|
Name |
Accession |
Description |
Interval |
E-value |
| actP |
PRK09395 |
cation/acetate symporter ActP; |
3-556 |
0e+00 |
|
cation/acetate symporter ActP;
Pssm-ID: 236495 Cd Length: 551 Bit Score: 835.78 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 3 LLGWTSGANAAIAGAVQRQPTNWTAILMFGAFVGITLWITGAAARRTRTVSDFYT-GGGITGFQNGLAMAGDYCSAASFL 81
Cdd:PRK09395 12 LLPAAAAAADAISGEVEKQPTNWQAIIMFLIFVVFTLGITYWAAKRTRSASDFYTaGGGITGFQNGLAIAGDYMSAASFL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 82 GITSQIFNDGYDGLIYAIGFLVGWPIVLFLIAEKLRNLGRFTFADVASYRFLQGPVRSFSAISTLLVVSFYLIAQMVGAG 161
Cdd:PRK09395 92 GISALVFTSGYDGLIYSIGFLVGWPIILFLIAERLRNLGKYTFADVASYRLKQGPIRTLSACGSLVVVALYLIAQMVGAG 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 162 QLVQLLFGLPYLYAIVVVGGLMMVYVLFGGMRATSWVQIIKAVMLLCGATFLVLGVMAHVGFSFEALFARAVAVKtklal 241
Cdd:PRK09395 172 KLIQLLFGLNYHVAVVLVGVLMMVYVLFGGMLATTWVQIIKAVLLLSGATFMAFMVMKHVGFSFENLFSEAVAVH----- 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 242 dsglapgdaaAKGRAIMGPGGFIKDPISALSFGFALMLGTAGLPHILMRFFTVPDAREARKSIMWATVWIGYFYALTFVL 321
Cdd:PRK09395 247 ----------PKGLAIMGPGGLVKDPISALSLGLALMFGTAGLPHILMRFFTVSDAKEARKSVFYATGFIGYFYILTFII 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 322 GFGAIVMISFNPDYVDAAGALRGGNNMAVMHLAHAIGGNLFLGFISAVAFATILAVVAGLTLSAASAISHDVYASVIRKG 401
Cdd:PRK09395 317 GFGAIVLVGTNPEFKDAAGALIGGNNMAAVHLANAVGGNLFLGFISAVAFATILAVVAGLTLAGASAVSHDLYANVIKKG 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 402 DADPGKELRVSRITTILLGIAAIILGIVFEKQNVAFMVSLAFALAASGNFPVLVMSLLWKGCTTKGAAWGGAIGLLAAFG 481
Cdd:PRK09395 397 KATERDELRVSKITTLVLGVVAIILGILFEKQNIAFMVGLAFAIAASANFPVLLLSMYWKGLTTRGAVIGGWLGLISAVV 476
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 695172230 482 LTLVSPVIWVAVFGFERAIFPYSSPALFSVPAGFLAIWLISTLDRSPRAAIDRAGYPNQRLRSETGIGVHESVSH 556
Cdd:PRK09395 477 LMILSPTVWVDILGHEKAIFPYEYPALFSMPLAFVGIWFFSITDNSARAKREREAFRAQFVRSQTGIGASGASAH 551
|
|
| PRK12488 |
PRK12488 |
cation/acetate symporter; |
1-556 |
0e+00 |
|
cation/acetate symporter;
Pssm-ID: 237114 [Multi-domain] Cd Length: 549 Bit Score: 664.58 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 1 MTLLGWTSGANAAIAGAVQRQPTNWTAILMFGAFVGITLWITGAAARRTRTVSDFYT-GGGITGFQNGLAMAGDYCSAAS 79
Cdd:PRK12488 8 ALLLHSGALLASPALDAGQRQPLNWTAIGMFMVFVLFTLGITRWAARRTRSASDFYTaGGGLTGMQNGLAIAGDMISAAS 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 80 FLGITSQIFNDGYDGLIYAIGFLVGWPIVLFLIAEKLRNLGRFTFADVASYRFLQGPVRSFSAISTLLVVSFYLIAQMVG 159
Cdd:PRK12488 88 FLGISAMMFMNGYDGLLYALGVLAGWPIILFLIAERLRNLGKYTFADVVSYRLAQGPVRLTAAFGTLTVVLMYLVAQMVG 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 160 AGQLVQLLFGLPYLYAIVVVGGLMMVYVLFGGMRATSWVQIIKAVMLLCGATFLVLGVMAHVGFSFEALFARAVAVKtkl 239
Cdd:PRK12488 168 AGKLIELLFGISYLYAVVIVGALMVLYVTFGGMLATTWVQIIKAVLLLSGTSFMAFMVLKHFGFSTEAMFASAVAVH--- 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 240 aldsglapgdaaAKGRAIMGPGGFIKDPISALSFGFALMLGTAGLPHILMRFFTVPDAREARKSIMWATVWIGYFYALTF 319
Cdd:PRK12488 245 ------------AKGQAILAPGGLLSNPIDAISLGLGMMFGTAGLPHILMRFFTVSDAREARKSVLYATGFIGYFYLLII 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 320 VLGFGAIVMISFNPDYVDAAGALRGGNNMAVMHLAHAIGGNLFLGFISAVAFATILAVVAGLTLSAASAISHDVYASVIR 399
Cdd:PRK12488 313 VVGFGAIVMVGTEPSYRDAGGKIIGGGNMVAVHLAQAVGGNLFLGFISAVAFATILAVVAGLALSGASAVSHDLYACVIR 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 400 KGDADPGKELRVSRITTILLGIAAIILGIVFEKQNVAFMVSLAFALAASGNFPVLVMSLLWKGCTTKGAAWGGAIGLLAA 479
Cdd:PRK12488 393 KGQASEAQEMRVSKIATLGIGLLAVVLGLMFESQNIAFLSGLVLAIAASVNFPVLFLSMFWKGLTTRGAVAGSYAGLVSA 472
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 695172230 480 FGLTLVSPVIWVAVFGFERAIFPYSSPALFSVPAGFLAIWLISTLDRSPRAAIDRAGYPNQRLRSETGIGVHESVSH 556
Cdd:PRK12488 473 VVLVVLGPAVWVNVLHNATALFPYSNPALFSMSLAFLSAWVFSVTDRSERAVAERGRYLAQFVRSMTGIGAAGASKH 549
|
|
| ActP |
COG4147 |
Na+(or H+)/acetate symporter ActP [Energy production and conversion]; |
15-554 |
0e+00 |
|
Na+(or H+)/acetate symporter ActP [Energy production and conversion];
Pssm-ID: 443318 Cd Length: 526 Bit Score: 655.30 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 15 AGAVQRQPTNWTAILMFGAFVGITLWITGAAARRTRTVSDFYT-GGGITGFQNGLAMAGDYCSAASFLGITSQIFNDGYD 93
Cdd:COG4147 2 LALLEQLGMNLLAIGIFLVFVTFTLYITIWAARRTKSTSDFYVaGRGVTGVQNGLAIAGDYMSAASFLGIAGLIALSGYD 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 94 GLIYAIGFLVGWPIVLFLIAEKLRNLGRFTFADVASYRFLQGPVRSFSAISTLLVVSFYLIAQMVGAGQLVQLLFGLPYL 173
Cdd:COG4147 82 GLIYSIGWLVGYVLLLLLLAEYLRNFGKFTVPDFLGDRFYSRPARLVAAISTLVVSFFYLIAQMVGAGVLISLLLGVDYE 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 174 YAIVVVGGLMMVYVLFGGMRATSWVQIIKAVMLLCGATFLVLGVMAHVGFSFEALFARAVAVktklaldsglapgdaAAK 253
Cdd:COG4147 162 VAVVIVGVLMIVYVVLGGMKGTTWVQIIKAVLLIFAYTVPAVLVLAQFGFNPLPLLAKAAEV---------------HDL 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 254 GRAIMGPGGFIKDPISALSFGFALMLGTAGLPHILMRFFTVPDAREARKSIMWATVWIGYFYALTFVLGFGAIVMISFNP 333
Cdd:COG4147 227 GAAYLEPGGLVKSPLDFISLGLALMLGTAGLPHILMRFFTVPDAKEARKSVGWALGFIGLFYLTAPALGFGARALVGPLP 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 334 DYVDA--AGALRGGNNMAVMHLAHAI-GGNLFLGFISAVAFATILAVVAGLTLSAASAISHDVYASVIrKGDADPGKELR 410
Cdd:COG4147 307 EWFDTglIGAADGGGNMAVLALAEIAgGGNWLLGLVAAGAFATILAVVAGLLLAIASAISHDLYANVI-KGKATEKEELR 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 411 VSRITTILLGIAAIILGIVFEKQNVAFMVSLAFALAASGNFPVLVMSLLWKGCTTKGAAWGGAIGLLAAFGLTLVSPVIW 490
Cdd:COG4147 386 VARIAAVVIGVVAILLGINAPPQNVAFLVALAFALAASANFPVLLLSIFWKRFNTRGAVAGMLVGLISALVLIVLSPFVW 465
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 695172230 491 vaVFGFERAIFPYSSPALFSVPAGFLAIWLISTLDRSPrAAIDRAGYPNQRLRSETGIGVHESV 554
Cdd:COG4147 466 --VLGVDAALFPLENPGLVSMPLGFLVAIVVSLLTPEP-PAEDQELVEEQEVRSPTGIGAAKAS 526
|
|
| SLC5sbd_u4 |
cd11480 |
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
28-524 |
0e+00 |
|
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271374 Cd Length: 488 Bit Score: 529.00 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 28 ILMFGAFVGITLWITGAAARRTRTVSDFYT-GGGITGFQNGLAMAGDYCSAASFLGITSQIFNDGYDGLIYAIGFLVGWP 106
Cdd:cd11480 1 IGLFFVFVTITLYITIWAARRTRSTSDFYVaGRGVPPVQNGLAIAGDYMSAASFLGIAGLIALSGYDGLAYAIGWTGGYV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 107 IVLFLIAEKLRNLGRFTFADVASYRFLQGPVRSFSAISTLLVVSFYLIAQMVGAGQLVQLLFGLPYLYAIVVVGGLMMVY 186
Cdd:cd11480 81 LLLLLVAEPLRNFGKYTVPDFLGARLGSRPVRLVAAVSTLVISFFYLVAQMVGAGLLLSLLLGIPYEVGVVVVGALMIVY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 187 VLFGGMRATSWVQIIKAVMLLCGATFLVLGVMAHVGFSFEALfaravavktkLALDSGLAPGDAAAKGRAIMGPGGFIKD 266
