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Conserved domains on  [gi|827402719|gb|AKJ42879|]
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cysteine synthase [Pragia fontium]

Protein Classification

cysteine synthase A( domain architecture ID 10795719)

cysteine synthase A (CysK/CysB/CysE) catalyzes the conversion of O-succinyl-L-serine/O-acetyl-L-serine into cysteine, the last step in the cysteine biosynthesis pathway

EC:  2.5.1.47
Gene Ontology:  GO:0019344|GO:0004124|GO:0030170

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
cysK TIGR01139
cysteine synthase A; This model distinguishes cysteine synthase A (CysK) from cysteine ...
 8-311 3.77e-180

cysteine synthase A; This model distinguishes cysteine synthase A (CysK) from cysteine synthase B (CysM). CysM differs in having a broader specificity that also allows the use of thiosulfate to produce cysteine thiosulfonate. [Amino acid biosynthesis, Serine family]


:

Pssm-ID: 273465  Cd Length: 298  Bit Score: 499.20  E-value: 3.77e-180
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719    8 NSQTIGHTPLVRLNRI--GNGRILAKVESRNPSFSVKCRIGANMIWDAEKRGVLKKGVQIVEPTSGNTGIALAFVAAARG 85
Cdd:TIGR01139   1 ISELIGNTPLVRLNRIegCNANVFVKLEGRNPSGSVKDRIALNMIWDAEKRGLLKPGKTIVEPTSGNTGIALAMVAAARG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719   86 YKLTLTMPESMSLERRKLLKALGANLVLTEAAKGMKGAIAKAEEIVAADPQRNLLLQQFNNPANPEIHEKTTGPEIWQDT 165
Cdd:TIGR01139  81 YKLILTMPETMSIERRKLLKAYGAELVLTPGAEGMKGAIAKAEEIAASTPNSYFMLQQFENPANPEIHRKTTGPEIWRDT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719  166 DGEIDVFIAGVGTGGTLTGVSRYIKNTKGkKIISVAVEPTDSPVISQAlageelKPGPHKIQGIGAGFIPGNLDLSLIDR 245
Cdd:TIGR01139 161 DGKLDAFVAGVGTGGTITGVGEVLKEQKP-NIKIVAVEPAESPVLSGG------KPGPHKIQGIGAGFIPKNLNRSVIDE 233

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 827402719  246 VEKITNEEAISTARRLMEEEGILAGISSGAAVAAALKLIELPEfADKNIVVILPSSGERYLSTPLF 311
Cdd:TIGR01139 234 VITVSDEEAIETARRLAAEEGILVGISSGAAVAAALKLAKRPE-PDKLIVVILPSTGERYLSTPLF 298
 
Name Accession Description Interval E-value
cysK TIGR01139
cysteine synthase A; This model distinguishes cysteine synthase A (CysK) from cysteine ...
 8-311 3.77e-180

cysteine synthase A; This model distinguishes cysteine synthase A (CysK) from cysteine synthase B (CysM). CysM differs in having a broader specificity that also allows the use of thiosulfate to produce cysteine thiosulfonate. [Amino acid biosynthesis, Serine family]


Pssm-ID: 273465  Cd Length: 298  Bit Score: 499.20  E-value: 3.77e-180
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719    8 NSQTIGHTPLVRLNRI--GNGRILAKVESRNPSFSVKCRIGANMIWDAEKRGVLKKGVQIVEPTSGNTGIALAFVAAARG 85
Cdd:TIGR01139   1 ISELIGNTPLVRLNRIegCNANVFVKLEGRNPSGSVKDRIALNMIWDAEKRGLLKPGKTIVEPTSGNTGIALAMVAAARG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719   86 YKLTLTMPESMSLERRKLLKALGANLVLTEAAKGMKGAIAKAEEIVAADPQRNLLLQQFNNPANPEIHEKTTGPEIWQDT 165
Cdd:TIGR01139  81 YKLILTMPETMSIERRKLLKAYGAELVLTPGAEGMKGAIAKAEEIAASTPNSYFMLQQFENPANPEIHRKTTGPEIWRDT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719  166 DGEIDVFIAGVGTGGTLTGVSRYIKNTKGkKIISVAVEPTDSPVISQAlageelKPGPHKIQGIGAGFIPGNLDLSLIDR 245
Cdd:TIGR01139 161 DGKLDAFVAGVGTGGTITGVGEVLKEQKP-NIKIVAVEPAESPVLSGG------KPGPHKIQGIGAGFIPKNLNRSVIDE 233

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 827402719  246 VEKITNEEAISTARRLMEEEGILAGISSGAAVAAALKLIELPEfADKNIVVILPSSGERYLSTPLF 311
Cdd:TIGR01139 234 VITVSDEEAIETARRLAAEEGILVGISSGAAVAAALKLAKRPE-PDKLIVVILPSTGERYLSTPLF 298
CysK COG0031
Cysteine synthase [Amino acid transport and metabolism]; Cysteine synthase is part of the ...
 3-308 6.05e-161

Cysteine synthase [Amino acid transport and metabolism]; Cysteine synthase is part of the Pathway/BioSystem: Cysteine biosynthesis


Pssm-ID: 439802 [Multi-domain]  Cd Length: 301  Bit Score: 450.65  E-value: 6.05e-161
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719   3 KIYEDNSQTIGHTPLVRLNRIGNG---RILAKVESRNPSFSVKCRIGANMIWDAEKRGVLKKGVQIVEPTSGNTGIALAF 79
Cdd:COG0031    2 RIYDSILELIGNTPLVRLNRLSPGpgaEIYAKLESFNPGGSVKDRIALSMIEDAEKRGLLKPGGTIVEATSGNTGIGLAM 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719  80 VAAARGYKLTLTMPESMSLERRKLLKALGANLVLTEAAKGMKGAIAKAEEIVAADPqRNLLLQQFNNPANPEIHEKTTGP 159
Cdd:COG0031   82 VAAAKGYRLILVMPETMSKERRALLRAYGAEVVLTPGAEGMKGAIDKAEELAAETP-GAFWPNQFENPANPEAHYETTGP 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719 160 EIWQDTDGEIDVFIAgvgtggtltgvSRYIKNtKGKKIISVAVEPTDSPVISQAlageelKPGPHKIQGIGAGFIPGNLD 239
Cdd:COG0031  161 EIWEQTDGKVDAFVAgvgtggtitgvGRYLKE-RNPDIKIVAVEPEGSPLLSGG------EPGPHKIEGIGAGFVPKILD 233

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719 240 LSLIDRVEKITNEEAISTARRLMEEEGILAGISSGAAVAAALKLI-ELPEfaDKNIVVILPSSGERYLST 308
Cdd:COG0031  234 PSLIDEVITVSDEEAFAMARRLAREEGILVGISSGAAVAAALRLAkRLGP--GKTIVTILPDSGERYLST 301
PRK10717 PRK10717
cysteine synthase A; Provisional
 2-322 5.77e-160

cysteine synthase A; Provisional


Pssm-ID: 182672 [Multi-domain]  Cd Length: 330  Bit Score: 449.70  E-value: 5.77e-160
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719   2 TKIYEDNSQTIGHTPLVRLNRIGN---GRILAKVESRNPSFSVKCRIGANMIWDAEKRGVLKKGVQIVEPTSGNTGIALA 78
Cdd:PRK10717   1 MKIFEDVSDTIGNTPLIRLNRASEatgCEILGKAEFLNPGGSVKDRAALNIIWDAEKRGLLKPGGTIVEGTAGNTGIGLA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719  79 FVAAARGYKLTLTMPESMSLERRKLLKALGANLVLTEAA------KGMKGAIAKAEEIVAADPQRNLLLQQFNNPANPEI 152
Cdd:PRK10717  81 LVAAARGYKTVIVMPETQSQEKKDLLRALGAELVLVPAApyanpnNYVKGAGRLAEELVASEPNGAIWANQFDNPANREA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719 153 HEKTTGPEIWQDTDGEIDVFIAGVGTGGTLTGVSRYIKNTKGKKIIsVAVEPTDSPVISQALAGEELKPGPHKIQGIGAG 232
Cdd:PRK10717 161 HYETTGPEIWEQTDGKVDGFVCAVGTGGTLAGVSRYLKETNPKVKI-VLADPTGSALYSYYKTGELKAEGSSITEGIGQG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719 233 FIPGNLDLSLIDRVEKITNEEAISTARRLMEEEGILAGISSGAAVAAALKLIElPEFADKNIVVILPSSGERYLSTPLFA 312
Cdd:PRK10717 240 RITANLEGAPIDDAIRIPDEEALSTAYRLLEEEGLCLGGSSGINVAAALRLAR-ELGPGHTIVTILCDSGERYQSKLFNP 318

                        330
                 ....*....|
gi 827402719 313 DLFTEKELQQ 322
Cdd:PRK10717 319 DFLREKGLPV 328
CBS_like cd01561
CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS ...
 13-307 5.60e-141

CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. Deficiency of CBS leads to homocystinuria, an inherited disease of sulfur metabolism characterized by increased levels of the toxic metabolite homocysteine. Cysteine synthase on the other hand catalyzes the last step of cysteine biosynthesis. This subgroup also includes an O-Phosphoserine sulfhydrylase found in hyperthermophilic archaea which produces L-cysteine from sulfide and the more thermostable O-phospho-L-serine.


Pssm-ID: 107204 [Multi-domain]  Cd Length: 291  Bit Score: 399.97  E-value: 5.60e-141
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719  13 GHTPLVRLNRIGNG---RILAKVESRNPSFSVKCRIGANMIWDAEKRGVLKKGVQIVEPTSGNTGIALAFVAAARGYKLT 89
Cdd:cd01561    1 GNTPLVRLNRLSPGtgaEIYAKLEFFNPGGSVKDRIALYMIEDAEKRGLLKPGTTIIEPTSGNTGIGLAMVAAAKGYRFI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719  90 LTMPESMSLERRKLLKALGANLVLTEAAK--GMKGAIAKAEEIVAADPqRNLLLQQFNNPANPEIHEKTTGPEIWQDTDG 167
Cdd:cd01561   81 IVMPETMSEEKRKLLRALGAEVILTPEAEadGMKGAIAKARELAAETP-NAFWLNQFENPANPEAHYETTAPEIWEQLDG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719 168 EIDVFIAGVGTGGTLTGVSRYIKNtKGKKIISVAVEPTDSPVISQalageeLKPGPHKIQGIGAGFIPGNLDLSLIDRVE 247
Cdd:cd01561  160 KVDAFVAGVGTGGTITGVARYLKE-KNPNVRIVGVDPVGSVLFSG------GPPGPHKIEGIGAGFIPENLDRSLIDEVV 232

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719 248 KITNEEAISTARRLMEEEGILAGISSGAAVAAALKLIELPEfADKNIVVILPSSGERYLS 307
Cdd:cd01561  233 RVSDEEAFAMARRLAREEGLLVGGSSGAAVAAALKLAKRLG-PGKTIVTILPDSGERYLS 291
PALP pfam00291
Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate ...
 9-299 2.39e-67

Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate dependent enzymes. This family includes: serine dehydratase EC:4.2.1.13 P20132, threonine dehydratase EC:4.2.1.16, tryptophan synthase beta chain EC:4.2.1.20, threonine synthase EC:4.2.99.2, cysteine synthase EC:4.2.99.8 P11096, cystathionine beta-synthase EC:4.2.1.22, 1-aminocyclopropane-1-carboxylate deaminase EC:4.1.99.4.


Pssm-ID: 459749 [Multi-domain]  Cd Length: 295  Bit Score: 212.56  E-value: 2.39e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719    9 SQTIGHTPLVRLNRIG---NGRILAKVESRNPSFSVKCRIGANMIWDAEKRgvlKKGVQIVEPTSGNTGIALAFVAAARG 85
Cdd:pfam00291   2 SLGIGPTPLVRLPRLSkelGVDVYLKLESLNPTGSFKDRGALNLLLRLKEG---EGGKTVVEASSGNHGRALAAAAARLG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719   86 YKLTLTMPESMSLERRKLLKALGANLVLTEAakGMKGAIAKAEEIvAADPQRNLLLQQFNNPANPEIHeKTTGPEIWQDT 165
Cdd:pfam00291  79 LKVTIVVPEDAPPGKLLLMRALGAEVVLVGG--DYDEAVAAAREL-AAEGPGAYYINQYDNPLNIEGY-GTIGLEILEQL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719  166 DGEIDVFIAGVGTGGTLTGVSRYIKNTKGK-KIIsvAVEPTDSPVISQALAG---EELKPGPHKIQGIGAGFIPGNLDLS 241
Cdd:pfam00291 155 GGDPDAVVVPVGGGGLIAGIARGLKELGPDvRVI--GVEPEGAPALARSLAAgrpVPVPVADTIADGLGVGDEPGALALD 232

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 827402719  242 LIDR----VEKITNEEAISTARRLMEEEGILAGISSGAAVaAALKLIELPEF-ADKNIVVILP 299
Cdd:pfam00291 233 LLDEyvgeVVTVSDEEALEAMRLLARREGIVVEPSSAAAL-AALKLALAGELkGGDRVVVVLT 294
 
Name Accession Description Interval E-value
cysK TIGR01139
cysteine synthase A; This model distinguishes cysteine synthase A (CysK) from cysteine ...
 8-311 3.77e-180

cysteine synthase A; This model distinguishes cysteine synthase A (CysK) from cysteine synthase B (CysM). CysM differs in having a broader specificity that also allows the use of thiosulfate to produce cysteine thiosulfonate. [Amino acid biosynthesis, Serine family]


Pssm-ID: 273465  Cd Length: 298  Bit Score: 499.20  E-value: 3.77e-180
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719    8 NSQTIGHTPLVRLNRI--GNGRILAKVESRNPSFSVKCRIGANMIWDAEKRGVLKKGVQIVEPTSGNTGIALAFVAAARG 85
Cdd:TIGR01139   1 ISELIGNTPLVRLNRIegCNANVFVKLEGRNPSGSVKDRIALNMIWDAEKRGLLKPGKTIVEPTSGNTGIALAMVAAARG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719   86 YKLTLTMPESMSLERRKLLKALGANLVLTEAAKGMKGAIAKAEEIVAADPQRNLLLQQFNNPANPEIHEKTTGPEIWQDT 165
Cdd:TIGR01139  81 YKLILTMPETMSIERRKLLKAYGAELVLTPGAEGMKGAIAKAEEIAASTPNSYFMLQQFENPANPEIHRKTTGPEIWRDT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719  166 DGEIDVFIAGVGTGGTLTGVSRYIKNTKGkKIISVAVEPTDSPVISQAlageelKPGPHKIQGIGAGFIPGNLDLSLIDR 245
Cdd:TIGR01139 161 DGKLDAFVAGVGTGGTITGVGEVLKEQKP-NIKIVAVEPAESPVLSGG------KPGPHKIQGIGAGFIPKNLNRSVIDE 233

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 827402719  246 VEKITNEEAISTARRLMEEEGILAGISSGAAVAAALKLIELPEfADKNIVVILPSSGERYLSTPLF 311
Cdd:TIGR01139 234 VITVSDEEAIETARRLAAEEGILVGISSGAAVAAALKLAKRPE-PDKLIVVILPSTGERYLSTPLF 298
cysKM TIGR01136
cysteine synthase; This model discriminates cysteine synthases (EC 2.5.1.47) (both CysK and ...
 8-311 7.43e-169

cysteine synthase; This model discriminates cysteine synthases (EC 2.5.1.47) (both CysK and CysM) from cystathionine beta-synthase, a protein found primarily in eukaryotes and carrying a C-terminal CBS domain lacking from this protein. Bacterial proteins lacking the CBS domain but otherwise showing resemblamnce to cystathionine beta-synthases and considerable phylogenetic distance from known cysteine synthases were excluded from the seed and score below the trusted cutoff. [Amino acid biosynthesis, Serine family]


Pssm-ID: 273463  Cd Length: 299  Bit Score: 471.00  E-value: 7.43e-169
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719    8 NSQTIGHTPLVRLNRIG---NGRILAKVESRNPSFSVKCRIGANMIWDAEKRGVLKKGVQIVEPTSGNTGIALAFVAAAR 84
Cdd:TIGR01136   1 IEELIGNTPLVRLNRLApgcDARVLAKLEGFNPSGSVKDRIALSMILDAEKRGLLKPGDTIIEATSGNTGIALAMVAAAR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719   85 GYKLTLTMPESMSLERRKLLKALGANLVLTEAAKGMKGAIAKAEEIVAADPqRNLLLQQFNNPANPEIHEKTTGPEIWQD 164
Cdd:TIGR01136  81 GYKLILTMPETMSLERRKLLRAYGAELILTPGEEGMKGAIDKAEELAAETN-KYVMLDQFENPANPEAHYKTTGPEIWRD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719  165 TDGEIDVFIAGVGTGGTLTGVSRYIKNTKGkKIISVAVEPTDSPVISQAlageelKPGPHKIQGIGAGFIPGNLDLSLID 244
Cdd:TIGR01136 160 TDGRIDHFVAGVGTGGTITGVGRYLKEQNP-NIQIVAVEPAESPVLSGG------EPGPHKIQGIGAGFIPKILDLSLID 232

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 827402719  245 RVEKITNEEAISTARRLMEEEGILAGISSGAAVAAALKLIELPEFADKNIVVILPSSGERYLSTPLF 311
Cdd:TIGR01136 233 EVITVSDEDAIETARRLAREEGILVGISSGAAVAAALKLAKRLENADKVIVAILPDTGERYLSTGLF 299
CysK COG0031
Cysteine synthase [Amino acid transport and metabolism]; Cysteine synthase is part of the ...
 3-308 6.05e-161

Cysteine synthase [Amino acid transport and metabolism]; Cysteine synthase is part of the Pathway/BioSystem: Cysteine biosynthesis


