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Conserved domains on  [gi|695872405|gb|AIT19049|]
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alpha 2B adrenergic receptor, partial [Uperoleia mjobergii]

Protein Classification

G protein-coupled receptor family protein( domain architecture ID 705710)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tm_GPCRs super family cl28897
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
1-123 5.22e-89

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


The actual alignment was detected with superfamily member cd15322:

Pssm-ID: 475119 [Multi-domain]  Cd Length: 259  Bit Score: 261.80  E-value: 5.22e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKEEE 80
Cdd:cd15322   69 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKKSGQPEG 148
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 695872405  81 PKCKINEEKWYIISSCIGSFFAPCVIMVLVYIRIYQIAKKRTR 123
Cdd:cd15322  149 PICKINDEKWYIISSCIGSFFAPCLIMVLVYIRIYQIAKNREK 191
 
Name Accession Description Interval E-value
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
1-123 5.22e-89

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 261.80  E-value: 5.22e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKEEE 80
Cdd:cd15322   69 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKKSGQPEG 148
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 695872405  81 PKCKINEEKWYIISSCIGSFFAPCVIMVLVYIRIYQIAKKRTR 123
Cdd:cd15322  149 PICKINDEKWYIISSCIGSFFAPCLIMVLVYIRIYQIAKNREK 191
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
1-136 2.03e-36

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 127.41  E-value: 2.03e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405    1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKE-E 79
Cdd:pfam00001  54 GSALCKIVGALFVVNGYASILLLTAISIDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEgN 133
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 695872405   80 EPKCKIN------EEKWYIISSCIGSFFAPCVIMVLVYIRIYQIAKKRTRVPPSKRSNGEPEK 136
Cdd:pfam00001 134 VTVCFIDfpedlsKPVSYTLLISVLGFLLPLLVILVCYTLIIRTLRKSASKQKSSERTQRRRK 196
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
18-130 1.76e-07

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 50.16  E-value: 1.76e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405  18 SSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKEEEPKCKINEEK------WY 91
Cdd:PHA03087 124 NSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYTTKKDHETLICCMFYNNKtmnwklFI 203
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 695872405  92 IISSCIGSFFAPCVIMVLVYIRIYQIAKKRTRVPPSKRS 130
Cdd:PHA03087 204 NFEINIIGMLIPLTILLYCYSKILITLKGINKSKKNKKA 242
 
Name Accession Description Interval E-value
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
1-123 5.22e-89

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 261.80  E-value: 5.22e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKEEE 80
Cdd:cd15322   69 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKKSGQPEG 148
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 695872405  81 PKCKINEEKWYIISSCIGSFFAPCVIMVLVYIRIYQIAKKRTR 123
Cdd:cd15322  149 PICKINDEKWYIISSCIGSFFAPCLIMVLVYIRIYQIAKNREK 191
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
1-123 3.03e-77

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 231.75  E-value: 3.03e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKEEE 80
Cdd:cd15323   69 GQVWCNIYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKAIIVTVWLISAVISFPPLISMYRDPEGDVY 148
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 695872405  81 PKCKINEEKWYIISSCIGSFFAPCVIMVLVYIRIYQIAKKRTR 123
Cdd:cd15323  149 PQCKLNDETWYILSSCIGSFFAPCLIMILVYIRIYRVAKAREK 191
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
1-123 2.83e-74

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 224.42  E-value: 2.83e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKEE- 79
Cdd:cd15321   75 RKTWCEIYLALDVLFCTSSIVHLCAISLDRYWSVSRAIEYNSKRTPRRIKCIILIVWLIAAVISLPPLIYKGKQKDEQGg 154
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 695872405  80 EPKCKINEEKWYIISSCIGSFFAPCVIMVLVYIRIYQIAKKRTR 123
Cdd:cd15321  155 LPQCKLNEEAWYILSSSIGSFFAPCLIMILVYLRIYLIAKNREK 198
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
1-123 2.43e-73

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 221.83  E-value: 2.43e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESG-KEE 79
Cdd:cd15059   69 GSVWCEIWLALDVLFCTASIVNLCAISLDRYWSVTQAVEYNLKRTPRRAKAMIAAVWIISAVISLPPLFGWKDEQPwHGA 148
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 695872405  80 EPKCKINEEKWYIISSCIGSFFAPCVIMVLVYIRIYQIAKKRTR 123
Cdd:cd15059  149 EPQCELSDDPGYVLFSSIGSFYIPLLIMIIVYARIYRAAKRKER 192
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
1-123 1.41e-63

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 197.02  E-value: 1.41e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIekesgKEEE 80
Cdd:cd15324   69 GSTWCAFYLALDVLFCTSSIVHLCAISLDRYWSVTKAVSYNLKRTPKRIKRMIAVVWVISAVISFPPLLMT-----KHDE 143
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 695872405  81 PKCKINEEKWYIISSCIGSFFAPCVIMVLVYIRIYQIAKKRTR 123
Cdd:cd15324  144 WECLLNDETWYILSSCTVSFFAPGLIMILVYCKIYRVAKMREK 186
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
1-124 9.66e-53

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 169.28  E-value: 9.66e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLI-TIEKESGKEE 79
Cdd:cd14967   68 GPVLCRFWIALDVLCCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLPPLVgWRDETQPSVV 147
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 695872405  80 EPKCKINEEKWYIISSCIGSFFAPCVIMVLVYIRIYQIAKKRTRV 124
Cdd:cd14967  148 DCECEFTPNKIYVLVSSVISFFIPLLIMIVLYARIFRVARRELKA 192
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
1-123 6.17e-47

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 154.41  E-value: 6.17e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESgKEEE 80
Cdd:cd15064   69 GQVLCDIWISLDVTCCTASILHLCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSICISLPPLFGWRTPD-SEDP 147
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 695872405  81 PKCKINEEKWYIISSCIGSFFAPCVIMVLVYIRIYQIAKKRTR 123
Cdd:cd15064  148 SECLISQDIGYTIFSTFGAFYIPLLLMLILYWKIYRAAARERK 190
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
1-123 1.12e-45

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 151.27  E-value: 1.12e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKEsgKEEE 80
Cdd:cd15329   69 GEILCDVWISFDVLLCTASILNLCAISVDRYLVITRPLTYAVKRTPKRMALMIAIVWLLSALISIPPLFGWKNK--VNDP 146
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 695872405  81 PKCKINEEKWYIISSCIGSFFAPCVIMVLVYIRIYQIAKKRTR 123
Cdd:cd15329  147 GVCQVSQDFGYQIYATFGAFYIPLIVMLVLYYKIYRAAKSERK 189
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
1-123 3.51e-41

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 139.87  E-value: 3.51e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLIT-IEKESGKEE 79
Cdd:cd15060   69 GIHLCQMWLTCDILCCTASILNLCAIALDRYWAIHDPINYAQKRTLKRVLLMIVVVWALSALISVPPLIGwNDWPENFTE 148
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 695872405  80 EPKCKINEEKWYIISSCIGSFFAPCVIMVLVYIRIYQIAKKRTR 123
Cdd:cd15060  149 TTPCTLTEEKGYVIYSSSGSFFIPLLIMTIVYVKIFIATSKERR 192
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
1-123 2.24e-39

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 135.18  E-value: 2.24e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPlITIEKESGKEEE 80
Cdd:cd15067   69 GRDWCDVWHSFDVLASTASILNLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWICSALISFPA-IAWWRAVDPGPS 147
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 695872405  81 PK--CKINEEKWY-IISSCIgSFFAPCVIMVLVYIRIYQIAKKRTR 123
Cdd:cd15067  148 PPnqCLFTDDSGYlIFSSCV-SFYIPLVVMLFTYYRIYRAAAKEQK 192
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
1-123 1.51e-37

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 130.69  E-value: 1.51e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLI-------TIEK 73
Cdd:cd15063   69 GHTWCQIWLAVDVWMCTASILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSFVICFPPLVgwndgkdGIMD 148
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 695872405  74 ESGKEEEP-KCKINEEKWYIISSCIGSFFAPCVIMVLVYIRIYQIAKKRTR 123
Cdd:cd15063  149 YSGSSSLPcTCELTNGRGYVIYSALGSFYIPMLVMLFFYFRIYRAARMETK 199
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
1-123 3.69e-37

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 129.53  E-value: 3.69e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITiEKESGKEEE 80
Cdd:cd15333   73 GQVVCDIWLSSDITCCTASILHLCVIALDRYWAITDAVEYSKKRTPKRAAVMIALVWVISISISLPPFFW-RQAKAEEEV 151
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 695872405  81 PKCKINEEK-WYIISSCIGSFFAPCVIMVLVYIRIYQIAKKRTR 123
Cdd:cd15333  152 SECVVNTDHiLYTVYSTVGAFYIPTLLLIALYGRIYVEARARER 195
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
1-123 4.97e-37

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 128.94  E-value: 4.97e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKEEE 80
Cdd:cd15330   69 GQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAVLISLTWLIGFSISIPPMLGWRTPEDRSDP 148
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 695872405  81 PKCKINEEKWYIISSCIGSFFAPCVIMVLVYIRIYQIAKKRTR 123
Cdd:cd15330  149 DACTISKDPGYTIYSTFGAFYIPLILMLVLYGRIFKAAARERK 191
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
1-136 2.03e-36

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 127.41  E-value: 2.03e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405    1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKE-E 79
Cdd:pfam00001  54 GSALCKIVGALFVVNGYASILLLTAISIDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEgN 133
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 695872405   80 EPKCKIN------EEKWYIISSCIGSFFAPCVIMVLVYIRIYQIAKKRTRVPPSKRSNGEPEK 136
Cdd:pfam00001 134 VTVCFIDfpedlsKPVSYTLLISVLGFLLPLLVILVCYTLIIRTLRKSASKQKSSERTQRRRK 196
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
1-121 9.54e-36

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 125.54  E-value: 9.54e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQaIEYNLKRTPRRIKCIIFIVWVISAVISFPPLI---TIEKESGK 77
Cdd:cd15331   69 GPEVCDMWISMDVLCCTASILHLVAIALDRYWAVTN-IDYIRRRTAKRILIMIAVVWFVSLIISIAPLFgwkDEDDLDRV 147
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 695872405  78 EEEPKCKINEEKWYIISSCIGSFFAPCVIMVLVYIRIYQIAKKR 121
Cdd:cd15331  148 LKTGVCLISQDYGYTIFSTVGAFYVPLLLMIIIYWKIYQAAKRE 191
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
1-131 1.54e-33

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 120.47  E-value: 1.54e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKE-- 78
Cdd:cd00637   67 GDALCKLLGFLQSVSLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGyc 146
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 695872405  79 --EEPKCKINEEKWYIISSCIGSFFAPCVIMVLVYIRIYQIAKKRTRVPPSKRSN 131
Cdd:cd00637  147 ccCLCWPDLTLSKAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIRSSSSN 201
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
1-123 2.23e-33

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 120.13  E-value: 2.23e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLI----TIEKESG 76
Cdd:cd15051   69 GPVFCNIYISLDVMLCTASILNLFAISLDRYLAITAPLRYPSRVTPRRVAIALAAIWVVSLAVSFLPIHlgwnTPDGRVQ 148
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 695872405  77 KEEEP-KCKINEEKWYIISSCIGSFFAPCVIMVLVYIRIYQIAKKRTR 123
Cdd:cd15051  149 NGDTPnQCRFELNPPYVLLVAIGTFYLPLLIMCGVYLRIFRIAREQAK 196
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
1-123 4.65e-33

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 118.62  E-value: 4.65e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLItIEKESGKEEE 80
Cdd:cd15061   68 GSHLCDFWISLDVLLCTASILNLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVISLLITSPPLV-GPSWHGRRGL 146
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 695872405  81 PKCKINEEKWYIISSCIGSFFAPCVIMVLVYIRIYQIAKKRTR 123
Cdd:cd15061  147 GSCYYTYDKGYRIYSSMGSFFLPLLLMLFVYLRIFRVIAKERK 189
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
4-123 5.18e-33

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 119.46  E-value: 5.18e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   4 WCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLI--------TIEKES 75
Cdd:cd15057   72 FCDVWVSFDIMCSTASILNLCVISVDRYWAISSPFRYERRMTRRRAFIMIAVAWTLSALISFIPVQlgwhraddTSEALA 151
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 695872405  76 GKEEEPKCKINEEKWYIISSCIGSFFAPCVIMVLVYIRIYQIAKKRTR 123
Cdd:cd15057  152 LYADPCQCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIARRQIR 199
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
1-123 8.91e-33

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 118.22  E-value: 8.91e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKEEE 80
Cdd:cd15053   70 GPILCDIYIAMDVMCSTASIFNLCAISIDRYIAVTQPIKYARQKNSKRVLLTIAIVWVVSAAIACPLLFGLNNVPYRDPE 149
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 695872405  81 pKCKI-NEEkwYIISSCIGSFFAPCVIMVLVYIRIYqIAKKRTR 123
Cdd:cd15053  150 -ECRFyNPD--FIIYSSISSFYIPCIVMLLLYYRIF-RALRREK 189
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
1-123 2.61e-32

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 116.56  E-value: 2.61e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITieKESGKEEE 80
Cdd:cd15335   69 GYFICEIWLSVDMTCCTCSILHLCVIALDRYWAITDAIEYARKRTAKRAGLMILTVWTISIFISIPPLFW--RNHHDANI 146
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 695872405  81 P-KCKINEEKW-YIISSCIGSFFAPCVIMVLVYIRIYQIAKKRTR 123
Cdd:cd15335  147 PsQCIIQHDHViYTIYSTFGAFYIPLTLILILYYRIYHAASRERK 191
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
1-145 4.45e-32

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 117.07  E-value: 4.45e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPlITIEKESGKEEE 80
Cdd:cd15065   68 GETFCNIWISFDVMCSTASILNLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSALISFLP-IHLGWHRLSQDE 146
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405  81 PKCKINEEKWY------------IISSCIgSFFAPCVIMVLVYIRIYQIAKK---------RTRVPPSKRSNGEPEKKQN 139
Cdd:cd15065  147 IKGLNHASNPKpscaldlnptyaVVSSLI-SFYIPCLVMLLIYSRLYLYARKhvvniksqkLPSESGSKFQVPSLSSKHN 225

                 ....*.
gi 695872405 140 GLADQD 145
Cdd:cd15065  226 NQGVSD 231
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
1-120 9.42e-32

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 115.55  E-value: 9.42e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLI-----TIEKES 75
Cdd:cd15066   68 GYFMCDVWNSLDVYFSTASILHLCCISVDRYYAIVQPLEYPSKMTKRRVAIMLANVWISPALISFLPIFlgwytTEEHLQ 147
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 695872405  76 GKEEEP-KCKINEEKWY-IISSCIgSFFAPCVIMVLVYIRIYQIAKK 120
Cdd:cd15066  148 YRKTHPdQCEFVVNKIYaLISSSV-SFWIPCIVMIFTYYRIYLEAKR 193
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
1-123 1.14e-31

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 115.05  E-value: 1.14e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLkRTPRRIKCI-IFIVWVISAVISFPPLITIEKESGKEE 79
Cdd:cd15328   70 GRSLCQVWISFDVLCCTASIWNVTAIALDRYWSITRHLEYTL-RTRRRISNVmIALTWALSAVISLAPLLFGWGETYSED 148
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 695872405  80 EPKCKINEEKWYIISSCIGSFFAPCVIMVLVYIRIYQIAKKRTR 123
Cdd:cd15328  149 SEECQVSQEPSYTVFSTFGAFYLPLCVVLFVYWKIYKAAQKEKR 192
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
1-123 9.46e-30

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 110.27  E-value: 9.46e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIeKESGKEEE 80
Cdd:cd15062   69 GRIFCDVWAAVDVLCCTASIMSLCVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVLSLVISIGPLLGW-KEPAPADE 147
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 695872405  81 PKCKINEEKWYIISSCIGSFFAPCVIMVLVYIRIYQIAKKRTR 123
Cdd:cd15062  148 QACGVNEEPGYVLFSSLGSFYLPLAIILVMYCRVYVVAFKFSR 190
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
1-123 1.84e-29

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 110.23  E-value: 1.84e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKEEE 80
Cdd:cd15058   69 GNFWCELWTSVDVLCVTASIETLCVIAVDRYIAITRPLRYQVLLTKRRARVIVCVVWIVSALVSFVPIMNQWWRANDPEA 148
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 695872405  81 PKCKINEE--------KWYIISSCIgSFFAPCVIMVLVYIRIYQIAKKRTR 123
Cdd:cd15058  149 NDCYQDPTccdfrtnmAYAIASSVV-SFYIPLLIMIFVYARVFLIATRQLQ 198
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
1-132 2.53e-29

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 109.21  E-value: 2.53e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIeKESGKEEE 80
Cdd:cd15325   69 GRVFCNIWAAVDVLCCTASIMSLCIISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVLSLVISIGPLFGW-KEPAPEDE 147
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 695872405  81 PKCKINEEKWYIISSCIGSFFAPCVIMVLVYIRIYQIAKKRTRVPPSKRSNG 132
Cdd:cd15325  148 TICQITEEPGYALFSALGSFYLPLAIILVMYCRVYVVALKFSREKKAAKTLG 199
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
1-124 4.67e-29

