NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|908216747|gb|AKS54736|]
View 

sugar ABC transporter permease [Listeria monocytogenes]

Protein Classification

sugar ABC transporter permease( domain architecture ID 10790449)

sugar ABC transporter permease is the transmembrane (TM) subunit of a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter responsible for the translocation across the membrane of one or more from a variety of sugar substrates including oligosaccharides and maltodextrin

Gene Ontology:  GO:0043190|GO:0140359|GO:0042626|GO:0016020|GO:0008643
PubMed:  25750732|24638992|18535149|17723295
TCDB:  3.A.1

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MalG COG3833
ABC-type maltose transport system, permease component MalG [Carbohydrate transport and ...
 4-283 2.68e-131

ABC-type maltose transport system, permease component MalG [Carbohydrate transport and metabolism];


:

Pssm-ID: 443045 [Multi-domain]  Cd Length: 282  Bit Score: 373.33  E-value: 2.68e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 908216747   4 FMKDQRTTKFLTQFFTYLFLTVLTIIILYPILITASSAFKPGNIAAFTLEWSDSWTLNNFTRLFNETLYLDWYKNTLIIA 83
Cdd:COG3833    3 RRKSRKRRRRLKLGLRHLVLIILAIIALFPILWVVSASFNPGGSLYSSSLIPENFTLENYKKLFTETPFLRWFLNSLIVA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 908216747  84 VVTMIMQVTIVTLAGYTYSRYRFKGRKNSLIFFLIIQMVPTMAALTAFYVLAMLLGALDQYWFLTLIYIGGGIPMNTWLM 163
Cdd:COG3833   83 VVTAIISVFLAALAAYAFSRFRFKGRKAGLLALLLLQMFPAFLALVALYLLLSALGLLNTLLGLILVYLGGAIPFNTWLM 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 908216747 164 KGYFDTVPRDLDESAKLDGAGHFRIFAQIILPLVRPMIAVQALWAFMGPFGDFLLAKFLLRTPENLTIAVGLQTFIANPQ 243
Cdd:COG3833  163 KGYFDTIPKELDEAAKIDGASHFQIFFRIILPLAKPILAVVALLSFIGPWNDFILASVLLRSPENYTLAVGLYSFVSDQR 242

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 908216747 244 QQKVALFAAGAILAALPICLLFFFLQKNFVSGLTAGGTKG 283
Cdd:COG3833  243 NTNWGVFAAGAVLVAIPIVILFLFLQRYLVSGLTAGGVKG 282
 
Name Accession Description Interval E-value
MalG COG3833
ABC-type maltose transport system, permease component MalG [Carbohydrate transport and ...
 4-283 2.68e-131

ABC-type maltose transport system, permease component MalG [Carbohydrate transport and metabolism];


Pssm-ID: 443045 [Multi-domain]  Cd Length: 282  Bit Score: 373.33  E-value: 2.68e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 908216747   4 FMKDQRTTKFLTQFFTYLFLTVLTIIILYPILITASSAFKPGNIAAFTLEWSDSWTLNNFTRLFNETLYLDWYKNTLIIA 83
Cdd:COG3833    3 RRKSRKRRRRLKLGLRHLVLIILAIIALFPILWVVSASFNPGGSLYSSSLIPENFTLENYKKLFTETPFLRWFLNSLIVA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 908216747  84 VVTMIMQVTIVTLAGYTYSRYRFKGRKNSLIFFLIIQMVPTMAALTAFYVLAMLLGALDQYWFLTLIYIGGGIPMNTWLM 163
Cdd:COG3833   83 VVTAIISVFLAALAAYAFSRFRFKGRKAGLLALLLLQMFPAFLALVALYLLLSALGLLNTLLGLILVYLGGAIPFNTWLM 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 908216747 164 KGYFDTVPRDLDESAKLDGAGHFRIFAQIILPLVRPMIAVQALWAFMGPFGDFLLAKFLLRTPENLTIAVGLQTFIANPQ 243
Cdd:COG3833  163 KGYFDTIPKELDEAAKIDGASHFQIFFRIILPLAKPILAVVALLSFIGPWNDFILASVLLRSPENYTLAVGLYSFVSDQR 242

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 908216747 244 QQKVALFAAGAILAALPICLLFFFLQKNFVSGLTAGGTKG 283
Cdd:COG3833  243 NTNWGVFAAGAVLVAIPIVILFLFLQRYLVSGLTAGGVKG 282
malG PRK10998
maltose ABC transporter permease MalG;
17-283 3.67e-49

maltose ABC transporter permease MalG;


Pssm-ID: 182891  Cd Length: 296  Bit Score: 164.50  E-value: 3.67e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 908216747  17 FFTYLFLTVLTIIILYPILITASSAFKPGNIAAFTLeWSDSWTLNNFTRLFN-------------ETLYLDWYKNTLIIA 83
Cdd:PRK10998  14 FATHLLLLGFIALIMFPLLMVIAISLREGNFATGSL-IPEQISWEHWKLALGfsvehadgrvtppPFPVLLWLWNSVKVA 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 908216747  84 VVTMIMQVTIVTLAGYTYSRYRFKGRKNSLIFFLIIQMVPTMAALTAFYVLAMLLG------ALDQYWFLTLIYIGGgIP 157
Cdd:PRK10998  93 GITAIGIVALSTTCAYAFARMRFKGKATLLKGMLIFQMFPAVLSLVALYALFDRLGqyipfiGLNTHGGVIFAYLGG-IA 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 908216747 158 MNTWLMKGYFDTVPRDLDESAKLDGAGHFRIFAQIILPLVRPMIAVQALWAFMGPFGDFLLAKFLLRTPENLTIAVGLQT 237
Cdd:PRK10998 172 LHVWTIKGYFETIDSSLEEAAALDGATPWQAFRLVLLPLSVPILAVVFILSFIAAITEVPVASLLLRDVNSYTLAVGMQQ 251

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 908216747 238 FIaNPQQQKVALFAAGAILAALPICLLFFFLQKNFVSGLTAGGTKG 283
Cdd:PRK10998 252 YL-NPQNYLWGDFAAAAVLSAIPITVVFLLAQRWLVGGLTAGGVKG 296
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 93-276 5.11e-14

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 68.86  E-value: 5.11e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 908216747   93 IVTLAGYTYSRYRFKGRKNSLIFFLIIQMVPTMAALTAFYVLAMLLGALDQYWFLTLIYIGGGIPMNTWLMKGYFDTVPR 172
Cdd:pfam00528   1 GIPLGIIAALRRGRRLDRLLRPLIDLLQALPSFVLAILLVVIAILSILGHGILPAIILALLGWAGYARLIRRAALRSLPS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 908216747  173 DLDESAKLDGAGHFRIFAQIILPLVRPMIAVQALWAFMGPFGDFLLAKFLLRTPenltiavGLQTFIANPQQQK----VA 248
Cdd:pfam00528  81 DLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWP-------GLGLLLIEAILGYdypeIQ 153

                         170       180
                  ....*....|....*....|....*...
gi 908216747  249 LFAAGAILAALPICLLFFFLQKNFVSGL 276
Cdd:pfam00528 154 GPVLAAALILLLLNLLVDILQRLLDPRV 181
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 78-261 5.62e-14

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 68.84  E-value: 5.62e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 908216747  78 NTLIIAVVTMIMQVTIVTLAGYTYSRYRFKGRKNSLIFFLIIQMVPTMAALTAFYVLAMLLGALDQYWFLTL----IYIG 153
Cdd:cd06261    3 NTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILPGLGLpaliLALL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 908216747 154 GGIPMNTWLMKGYFDTVPRDLDESAKLDGAGHFRIFAQIILPLVRPMIAVQALWAFMGPFGDFLLAKFLLrTPENLTIAV 233
Cdd:cd06261   83 LIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLG-GGEAPGPGT 161

