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Conserved domains on  [gi|830869144|gb|AKL89182|]
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UDP-N-acetylmuramate--L-alanine ligase, partial [Limosilactobacillus fermentum]

Protein Classification

Mur ligase domain-containing protein( domain architecture ID 1006381)

Mur ligase domain-containing protein such as UDP-N-acetylmuramate--L-alanine ligase, which catalyzes the addition of the first amino acid to the cytoplasmic precursor of the bacterial cell wall peptidoglycan

CATH:  3.90.190.20|3.40.1190.10
Gene Ontology:  GO:0071555|GO:0005524|GO:0009252
PubMed:  28201974|17139082
SCOP:  4000154

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
MurC super family cl34041
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall ...
 1-199 1.79e-90

UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family is part of the Pathway/BioSystem: Mureine biosynthesis


The actual alignment was detected with superfamily member COG0773:

Pssm-ID: 440536 [Multi-domain]  Cd Length: 451  Bit Score: 271.94  E-value: 1.79e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830869144   1 HPDYAIMTNVDFDHPDYFKDLADVKDSFETYGRQVKKG--LFAWGEDKSLRDL--NVDVPVYYYGTAPDDDFRAANIVRT 76
Cdd:COG0773  171 SPDIAVVTNIEADHLDIYGDLEAIKEAFHEFARNVPFYglLVLCADDPGLRELlpRCGRPVITYGFSEDADYRAENIRID 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830869144  77 PDGSTYDAYYKDQKLGTFTIHLYGEHSVLNSLAVVAVAYMEKIDLEKIKAELANFSGVKRRFaEE--DIADMKVIDDYAH 154
Cdd:COG0773  251 GGGSTFDVLRRGEELGEVELNLPGRHNVLNALAAIAVALELGVDPEAIAEALASFKGVKRRF-ELkgEVGGVTVIDDYAH 329

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 830869144 155 HPSEIKATIDAARQKFPQKELVVVFQPHTYSRLAAYLTEFGQSLS 199
Cdd:COG0773  330 HPTEIAATLAAAREKYPDRRLVAVFQPHRYSRTRDFLDEFAEALS 374
 
Name Accession Description Interval E-value
MurC COG0773
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall ...
 1-199 1.79e-90

UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440536 [Multi-domain]  Cd Length: 451  Bit Score: 271.94  E-value: 1.79e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830869144   1 HPDYAIMTNVDFDHPDYFKDLADVKDSFETYGRQVKKG--LFAWGEDKSLRDL--NVDVPVYYYGTAPDDDFRAANIVRT 76
Cdd:COG0773  171 SPDIAVVTNIEADHLDIYGDLEAIKEAFHEFARNVPFYglLVLCADDPGLRELlpRCGRPVITYGFSEDADYRAENIRID 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830869144  77 PDGSTYDAYYKDQKLGTFTIHLYGEHSVLNSLAVVAVAYMEKIDLEKIKAELANFSGVKRRFaEE--DIADMKVIDDYAH 154
Cdd:COG0773  251 GGGSTFDVLRRGEELGEVELNLPGRHNVLNALAAIAVALELGVDPEAIAEALASFKGVKRRF-ELkgEVGGVTVIDDYAH 329

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 830869144 155 HPSEIKATIDAARQKFPQKELVVVFQPHTYSRLAAYLTEFGQSLS 199
Cdd:COG0773  330 HPTEIAATLAAAREKYPDRRLVAVFQPHRYSRTRDFLDEFAEALS 374
murC TIGR01082
UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial ...
 1-199 3.95e-65

UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial peptidoglycan (murein) biosynthesis. In a few species (Mycobacterium leprae, the Chlamydia), the amino acid may be L-serine or glycine instead of L-alanine. A related protein, UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase (murein tripeptide ligase) is described by model TIGR01081. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273433 [Multi-domain]  Cd Length: 448  Bit Score: 206.77  E-value: 3.95e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830869144    1 HPDYAIMTNVDFDHPD-YFKDLADVKDSFETYGRQVKKG--LFAWGEDKSLRDLNVD---VPVYYYGTAPDDDFRAANIV 74
Cdd:TIGR01082 166 QPNVAIVTNIEPDHLDtYGSSFERLKAAFEKFIHNLPFYglAVICADDPVLRELVPKateQVITYGGSGEDADYRAENIQ 245