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 108.17  E-value: 4.67e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFP-PLITIEKESGKEE 79
Cdd:cd15052   70 PLVLCLLWVTLDVLFCTASIMHLCTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVWLISIGISSPiPVLGIIDTTNVLN 149
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 695872405  80 EPKCKINEEKwYIISSCIGSFFAPCVIMVLVY---IRIYQIAKKRTRV 124
Cdd:cd15052  150 NGTCVLFNPN-FVIYGSIVAFFIPLLIMVVTYaltIRLLSNEQKASKV 196
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
1-123 8.79e-29

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 107.73  E-value: 8.79e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITieKESGKEEE 80
Cdd:cd15334   69 GQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMIAVVWIISIFISMPPLFW--RHQTTSRE 146
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 695872405  81 PKCKINEEKW-YIISSCIGSFFAPCVIMVLVYIRIYQIAKKRTR 123
Cdd:cd15334  147 DECIIKHDHIvFTIYSTFGAFYIPLALILILYYKIYRAATRERK 190
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
1-123 2.64e-28

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 106.52  E-value: 2.64e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIeKESGKEEE 80
Cdd:cd15326   69 GRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRHSLQYPTIVTRKRAILALLGVWVLSTVISIGPLLGW-KEPAPPDD 147
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 695872405  81 PKCKINEEKWYIISSCIGSFFAPCVIMVLVYIRIYQIAKKRTR 123
Cdd:cd15326  148 KVCEITEEPFYALFSSLGSFYIPLIVILVMYCRVYIVALKFSR 190
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
1-123 4.02e-28

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 105.76  E-value: 4.02e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIeKESGKEEE 80
Cdd:cd15327   69 GRVFCDIWAAVDVLCCTASILSLCVISVDRYVGVKHSLKYPTIMTERKAGVILVLLWVSSMVISIGPLLGW-KEPPPPDE 147
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 695872405  81 PKCKINEEKWYIISSCIGSFFAPCVIMVLVYIRIYQIAKKRTR 123
Cdd:cd15327  148 SICSITEEPGYALFSSLFSFYLPLMVILVMYFRVYVVALKFSR 190
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
1-142 1.48e-27

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 104.94  E-value: 1.48e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKEEE 80
Cdd:cd15055   69 GDTFCKLHSSLDYILTSASIFNLVLIAIDRYVAVCDPLLYPTKITIRRVKICICLCWFVSALYSSVLLYDNLNQPGLIRY 148
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 695872405  81 PKCK------INeeKWYIISSCIGSFFAPCVIMVLVYIRIYQIAKKRTRVPPSKRSNGEPEKKQNGLA 142
Cdd:cd15055  149 NSCYgecvvvVN--FIWGVVDLVLTFILPCTVMIVLYMRIFVVARSQARAIRSHTAQVSLEGSSKKVS 214
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
1-124 3.29e-27

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 103.55  E-value: 3.29e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKEEE 80
Cdd:cd15049   69 GPLLCDLWLALDYVASNASVMNLLLISFDRYFSVTRPLTYRAKRTPKRAILMIALAWVISFVLWAPAILGWQYFVGERTV 148
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 695872405  81 P--KCKIN--EEKWYIISSCIGSFFAPCVIMVLVYIRIYQIAKKRTRV 124
Cdd:cd15049  149 PdgQCYIQflDDPAITFGTAIAAFYLPVLVMTILYWRIYRETARERKA 196
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
1-121 6.65e-26

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 101.09  E-value: 6.65e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPL-----ITIEKES 75
Cdd:cd15957   69 GNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIqmhwyRATHQEA 148
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 695872405  76 GK--EEEPKCKINEEKWYIISSCIGSFFAPCVIMVLVYIRIYQIAKKR 121
Cdd:cd15957  149 INcyAEETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQ 196
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
4-123 6.30e-25

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 98.54  E-value: 6.30e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   4 WCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPL------------ITI 71
Cdd:cd15320   73 FCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKVAFIMISVAWTLSVLISFIPVqlnwhkakptsfLDL 152
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 695872405  72 EKESGKEEEPKCKINEEKWYIISSCIGSFFAPCVIMVLVYIRIYQIAKKRTR 123
Cdd:cd15320  153 NASLRDLTMDNCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQKQIR 204
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
1-134 7.07e-25

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 98.06  E-value: 7.07e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKEEE 80
Cdd:cd15959   69 GTTVCELWTSVDVLCVTASIETLCAIAVDRYLAITNPLRYEALVTKRRARTAVCLVWAISAAISFLPIMNQWWRDGADEE 148
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 695872405  81 -------PKCK--INEEKWYIISSCIgSFFAPCVIMVLVYIRIYQIAKKRTRVPPSK--RSNGEP 134
Cdd:cd15959  149 aqrcydnPRCCdfVTNMPYAIVSSTV-SFYVPLLVMIFVYVRVFVVATRQVRLIRKDkvRFPPEE 212
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
1-123 2.80e-24

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 96.51  E-value: 2.80e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISF-PPLITIEKESGKE- 78
Cdd:cd15958   69 GSFFCELWTSVDVLCVTASIETLCVIAIDRYLAITSPFRYQSLLTRARAKGIVCTVWAISALVSFlPIMMHWWRDEDDQa 148
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 695872405  79 ----EEPK-CKINEEKWYIISSCIGSFFAPCVIMVLVYIRIYQIAKKRTR 123
Cdd:cd15958  149 lkcyEDPGcCDFVTNRAYAIASSIISFYIPLLIMIFVYLRVYREAKKQIK 198
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
5-131 4.66e-24

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 95.36  E-value: 4.66e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   5 CEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNlkRTPRRIKCI--IFIVWVISAVISFP-PLITIEKESGKEEEP 81
Cdd:cd15305   74 CPIWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHS--RFNSRTKAMmkIAAVWTISIGISMPiPVIGLQDDEKVFVNG 151
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 695872405  82 KCKINEEKWYIISSCIgSFFAPCVIMVLVYIRIYQIAKKRTRVPPSKRSN 131
Cdd:cd15305  152 TCVLNDENFVLIGSFV-AFFIPLIIMVITYCLTIQVLQRQQAINNERRAS 200
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
1-139 1.92e-23

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 93.96  E-value: 1.92e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKEE- 79
Cdd:cd15312   69 GDLFCKIHSSLDMMLSTTSIFHLCFIAVDRYYAVCDPLHYRTKITTPVIKVFLVISWSVPCLFAFGVVFSEVNLEGIEDy 148
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 695872405  80 ------EPKCKINEEK-WYIISSCIGsFFAPCVIMVLVYIRIYQIAKKRTRVPPSKRSNGEPEKKQN 139
Cdd:cd15312  149 valvscTGSCVLIFNKlWGVIASLIA-FFIPGTVMIGIYIKIFFVARKHAKVINNRPSVTKGDSKNK 214
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
1-124 2.96e-23

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 93.46  E-value: 2.96e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISF-----PPLITIEKES 75
Cdd:cd15314   69 GDLFCKIHSSFDITLCTASILNLCFISIDRYYAVCQPLLYRSKITVRVVLVMILISWSVSALVGFgiiflELNIKGIYYN 148
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 695872405  76 GKEEEPKCKINEEKWYIISSCIGSFFAPCVIMVLVYIRIYQIAKKRTRV 124
Cdd:cd15314  149 HVACEGGCLVFFSKVSSVVGSVFSFYIPAVIMLCIYLKIFLVAQRQARS 197
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
1-134 1.09e-22

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 92.37  E-value: 1.09e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKEEE 80
Cdd:cd15048   69 GKVFCKAWLVVDYTLCTASALTIVLISLDRYLSVTKAVKYRAKQTKRRTVLLMALVWILAFLLYGPAIIGWDLWTGYSIV 148
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 695872405  81 P--KCKIN--EEKWYIISSCIGSFFAPCVIMVLVYIRIYQIAKKRTRVPPSKRSNGEP 134
Cdd:cd15048  149 PtgDCEVEffDHFYFTFITSVLEFFIPFISVSFFNLLIYLNIRKRSRRRPLRSVPILP 206
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
5-122 2.46e-22

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 91.05  E-value: 2.46e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   5 CEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFP-PLITIEKESGKEEEPKC 83
Cdd:cd15306   74 CPIWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQASQYNSRATAFIKITVVWLISIGIAIPvPIKGIETDVDNPNNITC 153
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 695872405  84 KINEE--KWYIISSCIGSFFAPCVIMVLVYIRIYQIAKKRT 122
Cdd:cd15306  154 VLTKErfGDFILFGSLAAFFTPLAIMIVTYFLTIHALRKQT 194
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
4-123 1.52e-21

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 89.63  E-value: 1.52e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   4 WCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPL-ITIEKESGKE---- 78
Cdd:cd15319   72 FCDVWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTQRVALVMISVAWTLSVLISFIPVqLNWHKDSGDDwvgl 151
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 695872405  79 --------EEPKCKINEEKWYIISSCIGSFFAPCVIMVLVYIRIYQIAKKRTR 123
Cdd:cd15319  152 hnssisrqVEENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQIQIR 204
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
4-120 7.30e-21

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 86.78  E-value: 7.30e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   4 WCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPL----------ITIEK 73
Cdd:cd15054   72 FCPIWYAFDVMCCSASILNLCVISLDRYLLIISPLRYKLRMTPPRALALILAAWTLAALASFLPIelgwhelgheRTLPN 151
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 695872405  74 ESGKEEEPKCKINEEKWYIISSCIGSFFAPCVIMVLVYIRIYQIAKK 120
Cdd:cd15054  152 LTSGTVEGQCRLLVSLPYALVASCLTFFLPSGAICFTYCRILLAARK 198
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
2-115 1.52e-20

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 85.79  E-value: 1.52e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   2 KVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTP---RRIKCIIFIVWVISAVISFPPLITIEKesgKE 78
Cdd:cd15310   71 RICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQsscRRVSLMITAVWVLAFAVSCPLLFGFNT---TG 147
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 695872405  79 EEPKCKINEEKWYIISSCIgSFFAPCVIMVLVYIRIY 115
Cdd:cd15310  148 DPTVCSISNPDFVIYSSVV-SFYLPFGVTLLVYVRIY 183
7tmA_D2_dopamine_R cd15309
D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
2-123 2.07e-20

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320435 [Multi-domain]  Cd Length: 254  Bit Score: 85.47  E-value: 2.07e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   2 KVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLK-RTPRRIKCIIFIVWVISAVISFPPLITIEKESGKEee 80
Cdd:cd15309   70 RIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRySSKRRVTVMISVVWVLSFAISCPLLFGLNNTDQNE-- 147
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 695872405  81 pkCKINEEKwYIISSCIGSFFAPCVIMVLVYIRIYQIAKKRTR 123
Cdd:cd15309  148 --CIIANPA-FVVYSSIVSFYVPFIVTLLVYVQIYIVLQKEKK 187
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
1-116 4.99e-20

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 84.69  E-value: 4.99e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKEEE 80
Cdd:cd15300   69 GSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPPILCWQYFVGKRTV 148
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 695872405  81 P--KCKIN--EEKWYIISSCIGSFFAPCVIMVLVYIRIYQ 116
Cdd:cd15300  149 PerECQIQflSEPTITFGTAIAAFYIPVSVMTILYCRIYK 188
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
5-111 6.20e-20

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 84.21  E-value: 6.20e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   5 CEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNL--KRTPRRIKciIFIVWVISAVISFP-PLITIEKESGKEEEP 81
Cdd:cd15304   74 CAVWIYLDVLFSTASIMHLCAISLDRYIAIRNPIHHSRfnSRTKAFLK--IIAVWTISVGISMPiPVFGLQDDSKVFKEG 151
                         90       100       110
                 ....*....|....*....|....*....|
gi 695872405  82 KCKINEEKWYIISSCIgSFFAPCVIMVLVY 111
Cdd:cd15304  152 SCLLADENFVLIGSFV-AFFIPLTIMVITY 180
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
1-116 9.10e-20

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 83.86  E-value: 9.10e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKEEE 80
Cdd:cd17790   69 GTVACDLWLALDYVASNASVMNLLIISFDRYFSITRPLTYRAKRTPRRAAIMIGLAWLISFVLWAPAILFWQYLVGERTV 148
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 695872405  81 P--KCKINEEKWYIIS--SCIGSFFAPCVIMVLVYIRIYQ 116
Cdd:cd17790  149 LagQCYIQFLSQPIITfgTAIAAFYLPVTIMIILYWRIYR 188
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
1-123 2.70e-19

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 82.92  E-value: 2.70e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSIT-QAIEYnlKRTPRRIKCIIFIVWVISAVISFPPL------ITIE- 72
Cdd:cd15056   69 GETFCLVRTSLDVLLTTASIMHLCCIALDRYYAICcQPLVY--KMTPLRVAVMLGGCWVIPTFISFLPImqgwnhIGIEd 146
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 695872405  73 --KESGKEEEPKCKINEEKWYIISSCIGSFFAPCVIMVLVYIRIYQIAKKRTR 123
Cdd:cd15056  147 liAFNCASGSTSCVFMVNKPFAIICSTVAFYIPALLMVLAYYRIYVAAREQAH 199
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
1-123 3.14e-19

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 82.88  E-value: 3.14e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKEE- 79
Cdd:cd15317   69 GDLFCKFHTGLDLLLCTTSIFHLCFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIGWLVPGIYTFGLIYTGANDEGLEEy 148
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 695872405  80 ------EPKCKINEEKWYIISSCIgSFFAPCVIMVLVYIRIYQIAKKRTR 123
Cdd:cd15317  149 sseiscVGGCQLLFNKIWVLLDFL-TFFIPCLIMIGLYAKIFLVARRQAR 197
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
13-136 4.04e-19

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 82.30  E-value: 4.04e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405  13 VLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLI-----TIEKESGKEEEPKCKINE 87
Cdd:cd14968   79 LVLTQSSIFSLLAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVGLTPMFgwnngAPLESGCGEGGIQCLFEE 158
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 695872405  88 ---EKWYIISSCIGSFFAPCVIMVLVYIRIYQIAKKRTRVPPSKRSNGEPEK 136
Cdd:cd14968  159 vipMDYMVYFNFFACVLVPLLIMLVIYLRIFRVIRKQLRQIESLLRSRRSRS 210
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
1-126 1.41e-18

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 80.65  E-value: 1.41e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVW------CEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKE 74
Cdd:cd15308   64 GGVWtlspvlCDALMTMDVMLCTASIFNLCAISVDRFIAVSVPLNYNRRQGSVRQLLLISATWILSFAVASPVIFGLNNV 143
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 695872405  75 SGKEEEpKCKInEEKWYIISSCIGSFFAPCVIMVLVYIRIYQ---IAKKRTRVPP 126
Cdd:cd15308  144 PNRDPA-VCKL-EDNNYVVYSSVCSFFIPCPVMLVLYCAMFRglgRERKAMRVLP 196
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
5-123 2.17e-18

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 80.38  E-value: 2.17e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   5 CEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFP-PLITIEKESGKEEEPKC 83
Cdd:cd15307   73 CLTWICLDVLFCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLPlSLMYSKDHASVLVNGTC 152
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 695872405  84 KINEEKWYIISSCIgSFFAPCVIMVLVY-IRIYQIAKKRTR 123
Cdd:cd15307  153 QIPDPVYKLVGSIV-CFYIPLGVMLLTYcLTVRLLARQRSR 192
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
1-128 9.28e-18

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 78.71  E-value: 9.28e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVIsFPPLIT----IEkesG 76
Cdd:cd15301   69 GYEVCDTWLAIDYLASNASVLNLLIISFDRYFSVTRPLTYRARRTTKKAAVMIASAWIISLLL-WPPWIYswpyIE---G 144
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 695872405  77 KEEEPK--CKIN--EEKWYI-ISSCIGSFFAPCVIMVLVYIRIYQIAKKRTRVPPSK 128
Cdd:cd15301  145 KRTVPAgtCYIQflETNPYVtFGTALAAFYVPVTIMCILYWRIWRETKKRQKKQESK 201
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
1-116 1.76e-17

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 78.07  E-value: 1.76e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKEEE 80
Cdd:cd15299   72 GNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTV 151
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 695872405  81 P--KCKIN--EEKWYIISSCIGSFFAPCVIMVLVYIRIYQ 116
Cdd:cd15299  152 PpdECFIQflSEPIITFGTAIAAFYLPVTIMTILYWRIYK 191
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
1-133 3.27e-17

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 77.21  E-value: 3.27e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKEE- 79
Cdd:cd15316   69 GESFCTFHTCCDVSFCYASLFHLCFISVDRYIAVTDPLVYPTKFTVSVSGICISVSWIFSLTYSFSVFYTGVNDDGLEEl 148
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 695872405  80 ------EPKCKIN-EEKWYIISSCigSFFAPCVIMVLVYIRIYQIAKKRTRVPPSKRSNGE 133
Cdd:cd15316  149 vnalncVGGCQIIlNQNWVLVDFL--LFFIPTFAMIILYGKIFLVAKQQARKIEMTSSKAE 207
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
1-123 2.03e-16

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 74.77  E-value: 2.03e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPL---ITIEKESGK 77
Cdd:cd15050   69 GRPVCLFWLSMDYVASTASIFSLFILCIDRYRSVQQPLKYLKYRTKTRASLMISGAWLLSFLWVIPILgwhHFARGGERV 148
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 695872405  78 EEEPKC--KINEEKWYIISSCIGSFFAPCVIMVLVYIRIYqIAKKRTR 123
Cdd:cd15050  149 VLEDKCetDFHDVTWFKVLTAILNFYIPSLLMLWFYAKIF-KAVNRER 195
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
1-123 5.42e-16

