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Conserved domains on  [gi|899764075|gb|AKR38206|]
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Protein YhgE [Bacillus thuringiensis serovar indiana]

Protein Classification

YhgE/Pip domain-containing protein( domain architecture ID 11445492)

YhgE/Pip (phage infection protein) domain-containing protein similar to the membrane protein EsaA of the Staphylococcus aureus ESS/Type VII secretion system, Bacillus subtilis ESX secretion system protein YueB, and uncharacterized protein YhgE

Gene Ontology:  GO:0016020

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
pip_yhgE_Nterm TIGR03061
YhgE/Pip N-terminal domain; This family contains the N-terminal domain of a family of multiple ...
 9-172 4.69e-83

YhgE/Pip N-terminal domain; This family contains the N-terminal domain of a family of multiple membrane-spanning proteins of Gram-positive bacteria. One member was shown to be a host protein essential for phage infection, so many members of this family are called "phage infection protein". A separate model, TIGR03062, represents the conserved C-terminal domain. The domains are separated by regions highly variable in both length and sequence, often containing extended heptad repeats as described in model TIGR03057.


:

Pssm-ID: 274413 [Multi-domain]  Cd Length: 164  Bit Score: 259.06  E-value: 4.69e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 899764075    9 KDWKAMWHHKHGRIALIFLLIVPLIYSGFFLAGYWDPYGKLDKLPVAVVNLDKGAAMDEKTIHVGDDFVKNLKENKELAF 88
Cdd:TIGR03061   1 SELKRLRKNKLLRIALIAIMLIPLLYGGLFLWAFWDPYGNLDNLPVAVVNEDKGATYDGKTLNAGDDLVKELKKNDDLDW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 899764075   89 HFVSEKNADEGLKEDKYYMVVTIPEDFSKKVSTLMNEKPEPAKLQYKVNPGKNFVAAQIGTTAVENMKTKISNSITKSYT 168
Cdd:TIGR03061  81 HFVSAKEAEKGLADGKYYMVITIPEDFSENATSLLDDQPKKAQLIYKTNDANNYIASQIAESAAEKVKTSVSKSITETYA 160


                  ....
gi 899764075  169 EGVF 172
Cdd:TIGR03061 161 ETIF 164
pip_yhgE_Cterm TIGR03062
YhgE/Pip C-terminal domain; This family contains the C-terminal domain of a family of multiple ...
 454-658 7.23e-74

YhgE/Pip C-terminal domain; This family contains the C-terminal domain of a family of multiple membrane-spanning proteins of Gram-positive bacteria. One member was shown to be a host protein essential for phage infection, so many members of this family are called "phage infection protein". A separate model, TIGR03061, represents the conserved N-terminal domain. The domains are separated by regions highly variable in both length and sequence, often containing extended heptad repeats as described in model TIGR03057.


:

Pssm-ID: 274414 [Multi-domain]  Cd Length: 208  Bit Score: 236.70  E-value: 7.23e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 899764075  454 TMFSEPVQLVKSTVSDVPNYGSGIAPYFLSLAFYVGGIMASNILPLGRRQNMKVSGTVH--FINKLGLVYLIGLIQALLV 531
Cdd:TIGR03062   2 KMVAEPVKLKHSDYDDVPNYGTGLAPYFLSLALFVGALVLNLIFPPLSRRALPKSARSWriALAKLLPGGLIGVIQAIIL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 899764075  532 DVVVLGVMKLEVASVPLFVLSSIVISFTFMTFILMLVTVFGLVGKFLAVTLLVLQLATSGGTFPGELNIAVLSKIGQFLP 611
Cdd:TIGR03062  82 YGVLILALGLDPAHPPATFGFAILTSLTFMAIIQFLVALFGSVGRFLALVLLVLQLGSSGGTFPIELLPAFFQAIHPFLP 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 899764075  612 MSHSLRGLQDVISLGDWSQLQMQILILLCYLVVAGGIAWITSHIQHR 658
Cdd:TIGR03062 162 MTYSVNGLRQLISGGDDSTLWQAVAVLLLILVIFLALSLLSARRKRR 208
xxxLxxG_by_4 TIGR03057
X-X-X-Leu-X-X-Gly heptad repeats; This model represents a 28-column alignment, comprising four ...
 203-229 4.53e-03

