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Conserved domains on  [gi|923042908|gb|ALB05674|]
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QacH, partial [Klebsiella variicola]

Protein Classification

DMT family transporter( domain architecture ID 10005269)

DMT (drug/metabolite transporter) family transporter is an inner membrane protein involved in the transport of one or more of a variety of substrates such as amino acids, drugs, metabolites, and sugar phosphates, among others

Gene Ontology:  GO:0055085|GO:0022857|GO:0016020
PubMed:  11432728
TCDB:  2.A.7

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EmrE COG2076
Multidrug transporter EmrE and related cation transporters [Defense mechanisms];
1-61 5.75e-14

Multidrug transporter EmrE and related cation transporters [Defense mechanisms];


:

Pssm-ID: 441679  Cd Length: 105  Bit Score: 60.11  E-value: 5.75e-14
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 923042908   1 GLAFYFLSLALKSIPVGIAYAVWAGLGIVLVAAIAWIFHGQKLNFWAFIGIGLIVSGVAVL 61
Cdd:COG2076   39 ALSFYLLSLALKTLPVGTAYAVWTGIGAVGTALVGILLFGEPLSLARLLGIALIIAGVVGL 99
 
Name Accession Description Interval E-value
EmrE COG2076
Multidrug transporter EmrE and related cation transporters [Defense mechanisms];
1-61 5.75e-14

Multidrug transporter EmrE and related cation transporters [Defense mechanisms];


Pssm-ID: 441679  Cd Length: 105  Bit Score: 60.11  E-value: 5.75e-14
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 923042908   1 GLAFYFLSLALKSIPVGIAYAVWAGLGIVLVAAIAWIFHGQKLNFWAFIGIGLIVSGVAVL 61
Cdd:COG2076   39 ALSFYLLSLALKTLPVGTAYAVWTGIGAVGTALVGILLFGEPLSLARLLGIALIIAGVVGL 99
emrE PRK09541
EmrE family multidrug efflux SMR transporter;
3-61 4.89e-12

EmrE family multidrug efflux SMR transporter;


Pssm-ID: 137367  Cd Length: 110  Bit Score: 55.74  E-value: 4.89e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 923042908   3 AFYFLSLALKSIPVGIAYAVWAGLGIVLVAAIAWIFHGQKLNFWAFIGIGLIVSGVAVL 61
Cdd:PRK09541  43 SFWLLAQTLAYIPTGIAYAIWSGVGIVLISLLSWGFFGQRLDLPAIIGMMLICAGVLVI 101
Multi_Drug_Res pfam00893
Small Multidrug Resistance protein; This family is the Small Multidrug Resistance (SMR) family. ...
 1-54 5.72e-10

Small Multidrug Resistance protein; This family is the Small Multidrug Resistance (SMR) family. Several members have been shown to export a range of toxins, including ethidium bromide and quaternary ammonium compounds, through coupling with proton influx.


Pssm-ID: 459985  Cd Length: 93  Bit Score: 49.98  E-value: 5.72e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 923042908   1 GLAFYFLSLALKSIPVGIAYAVWAGLGIVLVAAIAWIFHGQKLNFWAFIGIGLI 54
Cdd:pfam00893 40 GLSFYLLSLALKSIPLGVAYAVWSGIGTVGTTLVGILLFGESLSLKKVIGLGLI 93
 
Name Accession Description Interval E-value
EmrE COG2076
Multidrug transporter EmrE and related cation transporters [Defense mechanisms];
1-61 5.75e-14

Multidrug transporter EmrE and related cation transporters [Defense mechanisms];


Pssm-ID: 441679  Cd Length: 105  Bit Score: 60.11  E-value: 5.75e-14
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 923042908   1 GLAFYFLSLALKSIPVGIAYAVWAGLGIVLVAAIAWIFHGQKLNFWAFIGIGLIVSGVAVL 61
Cdd:COG2076   39 ALSFYLLSLALKTLPVGTAYAVWTGIGAVGTALVGILLFGEPLSLARLLGIALIIAGVVGL 99
emrE PRK09541
EmrE family multidrug efflux SMR transporter;
3-61 4.89e-12

EmrE family multidrug efflux SMR transporter;


Pssm-ID: 137367  Cd Length: 110  Bit Score: 55.74  E-value: 4.89e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 923042908   3 AFYFLSLALKSIPVGIAYAVWAGLGIVLVAAIAWIFHGQKLNFWAFIGIGLIVSGVAVL 61
Cdd:PRK09541  43 SFWLLAQTLAYIPTGIAYAIWSGVGIVLISLLSWGFFGQRLDLPAIIGMMLICAGVLVI 101
Multi_Drug_Res pfam00893
Small Multidrug Resistance protein; This family is the Small Multidrug Resistance (SMR) family. ...
 1-54 5.72e-10

Small Multidrug Resistance protein; This family is the Small Multidrug Resistance (SMR) family. Several members have been shown to export a range of toxins, including ethidium bromide and quaternary ammonium compounds, through coupling with proton influx.


Pssm-ID: 459985  Cd Length: 93  Bit Score: 49.98  E-value: 5.72e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 923042908   1 GLAFYFLSLALKSIPVGIAYAVWAGLGIVLVAAIAWIFHGQKLNFWAFIGIGLI 54
Cdd:pfam00893 40 GLSFYLLSLALKSIPLGVAYAVWSGIGTVGTTLVGILLFGESLSLKKVIGLGLI 93
PRK10650 PRK10650
multidrug/spermidine efflux SMR transporter subunit MdtI;
3-61 1.06e-06

multidrug/spermidine efflux SMR transporter subunit MdtI;


Pssm-ID: 182618  Cd Length: 109  Bit Score: 41.95  E-value: 1.06e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 923042908   3 AFYFLSLALKSIPVGIAYAVWAGLGIVLVAAIAWIFHGQKLNFWAFIGIGLIVSGVAVL 61
Cdd:PRK10650  48 AFSALSQAVKGIDLSVAYALWGGFGIAATLAAGWILFGQRLNRKGWIGLVLLLAGMVMI 106
PRK10452 PRK10452
multidrug/spermidine efflux SMR transporter subunit MdtJ;
2-61 6.45e-04

multidrug/spermidine efflux SMR transporter subunit MdtJ;


Pssm-ID: 182471  Cd Length: 120  Bit Score: 34.75  E-value: 6.45e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 923042908   2 LAFYFLSLALKSIPVGIAYAVWAGLGIVLVAAIAWIFHGQKLNFWAFIGIGLIVSGVAVL 61
Cdd:PRK10452  42 LSYIFLSFAVKKIALGVAYALWEGIGILFITLFSVLLFDESLSLMKIAGLTTLVAGIVLI 101
PRK11431 PRK11431
quaternary ammonium compound efflux SMR transporter SugE;
2-58 2.32e-03

quaternary ammonium compound efflux SMR transporter SugE;


Pssm-ID: 171110  Cd Length: 105  Bit Score: 32.91  E-value: 2.32e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 923042908   2 LAFYFLSLALKSIPVGIAYAVWAGLGIVLVAAIAWIFHGQKLNFWAFIGIGLIVSGV 58
Cdd:PRK11431  41 VSMALLAWAMKSLPVGTAYAVWTGIGAVGAAITGIVLLGESASPARLLSLALIVAGI 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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