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Conserved domains on  [gi|891270367|gb|AKQ74438|]
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response regulator aspartate phosphatase [Bacillus licheniformis WX-02]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11419012)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
7-209 8.78e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 48.85  E-value: 8.78e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891270367   7 KNYLEAISCYKKAeaklhkLTDEIEKAEFYYKIATAYYQIDDHFRSLNYSEKALSLFSKHKEYIDKtigcemiLGSVQFE 86
Cdd:COG0457   22 GRYEEAIEDYEKA------LELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNN-------LGLALQA 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891270367  87 LFRIKQAEEHYgralDQAVALQNRRIIglIYHNMGLNYAKCGMPLLAEEHFRKALSIGVHEqsvfgINTLFELSHLMYKN 166
Cdd:COG0457   89 LGRYEEALEDY----DKALELDPDDAE--ALYNLGLALLELGRYDEAIEAYERALELDPDD-----ADALYNLGIALEKL 157

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 891270367 167 GSPEEARRLCKEGFTRSAELGEDEYAAKFRLIFALYDAGHPLD 209
Cdd:COG0457  158 GRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALL 200
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
7-209 8.78e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 48.85  E-value: 8.78e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891270367   7 KNYLEAISCYKKAeaklhkLTDEIEKAEFYYKIATAYYQIDDHFRSLNYSEKALSLFSKHKEYIDKtigcemiLGSVQFE 86
Cdd:COG0457   22 GRYEEAIEDYEKA------LELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNN-------LGLALQA 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891270367  87 LFRIKQAEEHYgralDQAVALQNRRIIglIYHNMGLNYAKCGMPLLAEEHFRKALSIGVHEqsvfgINTLFELSHLMYKN 166
Cdd:COG0457   89 LGRYEEALEDY----DKALELDPDDAE--ALYNLGLALLELGRYDEAIEAYERALELDPDD-----ADALYNLGIALEKL 157

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 891270367 167 GSPEEARRLCKEGFTRSAELGEDEYAAKFRLIFALYDAGHPLD 209
Cdd:COG0457  158 GRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALL 200
TPR_12 pfam13424
Tetratricopeptide repeat;
80-143 7.03e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 34.67  E-value: 7.03e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 891270367   80 LGSVQFELFRIKQAEEHYGRALDQAVALQ--NRRIIGLIYHNMGLNYAKCGMPLLAEEHFRKALSI 143
Cdd:pfam13424   9 LAAVLRRLGRYDEALELLEKALEIARRLLgpDHPLTATTLLNLGRLYLELGRYEEALELLERALAL 74
PRK08655 PRK08655
prephenate dehydrogenase; Provisional
 22-80 9.62e-03

prephenate dehydrogenase; Provisional


Pssm-ID: 236326 [Multi-domain]  Cd Length: 437  Bit Score: 36.89  E-value: 9.62e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 891270367  22 KLHKLTDEIEKAEFYYKIATAYYQIDDHFRSLNYSEKALSLFSKHKEYIDKTIGCEMIL 80
Cdd:PRK08655 247 ELSELVKNGDREEFVERMKEAAKHFGDTERALGRSDKAIYALNQEFEKLLKSIGKEIGL 305
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
7-209 8.78e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 48.85  E-value: 8.78e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891270367   7 KNYLEAISCYKKAeaklhkLTDEIEKAEFYYKIATAYYQIDDHFRSLNYSEKALSLFSKHKEYIDKtigcemiLGSVQFE 86
Cdd:COG0457   22 GRYEEAIEDYEKA------LELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNN-------LGLALQA 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891270367  87 LFRIKQAEEHYgralDQAVALQNRRIIglIYHNMGLNYAKCGMPLLAEEHFRKALSIGVHEqsvfgINTLFELSHLMYKN 166
Cdd:COG0457   89 LGRYEEALEDY----DKALELDPDDAE--ALYNLGLALLELGRYDEAIEAYERALELDPDD-----ADALYNLGIALEKL 157

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 891270367 167 GSPEEARRLCKEGFTRSAELGEDEYAAKFRLIFALYDAGHPLD 209
Cdd:COG0457  158 GRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALL 200
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
29-261 1.04e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 48.46  E-value: 1.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891270367  29 EIEKAEFYYKIATAYYQIDDHFRSLNYSEKALSLFSKHKEYIdktigceMILGSVQFELFRIKQAEEHYgralDQAVALQ 108
Cdd:COG0457    4 DPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEAL-------YNLGLAYLRLGRYEEALADY----EQALELD 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891270367 109 NRRIIglIYHNMGLNYAKCGMPLLAEEHFRKALSIGVHEqsvfgINTLFELSHLMYKNGSPEEARRLckegFTRSAELGE 188
Cdd:COG0457   73 PDDAE--ALNNLGLALQALGRYEEALEDYDKALELDPDD-----AEALYNLGLALLELGRYDEAIEA----YERALELDP 141

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 891270367 189 DEYAAKFRLIFALYDAGHPLDIEFSLEYMSDKRLWPHVAELTKDIADYYMKSGDHEKSALYLEKSQHAKNQIY 261
Cdd:COG0457  142 DDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAIL 214
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 80-217 9.23e-06

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 46.52  E-value: 9.23e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891270367  80 LGSVQFELFRIKQAEEHYGRALDQAVALqnrriiGLIYHNMGLNYAKCGMPLLAEEHFRKALSIGVHEqsvfgINTLFEL 159
Cdd:COG3914  118 LGNLLLALGRLEEALAALRRALALNPDF------AEAYLNLGEALRRLGRLEEAIAALRRALELDPDN-----AEALNNL 186

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 891270367 160 SHLMYKNGSPEEARRLckegFTRSAELGEDEYAAKFRLIFALYDAGHPLDIEFSLEYM 217
Cdd:COG3914  187 GNALQDLGRLEEAIAA----YRRALELDPDNADAHSNLLFALRQACDWEVYDRFEELL 240
COG3899 COG3899
Predicted ATPase [General function prediction only];
9-204 1.61e-04

Predicted ATPase [General function prediction only];


Pssm-ID: 443106 [Multi-domain]  Cd Length: 1244  Bit Score: 42.92  E-value: 1.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891270367    9 YLEAISCYKKAEAKLHKLTDEIEKAEFYYKIATAYYQIDDHFRSLNYSEKALSLFSKH----KEYIDKTIGCEMILGSVQ 84
Cdd:COG3899   721 YAEALRYLERALELLPPDPEEEYRLALLLELAEALYLAGRFEEAEALLERALAARALAalaaLRHGNPPASARAYANLGL 800

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891270367   85 FELFRIKQAEEHYGRALDQAVALQNRRIIGLIYHNMGLNYAKCGMPLLAEEHFRKALSIGVHEQSVFGINTLFELSHLMY 164
Cdd:COG3899   801 LLLGDYEEAYEFGELALALAERLGDRRLEARALFNLGFILHWLGPLREALELLREALEAGLETGDAALALLALAAAAAAA 880

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 891270367  165 KNGSPEEARRLCKEGFTRSAELGEDEYAAKFRLIFALYDA 204
Cdd:COG3899   881 AAAAALAAAAAAAARLLAAAAAALAAAAAAAALAAAELAR 920
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 84-206 3.28e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 41.90  E-value: 3.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891270367  84 QFELFRIKQAEEHYGRALDQAVALqnrriiGLIYHNMGLNYAKCGMPLLAEEHFRKALSIGvHEQSVFGINtlfeLSHLM 163
Cdd:COG3914   88 LQALGRYEEALALYRRALALNPDN------AEALFNLGNLLLALGRLEEALAALRRALALN-PDFAEAYLN----LGEAL 156

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 891270367 164 YKNGSPEEARRLCKegftRSAELGEDEYAAKFRLIFALYDAGH 206
Cdd:COG3914  157 RRLGRLEEAIAALR----RALELDPDNAEALNNLGNALQDLGR 195
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 6-175 3.29e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 41.25  E-value: 3.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891270367   6 EKNYLEAISCYKKAEAklhkltDEIEKAEFYYKIATAYYQIDDHFRSLNYSEKALSLFSKHKEYIdktigceMILGSVQF 85
Cdd:COG2956  123 EGDWEKAIEVLERLLK------LGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARAL-------LLLAELYL 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891270367  86 ELFRIKQAEEHYGRALDQAVALQNrriiglIYHNMGLNYAKCGMPLLAEEHFRKALsigvheQSVFGINTLFELSHLMYK 165
Cdd:COG2956  190 EQGDYEEAIAALERALEQDPDYLP------ALPRLAELYEKLGDPEEALELLRKAL------ELDPSDDLLLALADLLER 257

                        170
                 ....*....|
gi 891270367 166 NGSPEEARRL 175
Cdd:COG2956  258 KEGLEAALAL 267
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 8-113 3.97e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 36.52  E-value: 3.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 891270367   8 NYLEAISCYKKAeaklhkLTDEIEKAEFYYKIATAYYQIDDHFRSLNYSEKALSLFSKHKEYIdktigceMILGSVQFEL 87
Cdd:COG4235   32 RYDEALAAYEKA------LRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEAL-------YLLGLAAFQQ 98

                         90       100
                 ....*....|....*....|....*.
gi 891270367  88 FRIKQAEEHYGRALDQAVALQNRRII 113
Cdd:COG4235   99 GDYAEAIAAWQKLLALLPADAPARLL 124
TPR_12 pfam13424
Tetratricopeptide repeat;
80-143 7.03e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 34.67  E-value: 7.03e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 891270367   80 LGSVQFELFRIKQAEEHYGRALDQAVALQ--NRRIIGLIYHNMGLNYAKCGMPLLAEEHFRKALSI 143
Cdd:pfam13424   9 LAAVLRRLGRYDEALELLEKALEIARRLLgpDHPLTATTLLNLGRLYLELGRYEEALELLERALAL 74
PRK08655 PRK08655
prephenate dehydrogenase; Provisional
 22-80 9.62e-03

prephenate dehydrogenase; Provisional


Pssm-ID: 236326 [Multi-domain]  Cd Length: 437  Bit Score: 36.89  E-value: 9.62e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 891270367  22 KLHKLTDEIEKAEFYYKIATAYYQIDDHFRSLNYSEKALSLFSKHKEYIDKTIGCEMIL 80
Cdd:PRK08655 247 ELSELVKNGDREEFVERMKEAAKHFGDTERALGRSDKAIYALNQEFEKLLKSIGKEIGL 305
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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