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Conserved domains on  [gi|768897425|gb|AJW25490|]
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Cdc60p [Saccharomyces cerevisiae YJM693]

Protein Classification

nucleotidyl transferase family protein( domain architecture ID 117)

nucleotidyl transferase (NT) family protein contains a conserved dinucleotide-binding domain; the NT superfamily includes the class I amino-acyl tRNA synthetases, pantothenate synthetase (PanC), ATP sulfurylase, and cytidylyltransferases

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
nt_trans super family cl00015
nucleotidyl transferase superfamily; nt_trans (nucleotidyl transferase) This superfamily ...
 17-1088 0e+00

nucleotidyl transferase superfamily; nt_trans (nucleotidyl transferase) This superfamily includes the class I amino-acyl tRNA synthetases, pantothenate synthetase (PanC), ATP sulfurylase, and the cytidylyltransferases, all of which have a conserved dinucleotide-binding domain.


The actual alignment was detected with superfamily member TIGR00395:

Pssm-ID: 469580 [Multi-domain]  Cd Length: 938  Bit Score: 1453.10  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425    17 IAIEKKYQKIWAEEHQFEIDapsiddepitMDSEElhrkypKFMSSMAYPYMNGVMHAGHCFTLSKVEFSIGFERMNGKR 96
Cdd:TIGR00395    1 IAIEKKWQKRWEEAHIFEAD----------PDDRE------KFFLTMAYPYLNGVMHAGHCRTFTIPEVSARFERMKGKN 64

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425    97 ALFPLGFHCTGMPILACADKLKREAELFGKNFDNVPaeeeeikeetpaekdhedvtkfkakkskaaakkgrgkyqfeiml 176
Cdd:TIGR00395   65 VLFPLGFHVTGTPILGLAELIKRRDELTIKNYTEVH-------------------------------------------- 100

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   177 qlGIPREEIIKFADAKYWLTYFPPLCESDCTSLGARIDWRRSFVTTDanPYYDAFIRWQMNKLKAAGKIKFGERYTIYSE 256
Cdd:TIGR00395  101 --AIPREELLKFTDPEYIVEYFSREAESACKSMGYSIDWRRSFKTTD--PYYDRFIEWQMNKLKELGLIVKGEHPVRYCP 176

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   257 KDGQACMDHDRQSGEGVTPQEYIGVKIEALEFAddaakiidsssdldkskkFYFVAATLRPETMYGQTCCFVSPTIEYGI 336
Cdd:TIGR00395  177 KDGNPVEDHDLLSGEGVTIVEYILIKFELEDGA------------------FYFVAATLRPETVYGVTNCWVNPTITYVI 238

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   337 FDAGDSYFITTERAFKNMSYQKLTpkrgfYKPIVTVPGKAFIGTKIHAPqSVYPELRILPMETVIATKGTGVVTCVPSNS 416
Cdd:TIGR00395  239 AEVGGEKWITSKEAFENLSYQKLK-----YKPIEEVPGKQFIGKKVHNP-VVGPEVPILPAEFVDTTKGTGVVMSVPAHA 312

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   417 PDDYITTKDLLHKPEYYGIKPEWIDHEIVPIMHTEKYGDLTAKAIVEEKKIQSPKDKNLLAEAKKIAYKEDYYTGTMIYG 496
Cdd:TIGR00395  313 PDDYIALEDLLHDPEYLGIKPVVIDIEPVPLIHTDGYGDLPAKEIVEEKGIKSQKDKNLLEEATKILYKEEYHTGVMIYN 392

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   497 --PYKGEKVEQAKNKVKADMIAAGEAFVYNEP-ESQVMSRSGDDCIVS-LEDQWYVDYGEESWKKQAIECLEGMQLFAPE 572
Cdd:TIGR00395  393 ipPYKGMKVSEAKEKVKADLIDAGLADVMYEFsESPVICRCGTDCIVKvVEDQWFVKYSDESWKELAHECLEGMRIIPEE 472

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   573 VKNAFEGVLDWLKNWAVCRTYGLGTRLPWDEKYLVESLSDSTIYQSFYTIAHLLFKDYYGNEigplgisadQMTDEVFDY 652
Cdd:TIGR00395  473 VKNAFEGKIDWLKDWACCRRYGLGTRLPWDEKWLIESLSDSTIYMAYYTIAHYLNKDYYGNE---------QMTDEFFDY 543

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   653 IFQHQDDVKNTNIPLPALQKLRREFEYFYPLDVSISGKDLIPNHLTFFIYTHVALFPKKFWPKGIRANGHLMLNNSKMSK 732
Cdd:TIGR00395  544 IFLGKGDVKNTNIPLPAIQKLRREFEYWYPLDWRISGKDLIPNHLTFYIFHHVAIFPEKFWPRGIVVNGYVMLEGKKMSK 623

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   733 STGNFMTLEQTVEKFGADAARIAFADAGDTVEDANFDESNANAAILRLFNLKEWAEEITKESNLRTGEITDFFDIAFEHE 812
Cdd:TIGR00395  624 SKGNVLTLEQAVEKFGADVARLYIADAAETVQDADWKESEVEGTILRLERLYEFAEEITKESNLETGEETSFIDRWLESR 703

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   813 MNALIEKTYEQYALTNYKNALKYGLFDFQAARDYYREASGVMHKDLIARYIETQALLLAPIAPHFAEYIYREVlGNQTSV 892
Cdd:TIGR00395  704 MNAAIKETYEAMENFQTRKAVKYALFDLQADVDWYRRRGGVNHKDVLARYLETWIKLLAPFAPHFAEEMWEEV-GNEGFV 782

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   893 QNAKFPRASKP-VDKGVLAALDYLRNLQRSIREgegqalkkkkgkSAEIDASKPVKLTLLISEsfpEWQSQCVEIVRKLF 971
Cdd:TIGR00395  783 SLAKFPEASEPaVDKEVEAAEEYLRNLVRDIQE------------IAKIDASKPKRVYLYTSE---DWKSQCLKIVAELF 847

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   972 SEQTLDDNKKVREhiEPKEMKRAMPFISLLKQRLANEKPEDvferELQFSEIDTVKAAARNVKKAAQALKIAEFSAISFP 1051
Cdd:TIGR00395  848 GEDTGEDMKKVME--EPEERKRGKEVISLVKQIIKDEKKED----ELQISEIEVLKAAARFIKKEVGALVIIEFSADSFP 921

                         1050      1060      1070
                   ....*....|....*....|....*....|....*..
gi 768897425  1052 YGAKTgkdiftgeeveippvtkiveNAVPGNPGVVFQ 1088
Cdd:TIGR00395  922 ENKKR--------------------NAVPGKPAIYLE 938
 
Name Accession Description Interval E-value
leuS_arch TIGR00395
leucyl-tRNA synthetase, archaeal and cytosolic family; The leucyl-tRNA synthetases belong to ...
 17-1088 0e+00

leucyl-tRNA synthetase, archaeal and cytosolic family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both archaeal and cytosolic eukaryotic leucyl-tRNA synthetases; the eubacterial and mitochondrial forms differ so substantially that some other tRNA ligases score higher by this model than does any eubacterial LeuS. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273056 [Multi-domain]  Cd Length: 938  Bit Score: 1453.10  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425    17 IAIEKKYQKIWAEEHQFEIDapsiddepitMDSEElhrkypKFMSSMAYPYMNGVMHAGHCFTLSKVEFSIGFERMNGKR 96
Cdd:TIGR00395    1 IAIEKKWQKRWEEAHIFEAD----------PDDRE------KFFLTMAYPYLNGVMHAGHCRTFTIPEVSARFERMKGKN 64

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425    97 ALFPLGFHCTGMPILACADKLKREAELFGKNFDNVPaeeeeikeetpaekdhedvtkfkakkskaaakkgrgkyqfeiml 176
Cdd:TIGR00395   65 VLFPLGFHVTGTPILGLAELIKRRDELTIKNYTEVH-------------------------------------------- 100

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   177 qlGIPREEIIKFADAKYWLTYFPPLCESDCTSLGARIDWRRSFVTTDanPYYDAFIRWQMNKLKAAGKIKFGERYTIYSE 256
Cdd:TIGR00395  101 --AIPREELLKFTDPEYIVEYFSREAESACKSMGYSIDWRRSFKTTD--PYYDRFIEWQMNKLKELGLIVKGEHPVRYCP 176

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   257 KDGQACMDHDRQSGEGVTPQEYIGVKIEALEFAddaakiidsssdldkskkFYFVAATLRPETMYGQTCCFVSPTIEYGI 336
Cdd:TIGR00395  177 KDGNPVEDHDLLSGEGVTIVEYILIKFELEDGA------------------FYFVAATLRPETVYGVTNCWVNPTITYVI 238

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   337 FDAGDSYFITTERAFKNMSYQKLTpkrgfYKPIVTVPGKAFIGTKIHAPqSVYPELRILPMETVIATKGTGVVTCVPSNS 416
Cdd:TIGR00395  239 AEVGGEKWITSKEAFENLSYQKLK-----YKPIEEVPGKQFIGKKVHNP-VVGPEVPILPAEFVDTTKGTGVVMSVPAHA 312

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   417 PDDYITTKDLLHKPEYYGIKPEWIDHEIVPIMHTEKYGDLTAKAIVEEKKIQSPKDKNLLAEAKKIAYKEDYYTGTMIYG 496
Cdd:TIGR00395  313 PDDYIALEDLLHDPEYLGIKPVVIDIEPVPLIHTDGYGDLPAKEIVEEKGIKSQKDKNLLEEATKILYKEEYHTGVMIYN 392

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   497 --PYKGEKVEQAKNKVKADMIAAGEAFVYNEP-ESQVMSRSGDDCIVS-LEDQWYVDYGEESWKKQAIECLEGMQLFAPE 572
Cdd:TIGR00395  393 ipPYKGMKVSEAKEKVKADLIDAGLADVMYEFsESPVICRCGTDCIVKvVEDQWFVKYSDESWKELAHECLEGMRIIPEE 472

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   573 VKNAFEGVLDWLKNWAVCRTYGLGTRLPWDEKYLVESLSDSTIYQSFYTIAHLLFKDYYGNEigplgisadQMTDEVFDY 652
Cdd:TIGR00395  473 VKNAFEGKIDWLKDWACCRRYGLGTRLPWDEKWLIESLSDSTIYMAYYTIAHYLNKDYYGNE---------QMTDEFFDY 543

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   653 IFQHQDDVKNTNIPLPALQKLRREFEYFYPLDVSISGKDLIPNHLTFFIYTHVALFPKKFWPKGIRANGHLMLNNSKMSK 732
Cdd:TIGR00395  544 IFLGKGDVKNTNIPLPAIQKLRREFEYWYPLDWRISGKDLIPNHLTFYIFHHVAIFPEKFWPRGIVVNGYVMLEGKKMSK 623

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   733 STGNFMTLEQTVEKFGADAARIAFADAGDTVEDANFDESNANAAILRLFNLKEWAEEITKESNLRTGEITDFFDIAFEHE 812
Cdd:TIGR00395  624 SKGNVLTLEQAVEKFGADVARLYIADAAETVQDADWKESEVEGTILRLERLYEFAEEITKESNLETGEETSFIDRWLESR 703

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   813 MNALIEKTYEQYALTNYKNALKYGLFDFQAARDYYREASGVMHKDLIARYIETQALLLAPIAPHFAEYIYREVlGNQTSV 892
Cdd:TIGR00395  704 MNAAIKETYEAMENFQTRKAVKYALFDLQADVDWYRRRGGVNHKDVLARYLETWIKLLAPFAPHFAEEMWEEV-GNEGFV 782

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   893 QNAKFPRASKP-VDKGVLAALDYLRNLQRSIREgegqalkkkkgkSAEIDASKPVKLTLLISEsfpEWQSQCVEIVRKLF 971
Cdd:TIGR00395  783 SLAKFPEASEPaVDKEVEAAEEYLRNLVRDIQE------------IAKIDASKPKRVYLYTSE---DWKSQCLKIVAELF 847

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   972 SEQTLDDNKKVREhiEPKEMKRAMPFISLLKQRLANEKPEDvferELQFSEIDTVKAAARNVKKAAQALKIAEFSAISFP 1051
Cdd:TIGR00395  848 GEDTGEDMKKVME--EPEERKRGKEVISLVKQIIKDEKKED----ELQISEIEVLKAAARFIKKEVGALVIIEFSADSFP 921

                         1050      1060      1070
                   ....*....|....*....|....*....|....*..
gi 768897425  1052 YGAKTgkdiftgeeveippvtkiveNAVPGNPGVVFQ 1088
Cdd:TIGR00395  922 ENKKR--------------------NAVPGKPAIYLE 938
PLN02959 PLN02959
aminoacyl-tRNA ligase
 8-1087 0e+00

aminoacyl-tRNA ligase


Pssm-ID: 215518 [Multi-domain]  Cd Length: 1084  Bit Score: 1173.31  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425    8 ENTARRDALIAIEKKYQKIWAEEHQFEIDAPSIDDEPItmdseelhrkyPKFMSSMAYPYMNGVMHAGHCFTLSKVEFSI 87
Cdd:PLN02959    7 KSTARRDRLLEIEVAVQKWWEEEKVFEAEAGDEPPKPG-----------EKFFGNFPYPYMNGLLHLGHAFSLSKLEFAA 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   88 GFERMNGKRALFPLGFHCTGMPILACADKLKREAELFGkNFDNVPAEEEEIKEETPAEKDHEDV-----TKFKAKKSKAA 162
Cdd:PLN02959   76 AYHRLRGANVLLPFAFHCTGMPIKASADKLAREIQQYG-NPPVFPEEDEDEAAAVAAAKAEAEAaaappDKFKGKKSKAV 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  163 AKKGRGKYQFEIMLQLGIPREEIIKFADAKYWLTYFPPLCESDCTSLGARIDWRRSFVTTDANPYYDAFIRWQMNKLKAA 242
Cdd:PLN02959  155 AKSGTQKYQWEIMRSFGLPDSEIAKFQDPYHWLSYFPPLAKEDLKAFGLGCDWRRSFITTDVNPYYDAFVRWQFRKLKKK 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  243 GKIKFGERYTIYSEKDGQACMDHDRQSGEGVTPQEYIGVKIEAL-EFADDAAKIidsssdldKSKKFYFVAATLRPETMY 321
Cdd:PLN02959  235 GKIVKDKRYTIYSPLDGQPCADHDRASGEGVGPQEYVLIKMEVLpPFPGKLKAL--------EGKKVFLAAATLRPETMY 306

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  322 GQTCCFVSPTIEYGIFDAGDS-YFITTERAFKNMSYQKLTPKRGFYKPIVTVPGKAFIGTKIHAPQSVYPELRILPMETV 400
Cdd:PLN02959  307 GQTNCWVLPDGKYGAYEINDTeVFILTARAALNLAYQNFSKVPGKPTCLVELTGYDLIGLPLKSPLAFNEVIYALPMLTI 386

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  401 IATKGTGVVTCVPSNSPDDYITTKDLLHKP---EYYGIKPEWID-HEIVPIMHTEKYGDLTAKAIVEEKKIQSPKDKNLL 476
Cdd:PLN02959  387 LTDKGTGVVTSVPSDSPDDYMALSDLKAKPalrAKYGVKDEWVLpFEVVPIINIPEFGDKSAEKVCEDLKIKSQNDKEKL 466

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  477 AEAKKIAYKEDYYTGTMIYGPYKGEKVEQAKNKVKADMIAAGEAFVYNEPESQVMSRSGDDCIVSLEDQWYVDYGEESWK 556
Cdd:PLN02959  467 AEAKRLTYLKGFTDGTMLVGEYAGRKVQEAKPLIKKKLIEAGQAILYSEPEKKVMSRSGDECVVALTDQWYLTYGEEEWK 546

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  557 KQAIECLEGMQLFAPEVKNAFEGVLDWLKNWAVCRTYGLGTRLPWDEKYLVESLSDSTIYQSFYTIAHLLFK-DYYGNEI 635
Cdd:PLN02959  547 KKAEKCLSKMNLYSDETRHGFEHTLGWLNQWACSRSFGLGTRIPWDEQFLIESLSDSTIYMAYYTVAHLLQGgDMYGKDK 626

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  636 GPlgISADQMTDEVFDYIFQHQDDVKNTNIPLPALQKLRREFEYFYPLDVSISGKDLIPNHLTFFIYTHVALFPKKFWPK 715
Cdd:PLN02959  627 SS--IKPEQMTDEVWDFVFCGGPLPKSSDIPAELLEKMKQEFEYWYPFDLRVSGKDLIQNHLTFAIYNHTAIWAEEHWPR 704

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  716 GIRANGHLMLNNSKMSKSTGNFMTLEQTVEKFGADAARIAFADAGDTVEDANFDESNANAAILRLFNLKEWAEEITK-ES 794
Cdd:PLN02959  705 GFRCNGHLMLNSEKMSKSTGNFLTLRQAIEEFSADATRFALADAGDGVDDANFVFETANAAILRLTKEIAWMEEVLAaES 784

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  795 NLRTGEITDFFDIAFEHEMNALIEKTYEQYALTNYKNALKYGLFDFQAARDYYREASGV--MHKDLIARYIETQALLLAP 872
Cdd:PLN02959  785 SLRTGPPSTYADRVFENEINIAIAETEKNYEAMMFREALKSGFYDLQAARDEYRLSCGSggMNRDLVWRFMDVQTRLITP 864

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  873 IAPHFAEYIYREVLGNQTSVQNAKFPRASKPvDKGVLAALDYLRNLQRSIREGEGQALK--KKKGKSAEIDASKPVKLTL 950
Cdd:PLN02959  865 ICPHYAEHVWREILKKEGFAVTAGWPVAGEP-DLTLKRANKYLQDSIVSFRKLLQKQLAgsKKAKKGGAPVTLPEKKLAG 943

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  951 LI--SESFPEWQSQCVEIVRKLFSEQT------------LDDNKKVREHIEPKEMKRAMPFISlLKQRLANEKPEDVFER 1016
Cdd:PLN02959  944 LIyvAEKYDGWKEECLRILQSKFDSQSrtfapdaeileaLKESSVGQEANFKQVQKLCMPFVK-FKKDEAIAVGPQALDL 1022

                        1050      1060      1070      1080      1090      1100      1110
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 768897425 1017 ELQFSEIDTVKaaaRNVKKAAQALKIAEFSAISfpyGAKTGKDIFTGEEVEIPPVTkiveNAVPGNPGVVF 1087
Cdd:PLN02959 1023 KLPFDEIEVLQ---ENLELIKRQLGLEEVEILS---ASDPDAVAKAGAHASLLKQN----PPSPGNPVAIF 1083
LeuRS_core cd00812
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ...
 542-770 2.19e-75

catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.


Pssm-ID: 173906 [Multi-domain]  Cd Length: 314  Bit Score: 251.40  E-value: 2.19e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  542 LEDQWYVDYGEESWKKQAIECLEGMQLFAPEVKNAFEGVLDwlknwaVCRTYGLGTRLPWdeKYLVESLSDSTIYQSFYT 621
Cdd:cd00812   128 LLDQWFLKYSETEWKEKLLKDLEKLDGWPEEVRAMQENWIG------CSRQRYWGTPIPW--TDTMESLSDSTWYYARYT 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  622 IAHLLFKDYYGneigplgisadqmtdevfdyifqhqddvkntniplpALQKLRREFEYFYPLDVSISGKDLIPNHLTFFI 701
Cdd:cd00812   200 DAHNLEQPYEG------------------------------------DLEFDREEFEYWYPVDIYIGGKEHAPNHLLYSR 243

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 768897425  702 YTHVALFPKK----FWPKGIRANGHLMLNNSKMSKSTGNFMTLEQTVEKFGADAARIAFADAGDtvEDANFDE 770
Cdd:cd00812   244 FNHKALFDEGlvtdEPPKGLIVQGMVLLEGEKMSKSKGNVVTPDEAIKKYGADAARLYILFAAP--PDADFDW 314
tRNA-synt_1 pfam00133
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ...
 22-769 1.13e-27

tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.