Cdd:cd11480 161 VVLGGMRATTWVQIIQYVLLLGAFLVPAILVLARFGGNPLGA----------GPGLLGLAAAAASGAGEAYLAPGLLLTD 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 267 PISALSFGFALMLGTAGLPHILMRFFTVPDAREARKSIMWATVWIGYFYALTFVLGFGAIVMISFNPDYVDAAGALRGGN 346
Cdd:cd11480 231 PLDVISLTLALMLGTAGLPHVLMRFYTVPDARAARKSVVWALGFIGLFYLLAPALGFGARALVGPDVIGAPIAGELDGGG 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 347 NMAVMHLAHAIG-GNLFLGFISAVAFATILAVVAGLTLSAASAISHDVYASVIRKGdADPGKELRVSRITTILLGIAAII 425
Cdd:cd11480 311 DMAVLLLPEIAGlGDLLLALVAAGAFAAILATVAGLLLAAASALAHDLYAGVIRPG-ASERREVRVARIAAVVVGVIAIL 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 426 LGIVFEKQNVAFMVSLAFALAASGNFPVLVMSLLWKGCTTKGAAWGGAIGLLAAFGLTLVSPVIWVAVFGFERAIFPYSS 505
Cdd:cd11480 390 LALLFPPQNVAFLVALAFAIAASAFFPVLVLGIFWRRFTTRGAIAGMLVGLLVSLVLIVLSPAVSGAPPGHDFAGFPLTN 469
|
490
....*....|....*....
gi 695172230 506 PALFSVPAGFLAIWLISTL 524
Cdd:cd11480 470 PGLVSVPLGFLVAIVVSLL 488
|
|
| SSF |
pfam00474 |
Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite ... |
55-475 |
5.05e-103 |
|
Sodium:solute symporter family; This family includes Swiss:P33413 which is not in the Prosite entry. Membership of this family is supported by a significant blast score.
Pssm-ID: 109527 [Multi-domain] Cd Length: 406 Bit Score: 316.20 E-value: 5.05e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 55 FYTGGG-ITGFQNGLAMAGDYCSAASFLGITSQIFNDGYDGLIYAIGFLVGWPIVLFLIAEKLRNLGRFTFADVASYRFL 133
Cdd:pfam00474 1 YFLAGRsMTGFVNGLSLAASYMSAASFVGLAGAGAASGLAGGLYAIGALVGVWLLLWLFAPRLRNLGAYTMPDYLRKRFG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 134 QGPV-RSFSAISTLLVVSFYLIAQMVGAGQLVQLLFGLPYLYAIVVVGGLMMVYVLFGGMRATSWVQIIKAVMLLCGATF 212
Cdd:pfam00474 81 GKRIlVYLSALSLLLYFFTYMSVQIVGGARLIELALGLNYYTAVLLLGALTAIYTFFGGFLAVSWTDTIQAVLMLFGTII 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 213 LVLGVMAHVGfSFEALFARAVAvktklaldsglapgdAAAKGRAIMGPGGF--IKDPISALSFGFALMLGTAGLPHILMR 290
Cdd:pfam00474 161 LMIIVFHEVG-GYSSAVEKYMT---------------ADPNGVDLYTPDGLhiLRDPLTGLSLWPGLVLGTTGLPHILQR 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 291 FFTVPDAREARKSIMWATVWIGYFYALTFVLGFGAIVMISFNPDyvdAAGALRGGNNMAVMHLAHAIGGNLFLGFISAVA 370
Cdd:pfam00474 225 CLAAKDAKCIRCGVLILTPMFIIVMPGMISRGLFAIALAGANPR---ACGTVVGCSNIAYPTLAVKLGPPGLAGIMLAVM 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 371 FATILAVVAGLTLSAASAISHDVYASVIRKGDADPGKELRVSRITTILLGIAAIILGIVFEKQNVAFMVSLAFALAASGN 450
Cdd:pfam00474 302 LAAIMSTLTSQLLSSSSAFTHDLYKNIRRKASATEKELVGRSRIIVLVVISLAILLAVQPAQMGIAFLVQLAFAGLGSAF 381
|
410 420
....*....|....*....|....*
gi 695172230 451 FPVLVMSLLWKGCTTKGAAWGGAIG 475
Cdd:pfam00474 382 LPVILLAIFWKRVNEQGALWGMIIG 406
|
|
| Na_symport_lg |
TIGR03648 |
probable sodium:solute symporter, VC_2705 subfamily; This family belongs to a larger family of ... |
28-532 |
1.05e-63 |
|
probable sodium:solute symporter, VC_2705 subfamily; This family belongs to a larger family of transporters of the sodium:solute symporter superfamily, TC 2.A.21. Members of this strictly bacterial protein subfamily are found almost invariably immediately downstream from a member of family TIGR03647. Occasionally, the two genes are fused.
Pssm-ID: 274698 Cd Length: 552 Bit Score: 217.89 E-value: 1.05e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 28 ILMFGAFVGITLWitgaaaRRTRTVSDFY-TGGGITGFQNGLAMAGDYCSAASFLGITSQIFNDGYDGLIYAIGFLVGWP 106
Cdd:TIGR03648 6 GATFALYIGIGIW------SRAGSTSEFYvAGRGVPPVANGMATAADWMSAASFISMAGLIAFLGYDGLAYLMGWTGGYV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 107 IVLFLIAEKLRNLGRFTFADVASYRFLQGPVRSFSAISTLLVVSFYLIAQMVGAGQLVQLLFGLPYLYAIVVVGGLMMVY 186
Cdd:TIGR03648 80 LLALLLAPYLRKFGKYTVPDFIGDRYYSNTARLVAVICAIFISFTYVAGQMRGVGVVFSRFLEVDFETGVFIGMAIVFFY 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 187 VLFGGMRATSWVQIIKAVML----LCGATFLVL----GVMAHVGF----SFEALFARAVAVKTKLALDSGLAPGDAaakg 254
Cdd:TIGR03648 160 AVLGGMKGVTWTQVAQYIVLivayLVPAIFISLkltgNPVPQLGYgsalSGVYLLDKLDELEVDLGFAEYTEPFGS---- 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 255 raimgpggfiKDPISALSFGFALMLGTAGLPHILMRFFTVPDAREARKSIMWATVWIGYFY-------------ALTFVL 321
Cdd:TIGR03648 236 ----------KSRINVFALTLALMVGTAGLPHVIVRFYTVPKVRDARWSAGWALFFIALLYttapavaafarynLITTVN 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 322 G---------------FGAIVMISFNPD-----YVDAAGALRGGNNMAVMhLAHAIGG--NLFLGFISAVAFATILAVVA 379
Cdd:TIGR03648 306 GtpyaelpgwvanwekTGLLKFEDKNGDgilqySGDAGNELTIDRDIIVL-ATPEIAGlpYWVIGLVAAGGLAAALSTAA 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 380 GLTLSAASAISHDVYASVIRKgDADPGKELRVSRITTILLGIAAIILGIvFEKQNVAFMVSLAFALAASGNFPVLVMSLL 459
Cdd:TIGR03648 385 GLLLVISSAISHDLYYRIINP-NASEKQRLLVARIALVVAAVIAGYFGL-NPPGFIAQVVAFAFGLAAASFFPALVLGIF 462
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 460 WKGCTTKGAawggAIGLLAAFGLTLvSPVIWVAVFGFERAIFPYSSPA------------LFSVPAGFLAIWLISTLDRS 527
Cdd:TIGR03648 463 WKRMNREGA----IAGMLTGLGFTF-SYIVYFKPWGFIGTNPGANVPEnwwfgispegigLIGMPVNFAVAIVVSLVTPP 537
|
....*
gi 695172230 528 PRAAI 532
Cdd:TIGR03648 538 PPQEI 542
|
|
| PutP |
COG0591 |
Na+/proline symporter [Amino acid transport and metabolism]; |
24-535 |
5.74e-63 |
|
Na+/proline symporter [Amino acid transport and metabolism];
Pssm-ID: 440356 [Multi-domain] Cd Length: 476 Bit Score: 213.91 E-value: 5.74e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 24 NWTAILMFGAFVGITLWITGAAARRTRTVSDFYTGGG-ITGFQNGLAMAGDYCSAASFLGITSQIFNDGYDGLIYAIGFL 102
Cdd:COG0591 2 STLDLIIIILYLLLLLGIGLYASRRTKSLEDYFLAGRsLGWWVLALSLGATWLSAWTFLGVPGLAYAYGLSALWYALGYA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 103 VGWPIVLFLIAEKLRNLGRFTFADVASYRFlQGPVRSFSAISTLLVVSFYLIAQMVGAGQLVQLLFGLPYLYAIVVVGGL 182
Cdd:COG0591 82 LGALLLALFFAPRLRRLGALTIPEFLEKRF-GRGLRLLAAIIILLFLLGYLAAQLVALGKLLEALFGIPYWLGILIGALI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 183 MMVYVLFGGMRATSWVQIIKAVMLLCGATFLVLGVMAHVGfSFEALFARavavktklaldsglapgdAAAKGRAIMGPGG 262
Cdd:COG0591 161 VLLYTVLGGLRAVAWTDVLQGILMLVGLILLLIVALSALG-GFGELFAA------------------LPAPGLLSLFPGL 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 263 FIKDPISALSFGFALMLGTAGLPHILMRFFTVPDAREARKSIMWATVWIGYFYALTFVLGFGAIVmisFNPDYVDAAGal 342
Cdd:COG0591 222 GFTGWLAFLGLFLAIGLGYFGQPHIVQRFLAAKSEKEARKAALIGGLLYLLFYLLAALIGLLARA---LFPDLPLADP-- 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 343 rggnNMAVMHLAHAIGGNLFLGFISAVAFATILAVVAGLTLSAASAISHDVYASVIRKgDADPGKELRVSRITTILLGIA 422
Cdd:COG0591 297 ----DLALPLLILELLPPGLAGLLLAAILAAAMSTADSQLLAASSVFTRDIYKPFIKP-KASDKQLLRVSRLAVLVVGLL 371
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 423 AIILGIVFeKQNVAFMVSLAFALAASGNFPVLVMSLLWKGCTTKGAAWGGAIGLLAafgltlvspVIWVAVFGFERAIFP 502
Cdd:COG0591 372 ALLLALLF-PSSILDLVLLAWGGLGAALLPPLLLGLFWKRATKAGALAGMIAGLVV---------VLLWKLLGGPLGPFG 441
|
490 500 510
....*....|....*....|....*....|...
gi 695172230 503 YSSPALFSVPAGFLAIWLISTLDRSPRAAIDRA 535
Cdd:COG0591 442 WLYPILPGLLVSLLVFVVVSLLTKPPSEEVLEE 474
|
|
| SLC5sbd_PutP |
cd11475 |
Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Escherichia coli ... |
26-524 |
9.41e-55 |
|
Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Escherichia coli PutP catalyzes the Na+-coupled uptake of proline with a stoichiometry of 1:1. The putP gene is part of the put operon; this operon in addition encodes a proline dehydrogenase, allowing the use of proline as a source of nitrogen and/or carbon. This subfamily also includes the Bacillus subtilis Na+/proline cotransporter (OpuE) which has an osmoprotective instead of catabolic role. Expression of the opuE gene is under osmotic control and different sigma factors contribute to its regulation; it is also a putative CcpA-activated gene. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271369 Cd Length: 464 Bit Score: 191.57 E-value: 9.41e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 26 TAILMFGAFVGITLWitgaAARRTRTVSDFYTGG-GITGFQNGLAMAGDYCSAASFLGITSQIFNDGYDGLIYAIGFLVG 104
Cdd:cd11475 3 TFIVYLLLMLGIGIY----SYRKTKTLEDYFLGGrSLGPWVTALSAGASDMSGWLLLGLPGAAYASGLSAIWIAIGLILG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 105 WPIVLFLIAEKLRNL----GRFTFADVASYRFLQ--GPVRSFSAISTLLVVSFYLIAQMVGAGQLVQLLFGLPYLYAIVV 178
Cdd:cd11475 79 AYLNWLFVAKRLRRYteknDSITLPDYLENRFRDksKLLRILSALIILIFFTIYAAAQLVAGGKLFESLFGIDYSTGLLI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 179 VGGLMMVYVLFGGMRATSWVQIIKAVMLLCGATFLVLGVMAHVGfSFEALFARAVAVKTKLaldsglapgDAAAKGRAIM 258
Cdd:cd11475 159 GAVVVVAYTFLGGFLAVSWTDFFQGLLMLLALVLVPIVALAALG-GLSGLVAALAAIDPGL---------LSPFGGDLGA 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 259 GPGGFIkdpISALSFGfalmLGTAGLPHILMRFFTVPDAREARKSIMWATVWIGYFYALTFVLGFGAIVMISfnpdyvda 338
Cdd:cd11475 229 GGLLAI---ISLLAWG----LGYFGQPHILVRFMAIRSPKEIKKARRIAMVWMILFLLGAVLVGLLGRALFP-------- 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 339 aGALRGGNNMAVMHLAHAIGGNLFLGFISAVAFATILAVVAGLTLSAASAISHDVYASVIRKgDADPGKELRVSRITTIL 418
Cdd:cd11475 294 -DGLLGDPETVFPVLAQELFPPWLAGILLAAILAAIMSTADSQLLVCSSALTEDLYKAFLRK-EASDKELVWVSRLAVLV 371
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 419 LGIAAIILGIvFEKQNVAFMVSLAFALAASGNFPVLVMSLLWKGCTTKGAAWGGAIGLLAAfgltlvspVIWVAVFGFER 498
Cdd:cd11475 372 IALIALLIAL-NPPSSVFSLVSFAWAGLGAAFGPLLLLSLYWKRTTRQGALAGMIAGAVTV--------VVWKLLGLGIF 442
|
490 500
....*....|....*....|....*.
gi 695172230 499 AIFPYSSPALFSvpagFLAIWLISTL 524
Cdd:cd11475 443 GLYEIVPGFLAS----LLAIVVVSLL 464
|
|
| SLC5sbd |
cd10322 |
Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding ... |
28-522 |
3.98e-51 |
|
Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; This family represents the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporter family or solute sodium symporter family) that co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. Family members include: the human glucose (SGLT1, 2, 4, 5), chiro-inositol (SGLT5), myo-inositol (SMIT), choline (CHT), iodide (NIS), multivitamin (SMVT), and monocarboxylate (SMCT) cotransporters, as well as Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). One member of this family, human SGLT3, has been characterized as a glucose sensor and not a transporter. Members of this family are important in human physiology and disease.
Pssm-ID: 271357 [Multi-domain] Cd Length: 454 Bit Score: 181.60 E-value: 3.98e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 28 ILMFGAFVGITLWITGAAARRTRTVSDFYTGG-GITGFQNGLAMAGDYCSAASFLGITSQIFNDGYDGLIYAIGFLVGWP 106
Cdd:cd10322 3 LIIVVVYLALLLGIGLYASKKVKSSEDFFLAGrSLGPWLLAGTLAATWISAGSFVGVAGLAYTYGLSAIWYILGAALGAL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 107 IVLFLIAEKLRNLGRFTFADVASYRFLQGPVRSFSAISTLLVVSFYLIAQMVGAGQLVQLLFGLPYLYAIVVVGGLMMVY 186
Cdd:cd10322 83 LLALFLAPRLRRLGKTTIPETILERYYSKGLRLLVAIIIIIALIPYLALQLIGGGYILSTLLGIPYTVAVIIAAVIVILY 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 187 VLFGGMRATSWVQIIKAVMLLCGATFLVLGVMAHVG-FSFEALFARAVAVKTKLALDSGLApgdaaakgraimgpggfik 265
Cdd:cd10322 163 TVFGGMRAVAWTDVIQGIVMLIGVLVAAIFILSKVGgGGFSALAAALPALLLALGPGGGLG------------------- 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 266 dPISALSFGFALMLGTAGLPHILMRFFTVPDAREARKSIMWATVWIGYFYALTFVLGFGAIVMisfNPDYVDAagalrgg 345
Cdd:cd10322 224 -WSTILSLILLTGLGVLALPQVFQRILAAKDEKTARRAFLLAGLLLLLIGFLVALIGLAARAL---FPDLENP------- 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 346 nNMAVMHLAHAIGGNLFLGFISAVAFATILAVVAGLTLSAASAISHDVYASVIRKgDADPGKELRVSRITTILLGIAAII 425
Cdd:cd10322 293 -DLALPTLINSLLPPGLAGLVLAGLLAAAMSTADSLLLAASTLFTRDIYKPLINP-KASDKKLLRVSRIAVVVVGVLALL 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 426 LGIVFekQNVAFMVSLAFALAASGNFPVLVMSLLWKGCTTKGAAWGGAIGLLAAFGLTLVSPVIWVAVFgferaifpyss 505
Cdd:cd10322 371 LALLP--PSILLLLSLAAGLLAAALFPPLLGGLFWKRATKAGAIAGIIVGLIVTLVWLLLPLASPLGID----------- 437
|
490
....*....|....*..
