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Conserved domains on  [gi|901899506|gb|AKR57829|]
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lytic transglycosylase [Devosia sp. H5989]

Protein Classification

lytic transglycosylase domain-containing protein( domain architecture ID 11432856)

lytic transglycosylase domain-containing protein similar to lytic transglycosylase which catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 34-154 1.93e-38

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 133.58  E-value: 1.93e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901899506  34 PYGDHIAEASRRFGVPIAWIRAVMRAESAGDPRALSPKGAMGLMQIMPPTWAGLRLRHRLG---ADPYDPHDNIIAGAGY 110
Cdd:COG0741  102 PYLPLIEEAAKKYGVDPALVLALIRQESAFNPNAVSPAGARGLMQLMPATARRLGLKLGLGpspDDLFDPETNIRAGAAY 181

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 901899506 111 IRELFDRYGS--PGWIAAYNAGPGRYEDSLKGR------ALP-AETRAYVAIV 154
Cdd:COG0741  182 LRELLDRFDGdlVLALAAYNAGPGRVRRWLRRNgdrdgeIIPyAETRNYVKKV 234
 
Name Accession Description Interval E-value
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 34-154 1.93e-38

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 133.58  E-value: 1.93e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901899506  34 PYGDHIAEASRRFGVPIAWIRAVMRAESAGDPRALSPKGAMGLMQIMPPTWAGLRLRHRLG---ADPYDPHDNIIAGAGY 110
Cdd:COG0741  102 PYLPLIEEAAKKYGVDPALVLALIRQESAFNPNAVSPAGARGLMQLMPATARRLGLKLGLGpspDDLFDPETNIRAGAAY 181

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 901899506 111 IRELFDRYGS--PGWIAAYNAGPGRYEDSLKGR------ALP-AETRAYVAIV 154
Cdd:COG0741  182 LRELLDRFDGdlVLALAAYNAGPGRVRRWLRRNgdrdgeIIPyAETRNYVKKV 234
LT-like cd00254
lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble ...
 51-154 1.24e-35

lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble membrane-bound LTs in bacteria and LTs in bacteriophage lambda. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381594 [Multi-domain]  Cd Length: 111  Bit Score: 122.32  E-value: 1.24e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901899506  51 AWIRAVMRAESAGDPRALSPKGAMGLMQIMPPTWAGLRLRHrlGADPYDPHDNIIAGAGYIRELFDRYGSPGW--IAAYN 128
Cdd:cd00254    2 ALVLAVIRVESGFNPRAVSPAGARGLMQLMPGTARDLGRRG--VDDLFDPEENIRAGARYLRELLDRFGGDLElaLAAYN 79

                         90       100
                 ....*....|....*....|....*..
gi 901899506 129 AGPGRYEDSLKGRALP-AETRAYVAIV 154
Cdd:cd00254   80 AGPGAVDRWGGGEVPPyKETRNYVQRV 106
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 39-133 4.89e-28

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 102.77  E-value: 4.89e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901899506   39 IAEASRRFGVPIAWIRAVMRAESAGDPRALSPKGAMGLMQIMPPTWAGLRLRHRLGAD-PYDPHDNIIAGAGYIRELFDR 117
Cdd:pfam01464   1 IIKAAQKYGVDPSLLLAIAQQESGFNPKAVSKSGAVGLMQIMPSTAKRLGLRVNPGVDdLFDPEKNIKAGTKYLKELYKQ 80

                          90
                  ....*....|....*...
gi 901899506  118 YGSPGW--IAAYNAGPGR 133
Cdd:pfam01464  81 YGGDLWlaLAAYNAGPGR 98
PRK11619 PRK11619
lytic murein transglycosylase; Provisional
 35-151 1.33e-12

lytic murein transglycosylase; Provisional


Pssm-ID: 183236 [Multi-domain]  Cd Length: 644  Bit Score: 66.62  E-value: 1.33e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901899506  35 YGDHIAEASRRFGVPIAWIRAVMRAESAGDPRALSPKGAMGLMQIMPPT---------WAGLRLRHRLgadpYDPHDNII 105
Cdd:PRK11619 479 WNDEFRRYTSGKGIPQSYAMAIARQESAWNPKARSPVGASGLMQIMPGTathtvkmfsIPGYSSSSQL----LDPETNIN 554

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 901899506 106 AGAGYIRELFDRYGSPGWI--AAYNAGPGRYEDSLK---GR--------ALP-AETRAYV 151
Cdd:PRK11619 555 IGTSYLEYVYQQFGNNRILasAAYNAGPGRVRTWLGnsaGRidavafveSIPfSETRGYV 614
 
Name Accession Description Interval E-value
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 34-154 1.93e-38

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 133.58  E-value: 1.93e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901899506  34 PYGDHIAEASRRFGVPIAWIRAVMRAESAGDPRALSPKGAMGLMQIMPPTWAGLRLRHRLG---ADPYDPHDNIIAGAGY 110
Cdd:COG0741  102 PYLPLIEEAAKKYGVDPALVLALIRQESAFNPNAVSPAGARGLMQLMPATARRLGLKLGLGpspDDLFDPETNIRAGAAY 181

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 901899506 111 IRELFDRYGS--PGWIAAYNAGPGRYEDSLKGR------ALP-AETRAYVAIV 154
Cdd:COG0741  182 LRELLDRFDGdlVLALAAYNAGPGRVRRWLRRNgdrdgeIIPyAETRNYVKKV 234
LT-like cd00254
lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble ...
 51-154 1.24e-35

lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble membrane-bound LTs in bacteria and LTs in bacteriophage lambda. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381594 [Multi-domain]  Cd Length: 111  Bit Score: 122.32  E-value: 1.24e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901899506  51 AWIRAVMRAESAGDPRALSPKGAMGLMQIMPPTWAGLRLRHrlGADPYDPHDNIIAGAGYIRELFDRYGSPGW--IAAYN 128
Cdd:cd00254    2 ALVLAVIRVESGFNPRAVSPAGARGLMQLMPGTARDLGRRG--VDDLFDPEENIRAGARYLRELLDRFGGDLElaLAAYN 79

                         90       100
                 ....*....|....*....|....*..
gi 901899506 129 AGPGRYEDSLKGRALP-AETRAYVAIV 154
Cdd:cd00254   80 AGPGAVDRWGGGEVPPyKETRNYVQRV 106
Slt70-like cd13401
70kDa soluble lytic transglycosylase (Slt70) and similar proteins; Catalytic domain of the ...
 34-151 1.57e-30

70kDa soluble lytic transglycosylase (Slt70) and similar proteins; Catalytic domain of the 70kda soluble lytic transglycosylase (LT)-like proteins, which also have an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381604 [Multi-domain]  Cd Length: 152  Bit Score: 110.26  E-value: 1.57e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901899506  34 PYGDHIAEASRRFGVPIAWIRAVMRAESAGDPRALSPKGAMGLMQIMPPT----WAGLRLRHRLGADPYDPHDNIIAGAG 109
Cdd:cd13401    5 PYRDLVERAAKKNGLDPALVYAIIRQESAFDPDAVSPAGALGLMQLMPATakdvAKKLGLPYYSPRDLFDPEYNIRLGSA 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 901899506 110 YIRELFDRY-GSPGW-IAAYNAGPGRYEDSLKGR----------ALP-AETRAYV 151
Cdd:cd13401   85 YLAELLDRFdGNPVLaLAAYNAGPGRVRRWLKRRgdldpdlwieTIPfSETRNYV 139
LT_Slt70-like cd16896
uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized ...
 34-154 8.05e-30

uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized lytic transglycosylase (LT) with a conserved sequence pattern suggesting similarity to the Slt70, a 70kda soluble lytic transglycosylase which also has an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381617 [Multi-domain]  Cd Length: 146  Bit Score: 108.37  E-value: 8.05e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901899506  34 PYGDHIAEASRRFGVPIAWIRAVMRAESAGDPRALSPKGAMGLMQIMPPT--WAGLRLRHRLGA--DPYDPHDNIIAGAG 109
Cdd:cd16896    3 KYREYIEKYAKEYGVDPLLVAAVIKVESNFNPNAVSSKGAIGLMQIMPETaeWIAEKLGLEDFSedDLYDPETNIRLGTW 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 901899506 110 YIRELFDRYGS--PGWIAAYNAGPGR-------YEDSLKGRAL----PAETRAYVAIV 154
Cdd:cd16896   83 YLSYLLKEFDGnlVLALAAYNAGPGNvdkwlkdGGWSGDGKTLdqipFPETRHYVKKV 140
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 39-133 4.89e-28

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 102.77  E-value: 4.89e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901899506   39 IAEASRRFGVPIAWIRAVMRAESAGDPRALSPKGAMGLMQIMPPTWAGLRLRHRLGAD-PYDPHDNIIAGAGYIRELFDR 117
Cdd:pfam01464   1 IIKAAQKYGVDPSLLLAIAQQESGFNPKAVSKSGAVGLMQIMPSTAKRLGLRVNPGVDdLFDPEKNIKAGTKYLKELYKQ 80