                        170       180
                 ....*....|....*....|....*...
gi 908216747 234 GLQTFIANPQQQKVALFAAGAILAALPI 261
Cdd:cd06261  162 GLLLIFAILFPGDLGVAAAVALILLLLS 189
 
Name Accession Description Interval E-value
MalG COG3833
ABC-type maltose transport system, permease component MalG [Carbohydrate transport and ...
 4-283 2.68e-131

ABC-type maltose transport system, permease component MalG [Carbohydrate transport and metabolism];


Pssm-ID: 443045 [Multi-domain]  Cd Length: 282  Bit Score: 373.33  E-value: 2.68e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 908216747   4 FMKDQRTTKFLTQFFTYLFLTVLTIIILYPILITASSAFKPGNIAAFTLEWSDSWTLNNFTRLFNETLYLDWYKNTLIIA 83
Cdd:COG3833    3 RRKSRKRRRRLKLGLRHLVLIILAIIALFPILWVVSASFNPGGSLYSSSLIPENFTLENYKKLFTETPFLRWFLNSLIVA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 908216747  84 VVTMIMQVTIVTLAGYTYSRYRFKGRKNSLIFFLIIQMVPTMAALTAFYVLAMLLGALDQYWFLTLIYIGGGIPMNTWLM 163
Cdd:COG3833   83 VVTAIISVFLAALAAYAFSRFRFKGRKAGLLALLLLQMFPAFLALVALYLLLSALGLLNTLLGLILVYLGGAIPFNTWLM 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 908216747 164 KGYFDTVPRDLDESAKLDGAGHFRIFAQIILPLVRPMIAVQALWAFMGPFGDFLLAKFLLRTPENLTIAVGLQTFIANPQ 243
Cdd:COG3833  163 KGYFDTIPKELDEAAKIDGASHFQIFFRIILPLAKPILAVVALLSFIGPWNDFILASVLLRSPENYTLAVGLYSFVSDQR 242

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 908216747 244 QQKVALFAAGAILAALPICLLFFFLQKNFVSGLTAGGTKG 283
Cdd:COG3833  243 NTNWGVFAAGAVLVAIPIVILFLFLQRYLVSGLTAGGVKG 282
UgpE COG0395
ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and ...
 9-283 1.74e-77

ABC-type glycerol-3-phosphate transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440164 [Multi-domain]  Cd Length: 282  Bit Score: 236.53  E-value: 1.74e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 908216747   9 RTTKFLTQFFTYLFLTVLTIIILYPILITASSAFKPGN--IAAFTLEWSDSWTLNNFTRLFNETLYLDWYKNTLIIAVVT 86
Cdd:COG0395    7 RRRRRLGRILLYLLLILLALLFLFPLYWMVVTSFKPPAeiFSGPPSLLPSEFTLENYRAAFTDGPFGRYLLNSLIVAVVS 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 908216747  87 MIMQVTIVTLAGYTYSRYRFKGRKNSLIFFLIIQMVPTMAALTAFYVLAMLLGALDQYWFLTLIYIGGGIPMNTWLMKGY 166
Cdd:COG0395   87 TVLSLLLSSLAAYALARFRFRGRKLLFLLILATLMIPGQVLLIPLYLLFRQLGLLNTYWGLILPYLAFGLPFGIFLLRQF 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 908216747 167 FDTVPRDLDESAKLDGAGHFRIFAQIILPLVRPMIAVQALWAFMGPFGDFLLAKFLLRTPENLTIAVGLQTFIaNPQQQK 246
Cdd:COG0395  167 FRSIPRELEEAARIDGASEFRIFWRIVLPLSKPALATVAIFTFIGAWNDFLWPLILLTSPDLRTLPVGLASFQ-GQYGTD 245

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 908216747 247 VALFAAGAILAALPICLLFFFLQKNFVSGLTAGGTKG 283
Cdd:COG0395  246 WGLLMAAAVIATLPVLILFLFLQRYFVRGLTAGAVKG 282
malG PRK10998
maltose ABC transporter permease MalG;
17-283 3.67e-49

maltose ABC transporter permease MalG;


Pssm-ID: 182891  Cd Length: 296  Bit Score: 164.50  E-value: 3.67e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 908216747  17 FFTYLFLTVLTIIILYPILITASSAFKPGNIAAFTLeWSDSWTLNNFTRLFN-------------ETLYLDWYKNTLIIA 83
Cdd:PRK10998  14 FATHLLLLGFIALIMFPLLMVIAISLREGNFATGSL-IPEQISWEHWKLALGfsvehadgrvtppPFPVLLWLWNSVKVA 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 908216747  84 VVTMIMQVTIVTLAGYTYSRYRFKGRKNSLIFFLIIQMVPTMAALTAFYVLAMLLG------ALDQYWFLTLIYIGGgIP 157
Cdd:PRK10998  93 GITAIGIVALSTTCAYAFARMRFKGKATLLKGMLIFQMFPAVLSLVALYALFDRLGqyipfiGLNTHGGVIFAYLGG-IA 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 908216747 158 MNTWLMKGYFDTVPRDLDESAKLDGAGHFRIFAQIILPLVRPMIAVQALWAFMGPFGDFLLAKFLLRTPENLTIAVGLQT 237
Cdd:PRK10998 172 LHVWTIKGYFETIDSSLEEAAALDGATPWQAFRLVLLPLSVPILAVVFILSFIAAITEVPVASLLLRDVNSYTLAVGMQQ 251

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 908216747 238 FIaNPQQQKVALFAAGAILAALPICLLFFFLQKNFVSGLTAGGTKG 283
Cdd:PRK10998 252 YL-NPQNYLWGDFAAAAVLSAIPITVVFLLAQRWLVGGLTAGGVKG 296
PotC COG1177
ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport ...
 14-268 3.52e-22

ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism];


Pssm-ID: 440790 [Multi-domain]  Cd Length: 262  Bit Score: 92.48  E-value: 3.52e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 908216747  14 LTQFFTYLFLTVLTIIILYPILITASSAFKPGNIAAFtleWSDSWTLNNFTRLFNETLYLDWYKNTLIIAVVTMIMQVTI 93
Cdd:COG1177    4 LGRLLLRLFLALVLLFLYLPILVLVLYSFNDSWFLTF---PPEGFTLRWYAELFSDPRLLDALLNSLLIALLSTLLATVL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 908216747  94 VTLAGYTYSRYRFKGRKNSLIFFLIIQMVPTMAALTAFYVLAMLLGALDQYWFLTLIYIGGGIPMNTWLMKGYFDTVPRD 173
Cdd:COG1177   81 GTPAALALARYRFRGRRLLLALLLLPLVVPGIVLGVALLLLFSALGLSGGLWGLILAHVVFTLPFVVLVVLARLQGFDPS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 908216747 174 LDESAKLDGAGHFRIFAQIILPLVRPMIAVQALWAFMGPFGDFLLAkFLLRTPENLTIAVGLQTFIANPQQQKVAlfAAG 253
Cdd:COG1177  161 LEEAARDLGASPWQTFRRVTLPLIAPGILAGALLAFTLSFDEFVIT-LFLAGPGVTTLPVYIYSMIRRGISPEIN--ALS 237

                        250
                 ....*....|....*
gi 908216747 254 AILAALPICLLFFFL 268
Cdd:COG1177  238 TLLILLSLLLLLLAE 252
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
17-270 4.90e-15

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 74.81  E-value: 4.90e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 908216747  17 FFTYLFLTVLTIIILYPILITASSAFKPGniaaftleWSDSWTLNNFTRLFNETLYLDWYKNTLIIAVVTMIMQVTIVTL 96
Cdd:COG1178  289 LALALCLLLVLLGLLLPLLALLLWSLTKA--------LDDNLTLDNYRFVLLDPSLLRALLNSLLLALLAALLAVLLALL 360