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 73.74  E-value: 5.42e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTpRRIKCI-IFIVWVISAVISFPPLITIEKESGKEE 79
Cdd:cd15318   69 GDSFCRLHTCLDTLFCLTSIFHLCFISIDRHCAICDPLLYPSKFT-IRVACIfIAAGWLVPTVYTSVFLYTKAVEEGLAE 147
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405  80 epkckineekWYIISSCIGS----------------FFAPCVIMVLVYIRIYQIAKKRTR 123
Cdd:cd15318  148 ----------LLTSVPCVGScqllynklwgwlnfpvFFIPCLIMIGLYVKIFIVAKRQAR 197
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
1-146 1.32e-15

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 73.12  E-value: 1.32e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKEEE 80
Cdd:cd15337   70 GKVACELYGFAGGIFGFMSITTLAAISIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWLWSLLWSIPPFFGWGRYVPEGFQ 149
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 695872405  81 PKCKI----NEEKWYIISSC--IGSFFAPCVIMVLVYIRIYQIAKKRTRV--PPSKRSNGEPEKKQNGLADQDL 146
Cdd:cd15337  150 TSCTFdylsRDLNNRLFILGlfIFGFLCPLLIIIFCYVNIIRAVRNHEKEmtQTAKSGMGKDTEKNDARKKAEI 223
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
1-138 1.58e-15

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 72.64  E-value: 1.58e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIylaLDVLFCTS---SIVHLCAISLDRYwsitQAIEYNLKR--TPRRIKCIIFIVWVISAVISFPPLITIEKES 75
Cdd:cd15203   69 GSILCKL---VPSLQGVSifvSTLTLTAIAIDRY----QLIVYPTRPrmSKRHALLIIALIWILSLLLSLPLAIFQELSD 141
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 695872405  76 GKEEE-PKCKIN-EEKW--------YIISSCIGSFFAPCVIMVLVYIRIYQIAKKRTRVPPSKRSNGEPEKKQ 138
Cdd:cd15203  142 VPIEIlPYCGYFcTESWpssssrliYTISVLVLQFVIPLLIISFCYFRISLKLRKRVKKKRGKRTLSSRRRRS 214
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
17-122 3.46e-15

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 71.55  E-value: 3.46e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405  17 TSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITieKESGKEEEPKCKINEE---KWYII 93
Cdd:cd14972   82 LASAYSLLAIAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLALLPVLG--WNCVLCDQESCSPLGPglpKSYLV 159
                         90       100
                 ....*....|....*....|....*....
gi 695872405  94 sSCIGSFFAPCVIMVLVYIRIYQIAKKRT 122
Cdd:cd14972  160 -LILVFFFIALVIIVFLYVRIFWCLWRHA 187
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
1-119 1.01e-14

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 70.48  E-value: 1.01e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEY-NLKRTPRRIKCIIFIvWVISAVISFPPLItIEKESGKEE 79
Cdd:cd15104   69 QKVLCLLRMCFVITSCAASVLSLAAIAFDRYLALKQPLRYkQIMTGKSAGALIAGL-WLYSGLIGFLPLI-SPQFQQTSY 146
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 695872405  80 EPKCK----INEEKWYIISSCIgsFFAPCVIMVLVYIRIYQIAK 119
Cdd:cd15104  147 KGKCSffaaFHPRVLLVLSCMV--FFPALLLFVFCYCDILKIAR 188
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
1-123 1.95e-14

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 69.54  E-value: 1.95e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNlKRTPRRIKCIIFIVWVISAVISFPPLITIekeSGKEEE 80
Cdd:cd14969   69 GDPGCVIYGFAVTFLGLVSISTLAALAFERYLVIVRPLKAF-RLSKRRALILIAFIWLYGLFWALPPLFGW---SSYVPE 144
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 695872405  81 PK---CKINeekW---------YIISSCIGSFFAPCVIMVLVYIRIYQIAKKRTR 123
Cdd:cd14969  145 GGgtsCSVD---WyskdpnslsYIVSLFVFCFFLPLAIIIFCYYKIYRTLRKMSK 196
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
1-124 2.84e-14

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 68.84  E-value: 2.84e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKE-- 78
Cdd:cd15297   69 GPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGGRtv 148
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 695872405  79 EEPKCKIN--EEKWYIISSCIGSFFAPCVIMVLVYIRIYQIAKKRTRV 124
Cdd:cd15297  149 PEGECYIQffSNAAVTFGTAIAAFYLPVIIMTVLYWQISRASSREKKV 196
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
1-123 4.85e-14

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 68.51  E-value: 4.85e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKEEE 80
Cdd:cd15083   69 GKTGCDMYGFSGGLFGIMSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLLWVLPPLFGWSRYVLEGLL 148
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 695872405  81 PKCKIN------EEKWYIISSCIGSFFAPCVIMVLVYIRIYQIAKKRTR 123
Cdd:cd15083  149 TSCSFDylsrddANRSYVICLLIFGFVLPLLIIIYCYSFIFRAVRRHEK 197
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
18-114 6.57e-14

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 68.39  E-value: 6.57e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405  18 SSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKEEEPK------CK-----IN 86
Cdd:cd14993   86 ASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAIIIMLPLLVVYELEEIISSEPGtitiyiCTedwpsPE 165
                         90       100
                 ....*....|....*....|....*...
gi 695872405  87 EEKWYIISSCIGSFFAPCVIMVLVYIRI 114
Cdd:cd14993  166 LRKAYNVALFVVLYVLPLLIISVAYSLI 193
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
1-138 9.61e-14

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 67.45  E-value: 9.61e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPL-----ITIEKES 75
Cdd:cd14964   67 PQALCYLIYLLWYGANLASIWTTLVLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWGVSLLLSIPPLvgkgaIPRYNTL 146
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 695872405  76 GKEEEPKCKINEEKWYIissCIGSFFAPCVIMVLVYIRIYQIAKKRTR-VPPSKRSNGEPEKKQ 138
Cdd:cd14964  147 TGSCYLICTTIYLTWGF---LLVSFLLPLVAFLVIFSRIVLRLRRRVRaIRSAASLNTDKNLKA 207
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
1-124 3.21e-13

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 66.20  E-value: 3.21e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKEEE 80
Cdd:cd15298   69 GAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTV 148
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 695872405  81 P--KCKIN--EEKWYIISSCIGSFFAPCVIMVLVYIRIYQIAKKRTRV 124
Cdd:cd15298  149 PdnQCFIQflSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASARERKV 196
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
18-137 7.94e-13

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 64.98  E-value: 7.94e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405  18 SSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKEEEPKC----KINEEKW--Y 91
Cdd:cd14982   86 GSILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVASVPLLLLRSTIAKENNSTTCfeflSEWLASAapI 165
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 695872405  92 IISSCIGSFFAPCVIMVLVYIRIYqiakkRTRVPPSKRSNGEPEKK 137
Cdd:cd14982  166 VLIALVVGFLIPLLIILVCYSLII-----RALRRRSKQSQKSVRKR 206
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
1-129 1.15e-12

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 64.43  E-value: 1.15e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCI-IFIVWVISAVISFPPLITIEKESGKEE 79
Cdd:cd15296   69 GRGLCKLWLVVDYLLCTASVFNIVLISYDRFLSVTRAVSYRAQKGMTRQAVLkMVLVWVLAFLLYGPAIISWEYIAGGSI 148
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 695872405  80 EPKCKINEE---KWY-IISSCIGSFFAPCVIMVLVYIRIY-QIAKKRTRVPPSKR 129
Cdd:cd15296  149 IPEGECYAEffyNWYfLMTASTLEFFTPFISVTYFNLSIYlNIQKRRFRLSRDKK 203
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
1-115 1.67e-12

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 64.33  E-value: 1.67e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYnlKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKEEE 80
Cdd:cd15208   69 GQVLCKIIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMF--KSTAKRARVSILIIWIVSLLIMIPQAIVMECSRVVPLA 146
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 695872405  81 PK------CKineEKW--------YIISSCIGSFFAPCVIMVLVYIRIY 115
Cdd:cd15208  147 NKtilltvCD---ERWsdsiyqkvYHICFFLVTYLLPLCLMILAYFQIF 192
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
1-114 4.39e-12

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 62.77  E-value: 4.39e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEynlKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKEEE 80
Cdd:cd15213   69 GDIFCRISAMLYWFFVLEGVAILLIISVDRYLIIVQRQD---KLNPHRAKILIAVSWVLSFCVSFPPLVGWGKYEFPPRA 145
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 695872405  81 PKCKIN-----EEKWYIISSCIGSFFAPCVIMVLVYIRI 114
Cdd:cd15213  146 PQCVLGytespADRIYVVLLLVAVFFIPFLIMLYSYFCI 184
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
1-136 7.42e-12

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 62.31  E-value: 7.42e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLI---TIEKESGK 77
Cdd:cd14970   68 GEVMCKIVLSVDAYNMFTSIFCLTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVLGLPVIIfarTLQEEGGT 147
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 695872405  78 EEepkCKIN--EEKWY-----IISSCIGSFFAPCVIMVLVYIRIyqIAKKRTRVPPSKRSNGEPEK 136
Cdd:cd14970  148 IS---CNLQwpDPPDYwgrvfTIYTFVLGFAVPLLVITVCYSLI--IRRLRSSRNLSTSGAREKRR 208
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
1-137 1.92e-11

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 61.30  E-value: 1.92e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEyNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKEEE 80
Cdd:cd14999   67 GDVGCRLLFSLDFLTMHASIFTLTVMSTERYLAVVKPLD-TVKRSKSYRKLLAGVIWLLSLLLTLPMAIMIRLVTVEDKS 145
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 695872405  81 PKCKI--------NEEKWYIISSCIGSFFAPCVIMVLVYIRIYQIAKKRTRVPPSKRSNGEPEKK 137
Cdd:cd14999  146 GGSKRiclptwseESYKVYLTLLFSTSIVIPGLVIGYLYIRLARKYWLSQAAASNSSRKRLPKQK 210
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
1-138 2.71e-11

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 60.77  E-value: 2.71e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPL-ITI---EKESG 76
Cdd:cd14997   70 GEFMCKLVPFVELTVAHASVLTILAISFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTSSPVLfITEfkeEDFND 149
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 695872405  77 KEEEPKCKIN-EEKW---YIISSCIGSFFAPCVIMVLVYIRiyqIAKK--RTRVPPSKRSNGEPEKKQ 138
Cdd:cd14997  150 GTPVAVCRTPaDTFWkvaYILSTIVVFFVVPLAILSGLYSV---ICRRlvGHPALESRRADAANRHTL 214
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
1-133 2.93e-11

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 60.63  E-value: 2.93e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESgKEEE 80
Cdd:cd15971   68 GKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRKPRTAKMINMAVWGVSLLVILPIMIYAGVQT-KHGR 146
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 695872405  81 PKCKI----NEEKWY---IISSCIGSFFAPCVIMVLVYIRIyqIAKKRT---RVPPSKRSNGE 133
Cdd:cd15971  147 SSCTIiwpgESSAWYtgfIIYTFILGFFVPLTIICLCYLFI--IIKVKSsgiRVGSSKRKKSE 207
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
7-137 3.02e-11

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 60.72  E-value: 3.02e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   7 IYLALDVLFCT-SSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEK----ESGKEEEP 81
Cdd:cd15068   72 LFIACFVLVLTqSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNcgqpKEGKNHSQ 151
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 695872405  82 KCK------INEEKWYIISSCIGSFFA----PCVIMVLVYIRIY-----QIAKKRTRVPPSKRSNGEPEKK 137
Cdd:cd15068  152 GCGegqvacLFEDVVPMNYMVYFNFFAcvlvPLLLMLGVYLRIFlaarrQLKQMESQPLPGERARSTLQKE 222
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
1-120 3.10e-11

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 60.53  E-value: 3.10e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKEE- 79
Cdd:cd15302   70 GWVLCDLWLSVDYTVCLVSIYTVLLITIDRYCSVKIPAKYRNWRTPRKVLLIIAITWIIPALLFFISIFGWQYFTGQGRs 149
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 695872405  80 --EPKCKIN--EEKWYIISSCIGSFFAPCVIMVLVYIRIYQIAKK 120
Cdd:cd15302  150 lpEGECYVQfmTDPYFNMGMYIGYYWTTLIVMLILYAGIYRAANR 194
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
1-133 7.01e-11

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 59.78  E-value: 7.01e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKEEE 80
Cdd:cd15093   68 GSVLCRLVLSVDGINMFTSIFCLTVMSVDRYLAVVHPIKSARWRRPRVAKVVNLAVWVASLLVILPVVVFAGTRENQDGS 147
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 695872405  81 PKCKIN----EEKWY---IISSCIGSFFAPCVIMVLVYIRIyqIAKKRT---RVPPSKRSNGE 133
Cdd:cd15093  148 SACNMQwpepAAAWSagfIIYTFVLGFLLPLLIICLCYLLI--VIKVKSaglRAGWQQRKRSE 208
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
1-114 7.60e-11

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 59.54  E-value: 7.60e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLI--TIEKESGke 78
Cdd:cd14984   67 GSFLCKLVSALYTINFYSGILFLACISIDRYLAIVHAVSALRARTLLHGKLTCLGVWALALLLSLPEFIfsQVSEENG-- 144
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 695872405  79 eEPKCKIN-----EEKWYIISS----CIGsFFAPCVIMVLVYIRI 114
Cdd:cd14984  145 -SSICSYDypedtATTWKTLLRllqnILG-FLLPLLVMLFCYSRI 187
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
17-131 9.86e-11

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 59.18  E-value: 9.86e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405  17 TSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPP-----LITIEKESGKEEEPKCKINE---- 87
Cdd:cd14978   89 TASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRffeyeVVECENCNNNSYYYVIPTLLrqne 168
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 695872405  88 ---EKWYIISSCIGSFFAPCVIMVLVYIRI---YQIAKKRTRVPPSKRSN 131
Cdd:cd14978  169 tylLKYYFWLYAIFVVLLPFILLLILNILLiraLRKSKKRRRLLRRRRRL 218
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
1-123 1.24e-10

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 58.68  E-value: 1.24e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTP-RRIKCIIFIVWVISAVISFPPLITIEKESGKEE 79
Cdd:cd15295   69 GRGLCVFWLVIDYLLCTASVYNIVLISYDRYQSVSNAVSYRNQQTAtLRIVTQMVAVWVLAFLVHGPAILVSDSWKTEDG 148
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 695872405  80 EPKCKINEEKWYIISSCIGSFFAPCVIMVLVYIRIYQIAKKRTR 123
Cdd:cd15295  149 ECEPEFFSNWYILAITSVLEFLVPVILVAYFNTQIYWSLWKRLR 192
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
1-114 2.11e-10

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 58.46  E-value: 2.11e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYwsitQAIEYNLKR--TPRRIKCIIFIVWVISAVISFPPLI--TIEKES- 75
Cdd:cd15390   69 GLFYCKFSNFVAITTVAASVFTLMAISIDRY----IAIVHPLRPrlSRRTTKIAIAVIWLASFLLALPQLLysTTETYYy 144
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 695872405  76 -GKEEEPKCKI--------NEEKWYIISSCIGSFFAPCVIMVLVYIRI 114
Cdd:cd15390  145 yTGSERTVCFIawpdgpnsLQDFVYNIVLFVVTYFLPLIIMAVAYTRV 192
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
1-120 3.52e-10

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 57.67  E-value: 3.52e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIvWVISAVISFPPLITIekeSGKEEE 80
Cdd:cd15074   69 GDIGCVFYGFCGFLFGCCSINTLTAISIYRYLKICHPPYGPKLSRRHVCIVIVAI-WLYALFWAVAPLVGW---GSYGPE 144
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 695872405  81 P---KCKINEEKW--------YIISSCIGSFFAPCVIMVLVYIRIYQIAKK 120
Cdd:cd15074  145 PfgtSCSIDWTGAsasvggmsYIISIFIFCYLLPVLIIVFSYVKIIRKVKS 195
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
5-120 3.70e-10

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 57.55  E-value: 3.70e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   5 CEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKEEEPKCK 84
Cdd:cd15215   72 CTALVVLMHLFAFAGVNTIVVVSVDRYLAIIHPLSYPTKMTPRRGYLLIYGTWIVSVLQSTPPLYGWGQAAFDERNALCS 151
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 695872405  85 I--NEEKWYIISSCIGSFFAPCVIMVLVYIRIYQIAKK 120
Cdd:cd15215  152 ViwGSSYSYTILSVVSSFVLPVIIMLACYSMVFRAARR 189
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
1-137 7.26e-10

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 56.60  E-value: 7.26e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYwsitQAIEYNLKR--TPRRIKCIIFIVWVISAVISFPPLIT---IEKES 75
Cdd:cd15392   70 GEFMCPVVNYLQAVSVFVSAFTLVAISIDRY----VAIMWPLRPrmTKRQALLLIAVIWIFALATALPIAITsrlFEDSN 145
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405  76 GKEEEPKCkinEEKW------YIISSC--IGSFFAPCVIMVLVYIRIyqiakkrTRVPPSKRSNGEPEKK 137
Cdd:cd15392  146 ASCGQYIC---TESWpsdtnrYIYSLVlmILQYFVPLAVLVFTYTRI-------GIVVWAKRTPGEAENN 205
7tmA_GPR45 cd15403
G protein-coupled receptor 45, member of the class A family of seven-transmembrane G ...
1-122 7.66e-10