X-X-X-Leu-X-X-Gly heptad repeats; This model represents a 28-column alignment, comprising four tandem sets of seven residues each, in which the fourth residue tends to be Leu and the seventh tends to be Gly in each set. This heptad periodicity, corresponding to two turns of an alpha helix, suggests alpha-helical structure; in many proteins this 28-region model hits many times in tandem. Arrangement of these sequences on a helical wheel would show a strict alternation of Leu and Gly residues on one side of the helix, that is, an extremely bulky side chain alternating with the virtual absence of one. This suggests an extended zippering of one alpha helix to another, analogous to the shorter leucine zippers found in many dimerizing transcription factors. Proteins in which these heptad repeats occur often have higher order repeats of a unit comprised of several heptads.


:

Pssm-ID: 274412  Cd Length: 28  Bit Score: 35.00  E-value: 4.53e-03
                          10        20
                  ....*....|....*....|....*..
gi 899764075  203 ANQLANGIDRLSDGTSKLKEGSDKLAS 229
Cdd:TIGR03057   1 SGQLADGAGQLASGAGQLASGANQLAD 27
Mtu_fam_mce super family cl36794
virulence factor Mce family protein; Members of this paralogous family are found as six tandem ...
 319-431 5.44e-03

virulence factor Mce family protein; Members of this paralogous family are found as six tandem homologous proteins in the same orientation per cassette, in four separate cassettes in Mycobacterium tuberculosis. The six members of each cassette represent six subfamilies. One subfamily includes the protein mce (mycobacterial cell entry), a virulence protein required for invasion of non-phagocytic cells. [Cellular processes, Pathogenesis]


The actual alignment was detected with superfamily member TIGR00996:

Pssm-ID: 273384 [Multi-domain]  Cd Length: 291  Bit Score: 39.19  E-value: 5.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 899764075  319 KIVATSNGLAKATSTLNNSQQQLTQ---GAKKLTDGQHKIEEGMNTFGVKLNEATAGTKK----IADGASNLaDGFTKWG 391
Cdd:TIGR00996 168 QLRNLLDGLAQLTAALNERDGDIGElirNLNRVLDVLADRSDQLDRLLDNLPTLIATLADrsdaLDDALAAL-SAASAQV 246

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 899764075  392 NGF-----TSLQEGVNQLASGGTELNNGASKLTNGLVKLDDGAKE 431
Cdd:TIGR00996 247 RDLlaenrPNLGQALANLAPVLTLLVDYSPELEQLLHLLPTYAAN 291
 
Name Accession Description Interval E-value
pip_yhgE_Nterm TIGR03061
YhgE/Pip N-terminal domain; This family contains the N-terminal domain of a family of multiple ...
 9-172 4.69e-83

YhgE/Pip N-terminal domain; This family contains the N-terminal domain of a family of multiple membrane-spanning proteins of Gram-positive bacteria. One member was shown to be a host protein essential for phage infection, so many members of this family are called "phage infection protein". A separate model, TIGR03062, represents the conserved C-terminal domain. The domains are separated by regions highly variable in both length and sequence, often containing extended heptad repeats as described in model TIGR03057.


Pssm-ID: 274413 [Multi-domain]  Cd Length: 164  Bit Score: 259.06  E-value: 4.69e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 899764075    9 KDWKAMWHHKHGRIALIFLLIVPLIYSGFFLAGYWDPYGKLDKLPVAVVNLDKGAAMDEKTIHVGDDFVKNLKENKELAF 88
Cdd:TIGR03061   1 SELKRLRKNKLLRIALIAIMLIPLLYGGLFLWAFWDPYGNLDNLPVAVVNEDKGATYDGKTLNAGDDLVKELKKNDDLDW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 899764075   89 HFVSEKNADEGLKEDKYYMVVTIPEDFSKKVSTLMNEKPEPAKLQYKVNPGKNFVAAQIGTTAVENMKTKISNSITKSYT 168
Cdd:TIGR03061  81 HFVSAKEAEKGLADGKYYMVITIPEDFSENATSLLDDQPKKAQLIYKTNDANNYIASQIAESAAEKVKTSVSKSITETYA 160


                  ....
gi 899764075  169 EGVF 172
Cdd:TIGR03061 161 ETIF 164
pip_yhgE_Cterm TIGR03062
YhgE/Pip C-terminal domain; This family contains the C-terminal domain of a family of multiple ...
 454-658 7.23e-74

YhgE/Pip C-terminal domain; This family contains the C-terminal domain of a family of multiple membrane-spanning proteins of Gram-positive bacteria. One member was shown to be a host protein essential for phage infection, so many members of this family are called "phage infection protein". A separate model, TIGR03061, represents the conserved N-terminal domain. The domains are separated by regions highly variable in both length and sequence, often containing extended heptad repeats as described in model TIGR03057.


Pssm-ID: 274414 [Multi-domain]  Cd Length: 208  Bit Score: 236.70  E-value: 7.23e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 899764075  454 TMFSEPVQLVKSTVSDVPNYGSGIAPYFLSLAFYVGGIMASNILPLGRRQNMKVSGTVH--FINKLGLVYLIGLIQALLV 531
Cdd:TIGR03062   2 KMVAEPVKLKHSDYDDVPNYGTGLAPYFLSLALFVGALVLNLIFPPLSRRALPKSARSWriALAKLLPGGLIGVIQAIIL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 899764075  532 DVVVLGVMKLEVASVPLFVLSSIVISFTFMTFILMLVTVFGLVGKFLAVTLLVLQLATSGGTFPGELNIAVLSKIGQFLP 611
Cdd:TIGR03062  82 YGVLILALGLDPAHPPATFGFAILTSLTFMAIIQFLVALFGSVGRFLALVLLVLQLGSSGGTFPIELLPAFFQAIHPFLP 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 899764075  612 MSHSLRGLQDVISLGDWSQLQMQILILLCYLVVAGGIAWITSHIQHR 658
Cdd:TIGR03062 162 MTYSVNGLRQLISGGDDSTLWQAVAVLLLILVIFLALSLLSARRKRR 208
YhgE COG1511
Uncharacterized membrane protein YhgE, phage infection protein (PIP) family [Function unknown]; ...
 7-171 4.76e-70

Uncharacterized membrane protein YhgE, phage infection protein (PIP) family [Function unknown];


Pssm-ID: 441120  Cd Length: 225  Bit Score: 227.13  E-value: 4.76e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 899764075   7 IFKDWKAMWHHKHGRIALIFLLIVPLIYSGFFLAGYWDPYGKLDKLPVAVVNLDKGAAMDEKTIHVGDDFVKNLKENKEL 86
Cdd:COG1511    1 FKRELKRLFKNKLALIALIALILVPLLYAGLYLWAFWDPYGNLDNLPVAVVNEDKGATVDGKTVNLGDELVDELKDNDSF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 899764075  87 AFHFVSEKNADEGLKEDKYYMVVTIPEDFSKKVSTLMNEKPEPAKLQYKVNPGKNFVAAQIGTTAVENMKTKISNSITKS 166
Cdd:COG1511   81 DWQFVSEEEAEKGLKDGKYYAVIVIPEDFSANLASLLSDDPEKATITYYTNEANNYLASKITDTAATTVVDQVNSQVTET 160


                 ....*
gi 899764075 167 YTEGV 171
Cdd:COG1511  161 YAETV 165
YhgE COG1511
Uncharacterized membrane protein YhgE, phage infection protein (PIP) family [Function unknown]; ...
 423-504 2.59e-10

Uncharacterized membrane protein YhgE, phage infection protein (PIP) family [Function unknown];


Pssm-ID: 441120  Cd Length: 225  Bit Score: 60.73  E-value: 2.59e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 899764075 423 VKLDDGAKELSTKLGE-GAEKIADVRNDDARNTMFS--EPVQLVKSTVSDVPNYGSGIAPYFLSLAFYVGGIMASNILPL 499
Cdd:COG1511  128 YYTNEANNYLASKITDtAATTVVDQVNSQVTETYAEtvSPVALKTEALNPVPNYGSGLAPFFLSLALWVGALLLFLLLRP 207


                 ....*
gi 899764075 500 GRRQN 504
Cdd:COG1511  208 LVDRA 212
ABC2_membrane_3 pfam12698
ABC-2 family transporter protein; This family is related to the ABC-2 membrane transporter ...
 24-166 4.30e-10

ABC-2 family transporter protein; This family is related to the ABC-2 membrane transporter family pfam01061.