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 908216747  97 AGYTYSRYRFKGRKNSLIFFLIIQMVPTMAALTAFYVLAMLLGALDQY---WFLTLIYIGGGIPMNTWLMKGYFDTVPRD 173
Cdd:COG1178  361 LAYLVRRRRGRLARLLDRLAMLPYAVPGIVLGLGLLLLFNRPLPLLLYgtlAILVLAYVVRFLPFALRSLEAALAQIDPS 440

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 908216747 174 LDESAKLDGAGHFRIFAQIILPLVRPMIAVQALWAFMGPFGDFLLAkFLLRTPENLTIAVGLQTFIANPQQQKVALFAAG 253
Cdd:COG1178  441 LEEAARSLGASPLRTLRRVTLPLLRPGLLAAALLVFVTSMKELSAT-LLLRPPGFETLAVLIYQLASSGRYGEAAALALL 519

                        250
                 ....*....|....*..
gi 908216747 254 AILAALPICLLFFFLQK 270
Cdd:COG1178  520 LVLVSLLPVLLLERLLG 536
potC PRK09500
spermidine/putrescine ABC transporter membrane protein; Reviewed
 14-209 3.41e-14

spermidine/putrescine ABC transporter membrane protein; Reviewed


Pssm-ID: 236542 [Multi-domain]  Cd Length: 256  Bit Score: 70.40  E-value: 3.41e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 908216747  14 LTQFFTYLFLTVLTIIILYPILITASSAFkpgNIAAFTLEWSdSWTLNNFTRLFNETLYLDWYKNTLIIAVVTMIMQVTI 93
Cdd:PRK09500   1 MGRLLRGGFMTLVYAYLYIPIIILIVNSF---NSSRFGINWK-GFTTKWYELLFNNDSLLQAAQHSLTMAVFSATFATLI 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 908216747  94 VTLAGYTYSRYRFKGRK--NSLIFflIIQMVPTMAALTAFYVLAMLLGALDQYWFLTLIYIGGGIPMNTWLMKGYFDTVP 171
Cdd:PRK09500  77 GSLTAVALYRYRFRGKKfvSGMLF--VVMMSPDIVMAISLLVLFMLLGIQLGFWSLLFAHITFCLPFVVVTVYSRLKGFD 154

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 908216747 172 RDLDESAKLDGAGHFRIFAQIILPLVRPMIAVQALWAF 209
Cdd:PRK09500 155 VRMLEAAKDLGASEFTILRKIILPLALPAVAAGWLLSF 192
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 93-276 5.11e-14

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 68.86  E-value: 5.11e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 908216747   93 IVTLAGYTYSRYRFKGRKNSLIFFLIIQMVPTMAALTAFYVLAMLLGALDQYWFLTLIYIGGGIPMNTWLMKGYFDTVPR 172
Cdd:pfam00528   1 GIPLGIIAALRRGRRLDRLLRPLIDLLQALPSFVLAILLVVIAILSILGHGILPAIILALLGWAGYARLIRRAALRSLPS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 908216747  173 DLDESAKLDGAGHFRIFAQIILPLVRPMIAVQALWAFMGPFGDFLLAKFLLRTPenltiavGLQTFIANPQQQK----VA 248
Cdd:pfam00528  81 DLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWP-------GLGLLLIEAILGYdypeIQ 153

                         170       180
                  ....*....|....*....|....*...
gi 908216747  249 LFAAGAILAALPICLLFFFLQKNFVSGL 276
Cdd:pfam00528 154 GPVLAAALILLLLNLLVDILQRLLDPRV 181
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 78-261 5.62e-14

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 68.84  E-value: 5.62e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 908216747  78 NTLIIAVVTMIMQVTIVTLAGYTYSRYRFKGRKNSLIFFLIIQMVPTMAALTAFYVLAMLLGALDQYWFLTL----IYIG 153
Cdd:cd06261    3 NTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILPGLGLpaliLALL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 908216747 154 GGIPMNTWLMKGYFDTVPRDLDESAKLDGAGHFRIFAQIILPLVRPMIAVQALWAFMGPFGDFLLAKFLLrTPENLTIAV 233
Cdd:cd06261   83 LIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLG-GGEAPGPGT 161

                        170       180
                 ....*....|....*....|....*...
gi 908216747 234 GLQTFIANPQQQKVALFAAGAILAALPI 261
Cdd:cd06261  162 GLLLIFAILFPGDLGVAAAVALILLLLS 189
UgpA COG1175
ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];
22-216 3.25e-12

ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism];


Pssm-ID: 440788 [Multi-domain]  Cd Length: 298  Bit Score: 65.54  E-value: 3.25e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 908216747  22 FLTVLTIIILYPILITASSAFKPGNIAAFTLEWSDswtLNNFTRLFNETLYLDWYKNTLIIAVVTMIMQVTIVTLAGYTY 101
Cdd:COG1175   27 ALLLLLVFVLYPLLYTLYLSFTDWNLLGPPPEFVG---LDNYARLFTDPRFWNALGNTLLFTVVSVPLQLVLGLLLALLL 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 908216747 102 SRyRFKGRKNSLIFFLIIQMVPTMAALTAFY--------VLAMLLGAL---DQYWF---------LTLIYIGGGIPMNTW 161
Cdd:COG1175  104 NR-KLRGRGFFRTLFFLPWVISPVVVALIWKwlfnpdygLLNALLGALglePINWLgdpslalpaVIIVTVWKGTGFNML 182

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 908216747 162 LMKGYFDTVPRDLDESAKLDGAGHFRIFAQIILPLVRPMIAVQALWAFMGPFGDF 216
Cdd:COG1175  183 IFLAGLQSIPRELYEAARIDGASPWQRFRRITLPLLRPTILFVLVLSTIGALQVF 237
FbpB COG1178
ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];
21-270 6.11e-12

ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440791 [Multi-domain]  Cd Length: 538  Bit Score: 65.57  E-value: 6.11e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 908216747  21 LFLTVLTIIILYPILITASSAFKPGniaaftlewsdswtLNNFTRLFNETLYLDWYKNTLIIAVVTMIMQVTIVTLAGYT 100
Cdd:COG1178   15 LLALLLALLVLLPLLALLLRAFTDG--------------LANFWALLSDPYLWRALGNTLLLALLVTLLSLLLGVPLAWL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 908216747 101 YSRYRFKGRKNSLIFFLIIQMVPTMA---ALTAFY----VLAMLLGALDQYWFLTLIYIGGGI--------PMNTWLMKG 165
Cdd:COG1178   81 LARTDFPGRRLLRWLLLLPLALPPYVvalAWIALFgpngLLNTLLRALFGLEPPDIYGLGGIIlvlvlfnyPYVYLLLRA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 908216747 166 YFDTVPRDLDESAKLDGAGHFRIFAQIILPLVRPMIAVQALWAFMGPFGDFLLAKFLlrTPENLTIAVGLQTFIANPQQq 245
Cdd:COG1178  161 ALRSIDASLEEAARSLGASPWRAFRRVTLPLLRPAIAAGALLVFLLCLADFGTPLVL--GGGYTTLTTAIYQAWLGDFD- 237

                        250       260
                 ....*....|....*....|....*..
gi 908216747 246 kvalFAAGAILAA--LPICLLFFFLQK 270
Cdd:COG1178  238 ----LGAAAALALvlLLLVLLLLLLER 260
PRK10973 PRK10973
sn-glycerol-3-phosphate ABC transporter permease UgpE;
78-276 8.80e-10

sn-glycerol-3-phosphate ABC transporter permease UgpE;