Pssm-ID: 439802 [Multi-domain]  Cd Length: 301  Bit Score: 450.65  E-value: 6.05e-161
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719   3 KIYEDNSQTIGHTPLVRLNRIGNG---RILAKVESRNPSFSVKCRIGANMIWDAEKRGVLKKGVQIVEPTSGNTGIALAF 79
Cdd:COG0031    2 RIYDSILELIGNTPLVRLNRLSPGpgaEIYAKLESFNPGGSVKDRIALSMIEDAEKRGLLKPGGTIVEATSGNTGIGLAM 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719  80 VAAARGYKLTLTMPESMSLERRKLLKALGANLVLTEAAKGMKGAIAKAEEIVAADPqRNLLLQQFNNPANPEIHEKTTGP 159
Cdd:COG0031   82 VAAAKGYRLILVMPETMSKERRALLRAYGAEVVLTPGAEGMKGAIDKAEELAAETP-GAFWPNQFENPANPEAHYETTGP 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719 160 EIWQDTDGEIDVFIAgvgtggtltgvSRYIKNtKGKKIISVAVEPTDSPVISQAlageelKPGPHKIQGIGAGFIPGNLD 239
Cdd:COG0031  161 EIWEQTDGKVDAFVAgvgtggtitgvGRYLKE-RNPDIKIVAVEPEGSPLLSGG------EPGPHKIEGIGAGFVPKILD 233

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719 240 LSLIDRVEKITNEEAISTARRLMEEEGILAGISSGAAVAAALKLI-ELPEfaDKNIVVILPSSGERYLST 308
Cdd:COG0031  234 PSLIDEVITVSDEEAFAMARRLAREEGILVGISSGAAVAAALRLAkRLGP--GKTIVTILPDSGERYLST 301
PRK10717 PRK10717
cysteine synthase A; Provisional
 2-322 5.77e-160

cysteine synthase A; Provisional


Pssm-ID: 182672 [Multi-domain]  Cd Length: 330  Bit Score: 449.70  E-value: 5.77e-160
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719   2 TKIYEDNSQTIGHTPLVRLNRIGN---GRILAKVESRNPSFSVKCRIGANMIWDAEKRGVLKKGVQIVEPTSGNTGIALA 78
Cdd:PRK10717   1 MKIFEDVSDTIGNTPLIRLNRASEatgCEILGKAEFLNPGGSVKDRAALNIIWDAEKRGLLKPGGTIVEGTAGNTGIGLA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719  79 FVAAARGYKLTLTMPESMSLERRKLLKALGANLVLTEAA------KGMKGAIAKAEEIVAADPQRNLLLQQFNNPANPEI 152
Cdd:PRK10717  81 LVAAARGYKTVIVMPETQSQEKKDLLRALGAELVLVPAApyanpnNYVKGAGRLAEELVASEPNGAIWANQFDNPANREA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719 153 HEKTTGPEIWQDTDGEIDVFIAGVGTGGTLTGVSRYIKNTKGKKIIsVAVEPTDSPVISQALAGEELKPGPHKIQGIGAG 232
Cdd:PRK10717 161 HYETTGPEIWEQTDGKVDGFVCAVGTGGTLAGVSRYLKETNPKVKI-VLADPTGSALYSYYKTGELKAEGSSITEGIGQG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719 233 FIPGNLDLSLIDRVEKITNEEAISTARRLMEEEGILAGISSGAAVAAALKLIElPEFADKNIVVILPSSGERYLSTPLFA 312
Cdd:PRK10717 240 RITANLEGAPIDDAIRIPDEEALSTAYRLLEEEGLCLGGSSGINVAAALRLAR-ELGPGHTIVTILCDSGERYQSKLFNP 318

                        330
                 ....*....|
gi 827402719 313 DLFTEKELQQ 322
Cdd:PRK10717 319 DFLREKGLPV 328
CBS_like cd01561
CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS ...
 13-307 5.60e-141

CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. Deficiency of CBS leads to homocystinuria, an inherited disease of sulfur metabolism characterized by increased levels of the toxic metabolite homocysteine. Cysteine synthase on the other hand catalyzes the last step of cysteine biosynthesis. This subgroup also includes an O-Phosphoserine sulfhydrylase found in hyperthermophilic archaea which produces L-cysteine from sulfide and the more thermostable O-phospho-L-serine.


Pssm-ID: 107204 [Multi-domain]  Cd Length: 291  Bit Score: 399.97  E-value: 5.60e-141
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719  13 GHTPLVRLNRIGNG---RILAKVESRNPSFSVKCRIGANMIWDAEKRGVLKKGVQIVEPTSGNTGIALAFVAAARGYKLT 89
Cdd:cd01561    1 GNTPLVRLNRLSPGtgaEIYAKLEFFNPGGSVKDRIALYMIEDAEKRGLLKPGTTIIEPTSGNTGIGLAMVAAAKGYRFI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719  90 LTMPESMSLERRKLLKALGANLVLTEAAK--GMKGAIAKAEEIVAADPqRNLLLQQFNNPANPEIHEKTTGPEIWQDTDG 167
Cdd:cd01561   81 IVMPETMSEEKRKLLRALGAEVILTPEAEadGMKGAIAKARELAAETP-NAFWLNQFENPANPEAHYETTAPEIWEQLDG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719 168 EIDVFIAGVGTGGTLTGVSRYIKNtKGKKIISVAVEPTDSPVISQalageeLKPGPHKIQGIGAGFIPGNLDLSLIDRVE 247
Cdd:cd01561  160 KVDAFVAGVGTGGTITGVARYLKE-KNPNVRIVGVDPVGSVLFSG------GPPGPHKIEGIGAGFIPENLDRSLIDEVV 232

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719 248 KITNEEAISTARRLMEEEGILAGISSGAAVAAALKLIELPEfADKNIVVILPSSGERYLS 307
Cdd:cd01561  233 RVSDEEAFAMARRLAREEGLLVGGSSGAAVAAALKLAKRLG-PGKTIVTILPDSGERYLS 291
PLN02565 PLN02565
cysteine synthase
 4-319 9.15e-118

cysteine synthase


Pssm-ID: 166206  Cd Length: 322  Bit Score: 342.29  E-value: 9.15e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719   4 IYEDNSQTIGHTPLVRLNRIGNG---RILAKVESRNPSFSVKCRIGANMIWDAEKRGVLKKGVQI-VEPTSGNTGIALAF 79
Cdd:PLN02565   5 IAKDVTELIGKTPLVYLNNVVDGcvaRIAAKLEMMEPCSSVKDRIGYSMITDAEEKGLIKPGESVlIEPTSGNTGIGLAF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719  80 VAAARGYKLTLTMPESMSLERRKLLKALGANLVLTEAAKGMKGAIAKAEEIVAADPQrNLLLQQFNNPANPEIHEKTTGP 159
Cdd:PLN02565  85 MAAAKGYKLIITMPASMSLERRIILLAFGAELVLTDPAKGMKGAVQKAEEILAKTPN-SYILQQFENPANPKIHYETTGP 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719 160 EIWQDTDGEIDVFIAGVGTGGTLTGVSRYIKNtKGKKIISVAVEPTDSPVISQAlageelKPGPHKIQGIGAGFIPGNLD 239
Cdd:PLN02565 164 EIWKGTGGKVDAFVSGIGTGGTITGAGKYLKE-QNPDIKLYGVEPVESAVLSGG------KPGPHKIQGIGAGFIPGVLD 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719 240 LSLIDRVEKITNEEAISTARRLMEEEGILAGISSGAAVAAALKLIELPEFADKNIVVILPSSGERYLSTPLFADLFTEKE 319
Cdd:PLN02565 237 VDLLDEVVQVSSDEAIETAKLLALKEGLLVGISSGAAAAAAIKIAKRPENAGKLIVVIFPSFGERYLSSVLFESVKKEAE 316
PLN00011 PLN00011
cysteine synthase
 4-319 5.25e-109

cysteine synthase


Pssm-ID: 177651  Cd Length: 323  Bit Score: 320.03  E-value: 5.25e-109
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719   4 IYEDNSQTIGHTPLVRLNRIGNG---RILAKVESRNPSFSVKCRIGANMIWDAEKRGVLKKG-VQIVEPTSGNTGIALAF 79
Cdd:PLN00011   7 IKNDVTELIGNTPMVYLNNIVDGcvaRIAAKLEMMEPCSSVKDRIAYSMIKDAEDKGLITPGkSTLIEATAGNTGIGLAC 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719  80 VAAARGYKLTLTMPESMSLERRKLLKALGANLVLTEAAKGMKGAIAKAEEIVAADPQrNLLLQQFNNPANPEIHEKTTGP 159
Cdd:PLN00011  87 IGAARGYKVILVMPSTMSLERRIILRALGAEVHLTDQSIGLKGMLEKAEEILSKTPG-GYIPQQFENPANPEIHYRTTGP 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719 160 EIWQDTDGEIDVFIAGVGTGGTLTGVSRYIKNtKGKKIISVAVEPTDSPVISQAlageelKPGPHKIQGIGAGFIPGNLD 239
Cdd:PLN00011 166 EIWRDSAGKVDILVAGVGTGGTATGVGKFLKE-KNKDIKVCVVEPVESAVLSGG------QPGPHLIQGIGSGIIPFNLD 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719 240 LSLIDRVEKITNEEAISTARRLMEEEGILAGISSGAAVAAALKLIELPEFADKNIVVILPSSGERYLSTPLFADLFTEKE 319
Cdd:PLN00011 239 LTIVDEIIQVTGEEAIETAKLLALKEGLLVGISSGAAAAAALKVAKRPENAGKLIVVIFPSGGERYLSTKLFESVRYEAE 318
PLN03013 PLN03013
cysteine synthase
 4-322 2.36e-107

cysteine synthase


Pssm-ID: 178587 [Multi-domain]  Cd Length: 429  Bit Score: 319.80  E-value: 2.36e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719   4 IYEDNSQTIGHTPLVRLNRIGNG---RILAKVESRNPSFSVKCRIGANMIWDAEKRGVLKKGVQI-VEPTSGNTGIALAF 79
Cdd:PLN03013 113 IADNVSQLIGKTPMVYLNSIAKGcvaNIAAKLEIMEPCCSVKDRIGYSMVTDAEQKGFISPGKSVlVEPTSGNTGIGLAF 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719  80 VAAARGYKLTLTMPESMSLERRKLLKALGANLVLTEAAKGMKGAIAKAEEIVAADPQRnLLLQQFNNPANPEIHEKTTGP 159
Cdd:PLN03013 193 IAASRGYRLILTMPASMSMERRVLLKAFGAELVLTDPAKGMTGAVQKAEEILKNTPDA-YMLQQFDNPANPKIHYETTGP 271

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719 160 EIWQDTDGEIDVFIAGVGTGGTLTGVSRYIKNtKGKKIISVAVEPTDSPVISQAlageelKPGPHKIQGIGAGFIPGNLD 239
Cdd:PLN03013 272 EIWDDTKGKVDIFVAGIGTGGTITGVGRFIKE-KNPKTQVIGVEPTESDILSGG------KPGPHKIQGIGAGFIPKNLD 344

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719 240 LSLIDRVEKITNEEAISTARRLMEEEGILAGISSGAAVAAALKLIELPEFADKNIVVILPSSGeRYLSTPLFADLFTEKE 319
Cdd:PLN03013 345 QKIMDEVIAISSEEAIETAKQLALKEGLMVGISSGAAAAAAIKVAKRPENAGKLIAVSLFASG-RDIYTPRCSSLSGKRW 423


                 ...
gi 827402719 320 LQQ 322
Cdd:PLN03013 424 RKC 426
PLN02556 PLN02556
cysteine synthase/L-3-cyanoalanine synthase
 2-322 8.41e-98

cysteine synthase/L-3-cyanoalanine synthase


Pssm-ID: 178171 [Multi-domain]  Cd Length: 368  Bit Score: 293.02  E-value: 8.41e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719   2 TKIYEDNSQTIGHTPLVRLNRIGNG---RILAKVESRNPSFSVKCRIGANMIWDAEKRGVLKKG-VQIVEPTSGNTGIAL 77
Cdd:PLN02556  47 TKIKTDASQLIGKTPLVYLNKVTEGcgaYIAAKQEMFQPTSSIKDRPALAMIEDAEKKNLITPGkTTLIEPTSGNMGISL 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719  78 AFVAAARGYKLTLTMPESMSLERRKLLKALGANLVLTEAAKGMKGAIAKAEEIVAADPQRnLLLQQFNNPANPEIHEKTT 157
Cdd:PLN02556 127 AFMAAMKGYKMILTMPSYTSLERRVTMRAFGAELVLTDPTKGMGGTVKKAYELLESTPDA-FMLQQFSNPANTQVHFETT 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719 158 GPEIWQDTDGEIDVFIAGVGTGGTLTGVSRYIKnTKGKKIISVAVEPTDSPVISQAlageelKPGPHKIQGIGAGFIPGN 237
Cdd:PLN02556 206 GPEIWEDTLGQVDIFVMGIGSGGTVSGVGKYLK-SKNPNVKIYGVEPAESNVLNGG------KPGPHHITGNGVGFKPDI 278

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719 238 LDLSLIDRVEKITNEEAISTARRLMEEEGILAGISSGAAVAAALKLIELPEFADKNIVVILPSSGERYLSTPLFADLFTE 317
Cdd:PLN02556 279 LDMDVMEKVLEVSSEDAVNMARELALKEGLMVGISSGANTVAALRLAKMPENKGKLIVTVHPSFGERYLSSVLFQELRKE 358


                 ....*
gi 827402719 318 KELQQ 322
Cdd:PLN02556 359 AENMQ 363
cysM PRK11761
cysteine synthase CysM;
10-311 2.62e-96

cysteine synthase CysM;


Pssm-ID: 236972  Cd Length: 296  Bit Score: 286.77  E-value: 2.62e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719  10 QTIGHTPLVRLNRIG---NGRILAKVESRNPSFSVKCRIGANMIWDAEKRGVLKKGVQIVEPTSGNTGIALAFVAAARGY 86
Cdd:PRK11761   8 DTIGNTPLVKLQRLPpdrGNTILAKLEGNNPAGSVKDRPALSMIVQAEKRGEIKPGDTLIEATSGNTGIALAMIAAIKGY 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719  87 KLTLTMPESMSLERRKLLKALGANLVLTEAAKGMKGAIAKAEEIVAADpqRNLLLQQFNNPANPEIHEKTTGPEIWQDTD 166
Cdd:PRK11761  88 RMKLIMPENMSQERRAAMRAYGAELILVPKEQGMEGARDLALQMQAEG--EGKVLDQFANPDNPLAHYETTGPEIWRQTE 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719 167 GEIDVFIAGVGTGGTLTGVSRYIKnTKGKKIISVAVEPTDSPVIsqalageelkPGphkIQGIGAGFIPGNLDLSLIDRV 246
Cdd:PRK11761 166 GRITHFVSSMGTTGTIMGVSRYLK-EQNPAVQIVGLQPEEGSSI----------PG---IRRWPEEYLPKIFDASRVDRV 231

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 827402719 247 EKITNEEAISTARRLMEEEGILAGISSGAAVAAALKLIElpEFADKNIVVILPSSGERYLSTPLF 311
Cdd:PRK11761 232 LDVSQQEAENTMRRLAREEGIFCGVSSGGAVAAALRIAR--ENPNAVIVAIICDRGDRYLSTGVF 294
cysM TIGR01138
cysteine synthase B; CysM differs from CysK in that it can also use thiosulfate instead of ...
 10-311 3.65e-80

cysteine synthase B; CysM differs from CysK in that it can also use thiosulfate instead of sulfide, to produce cysteine thiosulfonate instead of cysteine. Alternate name: O-acetylserine (thiol)-lyase [Amino acid biosynthesis, Serine family]


Pssm-ID: 130208 [Multi-domain]  Cd Length: 290  Bit Score: 245.59  E-value: 3.65e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719   10 QTIGHTPLVRLNRIG---NGRILAKVESRNPSFSVKCRIGANMIWDAEKRGVLKKGVQIVEPTSGNTGIALAFVAAARGY 86
Cdd:TIGR01138   4 QTVGNTPLVRLQRMGpenGSEVWLKLEGNNPAGSVKDRPALSMIVEAEKRGEIKPGDVLIEATSGNTGIALAMIAALKGY 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719   87 KLTLTMPESMSLERRKLLKALGANLVLTEAAKGMKGAIAKAEEIVAADPQRnlLLQQFNNPANPEIHEKTTGPEIWQDTD 166
Cdd:TIGR01138  84 RMKLLMPDNMSQERKAAMRAYGAELILVTKEEGMEGARDLALELANRGEGK--LLDQFNNPDNPYAHYTSTGPEIWQQTG 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719  167 GEIDVFIAGVGTGGTLTGVSRYIKnTKGKKIISVAVEPTDSPVIsqalageelkPGphkIQGIGAGFIPGNLDLSLIDRV 246
Cdd:TIGR01138 162 GRITHFVSSMGTTGTIMGVSRFLK-EQNPPVQIVGLQPEEGSSI----------PG---IRRWPTEYLPGIFDASLVDRV 227

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 827402719  247 EKITNEEAISTARRLMEEEGILAGISSGAAVAAALKLIElpEFADKNIVVILPSSGERYLSTPLF 311
Cdd:TIGR01138 228 LDIHQRDAENTMRELAVREGIFCGVSSGGAVAAALRLAR--ELPDAVVVAIICDRGDRYLSTGVF 290
cysta_beta TIGR01137
cystathionine beta-synthase; Members of this family closely resemble cysteine synthase but ...
 4-307 6.59e-79

cystathionine beta-synthase; Members of this family closely resemble cysteine synthase but contain an additional C-terminal CBS domain. The function of any bacterial member included in this family is proposed but not proven. [Amino acid biosynthesis, Serine family]


Pssm-ID: 273464 [Multi-domain]  Cd Length: 455  Bit Score: 247.41  E-value: 6.59e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719    4 IYEDNSQTIGHTPLVRLNRIGNG---RILAKVESRNPSFSVKCRIGANMIWDAEKRGVLKKGVQIVEPTSGNTGIALAFV 80
Cdd:TIGR01137   1 ILDNILDLIGNTPLVRLNKVSKGlkcELLAKCEFFNPGGSVKDRIALRMIEDAEASGRLKPGDTIIEPTSGNTGIGLALV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719   81 AAARGYKLTLTMPESMSLERRKLLKALGANLVLTEAAKGM---KGAIAKAEEIVAADPQrNLLLQQFNNPANPEIHEKTT 157
Cdd:TIGR01137  81 AAIKGYKCIIVLPEKMSSEKVDVLRALGAEIVRTPTAAAFdspESHIGVAKRLVREIPG-AHILDQYRNPSNPLAHYDTT 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719  158 GPEIWQDTDGEIDVFIAGVGTGGTLTGVSRYIKNtKGKKIISVAVEPTDSpVISQALAGEELKPGPHKIQGIGAGFIPGN 237
Cdd:TIGR01137 160 GPEILEQCEGKLDMFVAGVGTGGTITGIARYLKE-SCPGCRIVGADPEGS-ILAQPEELNQTGRTPYKVEGIGYDFIPTV 237

