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Conserved domains on  [gi|728054109|gb|AIY67297|]
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hypothetical protein OM33_19830 [Pseudoalteromonas piratica]

Protein Classification

sensor histidine kinase( domain architecture ID 11461692)

sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to an external signal

CATH:  3.30.565.10
EC:  2.7.13.3
PubMed:  10637609|10339418
SCOP:  4001957

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
LytS COG3275
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
4-330 7.71e-46

Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];


:

Pssm-ID: 442506 [Multi-domain]  Cd Length: 352  Bit Score: 159.26  E-value: 7.71e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728054109   4 AINYLVLFVFSLLIVLYAALLTTPKGQNLNIHLDAPFWIFLQCVIAQWLTLKIYHVIKQGNSSITMHIAKVFFASNLVFS 83
Cdd:COG3275   12 LLLLLLLLLLLSLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728054109  84 SLVTALVLALETVIGIQKIDTMHMIATLGMNALLHALIGAYSLAFELVTRLQGQQLILAKKEKALLDSQVKTLQQHIDPH 163
Cdd:COG3275   92 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLILILLALLLSLQEEELELEELEKELLEAELKALKAQINPH 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728054109 164 FLFNNLNVLSALIVKDPDEAEEYLAQFSDIYRYILEHKSKNLVPLSHELAFANHYMALINTRFNGAYTLNVTQGEGRNTA 243
Cdd:COG3275  172 FLFNTLNSIYSLIREDPEKARELLLKLSDLLRYSLYESDKELVPLEEELEFLENYLELEKLRFGDRLQVEIDIDEELLDL 251
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728054109 244 EIIPCALQLAIENVVKHNAASSDNPLEITIDIQSD----CIVITN--PLRLKEFKAHSSKIGLTHLNAQCQAIFNQ--SI 315
Cdd:COG3275  252 LIPPLLLQPLVENAIKHGISSKEGGGTISISIEVEgdrlVIEVENngVGIQPKKKKKGSGIGLKNVRERLELLYGDkySL 331
                        330
                 ....*....|....*...
gi 728054109 316 LVDERNG---CFSLTLPL 330
Cdd:COG3275  332 EIESTDGggtKVTLKIPL 349
 
Name Accession Description Interval E-value
LytS COG3275
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
4-330 7.71e-46

Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];


Pssm-ID: 442506 [Multi-domain]  Cd Length: 352  Bit Score: 159.26  E-value: 7.71e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728054109   4 AINYLVLFVFSLLIVLYAALLTTPKGQNLNIHLDAPFWIFLQCVIAQWLTLKIYHVIKQGNSSITMHIAKVFFASNLVFS 83
Cdd:COG3275   12 LLLLLLLLLLLSLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728054109  84 SLVTALVLALETVIGIQKIDTMHMIATLGMNALLHALIGAYSLAFELVTRLQGQQLILAKKEKALLDSQVKTLQQHIDPH 163
Cdd:COG3275   92 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLILILLALLLSLQEEELELEELEKELLEAELKALKAQINPH 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728054109 164 FLFNNLNVLSALIVKDPDEAEEYLAQFSDIYRYILEHKSKNLVPLSHELAFANHYMALINTRFNGAYTLNVTQGEGRNTA 243
Cdd:COG3275  172 FLFNTLNSIYSLIREDPEKARELLLKLSDLLRYSLYESDKELVPLEEELEFLENYLELEKLRFGDRLQVEIDIDEELLDL 251
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728054109 244 EIIPCALQLAIENVVKHNAASSDNPLEITIDIQSD----CIVITN--PLRLKEFKAHSSKIGLTHLNAQCQAIFNQ--SI 315
Cdd:COG3275  252 LIPPLLLQPLVENAIKHGISSKEGGGTISISIEVEgdrlVIEVENngVGIQPKKKKKGSGIGLKNVRERLELLYGDkySL 331
                        330
                 ....*....|....*...
gi 728054109 316 LVDERNG---CFSLTLPL 330
Cdd:COG3275  332 EIESTDGggtKVTLKIPL 349
His_kinase pfam06580
Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. ...
151-228 1.11e-22

Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. Two-component signal transduction systems such as those mediated by histidine kinase are integral parts of bacterial cellular regulatory processes, and are used to regulate the expression of genes involved in virulence. Members of this family often contain pfam02518 and/or pfam00672.