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830869144   75 RTPDGSTYDAYYKDQKLGTFTIHLYGEHSVLNSLAVVAVAYMEKIDLEKIKAELANFSGVKRRFAE-EDIADMKVIDDYA 153
Cdd:TIGR01082 246 QSGAEGKFSVRGKGKLYLEFTLNLPGRHNVLNALAAIAVALELGIDFEAILRALANFQGVKRRFEIlGEFGGVLLIDDYA 325

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 830869144  154 HHPSEIKATIDAARQKFPQKELVVVFQPHTYSRLAAYLTEFGQSLS 199
Cdd:TIGR01082 326 HHPTEIKATLKAARQGYPDKRIVVVFQPHRYSRTRDLFDDFAKVLS 371
PRK14573 PRK14573
bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase;
1-194 5.03e-24

bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase;


Pssm-ID: 184752 [Multi-domain]  Cd Length: 809  Bit Score: 98.74  E-value: 5.03e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830869144   1 HPDYAIMTNVDFDHPDYFK-DLADVKDSFETYGRQVKKGLFAW--GEDKSLRDlnvDVPVYYYGTAPDDDFRAANIVRTP 77
Cdd:PRK14573 170 TPEFSVITNIDNEHLSNFEgDRELLLASIQDFARKVQQINKCFynGDCPRLKG---CLQGHSYGFSSSCDLHILSYYQEG 246

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830869144  78 DGSTYDAYYKDQKLGTFTIHLYGEHSVLNSLAVVAVAYMEKIDLEKIKAELANFSGVKRRFAEEDIADMKV-IDDYAHHP 156
Cdd:PRK14573 247 WRSYFSAKFLGVVYQDIELNLVGMHNVANAAAAMGIALTLGIDEGAIRNALKGFSGVQRRLERKNSSETFLfLEDYAHHP 326

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 830869144 157 SEIKATIDAARQKFPQKELVVVFQPHTYSRLAAYLTEF 194
Cdd:PRK14573 327 SEISCTLRAVRDAVGLRRIIAICQPHRFSRLRECLDSF 364
Mur_ligase_M pfam08245
Mur ligase middle domain;
2-114 1.90e-18

Mur ligase middle domain;


Pssm-ID: 462409 [Multi-domain]  Cd Length: 199  Bit Score: 79.27  E-value: 1.90e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830869144    2 PDYAIMTNVDFDHPDYFKDLADVKDSFETYGRQVKKGLFA--WGEDKSLRDL-----NVDVPVYYYGTAPDDDFRAANIV 74
Cdd:pfam08245  80 PDIAVFTNISPDHLDFHGTMENYAKAKAELFEGLPEDGIAviNADDPYGAFLiaklkKAGVRVITYGIEGEADLRAANIE 159

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 830869144   75 RTPDGSTYDAYYKDQKLGTFTIHLYGEHSVLNSLAVVAVA 114
Cdd:pfam08245 160 LSSDGTSFDLFTVPGGELEIEIPLLGRHNVYNALAAIAAA 199
 
Name Accession Description Interval E-value
MurC COG0773
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall ...
 1-199 1.79e-90

UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440536 [Multi-domain]  Cd Length: 451  Bit Score: 271.94  E-value: 1.79e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830869144   1 HPDYAIMTNVDFDHPDYFKDLADVKDSFETYGRQVKKG--LFAWGEDKSLRDL--NVDVPVYYYGTAPDDDFRAANIVRT 76
Cdd:COG0773  171 SPDIAVVTNIEADHLDIYGDLEAIKEAFHEFARNVPFYglLVLCADDPGLRELlpRCGRPVITYGFSEDADYRAENIRID 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830869144  77 PDGSTYDAYYKDQKLGTFTIHLYGEHSVLNSLAVVAVAYMEKIDLEKIKAELANFSGVKRRFaEE--DIADMKVIDDYAH 154
Cdd:COG0773  251 GGGSTFDVLRRGEELGEVELNLPGRHNVLNALAAIAVALELGVDPEAIAEALASFKGVKRRF-ELkgEVGGVTVIDDYAH 329

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 830869144 155 HPSEIKATIDAARQKFPQKELVVVFQPHTYSRLAAYLTEFGQSLS 199
Cdd:COG0773  330 HPTEIAATLAAAREKYPDRRLVAVFQPHRYSRTRDFLDEFAEALS 374
murC TIGR01082
UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial ...
 1-199 3.95e-65

UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial peptidoglycan (murein) biosynthesis. In a few species (Mycobacterium leprae, the Chlamydia), the amino acid may be L-serine or glycine instead of L-alanine. A related protein, UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase (murein tripeptide ligase) is described by model TIGR01081. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273433 [Multi-domain]  Cd Length: 448  Bit Score: 206.77  E-value: 3.95e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830869144    1 HPDYAIMTNVDFDHPD-YFKDLADVKDSFETYGRQVKKG--LFAWGEDKSLRDLNVD---VPVYYYGTAPDDDFRAANIV 74
Cdd:TIGR01082 166 QPNVAIVTNIEPDHLDtYGSSFERLKAAFEKFIHNLPFYglAVICADDPVLRELVPKateQVITYGGSGEDADYRAENIQ 245

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830869144   75 RTPDGSTYDAYYKDQKLGTFTIHLYGEHSVLNSLAVVAVAYMEKIDLEKIKAELANFSGVKRRFAE-EDIADMKVIDDYA 153
Cdd:TIGR01082 246 QSGAEGKFSVRGKGKLYLEFTLNLPGRHNVLNALAAIAVALELGIDFEAILRALANFQGVKRRFEIlGEFGGVLLIDDYA 325

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 830869144  154 HHPSEIKATIDAARQKFPQKELVVVFQPHTYSRLAAYLTEFGQSLS 199
Cdd:TIGR01082 326 HHPTEIKATLKAARQGYPDKRIVVVFQPHRYSRTRDLFDDFAKVLS 371
MurE COG0769
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; ...
 3-179 3.01e-29

UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl tripeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440532 [Multi-domain]  Cd Length: 459  Bit Score: 112.48  E-value: 3.01e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830869144   3 DYAIMTNVDFDHPDYFKDladvkdsFETYgRQVKKGLFAWGEDKSLRDLNVD------------VPVYYYGTAPDDDFRA 70
Cdd:COG0769  171 DVAVFTNLTRDHLDYHGT-------MEAY-FAAKARLFDQLGPGGAAVINADdpygrrlaaaapARVITYGLKADADLRA 242

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830869144  71 ANIVRTPDGSTYDAYYKDQKlGTFTIHLYGEHSVLNSLAVVAVAYMEKIDLEKIKAELANFSGVKRRF----AEEDIadm 146
Cdd:COG0769  243 TDIELSADGTRFTLVTPGGE-VEVRLPLIGRFNVYNALAAIAAALALGIDLEEILAALEKLKGVPGRMervdGGQGP--- 318

                        170       180       190
                 ....*....|....*....|....*....|...
gi 830869144 147 KVIDDYAHHPSEIKATIDAARQkFPQKELVVVF 179
Cdd:COG0769  319 TVIVDYAHTPDALENVLEALRP-HTKGRLIVVF 350
PRK14573 PRK14573
bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase;
1-194 5.03e-24

bifunctional UDP-N-acetylmuramate--L-alanine ligase/D-alanine--D-alanine ligase;


Pssm-ID: 184752 [Multi-domain]  Cd Length: 809  Bit Score: 98.74  E-value: 5.03e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830869144   1 HPDYAIMTNVDFDHPDYFK-DLADVKDSFETYGRQVKKGLFAW--GEDKSLRDlnvDVPVYYYGTAPDDDFRAANIVRTP 77
Cdd:PRK14573 170 TPEFSVITNIDNEHLSNFEgDRELLLASIQDFARKVQQINKCFynGDCPRLKG---CLQGHSYGFSSSCDLHILSYYQEG 246

