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Conserved domains on  [gi|846150001|gb|AKN18446|]
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serine/threonine protein kinase [Mycobacterium haemophilum DSM 44634]

Protein Classification

anti-sigma regulatory factor( domain architecture ID 13014755)

anti-sigma regulatory factor similar to RsbT, an ATPase with serine/threonine kinase activity that phosphorylates its antagonist RsbS and stimulates the phosphatase RsbU in a signaling cascade that results in active sigma-B

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HATPase_RsbT-like cd16934
Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine ...
 10-122 3.75e-32

Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine/threonine-protein kinase RsbT, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of Bacillus subtilis serine/threonine-protein kinase RsbT, a component of the stressosome signaling complex of Bacillus subtilis. The stressosome is formed from multiple copies of three proteins, a sensor protein RsbR, a scaffold protein RsbS, and RsbT, and responds to environmental changes by initiating a protein partner switching cascade. Stress perception increases the phosphorylation of RsbR and RsbS, by RsbT. Subsequent dissociation of RsbT from the stressosome activates the sigma-B cascade, leading to the release of the alternative sigma factor, sigma-B.


:

Pssm-ID: 340411 [Multi-domain]  Cd Length: 117  Bit Score: 109.77  E-value: 3.75e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 846150001  10 DIVAARKAGHQLALDLGFSLTDVTMIATAISEVARNITSYAGHGLVRVAVEDREGRKALVVRAEDDGPGIADIERAMEDG 89
Cdd:cd16934    1 DVVDARRAARELARRLGLSEVRQAEIATAVTELARNLLKHAGGGQVLLEVVAEGGRVALEILAVDQGPGIADVDEALRDG 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 846150001  90 YSTARGLGLGLPGARRLMDRLMVESALGHGTVV 122
Cdd:cd16934   81 FSTGGGLGLGLGGVRRLADEFDLHSAPGRGTVV 113
 
Name Accession Description Interval E-value
HATPase_RsbT-like cd16934
Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine ...
 10-122 3.75e-32

Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine/threonine-protein kinase RsbT, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of Bacillus subtilis serine/threonine-protein kinase RsbT, a component of the stressosome signaling complex of Bacillus subtilis. The stressosome is formed from multiple copies of three proteins, a sensor protein RsbR, a scaffold protein RsbS, and RsbT, and responds to environmental changes by initiating a protein partner switching cascade. Stress perception increases the phosphorylation of RsbR and RsbS, by RsbT. Subsequent dissociation of RsbT from the stressosome activates the sigma-B cascade, leading to the release of the alternative sigma factor, sigma-B.


Pssm-ID: 340411 [Multi-domain]  Cd Length: 117  Bit Score: 109.77  E-value: 3.75e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 846150001  10 DIVAARKAGHQLALDLGFSLTDVTMIATAISEVARNITSYAGHGLVRVAVEDREGRKALVVRAEDDGPGIADIERAMEDG 89
Cdd:cd16934    1 DVVDARRAARELARRLGLSEVRQAEIATAVTELARNLLKHAGGGQVLLEVVAEGGRVALEILAVDQGPGIADVDEALRDG 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 846150001  90 YSTARGLGLGLPGARRLMDRLMVESALGHGTVV 122
Cdd:cd16934   81 FSTGGGLGLGLGGVRRLADEFDLHSAPGRGTVV 113
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
8-128 3.19e-23

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 87.28  E-value: 3.19e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 846150001   8 PDDIVAARKAGHQLALDLGFSLTDVTMIATAISEVARNITSYAGH----GLVRVAVEDREGRkaLVVRAEDDGPGIADie 83
Cdd:COG2172    8 LEDLGLARRAVRALLRELGLDEDDADDLVLAVSEAVTNAVRHAYGgdpdGPVEVELELDPDG--LEIEVRDEGPGFDP-- 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 846150001  84 RAMEDGYSTARGLGLGLPGARRLMDRLMVESALGhGTVVEMWKWV 128
Cdd:COG2172   84 EDLPDPYSTLAEGGRGLFLIRRLMDEVEYESDPG-GTTVRLVKRL 127
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 30-125 2.58e-11