                          90
                  ....*....|....*...
gi 901899506  118 YGSPGW--IAAYNAGPGR 133
Cdd:pfam01464  81 YGGDLWlaLAAYNAGPGR 98
LT_MltC_MltE cd16893
membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and ...
 39-154 1.30e-22

membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and MltE are periplasmic, outer membrane attached lytic transglycosylases (LTs), which cleave beta-1,4-glycosidic bonds joining N-acetylmuramic acid and N-acetylglucosamine in the cell wall peptidoglycan, yielding 1,6-anhydromuropeptides. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda


Pssm-ID: 381614 [Multi-domain]  Cd Length: 162  Bit Score: 90.31  E-value: 1.30e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901899506  39 IAEASRRFGVPIAWIRAVMRAESAGDPRALSPKGAMGLMQIMPPTwAGL---RLRHRLGADP-----YDPHDNIIAGAGY 110
Cdd:cd16893    3 VEKYAKKYGVDPALILAIIETESSFNPYAVSHSPAYGLMQIVPST-AGRdvyRLLGGKGGLPsksylFDPENNIDIGTAY 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 901899506 111 IRELFDRYGSP---------GWIAAYNAGPG---RYEDSLKGRALP--------------------AETRAYVAIV 154
Cdd:cd16893   82 LHILQNRYLKGiknpksreyCAIAAYNGGAGnvlRTFSSDRKKAISkinrlspdevyqhltkklpaAETRNYLKKV 157
MltF COG4623
Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, ...
 33-151 4.71e-21

Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, Signal transduction mechanisms];


Pssm-ID: 443662 [Multi-domain]  Cd Length: 421  Bit Score: 90.51  E-value: 4.71e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901899506  33 DPYGDHIAEASRRFGVPIAWIRAVMRAESAGDPRALSPKGAMGLMQIMPPT--WAGLrlrhrlgADPYDPHDNIIAGAGY 110
Cdd:COG4623  262 PPYDPLFEKYAEEYGLDWRLLAALAYQESHWNPRARSPTGARGLMQLMPATakELGV-------DDRLDPEQSIRAGAKY 334

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 901899506 111 IRELFDRYGSPG------W--IAAYNAGPGR--------------------YEDSLK-----GRALPAETRAYV 151
Cdd:COG4623  335 LRWLYDRFPEAIdepdrwWfaLAAYNAGPGHvqdarrlakkqgldpdrwfdVEKSQPkyydtGYARGRETVNYV 408
MLTF-like cd13403
membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins; This subfamily ...
 41-136 5.05e-17

membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins; This subfamily includes membrane-bound lytic murein transglycosylase F (MltF, murein lyase F) that degrades murein glycan strands. It is responsible for catalyzing the release of 1,6-anhydromuropeptides from peptidoglycan. Lytic transglycosylase catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do goose-type lysozymes. However, in addition, it also makes a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381606 [Multi-domain]  Cd Length: 161  Bit Score: 75.26  E-value: 5.05e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901899506  41 EASRRFGVPIAWIRAVMRAESAGDPRALSPKGAMGLMQIMPPTWAglrlrhRLG-ADPYDPHDNIIAGAGYIRELFDRYg 119
Cdd:cd13403    3 KYAEKYGFDWRLLAAQAYQESRFNPNARSPAGARGLMQLMPSTAR------ELGvNDRLDPEQNIHAGAKYLRYLRDRF- 75

                         90       100
                 ....*....|....*....|....*.
gi 901899506 120 SPG-------WI--AAYNAGPGRYED 136
Cdd:cd13403   76 PPDidepdrlKFalAAYNAGPGHVRD 101
MltD-like cd16894
Membrane-bound lytic murein transglycosylase D and similar proteins; Lytic transglycosylases ...
 44-152 2.18e-15

Membrane-bound lytic murein transglycosylase D and similar proteins; Lytic transglycosylases (LT) catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc). Membrane-bound lytic murein transglycosylase D protein (MltD) family members may have one or more small LysM domains, which may contribute to peptidoglycan binding. Unlike the similar "goose-type" lysozymes, LTs also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381615 [Multi-domain]  Cd Length: 129  Bit Score: 70.24  E-value: 2.18e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901899506  44 RRFGVPIAWIRAVMrAESAGDPRALSPKGAMGLMQIMPPTWAGLRLRHRLGADP-YDPHDNIIAGAGYIRELFDRYGSpg 122
Cdd:cd16894    2 LKEGLPEELKYLAL-VESGFNPDAVSSAGAAGLWQFMPATAREYGLRVDSWVDErRDPEKSTRAAARYLKDLYKRFGD-- 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 901899506 123 W---IAAYNAGPGR-----------YEDSLKGRALPAETRAYVA 152
Cdd:cd16894   79 WllaLAAYNAGEGRvrraikragtdKWEDYYRLYLPAETRRYVP 122
PRK11619 PRK11619
lytic murein transglycosylase; Provisional
 35-151 1.33e-12

lytic murein transglycosylase; Provisional


Pssm-ID: 183236 [Multi-domain]  Cd Length: 644  Bit Score: 66.62  E-value: 1.33e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901899506  35 YGDHIAEASRRFGVPIAWIRAVMRAESAGDPRALSPKGAMGLMQIMPPT---------WAGLRLRHRLgadpYDPHDNII 105
Cdd:PRK11619 479 WNDEFRRYTSGKGIPQSYAMAIARQESAWNPKARSPVGASGLMQIMPGTathtvkmfsIPGYSSSSQL----LDPETNIN 554

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 901899506 106 AGAGYIRELFDRYGSPGWI--AAYNAGPGRYEDSLK---GR--------ALP-AETRAYV 151
Cdd:PRK11619 555 IGTSYLEYVYQQFGNNRILasAAYNAGPGRVRTWLGnsaGRidavafveSIPfSETRGYV 614
Slt35-like cd13399
Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic ...
 46-134 2.18e-12

Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic transglycosylase Slt35 and Pseudomonas aeruginosa Sltb1. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381602 [Multi-domain]  Cd Length: 108  Bit Score: 61.56  E-value: 2.18e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901899506  46 FGVPIAWIRAVMRAESAGDPRAL-SPKGAMGLMQIMPPTWA--GLRLRHRLGADPYDPHDNIIAGAGYIRELFDRYGSPG 122
Cdd:cd13399    1 YGVPPGILAAILGVESGFGPNAGgSPAGAQGIAQFMPSTWKayGVDGNGDGKADPFNPEDAIASAANYLCRHGWDLNAFL 80

                         90
                 ....*....|....*...
gi 901899506 123 W------IAAYNAGPGRY 134
Cdd:cd13399   81 GednflaLAAYNAGPGAY 98
mltC PRK11671
membrane-bound lytic murein transglycosylase MltC;
39-142 8.16e-12

membrane-bound lytic murein transglycosylase MltC;


Pssm-ID: 183271 [Multi-domain]  Cd Length: 359  Bit Score: 63.92  E-value: 8.16e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901899506  39 IAEASRRFGVPIAWIRAVMRAESAGDPRALSPKGAMGLMQIMPPTwAG---LRLRHRLGaDP-----YDPHDNIIAGAGY 110
Cdd:PRK11671 196 VRKASRKYGVDESLILAIMQTESSFNPYAVSRSDALGLMQVVQHT-AGkdvFRMKGKSG-QPsrsylFDPANNIDTGTAY 273

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 901899506 111 IRELFDRY----GSP-----GWIAAYNAGPG---RYEDSLKGRA 142
Cdd:PRK11671 274 LAILQNVYlggiTNPtsrryAVITAYNGGAGsvlRVFSNDKIQA 317
LT_IagB-like cd13400
Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like ...
 46-136 6.88e-10

Escherichia coli invasion protein IagB and similar proteins; Lytic transglycosylase-like protein, similar to Escherichia coli invasion protein IagB. IagB is encoded within a pathogenicity island in Salmonella enterica and has been shown to degrade polymeric peptidoglycan. IagB-like invasion proteins are implicated in the invasion of eukaryotic host cells by bacteria. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Members of this family resemble the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381603 [Multi-domain]  Cd Length: 109  Bit Score: 54.84  E-value: 6.88e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901899506  46 FGVPIAWIRAVMRAESAGDPRALSPKG----AMGLMQI----MPPTWAGLRLRHRLGadpYDPHDNIIAGAGYIRELFDR 117
Cdd:cd13400    1 YGVPPRLLRAIAKVESGFNPNAINRNKngsyDIGLMQInsiwLPELARYGITREELL---NDPCTNIYVGAWILARNIKR 77

                         90       100
                 ....*....|....*....|.
gi 901899506 118 YGSpGW--IAAYNAGPGRYED 136
Cdd:cd13400   78 YGN-TWkaVGAYNSGTPKKND 97
LT_TF-like cd13402
lytic transglycosylase-like domain of tail fiber-like proteins and similar domains; These tail ...
 51-136 1.62e-08

lytic transglycosylase-like domain of tail fiber-like proteins and similar domains; These tail fiber-like proteins are multi-domain proteins that include a lytic transglycosylase (LT) domain. Members of the LT family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, and the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL). LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381605 [Multi-domain]  Cd Length: 117  Bit Score: 51.04  E-value: 1.62e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901899506  51 AWIRAVMRaESAGDPRAL------SPKG--AMGLMQIMPPTWAGLRLrhRLGADPYDPHDNIIAGAGYIRelfDRYGSPG 122
Cdd:cd13402    3 ALLRQIQT-ESGGNPNAInnwdsnAKAGhpSKGLMQVIPPTFAAYAP--PGHGNILNPLDNILAAINYAK---ARYGSGF 76

                         90
                 ....*....|....
gi 901899506 123 WIAAYNaGPGRYED 136
Cdd:cd13402   77 ALAAGG-GGGGYAN 89
PHA00658 PHA00658
putative lysin
 38-235 5.59e-08

putative lysin


Pssm-ID: 106967 [Multi-domain]  Cd Length: 720  Bit Score: 52.90  E-value: 5.59e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901899506  38 HIAEASRRFGVPIAWIRAVMRAESAGDPRAlSPKGAMGLMQIMPPTWAGLRlrhRLGADPYDPHD-------NIIAGAGY 110
Cdd:PHA00658 296 QVSDGERAFNIAVGTESGGRQFGADGKPLT-SPKGAVGIAQVMPDTAPEAA---KLAGLPWDENRyrndaayNRALGMAY 371

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901899506 111 IRELFDRYGS--PGWIAAYNAGPGRYEDSLKGRA-------LPAETRAYVAIVAPSVTSGDATWPIVAAAADALAWTRAP 181
Cdd:PHA00658 372 FQKQLRDFGGdlPKAYAAYNAGPGALQSALKDAKdgnwlalLPKETQDYVVKNMQAYNAGQGRPARPTLADIEAQLQNDP 451

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 901899506 182 LFIAQAERISIpVPVPAERASDAAMTTSSVRDVSAIEP------QSGGLF--VPRSGQRNAP 235
Cdd:PHA00658 452 RLAGNPERLKI-ARVEAERQFNMQTAALKQRDDEAVATalrglyENGGRFseLPVSIRANIP 512
SLT COG3953
SLT domain protein [Mobilome: prophages, transposons];
31-121 7.12e-08

SLT domain protein [Mobilome: prophages, transposons];


Pssm-ID: 443153 [Multi-domain]  Cd Length: 325  Bit Score: 52.02  E-value: 7.12e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901899506  31 PRDPYGDHIAEASRRFGVPIAWIRAVMR---AESAGDPRAL------SPKG--AMGLMQIMPPTWAGLRLR-HrlgADPY 98
Cdd:COG3953  211 AGGWGIDIRQAAALGVPVSEAWVDGILRiiqHESGGNPNAInlwdsnAAAGtpSKGLMQVIPPTFNAYKLPgH---GNIY 287

                         90       100
                 ....*....|....*....|...
gi 901899506  99 DPHDNIIAGAGYIRelfDRYGSP 121
Cdd:COG3953  288 NPVDNILAGINYAK---SRYGSS 307
Lyz-like cd00442
lysozyme-like domains; This family contains several members, including soluble lytic ...
 55-110 7.72e-06

lysozyme-like domains; This family contains several members, including soluble lytic transglycosylases (SLT), goose egg-white lysozymes (GEWL), hen egg-white lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, chitosanases, and pesticin. Typical members are involved in the hydrolysis of beta-1,4- linked polysaccharides.