Pssm-ID: 459685 [Multi-domain]  Cd Length: 602  Bit Score: 119.82  E-value: 1.13e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425    22 KYQKIWAEEHQFEIdapsiddepitmdSEELHRKYPKFMSSMAYPYMNGVMHAGHCFTLSKVEFSIGFERMNGKRALFPL 101
Cdd:pfam00133    1 QIYEFWDEQGYFKP-------------ELEKRKGKPSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVP 67

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   102 GFHCTGMPIlacadKLKREAELfgknfdnvpaeeeeikeetpAEKDHEDVtkfkakkskaaAKKGRGKYqfeimlqlgip 181
Cdd:pfam00133   68 GWDHHGLPT-----EQVVEKKL--------------------GIKEKKTR-----------HKYGREEF----------- 100

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   182 REEIikfadaKYWLTYFPPLCESDCTSLGARIDWRRSFVTTDanPYYDAFIRWQMNKLKAAGKIKFGERYTIYSEKDGQA 261
Cdd:pfam00133  101 REKC------REWKMEYADEIRKQFRRLGRSIDWDREYFTMD--PELEAAVWEVFVRLHDKGLIYRGKKLVNWSPALNTA 172

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   262 CMDhdrqsgegvtpqeyigvkIEAlEFADDAAKIIDSSSDLDKSKKFYFVAATLRPETMYGQTCCFVSPTIEYGIfdaGD 341
Cdd:pfam00133  173 LSN------------------LEV-EYKDVKGPSIHVAFPLADDEGASLVIWTTTPWTLPGNTAVAVNPEFDYVI---TG 230

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   342 SYFITTERAFKNMsYQKLTPkrgfYKPIVTVPGKAFIGTKIHAPqSVYPELRILPMETVIATKGTGVVTCVPSNSPDDYI 421
Cdd:pfam00133  231 EGYILAEALLKSL-YKKGTD----KKILEDFRGKELEGKEAIHP-FVNREIPIITDDYVDMEFGTGAVHIAPAHGENDYE 304

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   422 TTKdllhkpeyygikpewiDHEIVPIMHTEKYGDLTAKAiveekkiqspkdknllaeakkiaykedyytgtmiyGPYKGE 501
Cdd:pfam00133  305 VGQ----------------RHNLEVINPVDDDGTFTEEA-----------------------------------PDFQGV 333

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   502 KVEQAKNKVKADMIAAG-----EAFVYNEPESqvmSRSGDDCIVSLEDQWYVDYGEesWKKQAIECLEGMQlFAPEVKNA 576
Cdd:pfam00133  334 YRFDARKKIVELLTEKGlllkiEPFTHSYPFC---WRSGTPIIPRATPQWFVRMDE--LADQALEAVEKVQ-FVPKSGEK 407

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   577 FegVLDWLKN---WAVCRTYGLGTRLP-W-----DEKYLVESLSD--STIYQSFYTIA--HLLFKDYYGNEIGPLgisad 643
Cdd:pfam00133  408 R--YFNWLANiqdWCISRQRWWGHPIPaWvskdtEEVVCRGELFElvAGRFEEEGSIKwlHREAKDKLGYGKGTL----- 480

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   644 QMTDEVFDYIFqhqDDVKNTNIPLPALQKLRREFEYFYPLDVSISGKDLIPNHLTFFIYTHVALF---PKKFwpkgIRAN 720
Cdd:pfam00133  481 EQDEDVLDTWF---SSGSWPFSTLGWPFVNTEEFKKFFPADMLLEGSDQTRGWFYRMIMLSTALTgsvPFKN----VLVH 553

                          730       740       750       760       770
                   ....*....|....*....|....*....|....*....|....*....|
gi 768897425   721 GHLM-LNNSKMSKSTGNFMTLEQTVEKFGADAARIAFADAgDTVEDANFD 769
Cdd:pfam00133  554 GLVRdEQGRKMSKSLGNVIDPLDVIDKYGADALRLWLANS-DYGRDINLS 602
LeuS COG0495
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ...
 720-900 1.06e-12

Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 440261 [Multi-domain]  Cd Length: 826  Bit Score: 72.39  E-value: 1.06e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  720 NGHLMLNNSKMSKSTGNFMTLEQTVEKFGADAAR--IAFadAGDTVEDANFDESNANAA---ILRLFNLkewAEEITKES 794
Cdd:COG0495   580 DGVVIGGIEKMSKSKGNVVDPDEIIEKYGADTLRlfEMF--AGPPERDLEWSDSGVEGAyrfLNRVWRL---VVDEAEAL 654

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  795 NLRTGEITDfFDIAFEHEMNALIEKT---YEQY-------ALTNYKNALKYGLFDFQAARDYYREAsgvmhkdliaryIE 864
Cdd:COG0495   655 KLDVADLSE-ADKELRRALHKTIKKVtedIERLrfntaiaALMELVNALYKAKDSGEADRAVLREA------------LE 721

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 768897425  865 TQALLLAPIAPHFAEYIYrEVLGNQTSVQNAKFPRA 900
Cdd:COG0495   722 TLVLLLAPFAPHIAEELW-ERLGHEGSVADAPWPEA 756
 
Name Accession Description Interval E-value
leuS_arch TIGR00395
leucyl-tRNA synthetase, archaeal and cytosolic family; The leucyl-tRNA synthetases belong to ...
 17-1088 0e+00

leucyl-tRNA synthetase, archaeal and cytosolic family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both archaeal and cytosolic eukaryotic leucyl-tRNA synthetases; the eubacterial and mitochondrial forms differ so substantially that some other tRNA ligases score higher by this model than does any eubacterial LeuS. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273056 [Multi-domain]  Cd Length: 938  Bit Score: 1453.10  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425    17 IAIEKKYQKIWAEEHQFEIDapsiddepitMDSEElhrkypKFMSSMAYPYMNGVMHAGHCFTLSKVEFSIGFERMNGKR 96
Cdd:TIGR00395    1 IAIEKKWQKRWEEAHIFEAD----------PDDRE------KFFLTMAYPYLNGVMHAGHCRTFTIPEVSARFERMKGKN 64

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425    97 ALFPLGFHCTGMPILACADKLKREAELFGKNFDNVPaeeeeikeetpaekdhedvtkfkakkskaaakkgrgkyqfeiml 176
Cdd:TIGR00395   65 VLFPLGFHVTGTPILGLAELIKRRDELTIKNYTEVH-------------------------------------------- 100

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   177 qlGIPREEIIKFADAKYWLTYFPPLCESDCTSLGARIDWRRSFVTTDanPYYDAFIRWQMNKLKAAGKIKFGERYTIYSE 256
Cdd:TIGR00395  101 --AIPREELLKFTDPEYIVEYFSREAESACKSMGYSIDWRRSFKTTD--PYYDRFIEWQMNKLKELGLIVKGEHPVRYCP 176

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   257 KDGQACMDHDRQSGEGVTPQEYIGVKIEALEFAddaakiidsssdldkskkFYFVAATLRPETMYGQTCCFVSPTIEYGI 336
Cdd:TIGR00395  177 KDGNPVEDHDLLSGEGVTIVEYILIKFELEDGA------------------FYFVAATLRPETVYGVTNCWVNPTITYVI 238

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   337 FDAGDSYFITTERAFKNMSYQKLTpkrgfYKPIVTVPGKAFIGTKIHAPqSVYPELRILPMETVIATKGTGVVTCVPSNS 416
Cdd:TIGR00395  239 AEVGGEKWITSKEAFENLSYQKLK-----YKPIEEVPGKQFIGKKVHNP-VVGPEVPILPAEFVDTTKGTGVVMSVPAHA 312

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   417 PDDYITTKDLLHKPEYYGIKPEWIDHEIVPIMHTEKYGDLTAKAIVEEKKIQSPKDKNLLAEAKKIAYKEDYYTGTMIYG 496
Cdd:TIGR00395  313 PDDYIALEDLLHDPEYLGIKPVVIDIEPVPLIHTDGYGDLPAKEIVEEKGIKSQKDKNLLEEATKILYKEEYHTGVMIYN 392

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   497 --PYKGEKVEQAKNKVKADMIAAGEAFVYNEP-ESQVMSRSGDDCIVS-LEDQWYVDYGEESWKKQAIECLEGMQLFAPE 572
Cdd:TIGR00395  393 ipPYKGMKVSEAKEKVKADLIDAGLADVMYEFsESPVICRCGTDCIVKvVEDQWFVKYSDESWKELAHECLEGMRIIPEE 472

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   573 VKNAFEGVLDWLKNWAVCRTYGLGTRLPWDEKYLVESLSDSTIYQSFYTIAHLLFKDYYGNEigplgisadQMTDEVFDY 652
Cdd:TIGR00395  473 VKNAFEGKIDWLKDWACCRRYGLGTRLPWDEKWLIESLSDSTIYMAYYTIAHYLNKDYYGNE---------QMTDEFFDY 543

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   653 IFQHQDDVKNTNIPLPALQKLRREFEYFYPLDVSISGKDLIPNHLTFFIYTHVALFPKKFWPKGIRANGHLMLNNSKMSK 732
Cdd:TIGR00395  544 IFLGKGDVKNTNIPLPAIQKLRREFEYWYPLDWRISGKDLIPNHLTFYIFHHVAIFPEKFWPRGIVVNGYVMLEGKKMSK 623

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   733 STGNFMTLEQTVEKFGADAARIAFADAGDTVEDANFDESNANAAILRLFNLKEWAEEITKESNLRTGEITDFFDIAFEHE 812
Cdd:TIGR00395  624 SKGNVLTLEQAVEKFGADVARLYIADAAETVQDADWKESEVEGTILRLERLYEFAEEITKESNLETGEETSFIDRWLESR 703

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   813 MNALIEKTYEQYALTNYKNALKYGLFDFQAARDYYREASGVMHKDLIARYIETQALLLAPIAPHFAEYIYREVlGNQTSV 892
Cdd:TIGR00395  704 MNAAIKETYEAMENFQTRKAVKYALFDLQADVDWYRRRGGVNHKDVLARYLETWIKLLAPFAPHFAEEMWEEV-GNEGFV 782

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   893 QNAKFPRASKP-VDKGVLAALDYLRNLQRSIREgegqalkkkkgkSAEIDASKPVKLTLLISEsfpEWQSQCVEIVRKLF 971
Cdd:TIGR00395  783 SLAKFPEASEPaVDKEVEAAEEYLRNLVRDIQE------------IAKIDASKPKRVYLYTSE---DWKSQCLKIVAELF 847

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   972 SEQTLDDNKKVREhiEPKEMKRAMPFISLLKQRLANEKPEDvferELQFSEIDTVKAAARNVKKAAQALKIAEFSAISFP 1051
Cdd:TIGR00395  848 GEDTGEDMKKVME--EPEERKRGKEVISLVKQIIKDEKKED----ELQISEIEVLKAAARFIKKEVGALVIIEFSADSFP 921

                         1050      1060      1070
                   ....*....|....*....|....*....|....*..
gi 768897425  1052 YGAKTgkdiftgeeveippvtkiveNAVPGNPGVVFQ 1088
Cdd:TIGR00395  922 ENKKR--------------------NAVPGKPAIYLE 938
PLN02959 PLN02959
aminoacyl-tRNA ligase
 8-1087 0e+00

aminoacyl-tRNA ligase


Pssm-ID: 215518 [Multi-domain]  Cd Length: 1084  Bit Score: 1173.31  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425    8 ENTARRDALIAIEKKYQKIWAEEHQFEIDAPSIDDEPItmdseelhrkyPKFMSSMAYPYMNGVMHAGHCFTLSKVEFSI 87
Cdd:PLN02959    7 KSTARRDRLLEIEVAVQKWWEEEKVFEAEAGDEPPKPG-----------EKFFGNFPYPYMNGLLHLGHAFSLSKLEFAA 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   88 GFERMNGKRALFPLGFHCTGMPILACADKLKREAELFGkNFDNVPAEEEEIKEETPAEKDHEDV-----TKFKAKKSKAA 162
Cdd:PLN02959   76 AYHRLRGANVLLPFAFHCTGMPIKASADKLAREIQQYG-NPPVFPEEDEDEAAAVAAAKAEAEAaaappDKFKGKKSKAV 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  163 AKKGRGKYQFEIMLQLGIPREEIIKFADAKYWLTYFPPLCESDCTSLGARIDWRRSFVTTDANPYYDAFIRWQMNKLKAA 242
Cdd:PLN02959  155 AKSGTQKYQWEIMRSFGLPDSEIAKFQDPYHWLSYFPPLAKEDLKAFGLGCDWRRSFITTDVNPYYDAFVRWQFRKLKKK 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  243 GKIKFGERYTIYSEKDGQACMDHDRQSGEGVTPQEYIGVKIEAL-EFADDAAKIidsssdldKSKKFYFVAATLRPETMY 321
Cdd:PLN02959  235 GKIVKDKRYTIYSPLDGQPCADHDRASGEGVGPQEYVLIKMEVLpPFPGKLKAL--------EGKKVFLAAATLRPETMY 306

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  322 GQTCCFVSPTIEYGIFDAGDS-YFITTERAFKNMSYQKLTPKRGFYKPIVTVPGKAFIGTKIHAPQSVYPELRILPMETV 400
Cdd:PLN02959  307 GQTNCWVLPDGKYGAYEINDTeVFILTARAALNLAYQNFSKVPGKPTCLVELTGYDLIGLPLKSPLAFNEVIYALPMLTI 386

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  401 IATKGTGVVTCVPSNSPDDYITTKDLLHKP---EYYGIKPEWID-HEIVPIMHTEKYGDLTAKAIVEEKKIQSPKDKNLL 476
Cdd:PLN02959  387 LTDKGTGVVTSVPSDSPDDYMALSDLKAKPalrAKYGVKDEWVLpFEVVPIINIPEFGDKSAEKVCEDLKIKSQNDKEKL 466

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  477 AEAKKIAYKEDYYTGTMIYGPYKGEKVEQAKNKVKADMIAAGEAFVYNEPESQVMSRSGDDCIVSLEDQWYVDYGEESWK 556
Cdd:PLN02959  467 AEAKRLTYLKGFTDGTMLVGEYAGRKVQEAKPLIKKKLIEAGQAILYSEPEKKVMSRSGDECVVALTDQWYLTYGEEEWK 546

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  557 KQAIECLEGMQLFAPEVKNAFEGVLDWLKNWAVCRTYGLGTRLPWDEKYLVESLSDSTIYQSFYTIAHLLFK-DYYGNEI 635
Cdd:PLN02959  547 KKAEKCLSKMNLYSDETRHGFEHTLGWLNQWACSRSFGLGTRIPWDEQFLIESLSDSTIYMAYYTVAHLLQGgDMYGKDK 626

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  636 GPlgISADQMTDEVFDYIFQHQDDVKNTNIPLPALQKLRREFEYFYPLDVSISGKDLIPNHLTFFIYTHVALFPKKFWPK 715
Cdd:PLN02959  627 SS--IKPEQMTDEVWDFVFCGGPLPKSSDIPAELLEKMKQEFEYWYPFDLRVSGKDLIQNHLTFAIYNHTAIWAEEHWPR 704

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  716 GIRANGHLMLNNSKMSKSTGNFMTLEQTVEKFGADAARIAFADAGDTVEDANFDESNANAAILRLFNLKEWAEEITK-ES 794
Cdd:PLN02959  705 GFRCNGHLMLNSEKMSKSTGNFLTLRQAIEEFSADATRFALADAGDGVDDANFVFETANAAILRLTKEIAWMEEVLAaES 784

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  795 NLRTGEITDFFDIAFEHEMNALIEKTYEQYALTNYKNALKYGLFDFQAARDYYREASGV--MHKDLIARYIETQALLLAP 872
Cdd:PLN02959  785 SLRTGPPSTYADRVFENEINIAIAETEKNYEAMMFREALKSGFYDLQAARDEYRLSCGSggMNRDLVWRFMDVQTRLITP 864

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  873 IAPHFAEYIYREVLGNQTSVQNAKFPRASKPvDKGVLAALDYLRNLQRSIREGEGQALK--KKKGKSAEIDASKPVKLTL 950
Cdd:PLN02959  865 ICPHYAEHVWREILKKEGFAVTAGWPVAGEP-DLTLKRANKYLQDSIVSFRKLLQKQLAgsKKAKKGGAPVTLPEKKLAG 943

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  951 LI--SESFPEWQSQCVEIVRKLFSEQT------------LDDNKKVREHIEPKEMKRAMPFISlLKQRLANEKPEDVFER 1016
Cdd:PLN02959  944 LIyvAEKYDGWKEECLRILQSKFDSQSrtfapdaeileaLKESSVGQEANFKQVQKLCMPFVK-FKKDEAIAVGPQALDL 1022

                        1050      1060      1070      1080      1090      1100      1110
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 768897425 1017 ELQFSEIDTVKaaaRNVKKAAQALKIAEFSAISfpyGAKTGKDIFTGEEVEIPPVTkiveNAVPGNPGVVF 1087
Cdd:PLN02959 1023 KLPFDEIEVLQ---ENLELIKRQLGLEEVEILS---ASDPDAVAKAGAHASLLKQN----PPSPGNPVAIF 1083
leuS PRK12300
leucyl-tRNA synthetase; Reviewed
 72-1086 0e+00

leucyl-tRNA synthetase; Reviewed


Pssm-ID: 237049 [Multi-domain]  Cd Length: 897  Bit Score: 653.86  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   72 MHAGHCFTlskveFSIG-----FERMNGKRALFPLGFHCTGMPILACADKLKREAELFGKNFDNVpaeeeeikeetpaek 146
Cdd:PRK12300    1 LHVGHGRT-----YTIGdviarYKRMRGYNVLFPMAFHVTGTPILGIAERIARGDPETIELYKSL--------------- 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  147 dhedvtkfkakkskaaakkgrgkyqfeimlqLGIPREEIIKFADAKYWLTYFPPLCESDCTSLGARIDWRRSFVTTDanP 226
Cdd:PRK12300   61 -------------------------------YGIPEEELEKFKDPEYIVEYFSEEAKEDMKRIGYSIDWRREFTTTD--P 107

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  227 YYDAFIRWQMNKLKAAGKIKFGERYTIYSEKDGQACMDHDRQSGEGVTPQEYIGVKIEalefaddaakiidsssdldKSK 306
Cdd:PRK12300  108 EYSKFIEWQFRKLKEKGLIVKGSHPVRYCPNDNNPVGDHDLLDGEEPEIVEYTLIKFE-------------------ESE 168

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  307 KFYFVAATLRPETMYGQTCCFVSPTIEYGIFDAGDSYFITTERAFKNMSYQKLTpkrgfYKPIVTVPGKAFIGTKIhapq 386
Cdd:PRK12300  169 DLILPAATLRPETIFGVTNLWVNPDATYVKAEVDGEKWIVSKEAAEKLSFQDRD-----VEIIEEIKGSELIGKKV---- 239

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  387 sVYP----ELRILPMETVIATKGTGVVTCVPSNSPDDYITTKDLLHKPEYYGIKpewidhEIVPIMHTEKYGDLTAKAIV 462
Cdd:PRK12300  240 -KNPvtgkEVPILPADFVDPDNGTGVVMSVPAHAPYDYVALRDLKKNKELLDVI------EPIPLIEVEGYGEFPAKEVV 312

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  463 EEKKIQSPKDKNLlAEAKKIAYKEDYYTGTMI--YGPYKGEKVEQAKNKVKADMIAAGEAFVYNE-PESQVMSRSGDDCI 539
Cdd:PRK12300  313 EKLGIKSQEDPEL-EEATKEVYRAEFHKGVLKenTGEYAGKPVREAREKITKDLIEKGIADIMYEfSNRPVYCRCGTECV 391

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  540 VS-LEDQWYVDYGEESWKKQAIECLEGMQLFAPEVKNAFEGVLDWLKNWAVCRTYGLGTRLPWDEKYLVESLSDSTIYQS 618
Cdd:PRK12300  392 VKvVKDQWFIDYSDPEWKELAHKALDNMEIIPEEYRKEFENTIDWLKDRACARRRGLGTRLPWDEEWIIESLSDSTIYMA 471

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  619 FYTIAHLLfKDYygneigplGISADQMTDEVFDYIFQHQDDV----KNTNIPLPALQKLRREFEYFYPLDVSISGKDLIP 694
Cdd:PRK12300  472 YYTIAHKI-REY--------GIKPEQLTPEFFDYVFLGKGDPeevsKKTGIPKEILEEMREEFLYWYPVDWRHSGKDLIP 542

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  695 NHLTFFIYTHVALFPKKFWPKGIRANGHLMLNNSKMSKSTGNFMTLEQTVEKFGADAARIAFADAGDTVEDANFDESNAN 774
Cdd:PRK12300  543 NHLTFFIFNHVAIFPEEKWPRGIVVNGFVLLEGKKMSKSKGNVIPLRKAIEEYGADVVRLYLTSSAELLQDADWREKEVE 622

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  775 AAILRlfnLKEWAEEITKESNLRTGEITDFFDIAFEHEMNALIEKTYEQYALTNYKNALKYGLFDFQAARDYYREASGVM 854
Cdd:PRK12300  623 SVRRQ---LERFYELAKELIEIGGEEELRFIDKWLLSRLNRIIKETTEAMESFQTRDAVQEAFYELLNDLRWYLRRVGEA 699

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  855 HKDLIARYIETQALLLAPIAPHFAEYIYrEVLGNQTSVQNAKFPRASK-PVDKGVLAALDYLRNLQRSIREgegqaLKKK 933
Cdd:PRK12300  700 NNKVLREVLEIWIRLLAPFTPHLAEELW-HKLGGEGFVSLEKWPEPDEsKIDEEAELAEEYVKRLIEDIRE-----ILKV 773

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  934 KGKsaeidasKPVKLTLLISesfPEWQSQCVEIVRKLfseqtLDDNKKVREHIEPKEMKRAMPFISLLKQRLANEKPEDV 1013
Cdd:PRK12300  774 AKI-------KPKKVYIYVA---PDWKYEVLEIAAEN-----GDVKEAIKELMKDEELRKHGKEVAKLAQKIVKEVLKLD 838

                         970       980       990      1000      1010      1020      1030
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 768897425 1014 FE-RELQFSEIDTVKAaarnVKKAAQALKIAefsaisfpygaktgkdifTGEEVEI-----PPVTKIVENAVPGNPGVV 1086
Cdd:PRK12300  839 KEvRKLILKNIDEEEV----LEEAKDFLEKE------------------LGVEVEIygaddPGKKKKKKKALPLKPAIY 895
LeuRS_core cd00812
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ...
 542-770 2.19e-75

catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.


Pssm-ID: 173906 [Multi-domain]  Cd Length: 314  Bit Score: 251.40  E-value: 2.19e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  542 LEDQWYVDYGEESWKKQAIECLEGMQLFAPEVKNAFEGVLDwlknwaVCRTYGLGTRLPWdeKYLVESLSDSTIYQSFYT 621
Cdd:cd00812   128 LLDQWFLKYSETEWKEKLLKDLEKLDGWPEEVRAMQENWIG------CSRQRYWGTPIPW--TDTMESLSDSTWYYARYT 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  622 IAHLLFKDYYGneigplgisadqmtdevfdyifqhqddvkntniplpALQKLRREFEYFYPLDVSISGKDLIPNHLTFFI 701
Cdd:cd00812   200 DAHNLEQPYEG------------------------------------DLEFDREEFEYWYPVDIYIGGKEHAPNHLLYSR 243

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 768897425  702 YTHVALFPKK----FWPKGIRANGHLMLNNSKMSKSTGNFMTLEQTVEKFGADAARIAFADAGDtvEDANFDE 770
Cdd:cd00812   244 FNHKALFDEGlvtdEPPKGLIVQGMVLLEGEKMSKSKGNVVTPDEAIKKYGADAARLYILFAAP--PDADFDW 314
Anticodon_Ia_Leu_AEc cd07959
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ...
 768-885 6.42e-39

Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.


Pssm-ID: 153413 [Multi-domain]  Cd Length: 117  Bit Score: 140.42  E-value: 6.42e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  768 FDESNANAAILRLFNLKEWAEEITKESnlRTGEITDFFDIAFEHEMNALIEKTYEQYALTNYKNALKYGLFDFQAARDYY 847
Cdd:cd07959     1 FREEEANSAILRLERFYELAEELIETE--GELEELTFIDRWLLSRLNRLIKETTEAYENMQFREALKEGLYELQNDLDWY 78

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 768897425  848 REASGV-MHKDLIARYIETQALLLAPIAPHFAEYIYREV 885
Cdd:cd07959    79 RERGGAgMNKDLLRRFIEVWTRLLAPFAPHLAEEIWHEL 117
LeuRS_core cd00812
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ...
 58-217 1.92e-32

catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.


Pssm-ID: 173906 [Multi-domain]  Cd Length: 314  Bit Score: 128.90  E-value: 1.92e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   58 KFMSSMAYPYMNGVMHAGHCFTLSKVEFSIGFERMNGKRALFPLGFHCTGMPILACADKLKReaelfgknfdnvpaeeee 137
Cdd:cd00812     1 KFYILVMFPYPSGALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLPAENAAIKIGR------------------ 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  138 ikeetpaekDHEDVTKFKAKKSKAAAKKGRGKYQFEIMLQLGIPreeiiKFADAKYWLTYFPPLCeSDCTSLGARIDWRR 217
Cdd:cd00812    63 ---------DPEDWTEYNIKKMKEQLKRMGFSYDWRREFTTCDP-----EYYKFTQWLFLKLYEK-GLAYKKEAPVNWCK 127
valS TIGR00422
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ...
 17-950 1.47e-31

valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273070 [Multi-domain]  Cd Length: 861  Bit Score: 133.26  E-value: 1.47e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425    17 IAIEKKYQKIWAEEHQFEIDAPSiDDEPITMDseelhrkypkfmssMAYPYMNGVMHAGHCFTLSKVEFSIGFERMNGKR 96
Cdd:TIGR00422    8 HEVEKKWYKKWEKSGFFKPDGNS-NKPPFCID--------------IPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYN 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425    97 ALFPLGFHCTGMPIlacadKLKREAELFGKNfdnvpaeeeeikeetpaeKDHEDVtkfkakkskaaakkGRGKYqfeiml 176
Cdd:TIGR00422   73 VLWLPGTDHAGIAT-----QVKVEKKLGAEG------------------KTKHDL--------------GREEF------ 109

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   177 qlgipREEIIKFADakywltyfpplcESDCT------SLGARIDWRRSFVTTDANPYY---DAFIRWQMNklkaaGKIKF 247
Cdd:TIGR00422  110 -----REKIWEWKE------------ESGGTiknqikRLGASLDWSRERFTMDEGLSKavkEAFVRLYEK-----GLIYR 167

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   248 GERYTIYSEKDGQACMDHDRQSGEGVTPQEYIGVKIEalefaddaakiiDSSSDldkskkfYFVAATLRPETMYGQTCCF 327
Cdd:TIGR00422  168 GEYLVNWDPKLNTAISDIEVEYKEVKGKLYYIRYPLA------------NGSKD-------YLVVATTRPETMFGDTAVA 228

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   328 VSPTieygifdagdsyfitTERaFKNMSYQKltpkrgfykpiVTVPgkaFIGTKIhapqsvypelRILPMETVIATKGTG 407
Cdd:TIGR00422  229 VHPE---------------DER-YKHLIGKK-----------VILP---LTGRKI----------PIIADEYVDMEFGTG 268

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   408 VVTCVPSNSPDDYITTKDllHKPEYYGIkpewIDHEivpimhtekyGDLTAKAiveekkiqspkdknllaeakkiayked 487
Cdd:TIGR00422  269 AVKVTPAHDFNDYEWGKR--HNLEFINI----LDED----------GLLNENA--------------------------- 305

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   488 yytgtmiyGPYKGEKVEQAKNKVKADMIAAGEAFVYNEPESQV--MSRSGDDCIVSLEDQWYVDYgeESWKKQAIECLEG 565
Cdd:TIGR00422  306 --------GKYQGLTRFEARKKIVEDLKEEGLLVKIEPHTHNVgtCWRSGTVVEPLLSKQWFVKV--EKLADKALEAAEE 375

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   566 MQL-FAPevKNAFEGVLDWLKN---WAVCRTYGLGTRLP-WdekYLVEslsdstiyqsfytiahllFKDYYgneIGPLGI 640
Cdd:TIGR00422  376 GEIkFVP--KRMEKRYLNWLRNikdWCISRQLIWGHRIPvW---YCKE------------------CGEVY---VAKEEP 429

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   641 SADQMTDEVFDYIFQHQDDVKNTNI-----PLPAL--QKLRREFEYFYPLDVSISGKDLIPNHLTFFIYTHVALFPKKFW 713
Cdd:TIGR00422  430 LPDDKTNTGPSVELEQDTDVLDTWFssslwPFSTLgwPDETKDLKKFYPTDLLVTGYDIIFFWVARMIFRSLALTGQVPF 509

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   714 pKGIRANGhlML---NNSKMSKSTGNFMTLEQTVEKFGADAARIAFADAGDTVEDANFD----ESNA-------NAAILR 779
Cdd:TIGR00422  510 -KEVYIHG--LVrdeQGRKMSKSLGNVIDPLDVIEKYGADALRFTLASLVTPGDDINFDwkrvESARnflnklwNASRFV 586

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   780 LFNLKEWAEEITKESNLRtgeitdFFDIAFEHEMNALIEKTYEqyALTNYKNAL------KYGLFDFQaarDYYREASGV 853
Cdd:TIGR00422  587 LMNLSDDLELSGGEEKLS------LADRWILSKLNRTIKEVRK--ALDKYRFAEaakalyEFIWNDFC---DWYIELVKY 655

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   854 -----------MHKDLIARYIETQALLLAPIAPHFAEYIYREVLGNQTSVQNAKFPRA-SKPVDKGVLAALDYLRNLQRS 921
Cdd:TIGR00422  656 rlyngneaekkAARDTLYYVLDKALRLLHPFMPFITEEIWQHFKEGADSIMLQSYPVVdAEFVDEEAEKAFELLKEIIVS 735

                          970       980
                   ....*....|....*....|....*....
gi 768897425   922 IREgegqaLKKKKGksaeIDASKPVKLTL 950
Cdd:TIGR00422  736 IRN-----LKAESN----IPPNAPLKVLL 755
tRNA-synt_1 pfam00133
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ...
 22-769 1.13e-27

tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.