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 56.50  E-value: 2.58e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 846150001    30 TDVTMIATAISEVARNITSYAGH-GLVRVAVEDREGRkaLVVRAEDDGPGIA--DIERAMEDGYSTAR------GLGLGL 100
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTPEgGRITVTLERDGDH--VEITVEDNGPGIPpeDLEKIFEPFFRTDKrsrkigGTGLGL 78

                           90       100
                   ....*....|....*....|....*....
gi 846150001   101 PGARRLMD----RLMVESALGHGTVVEMW 125
Cdd:smart00387  79 SIVKKLVElhggEISVESEPGGGTTFTIT 107
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 30-125 2.94e-08

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 48.52  E-value: 2.94e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 846150001   30 TDVTMIATAISEVARNI---TSYAGHGLVRVAVEDRegrkaLVVRAEDDGPGI--ADIERAMEDGYSTAR----GLGLGL 100
Cdd:pfam02518   1 GDELRLRQVLSNLLDNAlkhAAKAGEITVTLSEGGE-----LTLTVEDNGIGIppEDLPRIFEPFSTADKrgggGTGLGL 75

                          90       100
                  ....*....|....*....|....*....
gi 846150001  101 PGARRLMD----RLMVESALGHGTVVEMW 125
Cdd:pfam02518  76 SIVRKLVEllggTITVESEPGGGTTVTLT 104
envZ PRK09467
osmolarity sensor protein; Provisional
 10-109 3.07e-05

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 41.82  E-value: 3.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 846150001  10 DIVAAR-KAGHQLALDLGFSLTDVTMIATAISEVARNITSYA---GHGlvRVAVEDREGRKALVVRAEDDGPGI--ADIE 83
Cdd:PRK09467 302 EVIAAEsGYEREIETALQPGPIEVPMNPIAIKRALANLVVNAaryGNG--WIKVSSGTEGKRAWFQVEDDGPGIppEQLK 379

                         90       100       110
                 ....*....|....*....|....*....|....
gi 846150001  84 RAME-----DgysTAR---GLGLGLPGARRLMDR 109
Cdd:PRK09467 380 HLFQpftrgD---SARgssGTGLGLAIVKRIVDQ 410
 
Name Accession Description Interval E-value
HATPase_RsbT-like cd16934
Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine ...
 10-122 3.75e-32

Histidine kinase-like ATPase domain of the anti sigma-B factor Bacillus subtilis serine/threonine-protein kinase RsbT, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of Bacillus subtilis serine/threonine-protein kinase RsbT, a component of the stressosome signaling complex of Bacillus subtilis. The stressosome is formed from multiple copies of three proteins, a sensor protein RsbR, a scaffold protein RsbS, and RsbT, and responds to environmental changes by initiating a protein partner switching cascade. Stress perception increases the phosphorylation of RsbR and RsbS, by RsbT. Subsequent dissociation of RsbT from the stressosome activates the sigma-B cascade, leading to the release of the alternative sigma factor, sigma-B.


Pssm-ID: 340411 [Multi-domain]  Cd Length: 117  Bit Score: 109.77  E-value: 3.75e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 846150001  10 DIVAARKAGHQLALDLGFSLTDVTMIATAISEVARNITSYAGHGLVRVAVEDREGRKALVVRAEDDGPGIADIERAMEDG 89
Cdd:cd16934    1 DVVDARRAARELARRLGLSEVRQAEIATAVTELARNLLKHAGGGQVLLEVVAEGGRVALEILAVDQGPGIADVDEALRDG 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 846150001  90 YSTARGLGLGLPGARRLMDRLMVESALGHGTVV 122
Cdd:cd16934   81 FSTGGGLGLGLGGVRRLADEFDLHSAPGRGTVV 113
RsbW COG2172
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
8-128 3.19e-23

Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];


Pssm-ID: 441775 [Multi-domain]  Cd Length: 127  Bit Score: 87.28  E-value: 3.19e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 846150001   8 PDDIVAARKAGHQLALDLGFSLTDVTMIATAISEVARNITSYAGH----GLVRVAVEDREGRkaLVVRAEDDGPGIADie 83
Cdd:COG2172    8 LEDLGLARRAVRALLRELGLDEDDADDLVLAVSEAVTNAVRHAYGgdpdGPVEVELELDPDG--LEIEVRDEGPGFDP-- 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 846150001  84 RAMEDGYSTARGLGLGLPGARRLMDRLMVESALGhGTVVEMWKWV 128
Cdd:COG2172   84 EDLPDPYSTLAEGGRGLFLIRRLMDEVEYESDPG-GTTVRLVKRL 127
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 30-125 2.58e-11