G protein-coupled receptor 45, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR45 and closely related proteins found in vertebrates. GPR45 is also called PSP24 in Xenopus and PSP24-alpha (or PSP24-1) in mammals. GPR45 shows the highest sequence homology with GPR63 (PSP24-beta, or PSP24-2). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320525 [Multi-domain]  Cd Length: 301  Bit Score: 56.78  E-value: 7.66e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEynlKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKEEE 80
Cdd:cd15403   69 GAHFCRISAMLYWFFVLEGVAILLIISVDRFLIIVQRQD---KLNPHRAKVMIAISWVLSFCISFPSVVGWTLVEVPARA 145
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 695872405  81 PKC-----KINEEKWYIISSCIGSFFAPCVIMVLVYIRIYQIAKKRT 122
Cdd:cd15403  146 PQCvlgytESPADRVYAVLLVVAVFFVPFSIMLYSYLCILNTVRRNA 192
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
1-123 8.70e-10

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 56.62  E-value: 8.70e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYwsitQAIEYNLKRT--PRRIKCIIFIVWVISAVISFPPLITIEKESGKE 78
Cdd:cd14986   69 GDVLCRIVKYLQVVGLFASTYILVSMSLDRY----QAIVKPMSSLkpRKRARLMIVVAWVLSFLFSIPQLVIFVERELGD 144
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 695872405  79 EEPKCK---INEEKW--YIISSCIGSFFAPCVIMVLVYIRIYQIAKKRTR 123
Cdd:cd14986  145 GVHQCWssfYTPWQRkvYITWLATYVFVIPLIILSYCYGRILRTIWIRSR 194
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
1-114 2.74e-09

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 55.13  E-value: 2.74e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPL-----ITIEKES 75
Cdd:cd14992   69 GHFLCKIVNYLRTVSVYASSLTLTAIAFDRYFAIIHPLKPRHRQSYTTTVIIIITIWVVSLLLAIPQLyyattEVLFSVK 148
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 695872405  76 GKEEEPKCKINE------EKWYIISSCIGSFFAPCVIMVLVYIRI 114
Cdd:cd14992  149 NQEKIFCCQIPPvdnktyEKVYFLLIFVVIFVLPLIVMTLAYARI 193
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
1-130 3.04e-09

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 55.13  E-value: 3.04e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCiiFIVWVISAVISFPPLI--TIEKESGKE 78
Cdd:cd15176   67 GTAMCKITSALYTMNFSCGMQFLACISVDRYVAITKATSRQFTGKHCWIVC--LCVWLLAILLSIPDLVfsTVRENSDRY 144
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 695872405  79 E----EPKCKINEEKWYI-ISSCIGSFFAPCVIMVLVYIRiyqIAKKRTRVPPSKRS 130
Cdd:cd15176  145 RclpvFPPSLVTSAKATIqILEVLLGFVLPFLVMVFCYSR---VARALSRTPNVKKS 198
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
1-114 3.25e-09

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 54.76  E-value: 3.25e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLI---TIE---KE 74
Cdd:cd15012   68 GEVLCRMYQFVHSLSYTASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNTPYFVfsqTVEilvTQ 147
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 695872405  75 SGKEEEPKCKI---NEEKWYIISSCIGSFFAPCVIMVLVYIRI 114
Cdd:cd15012  148 DGQEEEICVLDremFNSKLYDTINFIVWYLIPLLIMTVLYSKI 190
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
18-116 3.40e-09

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 54.70  E-value: 3.40e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405  18 SSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKEEEPKC--KINEEKWYI--- 92
Cdd:cd15160   86 ASIGFLCCIAVDRYLAVVHPLRFRGLRTRRFALKVSASIWVLELGTHSVFLGHDELFRDEPNHTLCyeKYPMEGWQAsyn 165
                         90       100
                 ....*....|....*....|....*
gi 695872405  93 -ISSCIGsFFAPCVIMVLVYIRIYQ 116
Cdd:cd15160  166 yARFLVG-FLIPLSLILFFYRRVLR 189
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
1-129 4.08e-09

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 54.71  E-value: 4.08e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRtpRRIKCIIFIVWVISAVISFPPLITIEKESGKEEE 80
Cdd:cd15195   69 GDLMCRVMMFLKQFGMYLSSFMLVVIALDRVFAILSPLSANQAR--KRVKIMLTVAWVLSALCSIPQSFIFSVLRKMPEQ 146
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 695872405  81 P---KC---KINEEKW----YIISSCIGSFFAPCVIMVLVYIRI-YQIAK--KRTRVPPSKR 129
Cdd:cd15195  147 PgfhQCvdfGSAPTKKqerlYYFFTMILSFVIPLIITVTCYLLIlFEISKmaKRARDTPISN 208
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
1-133 4.49e-09

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 54.42  E-value: 4.49e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKEsgkEEE 80
Cdd:cd15974   68 GSFLCRLVMTVDGVNQFTSIFCLTVMSIDRYLAVVHPIKSTKWRRPRVAKLINATVWTLSFLVVLPVIIFSDVQ---PDL 144
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 695872405  81 PKCKINEEK----W---YIISSCIGSFFAPCVIMVLVYIRIY-QIAKKRTRVPPSKRSNGE 133
Cdd:cd15974  145 NTCNISWPEpvsvWstaFIIYTAVLGFFGPLLVICLCYLLIViKVKSSGLRVGSTKRRKSE 205
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
1-133 8.39e-09

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 53.65  E-value: 8.39e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKEee 80
Cdd:cd15972   68 GSFMCRLVMTVDAINQFTSIFCLTVMSVDRYLAVVHPIRSSKWRKPPVAKTVNATVWALSFLVVLPVVIFSGVPGGMG-- 145
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 695872405  81 pKCKIN----EEKW---YIISSCIGSFFAPCVIMVLVYIRIY---QIAKKRTRVPPSKRSNGE 133
Cdd:cd15972  146 -TCHIAwpepAQVWragFIIYTATLGFFCPLLVICLCYLLIVvkvRSSGRRVRATSTKRRGSE 207
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
1-139 8.52e-09

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 53.84  E-value: 8.52e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLIT-IEKESGKEE 79
Cdd:cd15096   69 GDVWCKIVQYLVYVTAYASVYTLVLMSLDRYLAVVHPITSMSIRTERNTLIAIVGIWIVILVANIPVLFLhGVVSYGFSS 148
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 695872405  80 EPK--CKINEEKWYIISSCIGSFF-----APCVIMVLVYIRIyqIAKKRTRVPPSKRSNGEPEKKQN 139
Cdd:cd15096  149 EAYsyCTFLTEVGTAAQTFFTSFFlfsylIPLTLICVLYMLM--LRRLRRQKSPGGRRSAESQRGKR 213
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
5-114 1.11e-08

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 53.51  E-value: 1.11e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   5 CEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKES-------GK 77
Cdd:cd14979   74 CKLYYFLFEACTYATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAIPILFLMGIQYlngplpgPV 153
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 695872405  78 EEEPKCKI---NEEKWYIISSCIGSFFA-PCVIMVLVYIRI 114
Cdd:cd14979  154 PDSAVCTLvvdRSTFKYVFQVSTFIFFVlPMFVISILYFRI 194
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
1-68 1.24e-08

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 53.18  E-value: 1.24e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPL 68
Cdd:cd15336   69 GEKGCELYAFCGALFGITSMITLLAISLDRYLVITKPLASIRWVSKKRAMIIILLVWLYSLAWSLPPL 136
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
1-128 1.45e-08

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 52.86  E-value: 1.45e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKEEE 80
Cdd:cd15120   68 GTVLCKVLNSTLSVGMFTSVFLLTAISLDRYLLTLHPVWSRQHRTNRWASAIVLGVWISAILLSIPYLAFRETRLDEKGK 147
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405  81 PKCKINeekwYIISS-----------------CIGS-----FFAPCVIMVLVYIRIYQIAKKRTRVPPSK 128
Cdd:cd15120  148 TICQNN----YALSTnwesaevqasrqwihvaMFVFrfllgFLLPFLIITFCYVRMALKMKERGLARSSK 213
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
5-132 1.78e-08

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 52.59  E-value: 1.78e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   5 CEIYLALDVLFCTSSIVHLCAISLDRYWSITqaieYNLKR---TPRRIKCIIFIVWVISAVISFPPL------------- 68
Cdd:cd15137   80 CTFAGFLATLSSEVSVLILTLITLDRFICIV----FPFSGrrlGLRRAIIVLACIWLIGLLLAVLPLlpwdyfgnfygrs 155
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 695872405  69 -------ITIEKESGKEeepkckineekwYIISSCIGSFFAPCVIMVLVYIRIYqIAKKRTRVPPSKRSNG 132
Cdd:cd15137  156 gvclplhITDERPAGWE------------YSVFVFLGLNFLAFVFILLSYIAMF-ISIRRTRKAAASRKSK 213
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
1-141 1.86e-08

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 52.84  E-value: 1.86e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKEEE 80
Cdd:cd15088   69 GEVMCKIITALDANNQFTSTYILTAMSVDRYLAVVHPIRSTKYRTRFVAKLVNVGLWAASFLSILPVWVYSSLIYFPDGT 148
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 695872405  81 PKCKIN-----EEKWYIISSCIGSFFAPCVIMVLVYIRIyqIAKKRTRVPPSKRSNGEPEKKQNGL 141
Cdd:cd15088  149 TFCYVSlpspdDLYWFTIYHFILGFAVPLVVITVCYILI--LHRLARGVAPGNQSHGSSRTKRVTK 212
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
1-68 1.90e-08

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 52.58  E-value: 1.90e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNlKRTPRRIKCIIFIVWVISAVISFPPL 68
Cdd:cd15079   68 GPLGCQIYAFLGSLSGIGSIWTNAAIAYDRYNVIVKPLNGN-PLTRGKALLLILFIWLYALPWALLPL 134
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
18-129 1.99e-08

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 52.69  E-value: 1.99e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405  18 SSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLI---TIEKESGKEEEPKCKIN------EE 88
Cdd:cd14974   85 ASVFLLTAISLDRCLLVLHPVWAQNHRTVRLASVVCVGIWILALVLSVPYFVfrdTVTHHNGRSCNLTCVEDydlrrsRH 164
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 695872405  89 KWYIISSCIGSFFAPCVIMVLVYIRIYqIAKKRTRVPPSKR 129
Cdd:cd14974  165 KALTVIRFLCGFLLPLLIIAICYSVIA-VKLRRKRLAKSSK 204
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
1-126 2.93e-08

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 52.46  E-value: 2.93e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKEEE 80
Cdd:cd15005   70 GALSCKVIAFLAVLFCFHSAFTLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAWTLSVAMAFPPVFDVGTYTFIREE 149
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 695872405  81 PKCkINEEKWYIISSCIGSFFAPCVIMV---LVYIRIYQIAKKRTRVPP 126
Cdd:cd15005  150 DQC-TFEHRSYKANDTLGFMLVLAVVIAathLVYLKLLIFLRHHRKMKP 197
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
1-135 3.20e-08

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 51.93  E-value: 3.20e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDV--LFCTSSIvhLCAISLDRYWSITQAIeyNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESgke 78
Cdd:cd15382   70 GDFLCRLMLFFRAfgLYLSSFV--LVCISLDRYFAILKPL--RLSDARRRGRIMLAVAWVISFLCSIPQSFIFHVES--- 142
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 695872405  79 eEPK------CKI-------NEEKWYIISSCIGSFFAPCVIMVLVYIRI-YQIAKKRTRVPPSKRSNGEPE 135
Cdd:cd15382  143 -HPCvtwfsqCVTfnffpshDHELAYNIFNMITMYALPLIIIVFCYSLIlCEISRKSKEKKEDVSEKSSSV 212
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
18-124 4.64e-08

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 51.59  E-value: 4.64e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405  18 SSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKEEEPKCKINEEKWYIISSCI 97
Cdd:cd15182   84 SSILFLTLMTIDRYLAVVHPLSALRSRKLRYASLVSVAVWVISILASLPELILSTVMKSDEDGSLCEYSSIKWKLGYYYQ 163
                         90       100       110
                 ....*....|....*....|....*....|
gi 695872405  98 GS--FFAPCVIMVLVYIRIYQ-IAKKRTRV 124
Cdd:cd15182  164 QNlfFLIPLGIIVYCYVRILQtLMRTRTMR 193
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
1-130 6.90e-08

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 50.97  E-value: 6.90e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVL--FCTSSIVhlCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKE 78
Cdd:cd15339   68 GSPLCTIITSLDTCnqFACSAIM--TAMSLDRYIALVHPFRLTSLRTRSKTIRINLLVWAASFILVLPVWVYAKVIKFRD 145
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 695872405  79 EEPKCKIN-----EEKWYIISSCIGSFFAP------CVIMVLVYI-RIYQIAKKRTRVPPSKRS 130
Cdd:cd15339  146 GLESCAFNltspdDVLWYTLYQTITTFFFPlpliliCYILILCYTwEMYRKNKKAGRYNTSIPR 209
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
23-114 1.15e-07

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 50.36  E-value: 1.15e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405  23 LCAISLDRYWSIT---QAIEYnlkRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKEEEPK--CK-----INEEKWYI 92
Cdd:cd15095   91 LTALSVDRYYAIVhpiRSLRF---RTPRVAVVVSACIWIVSFLLSIPVAIYYRLEEGYWYGPQtyCRevwpsKAFQKAYM 167
                         90       100
                 ....*....|....*....|..
gi 695872405  93 ISSCIGSFFAPCVIMVLVYIRI 114
Cdd:cd15095  168 IYTVLLTYVIPLAIIAVCYGLI 189
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
1-122 1.26e-07

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 50.21  E-value: 1.26e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITqaieYNLKR--TPRRIKCIIFIVWVISAVISFPPL-ITIEKESGK 77
Cdd:cd15391   69 PAPMCPIVLYVQLVSVTASVLTNTAIGIDRFFAVI----FPLRSrhTKSRTKCIIASIWAISFSLSSVQLfAGRTQRYGQ 144
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 695872405  78 EEEPKcKINEEKW---------YIISSCIGSFFAPCVIMVLVYIRIYQIAKKRT 122
Cdd:cd15391  145 YSEGR-VLCGESWpgpdtsrsaYTVFVMLLTYIIPLLILTSTYGYVGFRLWNRT 197
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
1-123 1.35e-07

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 50.19  E-value: 1.35e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLI--TIEKESGKE 78
Cdd:cd14976   71 GTAMCKVVRYVTKLNMYSSIFFLTALSVTRYIAVARALKHGWIRKAFGAFATTIAIWAAAALAAIPEAIfsTDTWSSVNH 150
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 695872405  79 EE-----PKcKINEEKW------YIISSCIGSFFAPCVIMVLVYIRI-YQIAKKRTR 123
Cdd:cd14976  151 TLcllrfPK-NSSVTRWynwlgmYQLQKVVLGFFLPLGIITLSYLLLlRFLQRKRGG 206
7tmA_SREB3_GPR173 cd15217
super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...
5-126 1.42e-07

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320345 [Multi-domain]  Cd Length: 329  Bit Score: 50.33  E-value: 1.42e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   5 CEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKEEEPKCk 84
Cdd:cd15217   74 CKIVAFMAVLFCFHAAFMLFCISVTRYMAIAHHRFYSKRMTFWTCIAVICMVWTLSVAMAFPPVFDVGTYKFIREEDQC- 152
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 695872405  85 INEEKWYIISSCIGSFFAPCVIMV---LVYIRIYQIAKKRTRVPP 126
Cdd:cd15217  153 IFEHRYFKANDTLGFMLMLAVLIVathIVYGKLLLFEYRHRKMKP 197
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
1-111 1.62e-07

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 49.95  E-value: 1.62e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKEEE 80
Cdd:cd15089   68 GELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLSSGVGVPIMVMAVTKTPRDGA 147
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 695872405  81 PKC--KINEEKWY---IISSC--IGSFFAPCVIMVLVY 111
Cdd:cd15089  148 VVCmlQFPSPSWYwdtVTKICvfIFAFVVPILVITVCY 185
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
18-130 1.76e-07

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 50.16  E-value: 1.76e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405  18 SSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKEEEPKCKINEEK------WY 91
Cdd:PHA03087 124 NSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYTTKKDHETLICCMFYNNKtmnwklFI 203
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 695872405  92 IISSCIGSFFAPCVIMVLVYIRIYQIAKKRTRVPPSKRS 130
Cdd:PHA03087 204 NFEINIIGMLIPLTILLYCYSKILITLKGINKSKKNKKA 242
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
14-130 2.01e-07

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 49.75  E-value: 2.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405  14 LFCTSSIvhLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKE-EEPKCK-----INE 87
Cdd:cd15181   82 FYCSSLL--LACISVDRYLAIVHAIHSYRHRRLRSVHLTCGSIWLVCFLLSLPNLVFLEVETSTNaNRTSCSfhqygIHE 159
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 695872405  88 EKWYIISSC---IGSFFAPCVIMVLVYIRIYQIAKKRTRVPPSKRS 130
Cdd:cd15181  160 SNWWLTSRFlyhVVGFFLPLLIMGYCYATIVVTLCQSSRRLQKQKA 205
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
7-121 2.08e-07