Pssm-ID: 182875 [Multi-domain]  Cd Length: 281  Bit Score: 58.21  E-value: 8.80e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 908216747  78 NTLIIAVVTMIMQVTIVTLAGYTYSRYRFKGRKNSLIFFLIIQMVPTMAALTAFYVLAMLLGALDQYWFLTLIYIGGGIP 157
Cdd:PRK10973  79 NSFVMAFSITVGKITVSMLSAFAIVWFRFPLRNLFFWMIFITLMLPVEVRIFPTVEVIANLKMLDSYAGLTLPLMASATA 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 908216747 158 mnTWLMKGYFDTVPRDLDESAKLDGAGHFRIFAQIILPLVRPMIAVQALWAFMGPFGDFLLAKFLLRTPENLTIAVGLQT 237
Cdd:PRK10973 159 --TFLFRQFFMTLPDELVEAARIDGASPMRFFWDIVLPLSKTNLAALFVITFIYGWNQYLWPLLIITDVSLGTAVAGIKG 236

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 908216747 238 FIANPQ-QQKVALFAAGAILAALPICLLFFFLQKNFVSGL 276
Cdd:PRK10973 237 MIATGEgTTEWNQVMAAMLLTLIPPVVIVLAMQRAFVRGL 276
PotB COG1176
ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport ...
 5-222 2.47e-08

ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism];


Pssm-ID: 440789 [Multi-domain]  Cd Length: 287  Bit Score: 54.00  E-value: 2.47e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 908216747   5 MKDQRTTKFLTQFFTYLFLTVLTIIILYPILITASSAFKPGNIAAftlEWSDSWTLNNFTRLFNETLYLDWYKNTLIIAV 84
Cdd:COG1176    1 MSAALRRRLRPLLLLLPALLWLLLFFVLPLLLLLVYSFTTRDPYG---GVVPGFTLENYARLFTDPLYLKVLLRTLWIAL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 908216747  85 VTmimqvTIVTLA-GYTYSRY--RFKGRKNSLIFFLIIQ--MVPTMAALTAFYVL----------AMLLGALDQ-----Y 144
Cdd:COG1176   78 LT-----TLICLLlGYPIAYFlaRAPPRWRNLLLLLVILpfWTSFLVRTYAWIVLlgrngllnslLLALGLIDEplrllY 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 908216747 145 W----FLTLIYIGggIPMNTWLMKGYFDTVPRDLDESAKLDGAGHFRIFAQIILPLVRPMIAVQALWAFMGPFGDFLLAK 220
Cdd:COG1176  153 TefavVIGLVYVY--LPFMVLPLYAALEKIDPSLLEAARDLGASPWQTFRRVILPLSLPGIIAGSLLVFIPALGAFVTPA 230


                 ..
gi 908216747 221 FL 222
Cdd:COG1176  231 LL 232
PRK10561 PRK10561
sn-glycerol-3-phosphate ABC transporter permease UgpA;
60-213 5.60e-04

sn-glycerol-3-phosphate ABC transporter permease UgpA;


Pssm-ID: 182550 [Multi-domain]  Cd Length: 280  Bit Score: 40.58  E-value: 5.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 908216747  60 LNNFTRLFNETLYLDWYKNTLI----IAVVTMIMQVTIVTLAGYTYSRYRFKgrknSLIFFLIIQMVPTMAALTAFYV-- 133
Cdd:PRK10561  41 LDNFVALFHDSYYLDSFWTTIKfstlVTVSGLLVSLFFAALVDYVVRGSRFY----QTLMLLPYAVAPAVAAVLWIFLfn 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 908216747 134 -----LAMLLGALDQYW-----------FLTLIYIGGGIPMNTWLMKGYFDTVPRDLDESAKLDGAGHFRIFAQIILPLV 197
Cdd:PRK10561 117 pgrglITHFLAEFGYDWnhaqnsgqamfLVVFASVWKQISYNFLFFFAALQSIPRSLVEAAAIDGAGPIRRFFKLALPLI 196

                        170       180
                 ....*....|....*....|
gi 908216747 198 RP----MIAVQALWAFMGPF 213
Cdd:PRK10561 197 APvsffLLVVNLVYAFFDTF 216
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH