHVEQYGY 159
Cdd:PRK12318 121 PNDIPLKNGDIMNIDVSCIVDGYYGDCSRMVMIGEVSEIKKKVCQASLECLNAAIAILKPGIPLYEIGEVIENCADKYGF 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661 160 GVVRELVGHGLGRSLHESPEVPNYGKRGQgLKLQDGLVLAIEPMVNLGTRH-VVQENDGWTIRTRDKKPSAHFEHTVVVR 238
Cdd:PRK12318 201 SVVDQFVGHGVGIKFHENPYVPHHRNSSK-IPLAPGMIFTIEPMINVGKKEgVIDPINHWEARTCDNQPSAQWEHTILIT 279

                        250
                 ....*....|.
gi 937829661 239 KGKAEILTTFD 249
Cdd:PRK12318 280 ETGYEILTLLD 290
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 11-239 5.53e-49

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 160.48  E-value: 5.53e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661   11 ELIKQSANILSQVHGEIAKHVSEGVTTLKLDSIAEEFISDHGGSpsfkGYNGFKHSLCISLNSAVVHGIPSKYALQSGDV 90
Cdd:pfam00557   1 ELMRKAARIAAAALEAALAAIRPGVTERELAAELEAARLRRGGA----RGPAFPPIVASGPNAAIPHYIPNDRVLKPGDL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661   91 VSIDCGVFFK-GFHSDSAYTHPVGDVPQEVTDLLTRTKESLYKGIEWAVAGARIGDVGHSIQTHVEQYGYG-VVRELVGH 168
Cdd:pfam00557  77 VLIDVGAEYDgGYCSDITRTFVVGKPSPEQRELYEAVLEAQEAAIAAVKPGVTGGDVDAAAREVLEEAGLGeYFPHGLGH 156

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 937829661  169 GLGRSLHESPEVPNygkRGQGLKLQDGLVLAIEPMVNlgtrhvvqENDGWtirtrdkkPSAHFEHTVVVRK 239
Cdd:pfam00557 157 GIGLEVHEGPYISR---GGDDRVLEPGMVFTIEPGIY--------FIPGW--------GGVRIEDTVLVTE 208
PepP COG0006
Xaa-Pro aminopeptidase [Amino acid transport and metabolism];
4-248 1.25e-35

Xaa-Pro aminopeptidase [Amino acid transport and metabolism];


Pssm-ID: 439777 [Multi-domain]  Cd Length: 299  Bit Score: 128.40  E-value: 1.25e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661   4 YKTEEEIELIKQSANILSQVHGEIAKHVSEGVTTLKLDSIAEEFISDHGG-SPSFKGYNGFKHslcislNSAVVHGIPSK 82
Cdd:COG0006   73 IKSPEEIELMRKAARIADAAHEAALAALRPGVTEREVAAELEAAMRRRGAeGPSFDTIVASGE------NAAIPHYTPTD 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661  83 YALQSGDVVSIDCGVFFKGFHSDSAYTHPVGDVPQEVTDLLTRTKESLYKGIEWAVAGARIGDVGHSIQTHVEQYGYGvv 162
Cdd:COG0006  147 RPLKPGDLVLIDAGAEYDGYTSDITRTVAVGEPSDEQREIYEAVLEAQEAAIAALKPGVTGGEVDAAARDVLAEAGYG-- 224

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661 163 RELV---GHGLGRSLHESPEVpnygKRGQGLKLQDGLVLAIEPMvnlgtrhvVQENDGWTIRTrdkkpsahfEHTVVVRK 239
Cdd:COG0006  225 EYFPhgtGHGVGLDVHEGPQI----SPGNDRPLEPGMVFTIEPG--------IYIPGIGGVRI---------EDTVLVTE 283


                 ....*....
gi 937829661 240 GKAEILTTF 248
Cdd:COG0006  284 DGAEVLTRL 292
met_pdase_II TIGR00501
methionine aminopeptidase, type II; Methionine aminopeptidase (map) is a cobalt-binding enzyme. ...
 8-227 3.03e-32

methionine aminopeptidase, type II; Methionine aminopeptidase (map) is a cobalt-binding enzyme. Bacterial and organellar examples (type I) differ from eukaroytic and archaeal (type II) examples in lacking a region of approximately 60 amino acids between the 4th and 5th cobalt-binding ligands. The role of this protein in general is to produce the mature amino end of cytosolic proteins by removing the N-terminal methionine. This model describes type II, among which the eukaryotic members typically have an N-terminal extension not present in archaeal members. It can act cotranslationally. The enzyme from rat has been shown to associate with translation initiation factor 2 (IF-2) and may have a role in translational regulation. [Protein fate, Protein modification and repair]


Pssm-ID: 129592  Cd Length: 295  Bit Score: 119.50  E-value: 3.03e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661    8 EEIELIKQSANILSQVHGEIAKHVSEGVTTLKLDSIAEEFISDHGGSPSFKgyngfkhslC-ISLNSAVVHGIPS---KY 83
Cdd:TIGR00501   3 ERAEKWIEAGKIHSKVRREAADRIVPGVKLLEVAEFVENRIRELGAEPAFP---------CnISINECAAHFTPKagdKT 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661   84 ALQSGDVVSIDCGVFFKGFHSDSAYTHPVGDVpqeVTDLLTRTKESLYKGIEWAVAGARIGDVGHSIQTHVEQYGYGVVR 163
Cdd:TIGR00501  74 VFKDGDVVKLDLGAHVDGYIADTAITVDLGDQ---YDNLVKAAKDALYTAIKEIRAGVRVGEIGKAIQEVIESYGVKPIS 150

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 937829661  164 ELVGHGLGR-SLHESPEVPNYgKRGQGLKLQDGLVLAIEPMVNLGTRHVVQENDGWTIRTRDKKP 227
Cdd:TIGR00501 151 NLTGHSMAPyRLHGGKSIPNV-KERDTTKLEEGDVVAIEPFATDGVGYVTDGGEVSIYAFLAERP 214
MetAP2 cd01088
Methionine Aminopeptidase 2. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 10-246 2.12e-31

Methionine Aminopeptidase 2. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238521 [Multi-domain]  Cd Length: 291  Bit Score: 117.35  E-value: 2.12e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661  10 IELIKQSANILSQVHGEIAKHVSEGVTTLKLDSIAEEFISDHGGSPSFkgyngfkhSLCISLNSAVVHGIPS---KYALQ 86
Cdd:cd01088    1 LEKYREAGEIHRQVRKYAQSLIKPGMTLLEIAEFVENRIRELGAGPAF--------PVNLSINECAAHYTPNagdDTVLK 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661  87 SGDVVSIDCGVFFKGFHSDSAYTHPVGDvpqEVTDLLTRTKESLYKGIEWAVAGARIGDVGHSIQTHVEQYGYGVVRELV 166
Cdd:cd01088   73 EGDVVKLDFGAHVDGYIADSAFTVDFDP---KYDDLLEAAKEALNAAIKEAGPDVRLGEIGEAIEEVIESYGFKPIRNLT 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661 167 GHGLGR-SLHESPEVPNYGKRGQGlKLQDGLVLAIEPMVNLGT-------------------------RHVVQ---ENDG 217
Cdd:cd01088  150 GHSIERyRLHAGKSIPNVKGGEGT-RLEEGDVYAIEPFATTGKgyvhdgpecsiymlnrdkplrlpraRKLLDviyENFG 228

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 937829661 218 W---------------------------------TIRTRDKKPSAHFEHTVVVRKGKAEILT 246
Cdd:cd01088  229 TlpfarrwldrlgetkllmalknlckagivypypVLKEISGGYVAQFEHTIIVREDGKEVTT 290
APP_MetAP cd01066
A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as ...
 10-242 3.61e-27

A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity compared to other metallo-aminopeptidases, suggesting they play roles in regulation of biological processes rather than general protein degradation.


Pssm-ID: 238514 [Multi-domain]  Cd Length: 207  Bit Score: 104.07  E-value: 3.61e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661  10 IELIKQSANILSQVHGEIAKHVSEGVTTLKLDSIAEEFISDHGGSPSfkgyngfkHSLCISLN--SAVVHGIPSKYALQS 87
Cdd:cd01066    1 IARLRKAAEIAEAAMAAAAEAIRPGVTEAEVAAAIEQALRAAGGYPA--------GPTIVGSGarTALPHYRPDDRRLQE 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661  88 GDVVSIDCGVFFKGFHSDSAYTHPVGDVPQEVTDLLTRTKESLYKGIEWAVAGARIGDVGHSIQTHVEQYGYGVVR-ELV 166
Cdd:cd01066   73 GDLVLVDLGGVYDGYHADLTRTFVIGEPSDEQRELYEAVREAQEAALAALRPGVTAEEVDAAAREVLEEHGLGPNFgHRT 152

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 937829661 167 GHGLGRSLHESPevpnYGKRGQGLKLQDGLVLAIEPMVNLGtrhvvqenDGWTIRtrdkkpsahFEHTVVVRKGKA 242
Cdd:cd01066  153 GHGIGLEIHEPP----VLKAGDDTVLEPGMVFAVEPGLYLP--------GGGGVR---------IEDTVLVTEDGP 207
APP-like cd01092
Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse ...
 10-202 1.13e-22

Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline.


Pssm-ID: 238525 [Multi-domain]  Cd Length: 208  Bit Score: 92.19  E-value: 1.13e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661  10 IELIKQSANILSQVHGEIAKHVSEGVTTLKLDSIAEEFISDHGGS-PSF-----KGYNgfkhslcislnSAVVHGIPSKY 83
Cdd:cd01092    1 IELLRKAARIADKAFEELLEFIKPGMTEREVAAELEYFMRKLGAEgPSFdtivaSGPN-----------SALPHGVPSDR 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661  84 ALQSGDVVSIDCGVFFKGFHSDSAYTHPVGDVPQEVTDLLTRTKESLYKGIEWAVAGARIGDVGHSIQTHVEQYGYG--- 160
Cdd:cd01092   70 KIEEGDLVLIDFGAIYDGYCSDITRTVAVGEPSDELKEIYEIVLEAQQAAIKAVKPGVTAKEVDKAARDVIEEAGYGeyf 149

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 937829661 161 VVRelVGHGLGRSLHESPEVPNYGKrgqgLKLQDGLVLAIEP 202
Cdd:cd01092  150 IHR--TGHGVGLEVHEAPYISPGSD----DVLEEGMVFTIEP 185
PTZ00053 PTZ00053
methionine aminopeptidase 2; Provisional
 6-216 1.57e-11

methionine aminopeptidase 2; Provisional


Pssm-ID: 240246 [Multi-domain]  Cd Length: 470  Bit Score: 63.58  E-value: 1.57e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661   6 TEEEIELIKQSANILSQVHGEIAKHVSEGVTTL----KLDSIAEEFISDHGgspsFKGYNGFKHSLciSLNSAVVHGIPS 81
Cdd:PTZ00053 154 SEEQYQDLRRAAEVHRQVRRYAQSVIKPGVKLIdiceRIESKSRELIEADG----LKCGWAFPTGC--SLNHCAAHYTPN 227

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661  82 ---KYALQSGDVVSIDCGVFFKGFHSDSAYT---HPVGDvpqevtDLLTRTKESLYKGIEWAVAGARIGDVGHSIQTHVE 155
Cdd:PTZ00053 228 tgdKTVLTYDDVCKLDFGTHVNGRIIDCAFTvafNPKYD------PLLQATKDATNTGIKEAGIDVRLSDIGAAIQEVIE 301

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 937829661 156 QY-------GYGV--VRELVGHGLGR-SLHESPEVPNYGKRGQGlKLQDGLVLAIEPMVNLGTRHVVQEND 216
Cdd:PTZ00053 302 SYeveikgkTYPIksIRNLNGHSIGPyIIHGGKSVPIVKGGENT-RMEEGELFAIETFASTGRGYVNEDLE 371
PRK10879 PRK10879
proline aminopeptidase P II; Provisional
 1-202 1.17e-08

proline aminopeptidase P II; Provisional


Pssm-ID: 182804 [Multi-domain]  Cd Length: 438  Bit Score: 55.12  E-value: 1.17e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661   1 MIIYKTEEEIELIKQSANILSQVHGEIAKHVSEGVTTLKLDS-IAEEFISDHGGSPSFKGYNGFKHSLCIslnsavVHGI 79
Cdd:PRK10879 170 MRLFKSPEEIAVLRRAGEISALAHTRAMEKCRPGMFEYQLEGeIHHEFNRHGARYPSYNTIVGSGENGCI------LHYT 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661  80 PSKYALQSGDVVSIDCGVFFKGFHSDSAYTHPVG---DVPQ-EVTDLLTrtkESLYKGIEWAVAGARIGDV-GHSIQTHV 154
Cdd:PRK10879 244 ENESEMRDGDLVLIDAGCEYKGYAGDITRTFPVNgkfTPAQrEIYDIVL---ESLETSLRLYRPGTSIREVtGEVVRIMV 320

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 937829661 155 E---QYG--YGVVRELV-------------GHGLGRSLHespEVPNYGKRgQGLKLQDGLVLAIEP 202
Cdd:PRK10879 321 SglvKLGilKGDVDQLIaenahrpffmhglSHWLGLDVH---DVGVYGQD-RSRILEPGMVLTVEP 382
crvDNA_42K TIGR00495
42K curved DNA binding protein; Proteins identified by this model have been identified in a ...
 25-249 2.99e-08

42K curved DNA binding protein; Proteins identified by this model have been identified in a number of species as a nuclear (but not nucleolar) protein with a cell cycle dependence. Various names given to members of this family have included cell cycle protein p38-2G4, DNA-binding protein GBP16, and proliferation-associated protein 1. This protein is closely related to methionine aminopeptidase, a cobolt-binding protein. [Unknown function, General]


Pssm-ID: 273105  Cd Length: 390  Bit Score: 53.74  E-value: 2.99e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661   25 GEIA----KHVSE----GVTTLKLDSIAEEFISDHGGSpSFKG----YNGFKHSLCISLNSAVVHGIPSK----YALQSG 88
Cdd:TIGR00495  27 GEIAnnvlKSVVEacspGAKVVDICEKGDAFIMEETAK-IFKKekemEKGIAFPTCISVNNCVGHFSPLKsdqdYILKEG 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661   89 DVVSIDCGVFFKGFHSDSAYTHPVGDVPQE-----VTDLLTRTKESLYKGIEWAVAGARIGDVGHSIQTHVEQYGYGVVR 163
Cdd:TIGR00495 106 DVVKIDLGCHIDGFIALVAHTFVVGVAQEEpvtgrKADVIAAAHLAAEAALRLVKPGNTNTQVTEAINKVAHSYGCTPVE 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661  164 ELVGHGLGRSLHESPEV------PNYGKRGQGLKLQDGLVLAIEPMVNLGTRHVVQENDGWTIRTRDkkPSAHFE-HTVV 236
Cdd:TIGR00495 186 GMLSHQLKQHVIDGEKViisnpsDSQKKDHDTAEFEENEVYAVDILVSTGEGKAKDADQRTTIYKRD--PSKTYGlKMKA 263

                         250
                  ....*....|...
gi 937829661  237 VRKGKAEILTTFD 249
Cdd:TIGR00495 264 SRAFFSEIERRFD 276
PRK15173 PRK15173
peptidase; Provisional
 3-201 3.10e-07

peptidase; Provisional


Pssm-ID: 185095 [Multi-domain]  Cd Length: 323  Bit Score: 50.49  E-value: 3.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661   3 IYKTEEEIELIKQSANILSQVHGEIAKHVSEGVTTLKLDSIAEEFISDhggspsfKGYNGFKHSLCISLNSAVVHG-IPS 81
Cdd:PRK15173  94 VIKSPWEIKRLRKSAEITEYGITEASKLIRVGCTSAELTAAYKAAVMS-------KSETHFSRFHLISVGADFSPKlIPS 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661  82 KYALQSGDVVSIDCGVFFKGFHSDSAYTHPVGDvPQEVTDLLTRTKESLYKGIEWAVA-GARIGDVGHSIQTHVEQYGY- 159
Cdd:PRK15173 167 NTKACSGDLIKFDCGVDVDGYGADIARTFVVGE-PPEITRKIYQTIRTGHEHMLSMVApGVKMKDVFDSTMEVIKKSGLp 245

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 937829661 160 GVVRELVGHGLG--RSLHESPEVPNYGKRgqglKLQDGLVLAIE 201
Cdd:PRK15173 246 NYNRGHLGHGNGvfLGLEESPFVSTHATE----SFTSGMVLSLE 285
PRK14575 PRK14575
putative peptidase; Provisional
 3-201 5.39e-07

putative peptidase; Provisional


Pssm-ID: 173039 [Multi-domain]  Cd Length: 406  Bit Score: 50.09  E-value: 5.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661   3 IYKTEEEIELIKQSANILSQVHGEIAKHVSEGVTTLKLDSIAEEFISDhggspsfKGYNGFKHSLCISLNSAVVHG-IPS 81
Cdd:PRK14575 177 VIKSPWEIKRLRKSAEITEYGITEASKLIRVGCTSAELTAAYKAAVMS-------KSETHFSRFHLISVGADFSPKlIPS 249

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661  82 KYALQSGDVVSIDCGVFFKGFHSDSAYTHPVGDvPQEVTDLLTRTKESLYKGIEWAVA-GARIGDVGHSIQTHVEQYGY- 159
Cdd:PRK14575 250 NTKACSGDLIKFDCGVDVDGYGADIARTFVVGE-PPEITRKIYQTIRTGHEHMLSMVApGVKMKDVFDSTMEVIKKSGLp 328

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 937829661 160 GVVRELVGHGLG--RSLHESPEVPNYGKRgqglKLQDGLVLAIE 201
Cdd:PRK14575 329 NYNRGHLGHGNGvfLGLEESPFVSTHATE----SFTSGMVLSLE 368
Prolidase cd01087
Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline ...
 10-202 1.50e-05

Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro.


Pssm-ID: 238520 [Multi-domain]  Cd Length: 243  Bit Score: 44.87  E-value: 1.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661  10 IELIKQSANILSQVHGEIAKHVSEGVTTLKLDSIAE-EFISdHGGSPSFkGYNgfkhslCIS-LNSAVVHGIPSKYALQS 87
Cdd:cd01087    1 IELMRKACDISAEAHRAAMKASRPGMSEYELEAEFEyEFRS-RGARLAY-SYI------VAAgSNAAILHYVHNDQPLKD 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661  88 GDVVSIDCGVFFKGFHSDSAYTHPVG----DVPQEVTDLLTRTKEslyKGIEWAVAGARIGDV-GHSIQTHVE---QYG- 158
Cdd:cd01087   73 GDLVLIDAGAEYGGYASDITRTFPVNgkftDEQRELYEAVLAAQK---AAIAACKPGVSYEDIhLLAHRVLAEglkELGi 149

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 937829661 159 -YGVVRELV-------------GHGLGRSLHespEVPNYGKR-GQGLKLQDGLVLAIEP 202
Cdd:cd01087  150 lKGDVDEIVesgayakffphglGHYLGLDVH---DVGGYLRYlRRARPLEPGMVITIEP 205
PRK14576 PRK14576
putative endopeptidase; Provisional
 5-215 5.43e-04

putative endopeptidase; Provisional


Pssm-ID: 173040 [Multi-domain]  Cd Length: 405  Bit Score: 40.77  E-value: 5.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661   5 KTEEEIELIKQSANILSQVHGEIAKHVSEGVTTLKLDSIAEEFISdhggspSFKGYNGFKHSLCISLNSAVVHGIPSKYA 84
Cdd:PRK14576 178 KSPWEIEHLRKSAEITEYGIASAAKKIRVGCTAAELTAAFKAAVM------SFPETNFSRFNLISVGDNFSPKIIADTTP 251

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 937829661  85 LQSGDVVSIDCGVFFKGFHSDSAYTHPVGDvPQEVTDLLTRTKESLYKGIEWAVA-GARIGDVGHSIQTHVEQYGY-GVV 162
Cdd:PRK14576 252 AKVGDLIKFDCGIDVAGYGADLARTFVLGE-PDKLTQQIYDTIRTGHEHMLSMVApGVKLKAVFDSTMAVIKTSGLpHYN 330

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 937829661 163 RELVGHGLG--RSLHESPEVPNYGKRgqglKLQDGLVLAIE-PMVNLGTRHVVQEN 215
Cdd:PRK14576 331 RGHLGHGDGvfLGLEEVPFVSTQATE----TFCPGMVLSLEtPYYGIGVGSIMLED 382
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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