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719  238 LDLSLIDRVEKITNEEAISTARRLMEEEGILAGISSGAAVAAALKLIELPEFADKNIVVILPSSGERYLS 307
Cdd:TIGR01137 238 LDRKVVDEWIKTDDKESFTMARRLIKEEGLLVGGSSGSAVVAALKAAEDELQEGQRCVVLLPDSIRNYMT 307
PALP pfam00291
Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate ...
 9-299 2.39e-67

Pyridoxal-phosphate dependent enzyme; Members of this family are all pyridoxal-phosphate dependent enzymes. This family includes: serine dehydratase EC:4.2.1.13 P20132, threonine dehydratase EC:4.2.1.16, tryptophan synthase beta chain EC:4.2.1.20, threonine synthase EC:4.2.99.2, cysteine synthase EC:4.2.99.8 P11096, cystathionine beta-synthase EC:4.2.1.22, 1-aminocyclopropane-1-carboxylate deaminase EC:4.1.99.4.


Pssm-ID: 459749 [Multi-domain]  Cd Length: 295  Bit Score: 212.56  E-value: 2.39e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719    9 SQTIGHTPLVRLNRIG---NGRILAKVESRNPSFSVKCRIGANMIWDAEKRgvlKKGVQIVEPTSGNTGIALAFVAAARG 85
Cdd:pfam00291   2 SLGIGPTPLVRLPRLSkelGVDVYLKLESLNPTGSFKDRGALNLLLRLKEG---EGGKTVVEASSGNHGRALAAAAARLG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719   86 YKLTLTMPESMSLERRKLLKALGANLVLTEAakGMKGAIAKAEEIvAADPQRNLLLQQFNNPANPEIHeKTTGPEIWQDT 165
Cdd:pfam00291  79 LKVTIVVPEDAPPGKLLLMRALGAEVVLVGG--DYDEAVAAAREL-AAEGPGAYYINQYDNPLNIEGY-GTIGLEILEQL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719  166 DGEIDVFIAGVGTGGTLTGVSRYIKNTKGK-KIIsvAVEPTDSPVISQALAG---EELKPGPHKIQGIGAGFIPGNLDLS 241
Cdd:pfam00291 155 GGDPDAVVVPVGGGGLIAGIARGLKELGPDvRVI--GVEPEGAPALARSLAAgrpVPVPVADTIADGLGVGDEPGALALD 232

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 827402719  242 LIDR----VEKITNEEAISTARRLMEEEGILAGISSGAAVaAALKLIELPEF-ADKNIVVILP 299
Cdd:pfam00291 233 LLDEyvgeVVTVSDEEALEAMRLLARREGIVVEPSSAAAL-AALKLALAGELkGGDRVVVVLT 294
Trp-synth-beta_II cd00640
Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP) ...
 15-301 2.16e-66

Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan synthase beta chain (Trp-synth_B), cystathionine beta-synthase (CBS), O-acetylserine sulfhydrylase (CS), serine dehydratase (Ser-dehyd), threonine dehydratase (Thr-dehyd), diaminopropionate ammonia lyase (DAL), and threonine synthase (Thr-synth). ACCD catalyzes the conversion of 1-aminocyclopropane-1-carboxylate to alpha-ketobutyrate and ammonia. Tryptophan synthase folds into a tetramer, where the beta chain is the catalytic PLP-binding subunit and catalyzes the formation of L-tryptophan from indole and L-serine. CBS is a tetrameric hemeprotein that catalyzes condensation of serine and homocysteine to cystathionine. CS is a homodimer that catalyzes the formation of L-cysteine from O-acetyl-L-serine. Ser-dehyd catalyzes the conversion of L- or D-serine to pyruvate and ammonia. Thr-dehyd is active as a homodimer and catalyzes the conversion of L-threonine to 2-oxobutanoate and ammonia. DAL is also a homodimer and catalyzes the alpha, beta-elimination reaction of both L- and D-alpha, beta-diaminopropionate to form pyruvate and ammonia. Thr-synth catalyzes the formation of threonine and inorganic phosphate from O-phosphohomoserine.


Pssm-ID: 107202 [Multi-domain]  Cd Length: 244  Bit Score: 208.52  E-value: 2.16e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719  15 TPLVRLNRI---GNGRILAKVESRNPSFSVKCRIGANMIWDAEKRGVLKKGVqIVEPTSGNTGIALAFVAAARGYKLTLT 91
Cdd:cd00640    1 TPLVRLKRLsklGGANIYLKLEFLNPTGSFKDRGALNLILLAEEEGKLPKGV-IIESTGGNTGIALAAAAARLGLKCTIV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719  92 MPESMSLERRKLLKALGANLVLTEAakGMKGAIAKAEEIVAADPqRNLLLQQFNNPANPEIHeKTTGPEIWQDTDGE-ID 170
Cdd:cd00640   80 MPEGASPEKVAQMRALGAEVVLVPG--DFDDAIALAKELAEEDP-GAYYVNQFDNPANIAGQ-GTIGLEILEQLGGQkPD 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719 171 VFIAgvgtggtltgvsryikntkgkkiisvaveptdsPVISQALAGeelkpgphkiqGIGAGFIPGNLDLSLI---DRVE 247
Cdd:cd00640  156 AVVV---------------------------------PVGGGGNIA-----------GIARALKELLPNVKVIgvePEVV 191

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 827402719 248 KITNEEAISTARRLMEEEGILAGISSGAAVAAALKLIELPEfADKNIVVILPSS 301
Cdd:cd00640  192 TVSDEEALEAIRLLAREEGILVEPSSAAALAAALKLAKKLG-KGKTVVVILTGG 244
PLN02356 PLN02356
phosphateglycerate kinase
 10-307 6.67e-30

phosphateglycerate kinase


Pssm-ID: 215204  Cd Length: 423  Bit Score: 117.78  E-value: 6.67e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719  10 QTIGHTPLVRLNRIGNG---RILAKVESRNPSFSVKCRIGANMIWDAEKRGVLKKGVQIVEPTSGNTGIALAFVAAARGY 86
Cdd:PLN02356  49 DAIGNTPLIRINSLSEAtgcEILGKCEFLNPGGSVKDRVAVKIIEEALESGQLFPGGVVTEGSAGSTAISLATVAPAYGC 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719  87 KLTLTMPESMSLERRKLLKALGA---------------------------NLVLTEAAKGMK----------GAIAKAEE 129
Cdd:PLN02356 129 KCHVVIPDDVAIEKSQILEALGAtvervrpvsithkdhyvniarrraleaNELASKRRKGSEtdgihlektnGCISEEEK 208

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719 130 ---IVAADPQRNLLLQQFNNPANPEIHEKTTGPEIWQDTDGEIDVFIAGVGTGGTLTGVSRYIKNtKGKKIISVAVEPTD 206
Cdd:PLN02356 209 ensLFSSSCTGGFFADQFENLANFRAHYEGTGPEIWEQTQGNLDAFVAAAGTGGTLAGVSRFLQE-KNPNIKCFLIDPPG 287

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719 207 SPVISQALAG-----EE-----LK-PGPHKIQGIGAGFIPGNLDLSLIDRVEKITNEEAISTARRLMEEEGILAGISSGA 275
Cdd:PLN02356 288 SGLFNKVTRGvmytrEEaegrrLKnPFDTITEGIGINRLTQNFLMAKLDGAFRGTDKEAVEMSRYLLKNDGLFVGSSSAM 367

                        330       340       350
                 ....*....|....*....|....*....|....
gi 827402719 276 AVAAALKLIEL--PefaDKNIVVILPSSGERYLS 307
Cdd:PLN02356 368 NCVGAVRVAQSlgP---GHTIVTILCDSGMRHLS 398
Thr-dehyd cd01562
Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. ...
 9-302 2.95e-18

Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly converted into NH4+. The direct deamination is catalyzed by threonine dehydratase, in which pyridoxal phosphate (PLP) is the prosthetic group. Threonine dehydratase is widely distributed in all three major phylogenetic divisions.


Pssm-ID: 107205 [Multi-domain]  Cd Length: 304  Bit Score: 83.31  E-value: 2.95e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719   9 SQTIGHTPLVR---LNRIGNGRILAKVESRNPSFSVKCRiGA-NMIW--DAEKRgvlKKGVqiVEPTSGNTGIALAFVAA 82
Cdd:cd01562   12 KPVVRRTPLLTsptLSELLGAEVYLKCENLQKTGSFKIR-GAyNKLLslSEEER---AKGV--VAASAGNHAQGVAYAAK 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719  83 ARGYKLTLTMPESMSLERRKLLKALGANLVLTEAakGMKGAIAKAEEIVAadpQRNLLlqqFNNPANpeiHEK------T 156
Cdd:cd01562   86 LLGIPATIVMPETAPAAKVDATRAYGAEVVLYGE--DFDEAEAKARELAE---EEGLT---FIHPFD---DPDviagqgT 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719 157 TGPEIWQDTdGEID-VF-----------IAGvgtggtltgvsrYIKNTKGK-KIIsvAVEPTDSPVISQAL-AGE--ELK 220
Cdd:cd01562  155 IGLEILEQV-PDLDaVFvpvggggliagIAT------------AVKALSPNtKVI--GVEPEGAPAMAQSLaAGKpvTLP 219

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719 221 PGPHKIQGIgAGFIPGNLDLSLI----DRVEKITNEEAISTARRLMEEEGILAGISSGAAVAAALKLIElpEFADKNIVV 296
Cdd:cd01562  220 EVDTIADGL-AVKRPGELTFEIIrklvDDVVTVSEDEIAAAMLLLFEREKLVAEPAGALALAALLSGKL--DLKGKKVVV 296


                 ....*.
gi 827402719 297 ILpsSG 302
Cdd:cd01562  297 VL--SG 300
IlvA COG1171
Threonine deaminase [Amino acid transport and metabolism]; Threonine deaminase is part of the ...
 14-302 5.86e-18

Threonine deaminase [Amino acid transport and metabolism]; Threonine deaminase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


Pssm-ID: 440784 [Multi-domain]  Cd Length: 327  Bit Score: 82.78  E-value: 5.86e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719  14 HTPLVR---LNRIGNGRILAKVESRNPSFSVKCRIGANMIW--DAEKRgvlKKGVqiVEPTSGNTGIALAFVAAARGYKL 88
Cdd:COG1171   24 RTPLLRsptLSERLGAEVYLKLENLQPTGSFKLRGAYNALAslSEEER---ARGV--VAASAGNHAQGVAYAARLLGIPA 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719  89 TLTMPESMSLERRKLLKALGANLVLTEAAkgMKGAIAKAEEIVAadpQRNL-LLQQFNNP------AnpeihekTTGPEI 161
Cdd:COG1171   99 TIVMPETAPAVKVAATRAYGAEVVLHGDT--YDDAEAAAAELAE---EEGAtFVHPFDDPdviagqG-------TIALEI 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719 162 WQDTdGEID-VF-----------IAGvgtggtltgvsrYIKNTKgKKIISVAVEPTDSPVISQALAGEELK--PGPHKI- 226
Cdd:COG1171  167 LEQL-PDLDaVFvpvggggliagVAA------------ALKALS-PDIRVIGVEPEGAAAMYRSLAAGEPVtlPGVDTIa 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719 227 QGIGAGfIPGNLDLSLI----DRVEKITNEEAISTARRLMEEEGILAGISSGAAVAAALKLIElpEFADKNIVVILpsSG 302
Cdd:COG1171  233 DGLAVG-RPGELTFEILrdlvDDIVTVSEDEIAAAMRLLLERTKIVVEPAGAAALAALLAGKE--RLKGKRVVVVL--SG 307
ThrC COG0498
Threonine synthase [Amino acid transport and metabolism]; Threonine synthase is part of the ...
 13-298 2.25e-14

Threonine synthase [Amino acid transport and metabolism]; Threonine synthase is part of the Pathway/BioSystem: Threonine biosynthesis


Pssm-ID: 440264 [Multi-domain]  Cd Length: 394  Bit Score: 72.93  E-value: 2.25e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719  13 GHTPLVRLNRIGN---GRILAKVESRNPSFSVKCR---IGANMiwdAEKRGVLKkgvqIVEPTSGNTGIALAFVAAARGY 86
Cdd:COG0498   65 GGTPLVKAPRLADelgKNLYVKEEGHNPTGSFKDRamqVAVSL---ALERGAKT----IVCASSGNGSAALAAYAARAGI 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719  87 KLTLTMPES-MSLERRKLLKALGANLVLTE-----AAKGMKgAIAKAEEIVAAdpqrnlllqqfnNPANPEIHE--KTTG 158
Cdd:COG0498  138 EVFVFVPEGkVSPGQLAQMLTYGAHVIAVDgnfddAQRLVK-ELAADEGLYAV------------NSINPARLEgqKTYA 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719 159 PEIWQDTDGEIDVF----------IAGVgtggtltgvsryikntKGKK------IIS-----VAVEPTDSPVISQALAGE 217
Cdd:COG0498  205 FEIAEQLGRVPDWVvvptgnggniLAGY----------------KAFKelkelgLIDrlprlIAVQATGCNPILTAFETG 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719 218 ELKPGPHKIQ------GIGagfIPGNLD--LSLIDR----VEKITNEEAISTARRLMEEEGILAGISSGAAVAAALKLIE 285
Cdd:COG0498  269 RDEYEPERPEtiapsmDIG---NPSNGEraLFALREsggtAVAVSDEEILEAIRLLARREGIFVEPATAVAVAGLRKLRE 345

                        330
                 ....*....|...
gi 827402719 286 LPEFADKNIVVIL 298
Cdd:COG0498  346 EGEIDPDEPVVVL 358
Thr-synth_1 cd01563
Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last ...
 13-302 1.79e-11

Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants, OPH is an intermediate between the methionine and threonine/isoleucine pathways. Thus threonine synthase competes for OPH with cystathionine-gamma-synthase, the first enzyme in the methionine pathway. These enzymes are in general dimers. Members of this CD, Thr-synth_1, are widely distributed in bacteria, archaea and higher plants.


Pssm-ID: 107206 [Multi-domain]  Cd Length: 324  Bit Score: 64.15  E-value: 1.79e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719  13 GHTPLVRLNRI----GNGRILAKVESRNPSFSVKCRiGANM-IWDAEKRGVlkkgVQIVEPTSGNTGIALAFVAAARGYK 87
Cdd:cd01563   21 GNTPLVRAPRLgerlGGKNLYVKDEGLNPTGSFKDR-GMTVaVSKAKELGV----KAVACASTGNTSASLAAYAARAGIK 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719  88 LTLTMPESMSLErrKLLKAL--GANLVLTEaakgmkGAIAKAEEIVAADPQRNLLLqqFNNPANPEIHE--KTTGPEIWQ 163
Cdd:cd01563   96 CVVFLPAGKALG--KLAQALayGATVLAVE------GNFDDALRLVRELAEENWIY--LSNSLNPYRLEgqKTIAFEIAE 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719 164 DTDGEI-DVFIAgvgtggTLTGVSRYIKNTKGKK------IIS-----VAVEPTDSPVISQAL--AGEELKPG--PHKI- 226
Cdd:cd01563  166 QLGWEVpDYVVV------PVGNGGNITAIWKGFKelkelgLIDrlprmVGVQAEGAAPIVRAFkeGKDDIEPVenPETIa 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719 227 QGIGAGFiPGNLDLSL--IDR----VEKITNEEAISTARRLMEEEGILAGISSGAAVAAALKLIELPEFA-DKNIVVILP 299
Cdd:cd01563  240 TAIRIGN-PASGPKALraVREsggtAVAVSDEEILEAQKLLARTEGIFVEPASAASLAGLKKLREEGIIDkGERVVVVLT 318


                 ...
gi 827402719 300 SSG 302
Cdd:cd01563  319 GHG 321
L-Ser-dehyd cd06448
Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the ...
 14-297 2.59e-11

Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- , D-serine, or L-threonine to pyruvate/ketobutyrate and ammonia.


Pssm-ID: 107209  Cd Length: 316  Bit Score: 63.47  E-value: 2.59e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719  14 HTPLVR---LNRIGNGRILAKVESRNPSFSVKCR-IGaNMIWDAEKRGvLKKGVQIVEPTSGNTGIALAFVAAARGYKLT 89
Cdd:cd06448    1 KTPLIEstaLSKTAGCNVFLKLENLQPSGSFKIRgIG-HLCQKSAKQG-LNECVHVVCSSGGNAGLAAAYAARKLGVPCT 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719  90 LTMPESMSLERRKLLKALGANLVLTEAAKGmKGAIAKAEEIVAADPqRNLLLQQFNNPANPEIHeKTTGPEIWQD--TDG 167
Cdd:cd06448   79 IVVPESTKPRVVEKLRDEGATVVVHGKVWW-EADNYLREELAENDP-GPVYVHPFDDPLIWEGH-SSMVDEIAQQlqSQE 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719 168 EIDVFIAGVGTGGTLTGVSRYIKNTKGKKIISVAVEPTDSPVISQAL-AGE--ELKPGPHKIQGIGAGFIPgnlDLSLID 244
Cdd:cd06448  156 KVDAIVCSVGGGGLLNGIVQGLERNGWGDIPVVAVETEGAHSLNASLkAGKlvTLPKITSVATSLGAKTVS---SQALEY 232

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 827402719 245 ------RVEKITNEEAISTARRLMEEEGILAGISSGAAVAAA------LKLIELPEFADKNIVVI 297
Cdd:cd06448  233 aqehniKSEVVSDRDAVQACLRFADDERILVEPACGAALAVVysgkilDLQLEVLLTPLDNVVVV 297
PRK06815 PRK06815
threonine/serine dehydratase;
15-298 3.99e-11

threonine/serine dehydratase;