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 56.50  E-value: 2.58e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 846150001    30 TDVTMIATAISEVARNITSYAGH-GLVRVAVEDREGRkaLVVRAEDDGPGIA--DIERAMEDGYSTAR------GLGLGL 100
Cdd:smart00387   1 GDPDRLRQVLSNLLDNAIKYTPEgGRITVTLERDGDH--VEITVEDNGPGIPpeDLEKIFEPFFRTDKrsrkigGTGLGL 78

                           90       100
                   ....*....|....*....|....*....
gi 846150001   101 PGARRLMD----RLMVESALGHGTVVEMW 125
Cdd:smart00387  79 SIVKKLVElhggEISVESEPGGGTTFTIT 107
BaeS COG0642
Signal transduction histidine kinase [Signal transduction mechanisms];
13-125 3.55e-10

Signal transduction histidine kinase [Signal transduction mechanisms];


Pssm-ID: 440407 [Multi-domain]  Cd Length: 328  Bit Score: 56.07  E-value: 3.55e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 846150001  13 AARKAGHQLALDLGFSLTDVTMIATAISEVARNITSYA-----GHGLVRVAVEDREGRKALVVraEDDGPGIA--DIERA 85
Cdd:COG0642  198 LAEEKGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAikytpEGGTVTVSVRREGDRVRISV--EDTGPGIPpeDLERI 275

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 846150001  86 MEDGYSTAR-----GLGLGLPGARRLMD----RLMVESALGHGTVVEMW 125
Cdd:COG0642  276 FEPFFRTDPsrrggGTGLGLAIVKRIVElhggTIEVESEPGKGTTFTVT 324
HATPase_SpoIIAB-like cd16942
Histidine kinase-like ATPase domain of SpoIIAB, an anti sigma-F factor and serine-protein ...
 28-126 8.98e-10

Histidine kinase-like ATPase domain of SpoIIAB, an anti sigma-F factor and serine-protein kinase involved in regulating sigma-F during sporulation in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of SpoIIAB, an anti sigma-F factor and a serine-protein kinase involved in regulating sigma-F during sporulation in Bacilli where, early in sporulation, the cell divides into two unequal compartments: a larger mother cell and a smaller forespore. Sigma-F transcription factor is activated in the forespore directly after the asymmetric septum forms, and its spatial and temporal activation is required for sporulation. Free sigma-F can associate with the RNA polymerase core and activate transcription of the sigma-F regulon, its regulation may comprise a partner-switching mechanism involving SpoIIAB, SpoIIAA, and sigma-F as follows: SpoIIAB can form alternative complexes with either: i) sigma-F, holding it in an inactive form and preventing its association with RNA polymerase, or ii) unphosphorylated SpoIIAA and a nucleotide, either ATP or ADP. In the presence of ATP, SpoIIAB acts as a kinase to specifically phosphorylate a serine residue of SpoIIAA; this phosphorylated form has low affinity for SpoIIAB and dissociates, making SpoIIAB available to capture sigma-F. SpoIIAA may then be dephosphorylated by a SpoIIE serine phosphatase and be free to attack the SpoIIAB sigma-F complex to induce the release of sigma-F.


Pssm-ID: 340418 [Multi-domain]  Cd Length: 135  Bit Score: 52.93  E-value: 8.98e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 846150001  28 SLTDVTMIATAISEVARN--ITSYA--GHGLVRVAVEDREGRKALVVRaeDDGPGIADIERAMEDGYSTARGL---GLGL 100
Cdd:cd16942   32 TIDELTEIKTVVSEAVTNaiIHGYNndPNGIVSISVIIEDGVVHLTVR--DEGVGIPDIEEARQPLFTTKPELersGMGF 109