Pssm-ID: 459685 [Multi-domain]  Cd Length: 602  Bit Score: 119.82  E-value: 1.13e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425    22 KYQKIWAEEHQFEIdapsiddepitmdSEELHRKYPKFMSSMAYPYMNGVMHAGHCFTLSKVEFSIGFERMNGKRALFPL 101
Cdd:pfam00133    1 QIYEFWDEQGYFKP-------------ELEKRKGKPSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVP 67

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   102 GFHCTGMPIlacadKLKREAELfgknfdnvpaeeeeikeetpAEKDHEDVtkfkakkskaaAKKGRGKYqfeimlqlgip 181
Cdd:pfam00133   68 GWDHHGLPT-----EQVVEKKL--------------------GIKEKKTR-----------HKYGREEF----------- 100

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   182 REEIikfadaKYWLTYFPPLCESDCTSLGARIDWRRSFVTTDanPYYDAFIRWQMNKLKAAGKIKFGERYTIYSEKDGQA 261
Cdd:pfam00133  101 REKC------REWKMEYADEIRKQFRRLGRSIDWDREYFTMD--PELEAAVWEVFVRLHDKGLIYRGKKLVNWSPALNTA 172

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   262 CMDhdrqsgegvtpqeyigvkIEAlEFADDAAKIIDSSSDLDKSKKFYFVAATLRPETMYGQTCCFVSPTIEYGIfdaGD 341
Cdd:pfam00133  173 LSN------------------LEV-EYKDVKGPSIHVAFPLADDEGASLVIWTTTPWTLPGNTAVAVNPEFDYVI---TG 230

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   342 SYFITTERAFKNMsYQKLTPkrgfYKPIVTVPGKAFIGTKIHAPqSVYPELRILPMETVIATKGTGVVTCVPSNSPDDYI 421
Cdd:pfam00133  231 EGYILAEALLKSL-YKKGTD----KKILEDFRGKELEGKEAIHP-FVNREIPIITDDYVDMEFGTGAVHIAPAHGENDYE 304

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   422 TTKdllhkpeyygikpewiDHEIVPIMHTEKYGDLTAKAiveekkiqspkdknllaeakkiaykedyytgtmiyGPYKGE 501
Cdd:pfam00133  305 VGQ----------------RHNLEVINPVDDDGTFTEEA-----------------------------------PDFQGV 333

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   502 KVEQAKNKVKADMIAAG-----EAFVYNEPESqvmSRSGDDCIVSLEDQWYVDYGEesWKKQAIECLEGMQlFAPEVKNA 576
Cdd:pfam00133  334 YRFDARKKIVELLTEKGlllkiEPFTHSYPFC---WRSGTPIIPRATPQWFVRMDE--LADQALEAVEKVQ-FVPKSGEK 407

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   577 FegVLDWLKN---WAVCRTYGLGTRLP-W-----DEKYLVESLSD--STIYQSFYTIA--HLLFKDYYGNEIGPLgisad 643
Cdd:pfam00133  408 R--YFNWLANiqdWCISRQRWWGHPIPaWvskdtEEVVCRGELFElvAGRFEEEGSIKwlHREAKDKLGYGKGTL----- 480

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   644 QMTDEVFDYIFqhqDDVKNTNIPLPALQKLRREFEYFYPLDVSISGKDLIPNHLTFFIYTHVALF---PKKFwpkgIRAN 720
Cdd:pfam00133  481 EQDEDVLDTWF---SSGSWPFSTLGWPFVNTEEFKKFFPADMLLEGSDQTRGWFYRMIMLSTALTgsvPFKN----VLVH 553

                          730       740       750       760       770
                   ....*....|....*....|....*....|....*....|....*....|
gi 768897425   721 GHLM-LNNSKMSKSTGNFMTLEQTVEKFGADAARIAFADAgDTVEDANFD 769
Cdd:pfam00133  554 GLVRdEQGRKMSKSLGNVIDPLDVIDKYGADALRLWLANS-DYGRDINLS 602
Ile_Leu_Val_MetRS_core cd00668
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ...
 540-753 1.91e-27

catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.


Pssm-ID: 185674 [Multi-domain]  Cd Length: 312  Bit Score: 114.05  E-value: 1.91e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  540 VSLEDQWYVDYGEesWKKQAIECLEGMQLFAPEVKNAFEGVLDWLKNWAVCRTYGLGTRLPwdeKYLVESLSDSTIYqsf 619
Cdd:cd00668   136 VRITEQWFFDMPK--FKEKLLKALRRGKIVPEHVKNRMEAWLESLLDWAISRQRYWGTPLP---EDVFDVWFDSGIG--- 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  620 ytiahllfkdyygneigPLGIsadqmtdevFDYIFQHqddvkntniplpalqklrREFEYFYPLDVSISGKDLIPNHLTF 699
Cdd:cd00668   208 -----------------PLGS---------LGYPEEK------------------EWFKDSYPADWHLIGKDILRGWANF 243

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 768897425  700 FIYTHVALFpKKFWPKGIRANGHLMLNNS-KMSKSTGNFMTLEQTVEKFGADAAR 753
Cdd:cd00668   244 WITMLVALF-GEIPPKNLLVHGFVLDEGGqKMSKSKGNVIDPSDVVEKYGADALR 297
valS PRK13208
valyl-tRNA synthetase; Reviewed
 16-941 1.56e-19

valyl-tRNA synthetase; Reviewed


Pssm-ID: 237306 [Multi-domain]  Cd Length: 800  Bit Score: 94.49  E-value: 1.56e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   16 LIAIEKKYQKIWAEE--HQFEIDAP----SIDDEPitmdseelhrkypkfmssmayPYMNGVMHAGHCFTLSKVEFSIGF 89
Cdd:PRK13208   12 PEELEEKWQKIWEEEgtYKFDPDERkpvySIDTPP---------------------PTVSGSLHIGHVFSYTHTDFIARY 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   90 ERMNGKRALFPLGFHCTGMPIlacadklkreaELFGKNFDNVPAEEeeikeetpaekdhedvtkfkakkskaaakkgrgk 169
Cdd:PRK13208   71 QRMRGYNVFFPQGWDDNGLPT-----------ERKVEKYYGIRKDD---------------------------------- 105

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  170 yqfeimlqlgIPREEIIKfadakywltyfppLCESDC-----------TSLGARIDWRRSFVTTDanPYY-----DAFIR 233
Cdd:PRK13208  106 ----------ISREEFIE-------------LCRELTdedekkfrelwRRLGLSVDWSLEYQTIS--PEYrrisqKSFLD 160

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  234 wqmnkLKAAGKIKFGERYTIYSEKDG----QACMDHDRQSGEGVtpqeYIGVKIEALEfaddaakiidsssdldkskkfY 309
Cdd:PRK13208  161 -----LYKKGLIYRAEAPVLWCPRCEtaiaQAEVEYREREGKLN----YIKFPVEDGE---------------------E 210

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  310 FVAATLRPETMYGqtCC--FVSPtieygifdaGDsyfittERafknmsYQKLTPKRgfykpiVTVP--GKafigtkihap 385
Cdd:PRK13208  211 IEIATTRPELLPA--CVavVVHP---------DD------ER------YKHLVGKT------AIVPlfGV---------- 251

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  386 qsvypELRILPMETVIATKGTGVVtcvpsnspddYITTkdllhkpeyygikpewidheivpimhtekYGDLTAKAIVeek 465
Cdd:PRK13208  252 -----EVPILADPLVDPDFGTGAV----------MICT-----------------------------FGDKTDVTWW--- 284

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  466 kiqspKDKNLlaeAKKIAYKEDyytGTM--IYGPYKGEKVEQAKNKVKADMIAAGeaFVYnEPES-----QVMSRsgddC 538
Cdd:PRK13208  285 -----RELNL---PTRIIIDED---GRMteAAGKLAGLTIEEARKKIVEDLKSGG--LLG-KQEPikhnvKFCER----C 346

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  539 -----IVSlEDQWYVDYGEesWKKQAIECLEGMQlFAPE-----VKNAFEGvLDWlkNWAVCRTYGLGTRLP-W------ 601
Cdd:PRK13208  347 dtpleILV-TRQWFIKVLD--LKEELLERGKEIN-WYPEhmrvrLENWIEG-LNW--DWCISRQRYFGTPIPvWyckdcg 419

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  602 ------DEKYLVESLSDstiyqsfytiahllfkdyygneiGPLGISADQMTDEVF--DyifqhqDDVKNT----NI-PLP 668
Cdd:PRK13208  420 hpilpdEEDLPVDPTKD-----------------------EPPGYKCPQCGSPGFegE------TDVMDTwatsSItPLI 470

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  669 ALQKLRRE--FEYFYPLDVSISGKDLIPnhlTFFIYTHV---ALFPKKFWpKGIRANGH-LMLNNSKMSKSTGNFMTLEQ 742
Cdd:PRK13208  471 VTGWERDEdlFEKVFPMDLRPQGHDIIR---TWLFYTILrayLLTGKLPW-KNIMISGMvLDPDGKKMSKSKGNVVTPEE 546

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  743 TVEKFGADAARIAFADA--GDtveDANFDESNANAAilRLFNLKEW-----AEEITKESNLRTGEITDFFDIAFEHEMNA 815
Cdd:PRK13208  547 LLEKYGADAVRYWAASArlGS---DTPFDEKQVKIG--RRLLTKLWnasrfVLHFSADPEPDKAEVLEPLDRWILAKLAK 621

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  816 LIEKT---YEQYaltNYKNALK--YGLF--DFqaARDY--------YREASGvmHKDLIARY-----IETQALLLAPIAP 875
Cdd:PRK13208  622 VVEKAteaLENY---DFAKALEeiESFFwhVF--CDDYlelvksraYGEDEE--EEQKSARYtlytvLDTLLRLLAPFLP 694

                         970       980       990      1000      1010      1020
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 768897425  876 HFAEYIYREVLGNqtSVQNAKFPRASKP-VDKGVLAALDYLRNLQRSIRegegqALKKKKGKS--AEID 941
Cdd:PRK13208  695 FITEEVWSWLYGG--SVHRASWPEPDEElIDEEDEELGELAKEILSAVR-----KYKSEAGLSlnAPLK 756
LeuS COG0495
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ...
 720-900 1.06e-12

Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 440261 [Multi-domain]  Cd Length: 826  Bit Score: 72.39  E-value: 1.06e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  720 NGHLMLNNSKMSKSTGNFMTLEQTVEKFGADAAR--IAFadAGDTVEDANFDESNANAA---ILRLFNLkewAEEITKES 794
Cdd:COG0495   580 DGVVIGGIEKMSKSKGNVVDPDEIIEKYGADTLRlfEMF--AGPPERDLEWSDSGVEGAyrfLNRVWRL---VVDEAEAL 654

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  795 NLRTGEITDfFDIAFEHEMNALIEKT---YEQY-------ALTNYKNALKYGLFDFQAARDYYREAsgvmhkdliaryIE 864
Cdd:COG0495   655 KLDVADLSE-ADKELRRALHKTIKKVtedIERLrfntaiaALMELVNALYKAKDSGEADRAVLREA------------LE 721

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 768897425  865 TQALLLAPIAPHFAEYIYrEVLGNQTSVQNAKFPRA 900
Cdd:COG0495   722 TLVLLLAPFAPHIAEELW-ERLGHEGSVADAPWPEA 756
Anticodon_1 pfam08264
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ...
 806-950 1.32e-12

Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.


Pssm-ID: 400523 [Multi-domain]  Cd Length: 141  Bit Score: 66.27  E-value: 1.32e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   806 DIAFEHEMNALIEKTYEQYALTNYKNALKYGLFDFQAAR-DYYREAS---------GVMHKDLIARYIETQALLLAPIAP 875
Cdd:pfam08264    1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFWNDLsDWYLELIkdrlygeepDSRAQTTLYEVLETLLRLLAPFMP 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 768897425   876 HFAEYIYREvlgnqTSVQNAKFPRASKPVDKGVLAALDYLRNLQRSIRegegqALKKKKGksaeIDASKPVKLTL 950
Cdd:pfam08264   81 FITEELWQK-----ESIHLAPWPEDAELEEAELEEAFELRQEIVQAIR-----KLRSELK----IKKSLPLEVVI 141
ValRS_core cd00817
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ...
 530-768 2.98e-09

catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.


Pssm-ID: 185677 [Multi-domain]  Cd Length: 382  Bit Score: 60.34  E-value: 2.98e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  530 VMSRSGDDCIVSLEDQWYVDYGEEswKKQAIECLEGMQL-FAPEvkNAFEGVLDWLKN---WAVCRTYGLGTRLP-W--- 601
Cdd:cd00817   155 VCSRSGDVIEPLLKPQWFVKVKDL--AKKALEAVKEGDIkFVPE--RMEKRYENWLENirdWCISRQLWWGHRIPaWyck 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  602 DEKYLVESLSDstiyQSFYTIAHLLFKDYYGneigplGISADQMTDeVFD----------YIFQHQDDVKntniplpalq 671
Cdd:cd00817   231 DGGHWVVAREE----DEAIDKAAPEACVPCG------GEELKQDED-VLDtwfssslwpfSTLGWPEETK---------- 289

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  672 klrrEFEYFYPLDVSISGKDLIpnhltFFIYTHVALFPKKF-----WpKGIRANGhLML--NNSKMSKSTGNFMTLEQTV 744
Cdd:cd00817   290 ----DLKKFYPTSLLVTGHDII-----FFWVARMIMRGLKLtgklpF-KEVYLHG-LVRdeDGRKMSKSLGNVIDPLDVI 358

                         250       260
                  ....*....|....*....|....
gi 768897425  745 EKFGADAARIAFADAGDTVEDANF 768
Cdd:cd00817   359 DGYGADALRFTLASAATQGRDINL 382
valS PRK05729
valyl-tRNA synthetase; Reviewed
 676-950 4.62e-09

valyl-tRNA synthetase; Reviewed


Pssm-ID: 235582 [Multi-domain]  Cd Length: 874  Bit Score: 60.50  E-value: 4.62e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  676 EFEYFYPLDVSISGKDLIpnhltFF--------------------IYTHvALfpkkfwpkgIR-ANGHlmlnnsKMSKST 734
Cdd:PRK05729  467 DLKRFYPTSVLVTGFDII-----FFwvarmimmglhftgqvpfkdVYIH-GL---------VRdEQGR------KMSKSK 525

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  735 GNF---MTLeqtVEKFGADAAR---IAFADAGdtvEDANFDESNA-----------NAAILRLFNLKEWAEEITKESNLR 797
Cdd:PRK05729  526 GNVidpLDL---IDKYGADALRftlAALASPG---RDIRFDEERVegyrnfanklwNASRFVLMNLEGADVGELPDPEEL 599

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  798 TGEitdffDIAFEHEMNALIEKT---YEQYALTNYKNALkYGLF--DFQaarDYYREASgvmhKDLI--ARYIETQALLL 870
Cdd:PRK05729  600 SLA-----DRWILSRLNRTVAEVteaLDKYRFDEAARAL-YEFIwnEFC---DWYLELA----KPVLqeAAKRATRATLA 666

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  871 A----------PIAPHFAEYIYREV--LGNQTSVQNAKFPRASKPVDKGVLAALDYLRNLQRSIRegegqALKKKKGksa 938
Cdd:PRK05729  667 YvleqilrllhPFMPFITEELWQKLapLGIEESIMLAPWPEADEAIDEAAEAEFEWLKELITAIR-----NIRAEMN--- 738

                         330
                  ....*....|..
gi 768897425  939 eIDASKPVKLTL 950
Cdd:PRK05729  739 -IPPSKKLPLLL 749
tRNA-synt_1g pfam09334
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
 418-768 6.11e-08

tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.


Pssm-ID: 401322 [Multi-domain]  Cd Length: 387  Bit Score: 56.14  E-value: 6.11e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   418 DDYITTKDLLHkpeyygikpewidHEIVpimhTEKYGDLTAKAIVEEKKIQ---SPKDKNLLAEAkkiaykedYYTGTMI 494
Cdd:pfam09334   86 DDYGRTTSERH-------------HELV----QEFFLKLYENGYIYEKEIEqfyCPSDERFLPDR--------YVEGTCP 140

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   495 YGPY---KGEKVEQAKNKVkadmiaagEAFVYNEPESQVmsrSGDDCIVSLEDQWYVDYGEesWKKQAIECLEGMQLFAP 571
Cdd:pfam09334  141 HCGSedaRGDQCENCGRHL--------EPTELINPKCVI---CGTTPEVKETEHYFFDLSK--FQDKLREWIEENNPEWP 207

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   572 EvkNAFEGVLDWLKN----WAVCRTYGLGTRLPWDEKYLVESLSDSTI-YQSFytiahllFKDYYGNEigplgisadqmt 646
Cdd:pfam09334  208 E--NVKNMVLEWLKEglkdRAISRDLDWGIPVPGAEGKVFYVWLDAPIgYISA-------TKELSGNE------------ 266

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   647 devfdyifqhqddvkntniplpalqklrREFEYFYPLD-----VSISGKDLIPNHLTFF-IYTHVALFPKkfwPKGIRAN 720
Cdd:pfam09334  267 ----------------------------EKWKEWWPNDpdtelVHFIGKDIIYFHTIFWpAMLLGAGYRL---PTTVFAH 315

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*...
gi 768897425   721 GHLMLNNSKMSKSTGNFMTLEQTVEKFGADAARIAFADAGDTVEDANF 768
Cdd:pfam09334  316 GYLTYEGGKMSKSRGNVVWPSEALDRFPPDALRYYLARNRPETKDTDF 363
IleS COG0060
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ...
 729-933 1.30e-07

Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439830 [Multi-domain]  Cd Length: 931  Bit Score: 55.86  E-value: 1.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  729 KMSKSTGNFMTLEQTVEKFGADAARIAFAdAGDTVEDANFDEsnanaailrlfnlkewaeEITKES--NLRT-------- 798
Cdd:COG0060   603 KMSKSLGNVVDPQEVIDKYGADILRLWVA-SSDYWGDLRFSD------------------EILKEVrdVYRRlrntyrfl 663

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  799 -GEITDF----FDIAFE----------HEMNALIEKT---YEQYALTNYKNALkyglFDF----------QAARD-YYRE 849
Cdd:COG0060   664 lANLDDFdpaeDAVPYEdlpeldrwilSRLNELIKEVteaYDNYDFHRAYRAL----HNFcvedlsnwylDISKDrLYTE 739

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  850 AsgvmhKDLIAR-------Y--IETQALLLAPIAPHFAEYIYRE-VLGNQTSVQNAKFPRA-SKPVDKGVLAALDYLRNL 918
Cdd:COG0060   740 A-----ADSLDRraaqttlYevLETLVRLLAPILPFTAEEIWQNlPGEAEESVHLADWPEVdEELIDEELEAKWDLVREV 814

                         250
                  ....*....|....*
gi 768897425  919 QRSIREGEGQALKKK 933
Cdd:COG0060   815 RSAVLKALEAARKEK 829
CysRS_core cd00672
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ...
 683-756 2.19e-07

catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.


Pssm-ID: 173899 [Multi-domain]  Cd Length: 213  Bit Score: 52.58  E-value: 2.19e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 768897425  683 LDVSISGKDLIPNHLTFFIYTHVALFPKKF---WPKgiraNGHLMLNNSKMSKSTGNFMTLEQTVEKFGADAARIAF 756
Cdd:cd00672   129 FDIHGGGVDLIFPHHENEIAQSEAATGKPFaryWLH----TGHLTIDGEKMSKSLGNFITVRDALKKYDPEVLRLAL 201
CysS COG0215
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ...
 720-864 4.08e-07

Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439985 [Multi-domain]  Cd Length: 465  Bit Score: 53.95  E-value: 4.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  720 NGHLMLNNSKMSKSTGNFMTLEQTVEKFGADAAR-----------IAFADagDTVEDanfdesnANAAILRLFNLKEWAE 788
Cdd:COG0215   256 NGFLTVNGEKMSKSLGNFFTVRDLLKKYDPEVLRffllsahyrspLDFSE--EALEE-------AEKALERLYNALRRLE 326

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  789 EITKESNLRTGEITDF-----------FDIA------FE--HEMNALIEKTYEQYALTNYKNALKY-----GLFDfQAAR 844
Cdd:COG0215   327 EALGAADSSAEEIEELreefiaamdddFNTPealavlFElvREINKALDEGEDKAALAALAALLRAlggvlGLLL-LEPE 405

                         170       180
                  ....*....|....*....|
gi 768897425  845 DYYREASGVMHKDLIARYIE 864
Cdd:COG0215   406 AWQGAAEDELLDALIEALIE 425
tRNA-synt_1e pfam01406
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA ...
 677-759 1.01e-05

tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA synthetases.


Pssm-ID: 396128 [Multi-domain]  Cd Length: 301  Bit Score: 48.90  E-value: 1.01e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   677 FEYF-YPLDVSISGKDLIPNHLTFFIYTHVALFPK---KFWPKgiraNGHLMLNNSKMSKSTGNFMTLEQTVEKFGADAA 752
Cdd:pfam01406  201 RKYLgDQIDIHGGGIDLAFPHHENEIAQSEAAFDKqlaNYWLH----NGHVMIDGEKMSKSLGNFFTIRDVLKRYDPEIL 276


                   ....*..
gi 768897425   753 RIAFADA 759
Cdd:pfam01406  277 RYFLLSV 283
metG PRK00133
methionyl-tRNA synthetase; Reviewed
 689-906 1.15e-05

methionyl-tRNA synthetase; Reviewed


Pssm-ID: 234655 [Multi-domain]  Cd Length: 673  Bit Score: 49.38  E-value: 1.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  689 GKDLIPNHltffiythvALFpkkfWP---KG--------IRANGHLMLNNSKMSKSTGNFMTLEQTVEKFGADAARIAFA 757
Cdd:PRK00133  291 GKDIIYFH---------TLF----WPamlEGagyrlptnVFAHGFLTVEGAKMSKSRGTFIWARTYLDHLDPDYLRYYLA 357

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  758 -DAGDTVEDANfdesnanaailrlFNLKEWAEEITKE-----SNL--RT-GEITDFF---------DIAFEHEMNALIEK 819
Cdd:PRK00133  358 aKLPETIDDLD-------------FNWEDFQQRVNSElvgkvVNFasRTaGFINKRFdgklpdalaDPELLEEFEAAAEK 424

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  820 T---YEQYaltNYKNAL-----------KYglFDFQA----ARDYYREASGVMHKDL-IARYIetqALLLAPIAPHFAEY 880
Cdd:PRK00133  425 IaeaYEAR---EFRKALreimaladfanKY--VDDNEpwklAKQDGERLQAVCSVGLnLFRAL---AIYLKPVLPELAER 496

                         250       260
                  ....*....|....*....|....*..
gi 768897425  881 IyREVLGNQTSV-QNAKFPRASKPVDK 906
Cdd:PRK00133  497 A-EAFLNLEELTwDDAQQPLAGHPINK 522
PLN02224 PLN02224
methionine-tRNA ligase
 647-885 2.53e-05

methionine-tRNA ligase


Pssm-ID: 177869 [Multi-domain]  Cd Length: 616  Bit Score: 48.17  E-value: 2.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  647 DEVFDYIFQHQDDVKNtniplpalQKLRREFEYFYPLDVSISGKDLIPNHLTFfiYTHVALFPKKFWPKGIRANGHLMLN 726
Cdd:PLN02224  294 DALLGYISALTEDNKQ--------QNLETAVSFGWPASLHLIGKDILRFHAVY--WPAMLMSAGLELPKMVFGHGFLTKD 363

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  727 NSKMSKSTGNFMTLEQTVEKFGADAAR------IAFADAGDTVEDANFDESNANAA--ILRLFNLKEWAEEITKESNLRT 798
Cdd:PLN02224  364 GMKMGKSLGNTLEPFELVQKFGPDAVRyfflreVEFGNDGDYSEDRFIKIVNAHLAntIGNLLNRTLGLLKKNCESTLVE 443

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  799 GEITDFFDIAFEHEMNALIEK---TYEQYALTNYKNA-LKYG----LFDFQAARDYYREASGV----MHKDL--IARYIE 864
Cdd:PLN02224  444 DSTVAAEGVPLKDTVEKLVEKaqtNYENLSLSSACEAvLEIGnagnTYMDQRAPWFLFKQGGVsaeeAAKDLviILEVMR 523

                         250       260
                  ....*....|....*....|.
gi 768897425  865 TQALLLAPIAPHFAEYIYREV 885
Cdd:PLN02224  524 VIAVALSPIAPCLSLRIYSQL 544
PRK11893 PRK11893
methionyl-tRNA synthetase; Reviewed
 668-883 2.75e-05

methionyl-tRNA synthetase; Reviewed


Pssm-ID: 237012 [Multi-domain]  Cd Length: 511  Bit Score: 47.95  E-value: 2.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  668 PALQKLRREFEYFYPLDVSISGKDLIPNHLtffIYthvalfpkkfW-----------PKGIRANGHLMLNNSKMSKSTGN 736
Cdd:PRK11893  240 DDEELLAELFNKYWPADVHLIGKDILRFHA---VY----------WpaflmaaglplPKRVFAHGFLTLDGEKMSKSLGN 306

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  737 FMTLEQTVEKFGADAAR------IAFADAGDTVEDANFDESNANAA------ILRLFN-LKEWAEEITKESNLRTGEitd 803
Cdd:PRK11893  307 VIDPFDLVDEYGVDAVRyfllreIPFGQDGDFSREAFINRINADLAndlgnlAQRTLSmIAKNFDGKVPEPGALTEA--- 383

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  804 ffDIAFEHEMNALIEKTYEQYALTNYKNALKY---------GLFDFQA----ARDYYREASGVMHKDLiaRYIETQALLL 870
Cdd:PRK11893  384 --DEALLEAAAALLERVRAAMDNLAFDKALEAilalvraanKYIDEQApwslAKTDPERLATVLYTLL--EVLRGIAVLL 459

                         250
                  ....*....|...
gi 768897425  871 APIAPHFAEYIYR 883
Cdd:PRK11893  460 QPVMPELAAKILD 472
ValRS_core cd00817
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ...
 57-109 2.98e-05

catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.


Pssm-ID: 185677 [Multi-domain]  Cd Length: 382  Bit Score: 47.63  E-value: 2.98e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 768897425   57 PKFMSSMAYPYMNGVMHAGHCFTLSKVEFSIGFERMNGKRALFPLGFHCTGMP 109
Cdd:cd00817     1 PVFVIDTPPPNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIA 53
PRK12267 PRK12267
methionyl-tRNA synthetase; Reviewed
 677-772 1.53e-04

methionyl-tRNA synthetase; Reviewed


Pssm-ID: 237028 [Multi-domain]  Cd Length: 648  Bit Score: 45.95  E-value: 1.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  677 FEYFYPLDVSISGKDLIPNHLtffIYthvalfpkkfWP-----------KGIRANGHLMLNNSKMSKSTGNFMTLEQTVE 745
Cdd:PRK12267  249 FKKFWPADVHLVGKDILRFHA---IY----------WPimlmalglplpKKVFAHGWWLMKDGKMSKSKGNVVDPEELVD 315

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 768897425  746 KFGADAAR------IAFADAGDTVEDA-----NFDESN 772
Cdd:PRK12267  316 RYGLDALRyyllreVPFGSDGDFSPEAlveriNSDLAN 353
PTZ00399 PTZ00399
cysteinyl-tRNA-synthetase; Provisional
 721-757 3.79e-04

cysteinyl-tRNA-synthetase; Provisional


Pssm-ID: 240402 [Multi-domain]  Cd Length: 651  Bit Score: 44.64  E-value: 3.79e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 768897425  721 GHLMLNNSKMSKSTGNFMTLEQTVEKFGADAARIAFA 757
Cdd:PTZ00399  307 GHLHIKGLKMSKSLKNFITIRQALSKYTARQIRLLFL 343
cysS PRK14536
cysteinyl-tRNA synthetase; Provisional
 684-814 4.04e-04

cysteinyl-tRNA synthetase; Provisional


Pssm-ID: 184731 [Multi-domain]  Cd Length: 490  Bit Score: 44.14  E-value: 4.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  684 DVSISGKDLIPNHLTFFIYTHVALFPKKfWPKGIRANGHLMLNNSKMSKSTGNFMTLEQTVEK------------FGADA 751
Cdd:PRK14536  235 DIHIGGVDHIRVHHTNEIAQCEAATGKP-WVRYWLHHEFLLMNKGKMSKSAGQFLTLSSLQEKgfqpldyrffllGGHYR 313

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 768897425  752 ARIAFA-DAGDTVEDAN----------FDESNANAAILRLFNLKEWAEEITKESNLRTGEITDFFDIAFEHEMN 814
Cdd:PRK14536  314 SQLAFSwEALKTAKAARrslvrrvarvVDAARATTGSVRGTLAECAAERVAESRASESELLLTDFRAALEDDFS 387
Anticodon_Ia_Leu_BEm cd07958
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; ...
 849-884 1.11e-03

Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes bacterial and eukaryotic mitochondrial members, as well as LeuRS from the archaeal Halobacteria. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.


Pssm-ID: 153412 [Multi-domain]  Cd Length: 117  Bit Score: 39.90  E-value: 1.11e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 768897425  849 EASGVMHKDLIARYIETQALLLAPIAPHFAEYIYRE 884
Cdd:cd07958    81 KKKDAQHAAVLREALETLVLLLAPFAPHIAEELWEE 116
PLN02843 PLN02843
isoleucyl-tRNA synthetase
 20-121 2.17e-03

isoleucyl-tRNA synthetase


Pssm-ID: 215452 [Multi-domain]  Cd Length: 974  Bit Score: 42.07  E-value: 2.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425   20 EKKYQKIWAEEHQFEIDAPSIDDEPITmdseeLHRKyPkfmssmayPYMNGVMHAGHcfTLSKV--EFSIGFERMNGKRA 97
Cdd:PLN02843    9 EPEIQKLWEENQVYKRVSDRNNGESFT-----LHDG-P--------PYANGDLHIGH--ALNKIlkDFINRYQLLQGKKV 72

                          90       100
                  ....*....|....*....|....*...
gi 768897425   98 LFPLGFHCTGMPI----LACADKLKREA 121
Cdd:PLN02843   73 HYVPGWDCHGLPIelkvLQSLDQEARKE 100
Anticodon_Ia_Ile_ABEc cd07961
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ...
 864-918 6.95e-03

Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.


Pssm-ID: 153415 [Multi-domain]  Cd Length: 183  Bit Score: 38.69  E-value: 6.95e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 768897425  864 ETQALLLAPIAPHFAEYIY----REVLGNQTSVQNAKFPRA-SKPVDKGVLAALDYLRNL 918
Cdd:cd07961   119 LTLSRLMAPFTPFITEEIYqnlrRELGDAPESVHLLDWPEVdESLIDEELEEAMELVREI 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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