Pssm-ID: 463674 [Multi-domain]  Cd Length: 345  Bit Score: 61.64  E-value: 4.30e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 899764075   24 LIFLLIVPLIYSGFFLAGYWDPYGKLDKLPVAVVNLDKGAAMDEktihvgddFVKNLKENKE--LAFHFVSEKNADEGLK 101
Cdd:pfam12698   4 LIITLLLPILLILLLGLIFSNAVNDPEELPVAVVDEDNSSLSRQ--------LVRALEASPTvnLVQYVDSEEEAKEALK 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 899764075  102 EDKYYMVVTIPEDFSKKVstlmnEKPEPAKLQYKVNpGKNFVAAQIGTTAVENMKTKISNSITKS 166
Cdd:pfam12698  76 NGKIDGLLVIPKGFSKDL-----LKGESATVTVYIN-SSNLLVSKLILNALQSLLQQLNASALVL 134
ABC2_membrane_3 pfam12698
ABC-2 family transporter protein; This family is related to the ABC-2 membrane transporter ...
 468-651 3.88e-07

ABC-2 family transporter protein; This family is related to the ABC-2 membrane transporter family pfam01061.


Pssm-ID: 463674 [Multi-domain]  Cd Length: 345  Bit Score: 52.78  E-value: 3.88e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 899764075  468 SDVPNYGSGIAPYFLSLAFYVGGIMASNIL------PLGRRQN-MKVSGTVHFINKLGLVYLIGLIQALLVDVVVLGVMk 540
Cdd:pfam12698 154 NPQSGYAYYLVGLILMIIILIGAAIIAVSIveekesRIKERLLvSGVSPLQYWLGKILGDFLVGLLQLLIILLLLFGIG- 232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 899764075  541 LEVASVPLFVLSSIVISFTFMTFILMLVTVFG--LVGKFLAVTLLVLQLATSGGTFPGELNIAVLSKIGQFLPMSHSLRG 618
Cdd:pfam12698 233 IPFGNLGLLLLLFLLYGLAYIALGYLLGSLFKnsEDAQSIIGIVILLLSGFFGGLFPLEDPPSFLQWIFSIIPFFSPIDG 312

                         170       180       190
                  ....*....|....*....|....*....|...
gi 899764075  619 LQDVISLGDWSQLQMQILILLCYLVVAGGIAWI 651
Cdd:pfam12698 313 LLRLIYGDSLWEIAPSLIILLLFAVVLLLLALL 345
xxxLxxG_by_4 TIGR03057
X-X-X-Leu-X-X-Gly heptad repeats; This model represents a 28-column alignment, comprising four ...
 203-229 4.53e-03

X-X-X-Leu-X-X-Gly heptad repeats; This model represents a 28-column alignment, comprising four tandem sets of seven residues each, in which the fourth residue tends to be Leu and the seventh tends to be Gly in each set. This heptad periodicity, corresponding to two turns of an alpha helix, suggests alpha-helical structure; in many proteins this 28-region model hits many times in tandem. Arrangement of these sequences on a helical wheel would show a strict alternation of Leu and Gly residues on one side of the helix, that is, an extremely bulky side chain alternating with the virtual absence of one. This suggests an extended zippering of one alpha helix to another, analogous to the shorter leucine zippers found in many dimerizing transcription factors. Proteins in which these heptad repeats occur often have higher order repeats of a unit comprised of several heptads.


Pssm-ID: 274412  Cd Length: 28  Bit Score: 35.00  E-value: 4.53e-03
                          10        20
                  ....*....|....*....|....*..
gi 899764075  203 ANQLANGIDRLSDGTSKLKEGSDKLAS 229
Cdd:TIGR03057   1 SGQLADGAGQLASGAGQLASGANQLAD 27
Mtu_fam_mce TIGR00996
virulence factor Mce family protein; Members of this paralogous family are found as six tandem ...
 319-431 5.44e-03

virulence factor Mce family protein; Members of this paralogous family are found as six tandem homologous proteins in the same orientation per cassette, in four separate cassettes in Mycobacterium tuberculosis. The six members of each cassette represent six subfamilies. One subfamily includes the protein mce (mycobacterial cell entry), a virulence protein required for invasion of non-phagocytic cells. [Cellular processes, Pathogenesis]


Pssm-ID: 273384 [Multi-domain]  Cd Length: 291  Bit Score: 39.19  E-value: 5.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 899764075  319 KIVATSNGLAKATSTLNNSQQQLTQ---GAKKLTDGQHKIEEGMNTFGVKLNEATAGTKK----IADGASNLaDGFTKWG 391
Cdd:TIGR00996 168 QLRNLLDGLAQLTAALNERDGDIGElirNLNRVLDVLADRSDQLDRLLDNLPTLIATLADrsdaLDDALAAL-SAASAQV 246

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 899764075  392 NGF-----TSLQEGVNQLASGGTELNNGASKLTNGLVKLDDGAKE 431
Cdd:TIGR00996 247 RDLlaenrPNLGQALANLAPVLTLLVDYSPELEQLLHLLPTYAAN 291
 
Name Accession Description Interval E-value
pip_yhgE_Nterm TIGR03061
YhgE/Pip N-terminal domain; This family contains the N-terminal domain of a family of multiple ...
 9-172 4.69e-83

YhgE/Pip N-terminal domain; This family contains the N-terminal domain of a family of multiple membrane-spanning proteins of Gram-positive bacteria. One member was shown to be a host protein essential for phage infection, so many members of this family are called "phage infection protein". A separate model, TIGR03062, represents the conserved C-terminal domain. The domains are separated by regions highly variable in both length and sequence, often containing extended heptad repeats as described in model TIGR03057.


Pssm-ID: 274413 [Multi-domain]  Cd Length: 164  Bit Score: 259.06  E-value: 4.69e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 899764075    9 KDWKAMWHHKHGRIALIFLLIVPLIYSGFFLAGYWDPYGKLDKLPVAVVNLDKGAAMDEKTIHVGDDFVKNLKENKELAF 88
Cdd:TIGR03061   1 SELKRLRKNKLLRIALIAIMLIPLLYGGLFLWAFWDPYGNLDNLPVAVVNEDKGATYDGKTLNAGDDLVKELKKNDDLDW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 899764075   89 HFVSEKNADEGLKEDKYYMVVTIPEDFSKKVSTLMNEKPEPAKLQYKVNPGKNFVAAQIGTTAVENMKTKISNSITKSYT 168
Cdd:TIGR03061  81 HFVSAKEAEKGLADGKYYMVITIPEDFSENATSLLDDQPKKAQLIYKTNDANNYIASQIAESAAEKVKTSVSKSITETYA 160


                  ....
gi 899764075  169 EGVF 172
Cdd:TIGR03061 161 ETIF 164
pip_yhgE_Cterm TIGR03062
YhgE/Pip C-terminal domain; This family contains the C-terminal domain of a family of multiple ...
 454-658 7.23e-74

YhgE/Pip C-terminal domain; This family contains the C-terminal domain of a family of multiple membrane-spanning proteins of Gram-positive bacteria. One member was shown to be a host protein essential for phage infection, so many members of this family are called "phage infection protein". A separate model, TIGR03061, represents the conserved N-terminal domain. The domains are separated by regions highly variable in both length and sequence, often containing extended heptad repeats as described in model TIGR03057.