                         90       100
                 ....*....|....*....|....*.
gi 846150001 101 PGARRLMDRLMVESALGHGTVVEMWK 126
Cdd:cd16942  110 TIMENFMDEVIVESEVNKGTTVYLKK 135
KdpD COG2205
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
14-125 1.23e-09

K+-sensing histidine kinase KdpD [Signal transduction mechanisms];


Pssm-ID: 441807 [Multi-domain]  Cd Length: 239  Bit Score: 54.14  E-value: 1.23e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 846150001  14 ARKAGHQLALDLGFSL----TDVTMIATAISEVARNITSYAG-HGLVRVAVEDREGRkaLVVRAEDDGPGI--ADIERAM 86
Cdd:COG2205  108 AEEKGIRLELDLPPELplvyADPELLEQVLANLLDNAIKYSPpGGTITISARREGDG--VRISVSDNGPGIpeEELERIF 185

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 846150001  87 EDGY-----STARGLGLGLPGARRLMD----RLMVESALGHGTVVEMW 125
Cdd:COG2205  186 ERFYrgdnsRGEGGTGLGLAIVKRIVEahggTIWVESEPGGGTTFTVT 233
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 30-125 2.94e-08

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 48.52  E-value: 2.94e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 846150001   30 TDVTMIATAISEVARNI---TSYAGHGLVRVAVEDRegrkaLVVRAEDDGPGI--ADIERAMEDGYSTAR----GLGLGL 100
Cdd:pfam02518   1 GDELRLRQVLSNLLDNAlkhAAKAGEITVTLSEGGE-----LTLTVEDNGIGIppEDLPRIFEPFSTADKrgggGTGLGL 75

                          90       100
                  ....*....|....*....|....*....
gi 846150001  101 PGARRLMD----RLMVESALGHGTVVEMW 125
Cdd:pfam02518  76 SIVRKLVEllggTITVESEPGGGTTVTLT 104
COG4191 COG4191
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
 14-125 2.80e-07

Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];


Pssm-ID: 443345 [Multi-domain]  Cd Length: 361  Bit Score: 47.87  E-value: 2.80e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 846150001  14 ARKAGHQLALDLGFSLTDVTMIATAISEVARNITSYA-------GHGLVRVAVEDREGRKALVVRaeDDGPGIAD--IER 84
Cdd:COG4191  232 LKARGIEVELDLPPDLPPVLGDPGQLEQVLLNLLINAidameegEGGRITISTRREGDYVVISVR--DNGPGIPPevLER 309

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 846150001  85 AMEDGYST---ARGLGLGLPGARRLMD----RLMVESALGHGTVVEMW 125
Cdd:COG4191  310 IFEPFFTTkpvGKGTGLGLSISYGIVEkhggRIEVESEPGGGTTFTIT 357
NtrY COG5000
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ...
 50-125 2.87e-07

Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];


Pssm-ID: 444024 [Multi-domain]  Cd Length: 422  Bit Score: 47.65  E-value: 2.87e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 846150001  50 AGHGLVRVAVEDREGRKALVVraEDDGPGIA--DIERAMEDGYST-ARGLGLGLPGARRLMD----RLMVESALGHGTVV 122
Cdd:COG5000  334 EEGGEIEVSTRREDGRVRIEV--SDNGPGIPeeVLERIFEPFFTTkPKGTGLGLAIVKKIVEehggTIELESRPGGGTTF 411


                 ...
gi 846150001 123 EMW 125
Cdd:COG5000  412 TIR 414
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
46-124 1.51e-06

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 45.78  E-value: 1.51e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 846150001  46 ITSYAGHGLVRVAVEDREGRkaLVVRAEDDGPGI--ADIERAMEDGYSTARGLGLGLPGAR-RLM------DRLMVESAL 116
Cdd:COG2972  353 IEPKEGGGTIRISIRKEGDR--LVITVEDNGVGMpeEKLEKLLEELSSKGEGRGIGLRNVReRLKlyygeeYGLEIESEP 430


                 ....*...
gi 846150001 117 GHGTVVEM 124
Cdd:COG2972  431 GEGTTVTI 438
CitA COG3290
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ...
 14-123 2.14e-06

Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];