Pssm-ID: 381596 [Multi-domain]  Cd Length: 59  Bit Score: 42.40  E-value: 7.72e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 901899506  55 AVMRAESAGDP--RALSPKGAMGLMQIMPPTWAGLRLrhRLGADPYDPHDNIIAGAGY 110
Cdd:cd00442    4 AIIGQESGGNKpaNAGSGSGAAGLFQFMPGTWKAYGK--NSSSDLNDPEASIEAAAKY 59
PHA00368 PHA00368
internal virion protein D
 29-133 1.69e-05

internal virion protein D


Pssm-ID: 222785 [Multi-domain]  Cd Length: 1315  Bit Score: 45.54  E-value: 1.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901899506   29 PSPRDPYGDHIAEASRRFGVPIAWIRAVMRAESAGDPRALSPKGAMGLMQIMPPTWAGLRLRHRlGADPYDPHDNIIAGA 108
Cdd:PHA00368    5 KNKPSEYDGLFQKAADAHGVSYDLLRKVGWDESRFNPTAKSPTGPKGLMQFTKATAKALGLIVD-DDDRLDPELAIDAGA 83

                          90       100
                  ....*....|....*....|....*..
gi 901899506  109 GYIRELFDRY-GSPGWIA-AYNAGPGR 133
Cdd:PHA00368   84 RYLADLVGKYdGDELKAAlAYNQGEGR 110
PRK10859 PRK10859
membrane-bound lytic murein transglycosylase MltF;
55-136 4.09e-05

membrane-bound lytic murein transglycosylase MltF;


Pssm-ID: 236778 [Multi-domain]  Cd Length: 482  Bit Score: 44.09  E-value: 4.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901899506  55 AVMRAESAGDPRALSPKGAMGLMQIMPPTWAGLRLRHRLgadpyDPHDNIIAGAGYIRELFDRYgsPGWI---------- 124
Cdd:PRK10859 308 AIAYQESHWNPQATSPTGVRGLMMLTRNTAQSMGVTDRL-----DPEQSIRGGARYLQDLMERL--PESIpeperiwfal 380

                         90
                 ....*....|..
gi 901899506 125 AAYNAGPGRYED 136
Cdd:PRK10859 381 AAYNIGYGHMLD 392
mltD PRK10783
membrane-bound lytic murein transglycosylase D; Provisional
 60-151 6.51e-05

membrane-bound lytic murein transglycosylase D; Provisional


Pssm-ID: 182727 [Multi-domain]  Cd Length: 456  Bit Score: 43.18  E-value: 6.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901899506  60 ESAGDPRALSPKGAMGLMQIMPPTWAGLRLRHRlgaDPYDPHDNIIAGAG-------YIRELFDRygspGW---IAAYNA 129
Cdd:PRK10783 128 ESAFDPHATSGANAAGIWQIIPSTGRNYGLKQT---RWYDARRDVVASTTaaldmmqRLNKMFDG----DWlltVAAYNS 200

                         90       100       110
                 ....*....|....*....|....*....|....
gi 901899506 130 GPGRYEDSLK-----GR-------ALPAETRAYV 151
Cdd:PRK10783 201 GEGRVMKAIKankakGKptdfwslSLPRETKIYV 234
emtA PRK15470
membrane-bound lytic murein transglycosylase EmtA;
41-111 2.30e-04

membrane-bound lytic murein transglycosylase EmtA;


Pssm-ID: 185367 [Multi-domain]  Cd Length: 203  Bit Score: 41.10  E-value: 2.30e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 901899506  41 EASRRFGVPIAWIRAVMRAESAGDPRALSPKGAMGLMQIMPPTwAGLRLRHRLG-------ADPYDPHDNIIAGAGYI 111
Cdd:PRK15470  45 KAGAAWGVDPQLITAIIAIESGGNPNAVSKSNAIGLMQLKAST-SGRDVYRRMGwsgepttSELKNPERNISMGAAYL 121
GEWL cd01021
Goose egg-white lysozyme; Eukaryotic goose-type or G-type lysozyme (goose egg-white lysozyme; ...
 34-133 2.44e-04

Goose egg-white lysozyme; Eukaryotic goose-type or G-type lysozyme (goose egg-white lysozyme; GEWL) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc). Mammals have two lysozymes. This family corresponds to human and mouse lysozyme G-like protein 2.


Pssm-ID: 381601 [Multi-domain]  Cd Length: 174  Bit Score: 40.66  E-value: 2.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 901899506  34 PYGDHIAEASRRFGVPIAWIRAVMRAES-AGdpRALSPKG------AMGLMQImpptwaglRLRHRLGADPYDPHDNIIA 106
Cdd:cd01021   36 KYKDCIKQVGKKLCIDPALIAAIISRESrAG--AALDKNGwgdhgnGFGLMQV--------DKRYHPPKGAWDSEEHIEQ 105

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 901899506 107 GAG----YIRELFDRYgsPGW---------IAAYNAGPGR 133
Cdd:cd01021  106 ATGilidFIKTVQRKH--PSWspeqqlkggIAAYNAGVGN 143
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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