Pssm-ID: 180709 [Multi-domain]  Cd Length: 317  Bit Score: 62.79  E-value: 3.99e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719  15 TPL---VRLNRIGNGRILAKVESRNPSFSVKCRIGANMI--WDAEKRgvlKKGVqiVEPTSGNTGIALAFVAAARGYKLT 89
Cdd:PRK06815  21 TPLehsPLLSQHTGCEVYLKCEHLQHTGSFKFRGASNKLrlLNEAQR---QQGV--ITASSGNHGQGVALAAKLAGIPVT 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719  90 LTMPESMSLERRKLLKALGANLVLTeaakGMKGAIAKAEEIVAADPQRNLLLQQFNnpaNPEI--HEKTTGPEIWQDTDG 167
Cdd:PRK06815  96 VYAPEQASAIKLDAIRALGAEVRLY----GGDALNAELAARRAAEQQGKVYISPYN---DPQViaGQGTIGMELVEQQPD 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719 168 EIDVFIAGVGTGGTLTGVSrYIKnTKGKKIISVAVEPTDSPVISQAL-AGE--ELKPGPHKIQGIGAGFIPGNLDLSLID 244
Cdd:PRK06815 169 LDAVFVAVGGGGLISGIAT-YLK-TLSPKTEIIGCWPANSPSLYTSLeAGEivEVAEQPTLSDGTAGGVEPGAITFPLCQ 246

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 827402719 245 RV--EKIT-NEEAISTARRLM--EEEGILAGiSSGAAVAAALKLIelPEFADKNIVVIL 298
Cdd:PRK06815 247 QLidQKVLvSEEEIKEAMRLIaeTDRWLIEG-AAGVALAAALKLA--PRYQGKKVAVVL 302
PRK05638 PRK05638
threonine synthase; Validated
 13-302 9.13e-09

threonine synthase; Validated


Pssm-ID: 235539 [Multi-domain]  Cd Length: 442  Bit Score: 56.36  E-value: 9.13e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719  13 GHTPLVRlNRIG---NGRILAKVESRNPSFSVKCRIGANMIWDAEKRGvlKKGvqIVEPTSGNTGIALAFVAAARGYKLT 89
Cdd:PRK05638  65 GGTPLIR-ARISeklGENVYIKDETRNPTGSFRDRLATVAVSYGLPYA--ANG--FIVASDGNAAASVAAYSARAGKEAF 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719  90 LTMPESMSLERRKLLKALGANLV-----LTEAAKGMKGaIAKAEEIVAADPQRNLLLQQfnnpanpeiHEKTTGPEIWQD 164
Cdd:PRK05638 140 VVVPRKVDKGKLIQMIAFGAKIIrygesVDEAIEYAEE-LARLNGLYNVTPEYNIIGLE---------GQKTIAFELWEE 209

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719 165 TdGEIDVFIAGVGTGGTLTGV---SRYIKN---TKGKKIISVAVEPTdSPVISQALaGEELKPGPHKIQGIgagFIPGNL 238
Cdd:PRK05638 210 I-NPTHVIVPTGSGSYLYSIYkgfKELLEIgviEEIPKLIAVQTERC-NPIASEIL-GNKTKCNETKALGL---YVKNPV 283

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 827402719 239 DLSLIDRVEK-------ITNEEAISTARRLMEEEGILAGISSGAAVAAALKLIELPEFA-DKNIVVILPSSG 302
Cdd:PRK05638 284 MKEYVSEAIKesggtavVVNEEEIMAGEKLLAKEGIFAELSSAVVMPALLKLGEEGYIEkGDKVVLVVTGSG 355
PRK06608 PRK06608
serine/threonine dehydratase;
9-114 1.46e-08

serine/threonine dehydratase;


Pssm-ID: 235842 [Multi-domain]  Cd Length: 338  Bit Score: 55.16  E-value: 1.46e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719   9 SQTIGHTPLVR---LNRIGNGRILAKVESRNPSFSVKCRIGANMIWDAEKRGVLKKgvQIVEPTSGNTGIALAFVAAARG 85
Cdd:PRK06608  18 KQYLHLTPIVHsesLNEMLGHEIFFKVESLQKTGAFKVRGVLNHLLELKEQGKLPD--KIVAYSTGNHGQAVAYASKLFG 95

                         90       100
                 ....*....|....*....|....*....
gi 827402719  86 YKLTLTMPESMSLERRKLLKALGANLVLT 114
Cdd:PRK06608  96 IKTRIYLPLNTSKVKQQAALYYGGEVILT 124
PRK08197 PRK08197
threonine synthase; Validated
 13-133 1.66e-08

threonine synthase; Validated


Pssm-ID: 181283 [Multi-domain]  Cd Length: 394  Bit Score: 55.39  E-value: 1.66e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719  13 GHTPLVRLNR----IGNGRILAKVESRNPSFSVKCRiGANM-IWDAEKRGVlkkgVQIVEPTSGNTGIALAFVAAARGYK 87
Cdd:PRK08197  78 GMTPLLPLPRlgkaLGIGRLWVKDEGLNPTGSFKAR-GLAVgVSRAKELGV----KHLAMPTNGNAGAAWAAYAARAGIR 152

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 827402719  88 LTLTMPESMSLERRKLLKALGANLVLTEaakgmkGAIAKAEEIVAA 133
Cdd:PRK08197 153 ATIFMPADAPEITRLECALAGAELYLVD------GLISDAGKIVAE 192
PRK06450 PRK06450
threonine synthase; Validated
 13-302 3.91e-08

threonine synthase; Validated


Pssm-ID: 180565 [Multi-domain]  Cd Length: 338  Bit Score: 53.97  E-value: 3.91e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719  13 GHTPLVRlnrigNGRILAKVESRNPSFSVKCRIGANMIWDAEKRGVlkkgVQIVEPTSGNTGIALAFVAAARGYKLTLTM 92
Cdd:PRK06450  57 GRTPLIK-----KGNIWFKLDFLNPTGSYKDRGSVTLISYLAEKGI----KQISEDSSGNAGASIAAYGAAAGIEVKIFV 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719  93 PESMSLERRKLLKALGANLVlteAAKGMKGAIAKAEEIVAADPQRNLLLQQFNNPAnpeiheKTTGPEIWQDTDGEI--D 170
Cdd:PRK06450 128 PETASGGKLKQIESYGAEVV---RVRGSREDVAKAAENSGYYYASHVLQPQFRDGI------RTLAYEIAKDLDWKIpnY 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719 171 VFIAGVGTGGTLTGVS--RYIKNT----KGKKIISVAVEPTdSPVISQaLAGEELKPgPHKIQGIGAGFIPGNldLSLID 244
Cdd:PRK06450 199 VFIPVSAGTLLLGVYSgfKHLLDSgvisEMPKIVAVQTEQV-SPLCAK-FKGISYTP-PDKVTSIADALVSTR--PFLLD 273

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 827402719 245 RVEKI---------TNEEAISTARRLMEEEGILAGISSgAAVAAALKLIELpefadKNIVVILPSSG 302
Cdd:PRK06450 274 YMVKAlseygecivVSDNEIVEAWKELAKKGLLVEYSS-ATVYAAYKKYSV-----NDSVLVLTGSG 334
thrC TIGR00260
threonine synthase; Involved in threonine biosynthesis it catalyses the reaction ...
 13-285 5.24e-08

threonine synthase; Involved in threonine biosynthesis it catalyses the reaction O-PHOSPHO-L-HOMOSERINE + H(2)O = L-THREONINE + ORTHOPHOSPHATE using pyridoxal phosphate as a cofactor. the enzyme is distantly related to the serine/threonine dehydratases which are also pyridoxal-phosphate dependent enzymes. the pyridoxal-phosphate binding site is a Lys (K) residues present at residue 70 of the model. [Amino acid biosynthesis, Aspartate family]


Pssm-ID: 272986 [Multi-domain]  Cd Length: 327  Bit Score: 53.54  E-value: 5.24e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719   13 GHTPLVRLNR----IGNGRILAKVESRNPSFSVKCRIGANMIWDAEKRGVlkkgVQIVEPTSGNTGIALAFVAAARGYKL 88
Cdd:TIGR00260  21 GVTPLFRAPAlaanVGIKNLYVKELGHNPTLSFKDRGMAVALTKALELGN----DTVLCASTGNTGAAAAAYAGKAGLKV 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719   89 TLTMPESmSLERRKLLKALGANLVLTeaakGMKGAIAKAEEIV--AADPQRNLLLQQFNN-PANPEiHEKTTGPEIWQDT 165
Cdd:TIGR00260  97 VVLYPAG-KISLGKLAQALGYNAEVV----AIDGNFDDAQRLVkqLFEDKPALGLNSANSiPYRLE-GQKTYAFEAVEQL 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719  166 DGEID---VFIAGVGTGGTLTGVSRYIKNTKGKKIISV--AVEPTD-SPVISQALAGEELKP--GPHKIQGIGAGFIPGN 237
Cdd:TIGR00260 171 GWEAPdkvVVPVPNSGNFGAIWKGFKEKKMLGLDSLPVkrGIQAEGaADIVRAFLEGGQWEPieTPETLSTAMDIGNPAN 250