gi 695172230 506 PALFSVPAGFLAIWLIS 522
Cdd:cd10322 438 PIIPALLVSLIVFVVVS 454
|
|
| sss |
TIGR00813 |
transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the ... |
58-475 |
5.74e-46 |
|
transporter, SSS family; The Solute:Sodium Symporter (SSS) Family (TC 2.A.21) Members of the SSS family catalyze solute:Na+ symport. The solutes transported may be sugars, amino acids, nucleosides, inositols, vitamins, urea or anions, depending on the system. Members of the SSS family have been identified in bacteria, archaea and animals, and all functionally well characterized members catalyze solute uptake via Na+ symport. Proteins of the SSS generally share a core of 13 TMSs, but different members of the family may have different numbers of TMSs. A 13 TMS topology with a periplasmic N-terminus and a cytoplasmic C-terminus has been experimentally determined for the proline:Na+ symporter, PutP, of E. coli. [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273282 [Multi-domain] Cd Length: 407 Bit Score: 166.32 E-value: 5.74e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 58 GGGITGFQNGLAMAGDYCSAASFLGITSQIFNDGYDGLIYAIGFLVGWPIVLFLIAEKLRNLGRFTFADVASYRFLQGPV 137
Cdd:TIGR00813 2 GRSLGGWVVAASLFASYISASQFLGLPGAIYAYGFAIGFYELGALVLLIILGWLFVPIFINNGAYTMPEYLEKRFGKRIL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 138 RSFSAISTLLVVSFYLIAQMVGAGQLVQLLFGLPYLYAIVVVGGLMMVYVLFGGMRATSWVQIIKAVMLLCGATFLVLGV 217
Cdd:TIGR00813 82 RGLSVLSLILYIFLYMSVDLFSGALLIELITGLDLYLSLLLLGAITILYTVFGGLKAVVWTDTIQAVIMILGTFILPVFA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 218 MAHVGFsFEALFARAvavktklaldSGLAPGDAAAKGRAIMGPGGFIKD-PISALSFGFALMLGTAGLPH-ILMRFFTVP 295
Cdd:TIGR00813 162 FSEVGG-LGTFVEKA----------SQAAPTNPSPDDLYDFFRDPSTSDlPWGAGVFGLPHVALWYWTNQvIVQRCLAAK 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 296 DAREARKSIMWATVWIGYFYALTFVLGFGAIVMisFNPDYVDAAGALRGGNNMAVMHLAHAIGGNLFLGFISAVAFATIL 375
Cdd:TIGR00813 231 SAKHAKKGCLISGVLKLLPMFGAVLPGLIARAL--YTDIDPALAGAVNQNSDQAYPLLVQELMPPGLAGLFLAAILAAVM 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 376 AVVAGLTLSAASAISHDVYASVIRKgdADPGKELRVSRITTILLGIAAIILGIVFEK-QNVAFMVSLAFALAASGNFPVL 454
Cdd:TIGR00813 309 STLSSQLNSASTVFTMDLYKKIIRP--NASGEKKIVMRGRIAVLVAAVIAGFVAAAQgGQVLQYVQEAFGGLGAPFLPVF 386
|
410 420
....*....|....*....|.
gi 695172230 455 VMSLLWKGCTTKGAAWGGAIG 475
Cdd:TIGR00813 387 LLGIFWKRMNAKGALAGMIAG 407
|
|
| SLC5sbd_PanF |
cd10327 |
Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute ... |
27-490 |
1.00e-25 |
|
Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; PanF catalyzes the Na+-coupled uptake of extracellular pantothenate for coenzyme A biosynthesis in cells. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 212037 Cd Length: 472 Bit Score: 110.37 E-value: 1.00e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 27 AILMFGAFVGITLWITGAAARRTRT-VSDFYTGG-GITGFQNGLAMAGDYCSAASFLGITSQIFNDGYD-GLIYAIGFLV 103
Cdd:cd10327 5 IIIYLVILLGIGFYARRSKKRRSGDfLEEYFIGGrSMGGFVLAMTLVATYTSASSFIGGPGAAYKIGLGwVLLAMIQVPT 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 104 GWpIVLFLIAEKLRNLGR----FTFADVASYRFLQGPVRSFSAISTLLVVSFYLIAQMVGAGQLVQLLFGLPYLYAIVVV 179
Cdd:cd10327 85 GF-LTLGVLGKKFAIIARkinaVTIIDYLRARYNSKALVVLSSLALIVFFIAAMVAQFIGGARLLEAVTGLSYVTGLLIF 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 180 GGLMMVYVLFGGMRATSWVQIIKAVMLLCGATFLVLGVMAHVGfSFEALFARAVAVKTKLaldsglapgdaaakgraIMG 259
Cdd:cd10327 164 GLTVILYTTIGGFRAVALTDAIQGIVMIIGTVLLLVGVLAAGG-GMEAIMATLAEIDPNL-----------------LTP 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 260 PGGFIKDPISALSFGFALMLGTAGLPHILMRFFTVPDAREARKSIMWATVWIGYFYALTFVLGFGAIVMISfNPDYVDaa 339
Cdd:cd10327 226 FGPGFLSPPYILSFWVLVGFGVIGLPQTAVRCMGYKDSKSMHRAMIIGTVVVGFLMLGMHLAGVLGRAVLP-DLEVPD-- 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 340 galrggnnMAVMHLAHAIGGNLFLGFISAVAFATILAVVAGLTLSAASAISHDVYASVIRKG-DADPGKELRVSRITTIL 418
Cdd:cd10327 303 --------KVIPTLALKVLPPWLAGLFLAGPLAAIMSTVDSQLILASSAIVKDLYLNYKNKEkKTSEKKVKRISLIITII 374
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 695172230 419 LGIAAIILGIvfEKQNVAFMVSL-AFALAASGNFPVLVMSLLWKGCTTKGAAWGGAIGLLAAFGLTLVSPVIW 490
Cdd:cd10327 375 LGLLVFLLAI--NPPDLIVWLNLfAFGGLEAAFFWPLVLGLYWKRANATGALASMVVGLVSYILITYLKIKIL 445
|
|
| SLC5sbd_u1 |
cd11477 |
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
25-524 |
7.78e-24 |
|
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271371 Cd Length: 493 Bit Score: 104.97 E-value: 7.78e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 25 WTAILMFGAF-VGITLWitgAAARRTRTVSDFYTGGG-ITGFQNGLAMAGDYCSAASFLGITSQIFNDGYDGLIYAIGFL 102
Cdd:cd11477 3 WLVIALYFLLmLGIGLW---FSKRASKSTSDFFLGGRkLPWWLAGISMAATTFSADTFVAVAGIAYTYGIAGNWIWWLWA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 103 VGWPIVLFLIAEKLRNLGRFTfaDVASY-RFLQG----PVRSFSAISTLLVVSFYLIAQ-MVGAGQLVQLLFGLPYLYAI 176
Cdd:cd11477 80 VAGLIGAFVFARRWRRLRVLT--DGEFPeERYGGrygaPLRQFYAVYFALLSNVDILAWvFLAAIKVSAVFGPWDPWLTI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 177 VVVGGLMMVYVLFGGMRATSWVQIIKAVMLLCGATFLVLGVMAHVGfSFEALFARavavktklaldsglAPGDAAAKGRA 256
Cdd:cd11477 158 LILGLITLIYTVIGGLWAVVVTDVVQFVIAMAASIAVAVLALNAVG-GPGGLFAQ--------------LPEGHLDLFGS 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 257 IMGPGGFIKDPISALSFGFALMLGTAGLPHILMRFFTVPDAREARKSIMWATVWIGYFYALTFVLGFGAIVMISFNPDyv 336
Cdd:cd11477 223 GLGASGFYITFFFILFFGWYPLSYSGGGWYLAQRYLSAKSEKAAKAAAWLFAALYLVRPWPWMLPALAALVLYPDLDD-- 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 337 DAAGALRGGNNMAVMHLAHAIGGNLFLGFISAVA--FATILAVvagltlsAASAISHDVYASVIRKgDADPGKELRVSRI 414
Cdd:cd11477 301 PEADFELAYPMMIKEYLPAGLLGLVLAGLLAATMstVSTHLNW-------GAAYLVNDIYKRFIKP-NASEKHLLKVGRL 372
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 415 TTILLGIAAIILGIVFEKQNVAFMVSLAFalaASGNFPVLVMSLLWKGCTTKGAAWGGAIGLLAAFGLTLVSPVIwvavf 494
Cdd:cd11477 373 ATVLFGLLSIVVALASDSIGGAFWIVLAL---GAGLGGPLILPWLWWRFNAWTEIWAMIASIIVGLVVSVLLKVF----- 444
|
490 500 510
....*....|....*....|....*....|.
gi 695172230 495 gferaIFPYSSPALFSVPAGF-LAIWLISTL 524
Cdd:cd11477 445 -----GLPEDFLFSFLVPVLLsLVVWLAVTL 470
|
|
| SLC5sbd_u3 |
cd11479 |
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
28-490 |
3.76e-20 |
|
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271373 Cd Length: 454 Bit Score: 93.44 E-value: 3.76e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 28 ILMFGAFVGITLWitgaAARRTRTVSDFYTGGGITGFqnGLAMAgdyCSAASFLGITSQIfndGYDGLIYAIG------- 100
Cdd:cd11479 7 ALYFAAMIAIGWW----GMRRAKTSEDYLVAGRRLGP--GLYLG---TMAAVVLGGASTI---GGVGLGYQYGisgmwlv 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 101 FLVGWPIVL--FLIAEKLRNLGRFTFADVASYRFlQGPVRSFSAISTLLVVSFYLIAQMVGAGQLVQLLFGLPYLYAIVV 178
Cdd:cd11479 75 VAIGLGILAlsLLLAKRIARLKVYTVSEVLELRY-GPSARVISALVMLAYTLMVAVTSTIAIGTVFSVLFGLPRTLSILV 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 179 VGGLMMVYVLFGGMRATSWVQIIKAVMLLCGATFLVLGVMAHVGFSFEALFARAVAvktklaldsglapgdaaakgrAIM 258
Cdd:cd11479 154 GGGIVVLYSVLGGMWSITLTDIIQFVIKTIGIFLLLLPLALSKAGGLSGLQEKLPA---------------------SYF 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 259 GPGGFIKDPISA--LSFGFALMLGTaglpHILMRFFTVPDAREARKSIMWATVWIGYFYALTFVLGFGAIVMIsfnPDYV 336
Cdd:cd11479 213 DLTSIGWDTIVTyfLLYFFGILIGQ----DIWQRVFTARSEKVARWGGVAAGLYCVLYGVAGALIGMAAAVLL---PDLA 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 337 DAAGALRggnNMAVMHLAHAIggnlfLGFISAVAFATILAVVAGLTLSAASAISHDVYASVIRKgDADPGKELRVSRITT 416
Cdd:cd11479 286 NPQNAFA---TMAQEVLPVGL-----RGLVLAAALAAMMSTASGALLASSTVLTNDVLPRLRRK-NESERSEVRLSRLFT 356
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 417 ILLGIAAIILGIVFekQNVAFMVSLAFALAASGNFPVLVMSLLWKGCTTKGAAWG------GAIGLLAAFGLTLVSPVIW 490
Cdd:cd11479 357 LLLGVVVIVIAVLV--NDVVAALTIAYAILVGGLLVPILGGLFWKRATGAGALASmvagsvVVLAGMAVDGLLANTPIYY 434
|
|
| PRK15419 |
PRK15419 |
sodium/proline symporter PutP; |
45-534 |
3.42e-17 |
|
sodium/proline symporter PutP;
Pssm-ID: 185317 Cd Length: 502 Bit Score: 84.30 E-value: 3.42e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 45 AARRTRTVSDFYTGGGITG-FQNGLAMAGDYCSAASFLGITSQIFNDGYDGLIYAIGFLVGWPIVLFLIAEKLR-----N 118
Cdd:PRK15419 25 AWRSTKNFDDYILGGRSLGpFVTALSAGASDMSGWLLMGLPGAVFLSGISESWIAIGLTLGAWINWKLVAGRLRvhteyN 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 119 LGRFTFADVASYRFLQGP--VRSFSAISTLLVVSFYLIAQMVGAGQLVQLLFGLPYLYAIVVVGGLMMVYVLFGGMRATS 196
Cdd:PRK15419 105 NNALTLPDYFTGRFEDKSriLRIISALVILLFFTIYCASGIVAGARLFESTFGMSYETALWAGAAATILYTFIGGFLAVS 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 197 WVQIIKAVMLLCGATFLVLGVMAHVGFSFEALfaraVAVKTKLALDSGLAPGDAAAKGRAIMGPGgfikdpisalsfgfa 276
Cdd:PRK15419 185 WTDTVQASLMIFALILTPVIVIISVGGFGDSL----EVIKQKSIENVDMLKGLNFVAIISLMGWG--------------- 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 277 lmLGTAGLPHILMRFFTVPDAREARKSIMWATVWIGYFYALTFVLGFGAIVMISFNPdyvDAAGALRGGNNMAVMHLAHA 356
Cdd:PRK15419 246 --LGYFGQPHILARFMAADSHHSIVHARRISMTWMILCLAGAVAVGFFGIAYFNEHP---AVAGAVNQNAERVFIELAQI 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 357 IGGNLFLGFISAVAFATILAVVAGLTLSAASAISHDVYASVIRKGdADPGKELRVSRITTILLGIAAIILGIVFEKQnVA 436
Cdd:PRK15419 321 LFNPWIAGILLSAILAAVMSTLSCQLLVCSSAITEDLYKAFLRKH-ASQKELVWVGRVMVLVVALVAIALAANPENR-VL 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 437 FMVSLAFALAASGNFPVLVMSLLWKGCTTKGAAWGGAIGllaafgltLVSPVIWVAvfgferaifpYSSPALFSVPAGF- 515
Cdd:PRK15419 399 GLVSYAWAGFGAAFGPVVLFSVMWSRMTRNGALAGMIIG--------ALTVIVWKQ----------FGWLGLYEIIPGFi 460
|
490 500
....*....|....*....|..
gi 695172230 516 ---LAIWLISTLDRSPRAAIDR 534
Cdd:PRK15419 461 fgsIGIVVFSLLGKAPSAAMQK 482
|
|
| SLC5sbd_DUR3 |
cd11476 |
Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Dur3 is ... |
28-486 |
3.79e-17 |
|
Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain; Dur3 is the yeast plasma membrane urea transporter. Saccharomyces cerevisiae DUR3 also transports polyamine. The polyamine uptake of S. cerevisiae DUR3 is activated upon its phosphorylation by polyamine transport protein kinase 2 (PTK2). S. cerevisiae DUR3 also appears to play a role in regulating the cellular boron concentration. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271370 Cd Length: 493 Bit Score: 84.18 E-value: 3.79e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 28 ILMFGAFVGITLWITGAAARRTRTVSDFYTGGGITGFqnGLAMAGDYCS---AASFLGITSQIFNDGYDGLI-YAIGFLV 103
Cdd:cd11476 8 GALFALLMVFITRLLKRYRGKNQSSEEFMTAGRSVGT--GLTAAAIVSSwtwAATLLQSATVAYQYGVSGPFwYASGATL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 104 gwPIVLF-LIAEKLRNL--GRFTFADVASYRFLQGP--VRSFSAISTLLVVsfyLIAQMVGAGQLVQLLFGLPYLYAIVV 178
Cdd:cd11476 86 --QILLFaPLAIRIKRLapNAHTLLEIVRARYGTAAhlVFLVFALFTNVIV---LAMLLLGGSAVVNALTGMPIVAASFL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 179 VGGLMMVYVLFGGMRAT---SWVQIIkaVMLLCGATFLVLGVMAHVGFSFEALFARAVavktklaldsglapgdAAAKGR 255
Cdd:cd11476 161 IPLGVLLYTLFGGLRATfltDYIHTV--IILIILLVFAFAVYTSSDIGSPSKVYDLLQ----------------EAAPDL 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 256 AIMGPGGFIKDP--ISALSFGFALMLGTAGL----PHILMRFFTVPDAREARKSIMWATVWIGYFYALTFVLGFGAiVMI 329
Cdd:cd11476 223 PVEGNQGSYLTFksKAGLIFGIINIVGNFGTvfldQGYWQRAIAARPSAAVKGYFLGGLAWFAIPFLLATTLGLAA-LAL 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 330 SFNPDYVDaagalrGGNNMAVMHLAHAIGGNLFLGFISAVAFATILAVVAGLTLSAASAISHDVYASVIRKGdADPGKEL 409
Cdd:cd11476 302 GLNPTFEE------VSAGLVLPYVAAALLGKGGAAAVLVLLFMAVTSTASAELIAVSSIVTYDIYRTYINPN-ATGKQLL 374
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 695172230 410 RVSRITTILLGIAAIILGIVFEKQ--NVAFMVSLAFALAASGNFPVLVmSLLWKGCTTKGAAWGGAIGLLAAFGLTLVS 486
Cdd:cd11476 375 RVSRIAVIGFGLFMGGLAVGLNYIgiSLGWLLLFMGILIGSAVFPVAL-GLYWRRQTGTAAVVSPIAGLVAGLAVWLVT 452
|
|
| SLC5sbd_NIS-like_u2 |
cd11494 |
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ... |
33-496 |
5.93e-16 |
|
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters, SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271385 [Multi-domain] Cd Length: 473 Bit Score: 80.34 E-value: 5.93e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 33 AFVGITLWITgaaaRRTRTVSDFYTGGGITG-FQNGLAMAGDYCSAASFLGITSQIFNDGYDGLIYAIGFLVGWPIVLFL 111
Cdd:cd11494 12 GILVYGVYKG----RGQKNQEDYFLGGRSMPwWPIGLSIMATQASAITFLSAPGQAYSDGMRFVQYYFGLPLAMIFLCIT 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 112 IAEKLRNLGRFTfadvaSYRFLQgpvRSFSAISTLLVVSFYLIAQMVGAGQLV-------QLLFGLPYLYAIVVVGGLMM 184
Cdd:cd11494 88 FVPVFYKLKVYT-----AYEYLE---RRFGLKTRLLTSILFLISRGLATGVTIyapaiilSTILGWSLWLTILLIGGITI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 185 VYVLFGGMRATSWVQIIKAVMLLCGATFLVLGVMAHVGFSFEALFARAVAVKTKLALDSGLAPGDAAAKGRAIMGpggfi 264
Cdd:cd11494 160 IYTVLGGIKAVIWTDVIQMVIIWAGLFIAFGLLLKLLPVGFVDALLVAGKSGRLNALDFSFDLSDTYTFWSGLIG----- 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 265 kdpisalsfGFALMLGTAGLPH-ILMRFFTVPDAREARKSIMWATVWIGYFYALTFVLGFGAIVMISFNPDYVDAAGALR 343
Cdd:cd11494 235 ---------GFFLYLSYFGTDQsQVQRYLTAKSIKEARKSLLLNGFLKFPMQFFILLIGVLVFVFYQFNPFPVSFNPAED 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 344 GGN--NMAVMHLAHAIGGNLFLGFISAVAFATILAVVAGLTLSAASAISHDVYASVIRKgDADPGKELRVSRITTILLGI 421
Cdd:cd11494 306 ETKdtNYIFLRFVLNYLPPGVIGLLIAAIFAAAMSSIDSALNSLATVTVIDIYRRFFKK-DASDEHYLKVSRLLTVFWGL 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 422 AAI-------ILGIVFEKQNVafmVSLAFALAASGNFpvlVMSLLWKGCTTKGAAWGGAIGLLAAFGLTLVSPV--IWVA 492
Cdd:cd11494 385 LAIvfalfagLAGSLIEAVNK---LGSLFYGPILGVF---LLAFFTKKANGKGVFAGAILGVIVVIVLWLFPDVswLWWN 458
|
....
gi 695172230 493 VFGF 496
Cdd:cd11494 459 VIGC 462
|
|
| SLC5sbd_u2 |
cd11478 |
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 ... |
29-491 |
2.10e-12 |
|
Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; SLC5 (also called the sodium/glucose cotransporter family or solute sodium symporter family) is a family of proteins that co-transports Na+ with sugars, amino acids, inorganic ions or vitamins. Prokaryotic members of this family include Vibrio parahaemolyticus glucose/galactose (vSGLT), and Escherichia coli proline (PutP) and pantothenate (PutF) cotransporters. One member of the SLC5 family, human SGLT3, has been characterized as a glucose sensor and not a transporter. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271372 Cd Length: 496 Bit Score: 69.24 E-value: 2.10e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 29 LMFGAFVGITLWITGAAARRTRTVSDFYTGG-GITGFQNGLAMAGDYCSAASFLGITSQIFNDG-------YDGLIYAIG 100
Cdd:cd11478 4 LIVAVYFVFVLGIGFYLKRKVKTSEDFFLSGrSLPAWITGLAFISANLGALEIVGMSANGAQYGiatvhfyWIGAIPAMV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 101 FLvGWPIVLFLIAEKLRnlgrfTFADVASYRFlQGPVRSFSAISTLLVVSFYLIAQMVGAGQLVQLLFGLPYLYAIVVVG 180
Cdd:cd11478 84 FL-GIVMMPFYYGSKVR-----SVPEYLKLRF-NKSTRLLNAVSFAVMTILMSGINLYALALVLNVLLGWPLWLSIILSA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 181 GLMMVYVLFGGMRATSWVQIIKAVMLLCGATFLVLGVMAHVGfSFEALFARavavktklaLDSGLAPGDAAAKGRAIMGP 260
Cdd:cd11478 157 AIVLAYTTLGGLTSAIYNEVLQFFLIVAGLIPLVIIGLIKVG-GWDGLSEK---------IDANGPPGWNGLSWGPQGSQ 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 261 GGFIKDPISALSFG--FALMLGTAGLPH-ILMRFFTVPDAREARKSIMWATVWIGYFYALTFVLGFGAIVMISfnpdyvD 337
Cdd:cd11478 227 STNPMGVNLGLVFGlgFVLSFGYWTTNFlEVQRAMAAKDLSAARRTPLIAAFPKMFIPFLVILPGLIALVLVP------E 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 338 AAGALRGGNNMAVMHLAHAIGGNLFLGFISAVAFATILAVVAGLTLSAASAISHDVYASVIRKgDADPGKELRVSRITTI 417
Cdd:cd11478 301 LGASGGLDYNQALPYLMAKYLPPGLLGLGITALLAAFMSGMAGNVSAFNTVFTYDIYQTYIVK-DAPDKHYLKVGRIATV 379
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 695172230 418 LLGIAAIILG-IVFEKQNVAFMVSLAFALAASGNFPVLVMSLLWKGCTTKGAAWGGAIGLLAAFGLTLVSPVIWV 491
Cdd:cd11478 380 VGVLISIGTAyIASSFNNIMDYLQLLFSFFNAPLFATFLLGMFWKRATPWGGFWGLLAGTASAIVLYGLYELGLI 454
|
|
| SLC5sbd_NIS-like |
cd10326 |
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute ... |
28-500 |
1.72e-11 |
|
Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; NIS (product of the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. SMVT (product of the SLC5A6 gene) transports biotin, pantothenic acid and lipoate. This subfamily also includes SMCT1 and 2. SMCT1(the product of the SLC5A8 gene) is a high-affinity transporter of various monocarboxylates including lactate and pyruvate, short-chain fatty acids, ketone bodies, nicotinate and its structural analogs, pyroglutamate, benzoate and its derivatives, and iodide. SMCT2 (product of the SLC5A12 gene) is a low-affinity transporter for short-chain fatty acids, lactate, pyruvate, and nicotinate. This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271361 [Multi-domain] Cd Length: 472 Bit Score: 66.43 E-value: 1.72e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 28 ILMFGAFVGITLWITGAAARRTRTVSDFYTGGG-ITGFQNGLAMAGDYCSAASFLGITSQIFNDGYDGLIYAIGFLVGWP 106
Cdd:cd10326 2 WAVVVVYFLILLAISYYTSRRNADNDDFFLGNRqSPWYLVAFSMIGTSLSGVTFVSVPGEVGGSGFTYLQMVLGFLLGYL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 107 IVLFLIaeklrnLGRFTFADVAS-YRFLQgpvRSFSAISTLLVVSFYLIAQMVGAG-----------QLVQLLFGLPYLY 174
Cdd:cd10326 82 IIAFVL------LPLYYRLNLTSiYEYLE---DRFGVSSRKTGAVFFLLSRILGAGirlylvalvlqQFLFDSLGIPFWL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 175 AIVVVGGLMMVYVLFGGMRATSWVQIIKAVMLLCGATFLVLGVMAHVGFSFEALFaravavktklaldsglapGDAAAKG 254
Cdd:cd10326 153 TVLITGLLIWLYTFRGGIKTVVWTDTLQTVFLLVGLVLTIIIISNSLGLGFGEAI------------------SAAGESG 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 255 RAIMgpgGFIKDPISALSF------GFALMLGTAGLPHILM-RFFTVPDAREARKSIMWAtvWIGYFYALTFVLGFGAIV 327
Cdd:cd10326 215 YSRI---FNFDDDNSRRTFwkqflgGIFITIAMTGLDQDMMqRNLSCKNLKDAQKNMLTF--GVILVPVNLLFLLLGVLL 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 328 MIsfnpdYVDAAGALRGGNN-------MAVMHLAHAIGGNLFLGFISAvAFATilaVVAGLTlSAASAISHDVYaSVIRK 400
Cdd:cd10326 290 YT-----YAQKNGIALPAKDsdqlfpyFALNGLPPGVSGLFVAGIIAA-AMSS---ADSALT-ALTTSFCVDIL-NRFKR 358
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 401 GDADPGKELRVSRITTILLGIAAIILGIVFEKQNVafmVSLAFALAASGNFPVLVMSLLwkGCTTKGA---AWGGAIGLL 477
Cdd:cd10326 359 KSEKKSERKYVHIAFSLTFVLGILVFGSASNSGSL---IDAIFKVAGYTYGPLLGLFAF--GLFTKRAvkdKWVPLVGLL 433
|
490 500
....*....|....*....|....*.
gi 695172230 478 AA---FGLTLVSPVIWVAVFGFERAI 500
Cdd:cd10326 434 APvlsYLLVSNSEGFFGYKFGFELLI 459
|
|
| SLC5sbd_SGLT1-like |
cd10329 |
Na(+)/glucose cotransporter SGLT1 and related proteins; solute binding domain; This subfamily ... |
34-556 |
6.72e-10 |
|
Na(+)/glucose cotransporter SGLT1 and related proteins; solute binding domain; This subfamily includes the solute-binding domain of SGLT proteins that cotransport Na+ with various solutes. Its members include: the human glucose (SGLT1, -2, -4, -5 ), chiro-inositol (SGLT5), and myo-inositol (SMIT) cotransporters. It also includes human SGLT3 which has been characterized as a glucose sensor and not a transporter. It belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271363 Cd Length: 538 Bit Score: 61.44 E-value: 6.72e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 34 FVGITLWITGAAARRTRTVSDFYTGG-GITGFQNGLAMAGDYCSAASFLGITSQIFNDG-----YDGLIYAIGFLVGWPI 107
Cdd:cd10329 8 FVAVIAIGLWSSRKKRSTVSGYFLAGrSMGWPVIGASLFASNIGSSHLVGLAGSGAASGiavgnYEWNAAFVLLLLGWVF 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 108 VLFLIAeklrnLGRFTFADVASYRFlQGPVRSFSAISTLLVVSFYLIAQMVGAGQLV-QLLFGLPYLYAIVVVGGLMMVY 186
Cdd:cd10329 88 LPFYIR-----SGVSTMPEFLEKRF-GGRSRVYLSVLSLILYVFTKISVDLYAGALViKQLLGWDLYLSIIVLLVITAIY 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 187 VLFGGMRATSWVQIIKAVMLLCGATFLVLGVMAHVGFSFEALFArAVAVKTKLALdsgLAPGDAAakgrAIMGPGGFIKD 266
Cdd:cd10329 162 TIAGGLKAVIYTDTLQAVILIIGSAILMFLAFNEVGGGWSAYMA-AIPSGTAFHL---FRPPDDP----DLPWPGLLLGY 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 267 PISALSFGFALMlgtaglpHILMRFFTVPDAREARksimWATVWIGYFYALTFVL----GFGAIVMISFNPDYVDAAGAL 342
Cdd:cd10329 234 PILGIWYWCTDQ-------VIVQRVLAAKNLKHAR----RGALFAGYLKLLPLFLmvlpGMIARALFPDLVACVVPCGNG 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 343 RGGNNMAVMHLAHAIGGNLFLGFISAVAFATILAVVAGLTLSAASAISHDVYASVIRKgdADPGKELRVSRITT-ILLGI 421
Cdd:cd10329 303 VGCSDIAYPTLVTELLPVGLRGLVLAVLLAALMSSLTSIFNSASTLFTMDIYKRLRPE--ASEKELVRVGRIATlVVVVI 380
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 422 AAIILGIVFEKQNVAFMV-SLAFALAASGNFPVLVMSLLWKGCTTKGAAWGGAIGLLAA---FGLTLVSPVIWVAVFGFE 497
Cdd:cd10329 381 SILWAPIIQAQGGSLFNYiQSVLSYLAPPIAAVFLLGIFWKRTNEQGAFWGLIAGLVLGlvrLILEFAYGEPDTRPAIIG 460
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*....
gi 695172230 498 RAIFPYSSPALFSVpaGFLAIWLISTLDRSPRAAIDRAGYPNQRLRSETGIGVHESVSH 556
Cdd:cd10329 461 GIHFLYFAFLLFVV--SVIVTVIVSLLTPPPPAEKLAGLTWSTRLTKETSTLERPPWYK 517
|
|
| SLC5sbd_vSGLT |
cd10325 |
Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute ... |
35-489 |
8.40e-06 |
|
Vibrio parahaemolyticus Na(+)/galactose cotransporter (vSGLT) and related proteins; solute binding domain; vSGLT transports D-galactose, D-glucose, and alpha-D-fucose, with a sugar specificity in the order of D-galactose >D-fucose >D-glucose. It transports one Na+ ion for each sugar molecule, and appears to function as a monomer. vSGLT has 13 transmembrane helices (TMs): TM-1, an inverted topology repeat: TMs1-5 and TMs6-10, and TMs 11-12 (TMs numbered to conform to the solute carrier 6 family Aquifex aeolicus LeuT). This subfamily belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271360 Cd Length: 523 Bit Score: 48.46 E-value: 8.40e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 35 VGITLWITGAAARRTRTVSD-FYTGGGITGFQNGLAMAGDYCSAASFLGITSQIFNDG-----YDgLIYAIGFLVgwpIV 108
Cdd:cd10325 11 IGLGLWVSREKKGGEKDATDyFLAGKSLPWWAIGASLIAANISAEQFIGMSGSGFAIGlaiasYE-WMAAITLII---VA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 109 LFLIAEKLRNlGRFTFADVASYRFlQGPVRSFSAISTLLVVSFYLIAQMVGAGQL-VQLLFGLPYLYAIVVVGGLMMVYV 187
Cdd:cd10325 87 KFFLPIFLKN-GIYTMPQFLEERY-DGRVRTIMAVFWLLLYVFVNLTSVLYLGALaIETITGIPLTYSIIGLALFAAAYS 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 188 LFGGMRATSWVQIIKAVMLLCGAtflvlGVMAHVGFSFEALFARAVAVKTKLAldsglapgdAAAKGRAIM---GPGGFI 264
Cdd:cd10325 165 IYGGLKAVAWTDVIQVVFLVLGG-----LVTTYIALSLLGGGEGVFAGFTLLA---------AEAPEHFHMildKSNPED 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 265 KDP----ISALSFGFALM-LGTAGL-PHILMRFFTVPDAREARKSIMWATvWIGYFYALTFVL-GFGAIVMISfNPDYVD 337
Cdd:cd10325 231 AYKdlpgIAVLLGGLWVAnLSYWGFnQYIIQRALAAKSLSEAQKGIVFAA-FLKLLIPFIVVIpGIAAYVLAS-NLLLPA 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 338 AAGALRGGNNMAVMhLAHAIGGnlFLGFISAVAFATILAVVAGLTLSAASAISHDVYASVIRKgDADPGKELRVSRITti 417
Cdd:cd10325 309 ATGIEKPDQAYPWL-LRNLPTG--LKGLVFAALTAAIVSSLASMLNSISTIFTMDIYKKYIPK-KASEKQLVNVGRLA-- 382
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 695172230 418 llGIAAIILGIVFEKQNVAFMVSLAF-----ALAASGNFPVLVMSLLWKGCTTKGAAWGGAIGLLAAFGLTLVSPVI 489
Cdd:cd10325 383 --AVIALIIAALIAPPLLGLDQAFQYiqeytGFISPGILAIFLLGLFWKRATSAGALVAAILSIVLSALFKFLLPEL 457
|
|
| SLC5sbd_NIS-like_u1 |
cd11493 |
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative ... |
28-503 |
1.17e-05 |
|
uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Proteins belonging to the same subfamily as this uncharacterized subgroup include i) NIS, which transports I-, and other anions including ClO4-, SCN-, and Br-, ii) SMVT, which transports biotin, pantothenic acid and lipoate, and iii) the Na(+)/monocarboxylate cotransporters SMCT1 and 2. SMCT1 is a high-affinity transporter while SMCT2 is a low-affinity transporter. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271384 [Multi-domain] Cd Length: 479 Bit Score: 47.98 E-value: 1.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 28 ILMFGAFVGITLWITGAAARRTRTVSDFYTGGG-ITGFQNGLAMAGDYCSAASFLGITSQIFNDGYDGLIYAIGFLVGWP 106
Cdd:cd11493 2 LAVIVLYLLGLPLLGLWLSGRQKSTADYFLGGRsMPWWAVCLSVVATETSTLTFLSIPGLAYGGDLTFLQLALGYILGRI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 107 IVLFLIAEKLRNLGRFTFADVASYRFLQGPVRSFSA---ISTLLV--VSFYLIAQMVGAGqLVQLLFGLPYLYAIVVVGG 181
Cdd:cd11493 82 IVAFVLLPRYFRGEVVSAYELLGQRFGGGMQKTASVtflVTRLLAdgVRLFAAAIPVSMI-LGADGVALSYIASILIISV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 182 LMMVYVLFGGMRATSWVQIIKAVMLLCGATFLVLGVMAHVGFSFEALFARAVAVKTKLALDSGLAPGDAAAkgraimgpg 261
Cdd:cd11493 161 VTLLYTYFGGIRAVVWTDVIQLVVYIGGAVAALAYLLGALPADWLQIAAAAGKFHLFDLSDLILGLTSPYT--------- 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 262 gfikdPISALSFGFALMLGTAGLPHILM-RFFTVPDAREARKSIMWATVWIGYFYALTFVLGFGAIVmisFNPDYVDAAG 340
Cdd:cd11493 232 -----FWAAIIGGALLSMASHGTDQLMVqRLLACRNLRDAQKALIGSGVVVFPQFALFLLIGLLLYV---YYGGASLAAL 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 341 ALRGGNNMAVMHLAHAIGGNLfLGFISAVAFATILAVVAGLTLSAASAISHDVYASVIRKGDADPGKeLRVSRITTILLG 420
Cdd:cd11493 304 GLGSPDEVFPYFIVHELPAGL-RGLLIAGILAAAMSTLSSALNSLASSTVQDLYQPWKRRRLSDEKL-LRASRLLTLVWA 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 421 IAAIILGIVFEKQNVAfMVSLA---FALAASGNFPVLVMSLLWKGCTTKGAAWGGAIGLLAafgLTLVSPVIWVAVFGFE 497
Cdd:cd11493 382 VVLVGIALLFQYTDQP-VVELGlsiASFTYGGLLGVFLLGLLTRRASQRDAIAAFIVGFLV---MLLLIFGVKFLGLLFA 457
|
....*.
gi 695172230 498 RAiFPY 503
Cdd:cd11493 458 LA-FPW 462
|
|
| SLC5sbd_NIS |
cd11503 |
Na(+)/iodide cotransporter NIS and related proteins; solute-binding domain; NIS (product of ... |
29-209 |
1.46e-05 |
|
Na(+)/iodide cotransporter NIS and related proteins; solute-binding domain; NIS (product of the SLC5A5 gene) transports I-, and other anions including ClO4-, SCN-, and Br-. NIS is expressed in the thyroid, colon, ovary, and in human breast cancers. It mediates the active transport and the concentration of iodide from the blood into thyroid follicular cells, a fundamental step in thyroid hormone biosynthesis, and is the basis of radioiodine therapy for thyroid cancer. Mutation in the SLC5A5 gene can result in a form of thyroid hormone dysgenesis. Human NIS exists mainly as a dimer stabilized by a disulfide bridge. This subgroup belongs to the solute carrier 5 (SLC5) transporter family.
Pssm-ID: 271393 Cd Length: 535 Bit Score: 47.92 E-value: 1.46e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 29 LMFGAFVGITLWITGAAARRtRTVSDFYTGG-GITGFQNGLAMAGDYCSAASFLGITSQIFNDGYDGLIYAIGFLVGWPI 107
Cdd:cd11503 8 AMLLVSTGIGLFVGLARGGQ-RSADDFFTGGrGLSAVPVGLSLSASFMSAVQVLGVPSEAYRYGLKFLWMCLGQLLNSLM 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 108 VLFLIAEKLRNLGRFTFADVASYRFLQGpVRSFSAISTLLVVSFYLIAQMVGAGQLVQLLFGLPYLYAIVVVGGLMMVYV 187
Cdd:cd11503 87 TAVLFMPVFYRLGITSTYQYLEMRFSRA-VRLCGTLQFIVATMLYTGIVIYAPALILNQVTGLDIWASLFSTGIICTFYT 165
|
170 180
....*....|....*....|..
gi 695172230 188 LFGGMRATSWVQIIKAVMLLCG 209
Cdd:cd11503 166 TVGGMKAVIWTDVFQVVVMLSG 187
|
|
| MntH |
COG1914 |
Mn2+ or Fe2+ transporter, NRAMP family [Inorganic ion transport and metabolism]; |
136-221 |
8.27e-04 |
|
Mn2+ or Fe2+ transporter, NRAMP family [Inorganic ion transport and metabolism];
Pssm-ID: 441518 [Multi-domain] Cd Length: 405 Bit Score: 42.05 E-value: 8.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 136 PVRSFSAISTLLVVSFYLIAQMVGAGQLVQLLFGLPYLYAIVVVGGLMMVYVLFGGMRAtsWVQIIKAVMLLCGATFLVL 215
Cdd:COG1914 84 WLGWLLLILLELANLATDAAEIAGAALALNLLFGIPLLLGAVITALLAILLLLRGGYRR--LERVLKVLVALMLLAFVVT 161
|
....*.
gi 695172230 216 GVMAHV 221
Cdd:COG1914 162 AFLAHP 167
|
|
| SLC5sbd_SGLT1 |
cd11486 |
Na(+)/glucose cotransporter SGLT1;solute binding domain; Human SGLT1 (hSGLT1) is a ... |
92-481 |
3.01e-03 |
|
Na(+)/glucose cotransporter SGLT1;solute binding domain; Human SGLT1 (hSGLT1) is a high-affinity/low-capacity glucose transporter, which can also transport galactose. In the transport mechanism, two Na+ ions first bind to the extracellular side of the transporter and induce a conformational change in the glucose binding site. This results in an increased affinity for glucose. A second conformational change in the transporter follows, bringing the Na+ and glucose binding sites to the inner surface of the membrane. Glucose is then released, followed by the Na+ ions. In the process, hSGLT1 is also able to transport water and urea and may be a major pathway for transport of these across the intestinal brush-border membrane. hSGLT1 is encoded by the SLC5A1 gene and expressed mostly in the intestine, but also in the trachea, kidney, heart, brain, testis, and prostate. The WHO/UNICEF oral rehydration solution (ORS) for the treatment of secretory diarrhea contains salt and glucose. The glucose, along with sodium ions, is transported by hSGLT1 and water is either co-transported along with these or follows by osmosis. Mutations in SGLT1 are associated with intestinal glucose galactose malabsorption (GGM). Up-regulation of intestinal SGLT1 may protect against enteric infections. SGLT1 is expressed in colorectal, head and neck, and prostate tumors. Epidermal growth factor receptor (EGFR) functions in cell survival by stabilizing SGLT1, and thereby maintaining intracellular glucose levels. SGLT1 is predicted to have 14 membrane-spanning regions. This subgroup belongs to the solute carrier 5 (SLC5)transporter family.
Pssm-ID: 271379 Cd Length: 636 Bit Score: 40.30 E-value: 3.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 92 YDGLIYAIgfLVGWPIVLFLIAEklrnlGRFTFADVASYRFLQGPVRSFSAISTLLVVSFYLI-AQMVGAGQLVQLLFGL 170
Cdd:cd11486 77 WNALVVVV--VLGWLFVPIYIKA-----GVVTMPEYLRKRFGGQRIQVYLSVLSLCLYIFTKIsADIFSGAIFINLALGL 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 171 PYLYAIVVVGGLMMVYVLFGGMRATSWVQIIKAVMLLCGaTFLVLGVMAHVGFSFEALFARAVAvktklALDSGLAPGDA 250
Cdd:cd11486 150 NLYLAIVILLAITALYTITGGLAAVIYTDTLQTIIMVVG-SFILMGFAFNEVGGYDAFMEKYMT-----AIPSVIGTGNS 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 251 AAKGRAIMGPGG---FIKDPISA------LSFGFALMLGTAGLPH--ILMRFFTVPDAREARKsimwATVWIGYFYAL-T 318
Cdd:cd11486 224 TSQEKCYTPRADsfhIFRDPITGdlpwpgLLFGLSILTLWYWCTDqvIVQRCLSAKNMSHVKA----GCILCGYLKLLpM 299
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 319 FVLGFGAIVMISFNPDYV---------DAAGALRGGNNMAVMHLAHAIGGNLFLGFISAVAFATILAVVAGLTLSAASAI 389
Cdd:cd11486 300 FIMVMPGMISRILYTDEIacvvpdeckAVCGTEVGCTNIAYPKLVVELMPNGLRGLMLSVMLASLMSSLTSIFNSASTLF 379
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 390 SHDVYASVIRKGDAdpgKELRVS--RITTILLGIAAIILGIVFEKQN-------VAFMVSLAFALAAsgnfpVLVMSLLW 460
Cdd:cd11486 380 TMDIYTKVRKKASE---KELMIAgrLFMLVLIGISIAWVPIVQSAQSgqlfdyiQSITSYLGPPIAA-----VFLLAIFC 451
|
410 420
....*....|....*....|.
gi 695172230 461 KGCTTKGAAWGGAIGLLAAFG 481
Cdd:cd11486 452 KRVNEPGAFWGLCVGLLVGLA 472
|
|
| PRK10484 |
PRK10484 |
putative transporter; Provisional |
25-426 |
5.29e-03 |
|
putative transporter; Provisional
Pssm-ID: 236699 [Multi-domain] Cd Length: 523 Bit Score: 39.48 E-value: 5.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 25 WTAILMFGAFVGITLWITGAAARRTRTVSD---FYTGGGITGFQNGLAMAGDYCSAASFLGITSQIFNDGYDGLIYAIGF 101
Cdd:PRK10484 1 MLTILSFLGFTLLVAVISWWKTRKTDTSSSdgyFLAGRSLTGPVIAGSLLLTNLSTEQLVGLNGQAYASGMSVMAWEVTA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 102 LVGWPIVLFLIAEKLRNLGRFTFADVASYRFLQGpVRSFSAISTLL--VVSFYLIAQMVGAGQLVQL-----LFGLPYLY 174
Cdd:PRK10484 81 AIALIILALIFLPRYLKSGITTIPDFLEERYDKT-TRRIVSILFLIgyVVSFLPIVLYSGALALNSLfhvseLLGISYGA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 175 AI----VVVGGLMMVYVLFGGMRATSWVQIIKAVMLLCGATFL-VLGVMAHVGFSFEALFARAVAvktklaldsglapgD 249
Cdd:PRK10484 160 AIwllvWLIGIIGAIYAVFGGLKAVAVSDTINGIGLLIGGLLVpVFGLIALGDGSFMQGLEQLTT--------------V 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 250 AAAKGRAIMGPGGFIkdPISALSFG--FALMLGTAGLPHILMRFFTVPDAREARKSIMWAtvwiGYFYALT-FVLGFGAI 326
Cdd:PRK10484 226 HPEKLNSIGGATDPV--PFPTLFTGliLVNLFYWCTNQSIVQRALGAKNLAEGQKGALLA----AFFKLLGpLILVLPGI 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695172230 327 VMISFNPDYVDAAgalrggnNMAVMHLAHAIGGNLFLGFISAVAFATILAVVAGLTLSAASAISHDVYASVIRKgDADPG 406
Cdd:PRK10484 300 IAFHLYGDGLPNA-------DMAYPTLVNDVLPVPLVGFFAAVLFGAILSTFNGFLNSASTLFSLDIYKPIINP-NASEK 371
|
410 420
....*....|....*....|
gi 695172230 407 KELRVSRITTILLGIAAIIL 426
Cdd:PRK10484 372 QLVKVGKKFGFVLAIISMIV 391
|
|
| |