Pssm-ID: 274414 [Multi-domain]  Cd Length: 208  Bit Score: 236.70  E-value: 7.23e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 899764075  454 TMFSEPVQLVKSTVSDVPNYGSGIAPYFLSLAFYVGGIMASNILPLGRRQNMKVSGTVH--FINKLGLVYLIGLIQALLV 531
Cdd:TIGR03062   2 KMVAEPVKLKHSDYDDVPNYGTGLAPYFLSLALFVGALVLNLIFPPLSRRALPKSARSWriALAKLLPGGLIGVIQAIIL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 899764075  532 DVVVLGVMKLEVASVPLFVLSSIVISFTFMTFILMLVTVFGLVGKFLAVTLLVLQLATSGGTFPGELNIAVLSKIGQFLP 611
Cdd:TIGR03062  82 YGVLILALGLDPAHPPATFGFAILTSLTFMAIIQFLVALFGSVGRFLALVLLVLQLGSSGGTFPIELLPAFFQAIHPFLP 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 899764075  612 MSHSLRGLQDVISLGDWSQLQMQILILLCYLVVAGGIAWITSHIQHR 658
Cdd:TIGR03062 162 MTYSVNGLRQLISGGDDSTLWQAVAVLLLILVIFLALSLLSARRKRR 208
YhgE COG1511
Uncharacterized membrane protein YhgE, phage infection protein (PIP) family [Function unknown]; ...
 7-171 4.76e-70

Uncharacterized membrane protein YhgE, phage infection protein (PIP) family [Function unknown];


Pssm-ID: 441120  Cd Length: 225  Bit Score: 227.13  E-value: 4.76e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 899764075   7 IFKDWKAMWHHKHGRIALIFLLIVPLIYSGFFLAGYWDPYGKLDKLPVAVVNLDKGAAMDEKTIHVGDDFVKNLKENKEL 86
Cdd:COG1511    1 FKRELKRLFKNKLALIALIALILVPLLYAGLYLWAFWDPYGNLDNLPVAVVNEDKGATVDGKTVNLGDELVDELKDNDSF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 899764075  87 AFHFVSEKNADEGLKEDKYYMVVTIPEDFSKKVSTLMNEKPEPAKLQYKVNPGKNFVAAQIGTTAVENMKTKISNSITKS 166
Cdd:COG1511   81 DWQFVSEEEAEKGLKDGKYYAVIVIPEDFSANLASLLSDDPEKATITYYTNEANNYLASKITDTAATTVVDQVNSQVTET 160


                 ....*
gi 899764075 167 YTEGV 171
Cdd:COG1511  161 YAETV 165
T7_esaA_Nterm TIGR03929
type VII secretion protein EsaA, N-terminal domain; Members of this family are associated with ...
 24-210 2.76e-24

type VII secretion protein EsaA, N-terminal domain; Members of this family are associated with type VII secretion of WXG100 family targets in the Firmicutes, but not in the Actinobacteria. This model represents the conserved N-terminal domain.


Pssm-ID: 274861 [Multi-domain]  Cd Length: 193  Bit Score: 100.56  E-value: 2.76e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 899764075   24 LIFLLIVPLIYSGFFLAGYWDPYGK-----LDKLPVAVVNLDKGAAMDEKTIHVGDDFVKNLKENKELAFHFVSEKNADE 98
Cdd:TIGR03929   1 LIFLVLFIVLLPGLFFLAIGQNPKKqktnqNAKMNIAVVNEDQGVSFDGKTYNFGASFVKAIERDNSQEWSVVSRGAAEN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 899764075   99 GLKEDKYYMVVTIPEDFSKKVSTLMNEKPEPAKLQYKVNPGKNFVAAQIGTTAVENMKTKISNSITKSYTEGVFSKFQDl 178
Cdd:TIGR03929  81 GLKNNTYDAVVYIPSDFSKKVLSVNKENPEKATIQYKVNANGNAVLKEEAQREAEDILNDFNSQMSDLYWASILQNLQT- 159

                         170       180       190
                  ....*....|....*....|....*....|....
gi 899764075  179 AQGLSDASNGAEKLHEGT--TDAKNGANQLANGI 210
Cdd:TIGR03929 160 AQDNVQAIVNKEAEFQSTyyKNYLPSSANLTNQF 193
YhgE COG1511
Uncharacterized membrane protein YhgE, phage infection protein (PIP) family [Function unknown]; ...
 423-504 2.59e-10

Uncharacterized membrane protein YhgE, phage infection protein (PIP) family [Function unknown];


