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Conserved domains on  [gi|785798227|gb|AKA12604|]
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hemolysin [Mannheimia haemolytica]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RTX_toxin super family cl41537
RTX family hemolysin; RTX family toxin are secreted from the bacteria and inserted into the ...
 44-923 0e+00

RTX family hemolysin; RTX family toxin are secreted from the bacteria and inserted into the membranes of infected cells, causing host cell rupture.


The actual alignment was detected with superfamily member NF033943:

Pssm-ID: 468257 [Multi-domain]  Cd Length: 875  Bit Score: 1330.84  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 785798227  44 IILYIPQNYqyDTEQGNGLQDLVKAAEELGIEVQREERNNIATAQTSLGTIQTAIGLTERGIVLSAPQIDKLLQKT-KAG 122
Cdd:NF033943   1 LILLIPKDY--DGQKGNGLNDLVKAADELGIEVQREERNNTAIAKKSFGTAEKLLGLTERGVVIFAPQLDKLLQKYsKIG 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 785798227 123 QALG-SAESIVQNANKAKTVLSGIQSILGSVLAGMDLDEALQ--NNSNQHALAKAGLELTNSLIENIANSVKTLDEFGEQ 199
Cdd:NF033943  79 NGLGsSAENIGNNLGKAQTVLSTIQSFLGTALAGMELDELIKkgEDVSQLELAKASIELINELVDNIASSNQTIDAFSEQ 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 785798227 200 ISQFGSKLQNIKGLGTLGDKLKNIGGLDKAGLGLDVISGLLSGATAALVLADKNASTAKKVGAGFELANQVVGNITKAVS 279
Cdd:NF033943 159 LNKLGSLLSNAKGLGGLGNKLQNLPNLSKAGLGLDVISGLLSGISAGFILADKNASTGTKVAAGFELTNQVLGNVTKAVS 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 785798227 280 SYILAQRVAAGLSSTGPVAALIASTVSLAISPLAFAGIADKFNHAKSLESYAERFKKLGYDGDNLLAEYQRGTGTIDASV 359
Cdd:NF033943 239 SYILAQRVAAGLSTTGAVAALIASAVSLAISPLAFLSIADKFNRAKQLEEYSERFKKLGYDGDSLLAEFQRETGTIDASL 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 785798227 360 TAINTALAAIAGGVSAAAAGSVIASPIALLVSGITGVISTILQYSKQAMFEHVANKIHNKIVEWEKnNHGKNYFENGYDA 439
Cdd:NF033943 319 TTINTALSAISAGVSAAAAGSLVGAPIALLVSGITGLISGILEASKQAMFEHVANKLANKIAEWEK-KNGKNYFENGYDA 397

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 785798227 440 RYLANLQDNMKFLLNLNKELQAERVIAITQQQWDNNIGDLAGISRLGEKVLSGKAYVDAFEEGKHIKAD----KLVQLDS 515
Cdd:NF033943 398 RHAAFLEDNFKLLSSLNKEYQVERAVAITQQRWDENIGELAGITKNGDKISSGKAYVDYFEEGKRLEKKpdefSKVVFDP 477

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 785798227 516 ANGIIDVSNSgkAKTQHILFRTPLLTPGTEHRERVQTGKYEYITKLNINRVDSWKITD-GAASSTFDLTNVVQRIGIELd 594
Cdd:NF033943 478 LKGIIDISNS--KKSTLLKFVTPLLTPGEESRERKQSGKYEYITKLVVNGVDKWTVKGvGNAGSVYDYSNLIQHAAIES- 554

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 785798227 595 nagnvTKTKETKIIAKLGEGDDNVFVGSGTTEIDGGEGYDRVHYSRGNYGALTIDATKETEQGSYTVNRFV-ETGKALHE 673
Cdd:NF033943 555 -----GKYREIRIISNLGAGNDKVFVGAGSSNIDAGEGHDRVYYSKTDTGYLTIDGTKATEAGSYTVTRELgGDVKILHE 629