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830869144  78 DGSTYDAYYKDQKLGTFTIHLYGEHSVLNSLAVVAVAYMEKIDLEKIKAELANFSGVKRRFAEEDIADMKV-IDDYAHHP 156
Cdd:PRK14573 247 WRSYFSAKFLGVVYQDIELNLVGMHNVANAAAAMGIALTLGIDEGAIRNALKGFSGVQRRLERKNSSETFLfLEDYAHHP 326

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 830869144 157 SEIKATIDAARQKFPQKELVVVFQPHTYSRLAAYLTEF 194
Cdd:PRK14573 327 SEISCTLRAVRDAVGLRRIIAICQPHRFSRLRECLDSF 364
MurF COG0770
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; ...
 2-151 4.98e-21

UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440533 [Multi-domain]  Cd Length: 451  Bit Score: 89.39  E-value: 4.98e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830869144   2 PDYAIMTNVDFDHPDYFKDLADVkdsFETYG---RQVKKGLFAW--GEDKSLRDL--NVDVPVYYYGTAPDDDFRAANIV 74
Cdd:COG0770  176 PDIAVITNIGPAHLEGFGSLEGI---ARAKGeifEGLPPGGVAVlnADDPLLAALaeRAKARVLTFGLSEDADVRAEDIE 252

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 830869144  75 RTPDGSTYDAYYKDQKLgTFTIHLYGEHSVLNSLAVVAVAYMEKIDLEKIKAELANFSGVKRRFAEEDIAD-MKVIDD 151
Cdd:COG0770  253 LDEDGTRFTLHTPGGEL-EVTLPLPGRHNVSNALAAAAVALALGLDLEEIAAGLAAFQPVKGRLEVIEGAGgVTLIDD 329
murE PRK00139
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional
 5-179 1.40e-18

UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional


Pssm-ID: 234660 [Multi-domain]  Cd Length: 460  Bit Score: 82.49  E-value: 1.40e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830869144   5 AIMTNVDFDHPDYFKDladvkdsFETYgRQVKKGLFAWGEDKSLrdLNVD---------VPVYYYGTAPDDDFRAANIVR 75
Cdd:PRK00139 188 AVFTNLSRDHLDYHGT-------MEDY-LAAKARLFSELGLAAV--INADdevgrrllaLPDAYAVSMAGADLRATDVEY 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830869144  76 TPDGSTYDAYYkdqklgTFTIHLYGEHSVLNSLAVVAVAYMEKIDLEKIKAELANFSGVK-R--RFAEEDiaDMKVIDDY 152
Cdd:PRK00139 258 TDSGQTFTLVT------EVESPLIGRFNVSNLLAALAALLALGVPLEDALAALAKLQGVPgRmeRVDAGQ--GPLVIVDY 329

                        170       180
                 ....*....|....*....|....*..
gi 830869144 153 AHHPSEIKATIDAARQkFPQKELVVVF 179
Cdd:PRK00139 330 AHTPDALEKVLEALRP-HAKGRLICVF 355
Mur_ligase_M pfam08245
Mur ligase middle domain;
2-114 1.90e-18

Mur ligase middle domain;


Pssm-ID: 462409 [Multi-domain]  Cd Length: 199  Bit Score: 79.27  E-value: 1.90e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830869144    2 PDYAIMTNVDFDHPDYFKDLADVKDSFETYGRQVKKGLFA--WGEDKSLRDL-----NVDVPVYYYGTAPDDDFRAANIV 74
Cdd:pfam08245  80 PDIAVFTNISPDHLDFHGTMENYAKAKAELFEGLPEDGIAviNADDPYGAFLiaklkKAGVRVITYGIEGEADLRAANIE 159