Pssm-ID: 442519 [Multi-domain]  Cd Length: 389  Bit Score: 45.22  E-value: 2.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 846150001  14 ARKAGHQLALDLGFSLTDVTMIATAISEVARNI---------TSYAGHGLVRVAVEDREGRkaLVVRAEDDGPGIAD--I 82
Cdd:COG3290  257 ARERGIDLTIDIDSDLPDLPLSDTDLVTILGNLldnaieaveKLPEEERRVELSIRDDGDE--LVIEVEDSGPGIPEelL 334

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 846150001  83 ERAMEDGYST----ARGLGLGLpgARRLMDR----LMVESALGHGTVVE 123
Cdd:COG3290  335 EKIFERGFSTklgeGRGLGLAL--VKQIVEKyggtIEVESEEGEGTVFT 381
WalK COG5002
Sensor histidine kinase WalK [Signal transduction mechanisms];
14-125 4.07e-06

Sensor histidine kinase WalK [Signal transduction mechanisms];


Pssm-ID: 444026 [Multi-domain]  Cd Length: 390  Bit Score: 44.54  E-value: 4.07e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 846150001  14 ARKAGHQLALDLGFSLTDVTMIATAISEVARNITSYA-----GHGLVRVAVEDREGRkaLVVRAEDDGPGIA--DIERAM 86
Cdd:COG5002  257 AEEKGIELELDLPEDPLLVLGDPDRLEQVLTNLLDNAikytpEGGTITVSLREEDDQ--VRISVRDTGIGIPeeDLPRIF 334

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 846150001  87 EDGY----STAR---GLGLGLPGARRLMD----RLMVESALGHGTVVEMW 125
Cdd:COG5002  335 ERFYrvdkSRSRetgGTGLGLAIVKHIVEahggRIWVESEPGKGTTFTIT 384
envZ PRK09467
osmolarity sensor protein; Provisional
 10-109 3.07e-05

osmolarity sensor protein; Provisional


Pssm-ID: 236531 [Multi-domain]  Cd Length: 435  Bit Score: 41.82  E-value: 3.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 846150001  10 DIVAAR-KAGHQLALDLGFSLTDVTMIATAISEVARNITSYA---GHGlvRVAVEDREGRKALVVRAEDDGPGI--ADIE 83
Cdd:PRK09467 302 EVIAAEsGYEREIETALQPGPIEVPMNPIAIKRALANLVVNAaryGNG--WIKVSSGTEGKRAWFQVEDDGPGIppEQLK 379

                         90       100       110
                 ....*....|....*....|....*....|....
gi 846150001  84 RAME-----DgysTAR---GLGLGLPGARRLMDR 109
Cdd:PRK09467 380 HLFQpftrgD---SARgssGTGLGLAIVKRIVDQ 410
PRK11360 PRK11360
two-component system sensor histidine kinase AtoS;
53-124 4.03e-05

two-component system sensor histidine kinase AtoS;


Pssm-ID: 236901 [Multi-domain]  Cd Length: 607  Bit Score: 41.88  E-value: 4.03e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 846150001  53 GLVRVAVEdREGRKALVVRAEDDGPGIA--DIERAMEDGYST-ARGLGLGLPGARRLMD----RLMVESALGHGTVVEM 124
Cdd:PRK11360 520 GKIRIRTW-QYSDGQVAVSIEDNGCGIDpeLLKKIFDPFFTTkAKGTGLGLALSQRIINahggDIEVESEPGVGTTFTL 597
HATPase_DpiB-CitA-like cd16915
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 56-121 5.30e-05

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.


Pssm-ID: 340392 [Multi-domain]  Cd Length: 104  Bit Score: 39.58  E-value: 5.30e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 846150001  56 RVAVEDREGRKALVVRAEDDGPGIA--DIERAMEDGYST--ARGLGLGLPGARRLMDRL----MVESALGHGTV 121
Cdd:cd16915   25 QVEVFLRDEGDDLVIEVRDTGPGIApeLRDKVFERGVSTkgQGERGIGLALVRQSVERLggsiTVESEPGGGTT 98
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
57-125 5.82e-05