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 785798227 674 VTSTHTALVGNREEKIEYRHSN-NQHHAGYYTKDTLKAVEEIIGTSHNDIFKGSKFNDAFNGGDGVDTIDGNDGNDRLFG 752
Cdd:NF033943 630 VVKEQETSVGKRTEKIQYRDYElRSGGYGYTATDTLKSVEEIIGSNRNDKFKGSKFNDIFHGADGDDTIEGNDGDDRLYG 709

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 785798227 753 GKGDDILDGGNGDDFIDGGKGNDLLHGGKGDDIFVHRKGDGNDIITDSDG-NDKLSFSDSNLKDLTFEKVKHNLVITNSK 831
Cdd:NF033943 710 GKGDDKLYGGEGDDLLDGGEGNDYLNGGYGNDIYIYRKGYGNHTIYDSGGkNDKLSLSDISLSDLTFKRVGNDLIINKND 789

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 785798227 832 ---KEKVTIQNWFReadfaKEVPNYkatKDEKIEEIIGQNGERITSKQVDDLIAKGNGKITQDELSKVVDNYELLKHSKn 908
Cdd:NF033943 790 ngvKNGITIKNWFK-----KESGNK---KNHKIEQIIDKDGRVITSDQIDKLLKKKNGKISYILLSKLADNYNESNLSS- 860

                        890
                 ....*....|....*
gi 785798227 909 VTNSLDKLISSVSAF 923
Cdd:NF033943 861 LANSLSKIISSAGSF 875
 
Name Accession Description Interval E-value
RTX_toxin NF033943
RTX family hemolysin; RTX family toxin are secreted from the bacteria and inserted into the ...
 44-923 0e+00

RTX family hemolysin; RTX family toxin are secreted from the bacteria and inserted into the membranes of infected cells, causing host cell rupture.


Pssm-ID: 468257 [Multi-domain]  Cd Length: 875  Bit Score: 1330.84  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 785798227  44 IILYIPQNYqyDTEQGNGLQDLVKAAEELGIEVQREERNNIATAQTSLGTIQTAIGLTERGIVLSAPQIDKLLQKT-KAG 122
Cdd:NF033943   1 LILLIPKDY--DGQKGNGLNDLVKAADELGIEVQREERNNTAIAKKSFGTAEKLLGLTERGVVIFAPQLDKLLQKYsKIG 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 785798227 123 QALG-SAESIVQNANKAKTVLSGIQSILGSVLAGMDLDEALQ--NNSNQHALAKAGLELTNSLIENIANSVKTLDEFGEQ 199
Cdd:NF033943  79 NGLGsSAENIGNNLGKAQTVLSTIQSFLGTALAGMELDELIKkgEDVSQLELAKASIELINELVDNIASSNQTIDAFSEQ 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 785798227 200 ISQFGSKLQNIKGLGTLGDKLKNIGGLDKAGLGLDVISGLLSGATAALVLADKNASTAKKVGAGFELANQVVGNITKAVS 279
Cdd:NF033943 159 LNKLGSLLSNAKGLGGLGNKLQNLPNLSKAGLGLDVISGLLSGISAGFILADKNASTGTKVAAGFELTNQVLGNVTKAVS 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 785798227 280 SYILAQRVAAGLSSTGPVAALIASTVSLAISPLAFAGIADKFNHAKSLESYAERFKKLGYDGDNLLAEYQRGTGTIDASV 359
Cdd:NF033943 239 SYILAQRVAAGLSTTGAVAALIASAVSLAISPLAFLSIADKFNRAKQLEEYSERFKKLGYDGDSLLAEFQRETGTIDASL 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 785798227 360 TAINTALAAIAGGVSAAAAGSVIASPIALLVSGITGVISTILQYSKQAMFEHVANKIHNKIVEWEKnNHGKNYFENGYDA 439
Cdd:NF033943 319 TTINTALSAISAGVSAAAAGSLVGAPIALLVSGITGLISGILEASKQAMFEHVANKLANKIAEWEK-KNGKNYFENGYDA 397

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 785798227 440 RYLANLQDNMKFLLNLNKELQAERVIAITQQQWDNNIGDLAGISRLGEKVLSGKAYVDAFEEGKHIKAD----KLVQLDS 515
Cdd:NF033943 398 RHAAFLEDNFKLLSSLNKEYQVERAVAITQQRWDENIGELAGITKNGDKISSGKAYVDYFEEGKRLEKKpdefSKVVFDP 477

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 785798227 516 ANGIIDVSNSgkAKTQHILFRTPLLTPGTEHRERVQTGKYEYITKLNINRVDSWKITD-GAASSTFDLTNVVQRIGIELd 594
Cdd:NF033943 478 LKGIIDISNS--KKSTLLKFVTPLLTPGEESRERKQSGKYEYITKLVVNGVDKWTVKGvGNAGSVYDYSNLIQHAAIES- 554

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 785798227 595 nagnvTKTKETKIIAKLGEGDDNVFVGSGTTEIDGGEGYDRVHYSRGNYGALTIDATKETEQGSYTVNRFV-ETGKALHE 673
Cdd:NF033943 555 -----GKYREIRIISNLGAGNDKVFVGAGSSNIDAGEGHDRVYYSKTDTGYLTIDGTKATEAGSYTVTRELgGDVKILHE 629

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 785798227 674 VTSTHTALVGNREEKIEYRHSN-NQHHAGYYTKDTLKAVEEIIGTSHNDIFKGSKFNDAFNGGDGVDTIDGNDGNDRLFG 752
Cdd:NF033943 630 VVKEQETSVGKRTEKIQYRDYElRSGGYGYTATDTLKSVEEIIGSNRNDKFKGSKFNDIFHGADGDDTIEGNDGDDRLYG 709

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 785798227 753 GKGDDILDGGNGDDFIDGGKGNDLLHGGKGDDIFVHRKGDGNDIITDSDG-NDKLSFSDSNLKDLTFEKVKHNLVITNSK 831
Cdd:NF033943 710 GKGDDKLYGGEGDDLLDGGEGNDYLNGGYGNDIYIYRKGYGNHTIYDSGGkNDKLSLSDISLSDLTFKRVGNDLIINKND 789

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 785798227 832 ---KEKVTIQNWFReadfaKEVPNYkatKDEKIEEIIGQNGERITSKQVDDLIAKGNGKITQDELSKVVDNYELLKHSKn 908
Cdd:NF033943 790 ngvKNGITIKNWFK-----KESGNK---KNHKIEQIIDKDGRVITSDQIDKLLKKKNGKISYILLSKLADNYNESNLSS- 860

                        890
                 ....*....|....*
gi 785798227 909 VTNSLDKLISSVSAF 923
Cdd:NF033943 861 LANSLSKIISSAGSF 875
RTX pfam02382
N-terminal domain in RTX protein; The RTX family of bacterial toxins are a group of cytolysins ...
 283-589 3.47e-134

N-terminal domain in RTX protein; The RTX family of bacterial toxins are a group of cytolysins and cytotoxins that have RTX (Repeat in ToXin repeats) pfam00353. This Pfam family represents a presumed domain which in some of these proteins.


Pssm-ID: 396797  Cd Length: 312  Bit Score: 404.95  E-value: 3.47e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 785798227  283 LAQRVAAGLSSTGPVAALI---ASTVSLAISPLAFAGIADKFNHAKSLESYAERFKKLGYDGDNLLAEYQRGTGTIDASV 359
Cdd:pfam02382   1 LAQRAAAGLATTGAVAVLIlgiTASLALAISPLEWAAFAQKFDYADDLDKLAQEFSDFGYEGDGLLAELLRGKGTIEASF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 785798227  360 TAINTALAAIAGGVSAAAAGSVIASPIALLVSGITGVISTILQYSKQAMFEHVANKIHNKIVewEKNNHGKNYFENGYDA 439
Cdd:pfam02382  81 YAISTALGVVSGGVSAAAAASGVGAPIALLVAGITGGISGILEASKQAMLEKVANRYAEKIR--AKNNGVQAYFENSFDA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 785798227  440 RYLANLQDNMKFLLNLNKELQAERVIAITQQQWDNNIGDLAGISRLGEKVLSGKAYVDAFEEGKHIKADK----LVQLDS 515
Cdd:pfam02382 159 RHEALLEDNTKFLAELIKELNADRVIALGQQQWDANDGELAGISKLGGELKSGKAYVDAFEEGAKLEAGSwnteNIQLDA 238