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 49.93  E-value: 2.08e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   7 IYLALDVLFCT-SSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLI-----------TIEKE 74
Cdd:cd15069   72 LFLACFVLVLTqSSIFSLLAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLAFGIGLTPFLgwnkamsatnnSTNPA 151
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 695872405  75 SGKEEEPKCKIN-------EEKWYIISSCIGSFFAPCVIMVLVYIRIYQIAKKR 121
Cdd:cd15069  152 DHGTNHSCCLISclfenvvPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQ 205
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
5-124 2.32e-07

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 49.55  E-value: 2.32e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   5 CEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNlKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKEEEPK-- 82
Cdd:cd14980   81 CLLACFLVSLSSLMSVLMMLLITLDRYICIVYPFSNK-RLSYKSAKIILILGWLFSIIFAAIPILYSINQPGDNRLYGys 159
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 695872405  83 --C-----KINEEKWYIISSC---IGSFFAPCVIMVLVYIRIYQIAKKRTRV 124
Cdd:cd14980  160 siCmpsnvSNPYYRGWLIAYLlltFIAWIIICILYILIFISVRKSRKSARRS 211
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
8-138 2.33e-07

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 49.73  E-value: 2.33e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   8 YLALDVLFCTSSIvhLCAISLDRYWSITQAIeyNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKEEEPKCKIN- 86
Cdd:cd15197   78 YLQVVVTYASTYV--LVALSIDRYDAICHPM--NFSQSGRQARVLICVAWILSALFSIPMLIIFEKTGLSNGEVQCWILw 153
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 695872405  87 EEKWYIIS--SCIGS--FFAPCVIMVLVYIRIYQIAKKRTRVPPSKRSNGEPEKKQ 138
Cdd:cd15197  154 PEPWYWKVymTIVAFlvFFIPATIISICYIIIVRTIWKKSKIQVTINKAGLHDGSS 209
7tmA_CCR7 cd15175
CC chemokine receptor type 7, member of the class A family of seven-transmembrane G ...
18-114 2.57e-07

CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR7 is a major homeostatic receptor responsible for lymph node development and effective adaptive immune responses and plays a critical role in trafficking of dendritic cells and B and T lymphocytes. Its only two ligands, CCL and CCl21, are primarily produced by stromal cells in the T cell zones of lymph nodes and spleen. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341331 [Multi-domain]  Cd Length: 278  Bit Score: 49.38  E-value: 2.57e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405  18 SSIVHLCAISLDRYWSITQAIEYNLKRtPRRI---KCIIFIVWVISAVISFPPLItIEKESGKEEEPKCKINEE---KWY 91
Cdd:cd15175   84 SGMLLLMCISIDRYFAIVQAASAHRHR-SRAVfisKVSSLGVWVLAFILSIPELL-YSGVNNNDGNGTCSIFTNnkqTLS 161
                         90       100
                 ....*....|....*....|....*.
gi 695872405  92 I---ISSCIGSFFAPCVIMVLVYIRI 114
Cdd:cd15175  162 VkiqISQMVLGFLVPLVVMSFCYSVI 187
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
1-121 3.19e-07

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 49.08  E-value: 3.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKEEE 80
Cdd:cd15973   68 GSAMCRTVLSVDGINMFTSVFCLTVLSVDRYIAVVHPLRAARYRRPTVAKMINICVWILSLLVISPIIIFADTATRKGQA 147
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 695872405  81 PKCKI--NEEKW---YIISSCIGSFFAPCVIMVLVYIRIyqIAKKR 121
Cdd:cd15973  148 VACNLiwPHPAWsaaFVIYTFLLGFLLPVLAIGLCYILI--IGKMR 191
7tmA_GPR55-like cd15165
G protein-coupled receptor 55 and similar proteins, member of the class A family of ...
19-131 4.04e-07

G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR55 shares closest homology with GPR35, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Lysophosphatidylinositol (LPI) is currently considered as the endogenous ligand for GPR55, although the receptor was initially de-orphanized as a cannabinoid receptor and binds many cannabinoid ligands.


Pssm-ID: 320293 [Multi-domain]  Cd Length: 277  Bit Score: 48.87  E-value: 4.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405  19 SIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPpliTIEKESGKEEEPKC--KINEEKW---YII 93
Cdd:cd15165   85 SILIIVCISVDRYIAIRHPFLAKRLRSPRKAAIVCLTIWVFVWAGSIP---IYSFHDKPTNNTRCfhGFSNKTWskkVIV 161
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 695872405  94 SSCIGSFFAPCVIMVLVYIRIYQIAKKRTRVPPSKRSN 131
Cdd:cd15165  162 VVEEFGFLIPMAVMVFCSVQIIRTLLDMRRPEQPKVKQ 199
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
1-127 4.08e-07

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 48.96  E-value: 4.08e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQaIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKEEE 80
Cdd:cd15073   69 GYAGCQWYAFLNIFFGMASIGLLTVVAVDRYLTICR-PDLGRKMTTNTYTVMILLAWTNAFFWAAMPLVGWASYALDPTG 147
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 695872405  81 PKCKINEEK------WYIISSCIGSFFAPCVIMVLVYIRIYQIAKKRT--RVPPS 127
Cdd:cd15073  148 ATCTINWRKndssfvSYTMSVIVVNFIVPLAVMFYCYYNVSRFVKKVLasDCLES 202
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
11-131 4.28e-07

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 48.64  E-value: 4.28e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405  11 LDVLFCTS---SIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFppLITIEKESGkeeepkckine 87
Cdd:cd15103   82 IDSMICSSllaSICSLLAIAVDRYITIFYALRYHSIMTVRRAGVIITAIWVFCTVCGI--LFIIYSDSV----------- 148
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 695872405  88 ekwYIISSCIGSFFAPCVIMVLVYIRIYQIAKKRTR--------VPPSKRSN 131
Cdd:cd15103  149 ---PVIICLISMFFAMLVLMASLYVHMFLLARSHVKkiaalpgqRSTRQRAN 197
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
1-121 4.49e-07

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 48.72  E-value: 4.49e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLI-TIEKESGKEE 79
Cdd:cd15925   70 GGAMCKMVLTATVLNVYASVFLLTAMSVTRYWVVASAAGPGTHLSTFWAKIITLALWAAALLATVPTAIfATEGEVCGVE 149
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 695872405  80 EPKCKINEEKW---YIISSCIGSFFAPCVIMVLVYIRIYQIAKKR 121
Cdd:cd15925  150 LCLLKFPSNYWlgaYHLQRVVVAFVVPLGVITTSYLLLLSFLQQH 194
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
1-121 4.52e-07

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 48.75  E-value: 4.52e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKEEE 80
Cdd:cd15970   68 GSLLCRLVLSVDAINMFTSIYCLTVLSIDRYIAVVHPIKAARYRRPTVAKMVNLGVWVFSILVILPIIIFSNTAPNSDGS 147
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 695872405  81 PKCKIN----EEKW---YIISSCIGSFFAPCVIMVLVYIRIyqIAKKR 121
Cdd:cd15970  148 VACNMQmpepSQRWlavFVVYTFLMGFLLPVIAICLCYILI--IVKMR 193
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
1-119 4.88e-07

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 48.40  E-value: 4.88e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKEEE 80
Cdd:cd15214   68 GVVWCNFSALLYLLISSASMLTLGAIAIDRYYAVLYPMVYPMKITGNRAVLALVYIWLHSLIGCLPPLFGWSSLEFDRFK 147
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 695872405  81 PKCKI--NEEKWYIISSCIGSFFAPCVIMVLVYIRIYQIAK 119
Cdd:cd15214  148 WMCVAawHKEAGYTAFWQVWCALLPFVVMLVCYGFIFRVAR 188
7tmA_CCR9 cd15174
CC chemokine receptor type 9, member of the class A family of seven-transmembrane G ...
18-114 8.63e-07

CC chemokine receptor type 9, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR9 is a homeostatic receptor specific for CCL25 (formerly known as thymus expressed chemokine) and is highly expressed on both immature and mature thymocytes as well as on intestinal homing T Lymphocytes and mucosal Lymphocytes. In cutaneous melanoma, activation of CCR9-CCL25 has been shown to stimulate metastasis to the small intestine. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 320302 [Multi-domain]  Cd Length: 280  Bit Score: 47.82  E-value: 8.63e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405  18 SSIVHLCAISLDRYWSITQAIEYNLKRTPR--RIKCIIFIVWVISAVISFPPLITiekESGKEEEPK--CK----INEEK 89
Cdd:cd15174   84 SCMLLLTCISVDRYIAIVQATKAHNSKNKRllYSKLVCFFVWLLSTILSLPEILF---SQSKEEESVttCTmvypSNESN 160
                         90       100       110
                 ....*....|....*....|....*....|
gi 695872405  90 WYIISS-----CIGsFFAPCVIMVLVYIRI 114
Cdd:cd15174  161 RFKVAVlalkvTVG-FFLPFVVMVICYTLI 189
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
1-111 8.96e-07

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 47.68  E-value: 8.96e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLI--TIEKESGKE 78
Cdd:cd15090   68 GNILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFmaTTKYRQGSI 147
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 695872405  79 EepkCKI--NEEKWY---IISSC--IGSFFAPCVIMVLVY 111
Cdd:cd15090  148 D---CTLtfSHPSWYwenLLKICvfIFAFIMPVLIITVCY 184
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
1-114 9.60e-07

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 47.66  E-value: 9.60e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWsitqAIEYNLK----RTPRRIKCIIFIVWVISAVISFPPL-ITIEKES 75
Cdd:cd15001   68 GAFLCKAVAYLQLLSFICSVLTLTAISIERYY----VILHPMKaksfCTIGRARKVALLIWILSAILASPVLfGQGLVRY 143
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 695872405  76 GKEEEPKCKINEEKW--------YIISSCIGSFFAPCVIMVLVYIRI 114
Cdd:cd15001  144 ESENGVTVYHCQKAWpstlysrlYVVYLAIVIFFIPLIVMTFAYARD 190
7tmA_SREB2_GPR85 cd15218
super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of ...
1-126 1.12e-06

super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320346 [Multi-domain]  Cd Length: 330  Bit Score: 47.72  E-value: 1.12e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKEEE 80
Cdd:cd15218   70 GTLTCKVIAFLGVLSCFHTAFMLFCISVTRYLAIAHHRFYTKRLTFWTCLAVICMVWTLSVAMAFPPVLDVGTYSFIREE 149
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 695872405  81 PKCKInEEKWYIISSCIGSFFAPCVIMV---LVYIRIYQIAKKRTRVPP 126
Cdd:cd15218  150 DQCTF-QHRSFRANDSLGFMLLLALILLatqLVYLKLIFFVHDRRKMKP 197
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
18-138 1.12e-06

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 47.47  E-value: 1.12e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405  18 SSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVIsaVISFPPLITIEKESGKEE--EPKC--KINEEKWY-- 91
Cdd:cd15365   86 TSTALLTCIALDRYLAVVHPLKFMHLRTIRTALSVSVAIWLL--EICFNAVILTWEDSFHESssHTLCydKFPLEDWQar 163
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 695872405  92 --IISSCIGsFFAPCVIMVLVYIRIYQIAKkrtrvppSKRSNGEPEKKQ 138
Cdd:cd15365  164 lnLFRICLG-YLLPLLIILFCYWKIYQAVR-------SNQATEDQEKKK 204
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
1-139 1.33e-06

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 47.17  E-value: 1.33e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESgKEEE 80
Cdd:cd15092   68 GNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIKALDVRTPHKAKVVNVCIWALASVVGVPVMVMGSAQV-EDEE 146
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 695872405  81 PKCKIN----EEKW-YIISSCIgsFFAPCVIMVLVYIRIYQIAKKRTRvpPSKRSNGEPEKKQN 139
Cdd:cd15092  147 IECLVEiptpQDYWdPVFGICV--FLFSFIIPVLIISVCYSLMIRRLR--GVRLLSGSKEKDRN 206
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
1-114 2.06e-06

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 46.73  E-value: 2.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYwsitQAIEYNLKR--TPRRIKCIIFIVWVISAVISFPPLIT----IEKE 74
Cdd:cd15202   69 GLFMCHFSNFAQYCSVHVSAYTLTAIAVDRY----QAIMHPLKPriSKTKAKFIIAVIWTLALAFALPHAICskleTFKY 144
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 695872405  75 SGKEEEPKCKIN-------EEKWYIISSCIGSFFAPCVIMVLVYIRI 114
Cdd:cd15202  145 SEDIVRSLCLEDwperadlFWKYYDLALFILQYFLPLLVISFAYARV 191
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
1-129 3.06e-06

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 46.43  E-value: 3.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLI--TIEKESGKE 78
Cdd:cd15926   70 GKAMCKIVSYVTAMNMYASVFFLTAMSVARYHSVASALKSKRRRGCCSAKWLCVLIWVLAILASLPNAIfsTTATVSNEE 149
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 695872405  79 ----EEPKCKINEEKW---YIISSCIGSFFAPCVIMVLVYIRIYQ-IAKKRTRVPPSKR 129
Cdd:cd15926  150 lclvKFPDNRGNAQFWlglYHAQKVLLGFLIPLGIISLCYLLLVRfITDKNITGSSTKR 208
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
14-131 3.22e-06

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 46.22  E-value: 3.22e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405  14 LFCtsSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLI-----TIEkesgKEEEPKCKINEE 88
Cdd:cd14985   84 MFA--SIFLLTCMSVDRYLAIVHPVASRRLRRRRQARVTCALIWVVACLLSLPTFLlrslqAIE----NLNKTACIMLYP 157
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 695872405  89 KW-----YIISSCIGSFFAPCVIMVLVYIRIYQ-IAKKRTRVPPSKRSN 131
Cdd:cd14985  158 HEawhfgLSLELNILGFVLPLLIILTCYFHIARsLRKRYERTGKNGRKR 206
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
1-129 3.27e-06

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 46.33  E-value: 3.27e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIekesGKEEE 80
Cdd:cd15928   69 GDLLCRLMYFFSETCTYASILHITALSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIVSAGPALVLV----GVEHI 144
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 695872405  81 PKC---KINEEKWYIISSCIGS---------FFAPCVIMVLVY---IRIYQIAKKRTRVPPSKR 129
Cdd:cd15928  145 QGQqtpRGFECTVVNVSSGLLSvmlwvstsfFFVPMVCLSLLYgliGRALWDRRQRSRTAGASR 208
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
14-127 3.65e-06

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 46.16  E-value: 3.65e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405  14 LFCtsSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIeKESGKEEEPKC-------KIN 86
Cdd:cd15168   84 LYG--SILFLTCISVHRYLGICHPLRSLGKLKKRHAVAISVAVWILVLLQLLPILFFA-TTGRKNNRTTCydttspeELN 160
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 695872405  87 EEKWYIISSCIGSFFAPCVIMVLVYIRIYQIAKKRTRVPPS 127
Cdd:cd15168  161 DYVIYSMVLTGLGFLLPLLIILACYGLIVRALIRKLGEGVT 201
7tmA_CXCR6 cd15173
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
1-111 4.05e-06

CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320301 [Multi-domain]  Cd Length: 270  Bit Score: 45.92  E-value: 4.05e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRI--KCIIFIVWVISAVISFPPLI-----TIEK 73
Cdd:cd15173   67 GTVMCKITNGLYTINLYSSMLILTCITVDRFIVIVQATKAHNCHAKKMRwgKVVCTLVWVISLLLSLPQFIysevrNLSS 146
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 695872405  74 ESGKEEEPKCKIneEKWYIISSCIGSFFAPCVIMVLVY 111
Cdd:cd15173  147 KICSMVYPPDAI--EVVVNIIQMTVGFFLPLLAMIICY 182
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
1-139 4.46e-06

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 45.71  E-value: 4.46e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLI---TIEKESGK 77
Cdd:cd15091   68 GDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVlggTKVREDVD 147
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 695872405  78 EEEPKCKINEEK--WYIISSCIGSFFAPCVIMVLVYIRIYQIAKkrTRVPPSKRSNGEPEKKQN 139
Cdd:cd15091  148 STECSLQFPDDDysWWDTFMKICVFIFAFVIPVLIIIVCYTLMI--LRLKSVRLLSGSREKDRN 209
7tmA_GPR87 cd15969
G protein-coupled receptor 87, member of the class A family of seven-transmembrane G ...
13-131 4.48e-06

G protein-coupled receptor 87, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR87 acts as one of multiple receptors for lysophosphatidic acid (LPA). This orphan receptor has been shown to be over-expressed in several malignant tumors including lung squamous cell carcinoma and regulated by p53. GPR87 is phylogenetically closely related to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase.


Pssm-ID: 320635 [Multi-domain]  Cd Length: 283  Bit Score: 45.94  E-value: 4.48e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405  13 VLFCTS---SIVHLCAISLDRYWSITQAIE----YNLKRTprriKCIIFIVWVISAVISFPPLITIEKESGKEEEPKC-K 84
Cdd:cd15969   77 VLFYASmytSIVFLGLISLDRYLKVVKPFGdsrmYSITFT----KVLSACVWLIMAFLSLPNIILTNGQPTEDNIHDCsK 152
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 695872405  85 INE---EKWYI----ISSCIgsFFAPCVIMVLVYIRIYQIAKKRTRVPPSKRSN 131
Cdd:cd15969  153 LKSplgVKWHTavsyINICI--FVAVLVILIVCYISISRYIYKSSKQFISSSSR 204
7tmA_GPR132_G2A cd15364
proton-sensing G protein-coupled receptor 132, member of the class A family of ...
13-130 5.19e-06

proton-sensing G protein-coupled receptor 132, member of the class A family of seven-transmembrane G protein-coupled receptors; The G2 accumulation receptor (G2A, also known as GPR132) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. G2A was originally identified as a stress-inducible receptor that causes the cell cycle arrest at G2/M phase when serum is deprived. Lysophosphatidylcholine was identified as a ligand for G2A, and whose overexpression was shown to induce cell proliferation, oncogenic transformation, and apoptosis.


Pssm-ID: 320486 [Multi-domain]  Cd Length: 279  Bit Score: 45.54  E-value: 5.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405  13 VLFCTS--SIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKEE---EP-KCKIN 86
Cdd:cd15364   79 IFFCNIyiSILLLCCISIDRFVAVVYALESRGRRRQRIAAFISFLIFIVVGLVHSPVFIMREGQTEGSHtcfETlQMDTQ 158
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 695872405  87 EEKWYIISSCIGsFFAPCVIMVLVYIRIYQIAKKRTRVPPSKRS 130
Cdd:cd15364  159 VAGFYYARFCIG-FAIPLAILIFTNYRIFRSIQTSTSLTPHQKA 201
7tmA_GPR6 cd15962
G protein-coupled receptor 6, member of the class A family of seven-transmembrane G ...
17-117 6.66e-06

G protein-coupled receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320628 [Multi-domain]  Cd Length: 268  Bit Score: 45.31  E-value: 6.66e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405  17 TSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLI----TIEKESGKEEEPKCKINeekwyi 92
Cdd:cd15962   81 TASVSSLLAITVDRYLSLYNALTYYSEKTVLGVHLMLAATWGVSLCLGLLPVLgwncLEERASCSIVRPLTKSN------ 154
                         90       100
                 ....*....|....*....|....*
gi 695872405  93 ISSCIGSFFAPCVIMVLVYIRIYQI 117
Cdd:cd15962  155 VTLLSASFFFIFILMLHLYIKICKI 179
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
5-121 6.78e-06

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 45.15  E-value: 6.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   5 CEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKEEEP--- 81
Cdd:cd15070   71 CLFMSCLLVVFTHASIMSLLAIAVDRYLRVKLTVRYRIVTTQRRIWLALGLCWLVSFLVGLTPMFGWNRKPSLESVNttp 150
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 695872405  82 -KCKineekwyiISSCIG-------SFFA----PCVIMVLVYIRIYQIAKKR 121
Cdd:cd15070  151 lQCQ--------FTSVMRmdymvyfSFFTwiliPLVIMCALYVDIFYIIRNK 194
7tmA_GPR3_GPR6_GPR12-like cd15100
G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of ...
17-130 9.00e-06

G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3. Also included in this subfamily is GPRx, also known as GPR185, which involved in the maintenance of meiotic arrest in frog oocytes.


Pssm-ID: 320228 [Multi-domain]  Cd Length: 268  Bit Score: 44.77  E-value: 9.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405  17 TSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITI----EKESGKEEEPKCKINeekwyi 92
Cdd:cd15100   81 SASVCSLLAITVDRYLSLYNALTYYSERTLTFTYVMLALLWTLALGLGLLPVLGWnclrEGSSCSVVRPLTKNH------ 154
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 695872405  93 ISSCIGSFFAPCVIMVLVYIRI--------YQIAKKRTRVPPSKRS 130
Cdd:cd15100  155 LAVLAVAFLLVFALMLQLYAQIcrivlrhaHQIALQRHFLAPSHYV 200
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
1-117 9.03e-06

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 44.75  E-value: 9.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKE-- 78
Cdd:cd15220   68 GEAECRVYIFLSVCLVSASILTISAISVERYYYIVHPMRYEVKMTIGLVAAVLVGVWVKALLLGLLPVLGWPSYGGPApi 147
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 695872405  79 EEPKCKI-----NEEKWYIISSCIGSFFAPCVIMVLVYIRIYQI 117
Cdd:cd15220  148 AARHCSLhwshsGHRGVFVVLFALVCFLLPLLLILVVYCGVFKV 191
7tmA_MC1R cd15351
melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...
11-123 1.01e-05

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320473 [Multi-domain]  Cd Length: 271  Bit Score: 44.78  E-value: 1.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405  11 LDVLFCTS---SIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISfPPLITIEKESGkeeepkckine 87
Cdd:cd15351   82 IDTMICSSvvsSLSFLGAIAVDRYITIFYALRYHSIMTLQRAVNAIAGIWLASTVSS-TLFIVYYNSNA----------- 149
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 695872405  88 ekwyIISSCIGSFFAPCVIMVLVYIRIYQIAKKRTR 123
Cdd:cd15351  150 ----VILCLIVFFLFMLVLMLVLYIHMFILACRHSQ 181
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
13-69 1.18e-05

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 44.54  E-value: 1.18e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 695872405  13 VLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLI 69
Cdd:cd14981   84 SFFGLSSLLIVCAMAVERFLAITHPFFYNSHVKKRRARLMLGAVWAFALLIASLPLL 140
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
16-123 1.19e-05

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 44.49  E-value: 1.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405  16 CT-SSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFP--PLITIEKESGKE--EEPKCKINEekw 90
Cdd:cd15131   83 CTySTILNITALSVERYFAICFPLRAKVVVTKRRVKLVILVLWAVSFLSAGPifVLVGVEHENGTNpiDTNECKATE--- 159
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 695872405  91 YIISSCIGS---------FFAPCVIMVLVYIRIYQIAKKRTR 123
Cdd:cd15131  160 YAVRSGLLTimvwvssvfFFLPVFCLTVLYSLIGRKLWRRRR 201
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
18-115 1.20e-05

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 44.36  E-value: 1.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405  18 SSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLI--TIEKESGKEEEPKCKINEEkwYIISS 95
Cdd:cd15193   86 SSILFLTGMSVDRYLAVVKLLDSRPLRTRRCALITCCIIWAVSLVLGIPSLVyrNLINESVCVEDSSSRFFQG--ISLAT 163
                         90       100
                 ....*....|....*....|
gi 695872405  96 CIGSFFAPCVIMVLVYIRIY 115
Cdd:cd15193  164 LFLTFVLPLIVILFCYCSIL 183
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
18-114 1.23e-05

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 44.30  E-value: 1.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405  18 SSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKEEE-----PKCKINEEKWYI 92
Cdd:cd15180   84 CGIFLLACISFDRYLSIVHAVQMYSRKKPMLVHLSCLIVWLFCLLLSIPDFIFLEATKDPRQNktecvHNFPQSDTYWWL 163
                         90       100
                 ....*....|....*....|....*
gi 695872405  93 ISSC---IGSFFAPCVIMVLVYIRI 114
Cdd:cd15180  164 ALRLlyhIVGFLLPLAVMVYCYTSI 188
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
1-130 1.38e-05

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 44.39  E-value: 1.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLI---TIEKESGK 77
Cdd:cd15094   68 GAAMCKIYMVLTSINQFTSSFTLTVMSADRYLAVCHPIRSMRYRTPFIAKVVCATTWSISFLVMLPIILyasTVPDSGRY 147
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 695872405  78 eeepKCKI--------NEEKWYIISSCIGSFFAPCVIMVLVYIRIyqIAKKRTRVPPSKRS 130
Cdd:cd15094  148 ----SCTIvwpdssavNGQKAFTLYTFLLGFAIPLLLISVFYTLV--ILRLRTVGPKNKSK 202
7tmA_GPR63 cd15404
G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...
1-114 1.61e-05

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320526 [Multi-domain]  Cd Length: 265  Bit Score: 44.06  E-value: 1.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEynlKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKEEE 80
Cdd:cd15404   69 GDAFCRVSAMFFWLFVMEGVAILLIISIDRFLIIVQKQD---KLNPYRAKVLIAVSWAVSFCVAFPLAVGSPDLQIPSRA 145
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 695872405  81 PKCKINEE-----KWYIISSCIGSFFAPCVIMVLVYIRI 114
Cdd:cd15404  146 PQCVFGYTtnpgyQAYVILIMLIFFFIPFMVMLYSFMGI 184
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
1-123 1.62e-05

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 44.35  E-value: 1.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWsitqAIEYNLKR--TPRRIKCIIFIVWVISAVISFPPLITIEKESGK- 77
Cdd:cd15384   69 GNTMCKLVKYLQVFGLYLSTYITVLISLDRCV----AILYPMKRnqAPERVRRMVTVAWILSPIFSIPQAVIFHVERGPf 144
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 695872405  78 -EEEPKCKIN-------EEKWYIISSCIGSFFAPCVIMVLVYIRIYQIAKKRTR 123
Cdd:cd15384  145 vEDFHQCVTYgfytaewQEQLYNMLSLVFMFPIPLVIMVTCYVLIFITLSKSSR 198
7tmA_MC2R_ACTH_R cd15350
melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of ...
10-61 1.69e-05

melanocortin receptor subtype 2, also called adrenocorticotropic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320472 [Multi-domain]  Cd Length: 270  Bit Score: 44.00  E-value: 1.69e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 695872405  10 ALDVLFCTS---SIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISA 61
Cdd:cd15350   81 IMDSLFCLSllgSIFSILAIAADRYITIFHALRYHNIMTMRRTLVILAIIWTFCG 135
7tmA_ACKR2_D6 cd15188
atypical chemokine receptor 2, member of the class A family of seven-transmembrane G ...
1-130 2.12e-05

atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR2 (also known as D6) binds non-selectively to all inflammatory CC-chemokines, but not to homeostatic CC-chemokines involved in controlling the migration of cells. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320316 [Multi-domain]  Cd Length: 278  Bit Score: 43.62  E-value: 2.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKEEE 80
Cdd:cd15188   68 GSFLCKFVSTLYTINFYSGIFFVSCMSLDKYLEIVHAQSPHRLRTRRKSLLVLVAVWVLSIALSVPDMVFVQTHHTNNGV 147
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 695872405  81 PKCKIN----EEKWYI----ISSCIGsFFAPCVIMVLVYIRIYQIAkKRTRVPPSKRS 130
Cdd:cd15188  148 WVCHADygghHTIWKLvfqfQQNLLG-FLFPLLAMVFFYSRIACVL-TRLRPPGQGRA 203
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
18-111 2.22e-05

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 43.80  E-value: 2.22e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405  18 SSIVHLCAISLDRYWSITQAIE-YNLKRTPRRIKCIifIVWVISAVISFPPLITIE-KESGKEEEPKCKIN-----EEKW 90
Cdd:cd15178   84 SGILLLACISVDRYLAIVHATRaLTQKRHLVKFVCA--GVWLLSLLLSLPALLNRDaFKPPNSGRTVCYENlgnesADKW 161
                         90       100
                 ....*....|....*....|....
gi 695872405  91 YI---ISSCIGSFFAPCVIMVLVY 111
Cdd:cd15178  162 RVvlrILRHTLGFLLPLVVMLFCY 185
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
1-131 2.43e-05

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 43.61  E-value: 2.43e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLItIEKESGKEEE 80
Cdd:cd14971   69 GDFMCKFVHYFQQVSMHASIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVAAPVLA-LHRLRNYTPG 147
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 695872405  81 PKCKINE-------EKWYIISSCIGSFFAPCVIMVLVYIR-IYQIAKKRTRVPPSKRSN 131
Cdd:cd14971  148 NRTVCSEawpsrahRRAFALCTFLFGYLLPLLLICVCYAAmLRHLWRVAVRPVLSEGSR 206
7tmA_MC4R cd15353
melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...
11-126 2.49e-05

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320475 [Multi-domain]  Cd Length: 269  Bit Score: 43.74  E-value: 2.49e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405  11 LDVLFCTS---SIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFppLITIEKESGKeeepkckine 87
Cdd:cd15353   81 IDSVICSSllaSICSLLSIAVDRYFTIFYALQYHNIMTVRRAGVIITCIWTACTVSGV--LFIIYSDSSV---------- 148
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 695872405  88 ekwyIISSCIGSFFAPCVIMVLVYIRIYQIAK---KRTRVPP 126
Cdd:cd15353  149 ----VIICLISMFFTMLALMASLYVHMFLLARlhiKRIAVLP 186
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
1-139 2.71e-05

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 43.35  E-value: 2.71e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITiekeSGKEEE 80
Cdd:cd15402   69 GYLHCQISGFLMGLSVIGSIFNITGIAINRYCYICHSLKYDKLYSDKNSLCYVLLIWVLTVAAIVPNLFV----GSLQYD 144
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 695872405  81 PK---CKINE--EKWYIISSCIGSFFAPCVIMVLVYIRIY-QIAKKRTRVPPSKRSNGEPEKKQN 139
Cdd:cd15402  145 PRiysCTFAQsvSSAYTIAVVFFHFILPIIIVTFCYLRIWiLVIQVRRRVKPDNKPKLKPHDFRN 209
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
1-114 2.81e-05

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 43.59  E-value: 2.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYwsitQAIEYNLK---RTPRRIKCIIFIVWVISAVISFPPLI-----TIE 72
Cdd:cd15191   69 GSVMCKICGSLLTLNLFASIFFITCMSVDRY----LAVVYPLRsqrRRSWQARLVCLLVWVLACLSSLPTFYfrdtyYIE 144
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 695872405  73 kESGKEeepKCKI---NEE--KWYI---ISSCIGSFFAPCVIMVLVYIRI 114
Cdd:cd15191  145 -ELGVN---ACIMafpNEKyaQWSAglaLMKNTLGFLIPLIVIATCYFGI 190
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
19-114 3.07e-05

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 43.47  E-value: 3.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405  19 SIVHLCAISLDRYWSITQAI-EYNLKRTPRRIKcIIFIVWVISAV--ISFPPLITIEK-----ESGK--EEEPKCKINEE 88
Cdd:cd15134   88 SVLTITAFSVERYLAICHPLrSHTMSKLSRAIR-IIIAIWIIAFVcaLPFAIQTRIVYleyppTSGEalEESAFCAMLNE 166
                         90       100       110
                 ....*....|....*....|....*....|.
gi 695872405  89 K-----WYIISSCIgSFFAPCVIMVLVYIRI 114
Cdd:cd15134  167 IppitpVFQLSTFL-FFIIPMIAIIVLYVLI 196
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
19-115 3.73e-05

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 42.97  E-value: 3.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405  19 SIVHLCAISLDRYWSITQAIEYNlKRTPRRIKCIIFIV-WVISAVISFPPLITIekeSGKEEEPKC-----KINEEKWYI 92
Cdd:cd15136   94 SVFTLTVITLERWYAITHAMHLN-KRLSLRQAAIIMLGgWIFALIMALLPLVGV---SSYSKTSIClpfetETPVSKAYV 169
                         90       100
                 ....*....|....*....|...
gi 695872405  93 ISSCIGSFFAPCVIMVLvYIRIY 115
Cdd:cd15136  170 IFLLLFNGLAFLIICGC-YIKIY 191
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
1-66 4.04e-05

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 42.93  E-value: 4.04e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFP 66
Cdd:cd15357   70 GPVGCYFKTALFETVCFASILSVTTVSVERYVAILHPFRAKLNSTRERALKIIVVLWVLSVLFSIP 135
7tmA_Adenosine_R_A1 cd15071
adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...
9-136 4.09e-05

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.


Pssm-ID: 341323 [Multi-domain]  Cd Length: 290  Bit Score: 42.91  E-value: 4.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   9 LALDVLFCT-SSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLI---------TIEKESGKE 78
Cdd:cd15071   74 VACPVLILTqSSILALLAIAVDRYLRVKIPTRYKSVVTPRRAAVAIAGCWILSFLVGLTPMFgwnnlnaveRAWAANSSM 153
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 695872405  79 EEPKCKINEEKwyIISSCIGSFF-------APCVIMVLVYIRIYQIAKKRTRVPPSKRSNgEPEK 136
Cdd:cd15071  154 GELVIKCQFET--VISMEYMVYFnffvwvlPPLLLMLLIYLEVFYLIRKQLNKKVSSSSS-DPQK 215
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
1-130 4.32e-05

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 42.88  E-value: 4.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISaVISFPP------LITIEKE 74
Cdd:cd15338   72 GETMCTLITALDTNSQITSTYILTVMTLDRYLATVHPIRSTKIRTPRVAVAVICLVWILS-LLSITPvwmyagLMPLPDG 150
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 695872405  75 SgkeeePKCKI---NEEK---WYIISSCIGSFFAPCVIMVLVYIRIYQiAKKRTRVPPSKRS 130
Cdd:cd15338  151 S-----VGCALllpNPETdtyWFTLYQFFLAFALPLVVICVVYFKILQ-NMASTVAPLPQRS 206
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
19-121 4.52e-05

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 42.76  E-value: 4.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405  19 SIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFP-----PLITIEKESGkeeePKC------KINE 87
Cdd:cd15206   87 STFTLVAISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLSFLIMSPilvfsNLIPMSRPGG----HKCrevwpnEIAE 162
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 695872405  88 EKWYIISSCIgSFFAPCVIMVLVYIRIYQ---IAKKR 121
Cdd:cd15206  163 QAWYVFLDLM-LLVIPGLVMSVAYGLISWtllEAKKR 198
7tmA_CCR10 cd15177
CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...
1-111 4.53e-05

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341332 [Multi-domain]  Cd Length: 280  Bit Score: 42.84  E-value: 4.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKR--TPRRIKCIIFIVWVISAVISFPPLItIEKESGKE 78
Cdd:cd15177   67 GNAMCKLIQGLYAINFYSGFLFLTCISVDRYVVIVRATSAHRLRpkTLFYSVLTSLIVWLLSILFALPQLI-YSRVENRS 145
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 695872405  79 EEPKCKI------NEEKW--YIISSCIGSFFAPCVIMVLVY 111
Cdd:cd15177  146 ELSSCRMifpevvSRTVKgaTALTQVVLGFAIPLIVMAVCY 186
7tmA_PD2R2_CRTH2 cd15118
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
1-128 4.66e-05

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.