Pssm-ID: 461952 [Multi-domain]  Cd Length: 79  Bit Score: 89.81  E-value: 1.11e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 728054109  151 SQVKTLQQHIDPHFLFNNLNVLSALIVKDPDEAEEYLAQFSDIYRYILEhKSKNLVPLSHELAFANHYMALINTRFNG 228
Cdd:pfam06580   1 AELKALQAQINPHFLFNTLNSISSLAIEDPEEAAEMILKLSDLLRYSLY-EGEELVTLEEELEFLENYLEIQKIRFGD 77
 
Name Accession Description Interval E-value
LytS COG3275
Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];
4-330 7.71e-46

Sensor histidine kinase, LytS/YehU family [Signal transduction mechanisms];


Pssm-ID: 442506 [Multi-domain]  Cd Length: 352  Bit Score: 159.26  E-value: 7.71e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728054109   4 AINYLVLFVFSLLIVLYAALLTTPKGQNLNIHLDAPFWIFLQCVIAQWLTLKIYHVIKQGNSSITMHIAKVFFASNLVFS 83
Cdd:COG3275   12 LLLLLLLLLLLSLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728054109  84 SLVTALVLALETVIGIQKIDTMHMIATLGMNALLHALIGAYSLAFELVTRLQGQQLILAKKEKALLDSQVKTLQQHIDPH 163
Cdd:COG3275   92 LLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLILILLALLLSLQEEELELEELEKELLEAELKALKAQINPH 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728054109 164 FLFNNLNVLSALIVKDPDEAEEYLAQFSDIYRYILEHKSKNLVPLSHELAFANHYMALINTRFNGAYTLNVTQGEGRNTA 243
Cdd:COG3275  172 FLFNTLNSIYSLIREDPEKARELLLKLSDLLRYSLYESDKELVPLEEELEFLENYLELEKLRFGDRLQVEIDIDEELLDL 251
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728054109 244 EIIPCALQLAIENVVKHNAASSDNPLEITIDIQSD----CIVITN--PLRLKEFKAHSSKIGLTHLNAQCQAIFNQ--SI 315
Cdd:COG3275  252 LIPPLLLQPLVENAIKHGISSKEGGGTISISIEVEgdrlVIEVENngVGIQPKKKKKGSGIGLKNVRERLELLYGDkySL 331
                        330
                 ....*....|....*...
gi 728054109 316 LVDERNG---CFSLTLPL 330
Cdd:COG3275  332 EIESTDGggtKVTLKIPL 349
His_kinase pfam06580
Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. ...
151-228 1.11e-22

Histidine kinase; This family represents a region within bacterial histidine kinase enzymes. Two-component signal transduction systems such as those mediated by histidine kinase are integral parts of bacterial cellular regulatory processes, and are used to regulate the expression of genes involved in virulence. Members of this family often contain pfam02518 and/or pfam00672.


Pssm-ID: 461952 [Multi-domain]  Cd Length: 79  Bit Score: 89.81  E-value: 1.11e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 728054109  151 SQVKTLQQHIDPHFLFNNLNVLSALIVKDPDEAEEYLAQFSDIYRYILEhKSKNLVPLSHELAFANHYMALINTRFNG 228
Cdd:pfam06580   1 AELKALQAQINPHFLFNTLNSISSLAIEDPEEAAEMILKLSDLLRYSLY-EGEELVTLEEELEFLENYLEIQKIRFGD 77
YesM COG2972
Sensor histidine kinase YesM [Signal transduction mechanisms];
5-285 1.20e-21

Sensor histidine kinase YesM [Signal transduction mechanisms];


Pssm-ID: 442211 [Multi-domain]  Cd Length: 445  Bit Score: 95.08  E-value: 1.20e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728054109   5 INYLVLFVFSLLIVLYAALLTTPKGQNLNIHLDAPFWIFLQCVIAQWLTLKIYHVIKQGNSSITMHIAKVFFASNLVFSS 84
Cdd:COG2972   91 LLLILLLSLLLLLALILLLALLLLLSILLLILGLLLIILLLLSLLGWTLVSLIPKSELFRGLFSLRRLILLIILLLLLLA 170
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728054109  85 LVTALVLALETVIGIQKI-DTMHMIATLGMNALL---HALIGAYSLAF-ELVTRLQGQQLILAKKEKALLDSQVKTLQQH 159
Cdd:COG2972  171 LLLSYLLSRSITRPIKRLkKAMKKVEKGDLVRLEvsgNDEIGILARSFnEMVERIKELIEEVYELELEKKEAELKALQAQ 250
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 728054109 160 IDPHFLFNNLNVLSALIV-KDPDEAEEYLAQFSDIYRYILEhKSKNLVPLSHELAFANHYMALINTRFNGAYTLNVTQGE 238
Cdd:COG2972  251 INPHFLFNTLNSIRWLAElEDPEEAEEMLEALSKLLRYSLS-KGDELVTLEEELELIKSYLEIQKLRFGDRLEVEIEIDE 329
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 728054109 239 GRNTAEIIPCALQLAIENVVKHNAASSDNPLEITIDIQSD----CIVITNP 285
Cdd:COG2972  330 ELLDLLIPKLILQPLVENAIEHGIEPKEGGGTIRISIRKEgdrlVITVEDN 380
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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