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 785798227  516 ANGIIDVSNSGKAKTQHILFRTPLLTPGTEHRERVQTGKYEYITKLNINRVDSWKITDGAASSTFDLTNVVQRI 589
Cdd:pfam02382 239 ATGVIDISNVNGAKTQALTFTTPLLAAGTETRSRVHTGKNEYITTLKINRLKGWTIKDGGANSTFDLSKVVQKA 312
COG2931 COG2931
Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and ...
 714-812 6.60e-15

Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442175 [Multi-domain]  Cd Length: 252  Bit Score: 75.71  E-value: 6.60e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 785798227 714 IIGTSHNDIFKGSKFNDAFNGGDGVDTIDGNDGNDRLFGGKGDDILDGGNGDDFIDGGKGNDLLHGGKGDDIFVhrKGDG 793
Cdd:COG2931  115 LTGGDGNDTLTGGAGDDTLYGGAGNDTLTGGAGNDTLYGGAGNDTLYGGAGNDTLDGGAGNDTLTGGAGNDTLT--GGAG 192

                         90
                 ....*....|....*....
gi 785798227 794 NDIITDSDGNDKLSFSDSN 812
Cdd:COG2931  193 NDTLDGGGGDDTLGGGGGD 211
 
Name Accession Description Interval E-value
RTX_toxin NF033943
RTX family hemolysin; RTX family toxin are secreted from the bacteria and inserted into the ...
 44-923 0e+00

RTX family hemolysin; RTX family toxin are secreted from the bacteria and inserted into the membranes of infected cells, causing host cell rupture.


Pssm-ID: 468257 [Multi-domain]  Cd Length: 875  Bit Score: 1330.84  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 785798227  44 IILYIPQNYqyDTEQGNGLQDLVKAAEELGIEVQREERNNIATAQTSLGTIQTAIGLTERGIVLSAPQIDKLLQKT-KAG 122
Cdd:NF033943   1 LILLIPKDY--DGQKGNGLNDLVKAADELGIEVQREERNNTAIAKKSFGTAEKLLGLTERGVVIFAPQLDKLLQKYsKIG 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 785798227 123 QALG-SAESIVQNANKAKTVLSGIQSILGSVLAGMDLDEALQ--NNSNQHALAKAGLELTNSLIENIANSVKTLDEFGEQ 199
Cdd:NF033943  79 NGLGsSAENIGNNLGKAQTVLSTIQSFLGTALAGMELDELIKkgEDVSQLELAKASIELINELVDNIASSNQTIDAFSEQ 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 785798227 200 ISQFGSKLQNIKGLGTLGDKLKNIGGLDKAGLGLDVISGLLSGATAALVLADKNASTAKKVGAGFELANQVVGNITKAVS 279
Cdd:NF033943 159 LNKLGSLLSNAKGLGGLGNKLQNLPNLSKAGLGLDVISGLLSGISAGFILADKNASTGTKVAAGFELTNQVLGNVTKAVS 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 785798227 280 SYILAQRVAAGLSSTGPVAALIASTVSLAISPLAFAGIADKFNHAKSLESYAERFKKLGYDGDNLLAEYQRGTGTIDASV 359
Cdd:NF033943 239 SYILAQRVAAGLSTTGAVAALIASAVSLAISPLAFLSIADKFNRAKQLEEYSERFKKLGYDGDSLLAEFQRETGTIDASL 318

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 785798227 360 TAINTALAAIAGGVSAAAAGSVIASPIALLVSGITGVISTILQYSKQAMFEHVANKIHNKIVEWEKnNHGKNYFENGYDA 439
Cdd:NF033943 319 TTINTALSAISAGVSAAAAGSLVGAPIALLVSGITGLISGILEASKQAMFEHVANKLANKIAEWEK-KNGKNYFENGYDA 397

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 785798227 440 RYLANLQDNMKFLLNLNKELQAERVIAITQQQWDNNIGDLAGISRLGEKVLSGKAYVDAFEEGKHIKAD----KLVQLDS 515
Cdd:NF033943 398 RHAAFLEDNFKLLSSLNKEYQVERAVAITQQRWDENIGELAGITKNGDKISSGKAYVDYFEEGKRLEKKpdefSKVVFDP 477

