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Conserved domains on  [gi|822661395|gb|AKH97219|]
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tRNA (adenine(57)-N(1)/adenine(58)-N(1))-methyltransferase [Halanaeroarchaeum sulfurireducens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Gcd14 super family cl34476
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 2-239 1.45e-59

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


The actual alignment was detected with superfamily member COG2519:

Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 188.06  E-value: 1.45e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822661395   2 ILLVRDGREFL--CAPGDEVHTDLGVVDVPTDV--SPGDVVESHLGESFavRALRgP---DLFQHLERTGAPMMPKDVGL 74
Cdd:COG2519    6 LLTDPKGRKYLvrLEEGKKFHTHKGIIDHDDLIgkPEGSVVTTSKGKEF--LVLR-PtlyDYVLSMKRGTQIIYPKDAGY 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822661395  75 VIGHTGAAAGDQVLDAGTGTGVLAAYLAR-VGAE--VRTFEEDPEFAAVARENMDLAEVADRVTVQVGDVTDHLDDASgF 151
Cdd:COG2519   83 IIARLDIFPGARVLEAGTGSGALTLALARaVGPEgkVYSYERREDFAEIARKNLERFGLPDNVELKLGDIREGIDEGD-V 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822661395 152 DLVTLDTADAVPVVERAQDLLVSGGFVAVYSPFVESAREVELAAREAGLESIETVETIQREMDFDDRGSRPATRGVGHTG 231
Cdd:COG2519  162 DAVFLDMPDPWEALEAVAKALKPGGVLVAYVPTVNQVSKLVEALRESGFTDIEAVETLLREWKVEGLAVRPEHRMVGHTG 241


                 ....*...
gi 822661395 232 YLTFGRKL 239
Cdd:COG2519  242 FLVFARKL 249
 
Name Accession Description Interval E-value
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 2-239 1.45e-59

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 188.06  E-value: 1.45e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822661395   2 ILLVRDGREFL--CAPGDEVHTDLGVVDVPTDV--SPGDVVESHLGESFavRALRgP---DLFQHLERTGAPMMPKDVGL 74
Cdd:COG2519    6 LLTDPKGRKYLvrLEEGKKFHTHKGIIDHDDLIgkPEGSVVTTSKGKEF--LVLR-PtlyDYVLSMKRGTQIIYPKDAGY 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822661395  75 VIGHTGAAAGDQVLDAGTGTGVLAAYLAR-VGAE--VRTFEEDPEFAAVARENMDLAEVADRVTVQVGDVTDHLDDASgF 151
Cdd:COG2519   83 IIARLDIFPGARVLEAGTGSGALTLALARaVGPEgkVYSYERREDFAEIARKNLERFGLPDNVELKLGDIREGIDEGD-V 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822661395 152 DLVTLDTADAVPVVERAQDLLVSGGFVAVYSPFVESAREVELAAREAGLESIETVETIQREMDFDDRGSRPATRGVGHTG 231
Cdd:COG2519  162 DAVFLDMPDPWEALEAVAKALKPGGVLVAYVPTVNQVSKLVEALRESGFTDIEAVETLLREWKVEGLAVRPEHRMVGHTG 241


                 ....*...
gi 822661395 232 YLTFGRKL 239
Cdd:COG2519  242 FLVFARKL 249
GCD14 pfam08704
tRNA methyltransferase complex GCD14 subunit; GCD14 is a subunit of the tRNA methyltransferase ...
 71-238 2.81e-14

tRNA methyltransferase complex GCD14 subunit; GCD14 is a subunit of the tRNA methyltransferase complex and is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA.


Pssm-ID: 312288  Cd Length: 242  Bit Score: 69.83  E-value: 2.81e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822661395   71 DVGLVIGHTGAAAGDQVLDAGTGTGVLAAYLARVGA---EVRTFEEDPEFAAVARENMDLAEVADRVTVQVGDVTDH--L 145
Cdd:pfam08704  28 DISLITMMLELRPGSVVCESGTGSGSLSHAIIRTVAptgHLFTFEFHEQRADKAREEFREHGIDQLVTVTHRDVCKEgfL 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822661395  146 DDASGF-DLVTLDTA---DAVPVVERAqdLLVSGGFVAVYSPFVESAREVELAAREAGLESIETVETIQREMD------- 214
Cdd:pfam08704 108 TEVSGKaDAVFLDLPspwEAVPHAWKA--LKVEGGRFCSFSPCIEQVQRTCQALAELGFTEISTLEVLLRVYDvrtvslp 185

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 822661395  215 --------------------------FDDRG-------SRPATRGVGHTGYLTFGRK 238
Cdd:pfam08704 186 vidlgidrekenertrteglsnddksEDNSGnsmlgtaLKPMSEAVGHTGYLTFATK 242
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 87-180 5.89e-08

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 49.35  E-value: 5.89e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822661395  87 VLDAGTGTGVLAAYLAR-VGAEVRTFEEDPEFAAVARENmDLAEVADRVTVQVGDVTDHLDDASG-FDLVTLDTA----- 159
Cdd:cd02440    2 VLDLGCGTGALALALASgPGARVTGVDISPVALELARKA-AAALLADNVEVLKGDAEELPPEADEsFDVIISDPPlhhlv 80