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 830869144   75 RTPDGSTYDAYYKDQKLGTFTIHLYGEHSVLNSLAVVAVA 114
Cdd:pfam08245 160 LSSDGTSFDLFTVPGGELEIEIPLLGRHNVYNALAAIAAA 199
PRK11929 PRK11929
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ...
 5-179 4.36e-15

bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;


Pssm-ID: 237025 [Multi-domain]  Cd Length: 958  Bit Score: 72.81  E-value: 4.36e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830869144   5 AIMTNVDFDHPDYFKDLADvkdsfetYgRQVKKGLF-AWGED-------------KSLRDLNVDVPVYYYGTAPDDDFRA 70
Cdd:PRK11929 205 AGFTNLTRDHLDYHGTMQD-------Y-EEAKAALFsKLPGLgaavinaddpaaaRLLAALPRGLKVGYSPQNAGADVQA 276

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830869144  71 ANIVRTPDGSTYDAYYKDQKLgTFTIHLYGEHSVLNSLAVVAVAYMEKIDLEKIKAELANFSGVKRRF----AEEDIADM 146
Cdd:PRK11929 277 RDLRATAHGQVFTLATPDGSY-QLVTRLLGRFNVSNLLLVAAALKKLGLPLAQIARALAAVSPVPGRMervgPTAGAQGP 355

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 830869144 147 KVIDDYAHHPSEIKATIDAAR--QKFPQKELVVVF 179
Cdd:PRK11929 356 LVVVDYAHTPDALAKALTALRpvAQARNGRLVCVF 390
murE TIGR01085
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, ...
 3-179 5.34e-14

UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. An exception is Staphylococcus aureus, in which diaminopimelate is replaced by lysine in the peptidoglycan and MurE is EC 6.3.2.7. The Mycobacteria, part of the closest neighboring branch outside of the low-GC Gram-positive bacteria, use diaminopimelate. A close homolog, scoring just below the trusted cutoff, is found (with introns) in Arabidopsis thaliana. Its role is unknown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273435 [Multi-domain]  Cd Length: 464  Bit Score: 69.65  E-value: 5.34e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830869144    3 DYAIMTNVDFDHPDYFKdladvkdSFETYgRQVKKGLFAWGEDKSLRDLNVDVP--VYYYGTAPDD-------------- 66
Cdd:TIGR01085 179 DAAVFTNLSRDHLDFHG-------TMENY-FAAKASLFTELGLKRFAVINLDDEygAQFVKRLPKDitvsaitqpadgra 250

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830869144   67 -DFRAANIVRTPDGSTYDAYYKDQkLGTFTIHLYGEHSVLNSLAVVAVA-YMEKIDLEKIKAELANFSGVKRRFAEEDIA 144
Cdd:TIGR01085 251 qDIKITDSGYSFEGQQFTFETPAG-EGHLHTPLIGRFNVYNLLAALATLlHLGGIDLEDIVAALEKFRGVPGRMELVDGG 329

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 830869144  145 -DMKVIDDYAHHPSEIKATIDAARqKFPQKELVVVF 179
Cdd:TIGR01085 330 qKFLVIVDYAHTPDALEKALRTLR-KHKDGRLIVVF 364
MurD COG0771
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ...
 1-166 2.04e-09

UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440534 [Multi-domain]  Cd Length: 445  Bit Score: 55.86  E-value: 2.04e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830869144   1 HPDYAIMTNVDFDHPDYFKdladvkdSFETYgRQVKKGLFAWGEDKslrdlnvDVPVYYYgtapdDDFRAANIVRTPDGS 80
Cdd:COG0771  173 RPDVAVILNITPDHLDRHG-------SMEAY-AAAKARIFANQTPD-------DYAVLNA-----DDPLTRALAEEAKAR 232

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830869144  81 TY----------DAYYKDQKL-----GTFT-----IHLYGEHSVLNSLAVVAVAYMEKIDLEKIKAELANFSGVKRRF-- 138
Cdd:COG0771  233 VVpfslkeplegGAGLEDGKLvdrasGEELlpvddLRLPGRHNLENALAALAAARALGVPPEAIREALRSFKGLPHRLef 312

                        170       180       190
                 ....*....|....*....|....*....|
gi 830869144 139 -AEedIADMKVIDDyahhpSeiKAT-IDAA 166
Cdd:COG0771  313 vAE--INGVRFIND-----S--KATnPDAT 333
Mur_ligase_C pfam02875
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase ...
 148-199 1.02e-08

Mur ligase family, glutamate ligase domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.