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 40.99  E-value: 5.82e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 846150001  57 VAVEDREGRKALVVRAEDDGPGIAD--IERAMEDGYST-ARGLGLGLPGARRLMDR----LMVESALGHGTVVEMW 125
Cdd:COG3852  276 VTLGGLRPRLYVRIEVIDNGPGIPEeiLDRIFEPFFTTkEKGTGLGLAIVQKIVEQhggtIEVESEPGKGTTFRIY 351
PRK11100 PRK11100
sensory histidine kinase CreC; Provisional
 52-125 6.16e-05

sensory histidine kinase CreC; Provisional


Pssm-ID: 236846 [Multi-domain]  Cd Length: 475  Bit Score: 40.98  E-value: 6.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 846150001  52 HGLVRVAVEDREGRKALVVRaeDDGPGIAD--IERAMEDGYSTAR------GLGLGLPGARRLMD----RLMVESALGHG 119
Cdd:PRK11100 387 GGTITLSAEVDGEQVALSVE--DQGPGIPDyaLPRIFERFYSLPRpangrkSTGLGLAFVREVARlhggEVTLRNRPEGG 464


                 ....*.
gi 846150001 120 TVVEMW 125
Cdd:PRK11100 465 VLATLT 470
COG4192 COG4192
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ...
 55-122 4.80e-04

Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];


Pssm-ID: 443346 [Multi-domain]  Cd Length: 640  Bit Score: 38.51  E-value: 4.80e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 846150001  55 VRVAVEDREGRKALVVRAEDDGPGIADIERAMEDGYSTAR-GLGLGLPGARRLMDR----LMVESALGHGTVV 122
Cdd:COG4192  563 PQISVDLLSNAENLRVAISDNGNGWPLVDKLFTPFTTTKEvGLGLGLSICRSIMQQfggdLYLASTLERGAMV 635
HATPase_RsbW-like cd16936
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ...
 35-124 1.46e-03

Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.


Pssm-ID: 340413 [Multi-domain]  Cd Length: 91  Bit Score: 35.32  E-value: 1.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 846150001  35 IATAISEVARNITSYA----GHGLVRVAVEDREGRkaLVVRAEDDGPGIaDIERAMEDGYSTARGlGLGLPGARRLMDRL 110
Cdd:cd16936    1 VELAVSEAVTNAVRHAyrhdGPGPVRLELDLDPDR--LRVEVTDSGPGF-DPLRPADPDAGLREG-GRGLALIRALMDEV 76

                         90
                 ....*....|....
gi 846150001 111 MVEsALGHGTVVEM 124
Cdd:cd16936   77 GYR-RTPGGKTVWL 89
HATPase_BasS-like cd16940
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 32-125 3.07e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.


Pssm-ID: 340417 [Multi-domain]  Cd Length: 113  Bit Score: 35.07  E-value: 3.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 846150001  32 VTMIATAISEVARNITS----YAGHG-LVRVAVEDREGRkalVVRAEDDGPGIA--DIERAMEDGY----STARGLGLGL 100
Cdd:cd16940    7 VQGDALLLFLLLRNLVDnavrYSPQGsRVEIKLSADDGA---VIRVEDNGPGIDeeELEALFERFYrsdgQNYGGSGLGL 83

                         90       100
                 ....*....|....*....|....*....
gi 846150001 101 PGARRLMD----RLMVESALGHGTVVEMW 125
Cdd:cd16940   84 SIVKRIVElhggQIFLGNAQGGGLEAWVR 112
glnL PRK11073
nitrogen regulation protein NR(II);
3-118 4.00e-03

nitrogen regulation protein NR(II);


Pssm-ID: 182947 [Multi-domain]  Cd Length: 348  Bit Score: 35.83  E-value: 4.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 846150001   3 VDIDNPDDIVAARkaghqlalDLGFSLTDVTMIATAISEVARNITSYA------GHGLVR--------VAVEDREGRKAL 68
Cdd:PRK11073 210 VSLELPDNVRLIR--------DYDPSLPELAHDPDQIEQVLLNIVRNAlqalgpEGGTITlrtrtafqLTLHGERYRLAA 281