                         90       100
                 ....*....|....*....|..
gi 822661395 160 -DAVPVVERAQDLLVSGGFVAV 180
Cdd:cd02440   81 eDLARFLEEARRLLKPGGVLVL 102
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 72-154 9.67e-07

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 48.62  E-value: 9.67e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822661395  72 VGLVIGHTGAAAGDQVLDAGTGTGVLAAYLA--RVGAEVRTFEEDPEFAAVARENMDLAeVADRVTVQVGDVTDHLDDAS 149
Cdd:PRK09328  97 VEWALEALLLKEPLRVLDLGTGSGAIALALAkeRPDAEVTAVDISPEALAVARRNAKHG-LGARVEFLQGDWFEPLPGGR 175


                 ....*
gi 822661395 150 gFDLV 154
Cdd:PRK09328 176 -FDLI 179
BchM-ChlM TIGR02021
magnesium protoporphyrin O-methyltransferase; This model represents the ...
 83-157 1.60e-06

magnesium protoporphyrin O-methyltransferase; This model represents the S-adenosylmethionine-dependent O-methyltransferase responsible for methylation of magnesium protoporphyrin IX. This step is essentiasl for the biosynthesis of both chlorophyll and bacteriochlorophyll. This model encompasses two closely related clades, from cyanobacteria (and plants) where it is called ChlM and other photosynthetic bacteria where it is known as BchM. [Biosynthesis of cofactors, prosthetic groups, and carriers, Chlorophyll and bacteriochlorphyll]


Pssm-ID: 273930 [Multi-domain]  Cd Length: 219  Bit Score: 47.49  E-value: 1.60e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 822661395   83 AGDQVLDAGTGTGVLAAYLARVGAEVRTFEEDPEFAAVARENMDLAEVADRVTVQVGDVtdhLDDASGFD-LVTLD 157
Cdd:TIGR02021  55 KGKRVLDAGCGTGLLSIELAKRGAIVKAVDISEQMVQMARNRAQGRDVAGNVEFEVNDL---LSLCGEFDiVVCMD 127
rADc smart00650
Ribosomal RNA adenine dimethylases;
75-141 4.15e-05

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 42.50  E-value: 4.15e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 822661395    75 VIGHTGAAAGDQVLDAGTGTGVLAAYLARVGAEVRTFEEDPEFAAVAREnmdLAEVADRVTVQVGDV 141
Cdd:smart00650   5 IVRAANLRPGDTVLEIGPGKGALTEELLERAKRVTAIEIDPRLAPRLRE---KFAAADNLTVIHGDA 68
 
Name Accession Description Interval E-value
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 2-239 1.45e-59

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 188.06  E-value: 1.45e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822661395   2 ILLVRDGREFL--CAPGDEVHTDLGVVDVPTDV--SPGDVVESHLGESFavRALRgP---DLFQHLERTGAPMMPKDVGL 74
Cdd:COG2519    6 LLTDPKGRKYLvrLEEGKKFHTHKGIIDHDDLIgkPEGSVVTTSKGKEF--LVLR-PtlyDYVLSMKRGTQIIYPKDAGY 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822661395  75 VIGHTGAAAGDQVLDAGTGTGVLAAYLAR-VGAE--VRTFEEDPEFAAVARENMDLAEVADRVTVQVGDVTDHLDDASgF 151
Cdd:COG2519   83 IIARLDIFPGARVLEAGTGSGALTLALARaVGPEgkVYSYERREDFAEIARKNLERFGLPDNVELKLGDIREGIDEGD-V 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822661395 152 DLVTLDTADAVPVVERAQDLLVSGGFVAVYSPFVESAREVELAAREAGLESIETVETIQREMDFDDRGSRPATRGVGHTG 231
Cdd:COG2519  162 DAVFLDMPDPWEALEAVAKALKPGGVLVAYVPTVNQVSKLVEALRESGFTDIEAVETLLREWKVEGLAVRPEHRMVGHTG 241


                 ....*...
gi 822661395 232 YLTFGRKL 239
Cdd:COG2519  242 FLVFARKL 249
GCD14 pfam08704
tRNA methyltransferase complex GCD14 subunit; GCD14 is a subunit of the tRNA methyltransferase ...
 71-238 2.81e-14

tRNA methyltransferase complex GCD14 subunit; GCD14 is a subunit of the tRNA methyltransferase complex and is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA.


Pssm-ID: 312288  Cd Length: 242  Bit Score: 69.83  E-value: 2.81e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822661395   71 DVGLVIGHTGAAAGDQVLDAGTGTGVLAAYLARVGA---EVRTFEEDPEFAAVARENMDLAEVADRVTVQVGDVTDH--L 145
Cdd:pfam08704  28 DISLITMMLELRPGSVVCESGTGSGSLSHAIIRTVAptgHLFTFEFHEQRADKAREEFREHGIDQLVTVTHRDVCKEgfL 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822661395  146 DDASGF-DLVTLDTA---DAVPVVERAqdLLVSGGFVAVYSPFVESAREVELAAREAGLESIETVETIQREMD------- 214
Cdd:pfam08704 108 TEVSGKaDAVFLDLPspwEAVPHAWKA--LKVEGGRFCSFSPCIEQVQRTCQALAELGFTEISTLEVLLRVYDvrtvslp 185

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 822661395  215 --------------------------FDDRG-------SRPATRGVGHTGYLTFGRK 238
Cdd:pfam08704 186 vidlgidrekenertrteglsnddksEDNSGnsmlgtaLKPMSEAVGHTGYLTFATK 242
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 75-201 2.34e-13

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 65.02  E-value: 2.34e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822661395  75 VIGHTGAAAGDQVLDAGTGTGVLAAYLARVGAEVRTFEEDPEFAAVARENmdLAEVADRVTVQVGDVTDH-LDDASgFDL 153
Cdd:COG2226   14 LLAALGLRPGARVLDLGCGTGRLALALAERGARVTGVDISPEMLELARER--AAEAGLNVEFVVGDAEDLpFPDGS-FDL 90

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 822661395 154 VTL-----DTADAVPVVERAQDLLVSGGFVAVYSPFVESAREVELAAREAGLE 201
Cdd:COG2226   91 VISsfvlhHLPDPERALAEIARVLKPGGRLVVVDFSPPDLAELEELLAEAGFE 143
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 87-180 5.99e-13

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 64.82  E-value: 5.99e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822661395  87 VLDAGTGTGVLAAYLARV---GAEVRTFEEDPEFAAVARENMDLAEVADRVTVQVGDVTDHLDDASG--FDLVTLDTA-- 159
Cdd:COG4122   20 ILEIGTGTGYSTLWLARAlpdDGRLTTIEIDPERAAIARENFARAGLADRIRLILGDALEVLPRLADgpFDLVFIDADks 99

                         90       100
                 ....*....|....*....|.
gi 822661395 160 DAVPVVERAQDLLVSGGFVAV 180
Cdd:COG4122  100 NYPDYLELALPLLRPGGLIVA 120
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 74-183 3.10e-12

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 62.64  E-value: 3.10e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822661395  74 LVIGHTGAAAGDQVLDAGTGTGVLAAYLA-RVGAEVRTFEEDPEFAAVARENMDLAEVADRVTVQVGDVTDHLDDASgFD 152
Cdd:COG2230   42 LILRKLGLKPGMRVLDIGCGWGGLALYLArRYGVRVTGVTLSPEQLEYARERAAEAGLADRVEVRLADYRDLPADGQ-FD 120

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 822661395 153 LVT-------LDTADAVPVVERAQDLLVSGGFVAVYSP 183
Cdd:COG2230  121 AIVsigmfehVGPENYPAYFAKVARLLKPGGRLLLHTP 158
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 81-183 6.95e-12

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 60.80  E-value: 6.95e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822661395  81 AAAGDQVLDAGTGTGVLAAYLARVGAEVRTFEEDPEFAAVARENMDlaevADRVTVQVGDVTDHLDDASGFDLVTL---- 156
Cdd:COG2227   22 LPAGGRVLDVGCGTGRLALALARRGADVTGVDISPEALEIARERAA----ELNVDFVQGDLEDLPLEDGSFDLVICsevl 97

                         90       100
                 ....*....|....*....|....*...
gi 822661395 157 -DTADAVPVVERAQDLLVSGGFVAVYSP 183
Cdd:COG2227   98 eHLPDPAALLRELARLLKPGGLLLLSTP 125
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 67-176 2.10e-11

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 60.87  E-value: 2.10e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822661395  67 MMPKDVGLVIGHTGAAAGDQVLDAGTGTGVLAAYLARVGAEVRTFEEDPEFAAVARENMDLAEVaDRVTVQVGDVTDHLD 146
Cdd:COG2518   50 SQPYIVARMLEALDLKPGDRVLEIGTGSGYQAAVLARLAGRVYSVERDPELAERARERLAALGY-DNVTVRVGDGALGWP 128

                         90       100       110
                 ....*....|....*....|....*....|.
gi 822661395 147 DASGFDLVTLdTAdAVPVVERA-QDLLVSGG 176
Cdd:COG2518  129 EHAPFDRIIV-TA-AAPEVPEAlLEQLAPGG 157
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 81-204 2.91e-11

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 61.31  E-value: 2.91e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822661395  81 AAAGDQVLDAGTGTGVLAAYLA-RV-GAEVRTFEEDPEFAAVARENMDLAEVADRVTVQVGDVTDHLDD--ASGFDLVT- 155
Cdd:COG4123   35 VKKGGRVLDLGTGTGVIALMLAqRSpGARITGVEIQPEAAELARRNVALNGLEDRITVIHGDLKEFAAElpPGSFDLVVs 114

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 822661395 156 -----------------------LDTADAVPVVERAQDLLVSGG-FVAVYSPfvESAREVELAAREAGLESIE 204
Cdd:COG4123  115 nppyfkagsgrkspdearaiarhEDALTLEDLIRAAARLLKPGGrFALIHPA--ERLAEILAALRKYGLGPKR 185
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 87-176 1.30e-09

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 53.72  E-value: 1.30e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822661395   87 VLDAGTGTGVLAAYLA-RVGAEVRTFEEDPEFAAVARENMDLAEVadRVTVQVGDVTD-HLDDASgFDLVT-------LD 157
Cdd:pfam13649   1 VLDLGCGTGRLTLALArRGGARVTGVDLSPEMLERARERAAEAGL--NVEFVQGDAEDlPFPDGS-FDLVVssgvlhhLP 77

                          90
                  ....*....|....*....
gi 822661395  158 TADAVPVVERAQDLLVSGG 176
Cdd:pfam13649  78 DPDLEAALREIARVLKPGG 96
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
83-207 4.01e-09

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 55.56  E-value: 4.01e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822661395  83 AGDQVLDAGTGTGVLAAYLARVGA-EVRTFEEDPEFAAVARENMDLAEVADRVTVQVGDvtdhLDDASGFDLVT---Ldt 158
Cdd:COG2264  148 PGKTVLDVGCGSGILAIAAAKLGAkRVLAVDIDPVAVEAARENAELNGVEDRIEVVLGD----LLEDGPYDLVVaniL-- 221

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 822661395 159 ADavPVVERAQDL---LVSGGfVAVYSPFVES-AREVELAAREAGLESIETVE 207
Cdd:COG2264  222 AN--PLIELAPDLaalLKPGG-YLILSGILEEqADEVLAAYEAAGFELVERRE 271
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 72-157 7.14e-09

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 55.18  E-value: 7.14e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822661395  72 VGLVIGHTGAAAGDQVLDAGTGTGVLAAYLARVGAEVRTFEEDPEFAAVARENMDLAEVaDRVTVQVGDVTD---HLDDA 148
Cdd:COG2265  222 YAAALEWLDLTGGERVLDLYCGVGTFALPLARRAKKVIGVEIVPEAVEDARENARLNGL-KNVEFVAGDLEEvlpELLWG 300


                 ....*....
gi 822661395 149 SGFDLVTLD 157
Cdd:COG2265  301 GRPDVVVLD 309
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
83-180 9.49e-09

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 51.36  E-value: 9.49e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822661395  83 AGDQVLDAGTGTGVLAAYLAR--VGAEVRTFEEDPEFAAVARENmdlaevADRVTVQVGDVTDhLDDASGFDLVTLDTA- 159
Cdd:COG4106    1 PPRRVLDLGCGTGRLTALLAErfPGARVTGVDLSPEMLARARAR------LPNVRFVVADLRD-LDPPEPFDLVVSNAAl 73

                         90       100
                 ....*....|....*....|....*
gi 822661395 160 ----DAVPVVERAQDLLVSGGFVAV 180
Cdd:COG4106   74 hwlpDHAALLARLAAALAPGGVLAV 98
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
84-176 1.13e-08

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 53.89  E-value: 1.13e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822661395  84 GDQVLDAGTGTGVLAAYLARVGAE-VRTFEEDPEFAAVARENMDLAEVADRVTVQVGDVTDhLDDASGFDLV---TLDTA 159
Cdd:COG4076   36 GDVVLDIGTGSGLLSMLAARAGAKkVYAVEVNPDIAAVARRIIAANGLSDRITVINADATD-LDLPEKADVIiseMLDTA 114

                         90       100
                 ....*....|....*....|..
gi 822661395 160 ----DAVPVVERA-QDLLVSGG 176
Cdd:COG4076  115 lldeGQVPILNHArKRLLKPGG 136
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 72-207 1.28e-08

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 54.00  E-value: 1.28e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822661395  72 VGLVIGHTGAAAGDQVLDAGTGTGVLAAYLARV--GAEVRTFEEDPEFAAVARENMDLAEVADRVTVQVGDVTDHLDDAS 149
Cdd:COG2890  101 VELALALLPAGAPPRVLDLGTGSGAIALALAKErpDARVTAVDISPDALAVARRNAERLGLEDRVRFLQGDLFEPLPGDG 180

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822661395 150 GFDLVT-----LDTADAVP--------------------------VVERAQDLLVSGGFVAV---YSpFVESAREVelaA 195
Cdd:COG2890  181 RFDLIVsnppyIPEDEIALlppevrdheprlaldggedgldfyrrIIAQAPRLLKPGGWLLLeigED-QGEAVRAL---L 256

                        170
                 ....*....|..
gi 822661395 196 REAGLESIETVE 207
Cdd:COG2890  257 EAAGFADVETHK 268
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
83-154 1.56e-08

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 52.98  E-value: 1.56e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 822661395  83 AGDQVLDAGTGTGVLAAYLARVGAE-VRTFEEDPEFAAVARENmdLAEVADRVTVQVGDVTDhLDDASGFDLV 154
Cdd:COG2263   45 EGKTVLDLGCGTGMLAIGAALLGAKkVVGVDIDPEALEIAREN--AERLGVRVDFIRADVTR-IPLGGSVDTV 114
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 87-180 5.89e-08

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 49.35  E-value: 5.89e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822661395  87 VLDAGTGTGVLAAYLAR-VGAEVRTFEEDPEFAAVARENmDLAEVADRVTVQVGDVTDHLDDASG-FDLVTLDTA----- 159
Cdd:cd02440    2 VLDLGCGTGALALALASgPGARVTGVDISPVALELARKA-AAALLADNVEVLKGDAEELPPEADEsFDVIISDPPlhhlv 80

                         90       100
                 ....*....|....*....|..
gi 822661395 160 -DAVPVVERAQDLLVSGGFVAV 180
Cdd:cd02440   81 eDLARFLEEARRLLKPGGVLVL 102
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 67-207 1.93e-07

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 49.56  E-value: 1.93e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822661395  67 MMPKDVGLVIGHTGAAAGDQVLDA--GTGTGVLAAylARVGAEVRTFEEDPEFAAVARENMDLAEVADrVTVQVGDVTD- 143
Cdd:COG1041   10 LDPRLARALVNLAGAKEGDTVLDPfcGTGTILIEA--GLLGRRVIGSDIDPKMVEGARENLEHYGYED-ADVIRGDARDl 86

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 822661395 144 HLDDASgFDLVTLD--------TADAVP------VVERAQDLLVSGGFVAVYSPfvesaREVELAAREAGLESIETVE 207
Cdd:COG1041   87 PLADES-VDAIVTDppygrsskISGEELlelyekALEEAARVLKPGGRVVIVTP-----RDIDELLEEAGFKVLERHE 158
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 72-154 9.67e-07

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 48.62  E-value: 9.67e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822661395  72 VGLVIGHTGAAAGDQVLDAGTGTGVLAAYLA--RVGAEVRTFEEDPEFAAVARENMDLAeVADRVTVQVGDVTDHLDDAS 149
Cdd:PRK09328  97 VEWALEALLLKEPLRVLDLGTGSGAIALALAkeRPDAEVTAVDISPEALAVARRNAKHG-LGARVEFLQGDWFEPLPGGR 175


                 ....*
gi 822661395 150 gFDLV 154
Cdd:PRK09328 176 -FDLI 179
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 69-180 1.22e-06

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 47.60  E-value: 1.22e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822661395  69 PKDVGLVIGHTGAAAGDQVLDAGTGTGVLAAYLA-RVGAEVRTFEEDPEFAAVARENMDLAEvADRVTVQVGDVTDHLD- 146
Cdd:COG0500   12 PGLAALLALLERLPKGGRVLDLGCGTGRNLLALAaRFGGRVIGIDLSPEAIALARARAAKAG-LGNVEFLVADLAELDPl 90

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 822661395 147 DASGFDLVT-------LDTADAVPVVERAQDLLVSGGFVAV 180
Cdd:COG0500   91 PAESFDLVVafgvlhhLPPEEREALLRELARALKPGGVLLL 131
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 88-180 1.32e-06

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 45.35  E-value: 1.32e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822661395   88 LDAGTGTGVLAAYLARVGAEVRTFEEDPEFAAVARENmdlaEVADRVTVQVGDVTDH-LDDASgFDLVTL-----DTADA 161
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGARVTGVDISPEMLELAREK----APREGLTFVVGDAEDLpFPDNS-FDLVLSsevlhHVEDP 75

                          90
                  ....*....|....*....
gi 822661395  162 VPVVERAQDLLVSGGFVAV 180
Cdd:pfam08241  76 ERALREIARVLKPGGILII 94
BchM-ChlM TIGR02021
magnesium protoporphyrin O-methyltransferase; This model represents the ...
 83-157 1.60e-06

magnesium protoporphyrin O-methyltransferase; This model represents the S-adenosylmethionine-dependent O-methyltransferase responsible for methylation of magnesium protoporphyrin IX. This step is essentiasl for the biosynthesis of both chlorophyll and bacteriochlorophyll. This model encompasses two closely related clades, from cyanobacteria (and plants) where it is called ChlM and other photosynthetic bacteria where it is known as BchM. [Biosynthesis of cofactors, prosthetic groups, and carriers, Chlorophyll and bacteriochlorphyll]


Pssm-ID: 273930 [Multi-domain]  Cd Length: 219  Bit Score: 47.49  E-value: 1.60e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 822661395   83 AGDQVLDAGTGTGVLAAYLARVGAEVRTFEEDPEFAAVARENMDLAEVADRVTVQVGDVtdhLDDASGFD-LVTLD 157
Cdd:TIGR02021  55 KGKRVLDAGCGTGLLSIELAKRGAIVKAVDISEQMVQMARNRAQGRDVAGNVEFEVNDL---LSLCGEFDiVVCMD 127
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
75-201 2.18e-06

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 46.53  E-value: 2.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822661395  75 VIGHTGAAAGDQVLDAGTGTGVLAAYLARVGAEVRTFEEDPEFAAVARENmdlaevADRVTVQVGDVTDHLDDASGFDLV 154
Cdd:COG4976   38 LLARLPPGPFGRVLDLGCGTGLLGEALRPRGYRLTGVDLSEEMLAKAREK------GVYDRLLVADLADLAEPDGRFDLI 111

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 822661395 155 T-LDT----ADAVPVVERAQDLLVSGGFVAVYSP-------FVESAREVELAAREAGLE 201
Cdd:COG4976  112 VaADVltylGDLAAVFAGVARALKPGGLFIFSVEdadgsgrYAHSLDYVRDLLAAAGFE 170
PRK07580 PRK07580
Mg-protoporphyrin IX methyl transferase; Validated
 87-154 4.30e-06

Mg-protoporphyrin IX methyl transferase; Validated


Pssm-ID: 236059 [Multi-domain]  Cd Length: 230  Bit Score: 46.37  E-value: 4.30e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 822661395  87 VLDAGTGTGVLAAYLARVGAEVRTFEEDPEFAAVARENMDLAEVADRVTVQVGDvtdhLDDASG-FDLV 154
Cdd:PRK07580  67 ILDAGCGVGSLSIPLARRGAKVVASDISPQMVEEARERAPEAGLAGNITFEVGD----LESLLGrFDTV 131
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 83-183 6.35e-06

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 44.72  E-value: 6.35e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822661395   83 AGDQVLDAGTGTGVL---AAYLARVGAEVRTFEEDPEFAAVARENMDLAEVaDRVTVQVGDVTD---HLDDASgFDLVTL 156
Cdd:pfam13847   3 KGMRVLDLGCGTGHLsfeLAEELGPNAEVVGIDISEEAIEKARENAQKLGF-DNVEFEQGDIEElpeLLEDDK-FDVVIS 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 822661395  157 D-----TADAVPVVERAQDLLVSGGFVAVYSP 183
Cdd:pfam13847  81 NcvlnhIPDPDKVLQEILRVLKPGGRLIISDP 112
PRK14967 PRK14967
putative methyltransferase; Provisional
 79-155 7.36e-06

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 45.43  E-value: 7.36e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 822661395  79 TGAAAGDQVLDAGTGTGVLAAYLARVGAE-VRTFEEDPEFAAVARENMDLAEVadRVTVQVGDVTDHLDDASgFDLVT 155
Cdd:PRK14967  32 EGLGPGRRVLDLCTGSGALAVAAAAAGAGsVTAVDISRRAVRSARLNALLAGV--DVDVRRGDWARAVEFRP-FDVVV 106
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 81-154 9.55e-06

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 44.80  E-value: 9.55e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 822661395  81 AAAGDQVLDAGTGTGVLAAYLARV--GAEVRTFEEDpeFAAV--ARENMDLAEVADrVTVQVGDVTDHLDDASgFDLV 154
Cdd:COG2813   47 EPLGGRVLDLGCGYGVIGLALAKRnpEARVTLVDVN--ARAVelARANAAANGLEN-VEVLWSDGLSGVPDGS-FDLI 120
COG2521 COG2521
Predicted archaeal methyltransferase [General function prediction only];
80-154 1.62e-05

Predicted archaeal methyltransferase [General function prediction only];


Pssm-ID: 442011 [Multi-domain]  Cd Length: 285  Bit Score: 44.90  E-value: 1.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822661395  80 GAAAGDQVLDAGTGTGVLAAYLARVGA-EVRTFEEDPEFAAVARENMDLAEVAD-RVTVQVGDVTDH---LDDASgFDLV 154
Cdd:COG2521  129 GVRRGDRVLDTCTGLGYTAIEALKRGArEVITVEKDPNVLELAELNPWSRELANeRIKIILGDASEViktFPDES-FDAI 207
rADc smart00650
Ribosomal RNA adenine dimethylases;
75-141 4.15e-05

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 42.50  E-value: 4.15e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 822661395    75 VIGHTGAAAGDQVLDAGTGTGVLAAYLARVGAEVRTFEEDPEFAAVAREnmdLAEVADRVTVQVGDV 141
Cdd:smart00650   5 IVRAANLRPGDTVLEIGPGKGALTEELLERAKRVTAIEIDPRLAPRLRE---KFAAADNLTVIHGDA 68
RlmK COG1092
23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure ...
 82-233 4.79e-05

23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure and biogenesis]; 23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 440709 [Multi-domain]  Cd Length: 392  Bit Score: 43.63  E-value: 4.79e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822661395  82 AAGDQVLDAGTGTGVLAAYLARVGA-EVRTFEEDPEFAAVARENMDLAEVADRVTVQVGDVTDHLDDASG----FDLVTL 156
Cdd:COG1092  215 AKGKRVLNLFSYTGGFSVHAAAGGAkSVTSVDLSATALEWAKENAALNGLDDRHEFVQADAFDWLRELARegerFDLIIL 294

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822661395 157 D------TADAVPVVERAQ--------DLLVSGGFVAVYS--------PFVESAREvelAAREAGLEsIETVETIQREMD 214
Cdd:COG1092  295 DppafakSKKDLFDAQRDYkdlnrlalKLLAPGGILVTSScsrhfsldLFLEILAR---AARDAGRR-VRIIERLTQPPD 370

                        170
                 ....*....|....*....
gi 822661395 215 FddrgsrPATRGVGHTGYL 233
Cdd:COG1092  371 H------PVLPAFPEGEYL 383
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 83-207 9.08e-05

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 42.64  E-value: 9.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822661395   83 AGDQVLDAGTGTGVLAAYLARVGA-EVRTFEEDPEFAAVARENMDLAEVADRVTVQV-GDVTDhlddaSGFDLVtldTAD 160
Cdd:pfam06325 161 PGESVLDVGCGSGILAIAALKLGAkKVVGVDIDPVAVRAAKENAELNGVEARLEVYLpGDLPK-----EKADVV---VAN 232

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 822661395  161 --AVPVVERAQD---LLVSGGFVAVYSPFVESAREVeLAAREAGLESIETVE 207
Cdd:pfam06325 233 ilADPLIELAPDiyaLVKPGGYLILSGILKEQAQMV-AEAYSQGFELITVEH 283
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 71-199 1.01e-04

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 41.42  E-value: 1.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822661395   71 DVG--LVIGHTGAAAGDQVLDAGTGTGVLAAYLARVGAEVRT--FEEDPEFAAVARENMdLAEVADRVTVQVGDVTDHLD 146
Cdd:pfam05175  17 DIGsrLLLEHLPKDLSGKVLDLGCGAGVLGAALAKESPDAELtmVDINARALESARENL-AANGLENGEVVASDVYSGVE 95

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 822661395  147 DASgFDLV------------TLDTADAvpVVERAQDLLVSGG---FVAV----YSPFVESA-REVELAAREAG 199
Cdd:pfam05175  96 DGK-FDLIisnppfhaglatTYNVAQR--FIADAKRHLRPGGelwIVANrflgYPPLLEELfGNVEVVAKTNG 165
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
83-176 3.06e-04

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 40.43  E-value: 3.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822661395   83 AGDQVLDAGTGTGVLAAYLAR-VGAE--VRTFEEDPEFAAVARENMDlAEVADRVTVQVGDVTDHLDDASGFDlVTLDTA 159
Cdd:pfam01135  73 PGMRVLEIGSGSGYLTACFARmVGEVgrVVSIEHIPELVEIARRNLE-KLGLENVIVVVGDGRQGWPEFAPYD-AIHVGA 150

                          90
                  ....*....|....*...
gi 822661395  160 dAVPVVERA-QDLLVSGG 176
Cdd:pfam01135 151 -AAPEIPEAlIDQLKEGG 167
PRK14968 PRK14968
putative methyltransferase; Provisional
 83-155 4.04e-04

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 39.88  E-value: 4.04e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 822661395  83 AGDQVLDAGTGTGVLAAYLARVGAEVRTFEEDPEFAAVARENMDLAEVADR-VTVQVGDVTDHLDDASgFDLVT 155
Cdd:PRK14968  23 KGDRVLEVGTGSGIVAIVAAKNGKKVVGVDINPYAVECAKCNAKLNNIRNNgVEVIRSDLFEPFRGDK-FDVIL 95
RsmA COG0030
16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase ...
 83-144 5.25e-04

16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) [Translation, ribosomal structure and biogenesis]; 16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439801 [Multi-domain]  Cd Length: 270  Bit Score: 40.11  E-value: 5.25e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 822661395  83 AGDQVLDAGTGTGVLAAYLARVGAEVRTFEEDPEFAAVARENmdlAEVADRVTVQVGDVTDH 144
Cdd:COG0030   37 PGDTVLEIGPGLGALTRALLERAARVTAVEIDRRLAAILRET---FAAYPNLTVIEGDALKV 95
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 75-155 6.23e-04

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 39.75  E-value: 6.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822661395  75 VIGHTGAAAGDQVLDAGTGTGVLAAYLAR-VGAEVRTFEEDPEFA--AVARENMDLAEVADRVTVQVGDVTdHL--DDAS 149
Cdd:PRK00216  43 TIKWLGVRPGDKVLDLACGTGDLAIALAKaVGKTGEVVGLDFSEGmlAVGREKLRDLGLSGNVEFVQGDAE-ALpfPDNS 121


                 ....*.
gi 822661395 150 gFDLVT 155
Cdd:PRK00216 122 -FDAVT 126
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 88-178 8.93e-04

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 37.73  E-value: 8.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822661395   88 LDAGTGTGVLAAYLAR--VGAEVRTFEEDPEFAAVARENMDLAEVADRVTVQVGDVTDHLDDASGFDLVTL-----DTAD 160
Cdd:pfam08242   1 LEIGCGTGTLLRALLEalPGLEYTGLDISPAALEAARERLAALGLLNAVRVELFQLDLGELDPGSFDVVVAsnvlhHLAD 80