Pssm-ID: 460731 [Multi-domain]  Cd Length: 87  Bit Score: 50.42  E-value: 1.02e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 830869144  148 VIDDYAHHPSEIKATIDAARQKFPQKeLVVVFQPHTySRLAAYLTEFGQSLS 199
Cdd:pfam02875  16 VIDDYAHNPDAMEAALRALRNLFPGR-LILVFGGMG-DRDAEFHALLGRLAA 65
PRK11929 PRK11929
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ...
 2-177 1.13e-04

bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;


Pssm-ID: 237025 [Multi-domain]  Cd Length: 958  Bit Score: 42.38  E-value: 1.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830869144   2 PDYAIMTNVDFDHPDYFKDLADVKdsfetygrQVKKGLFAWGEDKSLRDLNVDVP-------------VYYYGTAPDDDF 68
Cdd:PRK11929 682 PTVALVTNAQREHQEFMHSVEAVA--------RAKGEIIAALPEDGVAVVNGDDPytaiwaklagarrVLRFGLQPGADV 753

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830869144  69 RAANIVRtpDGSTYDAYYKDQKLGT------FTIHLYGEHSVLNSLAVVAVAYMEKIDLEKIKAELANFSGVKRRFAEED 142
Cdd:PRK11929 754 YAEKIAK--DISVGEAGGTRCQVVTpagsaeVYLPLIGEHNLRNALAAIACALAAGASLKQIRAGLERFQPVAGRMQRRR 831

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 830869144 143 IAD-MKVIDD-YAHHPSEIKATIDA-ARQKFPQKELVV 177
Cdd:PRK11929 832 LSCgTRIIDDtYNANPDSMRAAIDVlAELPNGPRALVL 869
PRK14093 PRK14093
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; ...
 2-121 1.88e-04

UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional


Pssm-ID: 184501 [Multi-domain]  Cd Length: 479  Bit Score: 41.30  E-value: 1.88e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830869144   2 PDYAIMTNVDFDHPDYFKDLADVKDSfetygrqvKKGLFAWGEDKSLRDLNVDVPVY----------------YYGTAPD 65
Cdd:PRK14093 184 PHVAIITTVEPVHLEFFSGIEAIADA--------KAEIFTGLEPGGAAVLNRDNPQFdrlaasaraagiarivSFGADEK 255

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 830869144  66 DDFRAANIVRTPDGSTYDAYYKDQKLgTFTIHLYGEHSVLNSLAVVAVAYMEKIDL 121
Cdd:PRK14093 256 ADARLLDVALHADCSAVHADILGHDV-TYKLGMPGRHIAMNSLAVLAAAELAGADL 310
murD PRK14106
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional
 1-137 4.19e-03

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional


Pssm-ID: 184511 [Multi-domain]  Cd Length: 450  Bit Score: 37.26  E-value: 4.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 830869144   1 HPDYAIMTNVDFDHPDYFKdladvkdSFETYgRQVKKGLFA-----------WgEDKSLRDLNVDVP--VYYY------- 60
Cdd:PRK14106 176 KPKVGCILNITPDHLDRHK-------TMENY-IKAKARIFEnqrpsdytvlnY-DDPRTRSLAKKAKarVIFFsrkslle 246

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 830869144  61 -GTAPDDDFraanIVRTPDGSTYDAYYKDqklgtfTIHLYGEHSVLNSLAVVAVAYMEKIDLEKIKAELANFSGVKRR 137
Cdd:PRK14106 247 eGVFVKNGK----IVISLGGKEEEVIDID------EIFIPGEHNLENALAATAAAYLLGISPDVIANTLKTFKGVEHR 314
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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