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 827402719  238 LD--LSLIDR----VEKITNEEAISTARRLMEEEGILAGISSGAAVAAALKLIE 285
Cdd:TIGR00260 251 WPraLEAFRRsngyAEDLSDEEILEAIKLLAREEGYFVEPHSAVAVAALLKLVE 304
PRK06381 PRK06381
threonine synthase; Validated
 1-135 7.11e-07

threonine synthase; Validated


Pssm-ID: 235789  Cd Length: 319  Bit Score: 50.09  E-value: 7.11e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719   1 MTKIYEDNSQTIGHTPLVRLNRIGN----GRILAKVESRNPSFSVKCRIGANMIWDAEKRGVlkKGVQIvePTSGNTGIA 76
Cdd:PRK06381   2 EEELSSSEEKPPGGTPLLRARKLEEelglRKIYLKFEGANPTGTQKDRIAEAHVRRAMRLGY--SGITV--GTCGNYGAS 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 827402719  77 LAFVAAARGYKLTLTMPESMSLERRKLLKALGANLVLT----EAAKGMKGAIAKAEEIVAADP 135
Cdd:PRK06381  78 IAYFARLYGLKAVIFIPRSYSNSRVKEMEKYGAEIIYVdgkyEEAVERSRKFAKENGIYDANP 140
PRK08246 PRK08246
serine/threonine dehydratase;
65-281 1.38e-05

serine/threonine dehydratase;


Pssm-ID: 181319 [Multi-domain]  Cd Length: 310  Bit Score: 46.10  E-value: 1.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719  65 IVEPTSGNTGIALAFVAAARGYKLTLTMPESMSLERRKLLKALGANLVLTEA--AKGMKGAIAKAEEIVAadpqrnLLLQ 142
Cdd:PRK08246  71 VVAASGGNAGLAVAYAAAALGVPATVFVPETAPPAKVARLRALGAEVVVVGAeyADALEAAQAFAAETGA------LLCH 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719 143 QFNnpaNPEI--HEKTTGPEIWQDTdGEID-VFIAGVGTGGTLTGVSRYikntkGKKIISVAVEPTDSPVISQALAGEEl 219
Cdd:PRK08246 145 AYD---QPEVlaGAGTLGLEIEEQA-PGVDtVLVAVGGGGLIAGIAAWF-----EGRARVVAVEPEGAPTLHAALAAGE- 214

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 827402719 220 kPGPHKIQGIGAGFIP----GNLDLSLI---DRVEKITNEEAISTARRLMEEEGILAGISSGAAVAAAL 281
Cdd:PRK08246 215 -PVDVPVSGIAADSLGarrvGEIAFALArahVVTSVLVSDEAIIAARRALWEELRLAVEPGAATALAAL 282
PRK12483 PRK12483
threonine dehydratase; Reviewed
 22-218 8.43e-05

threonine dehydratase; Reviewed


Pssm-ID: 237111 [Multi-domain]  Cd Length: 521  Bit Score: 44.02  E-value: 8.43e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719  22 RIGNgRILAKVESRNPSFSVKCRIG----ANMIWDAEKRGVlkkgvqiVEPTSGNTGIALAFVAAARGYKLTLTMPESMS 97
Cdd:PRK12483  49 RLGN-QVLLKREDLQPVFSFKIRGAynkmARLPAEQLARGV-------ITASAGNHAQGVALAAARLGVKAVIVMPRTTP 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719  98 LERRKLLKALGANLVLteAAKGMKGAIAKAEEIvaADPQRNLLLQQFNNPaNPEIHEKTTGPEIWQDTDGEIDVFIAGVG 177
Cdd:PRK12483 121 QLKVDGVRAHGGEVVL--HGESFPDALAHALKL--AEEEGLTFVPPFDDP-DVIAGQGTVAMEILRQHPGPLDAIFVPVG 195

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 827402719 178 TGGTLTGVSRYIKNTKgKKIISVAVEPTDSPVISQALAGEE 218
Cdd:PRK12483 196 GGGLIAGIAAYVKYVR-PEIKVIGVEPDDSNCLQAALAAGE 235
Trp-synth_B cd06446
Tryptophan synthase-beta: Tryptophan synthase is a bifunctional enzyme that catalyses the ...
 249-302 5.04e-04

Tryptophan synthase-beta: Tryptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to glyceraldehyde 3-phosphate and indole at the active site of the alpha subunit. In the beta reaction, indole undergoes a PLP-dependent reaction with L-serine to form L-tryptophan at the active site of the beta subunit. Members of this CD, Trp-synth_B, are found in all three major phylogenetic divisions.


Pssm-ID: 107207  Cd Length: 365  Bit Score: 41.37  E-value: 5.04e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 827402719 249 ITNEEAISTARRLMEEEGILAGISSGAAVAAALKL-IELPEfaDKNIVVILpsSG 302
Cdd:cd06446  306 VTDEEALEAFKLLARTEGIIPALESSHAIAYAIKLaKKLGK--EKVIVVNL--SG 356
PRK08638 PRK08638
bifunctional threonine ammonia-lyase/L-serine ammonia-lyase TdcB;
15-134 5.35e-04

bifunctional threonine ammonia-lyase/L-serine ammonia-lyase TdcB;


Pssm-ID: 236317 [Multi-domain]  Cd Length: 333  Bit Score: 41.26  E-value: 5.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719  15 TPLVRLNRIGN---GRILAKVESRNPSFSVKCRIGANMI---WDAEKRgvlkKGVqiVEPTSGNTGIALAFVAAARGYKL 88
Cdd:PRK08638  28 TPLPRSNYLSErckGEIFLKLENMQRTGSFKIRGAFNKLsslTDAEKR----KGV--VACSAGNHAQGVALSCALLGIDG 101

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 827402719  89 TLTMPESMSLERRKLLKALGANLVLteAAKGMKGAIAKAEEIVAAD 134
Cdd:PRK08638 102 KVVMPKGAPKSKVAATCGYGAEVVL--HGDNFNDTIAKVEEIVEEE 145
PRK06110 PRK06110
threonine dehydratase;
31-112 5.91e-04

threonine dehydratase;


Pssm-ID: 235699  Cd Length: 322  Bit Score: 41.13  E-value: 5.91e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719  31 KVESRNPSFSVKCRIGANMIWDAEKRGVLKKGVqiVEPTSGNTGIALAFVAAARGYKLTLTMPESMSLERRKLLKALGAN 110
Cdd:PRK06110  41 KHENHTPTGAFKVRGGLVYFDRLARRGPRVRGV--ISATRGNHGQSVAFAARRHGLAATIVVPHGNSVEKNAAMRALGAE 118


                 ..
gi 827402719 111 LV 112
Cdd:PRK06110 119 LI 120
PRK13028 PRK13028
tryptophan synthase subunit beta; Provisional
 243-302 9.26e-04

tryptophan synthase subunit beta; Provisional


Pssm-ID: 183851  Cd Length: 402  Bit Score: 40.62  E-value: 9.26e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 827402719 243 IDRVE--KITNEEAISTARRLMEEEGILAGISSGAAVAAALKLI-ELPEfaDKNIVVILpsSG 302
Cdd:PRK13028 326 IGRVEyvTATDEEALDAFFLLSRTEGIIPALESSHAVAYAIKLApELSK--DETILVNL--SG 384
PRK09224 PRK09224
threonine ammonia-lyase IlvA;
14-217 1.86e-03

threonine ammonia-lyase IlvA;


Pssm-ID: 236417 [Multi-domain]  Cd Length: 504  Bit Score: 39.74  E-value: 1.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719  14 HTPLVRLN----RIGNgRILAKVESRNPSFSVKCRiGA-NMIW----DAEKRGVlkkgvqiVEPTSGN--TGIALAfvAA 82
Cdd:PRK09224  20 ETPLEKAPklsaRLGN-QVLLKREDLQPVFSFKLR-GAyNKMAqlteEQLARGV-------ITASAGNhaQGVALS--AA 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719  83 ARGYKLTLTMPESMSLERRKLLKALGANLVL-----TEAAkgmkgaiAKAEEIVAadpQRNLLLqqfnnpanpeIH---- 153
Cdd:PRK09224  89 RLGIKAVIVMPVTTPDIKVDAVRAFGGEVVLhgdsfDEAY-------AHAIELAE---EEGLTF----------IHpfdd 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 827402719 154 ------EKTTGPEIWQDTDGEID-VF-----------IAGvgtggtltgvsrYIKNTKGK-KIIsvAVEPTDSPVISQAL 214
Cdd:PRK09224 149 pdviagQGTIAMEILQQHPHPLDaVFvpvggggliagVAA------------YIKQLRPEiKVI--GVEPEDSACLKAAL 214


                 ....
gi 827402719 215 -AGE 217
Cdd:PRK09224 215 eAGE 218
PRK04346 PRK04346
tryptophan synthase subunit beta; Validated
 243-302 2.80e-03

tryptophan synthase subunit beta; Validated


Pssm-ID: 235288  Cd Length: 397  Bit Score: 39.28  E-value: 2.80e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 827402719 243 IDRVE--KITNEEAISTARRLMEEEGILAGISSGAAVAAALKLI-ELPEfaDKNIVVILpsSG 302
Cdd:PRK04346 322 IGRAEyvSITDDEALEAFQLLSRLEGIIPALESSHALAYALKLApTLGK--DQIIVVNL--SG 380
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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