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 846150001  69 VVRAEDDGPGI-ADIERAMEDGYSTAR--GLGLGLPGARRLMD----RLMVESALGH 118
Cdd:PRK11073 282 RIDIEDNGPGIpPHLQDTLFYPMVSGRegGTGLGLSIARNLIDqhsgKIEFTSWPGH 338
HATPase_YpdA-like cd16955
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 46-125 4.28e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli YpdA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli YpdA, a HK of the two-component system (TCS) YpdA-YpdB which is involved in a nutrient sensing regulatory network with YehU-YehT. Proteins having this HATPase domain also contain a histidine kinase domain (His-kinase), and some have a GAF sensor domain; some contain a DUF3816 domain; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340431 [Multi-domain]  Cd Length: 102  Bit Score: 34.36  E-value: 4.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 846150001  46 ITSYAGHGLVRVAVEDREGRKaLVVRAEDDGPGIAD--IERAMEDGYSTaRGLGLGLPGAR-RLM--DRLMVESALGHGT 120
Cdd:cd16955   18 IQEKKGKGVVKISVKKQLKNR-LHIAVEDNGIGISPkvIERVEQDEMPG-NKIGLLNVHQRlKLGygEGLHIRSRPDPGT 95


                 ....*
gi 846150001 121 VVEMW 125
Cdd:cd16955   96 LIAFY 100
HATPase_UhpB-NarQ-NarX-like cd16917
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 56-124 4.35e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.


Pssm-ID: 340394 [Multi-domain]  Cd Length: 87  Bit Score: 34.07  E-value: 4.35e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 846150001  56 RVAVEDREGRKALVVRAEDDGPGIADIERamedgystARGLGLGLPG----ARRLMDRLMVESALGHGTVVEM 124
Cdd:cd16917   20 RVRVTLSYTADELTLTVVDDGVGFDGPAP--------PGGGGFGLLGmrerAELLGGTLTIGSRPGGGTRVTA 84
PRK11086 PRK11086
sensory histidine kinase DcuS; Provisional
 14-120 4.38e-03

sensory histidine kinase DcuS; Provisional


Pssm-ID: 236839 [Multi-domain]  Cd Length: 542  Bit Score: 35.66  E-value: 4.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 846150001  14 ARKAGHQLALDLGFSLTD----------VTMIATAIsEVARNITSYAGHGLVRVAVEDREGRkaLVVRAEDDGPGIA--D 81
Cdd:PRK11086 407 ARELGITLIISEDSQLPDsgdedqvhelITILGNLI-ENALEAVGGEEGGEISVSLHYRNGW--LHCEVSDDGPGIApdE 483

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 846150001  82 IERAMEDGYSTA---RGLGLGL--PGARRLMDRLMVESALGHGT 120
Cdd:PRK11086 484 IDAIFDKGYSTKgsnRGVGLYLvkQSVENLGGSIAVESEPGVGT 527
HATPase_TmoS-FixL-DctS-like cd16920
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ...
 62-121 6.14e-03

Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.


Pssm-ID: 340397 [Multi-domain]  Cd Length: 104  Bit Score: 33.91  E-value: 6.14e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 846150001  62 REGRKALVVRAEDDGPGIAD--IERAMEDGYST-ARGLGLGLPGARRLMD----RLMVESALGHGTV 121
Cdd:cd16920   32 PADDRAVTISVKDTGPGIAEevAGQLFDPFYTTkSEGLGMGLSICRSIIEahggRLSVESPAGGGAT 98
PRK13837 PRK13837
two-component system VirA-like sensor kinase;
9-125 6.24e-03

two-component system VirA-like sensor kinase;


Pssm-ID: 237526 [Multi-domain]  Cd Length: 828  Bit Score: 35.42  E-value: 6.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 846150001   9 DDIVAARKAGHQLALDLGFSLTDVTMIATA----ISEVARNITSYA-----GHGLVRVAVEDREGRKAL----------- 68
Cdd:PRK13837 527 TEIAPLLRVSLPPGVELDFDQDQEPAVVEGnpaeLQQVLMNLCSNAaqamdGAGRVDISLSRAKLRAPKvlshgvlppgr 606

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 846150001  69 --VVRAEDDGPGI--ADIERAMEDGYST-ARGLGLGLPGARRLMD----RLMVESALGHGTVVEMW 125
Cdd:PRK13837 607 yvLLRVSDTGAGIdeAVLPHIFEPFFTTrAGGTGLGLATVHGIVSahagYIDVQSTVGRGTRFDVY 672
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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