Pssm-ID: 320246 [Multi-domain]  Cd Length: 284  Bit Score: 42.87  E-value: 4.66e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLI---TIEKESGK 77
Cdd:cd15118   68 GTTFCRIHSSIFFLNMFVSGFLLAAISLDRCLLVVKPVWAQNHRNVAAAKKICGVIWAMALINTIPYFVfrdVIERKDGR 147
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 695872405  78 ---------------EEEPKCKINEEKwYIISSCIGSFFAPCVIMVLVYIRIYQIAKKRTRVPPSK 128
Cdd:cd15118  148 klcyynfalfspspdNNHPICKQRQEG-LAISKLLLAFLIPLVIIAVSYAVVSLIIRHRCRRRPGR 212
7tmA_P2Y12-like cd15924
P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of ...
13-139 5.60e-05

P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y12-like receptors as well as closely related orphan receptor, GPR87.


Pssm-ID: 341352 [Multi-domain]  Cd Length: 284  Bit Score: 42.43  E-value: 5.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405  13 VLFCTS---SIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKEEEPKC-KINEE 88
Cdd:cd15924   77 VLFYFTmytSIVFLGLISIDRYLKIVRPFKTSFPKSVSFAKILSVVVWALMFLLSLPNMILTNQQPREKNVKKCsFLKSE 156
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 695872405  89 ---KWYIISS--CIGSFFAPCVIMVLVYIRIYQIAKKRTRvpPSKRSNGEPEKKQN 139
Cdd:cd15924  157 lglKWHEIVNyiCQVIFWIVFLLMIVCYTAITKKVYRSYR--RVFRSSSSRRKKSN 210
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
1-90 6.53e-05

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 42.41  E-value: 6.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLI--TIEKESGKE 78
Cdd:cd15117   68 GWFLCKLYSTLVVFNLFASVFLLTLISLDRCVSVLWPVWARNHRTPARAALVAVGAWLLALALSGPHLVfrDTRKENGCT 147
                         90
                 ....*....|..
gi 695872405  79 EepkCKINEEKW 90
Cdd:cd15117  148 H---CYLNFDPW 156
7tmA_Cannabinoid_R cd15099
cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled ...
17-69 6.76e-05

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320227 [Multi-domain]  Cd Length: 281  Bit Score: 42.13  E-value: 6.76e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 695872405  17 TSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLI 69
Cdd:cd15099   85 TASVGSLLLTALDRYLCIYQPSNYKLLVTRTRAKVAILLMWCVTIIISFLPLM 137
7tmA_LPAR3_Edg7 cd15343
lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial ...
17-124 7.72e-05

lysophosphatidic acid receptor subtype 3 (LPAR3 or LPA3), also called endothelial differentiation gene 7 (Edg7), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320465 [Multi-domain]  Cd Length: 274  Bit Score: 42.17  E-value: 7.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405  17 TSSIVHLCAISLDRYWSITQ-AIEYNLkrTPRRIKCIIFIVWVISAVISFPPLITIekesgkeeepKCKINeekwyiISS 95
Cdd:cd15343   84 SASLTNLLVIAVERHISIMRmKVHSNL--TKRRVTLLIALVWAIAIFMGAVPTLGW----------NCICN------ISA 145
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 695872405  96 CigSFFAPC-----------------VIMVLVYIRIYQIAKKRTRV 124
Cdd:cd15343  146 C--SSLAPIysrsylvfwsvsnlvvfLIMVVVYLRIYVYVQRKTNV 189
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
11-123 8.60e-05

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 41.85  E-value: 8.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405  11 LDVLFCTSSIVHLC---AISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISfppLITIekesgkeeepkckINE 87
Cdd:cd15354   82 FDSLICISVVASMCsllAIAVDRYVTIFYALRYHNIMTVRRAGIIIACIWTFCTGCG---IIFI-------------LYS 145
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 695872405  88 EKWYIISSCIGSFFAPCVIMVLVYIRIYQIAKKRTR 123
Cdd:cd15354  146 ESTYVIICLITMFFAMLFLMVSLYIHMFLLARTHVK 181
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
1-69 8.80e-05

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 42.06  E-value: 8.80e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLI 69
Cdd:cd15116   68 GRFMCKLNSFLLFLNMFTSVFLLTVISIDRCISVVFPVWSQNHRSVRLASLVSLAVWVVAFFLSSPSFI 136
7tmA_MC3R cd15352
melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...
11-137 8.94e-05

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320474 [Multi-domain]  Cd Length: 272  Bit Score: 41.80  E-value: 8.94e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405  11 LDVLFCTS---SIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESgkeeepkckine 87
Cdd:cd15352   82 FDSMICISlvaSICNLLAIAVDRYVTIFYALRYHSIMTVRKALVLIAVIWVVCIVCGIVFIVYSESKT------------ 149
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 695872405  88 ekwyIISSCIGSFFAPCVIMVLVYIRIYQIA----KKRTRVPPSkrSNGEPEKK 137
Cdd:cd15352  150 ----VIVCLITMFFAMLVLMATLYVHMFLFArlhvKRIAALPPA--VDGAPQQR 197
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
18-114 1.00e-04

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 41.66  E-value: 1.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405  18 SSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLI---TIE-KESG--------KEEEpkcki 85
Cdd:cd15162   86 CSILLLTCISIDRYLAIVHPMGHRRLRARRYALGTCLAIWLLALLVTLPLYLvkqTIFlPALDittchdvlPEQL----- 160
                         90       100       110
                 ....*....|....*....|....*....|.
gi 695872405  86 NEEKW--YIISSCIGSFFAPCVIMVLVYIRI 114
Cdd:cd15162  161 LVGDWfyYFLSLAIVGFLIPFILTASCYVAT 191
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
1-114 1.21e-04

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 41.55  E-value: 1.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCeiYLALDVLFCTS--SIVHLCAISLDRYwsitQAIEYNLKRTPRRIKCIIFIV--WVISAVISFP-----PLITI 71
Cdd:cd15389   69 GKIMC--HLSRFAQYCSVyvSTLTLTAIALDRH----RVILHPLKPRITPCQGVVVIAiiWIMASCLSLPhaiyqKLVEF 142
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 695872405  72 EKESGKEEE------PKCKINEEKWYIISSCIGSFFAPCVIMVLVYIRI 114
Cdd:cd15389  143 EYSNERTRSrclpsfPEPSDLFWKYLDLATFILQYVLPLLIIGVAYTRV 191
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
16-76 1.64e-04

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 41.32  E-value: 1.64e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 695872405  16 CTSS-IVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVIsAVISFPP---LITIEKESG 76
Cdd:cd15132   83 CTYAtILHITALSIERYLAICFPLRAKVLVTRRRVKCVIAALWAF-ALLSAGPflfLVGVEQDNN 146
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
5-123 1.94e-04

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 40.90  E-value: 1.94e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   5 CEIYLALDVLFCTSSIVHLCAISLDRYwsitQAIEYNLK----RTPRRIKCIIFIVWVISAVISFPplitIEKESGKEEE 80
Cdd:cd15923   71 CNFVLSLYYINMYVSIFTITAISVDRY----VAIRYPLRarelRSPRKAAVVCAVIWVLVVTISIP----YFLLDSSNEK 142
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 695872405  81 PKC----KINEEKWYIISSCIGSFFAPCVIMVLVYIRIYQIAKKRTR 123
Cdd:cd15923  143 TMCfqrtKQTESLKVFLLLEIFGFLLPLIIMTFCSARVIHTLQKRLD 189
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
1-124 2.14e-04

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 40.81  E-value: 2.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRtpRRIKCIIFIVWVISAVISFPPLI---TIEKESGk 77
Cdd:cd15383   70 GDLACRLLMFLKLFAMYSSAFVTVVISLDRHAAILNPLAIGSAR--RRNRIMLCAAWGLSALLALPQLFlfhTVTATPP- 146
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 695872405  78 EEEPKCKIN-------EEKWYIISSCIGSFFAPCVIMVLVYIRI-YQIAKKRTRV 124
Cdd:cd15383  147 VNFTQCATHgsfpahwQETLYNMFTFFCLFLLPLLIMIFCYTRIlLEISRRMKEK 201
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
1-128 2.27e-04

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 40.55  E-value: 2.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAieyNLKR---TPRRIKCIIFIVWVISAVISFPPLITIEKESGK 77
Cdd:cd15199   69 GGGTCKALLFMLSLSRGVSIAFLTAVALDRYFRVVHP---RGKKnslSLQAAPYISFLVWLLLVGLTIPTLLASQPKNFT 145
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 695872405  78 EEEPKCKINEEK----WYIISSCIgSFFAPCVIMVLVYIRIYQIAKKRTRVPPSK 128
Cdd:cd15199  146 ECNSFSPKDDEDfsdtWQEAVFFL-QFLLPFGLIVFCTVRIIRRLKKRLRDVGKQ 199
7tmA_GPR39 cd15135
G protein-coupled receptor 39, member of the class A family of seven-transmembrane G ...
1-74 2.68e-04

G protein-coupled receptor 39, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR39 is an orphan G protein-coupled receptor that belongs to the growth hormone secretagogue and neurotensin receptor subfamily. GPR39 is expressed in peripheral tissues such as pancreas, gut, gastrointestinal tract, liver, kidney as well as certain regions of the brain. The divalent metal ion Zn(2+) has been shown to be a ligand capable of activating GPR39. Thus, it has been suggested that GPR39 function as a G(q)-coupled Zn(2+)-sensing receptor which involved in the regulation of endocrine pancreatic function, body weight, gastrointestinal mobility, and cell death.


Pssm-ID: 320263 [Multi-domain]  Cd Length: 320  Bit Score: 40.55  E-value: 2.68e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRtPRRIKCIIFIVWVISAVISFPPLITIEKE 74
Cdd:cd15135   74 GNIACKIYNFLFEACSYATILNVATLSFERYIAICHPFKYKALS-GSRVRLLICFVWLTSALVALPLLFAMGTE 146
7tmA_P2Y13 cd15151
P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled ...
13-114 3.21e-04

P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y13 receptor (P2Y13R) is activated by adenosine diphosphate (ADP) and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341327  Cd Length: 284  Bit Score: 40.15  E-value: 3.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405  13 VLFCTS---SIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKEEEPKCKINEE- 88
Cdd:cd15151   77 VVFYITmyiSIILLGLISFDRYLKIVRPFGKSWVQRVRFAKILSGAVWLVMFLLSVPNMILSNKPATPISVKKCASLKSp 156
                         90       100       110
                 ....*....|....*....|....*....|.
gi 695872405  89 ---KWY--IISSCIGSFFAPCVIMVLVYIRI 114
Cdd:cd15151  157 lglKWHevVNYICQFIFWGVFALMVLFYTII 187
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
1-114 3.54e-04

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 40.13  E-value: 3.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEI--YLALDVLFctSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLItIEKESGKE 78
Cdd:cd15190   80 GSFLCKLssYLVFVNMY--ASVFCLTGLSFDRYLAIVRSLASAKLRSRTSGIVALGVIWLLAALLALPALI-LRTTSDLE 156
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 695872405  79 EEPKCK---------INEEKWYII-----SSCIGSFFAPCVIMVLVYIRI 114
Cdd:cd15190  157 GTNKVIcdmdysgvvSNESEWAWIaglglSSTVLGFLLPFLIMLTCYFFI 206
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
1-69 3.61e-04

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 40.11  E-value: 3.61e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLI 69
Cdd:cd15119   68 GVWLCKINSFVAVLNMFASVLFLTVISLDRYISLAHPVWSHRYRTLKSALILCGIVWLSAAAISGPALY 136
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
1-138 3.83e-04

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 40.21  E-value: 3.83e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFP---PLITIEKESGK 77
Cdd:cd15133   70 GSGGCYFKTFLFETVCLASILNVTALSVERYIAVVHPLAARTCSTRPRVTRVLGCVWGVSMLCALPntsLHGIKFLGSGV 149
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 695872405  78 EEEPKCKINEEKWYI-----ISSCIGSFFAPCVIMVLVYIRIYQIAKKR---TRVPPSKRSNGEPEKKQ 138
Cdd:cd15133  150 PASAQCTVRKPQAIYnmipqHTGHLFFVLPMAVISVLYLLMALRLARERgldATGAGSKIGTRTGQLLQ 218
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
1-69 3.96e-04

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 40.10  E-value: 3.96e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLI 69
Cdd:cd14977   69 GDVMCKLVPFIQVTSLGVTVFSLCALSIDRYRAAVNSMPMQTIGACLSTCVKLAVIWVGSVLLAVPEAV 137
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
1-141 4.14e-04

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 40.15  E-value: 4.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITiekeSGKEEE 80
Cdd:cd15209   69 GQLHCQASGFIMGLSVIGSIFNITAIAINRYCYICHSLQYDRLYSLRNTCCYLCLTWLLTVLAVLPNFFI----GSLQYD 144
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 695872405  81 PK---CKINE--EKWYIISSCIGSFFAPCVIMVLVYIRIY-QIAKKRTRVPPSKRSNGEPEKKQNGL 141
Cdd:cd15209  145 PRiysCTFAQtvSTVYTITVVVIHFLLPLLIVSFCYLRIWvLVLQVRQRVKPDQRPKLKPADVRNFL 211
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
23-113 8.43e-04

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 39.04  E-value: 8.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405  23 LCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLI---TIEKESGKEEEPKCKINEEKWYIISSCIGS 99
Cdd:cd15097   92 LAAVSVDRYLAIRYPLRSRELRTPRNAVAAIALIWGLSLLFAGPYLSyydLIDYANSTVCMPGWEEARRKAMDTCTFAFG 171
                         90
                 ....*....|....
gi 695872405 100 FFAPCVIMVLVYIR 113
Cdd:cd15097  172 YLIPVLVVSLSYTR 185
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
1-70 1.00e-03

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 38.95  E-value: 1.00e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRT--PRRIKCIIfiVWVISAVISFPPLIT 70
Cdd:cd15192   69 GNFLCKIASALVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTlvVARVTCIV--IWLLAGVASLPAIIH 138
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
5-119 1.05e-03

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 38.65  E-value: 1.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   5 CEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEyNLKRTPRRIKCIIFIVWVISAVISFP-----PLITIEKESGKEE 79
Cdd:cd15385   73 CRIVKHLQVLGMFASTYMLVMMTADRYIAICHPLK-TLQQPTKRSYLMIGSAWALSFILSTPqyfifSLSEIENGSGVYD 151
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 695872405  80 ------EPKckinEEKWYIISSCIGSFFAPCVIMVLVYIRI-YQIAK 119
Cdd:cd15385  152 cwanfiVPW----GIKAYITWITISIFVVPVIILLTCYGFIcYNIWR 194
7tmA_GPR176 cd15006
orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; ...
3-117 1.39e-03

orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; GPR176 is a putative G protein-coupled receptor that belongs to the class A GPCR superfamily; no endogenous ligand for GPR176 has yet been identified. The class A rhodopsin-like GPCRs represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320135 [Multi-domain]  Cd Length: 289  Bit Score: 38.32  E-value: 1.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   3 VWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRiKCIIFIvWViSAVISFPPLITIEkesgkeeepk 82
Cdd:cd15006   73 LFCKVIKFLHKVFCSVTVLSFAAIALDRYYSVLYPLERKISDAKSR-DLVIYI-WA-HAVVASVPVFAVT---------- 139
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 695872405  83 ckiNEEKWYIISSCIGSFFAPcvIMVLVYIRIYQI 117
Cdd:cd15006  140 ---NVTDIYAMSTCTESWGYS--LGHLVYVIIYNI 169
7tmA_GPR34-like cd15148
putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G ...
19-131 1.51e-03

putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 34 of unknown function. Orphan GPR34 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320276 [Multi-domain]  Cd Length: 282  Bit Score: 38.14  E-value: 1.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405  19 SIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKEsgkEEEPKC----KINEEKW---- 90
Cdd:cd15148   87 SIILLGFISLDRYLKINRSSRRQKFLTRKWSIVACGVLWAVALVGFVPMIVLTEKN---EESTKCfqykDRKNAKGkaif 163
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 695872405  91 -YIIsscIGSFFAPCVIMVLVYIRI----YQIAKKRTRVPPSKRSN 131
Cdd:cd15148  164 nFLI---VAMFWLVFLLLILSYGKIakklLRISRDKPDFPNAAKYN 206
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
1-121 1.60e-03

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 38.26  E-value: 1.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFP-PLITIEKESGKEE 79
Cdd:cd15979   69 GEVICKAVAYLMGVSVSVSTFSLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGLIMIPyPVYSVTVPVPVGD 148
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 695872405  80 EP---KCKIN------EEKWYIISSCIgSFFAPCVIMVLVYIRIYQ------IAKKR 121
Cdd:cd15979  149 RPrghQCRHAwpsaqvRQAWYVLLLLI-LFFIPGVVMIVAYGLISRelyrglLAKKR 204
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
1-114 1.63e-03

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 38.21  E-value: 1.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLI--TIEKESGKE 78
Cdd:cd15115   68 GRFLCKLLPSIIVLNMFASVFTLTAISLDRFLLVIKPVWAQNHRSVLLACLLCGCIWILALLLCLPVFIyrTTVTDGNHT 147
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 695872405  79 EepkCKINEEKWYIISSCIGSFFAPCVIMVLVYIRI 114
Cdd:cd15115  148 R---CGYDFLVAITITRAVFGFLLPLLIIAACYSFI 180
7tmA_PAFR cd15147
platelet-activating factor receptor, member of the class A family of seven-transmembrane G ...
18-70 1.96e-03

platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The platelet-activating factor receptor is a G(q/11)-protein coupled receptor, which is linked to p38 MAPK and PI3K signaling pathways. PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) which is synthesized by cells especially involved in host defense such as platelets, macrophages, neutrophils, and monocytes. PAF is well-known for its ability to induce platelet aggregation and anaphylaxis, and also plays important roles in allergy, asthma, and inflammatory responses, among many others.


Pssm-ID: 320275 [Multi-domain]  Cd Length: 291  Bit Score: 37.81  E-value: 1.96e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 695872405  18 SSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLIT 70
Cdd:cd15147   88 CSVAFLGVISYNRYQAVTRPIKTAQSTTRKRGIIISVAIWVIIVASASYFLFM 140
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
1-123 1.98e-03

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 37.97  E-value: 1.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITiekeSGKEEE 80
Cdd:cd15401   69 GNIHCQISGFLMGLSVIGSVFNITAIAINRYCYICHSLRYDKLYNMKKTCCYVCLTWVLTLAAIVPNFFV----GSLQYD 144
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 695872405  81 PK---CKINE--EKWYIISSCIGSFFAPCVIMVLVYIRIYQI---AKKRTR 123
Cdd:cd15401  145 PRiysCTFAQtvSSSYTITVVVVHFIVPLSIVTFCYLRIWVLviqVKHRVR 195
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
14-136 2.00e-03

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 37.78  E-value: 2.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405  14 LFCTS---SIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLIT--IEKESGKEEEPKCKIN-- 86
Cdd:cd15098   81 FFTVSmlvSIFTLVAMSVDRYIAVVHSRTSSSLRTRRNALLGVLVIWVLSLAMASPVAVHqdLVHHWTASNQTFCWENwp 160
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 695872405  87 EEKW---YIISSCIGSFFAPCVIMVLVYIRIYQIAKKRTRvPPSKRSNGEPEK 136
Cdd:cd15098  161 EKQQkpvYVVCTFVFGYLLPLLLITFCYAKVLNHLHKKLK-NMSKKSERSKKK 212
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
1-129 2.38e-03

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 37.81  E-value: 2.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVIsaVISFP-PLITIEKESGKEE 79
Cdd:cd14991   69 GEAWCRVNLFMLSVNRSASIAFLTAVALDRYFKVVHPHHRVNRMSVKAAAGVAGLLWAL--VLLLTlPLLLSTLLTVNSN 146
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 695872405  80 EPKCK--INEEK------WYIISSCIgSFFAPCVIMVLVYIRIYQIAKKRTRVPPSKR 129
Cdd:cd14991  147 KSSCHsfSSYTKpslsirWHNALFLL-EFFLPLGLIVFCSVRIACNLRIRQSLGKQAR 203
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
18-114 2.39e-03

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 37.84  E-value: 2.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405  18 SSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESG----KEEEPKCkiNEEKW--- 90
Cdd:cd15205   86 TSILTMTCIAVERHQGIVHPLKMKWQYTNRRAFTMLGLVWIVSVIVGSPMLFVQQLEVKydflYEKRHVC--CLERWysp 163
                         90       100
                 ....*....|....*....|....*....
gi 695872405  91 -----YIISSCIGSFFAPCVIMVLVYIRI 114
Cdd:cd15205  164 tqqkiYTTFILVILFLLPLTTMLFLYSRI 192
7tmA_FFAR2_FFAR3 cd15170
free fatty acid receptors 2, 3, and similar proteins, member of the class A family of ...
18-129 2.43e-03

free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes free fatty acid receptor 2 (FFAR2), FFAR3, and similar proteins. They are a member of the class A G-protein coupled receptors that bind free fatty acids. The FFAR subfamily is composed of three receptors, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR2 and FFAR3 are cell-surface receptors for short chain FFAs (SCFAs) with different ligand affinities, whereas FFAR1 is a receptor for medium- and long-chain FFAs. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), thus suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320298  Cd Length: 278  Bit Score: 37.62  E-value: 2.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405  18 SSIVHLCAISLDRYWSITQAIEYNLKRTPRR--IKCIIFivWVISA-------VISFPPLITIEKESgkeEEPKC--KIN 86
Cdd:cd15170   87 ISTLFLTAISVERYLGVAFPIKYKLRRRPLYavIASVFF--WVLAFshcsivyIVEYHIDSENTSVT---NNSRCydNFT 161
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 695872405  87 EEKWYII-----SSCIGSFFAPCVIMVLVYIRIYQIAKKRTRVPPSKR 129
Cdd:cd15170  162 PEQLKILlpvrlELFLVLFCIPFLITCFCYINFIRILSSLPHISRQRK 209
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
1-112 2.47e-03

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 37.81  E-value: 2.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEI-YLALDV-LFctSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPP---LITIEKES 75
Cdd:cd14987   69 GEFTCKItHLIFSInLF--GSIFFLTCMSVDRYLSVTLFGNTSSRRKKIVRRIICVLVWLLAFVASLPDtyfLKTVTSPS 146
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 695872405  76 GKEEEPKCKINEE---KWYI---ISSCIGSFFAPCVIMVLVYI 112
Cdd:cd14987  147 NNETYCRSFYPEEsfkEWLIgmeLVSIVLGFVIPFPIIAVFYF 189
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
1-81 2.51e-03

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 37.62  E-value: 2.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITI--EKESGKE 78
Cdd:cd15130   74 GDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFTMglQNESDDG 153

                 ...
gi 695872405  79 EEP 81
Cdd:cd15130  154 THP 156
7tmA_GPR12 cd15961
G protein-coupled receptor 12, member of the class A family of seven-transmembrane G ...
17-120 2.78e-03

G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320627 [Multi-domain]  Cd Length: 268  Bit Score: 37.31  E-value: 2.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405  17 TSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIekeSGKEEEPKCKI----NEEKWYI 92
Cdd:cd15961   81 SASVCSLLAITVDRYLSLYYALTYNSERTVTFTYVMLVLLWGASICLGLLPVMGW---NCLADESTCSVvrplTKNNAAI 157
                         90       100
                 ....*....|....*....|....*...
gi 695872405  93 ISScigSFFAPCVIMVLVYIRIYQIAKK 120
Cdd:cd15961  158 LSV---SFLLMFALMLQLYIQICKIVMR 182
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
1-129 2.88e-03

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 37.38  E-value: 2.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVIsAVISFPPLITIEKESGKEEE 80
Cdd:cd15161   69 GEVPCRLAGFLFYLNMYASLYFLACISVDRFLAIVHPVKSMKIRKPLYAHVVCGFLWVI-VTVAMAPLLVSPQTVEVNNT 147
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 695872405  81 PKCkineEKWYI-------ISSCIGSFFAPCVIMVLVYIRIYQIAKKRTRV-PPSKR 129
Cdd:cd15161  148 TVC----LQLYRekasrgaLVSLAVAFTIPFVTTVTCYLLIIRSLRTGKREeKPLKD 200
7tmA_CB2 cd15341
cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G ...
17-69 3.53e-03

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 320463 [Multi-domain]  Cd Length: 279  Bit Score: 37.13  E-value: 3.53e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 695872405  17 TSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLI 69
Cdd:cd15341   85 TASLGSLLLMAFDRYVCIYYPSEYKALVTRKRALVALAVMWVLTALIAYLPLM 137
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
1-137 3.76e-03

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 37.03  E-value: 3.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYnlKRTPRRI----KCIIFIVWVISAVISFPPLITIEKESG 76
Cdd:cd15087   68 GELLCKLILSIDHYNIFSSIYFLTVMSVDRYLVVLATVRS--RRMPYRTyraaKIVSLCVWLLVTIIVLPFTVFAGVYSN 145
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 695872405  77 KEEEPKCKIN----EEKWYIIS---SCIGSFFAP-CVIMVLVYIRIYQIakKRTRVPPSKRSNGEPEKK 137
Cdd:cd15087  146 ELGRKSCVLSfpspESLWFKASriyTLVLGFAIPvSTICILYTMMLYKL--RNMRLNSNAKALDKAKKK 212
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
1-111 4.79e-03

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 36.77  E-value: 4.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIkcIIFIVWVISAVISFPplitIEKESGKEEE 80
Cdd:cd16002   69 GLEYCKFHNFFPIAAVFASIYSMTAIALDRYMAIIHPLQPRLSATATKV--VICVIWVLAFLLAFP----QGYYSDTEEM 142
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 695872405  81 PK---CKIN--------EEKWYIISSCIGSFFAPCVIMVLVY 111
Cdd:cd16002  143 PGrvvCYVEwpeheerkYETVYHVCVTVLIYFLPLLVIGCAY 184
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
1-115 4.82e-03

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 36.59  E-value: 4.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLI---TIEKESGK 77
Cdd:cd14995   71 GYAGCLLITYLQYLGINASSLSITAFTIERYIAICHPMKAQFICTVSRAKKIICFVWIFTSLYCSPWLFlldLSIKHYGD 150
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 695872405  78 EEEPKC--KINEEKWYIIsscigsFFAPC----VIMVLVYIRIY 115
Cdd:cd14995  151 DIVVRCgyKVSRHYYLPI------YLADFvlfyVIPLLLAIVLY 188
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
19-114 4.91e-03

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 36.65  E-value: 4.91e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405  19 SIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPplITIEKESGKEEEPK---CK----INEEK-- 89
Cdd:cd15372   86 SVLLLMCISLDRYLAVVHPFFARTLRSRRFALCMCTAIWLIAAALTLP--LTLQRQSYPLERLNitlCHdvlpLDEQDty 163
                         90       100
                 ....*....|....*....|....*..
gi 695872405  90 WYIISSCIG--SFFAPCVIMVLVYIRI 114
Cdd:cd15372  164 LFYYFACLAvlGFLLPLVVILFCYGSV 190
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
18-83 5.14e-03

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 36.68  E-value: 5.14e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 695872405  18 SSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGkeEEPKC 83
Cdd:cd14988   86 SSIFFLTCLSVDRYLTLTSSSPFWQQHQHRIRRALCAGIWVLSAIIPLPEVVHMQLLDG--VEPMC 149
7tmA_P2Y14 cd15149
P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled ...
19-114 5.32e-03

P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y14 receptor is activated by UDP-sugars and belongs to the G(i) class of the P2Y family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14). P2Y14 receptor has been reported to be involved in a diverse set of physiological responses in many epithelia as well as in immune and inflammatory cells.


Pssm-ID: 320277 [Multi-domain]  Cd Length: 284  Bit Score: 36.75  E-value: 5.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405  19 SIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKEEEPKC-KINEE---KWYIIS 94
Cdd:cd15149   86 GIIFFGLIGFDRYYKIVKPLHTSFVQNVGYSKALSVVVWMLMAVLSVPNIILTNQSFHEANYTKCaRLKSElgiQWHKAS 165
                         90       100
                 ....*....|....*....|..
gi 695872405  95 S--CIGSFFAPCVIMVLVYIRI 114
Cdd:cd15149  166 NyiCVSIFWVVFLLLIIFYVAI 187
7tmA_GPR20 cd15163
G protein-coupled receptor 20, member of the class A family of seven-transmembrane G ...
14-114 5.64e-03

G protein-coupled receptor 20, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan GPR20 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR20 has been shown to constitutively activate G(i) proteins in the absence of a ligand; however its functional role is not known. GPR20 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320291 [Multi-domain]  Cd Length: 258  Bit Score: 36.69  E-value: 5.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405  14 LFCtsSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESGKeeePKCKineekwyII 93
Cdd:cd15163   81 MYC--SILFLTCICVDRYLAIVQVEASRRWRNPNYAKGICVFIWLFAIVVTFSILTTAIKFASC---CLSK-------LF 148
                         90       100
                 ....*....|....*....|.
gi 695872405  94 SSCIGSFFAPCVIMVLVYIRI 114
Cdd:cd15163  149 ALTVFEFFLPLLIITFFTIRI 169
7tmA_GPR3 cd15963
G protein-coupled receptor 3, member of the class A family of seven-transmembrane G ...
17-118 5.78e-03

G protein-coupled receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320629 [Multi-domain]  Cd Length: 268  Bit Score: 36.40  E-value: 5.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405  17 TSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITI----EKESGKEEEPKCKINeekwyi 92
Cdd:cd15963   81 TASVSSLLAITIDRYLSLYNALTYYSERTVTRTYIMLILTWGASLCLGLLPVVGWnclkDPSTCSVVKPLTKNH------ 154
                         90       100
                 ....*....|....*....|....*.
gi 695872405  93 ISSCIGSFFAPCVIMVLVYIRIYQIA 118
Cdd:cd15963  155 LVILSISFFMVFALMLQLYAQICRIV 180
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
18-114 6.15e-03

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 36.37  E-value: 6.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405  18 SSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKESgKEEEPKCkiNEEK-------W 90
Cdd:cd15194   86 CSVFLLTCMSLDRYLAIVLPLVSRKFRTKHNAKVCCTCVWMLSCLLGLPTLLSRELKK-YEEKEYC--NEDAgtpskviF 162
                         90       100
                 ....*....|....*....|....
gi 695872405  91 YIIsSCIGSFFAPCVIMVLVYIRI 114
Cdd:cd15194  163 SLV-SLIVAFFLPLLSILTCYCTI 185
7tmA_PAR1 cd15369
protease-activated receptor 1, member of the class A family of seven-transmembrane G ...
14-116 7.66e-03

protease-activated receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320491  Cd Length: 281  Bit Score: 36.28  E-value: 7.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405  14 LFCtsSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEkesgKEEEPKCKI-------- 85
Cdd:cd15369   84 MYC--SILLMTCISVDRFLAVVYPMQSLSWRTLRRASFTCAAIWLLSIAGVVPLLLSEQ----TIQIPDLGIttchdvln 157
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 695872405  86 -NEEKWYII----SSCIGSFFAPCVIMVLVYIRIYQ 116
Cdd:cd15369  158 eQLLMGYYVyyfsIFSCLFFFVPLIITTVCYVSIIR 193
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
1-124 7.75e-03

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 36.25  E-value: 7.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIfIVWVISAVISFPPLITIEKESGKEEE 80
Cdd:cd15086   69 GEHGCRWYGFANSLFGIVSLISLAVLSYERYCTLLRPTEADVSDYRKAWLGVG-GSWLYSLLWTLPPLLGWSSYGPEGPG 147
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 695872405  81 PKCKIN------EEKWYIISSCIGSFFAPCVIMVLVYIRIYQIAKKRTRV 124
Cdd:cd15086  148 TTCSVQwtsrsaNSISYIICLFIFCLLLPFLVMVYCYGRLLYAIKQVGKI 197
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
1-66 8.79e-03

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 36.06  E-value: 8.79e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 695872405   1 GKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIkcIIFIVWVISAVISFP 66
Cdd:cd16003   69 GEAYCRFHNFFPITSVFASIYSMTAIAVDRYMAIIDPLKPRLSATATKV--VIGSIWILAFLLAFP 132
7tmA_GPER1 cd14989
G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G ...
18-129 9.62e-03

G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled estrogen receptor 1 (GPER1), also known as the G-protein coupled receptor 30 (GPR30), is a high affinity receptor for estrogen. This receptor is a member of the class A of seven-transmembrane GPCRs. Estrogen binding results in intracellular calcium mobilization and synthesis of phosphatidylinositol (3,4,5)-trisphosphate in the nucleus. GPR30 plays an important role in development of tamoxifen resistance in breast cancer cells. The distribution of GPR30 is well established in the rodent, with high expression observed in the hypothalamus, pituitary gland, adrenal medulla, kidney medulla and developing follicles of the ovary. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320120 [Multi-domain]  Cd Length: 276  Bit Score: 35.96  E-value: 9.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695872405  18 SSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLiTIEKESGKEEEPKC--KINEEKWYIISs 95
Cdd:cd14989   84 SSIFFLTWMSFDRYIALAKVMKSSPLRTMQHARLSCGLIWMASISATLLPF-TAVQAQHTGEVHFCfaDVREIQWLEVT- 161
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 695872405  96 cIGsFFAPCVIMVLVY---IRIYQIAKKRTRVPPSKR 129
Cdd:cd14989  162 -LG-FIIPFSIIGLCYsliVRVLVRAQKHRRLRPRRQ 196
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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