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 785798227 516 ANGIIDVSNSgkAKTQHILFRTPLLTPGTEHRERVQTGKYEYITKLNINRVDSWKITD-GAASSTFDLTNVVQRIGIELd 594
Cdd:NF033943 478 LKGIIDISNS--KKSTLLKFVTPLLTPGEESRERKQSGKYEYITKLVVNGVDKWTVKGvGNAGSVYDYSNLIQHAAIES- 554

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 785798227 595 nagnvTKTKETKIIAKLGEGDDNVFVGSGTTEIDGGEGYDRVHYSRGNYGALTIDATKETEQGSYTVNRFV-ETGKALHE 673
Cdd:NF033943 555 -----GKYREIRIISNLGAGNDKVFVGAGSSNIDAGEGHDRVYYSKTDTGYLTIDGTKATEAGSYTVTRELgGDVKILHE 629

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 785798227 674 VTSTHTALVGNREEKIEYRHSN-NQHHAGYYTKDTLKAVEEIIGTSHNDIFKGSKFNDAFNGGDGVDTIDGNDGNDRLFG 752
Cdd:NF033943 630 VVKEQETSVGKRTEKIQYRDYElRSGGYGYTATDTLKSVEEIIGSNRNDKFKGSKFNDIFHGADGDDTIEGNDGDDRLYG 709

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 785798227 753 GKGDDILDGGNGDDFIDGGKGNDLLHGGKGDDIFVHRKGDGNDIITDSDG-NDKLSFSDSNLKDLTFEKVKHNLVITNSK 831
Cdd:NF033943 710 GKGDDKLYGGEGDDLLDGGEGNDYLNGGYGNDIYIYRKGYGNHTIYDSGGkNDKLSLSDISLSDLTFKRVGNDLIINKND 789

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 785798227 832 ---KEKVTIQNWFReadfaKEVPNYkatKDEKIEEIIGQNGERITSKQVDDLIAKGNGKITQDELSKVVDNYELLKHSKn 908
Cdd:NF033943 790 ngvKNGITIKNWFK-----KESGNK---KNHKIEQIIDKDGRVITSDQIDKLLKKKNGKISYILLSKLADNYNESNLSS- 860

                        890
                 ....*....|....*
gi 785798227 909 VTNSLDKLISSVSAF 923
Cdd:NF033943 861 LANSLSKIISSAGSF 875
RTX pfam02382
N-terminal domain in RTX protein; The RTX family of bacterial toxins are a group of cytolysins ...
 283-589 3.47e-134

N-terminal domain in RTX protein; The RTX family of bacterial toxins are a group of cytolysins and cytotoxins that have RTX (Repeat in ToXin repeats) pfam00353. This Pfam family represents a presumed domain which in some of these proteins.


Pssm-ID: 396797  Cd Length: 312  Bit Score: 404.95  E-value: 3.47e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 785798227  283 LAQRVAAGLSSTGPVAALI---ASTVSLAISPLAFAGIADKFNHAKSLESYAERFKKLGYDGDNLLAEYQRGTGTIDASV 359
Cdd:pfam02382   1 LAQRAAAGLATTGAVAVLIlgiTASLALAISPLEWAAFAQKFDYADDLDKLAQEFSDFGYEGDGLLAELLRGKGTIEASF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 785798227  360 TAINTALAAIAGGVSAAAAGSVIASPIALLVSGITGVISTILQYSKQAMFEHVANKIHNKIVewEKNNHGKNYFENGYDA 439
Cdd:pfam02382  81 YAISTALGVVSGGVSAAAAASGVGAPIALLVAGITGGISGILEASKQAMLEKVANRYAEKIR--AKNNGVQAYFENSFDA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 785798227  440 RYLANLQDNMKFLLNLNKELQAERVIAITQQQWDNNIGDLAGISRLGEKVLSGKAYVDAFEEGKHIKADK----LVQLDS 515
Cdd:pfam02382 159 RHEALLEDNTKFLAELIKELNADRVIALGQQQWDANDGELAGISKLGGELKSGKAYVDAFEEGAKLEAGSwnteNIQLDA 238

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 785798227  516 ANGIIDVSNSGKAKTQHILFRTPLLTPGTEHRERVQTGKYEYITKLNINRVDSWKITDGAASSTFDLTNVVQRI 589
Cdd:pfam02382 239 ATGVIDISNVNGAKTQALTFTTPLLAAGTETRSRVHTGKNEYITTLKINRLKGWTIKDGGANSTFDLSKVVQKA 312
RTX_C pfam08339
RTX C-terminal domain; This family describes the C-terminal region of various bacterial ...
 807-938 1.30e-40

RTX C-terminal domain; This family describes the C-terminal region of various bacterial haemolysins and leukotoxins, which belong to the RTX family of toxins. These are produced by various Gram negative bacteria, such as E. coli and Actinobacillus pleuropneumoniae. RTX toxins may interact with lipopolysaccharide (LPS) to functionally impair and eventually kill leukocytes. This region is found in association with the RTX N-terminal domain (pfam02382) and multiple hemolysin-type calcium-binding repeats (pfam00353).


Pssm-ID: 429930  Cd Length: 131  Bit Score: 145.81  E-value: 1.30e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 785798227  807 SFSDSNLKDLTFEKVKHNLVIT-NSKKEKVTIQNWFReadfAKEVPNYKATK-DEKIEEIIGQNGERITSKQVDDLIA-K 883
Cdd:pfam08339   1 AFSDANLSDLTFERVGNGLIIKkNDDSGSITFKNWFA----ALSRPNYHASGtDDKIEEIIGKNGRYITSEQVDKLLNnK 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 785798227  884 GNGKITQDELSKVVDNYELLKHSKNVTNSLDKLISSVSAFTSSNDSRNVLVAPTS 938
Cdd:pfam08339  77 QSGKITSSQLQQLAQNKSNMINSTDVANSLNKLISSMSGFGSQNNTHSNTLQPTV 131
COG2931 COG2931
Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and ...
 714-812 6.60e-15

Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442175 [Multi-domain]  Cd Length: 252  Bit Score: 75.71  E-value: 6.60e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 785798227 714 IIGTSHNDIFKGSKFNDAFNGGDGVDTIDGNDGNDRLFGGKGDDILDGGNGDDFIDGGKGNDLLHGGKGDDIFVhrKGDG 793
Cdd:COG2931  115 LTGGDGNDTLTGGAGDDTLYGGAGNDTLTGGAGNDTLYGGAGNDTLYGGAGNDTLDGGAGNDTLTGGAGNDTLT--GGAG 192

                         90
                 ....*....|....*....
gi 785798227 794 NDIITDSDGNDKLSFSDSN 812
Cdd:COG2931  193 NDTLDGGGGDDTLGGGGGD 211
COG2931 COG2931
Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and ...
 714-812 2.99e-14

Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442175 [Multi-domain]  Cd Length: 252  Bit Score: 73.79  E-value: 2.99e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 785798227 714 IIGTSHNDIFKGSKFNDAFNGGDGVDTIDGNDGNDRLFGGKGDDILDGGNGDDFIDGGKGNDLLHGGKGDDIFVHrkGDG 793
Cdd:COG2931  106 GDGGGGNDTLTGGDGNDTLTGGAGDDTLYGGAGNDTLTGGAGNDTLYGGAGNDTLYGGAGNDTLDGGAGNDTLTG--GAG 183

                         90
                 ....*....|....*....
gi 785798227 794 NDIITDSDGNDKLSFSDSN 812
Cdd:COG2931  184 NDTLTGGAGNDTLDGGGGD 202
COG2931 COG2931
Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and ...
 714-812 7.04e-12

Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442175 [Multi-domain]  Cd Length: 252  Bit Score: 66.85  E-value: 7.04e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 785798227 714 IIGTSHNDIFKGSKFNDAFNGGDGVDTIDGNDGNDRLFGGKGDDILDGGNGDDFIDGGKGNDLLHGGKGDDIFVHrkGDG 793
Cdd:COG2931  133 LYGGAGNDTLTGGAGNDTLYGGAGNDTLYGGAGNDTLDGGAGNDTLTGGAGNDTLTGGAGNDTLDGGGGDDTLGG--GGG 210

                         90
                 ....*....|....*....
gi 785798227 794 NDIITDSDGNDKLSFSDSN 812
Cdd:COG2931  211 DDGLDGGDGDDGLGGGGGD 229
HemolysinCabind pfam00353
RTX calcium-binding nonapeptide repeat (4 copies);
742-777 3.21e-10

RTX calcium-binding nonapeptide repeat (4 copies);


Pssm-ID: 459777 [Multi-domain]  Cd Length: 36  Bit Score: 55.91  E-value: 3.21e-10
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 785798227  742 DGNDGNDRLFGGKGDDILDGGNGDDFIDGGKGNDLL 777
Cdd:pfam00353   1 YGGDGNDTLVGGAGNDTIYGGAGNDTLDGGAGNDTL 36
HemolysinCabind pfam00353
RTX calcium-binding nonapeptide repeat (4 copies);
734-768 1.90e-09

RTX calcium-binding nonapeptide repeat (4 copies);


Pssm-ID: 459777 [Multi-domain]  Cd Length: 36  Bit Score: 53.60  E-value: 1.90e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 785798227  734 GGDGVDTIDGNDGNDRLFGGKGDDILDGGNGDDFI 768
Cdd:pfam00353   2 GGDGNDTLVGGAGNDTIYGGAGNDTLDGGAGNDTL 36
Peptidase_M10_C pfam08548
Peptidase M10 serralysin C terminal; Serralysins are peptidases related to mammalian matrix ...
 743-812 1.25e-08

Peptidase M10 serralysin C terminal; Serralysins are peptidases related to mammalian matrix metallopeptidases (MMPs). The peptidase unit is found at the N terminal while this domain at the C terminal forms a corkscrew and is thought to be important for secretion of the protein through the bacterial cell wall. This domain contains the calcium ion binding domain pfam00353.


Pssm-ID: 430067 [Multi-domain]  Cd Length: 222  Bit Score: 56.23  E-value: 1.25e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 785798227  743 GNDGNDRLFGGKGDDILDGGNGDDFIDGGKGNDLLHGGKGDDIFVHRKGD-----GNDIITD-SDGNDKLSFSDSN 812
Cdd:pfam08548  86 GGSGNDVLIGNDADNILKGGAGNDILYGGGGADQLWGGAGNDIFVYASAKdsltaAPDTIRDfVSGIDKIDLSALN 161
HemolysinCabind pfam00353
RTX calcium-binding nonapeptide repeat (4 copies);
751-786 2.18e-08

RTX calcium-binding nonapeptide repeat (4 copies);


Pssm-ID: 459777 [Multi-domain]  Cd Length: 36  Bit Score: 50.51  E-value: 2.18e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 785798227  751 FGGKGDDILDGGNGDDFIDGGKGNDLLHGGKGDDIF 786
Cdd:pfam00353   1 YGGDGNDTLVGGAGNDTIYGGAGNDTLDGGAGNDTL 36
HemolysinCabind pfam00353
RTX calcium-binding nonapeptide repeat (4 copies);
760-797 2.09e-06

RTX calcium-binding nonapeptide repeat (4 copies);


Pssm-ID: 459777 [Multi-domain]  Cd Length: 36  Bit Score: 45.12  E-value: 2.09e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 785798227  760 DGGNGDDFIDGGKGNDLLHGGKGDDIFVHrkGDGNDII 797
Cdd:pfam00353   1 YGGDGNDTLVGGAGNDTIYGGAGNDTLDG--GAGNDTL 36
COG2931 COG2931
Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and ...
 714-804 2.85e-06

Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442175 [Multi-domain]  Cd Length: 252  Bit Score: 49.90  E-value: 2.85e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 785798227 714 IIGTSHNDIFKGSKFNDAFNGGDGVDTIDGNDGNDRLFGGKGDDILDGGNGDDFIDGGKGNDLLHGGKGDDIFVHRKGDG 793
Cdd:COG2931  160 LYGGAGNDTLDGGAGNDTLTGGAGNDTLTGGAGNDTLDGGGGDDTLGGGGGDDGLDGGDGDDGLGGGGGDDTLGGGGGGD 239

                         90
                 ....*....|.
gi 785798227 794 NDIITDSDGND 804
Cdd:COG2931  240 GGGGGGGDDGL 250
HemolysinCabind pfam00353
RTX calcium-binding nonapeptide repeat (4 copies);
725-759 3.88e-06

RTX calcium-binding nonapeptide repeat (4 copies);


Pssm-ID: 459777 [Multi-domain]  Cd Length: 36  Bit Score: 44.35  E-value: 3.88e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 785798227  725 GSKFNDAFNGGDGVDTIDGNDGNDRLFGGKGDDIL 759
Cdd:pfam00353   2 GGDGNDTLVGGAGNDTIYGGAGNDTLDGGAGNDTL 36
Peptidase_M10_C pfam08548
Peptidase M10 serralysin C terminal; Serralysins are peptidases related to mammalian matrix ...
 751-815 2.85e-05

Peptidase M10 serralysin C terminal; Serralysins are peptidases related to mammalian matrix metallopeptidases (MMPs). The peptidase unit is found at the N terminal while this domain at the C terminal forms a corkscrew and is thought to be important for secretion of the protein through the bacterial cell wall. This domain contains the calcium ion binding domain pfam00353.


Pssm-ID: 430067 [Multi-domain]  Cd Length: 222  Bit Score: 46.21  E-value: 2.85e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 785798227  751 FGGKGDDILDGGNGDDFIDGGKGNDLLHGGKGDDIFVhrKGDGNDIITDSDGNDKLSFSDSNLKD 815
Cdd:pfam08548  85 IGGSGNDVLIGNDADNILKGGAGNDILYGGGGADQLW--GGAGNDIFVYASAKDSLTAAPDTIRD 147
COG2931 COG2931
Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and ...
 714-796 1.80e-04

Ca2+-binding protein, RTX toxin-related [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442175 [Multi-domain]  Cd Length: 252  Bit Score: 44.13  E-value: 1.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 785798227 714 IIGTSHNDIFKGSKFNDAFNGGDGVDTIDGNDGNDRLFGGKGDDILDGGNGDDFIDGGKGNDLLHGGKGDDIFVHRKGDG 793
Cdd:COG2931  169 LDGGAGNDTLTGGAGNDTLTGGAGNDTLDGGGGDDTLGGGGGDDGLDGGDGDDGLGGGGGDDTLGGGGGGDGGGGGGGDD 248


                 ...
gi 785798227 794 NDI 796
Cdd:COG2931  249 GLG 251
HemolysinCabind pfam00353
RTX calcium-binding nonapeptide repeat (4 copies);
715-750 1.91e-04

RTX calcium-binding nonapeptide repeat (4 copies);


Pssm-ID: 459777 [Multi-domain]  Cd Length: 36  Bit Score: 39.34  E-value: 1.91e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 785798227  715 IGTSHNDIFKGSKFNDAFNGGDGVDTIDGNDGNDRL 750
Cdd:pfam00353   1 YGGDGNDTLVGGAGNDTIYGGAGNDTLDGGAGNDTL 36
Peptidase_M10_C pfam08548
Peptidase M10 serralysin C terminal; Serralysins are peptidases related to mammalian matrix ...
 711-766 7.97e-04

Peptidase M10 serralysin C terminal; Serralysins are peptidases related to mammalian matrix metallopeptidases (MMPs). The peptidase unit is found at the N terminal while this domain at the C terminal forms a corkscrew and is thought to be important for secretion of the protein through the bacterial cell wall. This domain contains the calcium ion binding domain pfam00353.


Pssm-ID: 430067 [Multi-domain]  Cd Length: 222  Bit Score: 41.97  E-value: 7.97e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 785798227  711 VEEIIGTSHNDIFKGSKFNDAFNGGDGVDTIDGNDGNDRLFGGKGDDILDGGNGDD 766
Cdd:pfam08548  81 IENAIGGSGNDVLIGNDADNILKGGAGNDILYGGGGADQLWGGAGNDIFVYASAKD 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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