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Conserved domains on  [gi|744805106|gb|AJC83055|]
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MbtH-like protein (plasmid) [Rhizobium etli bv. phaseoli str. IE4803]

Protein Classification

MbtH family protein( domain architecture ID 10007125)

MbtH family protein may be required for the synthesis of antibiotics, siderophores or glycopeptidolipids

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MbtH COG3251
MbtH family protein, regulates adenylation domains of NRPSs [Secondary metabolites ...
 1-70 7.83e-26

MbtH family protein, regulates adenylation domains of NRPSs [Secondary metabolites biosynthesis, transport and catabolism];


:

Pssm-ID: 442482  Cd Length: 71  Bit Score: 89.93  E-value: 7.83e-26
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 744805106  1 MDNLEPRDDL-WIVVIDTEHHYSVWPQDKRIPVSWEAAGFAGSRQECLAHIREIWTDPRPLSLRSAMAADA 70
Cdd:COG3251   1 MSNPFDDDDGtFLVLVNDEGQYSLWPAFRAVPAGWRVVGGPGSREECLAYIEEHWTDMRPLSLREAMAEQA 71
 
Name Accession Description Interval E-value
MbtH COG3251
MbtH family protein, regulates adenylation domains of NRPSs [Secondary metabolites ...
 1-70 7.83e-26

MbtH family protein, regulates adenylation domains of NRPSs [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442482  Cd Length: 71  Bit Score: 89.93  E-value: 7.83e-26
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 744805106  1 MDNLEPRDDL-WIVVIDTEHHYSVWPQDKRIPVSWEAAGFAGSRQECLAHIREIWTDPRPLSLRSAMAADA 70
Cdd:COG3251   1 MSNPFDDDDGtFLVLVNDEGQYSLWPAFRAVPAGWRVVGGPGSREECLAYIEEHWTDMRPLSLREAMAEQA 71
MbtH pfam03621
MbtH-like protein; This domain is found in the MbtH protein as well as at the N terminus of ...
 1-52 4.27e-13

MbtH-like protein; This domain is found in the MbtH protein as well as at the N terminus of the antibiotic synthesis protein NIKP1. MbtH and its homologs were first noted in gene clusters involved in non-ribosomal peptides and other secondary metabolites by Quadri et al. This domain is about 70 amino acids long and contains 3 fully conserved tryptophan residues. The structure of the PA2412 protein shows it adopts a beta-beta-beta-alpha-alpha topology with the short C-terminal helix forming the tip of an overall arrowhead shape. MbtH proteins have been shown to be required for the synthesis of antibiotics, siderophores and glycopeptidolipids.


Pssm-ID: 427405  Cd Length: 53  Bit Score: 57.13  E-value: 4.27e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 744805106   1 MDN-LEPRDDLWIVVIDTEHHYSVWPQDKRIPVSWEAAGFAGSRQECLAHIRE 52
Cdd:pfam03621  1 MTNpFDDDDGTFLVLVNDEGQYSLWPAFAPVPAGWRVVGGPGSRQECLDYIEE 53
 
Name Accession Description Interval E-value
MbtH COG3251
MbtH family protein, regulates adenylation domains of NRPSs [Secondary metabolites ...
 1-70 7.83e-26

MbtH family protein, regulates adenylation domains of NRPSs [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442482  Cd Length: 71  Bit Score: 89.93  E-value: 7.83e-26
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 744805106  1 MDNLEPRDDL-WIVVIDTEHHYSVWPQDKRIPVSWEAAGFAGSRQECLAHIREIWTDPRPLSLRSAMAADA 70
Cdd:COG3251   1 MSNPFDDDDGtFLVLVNDEGQYSLWPAFRAVPAGWRVVGGPGSREECLAYIEEHWTDMRPLSLREAMAEQA 71
MbtH pfam03621
MbtH-like protein; This domain is found in the MbtH protein as well as at the N terminus of ...
 1-52 4.27e-13

MbtH-like protein; This domain is found in the MbtH protein as well as at the N terminus of the antibiotic synthesis protein NIKP1. MbtH and its homologs were first noted in gene clusters involved in non-ribosomal peptides and other secondary metabolites by Quadri et al. This domain is about 70 amino acids long and contains 3 fully conserved tryptophan residues. The structure of the PA2412 protein shows it adopts a beta-beta-beta-alpha-alpha topology with the short C-terminal helix forming the tip of an overall arrowhead shape. MbtH proteins have been shown to be required for the synthesis of antibiotics, siderophores and glycopeptidolipids.


Pssm-ID: 427405  Cd Length: 53  Bit Score: 57.13  E-value: 4.27e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 744805106   1 MDN-LEPRDDLWIVVIDTEHHYSVWPQDKRIPVSWEAAGFAGSRQECLAHIRE 52
Cdd:pfam03621  1 MTNpFDDDDGTFLVLVNDEGQYSLWPAFAPVPAGWRVVGGPGSRQECLDYIEE 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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