                          90
                  ....*....|....*...
gi 822661395  161 AVPVVERAQDLLVSGGFV 178
Cdd:pfam08242  81 PRAVLRNIRRLLKPGGVL 98
PLN02244 PLN02244
tocopherol O-methyltransferase
 87-154 2.09e-03

tocopherol O-methyltransferase


Pssm-ID: 215135 [Multi-domain]  Cd Length: 340  Bit Score: 38.57  E-value: 2.09e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 822661395  87 VLDAGTGTGVLAAYLAR-VGAEVRTFEEDPEFAAVARENMDLAEVADRVTVQVGDVTDHLDDASGFDLV 154
Cdd:PLN02244 122 IVDVGCGIGGSSRYLARkYGANVKGITLSPVQAARANALAAAQGLSDKVSFQVADALNQPFEDGQFDLV 190
hemK_rel_arch TIGR00537
HemK-related putative methylase; The gene hemK from E. coli was found to contribute to heme ...
 84-171 6.83e-03

HemK-related putative methylase; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. This model represents an archaeal and eukaryotic protein family that lacks an N-terminal domain found in HemK and its eubacterial homologs. It is found in a single copy in the first six completed archaeal and eukaryotic genomes. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 129628 [Multi-domain]  Cd Length: 179  Bit Score: 36.37  E-value: 6.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822661395   84 GDQVLDAGTGTGVLAAYLARVGAEVRTFEEDPEFAAVARENMDLAEVADRVTvqvgdVTDHLDDASG-FDLVTLDTadav 162
Cdd:TIGR00537  20 PDDVLEIGAGTGLVAIRLKGKGKCILTTDINPFAVKELRENAKLNNVGLDVV-----MTDLFKGVRGkFDVILFNP---- 90


                  ....*....
gi 822661395  163 PVVERAQDL 171
Cdd:TIGR00537  91 PYLPLEDDL 99
pcm PRK00312
protein-L-isoaspartate(D-aspartate) O-methyltransferase;
54-176 8.56e-03

protein-L-isoaspartate(D-aspartate) O-methyltransferase;


Pssm-ID: 178974 [Multi-domain]  Cd Length: 212  Bit Score: 36.34  E-value: 8.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822661395  54 PDLFQHL--ERTGAPMM-------PKDVGLVIGHTGAAAGDQVLDAGTGTGVLAAYLARVGAEVRTFEEDPEFAAVAREN 124
Cdd:PRK00312  40 PEAFKHKayENRALPIGcgqtisqPYMVARMTELLELKPGDRVLEIGTGSGYQAAVLAHLVRRVFSVERIKTLQWEAKRR 119

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 822661395 125 MDLAEVaDRVTVQVGDVTDHLDDASGFD--LVTLdTADAVPvvERAQDLLVSGG 176
Cdd:PRK00312 120 LKQLGL-HNVSVRHGDGWKGWPAYAPFDriLVTA-AAPEIP--RALLEQLKEGG 169
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
83-154 9.50e-03

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 36.28  E-value: 9.50e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 822661395  83 AGDQVLDAGTGTGVLAAYLARVGA-EVRTFEEDPEFAAVARENMDLAEVADRVTVQvgdvtdhlDDASGFDLV 154
Cdd:PRK00517 119 PGKTVLDVGCGSGILAIAAAKLGAkKVLAVDIDPQAVEAARENAELNGVELNVYLP--------QGDLKADVI 183
cbiT PRK00377
cobalt-precorrin-6Y C(15)-methyltransferase; Provisional
 84-209 9.54e-03

cobalt-precorrin-6Y C(15)-methyltransferase; Provisional


Pssm-ID: 234740  Cd Length: 198  Bit Score: 35.93  E-value: 9.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 822661395  84 GDQVLDAGTGTG---VLAAYLARVGAEVRTFEEDPEFAAVARENMDLAEVADRVTVQVGD---VTDHLDDASGFDLVTLD 157
Cdd:PRK00377  41 GDMILDIGCGTGsvtVEASLLVGETGKVYAVDKDEKAINLTRRNAEKFGVLNNIVLIKGEapeILFTINEKFDRIFIGGG 120

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 822661395 158 TADAVPVVERAQDLLVSGGFVAVYSPFVESAREVELAAREAGLEsIETVETI 209
Cdd:PRK00377 121 SEKLKEIISASWEIIKKGGRIVIDAILLETVNNALSALENIGFN-LEITEVI 171
rsmC PRK09489
16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;
87-154 9.75e-03

16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;


Pssm-ID: 181902 [Multi-domain]  Cd Length: 342  Bit Score: 36.45  E-value: 9.75e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 822661395  87 VLDAGTGTGVLAAYLARVGAEVRTFEEDPEFAAVARENMDLAEVADRVTVQVGDVTDHLDDAsgFDLV 154
Cdd:PRK09489 200 VLDVGCGAGVLSAVLARHSPKIRLTLSDVSAAALESSRATLAANGLEGEVFASNVFSDIKGR--FDMI 265
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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