NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|756792123|gb|AJM91536|]
View 

hypothetical protein NPIRD3C_0318 [Nitrosopumilus piranensis]

Protein Classification

AcnX2 family protein( domain architecture ID 10788029)

AcnX2 family protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
AcnX2 COG1786
Mevalonate 5-phosphate dehydratase subunit 2, swiveling domain (modified mevalonate pathway) ...
 2-121 1.25e-50

Mevalonate 5-phosphate dehydratase subunit 2, swiveling domain (modified mevalonate pathway) [Lipid transport and metabolism];


:

Pssm-ID: 441392 [Multi-domain]  Cd Length: 131  Bit Score: 156.90  E-value: 1.25e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756792123   2 KVLVSGKVEGVVLKSKNAINFLGTVDKKTGIISDKNHDLYQKSIKDTILAFPSGVGSSVGAYTIYSIKSNNTAPLAMICM 81
Cdd:COG1786    5 RKIVGGKAEGEALVSDEPISFLGGVDPKTGVVIDPGHPLYGQSIAGKILVFPTGKGSTVGSYVLYELKKNGTAPAAIIFR 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 756792123  82 KADLTVATGCALANIPLVILSDEE-FSSINDGMKLSLDTDS 121
Cdd:COG1786   85 EADPILALGAIVAGIPLVDLFDEDpFEAIKTGDRVRVDADE 125
 
Name Accession Description Interval E-value
AcnX2 COG1786
Mevalonate 5-phosphate dehydratase subunit 2, swiveling domain (modified mevalonate pathway) ...
 2-121 1.25e-50

Mevalonate 5-phosphate dehydratase subunit 2, swiveling domain (modified mevalonate pathway) [Lipid transport and metabolism];


Pssm-ID: 441392 [Multi-domain]  Cd Length: 131  Bit Score: 156.90  E-value: 1.25e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756792123   2 KVLVSGKVEGVVLKSKNAINFLGTVDKKTGIISDKNHDLYQKSIKDTILAFPSGVGSSVGAYTIYSIKSNNTAPLAMICM 81
Cdd:COG1786    5 RKIVGGKAEGEALVSDEPISFLGGVDPKTGVVIDPGHPLYGQSIAGKILVFPTGKGSTVGSYVLYELKKNGTAPAAIIFR 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 756792123  82 KADLTVATGCALANIPLVILSDEE-FSSINDGMKLSLDTDS 121
Cdd:COG1786   85 EADPILALGAIVAGIPLVDLFDEDpFEAIKTGDRVRVDADE 125
PRK03955 PRK03955
DUF126 domain-containing protein;
2-121 1.88e-39

DUF126 domain-containing protein;


Pssm-ID: 179684 [Multi-domain]  Cd Length: 131  Bit Score: 128.55  E-value: 1.88e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756792123   2 KVLVSGKVEGVVLKSKNAINFLGTVDKKTGIISDKNHDLYQKSIKDTILAFPSGVGSSVGAYTIYSIKSNNTAPLAMICM 81
Cdd:PRK03955   6 RIISKGKAEGEVIVSKKPISFLGGVDPETGIVIDKEHDLYGESIKGKILVFPHGKGSTVGSYVIYQLAKNGTAPKAIINL 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 756792123  82 KADLTVATGCALANIPLVilSDEEFSSINDGMKLSLDTDS 121
Cdd:PRK03955  86 EAEPIVATGAIISGIPLV--DKVDISKLKDGDRVVVDGDE 123
AcnX_swivel cd01356
Putative Aconitase X swivel domain. It is predicted by comparative genomic analysis. The ...
 4-113 8.46e-35

Putative Aconitase X swivel domain. It is predicted by comparative genomic analysis. The proteins are mainly found in archaea and proteobacteria. They are distantly related to Aconitase family of proteins by sequence similarity and seconary structure prediction. The functions have not yet been experimentally characterized. Thus, the prediction should be treated with caution.


Pssm-ID: 238658  Cd Length: 123  Bit Score: 116.65  E-value: 8.46e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756792123   4 LVSGKVEGVVLKSKNAINFLGTVDKKTGIISDKNHDLYQKSIKDTILAFPSGVGSSVGAYTIYSIKSNNTAPLAMICMKA 83
Cdd:cd01356    1 IVRGRVEGEALVSREPLSFWGGVDPETGKVIDPHHPLYGESIAGKVLVLPGGKGSTVGSYVLYELARNGTAPAAIVFEEA 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 756792123  84 DLTVATGCALANIPLVI-LSDEEFSSINDGM 113
Cdd:cd01356   81 EPILAAGAILAGIPLVDsLPEVLFEALKDGD 111
AcnX_swivel_put pfam01989
Aconitase X swivel domain; This is a putative aconitase X swivel domain, which has been ...
 26-99 3.00e-32

Aconitase X swivel domain; This is a putative aconitase X swivel domain, which has been predicted by comparative genomic analysis. The domain is mainly found in archaeal and proteobacterial proteins. As such, the prediction should be treated with caution. One member of this entry from Aeropyrum pernix which has been annotated as a putative aconitase, has been characterized in vitro and catalyzes the dehydration of mevalonate 5-phosphate to form trans-anhydromevalonate 5-phosphate, a previously unknown intermediate, being involved in a "modified" mevalonate pathway.