Pssm-ID: 441120  Cd Length: 225  Bit Score: 60.73  E-value: 2.59e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 899764075 423 VKLDDGAKELSTKLGE-GAEKIADVRNDDARNTMFS--EPVQLVKSTVSDVPNYGSGIAPYFLSLAFYVGGIMASNILPL 499
Cdd:COG1511  128 YYTNEANNYLASKITDtAATTVVDQVNSQVTETYAEtvSPVALKTEALNPVPNYGSGLAPFFLSLALWVGALLLFLLLRP 207


                 ....*
gi 899764075 500 GRRQN 504
Cdd:COG1511  208 LVDRA 212
ABC2_membrane_3 pfam12698
ABC-2 family transporter protein; This family is related to the ABC-2 membrane transporter ...
 24-166 4.30e-10

ABC-2 family transporter protein; This family is related to the ABC-2 membrane transporter family pfam01061.


Pssm-ID: 463674 [Multi-domain]  Cd Length: 345  Bit Score: 61.64  E-value: 4.30e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 899764075   24 LIFLLIVPLIYSGFFLAGYWDPYGKLDKLPVAVVNLDKGAAMDEktihvgddFVKNLKENKE--LAFHFVSEKNADEGLK 101
Cdd:pfam12698   4 LIITLLLPILLILLLGLIFSNAVNDPEELPVAVVDEDNSSLSRQ--------LVRALEASPTvnLVQYVDSEEEAKEALK 75

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 899764075  102 EDKYYMVVTIPEDFSKKVstlmnEKPEPAKLQYKVNpGKNFVAAQIGTTAVENMKTKISNSITKS 166
Cdd:pfam12698  76 NGKIDGLLVIPKGFSKDL-----LKGESATVTVYIN-SSNLLVSKLILNALQSLLQQLNASALVL 134
YadH COG0842
ABC-type multidrug transport system, permease component [Defense mechanisms];
544-652 5.18e-08

ABC-type multidrug transport system, permease component [Defense mechanisms];


Pssm-ID: 440604 [Multi-domain]  Cd Length: 200  Bit Score: 53.67  E-value: 5.18e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 899764075 544 ASVPLFVLSSIVISFTFMTFILMLVTVFGLVGKFLAVTLLVLQLAT--SGGTFPGELNIAVLSKIGQFLPMSHSLRGLQD 621
Cdd:COG0842   82 LSLLLLLLVLLLFALAFSGLGLLISTLARSQEQASAISNLVILPLTflSGAFFPIESLPGWLQAIAYLNPLTYFVEALRA 161

                         90       100       110
                 ....*....|....*....|....*....|..
gi 899764075 622 VISLG-DWSQLQMQILILLCYLVVAGGIAWIT 652
Cdd:COG0842  162 LFLGGaGLADVWPSLLVLLAFAVVLLALALRL 193
ABC2_membrane_3 pfam12698
ABC-2 family transporter protein; This family is related to the ABC-2 membrane transporter ...
 468-651 3.88e-07

ABC-2 family transporter protein; This family is related to the ABC-2 membrane transporter family pfam01061.


Pssm-ID: 463674 [Multi-domain]  Cd Length: 345  Bit Score: 52.78  E-value: 3.88e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 899764075  468 SDVPNYGSGIAPYFLSLAFYVGGIMASNIL------PLGRRQN-MKVSGTVHFINKLGLVYLIGLIQALLVDVVVLGVMk 540
Cdd:pfam12698 154 NPQSGYAYYLVGLILMIIILIGAAIIAVSIveekesRIKERLLvSGVSPLQYWLGKILGDFLVGLLQLLIILLLLFGIG- 232

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 899764075  541 LEVASVPLFVLSSIVISFTFMTFILMLVTVFG--LVGKFLAVTLLVLQLATSGGTFPGELNIAVLSKIGQFLPMSHSLRG 618
Cdd:pfam12698 233 IPFGNLGLLLLLFLLYGLAYIALGYLLGSLFKnsEDAQSIIGIVILLLSGFFGGLFPLEDPPSFLQWIFSIIPFFSPIDG 312

                         170       180       190
                  ....*....|....*....|....*....|...
gi 899764075  619 LQDVISLGDWSQLQMQILILLCYLVVAGGIAWI 651
Cdd:pfam12698 313 LLRLIYGDSLWEIAPSLIILLLFAVVLLLLALL 345
xxxLxxG_by_4 TIGR03057
X-X-X-Leu-X-X-Gly heptad repeats; This model represents a 28-column alignment, comprising four ...
 203-229 4.53e-03

X-X-X-Leu-X-X-Gly heptad repeats; This model represents a 28-column alignment, comprising four tandem sets of seven residues each, in which the fourth residue tends to be Leu and the seventh tends to be Gly in each set. This heptad periodicity, corresponding to two turns of an alpha helix, suggests alpha-helical structure; in many proteins this 28-region model hits many times in tandem. Arrangement of these sequences on a helical wheel would show a strict alternation of Leu and Gly residues on one side of the helix, that is, an extremely bulky side chain alternating with the virtual absence of one. This suggests an extended zippering of one alpha helix to another, analogous to the shorter leucine zippers found in many dimerizing transcription factors. Proteins in which these heptad repeats occur often have higher order repeats of a unit comprised of several heptads.


Pssm-ID: 274412  Cd Length: 28  Bit Score: 35.00  E-value: 4.53e-03
                          10        20
                  ....*....|....*....|....*..
gi 899764075  203 ANQLANGIDRLSDGTSKLKEGSDKLAS 229
Cdd:TIGR03057   1 SGQLADGAGQLASGAGQLASGANQLAD 27
Mtu_fam_mce TIGR00996
virulence factor Mce family protein; Members of this paralogous family are found as six tandem ...
 319-431 5.44e-03

virulence factor Mce family protein; Members of this paralogous family are found as six tandem homologous proteins in the same orientation per cassette, in four separate cassettes in Mycobacterium tuberculosis. The six members of each cassette represent six subfamilies. One subfamily includes the protein mce (mycobacterial cell entry), a virulence protein required for invasion of non-phagocytic cells. [Cellular processes, Pathogenesis]


Pssm-ID: 273384 [Multi-domain]  Cd Length: 291  Bit Score: 39.19  E-value: 5.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 899764075  319 KIVATSNGLAKATSTLNNSQQQLTQ---GAKKLTDGQHKIEEGMNTFGVKLNEATAGTKK----IADGASNLaDGFTKWG 391
Cdd:TIGR00996 168 QLRNLLDGLAQLTAALNERDGDIGElirNLNRVLDVLADRSDQLDRLLDNLPTLIATLADrsdaLDDALAAL-SAASAQV 246

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 899764075  392 NGF-----TSLQEGVNQLASGGTELNNGASKLTNGLVKLDDGAKE 431
Cdd:TIGR00996 247 RDLlaenrPNLGQALANLAPVLTLLVDYSPELEQLLHLLPTYAAN 291
xxxLxxG_by_4 TIGR03057
X-X-X-Leu-X-X-Gly heptad repeats; This model represents a 28-column alignment, comprising four ...
 401-428 7.71e-03

X-X-X-Leu-X-X-Gly heptad repeats; This model represents a 28-column alignment, comprising four tandem sets of seven residues each, in which the fourth residue tends to be Leu and the seventh tends to be Gly in each set. This heptad periodicity, corresponding to two turns of an alpha helix, suggests alpha-helical structure; in many proteins this 28-region model hits many times in tandem. Arrangement of these sequences on a helical wheel would show a strict alternation of Leu and Gly residues on one side of the helix, that is, an extremely bulky side chain alternating with the virtual absence of one. This suggests an extended zippering of one alpha helix to another, analogous to the shorter leucine zippers found in many dimerizing transcription factors. Proteins in which these heptad repeats occur often have higher order repeats of a unit comprised of several heptads.


Pssm-ID: 274412  Cd Length: 28  Bit Score: 34.23  E-value: 7.71e-03
                          10        20
                  ....*....|....*....|....*...
gi 899764075  401 VNQLASGGTELNNGASKLTNGLVKLDDG 428
Cdd:TIGR03057   1 SGQLADGAGQLASGAGQLASGANQLADG 28
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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