Pssm-ID: 426551  Cd Length: 75  Bit Score: 108.71  E-value: 3.00e-32
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 756792123   26 VDKKTGIISDKNHDLYQKSIKDTILAFPSGVGSSVGAYTIYSIKSNNTAPLAMICMKADLTVATGCALANIPLV 99
Cdd:pfam01989   2 VDPETGVVIDPGHPLYGQSIAGKILVFPGGKGSTVGSYVLYELKKNGTAPAAIIFREADPILALGAIVAGIPLV 75
 
Name Accession Description Interval E-value
AcnX2 COG1786
Mevalonate 5-phosphate dehydratase subunit 2, swiveling domain (modified mevalonate pathway) ...
 2-121 1.25e-50

Mevalonate 5-phosphate dehydratase subunit 2, swiveling domain (modified mevalonate pathway) [Lipid transport and metabolism];


Pssm-ID: 441392 [Multi-domain]  Cd Length: 131  Bit Score: 156.90  E-value: 1.25e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756792123   2 KVLVSGKVEGVVLKSKNAINFLGTVDKKTGIISDKNHDLYQKSIKDTILAFPSGVGSSVGAYTIYSIKSNNTAPLAMICM 81
Cdd:COG1786    5 RKIVGGKAEGEALVSDEPISFLGGVDPKTGVVIDPGHPLYGQSIAGKILVFPTGKGSTVGSYVLYELKKNGTAPAAIIFR 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 756792123  82 KADLTVATGCALANIPLVILSDEE-FSSINDGMKLSLDTDS 121
Cdd:COG1786   85 EADPILALGAIVAGIPLVDLFDEDpFEAIKTGDRVRVDADE 125
PRK03955 PRK03955
DUF126 domain-containing protein;
2-121 1.88e-39

DUF126 domain-containing protein;


Pssm-ID: 179684 [Multi-domain]  Cd Length: 131  Bit Score: 128.55  E-value: 1.88e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756792123   2 KVLVSGKVEGVVLKSKNAINFLGTVDKKTGIISDKNHDLYQKSIKDTILAFPSGVGSSVGAYTIYSIKSNNTAPLAMICM 81
Cdd:PRK03955   6 RIISKGKAEGEVIVSKKPISFLGGVDPETGIVIDKEHDLYGESIKGKILVFPHGKGSTVGSYVIYQLAKNGTAPKAIINL 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 756792123  82 KADLTVATGCALANIPLVilSDEEFSSINDGMKLSLDTDS 121
Cdd:PRK03955  86 EAEPIVATGAIISGIPLV--DKVDISKLKDGDRVVVDGDE 123
AcnX_swivel cd01356
Putative Aconitase X swivel domain. It is predicted by comparative genomic analysis. The ...
 4-113 8.46e-35

Putative Aconitase X swivel domain. It is predicted by comparative genomic analysis. The proteins are mainly found in archaea and proteobacteria. They are distantly related to Aconitase family of proteins by sequence similarity and seconary structure prediction. The functions have not yet been experimentally characterized. Thus, the prediction should be treated with caution.


Pssm-ID: 238658  Cd Length: 123  Bit Score: 116.65  E-value: 8.46e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756792123   4 LVSGKVEGVVLKSKNAINFLGTVDKKTGIISDKNHDLYQKSIKDTILAFPSGVGSSVGAYTIYSIKSNNTAPLAMICMKA 83
Cdd:cd01356    1 IVRGRVEGEALVSREPLSFWGGVDPETGKVIDPHHPLYGESIAGKVLVLPGGKGSTVGSYVLYELARNGTAPAAIVFEEA 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 756792123  84 DLTVATGCALANIPLVI-LSDEEFSSINDGM 113
Cdd:cd01356   81 EPILAAGAILAGIPLVDsLPEVLFEALKDGD 111
AcnX_swivel_put pfam01989
Aconitase X swivel domain; This is a putative aconitase X swivel domain, which has been ...
 26-99 3.00e-32

Aconitase X swivel domain; This is a putative aconitase X swivel domain, which has been predicted by comparative genomic analysis. The domain is mainly found in archaeal and proteobacterial proteins. As such, the prediction should be treated with caution. One member of this entry from Aeropyrum pernix which has been annotated as a putative aconitase, has been characterized in vitro and catalyzes the dehydration of mevalonate 5-phosphate to form trans-anhydromevalonate 5-phosphate, a previously unknown intermediate, being involved in a "modified" mevalonate pathway.


Pssm-ID: 426551  Cd Length: 75  Bit Score: 108.71  E-value: 3.00e-32
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 756792123   26 VDKKTGIISDKNHDLYQKSIKDTILAFPSGVGSSVGAYTIYSIKSNNTAPLAMICMKADLTVATGCALANIPLV 99
Cdd:pfam01989   2 VDPETGVVIDPGHPLYGQSIAGKILVFPGGKGSTVGSYVLYELKKNGTAPAAIIFREADPILALGAIVAGIPLV 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH