|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
17-417 |
2.62e-80 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 251.72 E-value: 2.62e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 17 RWTIIALFVVAMIINYLTRSILGVAAPAIMAEQHISSAQYSWITGAFQFGIM-FQPLAGYLLDVIGLKVGFTLFVAIWSC 95
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYAlFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 96 ITLGHGFANGWMGFAGLRGALGLVEGSAQPAGMKLVAEWFPARERGVAGGIYQIGASFGAVFAPPLVAWAVFNHSWRAAF 175
Cdd:cd17319 81 FTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 176 FVAGGLGLAWVVAWLAWYappqrhrrlsdgertlivagqeaalvkhrrrpplgellrkRNLWTIAAARFLADPVWGMLSL 255
Cdd:cd17319 161 IIEGLLGLLLAVLWWFYL----------------------------------------RQVWGLALGYFGINYALYGLLT 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 256 WMPLYLVQARHFDLGQIALFAWLPFLAADLGCLFGPAVVAFLQRRGvglidARRGAFTLGAVLMTGMMFVGTVTSPAAAI 335
Cdd:cd17319 201 WLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGA-----RRLVIIIGLLLAAVGLLLAYLTTSPVVAV 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 336 ALLCLGGFAHQTLSVTVITLCSDLFPHDQVATATGVSGTAANLGVLIFTLSLGSMVDQIG-YQPFFIVLGLLDLVGAALL 414
Cdd:cd17319 276 ILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGsYTAAFLFLAAVALLAALLV 355
|
...
gi 695171606 415 WTL 417
Cdd:cd17319 356 LLL 358
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
26-418 |
4.49e-79 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 249.95 E-value: 4.49e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 26 VAMIINYLTRSILGVAAPAIMAEQHISSAQYSWITGAFQFG-IMFQPLAGYLLDVIGLKVGFTLFVAIWSCITLGHGFAN 104
Cdd:TIGR00893 1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGyVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 105 GWMGFAGLRGALGLVEGSAQPAGMKLVAEWFPARERGVAGGIYQIGASFGAVFAPPLVAWAVFNHSWRAAFFVAGGLGLA 184
Cdd:TIGR00893 81 AYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFIIEGVLGII 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 185 WVVAWLAWYAPPQRHRRLSDGERTLIVAGQEAA-----LVKHRRRPPLGELLRKRNLWTIAAARFLADPVWGMLSLWMPL 259
Cdd:TIGR00893 161 WGVLWLKFIPDPPQKAKWLTEEEKYIVVGGLLAeqqgkGPSTPKKYQIKELLKDRRVWGLALGQFLVNIGLGFFLTWFPT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 260 YLVQARHFDLGQIALFAWLPFLAADLGCLFGPAVVAFLQRRGVGLIDARRGAFTLGAVLMTGMMFVGTVTSPAAAIALLC 339
Cdd:TIGR00893 241 YLVQERGLSILEAGFMASLPGIVGFIGMILGGRLSDLLLRRGKSLVFARKTAIIAGLVLSLLMFATNYVNIPYAALALVA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 340 LGGFAHQtLSVTVITLCSDLFPHDQVATATGVSGTAANLGVLIFTLSLGSMVDQIG-YQPFFIVLGLLDLVGAALLWTLI 418
Cdd:TIGR00893 321 LGFFGLG-AGAIGWALISDNAPGNIAGLTGGLINSLGNLGGIVGPIVIGAIAATTGsFAGALMVVAALALIGALSYLLLV 399
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
11-421 |
4.84e-59 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 196.63 E-value: 4.84e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 11 RRFPYIRWTIIALFVVAMIINYLTRSILGVAAPAIMAEQHISSAQYSWITGAFQFGIM-FQPLAGYLLDVIGLKVGFTLF 89
Cdd:COG2271 2 RAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYAlGQIPAGLLADRFGRRRVLAIG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 90 VAIWSCITLGHGFANGWMGFAGLRGALGLVEGSAQPAGMKLVAEWFPARERGVAGGIYQIGASFGAVFAPPLVAWAVFNH 169
Cdd:COG2271 82 LLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 170 SWRAAFFVAGGLGLAWVVAwlawyappqrhrrlsdgertlivagqeaalvkhrrrpplgellrkrNLWTIAAARFLADPV 249
Cdd:COG2271 162 GWRAAFLILGLPGLLLALL----------------------------------------------RFWLLALAYFLVYFA 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 250 WGMLSLWMPLYLVQARHFDLGQIALFAWLPFLAADLGCLFGPAVVAFLQRRgvglidaRRGAFTLGAVLMT-GMMFVGTV 328
Cdd:COG2271 196 LYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRR-------RKLVLAIGLLLAAlALLLLALL 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 329 TSPAAAIALLCLGGFAHQTLSVTVITLCSDLFPHDQVATATGVSGTAANLGVLIFTLSLGSMVDQIGYQPFFIVLGLLDL 408
Cdd:COG2271 269 PSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALAL 348
|
410
....*....|...
gi 695171606 409 VGAALLWTLIRKA 421
Cdd:COG2271 349 LAALLALLLLRET 361
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
16-421 |
5.49e-42 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 152.34 E-value: 5.49e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 16 IRWTIIALFVVAMIINYLTRSILGVAAPAIMAEQHISSAQYSWITGAFQ-FGIMFQPLAGYLLDVIGLKVGFTLFVAIWS 94
Cdd:COG2223 2 GRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVlVGALLRIPLGFLVDRFGPRRVLLIGLLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 95 CITLGHGFANGWMGFAGLRGALGLVEGSAQPAGMKLVAEWFPARERGVAGGIYQIGASFGAVFAPPLVAWAVFNHSWRAA 174
Cdd:COG2223 82 IGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 175 FFVAGGLGLAWVVAWLAWYAPPQRHRRLSdgertlivagqeaalvKHRRRPPLGELLRKRNLWTIAAARFLADPVWGMLS 254
Cdd:COG2223 162 FLILGILLLVVAVLAWLFLRDPPAGAAAA----------------AKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFS 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 255 LWMPLYLVQARHFDLGQIALFAWLPFLAADLGCLFGPAVVAFLQRRGVGLIdarrgAFTLGAVLMTGMMFvgTVTSPAAA 334
Cdd:COG2223 226 SWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLI-----VFALMALGLLLLAL--ALGSLWLF 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 335 IALLCLGGFAHQTLSVTVITLCSDLFPHDQVATATGVSGTAANLGVLIFTLSLGSMVDQIG-YQPFFIVLGLLDLVGAAL 413
Cdd:COG2223 299 LVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVL 378
|
....*...
gi 695171606 414 LWTLIRKA 421
Cdd:COG2223 379 TLLLYRRP 386
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
14-379 |
4.11e-31 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 122.00 E-value: 4.11e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 14 PYIRWTIIALFVVAMIINYLTRSILGVAAPAIMAEQHISSAQYSWITGAFQFGIM-FQPLAGYLLDVIGLKVGFTLFVAI 92
Cdd:COG2814 5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAAlGAPLAGRLADRFGRRRVLLLGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 93 WSCITLGHGFANGWMGFAGLRGALGLVEGSAQPAGMKLVAEWFPARERGVAGGIYQIGASFGAVFAPPLVAWAVFNHSWR 172
Cdd:COG2814 85 FALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 173 AAFFVAGGLGLAwVVAWLAWYAPPQRHRRlsdgertlivagqeaalvKHRRRPPLGELLRKRNLWTIAAARFLADPVWGM 252
Cdd:COG2814 165 WVFLVNAVLALL-ALLLLLRLLPESRPAA------------------RARLRGSLRELLRRPRLLLLLLLAFLLGFGFFA 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 253 LSLWMPLYLVQARHFDLGQIALFawlpFLAADLGCLFGPAVVAFLQRRgvglIDARRGAFTLGAVLMTGMMFVGTVTSPA 332
Cdd:COG2814 226 LFTYLPLYLQEVLGLSASAAGLL----LALFGLGGVLGALLAGRLADR----FGRRRLLLIGLLLLALGLLLLALAGSLW 297
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 695171606 333 AAIALLCLGGFAHQTLSVTVITLCSDLFPHDQVATATGVSGTAANLG 379
Cdd:COG2814 298 LLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
24-384 |
1.22e-29 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 117.90 E-value: 1.22e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 24 FVVAMIINYLTRSILGVAAPAIMAEQ-HISSAQYSWITGAFQFG-IMFQPLAGYLLDVIGLKVGFTLFVAIWSCITLGHG 101
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDlGISPTEIGLLLTLFSLGyALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 102 FANGWMGFAGLRGALGLVEGSAQPAGMKLVAEWFPARERGVAGGIYQIGASFGAVFAPPLVAWAVFNHSWRAAFFVAGGL 181
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 182 GLAWVVAWLAWYAPPQRHRRLsdgertlivagqEAALVKHRRRPPLGELLRKRNLWTIAAArFLADPVWGMLSLWMPLYl 261
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPK------------PAEEARLSLIVAWKALLRDPVLWLLLAL-LLFGFAFFGLLTYLPLY- 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 262 VQARHFDLGQIALFAWLPFLAADLGCLFGPAVVAFLQRRGVGLIdarrgAFTLGAVLMTGMMFVGTVTSPAAAIALLCLG 341
Cdd:pfam07690 227 QEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLL-----ALLLLILAALGLLLLSLTLSSLWLLLALLLL 301
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 695171606 342 GFAHQTLSVTVITLCSDLFPHDQVATATGVSGTAANLGVLIFT 384
Cdd:pfam07690 302 GFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
32-400 |
3.86e-28 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 114.40 E-value: 3.86e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 32 YLTRSILGVAAPAIMAEQHISSAQYSWITGAFQFGIMF-QPLAGYLLDVIGLKVGFTLFVAIWSCITLGHGFANGWMGFA 110
Cdd:TIGR00881 8 YLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGIsKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 111 GLRGALGLVEGSAQPAGMKLVAEWFPARERGVAGGIYQIGASFGAVFAPPLV-AWAVFNHSWRAAFFVAGGLGLAWVVAW 189
Cdd:TIGR00881 88 ALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVlFGIAELYSWHWVFIVPGIIAIIVSLIC 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 190 LAWYAPPQRHRRLSDGERTLIVAGQEAALVKHRRRPP----LGELLRKRNLWTIAAAR-FLADPVWGMLSlWMPLYLVQA 264
Cdd:TIGR00881 168 FLLLRDSPQSCGLPPAEEMPNEEPDGDAEKKEEELTKkqifLQYVLLNKVLWYISLGYvFVYVVRTGILD-WSPLYLTQE 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 265 RHFDLGQIALFAWLPFLAADLGCLfgpaVVAFLQRRgvgLIDARRGAftLGAVLMTGMMF-------VGTVTSPAAAIAL 337
Cdd:TIGR00881 247 KGFSKEKASWAFTLYELGGLVGTL----LAGWLSDK---LFNGRRGP--LAVFFMALIIVsllvywlNPAANPLMDLICL 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 695171606 338 LCLGGFAHQTLSVTVItLCSDLFPHDQVATATGVSGTAANLGVLIFTLSLGSMVDQIGYQPFF 400
Cdd:TIGR00881 318 FALGFLVYGPQMLIGV-IASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFGWAGAF 379
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
24-418 |
1.08e-25 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 107.28 E-value: 1.08e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 24 FVVAMIINYLTRSILGVAAPAIMAEQHISSAQYSWITGAFQFG-IMFQPLAGYLLDVIGLKVGFTLFVAIWSCITLGHGF 102
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAqLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 103 ANGWMGFAGLRGALGLVEGSAQPAGMKLVAEWFPARERGVAGGIYQIGASFGAVFAPPLVAWAVFNHSWRAAFFVAGGLG 182
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 183 LawVVAWLAWYAPPQRHRRLSDGERTLIvagqeaalvkhRRRPPLGELLRKRNLWTIAAARFLADPVWGMLSLWMPLYLV 262
Cdd:cd17325 161 L--LALVLALLLLPEPRPPPNKRAVSAA-----------RLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAA 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 263 QARHFDLGQIALFawlpFLAADLGC-LFGPAVVAFLQRRGvglidaRRGAFTLGAVLMT-GMMFVGTVTSPAAAIALLCL 340
Cdd:cd17325 228 ELGGLSPAQIGLL----FGAQGLASaLSQPPAGKLSDRIG------RKPLILIGLLLSAvALLLLPLATSFWLLLLLLAL 297
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 695171606 341 GGFAHQTLSVTVITLCSDLFPHDQVATATGVSGTAANLGVLIFTLSLGSMVDQIGYQPFFIVLGLLDLVGAALLWTLI 418
Cdd:cd17325 298 LGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
24-415 |
9.31e-24 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 101.73 E-value: 9.31e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 24 FVVAMIINYLTRSILGVAAPAIMAEQHISSAQYSWITGAFQFG-IMFQPLAGYLLDVIGLKVGFTLFVAIWSCITLGHGF 102
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGyALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 103 ANGWMGFAGLRGALGLVEGSAQPAGMKLVAEWFPARERGVAGGIYQIGASFGAVFAPPLVAWAV--FNHSWRAAFFVAGG 180
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAssLGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 181 LGLAWVVAWLAWYAPPQRHRRLSDGERTlivagqeaalvKHRRRPPLGELLRKRNLWTIAAARFLADPVWGMLSLWMPLY 260
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEAS-----------SKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLF 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 261 LVQARHFDLGQIALFAWLPFLAADLGCLFGPAVVAFLQRRgvglidaRRGAFTLGAVLMTGMMFVGTVTSPAAAIALLCL 340
Cdd:cd06174 230 LLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGR-------KPLLLIGLLLMALGLALLLLAPSLLLLLLLLLL 302
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 695171606 341 GGFAHQTLSVTVITLCSDLFPHDQVATATGVSGTAANLGVLIFTLSLGSMVDQ-IGYQPFFIVLGLLDLVGAALLW 415
Cdd:cd06174 303 LGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAAtFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
38-415 |
7.21e-22 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 96.15 E-value: 7.21e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 38 LGVAAPAIMAEQHISSAQYSWITGAFQFGIMF-QPLAGYLLDVIGLKVGFTLFVAIWSCITLGHGFANGWMGFAGLRGAL 116
Cdd:cd17475 15 IPALAPFLQEDLHLSLAQVGLLLSALNLGVAVsMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 117 GLVEGSAQPAGMKLVAEWFPARERGVAGGIYQIGASFGAVFAPPLVAWAVFNHSWRAAFFVAGGLGLAWVVAWLAWYAPP 196
Cdd:cd17475 95 GAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 197 QrhrrlsdgertlivAGQEAALVKHRRRPPLGELLRKRNLWTIAAARF-LADPVWGMLSLWMpLYLVQARHFDLGQIALF 275
Cdd:cd17475 175 P--------------AASAATESASTLLRSLKEVLRNRDVWLIAIAGAlLVAPQFALLTFLL-LFLHDHLGLSVVAAGAL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 276 AWLPFLAADLGCLFGPAV---VAFLQRRGVGLIDArrgaftLGAVLMTGMMFVGTVTSPAAAIALLC----LGGFAHQTL 348
Cdd:cd17475 240 LAVAQLGGALGRIGLGRVsdrVFGGRRRPVLVITA------AIAAAALLVLSLLSPGTPLWLLVLLLillgLFAIGWNGL 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 695171606 349 SVTVItlcSDLFPHDQVATATGVSGTAANLGVLIFTLSLGSMVDQI-GYQPFFIVLGLLDLVGAALLW 415
Cdd:cd17475 314 YLTLV---AESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDAThSYAPAWLALALLLVLAALLLL 378
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
52-415 |
2.64e-21 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 94.99 E-value: 2.64e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 52 SSAQYSWITGAFQFG-IMFQPLAGYLLDVIGLKVGFTLFVAIWSCITLGHGFAN--GWMGFAGLRGALGLVEGSAQPAGM 128
Cdd:cd17318 54 SEKTQGIILSSFFYGyILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAArgGYGALIVLRILQGLAQGVTFPAMH 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 129 KLVAEWFPARERGVAGGIYQIGASFGAVFAPPLVAWAVFNHSWRAAFFVAGGLGLAWVVAWLaWYAPPqrhrrlsdgert 208
Cdd:cd17318 134 ALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWF-FLVLP------------ 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 209 livagqeaalvkhrrrpplgellrkrnLWTIAAARFLADPVWGMLSLWMPLYLVQARHFDLGQIALFAWLPFLAADLGCL 288
Cdd:cd17318 201 ---------------------------VWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSI 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 289 FGPAVVAFLQRRGVGLIDARRGAFTLGAVLMTGMMFVGTV---TSPAAAIALLCL----GGFAHQTLSVTVItlcsDLFP 361
Cdd:cd17318 254 VGGYLADWLRSRGILSTTTVRKLFTSIGFLGPGVFLIALGylgSNATLAVVFLTLsvglSGACYSGFLVNHL----DLAP 329
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 695171606 362 hDQVATATGVSGTAANLGVLIFTLSLGSMV----DQIGYQPFFIVLGLLDLVGAALLW 415
Cdd:cd17318 330 -NYAGTLMGITNTAATIAGIISPLIVGAIVkndqTIGQWRIVFFISAAIYILGAIFYL 386
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
21-412 |
3.92e-21 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 93.77 E-value: 3.92e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 21 IALFVVAMIINYLTRSILGVAAPAIMAEQHISSAQYSWITGAFQFG-IMFQPLAGYLLDVIGLKVGFTLFVAIWSCITLG 99
Cdd:cd17380 1 VILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGyALTQVLGGYLADRFGGKKVLLLAVALWSLATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 100 HGFANGW--MGFAGLRGALGLVEGSAQPAGMKLVAEWFPARERG-----VAGGIYqIGASFGAVFAPPLVAWavfnHSWR 172
Cdd:cd17380 81 TPLLAYSslPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSravsiVTAGSY-LGTLLGGLIGPLLLEY----YGWP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 173 AAFFVAGGLGLAWVVAWLaWYAPPqrhrrlsdgertlivagqeaalvkhrrrpplgellrkrnLWTIAAARFLADPVWGM 252
Cdd:cd17380 156 SVFYFFGLLGLLWALVWL-IYLPP---------------------------------------VWAIIVAHFCMNWGFYI 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 253 LSLWMPLYLvQARHFDLGQIALFAWLPFLAADLGCLFGPAVVAFLQRRGVGLIDARR---GAFTLGAVLmtGMMFVGTVT 329
Cdd:cd17380 196 LLSWLPTYF-HEVLVPLAKGWVFNVVPWLVMFPSSNVAGWLADHLISRGWTVTSVRKlmqSIGFLGPAL--FLLLLSHTD 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 330 SPAAAIALLCLG----GFAHQTLSVTVItlcsDLFPhdQVATAT-GVSGTAANLGVLIFTLSLGSMVDQIG-YQPFFIVL 403
Cdd:cd17380 273 SFSLALLCMSVAlglsAFSSSGVLVNHQ----DIAP--NYAGIVfGISNTAGTIPGIVGVYLTGYILEATGsWSLVFVLA 346
|
....*....
gi 695171606 404 GLLDLVGAA 412
Cdd:cd17380 347 AVVNLVGAV 355
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
17-418 |
6.93e-18 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 84.63 E-value: 6.93e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 17 RWTIIALFVVAMIINYLTRSILGVAAPAIMAEQHISSAQYSWITGAFQFGIMF-QPLAGYLLDVIGLKVGFTLFVAIWSC 95
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVgKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 96 ITLGHGFANGWMGFAGLRGALGLVEGSAQPAGMKLVAEWFPARERGVAGGIYQIGASFGAVFAPPLVAWAVFNHSWRAAF 175
Cdd:cd17312 81 ANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 176 FVAGGLGLawVVAWLAWyappqrhRRLSDgertlivagqeaalvkhrrRPPLgellrkrnLWTIAAARFLADPVWGMLSL 255
Cdd:cd17312 161 LVPGIVGL--VVAIILF-------FFLRD-------------------SPPY--------VWVLSLAYAFVYIVRYACLD 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 256 WMPLYLVQARHFDLGQIALFAwlpfLAADLGCLFGPAV------VAFLQRRGVGLIdarrgAFTLGAVLMTGMMFVGTVT 329
Cdd:cd17312 205 WGPLYLYEVKGYSLIDAGWFS----SLYEVGGIAGTILagllsdKLFGGRRAPIAV-----IYMLLMTLSLALFWFFPHN 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 330 SPAAAIALLCLGGFAHQTLSVTVITLCSDLFPHDQVATATGVSGTAANLGVLIFTLSLGSMVDQIGYQPFFIVLGLLDLV 409
Cdd:cd17312 276 KLLSIVLLFLIGFFVGGPINLIGGAAAQDIGRKEAAGTATGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFLISAALL 355
|
....*....
gi 695171606 410 GAALLWTLI 418
Cdd:cd17312 356 SVLLLLSLW 364
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
18-391 |
1.88e-17 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 83.56 E-value: 1.88e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 18 WTIIALFVVAMIINYLTRSILGVAAPAIMAEQHISSAQYSWITGAFQFGIMFQPL-AGYLLDVIGLKVGFTLFVAIWSCI 96
Cdd:TIGR00895 16 WRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALfFGPLADRIGRRRVLLWSILLFSVF 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 97 TLGHGFANGWMGFAGLRGALGLVEGSAQPAGMKLVAEWFPARERGVAGGIYQIGASFGAVFAPPLVAWAVFNHSWRAAFF 176
Cdd:TIGR00895 96 TLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFY 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 177 VAGGLGLawVVAWLAWYAPPQ-----------RHRRLSDGERTLIVAGQEAALVKHRRRPPLGELLRK--------RNLW 237
Cdd:TIGR00895 176 VGGIAPL--LLLLLLMRFLPEsidflvskrpeTVRRIVNAIAPQMQAEAQSALPEQKSTQGTKRSVFKalfqgktaRITV 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 238 TIAAARFLADPVWGMLSLWMPLYLVQArHFDLGQIALFAWLPFLAADLGCLFGPAVVAFLQRRGVGLIdarrgaFTLGAV 317
Cdd:TIGR00895 254 LLWLLYFMLLVGVYFLTNWLPKLMVEL-GFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTALL------LLLGAV 326
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 695171606 318 LMTgmMFVGTVTSPAAAIALLCLGGFAHQTLSVTVITLCSDLFPHDQVATATGVSGTAANLGVLIFTLSLGSMV 391
Cdd:TIGR00895 327 FAV--LVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAGYLL 398
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
11-420 |
2.17e-17 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 83.36 E-value: 2.17e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 11 RRFPYIRWTIIALFVVAMIINyltrSILGVAAPAIMAEQHISSAQYSWITGAFQFGIMF-QPLAGYLLDVIGLKVGFTLF 89
Cdd:COG0738 4 KNYRRALIAIYLLFFLWGFAT----ALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLaSLPAGRLIDRFGYKRGLLLG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 90 VAIWSCITLGHGFANGWMGFAGLRGALGLVEGSAQPAGMKLVAEWFPARERGVAGgIYQIGASFGAVFAPPLVAWAVFNH 169
Cdd:COG0738 80 LLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLN-LLHAFFSLGALLGPLLGGLLILLG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 170 ---SWRAAFFVAGGLGLAWVVAWLAWYAPPQRHRRLSDGERtlivagqeaalvkhrrRPPLGELLRKRNLWTIAAARFLA 246
Cdd:COG0738 159 lslSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGS----------------AASLKSLLKNPRLLLGGLAIFLY 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 247 DPVWGMLSLWMPLYLVQARHFDLGQIALFAWLPFLAADLGCLFGPAVVAFLQRRGVglidarrgaFTLGAVLMT-GMMFV 325
Cdd:COG0738 223 VGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRL---------LRLSALLAAvGLLLA 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 326 GTVTSPAAAIALLCLGGFAHQTLSVTVITLCSDLFPHDQVATATGVSgTAANLGVLIFTLSLGSMVDQIGYQPFFIVLGL 405
Cdd:COG0738 294 LLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVL-IMGIVGGAIGPPLIGFLADAFGLRAAFLVPLV 372
|
410
....*....|....*
gi 695171606 406 LDLVGAALLWTLIRK 420
Cdd:COG0738 373 CYLLILLLALALKRK 387
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
32-415 |
5.41e-17 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 82.29 E-value: 5.41e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 32 YLTRSILGVAAPAIMAEQHISSAQYSWITGAFqfGIMF---QPLAGYLLDVIGLKVGFTLFVAIWSCITLGHGFANGWMG 108
Cdd:cd17345 16 YLVRNNFSLAQPYLIEQYGLSKTEIGLIGSAL--SIAYglsKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVPSATS 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 109 FAGLRGAL----GLVEGSAQPAGMKLVAEWFPARERGVAGGIYQIGASFGAVFAPPLVAWAV---FNHSWRAAFFVAGgl 181
Cdd:cd17345 94 SVGLMFILlflnGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLaifGDGWWRGAFIFPA-- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 182 GLAWVVAWLAWYA----------PPQRHRRlSDGERTLIVAGQEAAL------VKHrrrpplgeLLRKRNLWTIAAAR-F 244
Cdd:cd17345 172 IIAIIVAVIVLFLgkdtpeseglPPIEEYK-GDYPEEADGEEEEQELsaweifVKY--------VLKNKLLWYIAIANvF 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 245 LADPVWGMLSlWMPLYLVQARHFDLGQ----IALFAWlpflaadlGCLFGPAVVAFLQRRgvgLIDARRGAFTLGAVLMT 320
Cdd:cd17345 243 VYLVRYGILD-WAPTYLSEVKGFSKAQamwaFSLFEW--------AAIPGTLLAGWLSDK---LFKGRRAPTGIIFMILV 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 321 GMMFVGTVTSPAAAIALLCLGG-----FAHQTLsVTVITLcsDLFPHDQVATATGVSGTAANLGVLIF-TLSLGSMVDQI 394
Cdd:cd17345 311 IVALIVYWLAPNVLVDLIALIAlgfliYGPVML-IGLQAL--ELVPKKAAGTAAGLTGLFGYLGGSVLaTALIGIIVDHF 387
|
410 420
....*....|....*....|....
gi 695171606 395 GYQPFFIVL---GLLDLVGAALLW 415
Cdd:cd17345 388 GWNGGFIVLlasCILAIIFLALVA 411
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
22-345 |
7.44e-17 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 81.90 E-value: 7.44e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 22 ALFVVAMIINYLTRSILGVAAPAIMAEQHISSAQYSWITGAFQFGIM-FQPLAGYLLDVIGLKVGFTLFVAIWSCITLGH 100
Cdd:cd17328 2 AVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMvLSPIFGYLGDRYNRKWILAVGILIWSAATLLS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 101 GFANGWMGFAGLRGALGLVEGSAQPAGMKLVAEWFPARERGVAGGIYQIGASFGAVFAPPLVAW-AVFNHSWRAAFFVAG 179
Cdd:cd17328 82 SFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLvAQATGGWRWAFRVTG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 180 GLGLAWVVAWLAWYAPPQRHRRLSDGERTLIVAGQEAALVkhrrrpplgELLRKRNLWTIAAARFLADPVWGMLSLWMPL 259
Cdd:cd17328 162 VLGVLLAILLLLFVREPPRGAAEGGVMAKSTATSFLADLK---------ALAKNPSFILSTLGFTAVSFVTGALAFWAPT 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 260 YLVQARHFDLGQIALFAWLPFLAADLGCLFGPAVVAFLQRR---GVGLIDARRGAFT-LGAVLMTGMMFVGTVTSPAAAI 335
Cdd:cd17328 233 FFLRAFGVGDLSSADVGLIFGAITCIAGVLGVLLGGILADRlrrKTPRADPLVCAVGlLAAAPFLFLALVLALSNLLLAW 312
|
330
....*....|
gi 695171606 336 ALLCLGGFAH 345
Cdd:cd17328 313 VLLFLGEFLL 322
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
3-422 |
1.28e-16 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 81.07 E-value: 1.28e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 3 TLSRSGDVRRFPYIRWTIIALFVVAMIINYLTRSILGVAAPAIMAEQHISSAQYSWITGAFQFGIM-FQPLAGYLLDVIG 81
Cdd:COG2807 2 STTSSSARRSRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGlFAPLAPRLARRFG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 82 LKVGFTLFVAIWSCITLGHGFANGWMGFAGLRGALGLVEGSAQPAGMKLVAEWFPAReRGVAGGIYQIGASFGAVFAPPL 161
Cdd:COG2807 82 LERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 162 VAWAVFNHSWRAAFFVAGGLGLAWVVAWLAWYAPPQRHRRLSdgertlivagqeaalvkhRRRPPLGELLRKRNLWTIAA 241
Cdd:COG2807 161 TVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAA------------------PAAASLRSLWRSPLAWLLTL 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 242 ARFLADPVWGMLSLWMPLYLvQARHFDLGQIALFAWLPFLAADLGCLFGPAVVAFLQRRGVGLIdarrGAFTLGAVLMTG 321
Cdd:COG2807 223 FFGLQSLLYYAVVAWLPPIL-RDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLL----LLGLLGLAGLLG 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 322 MMFvGTVTSPAAAIALLCLGGFAHQTLSVTVITLCSDlfPHDQVATATGVSGTAANLGVLIFTLSLGSMVDQIG-YQPFF 400
Cdd:COG2807 298 LLL-APGSLPWLWAVLLGLGQGGLFPLALTLIGLRAR--TPAEAAALSGMAQSVGYLLAALGPLLVGALHDATGsWTAAL 374
|
410 420
....*....|....*....|..
gi 695171606 401 IVLGLLDLVGAALLWTLIRKAV 422
Cdd:COG2807 375 LLLAALAVLMLVAGLLAGRPYV 396
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
16-382 |
1.31e-16 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 81.14 E-value: 1.31e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 16 IRWTIIALFVVAMIINYLTRSILGVAAPAIMAEQ-HISSAQYSWITGAFQFG-IMFQPLAGYLLDVIGLKVGFTLFVAIW 93
Cdd:cd17327 2 LDLFILPLLCILYFLQYLDKSNISNAAVMGMKEDlKLVGNQYNWGNTVFYVGyIIFELPGNLLLQRFPPSKWLSVFIVLW 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 94 SCITLGHGFANGWMGFAGLRGALGLVEGSAQPAGMKLVAEWFPARERGVAGGIYQIGASFGAVFApPLVAWAVFNH---- 169
Cdd:cd17327 82 GLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFG-GLLAYGVFKIlgvg 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 170 ---SWRAAFFVAGGLGLAWVVAWLAWY-APPQRHRRLSDGERTLIV----AGQEAALVKHRRRPPLGELLRKRNLWTIAA 241
Cdd:cd17327 161 glaGWRWLFIIEGLITIIIGLVIFFWLpDNPSKAWFLTEEEKELAVerlrANQTGKGDQKFKWKQIKEAFKDPRTWLLFL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 242 ARFLADPVWGMLSLWMPLyLVQARHFDLGQIALFAwLPFLAADLGCLFgpaVVAFLQRRGvglidARRGAFTLGAVLMT- 320
Cdd:cd17327 241 FFFCSQITNNGISNFLPL-ILKSLGFYSLQTNLLS-VPIGALGAVSLL---IAALLSDRF-----KKRGLFAIFACVLAl 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 695171606 321 --GMMFVGTVTSPAAAIALLCLGGFAHQTLSVTVITLCSDLFPHDQVATATGVSGTAANLGVLI 382
Cdd:cd17327 311 vgSIILLAAPNPPGAYFAAYILGGGSYAGFPILLSWISSNCAGYTKRATVLAIMLIFYNVGNIV 374
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
20-415 |
2.07e-15 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 77.20 E-value: 2.07e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 20 IIALFVVAMIINYLTRSILGVAaPAIMAEQHISSAQYSWITGAFQFGIMF-QPLAGYLLDVIGLKVGFTLFVAIWSCITL 98
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLL-PDIARDFGVSVAQAGLLVSAYALGYALgALLLGPLSDRIERRRLLLVLLLLFILGNL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 99 GHGFANGWMGFAGLRGALGLVEGSAQPAGMKLVAEWFPARERGVAGGIYQIGASFGAVFAPPLVAWAVFNHSWRAAFFVA 178
Cdd:cd17324 80 LAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 179 GGLGLAwVVAWLAWYAPPQRHRRlsdgERTLIVAGQEAAlvkhrrrpplgeLLRKRNLWTIAAARFLADPVWGMLSLWMP 258
Cdd:cd17324 160 AVLALL-AALLLWRLLPSLPPKK----PGSLGLLSSLLL------------LLRNPRLRLAYLITFLLFGGFFALYTYLA 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 259 LYLVQARHFDLGQIALFawlpFLAADLGCLFGPAVVAFLQRRGVglidARRGAFTLGAVLMTGMMFVGTVTSPAAAIALL 338
Cdd:cd17324 223 PFLTDVPGFSSSAIIGL----LLLFGVAGVVGSPLAGRLADRGG----RRALLIALLLLAAALLLLTLLGPSPLLLLVGL 294
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 695171606 339 CLGGFAHQTLSVTVITLCSDLFPhDQVATATGVSGTAANLGVLIFTLSLGSMVDQIGYQPFFIVLGLLDLVGAALLW 415
Cdd:cd17324 295 VLWGLGFFAAHSALQTRVLRLAP-EARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
37-415 |
2.08e-14 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 73.79 E-value: 2.08e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 37 ILGVAAPAIMAEQ--HISSAQYSWITGAFQFGIMF-QPLAGYLLDVIGLKVGFTLFVAIWSCITLGHGFANGWMGFAGLR 113
Cdd:cd17316 17 LIGFVAPVLAAEFslGLSLLQTGLLFAAGFLGRPIgALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLR 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 114 GALGLVEGSAQPAGMKLVAEWFPARERGVAGGIYQIGASFGAVFAPpLVAWAVFNH-----SWRAAFFVAGGLGLawvva 188
Cdd:cd17316 97 FLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAA-LVASLLIPLlsgdwGWRILFLIGALPAL----- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 189 wlawyappqrhrrlsdgertlivagqeaalvkhrrrppLGELLRKRnLWTIAAARFLADPVWGMLSLWMPLYLVQARHFD 268
Cdd:cd17316 171 --------------------------------------LALLLRRR-TLLLILLWFFISFGYYGLTTFLPTYLQTVLGLS 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 269 LGQIALFAWLPFLAADLGCLFGPAVVAFLQRRGVGLIdarrgaFTLGAVLMTGMMFVGTVTSPAAAIALLCLGGFAHQTL 348
Cdd:cd17316 212 PATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVI------GLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGV 285
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 695171606 349 SVTVITLCSDLFPHDQVATATGVSGTAANLGVLIFTLSLGSMVDQIGYQPFFIVLGLLDLVGAALLW 415
Cdd:cd17316 286 WGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVA 352
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
17-297 |
5.63e-14 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 72.15 E-value: 5.63e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 17 RWTIIALFVVAMIINYLTRSILGVAAPAIMAEQHISSAQYSWITGAFQFG-IMFQPLAGYLLDVIGLKVGFTLFVAIWSC 95
Cdd:COG0477 12 RRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGrAIGLLLFGRLGDRYGRKRVLLIGLLLFGL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 96 ITLGHGFANGWMGFAGLRGALGLVEGSAQPAGMKLVAEWFPARERGVAGGIYQIGASFGAVFAPPLVAWAVFNHSWRAAF 175
Cdd:COG0477 92 ASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIF 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 176 FVAGGLGLawVVAWLAWYAPPQRHRRLSDGERTLIVAGQEAALVKHRRRPPLGELLRKRNLWTIAAARFLADPVWGMLSL 255
Cdd:COG0477 172 LINAPLGL--LALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLA 249
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 695171606 256 WMPLYLVQARHFDLGQIALFAWLPFLAADLGCLFGPAVVAFL 297
Cdd:COG0477 250 LLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLL 291
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
18-417 |
3.08e-13 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 70.68 E-value: 3.08e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 18 WTIIALFVVAMIINYLTRSILgvaaPAIMAEQHISSAQYSWITGAFQF-GIMFQPLAGYLLDVIGLKVGFTLFVAIWSCI 96
Cdd:cd17474 2 YAVFFATLLAVLGVSIVDPIL----PAIAEALGASPAQVGLLITAFTLpAAVLMPVAGVLADRFGRKKVLLPGLLLFGIG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 97 TLGHGFANGWMGFAGLRGALGLVEGSAQPAGMKLVAEWFPARERGVAGGIYQIGASFGAVFAPpLVAWAVFNHSWRAAFF 176
Cdd:cd17474 78 GLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGP-LLGGLLAAISWRYPFF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 177 VAGGLGLAWVVAWLAWYAPPQRHrrlsdgertlivagQEAALVKHRRRPplGELLRKRNLWTIAAARFLADPVWGMLSLW 256
Cdd:cd17474 157 LLAALIPVAFLAILFLLPEPKEK--------------AKSSSATKLRDL--KKALRGRGLLTFLVSAFLYFFLYFAFLTY 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 257 MPLYLVQARHFDLGQIALFAWLPFLAADLGCLFgpavVAFLQRRGVGLIDARRGAFTLGAVLMTGMMFVgtvTSPAAAIA 336
Cdd:cd17474 221 LPFLLELLYGISPIIIGLLFAGWSVLLALGSLF----VGRLLKKRFGARRILVIGLLLYALSLLLLGFV---PSLALLLI 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 337 LLCLGGFAHQTLSVTVITLCSDLFPHDQVATATGVSGTAANLGVLIFTLSLGSMVDQIGYQPFFIVLGLLDLVGAALLWT 416
Cdd:cd17474 294 AIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLAL 373
|
.
gi 695171606 417 L 417
Cdd:cd17474 374 L 374
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
21-379 |
7.14e-13 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 69.51 E-value: 7.14e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 21 IALFVVAMIInyltrSILGVAAPAIMAEQHISSAQYSWITGAFQFGI-MFQPLAGYLLDVIGLK----VGFTLFvAIWSC 95
Cdd:cd17321 3 LAVFLAALDV-----TIVNVALPTIARDLGASPSQLQWVVNAYLLAFaALLLLAGRLGDRFGRKrvflIGLALF-GLASL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 96 ITlghGFANGWMGFAGLRGALGLVEGSAQPAGMKLVAEWFPARERGVAGGIYQIGASFGAVFAPPLVAWAVFNHSWRAAF 175
Cdd:cd17321 77 LC---ALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIF 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 176 FVAGGLGLawVVAWLAwyappqrhrrlsdgertlivagqeaalvkhrrrpplgellrkRNLWTIAAARFLADPVWGMLSL 255
Cdd:cd17321 154 LINVPIGL--VALLLA------------------------------------------RTFSGAVLAAFLLGAALGGLLF 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 256 WMPLYLVQARHFDLGQIALfAWLPFLAADLgcLFGPAVVAFLQRRGVGLIdaRRGAFTLGAVLMTGMMFVGTVTSPAAAI 335
Cdd:cd17321 190 LLPLYLQGVLGYSPLQAGL-ALLPLALAML--VAAPLAGRLADRFGPRLV--LVAGLLLTAVGLLLLALLGADSSVWLLL 264
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 695171606 336 ALLCLGGFAHQTLSVTVITLCSDLFPHDQVATATGVSGTAANLG 379
Cdd:cd17321 265 PGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLG 308
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
25-417 |
1.70e-12 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 68.39 E-value: 1.70e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 25 VVAMIINYLTRSILGVAAPAIMAEQHISSAQYSWITGAFQFGIMF-QPLAGYLLDVIGLKVGFTLFVAIWSCITLGHGFA 103
Cdd:cd17489 2 LLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLaRPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 104 NGWMGFAGLRGALGLVEGSAQPAGMKLVAEWFPARERGVAGGIYQIGASFGAVFAPPLVAWAVFNHSWRAAFFVAGGLGL 183
Cdd:cd17489 82 TSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 184 -AWVVAWLAWYAPPQRHRRLSDGERTLIVagqeaalvkhrrrpplgelLRKRNLWTIAAARFLADPVWGMLSLWMPLYlv 262
Cdd:cd17489 162 lALLLVFLVKDPPPVAAEEAEAGTRAFRR-------------------LVEKKVLPPALILFLASIAYGAISTFLPLY-- 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 263 qARHFDLGQIALFawlpFLAAdlgclfgpAVVAFLQRRGVG-LIDARRGAFTL---GAVLMTGMMFVGTVTSPAAAIALL 338
Cdd:cd17489 221 -AAERGISNAGLF----FTVY--------AIALLLSRPFSGkLSDRKGPKTVIipgLLLLALGLLLLSFAGSPWMLLLAA 287
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 695171606 339 CLGGFAHQTLSVTVITLCSDLFPHDQVATATGVSGTAANLGVLIFTLSLGSMVDQIGYQPFFIVLGLLDLVGAALLWTL 417
Cdd:cd17489 288 VLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFL 366
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
52-410 |
1.77e-12 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 68.62 E-value: 1.77e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 52 SSAQYSWITGAFQFGIMF-QPLAGYLLDVIGLK--VGFTLFVAIWSCITLGHGFANGWMGFAGLRGALGLVEGSAQPAGM 128
Cdd:TIGR00894 74 SGALQGLILSSHFYGQIIiQIPVGYLAGKYVFKwsIGIGMFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGSVSPATH 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 129 KLVAEWFPARERGVAGGIYQIGASFGAVFAPPLVAW-AVFNHSWRAAFFVAGGLGLAWVVAWLAWYAP-PQRHRRLSDGE 206
Cdd:TIGR00894 154 KIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWlCESWGGWPMIFYVFGIVGCAWSLLWFVFPADdPSIHPCISKFE 233
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 207 RTLIVAGQEAALVKHRRRPPLGELLRKRNLWTIAAARFLADPVWGMLSLWMPLYLVQARHFDLGQIALFAWLPFLAADLG 286
Cdd:TIGR00894 234 KKYINSSLQGQKGSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLC 313
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 287 CLFGPAVVAFLQRRGVGLIDARRGAFTLGAVLMTGMMFVGTVTSPAA---AIALLCLGGfahqtlSVTVITLCSDLFPHD 363
Cdd:TIGR00894 314 SIFAGYLADFLKSSKTLSLTAARKIFNGIGGLGPGIFAYALPYLSAAfylTIIILTLAN------AVSSGPLAGVLINSL 387
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 695171606 364 QVATA-----TGVSGTAANLGVLIFTLSLGSMVDQIGYQPFFIVLGLLDLVG 410
Cdd:TIGR00894 388 DLAPRflgfiKGITGLPGFIGGLIASTLAGNILSQDSKNVWLIVFLIMAFVN 439
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
48-417 |
2.05e-12 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 68.02 E-value: 2.05e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 48 EQHISSAQYSWITGAFQF-GIMFQPLAGYLLDVIGLKVGFTLFVAIWSCITLGHGFANGWMGFAGLRGALGLVEGSAQPA 126
Cdd:cd17329 29 QLGLSASIVGLVLALSAVaGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 127 GMKLVAEWFPARERGVAGGIYQIGASFGAVFAPPLVAWaVFNHSWRAAFFVAGGLGLAwVVAWLAWYAPPQRHRRlsdge 206
Cdd:cd17329 109 SEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGL-LLLYSFRLLFLAAAVLFLL-AALVLLFLLPETRPKR----- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 207 rtlivagqeAALVKHRRRPPLGELLRKRNLWTIAAARFLADPVWGMLSLWMPLYLVQARHFdlgQIALFAWLPFLAADLG 286
Cdd:cd17329 182 ---------RAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGL---GESLLGLLLALNALLI 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 287 CLFGPAVVAFLQRRGvglidaRRGAFTLGAVLMT-GMMFVGTVTSPAAAIALLCLGGFAHQTLSVTVITLCSDLFPHDQV 365
Cdd:cd17329 250 VLLQFPVARLVERFR------LRKILMIGILLFAiGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKR 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 695171606 366 ATATGVSGTAANLGVLIFTLSLGSMVDQIGYQPFFIVLGLLDLVGAALLWTL 417
Cdd:cd17329 324 GSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGL 375
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
17-417 |
3.27e-12 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 67.64 E-value: 3.27e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 17 RWTIIALFVVAMIINYLTRSILGVAAPAIMAEQHISSAQYSWI-TGAFQFGIMFQPLAGYLLDVIGLK----VGFTLFVA 91
Cdd:cd17353 1 RRWLVLLGAVLMHLILGYQYAWSVFNPPLSSALGWSLASVALAfTLTIVFLAISAPFAGRLVDRGGPRkailIGGILFGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 92 IWSCITLGHGFANGWMGFAGLRGA-LGLVEGSAQPAGMKlvaeWFPAReRGVAGGIYQIGASFGAVFAPPLVAwAVFNHS 170
Cdd:cd17353 81 GFILSAFAISLPLLFLGYGVLGGIgAGIGYITPVSTAVK----WFPDK-RGLATGIVIAGFGLGSLIFSPLIA-YLINTV 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 171 WRAAFFVAGGLGLAWVVAWLAWYA--PPQRhrrLSDGERTLIVAGQEAALVKHRRRpplgELLRKRNLWTIAAARFLADP 248
Cdd:cd17353 155 GVPTTFLILGIIFLIIIVIGAFLIrdPPKG---WVPPGVDPLANNAENSPRDYTPR----EMLRTPTFWLLWLMFFLNAT 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 249 VWGMLSLWMPLYLVQARHFDLGQIALFAWLPFLAADLGCLFGPAVVAFLQRRGVGLIdarrgAFTLGAVLMTGMMFVGTV 328
Cdd:cd17353 228 AGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSI-----AFLIQGVAMFLLPFIGSV 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 329 tsPAAAIALLCLGGFAHQTLSVTVITLCSDLFPHDQVATATGVSGTAANLGVLIFTLSLGSMVDQIGYQPFFIVLGLLDL 408
Cdd:cd17353 303 --AVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSL 380
|
....*....
gi 695171606 409 VGAALLWTL 417
Cdd:cd17353 381 VALALALLL 389
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
21-421 |
4.85e-12 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 66.84 E-value: 4.85e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 21 IALFVVAMIINYLTRSILGVAAPAIMAEQHISSAQYSWITGAFQFGIMFQPL-AGYLLDVIGLKVGFTLFVAIWSCITLG 99
Cdd:cd17365 1 LALCFLIIVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALlAGPLADRFGRKRVLLVSVALFGLFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 100 HGFANGWMGFAGLRGALGLVEGSAQPAGMKLVAEWFPARERGVAGGIYQIGASFGAVFAPPLVAWAVFNHSWRAAFFVAG 179
Cdd:cd17365 81 TAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 180 GLGLAWVVAWLAwyappqrhrrlsdgerTLivagqeaalvkhrrrpplgellrkrnlwTIAAARFLADPVWGMLSLWMPl 259
Cdd:cd17365 161 VPPLILLPLLRG----------------TL----------------------------LLWVTFFMGLLLVYLLNSWLP- 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 260 YLVQARHFDLGQIALFAWLPFLAADLGCLFGPAVVAFLQRRGVGLIdarrgaFTLGAVLMTGMMFVGTVTSPAAAIALLC 339
Cdd:cd17365 196 KLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLAL------FFALGAVSLALLGVSPASLVLLYVLVFL 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 340 LGGFAHQTLSVtVITLCSDLFPHDQVATATGVSGTAANLGVLIFTLSLGSMVD-QIGYQPFFIVLGLLDLVGAALLWTLI 418
Cdd:cd17365 270 AGACVNGAQVG-LYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLAaGLGPESVFLALAIPAALGALAVLLLR 348
|
...
gi 695171606 419 RKA 421
Cdd:cd17365 349 LRR 351
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
25-379 |
1.23e-11 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 65.68 E-value: 1.23e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 25 VVAMIINYLTRSILGVAAPAIMAEQHISSAQYSWITGAFQFG-IMFQPLAGYLLDVIGLKVGFTLFVAIWSCITLGHGFA 103
Cdd:cd17503 2 LLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLAlAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 104 NGWMGFAGLRGALGLVEGSAQPAGMKLVAEWFPARERGVAGGIYQIGASFGAVFAPPLVAWAVFNHSWRAAFFVAGGLGL 183
Cdd:cd17503 82 PNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 184 AWVVAwlawyappqrhrrlsdgertlivagqeAALVKHRrrpplgeLLRKRNLWTIAAARFLADPVWGMLSLWMPLYLVQ 263
Cdd:cd17503 162 LALLL---------------------------APLLDLR-------LFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQN 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 264 ARHFDLGQIALFAwlpFLAADLGCLFGPAVVAFLQRRGVGLIDArrGAFTLGAVLMTGMMFVGTVTSPAAAIALLCLGGF 343
Cdd:cd17503 208 VLGYSAFESGLVL---APGGLASAILSPLVGRLLDKFGPRLLLL--AGLLLLALGTLLLAFLTPDTSLWLIILPLFIRGL 282
|
330 340 350
....*....|....*....|....*....|....*.
gi 695171606 344 AHQTLSVTVITLCSDLFPHDQVATATGVSGTAANLG 379
Cdd:cd17503 283 GMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLG 318
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
36-414 |
2.69e-11 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 64.63 E-value: 2.69e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 36 SILGVAAPAIMAEQHISSAQYSWI-TGAFQFGIMFQPLAGYLLDVIGLKVGFTLFVAIWSCITLGHGFANGWMGFAGLRG 114
Cdd:cd17371 16 LLLGLVLPALIAEFGLDEAEAGLLgTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRA 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 115 ALGLVEGSAQPAGMKLVAEWFPARERGVAGGIYQIGASFGAVFA----PPLVAWAVFNHSWRAAFFVAGglglawVVAWL 190
Cdd:cd17371 96 LAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLAtllaALLFPLLPPEIAWRVLFLLGA------LPALL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 191 AWYAppqrHRRLSDGERTLIVagqEAALVKHRRRPPLGELLRKRNLWTIAAARFLADPVWG---MLSLWMPLYLVQARHF 267
Cdd:cd17371 170 VLFI----RRFVKEPPQWQAA---RAARRHFADRPSLRELFSPPLLRTTLLASLLATGALGgyyGITTWLPSYLTGERGL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 268 DLGQIALFAWLPFLAADLGCL-FGPAVVAFLQRRGVGLidarrgaFTLGAVLMTGMMFVGTVTSPAAAIALLCLGGFAHQ 346
Cdd:cd17371 243 SFEGSAGYLVVTILGGFLGYLaGGFLADRIGRRNNFAL-------FALGSAISILLYFFLPLSPTLILILGFPLGFFASG 315
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 695171606 347 TLSVTVITLcSDLFPHDQVATATGVSGTAANLGVLIFTLSLGSMVDQIGYQPFFIVLGL---LDLVGAALL 414
Cdd:cd17371 316 PFSGMGAYL-TELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATSGSLGTAIAVFAAvyyIAGLVLALL 385
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
36-415 |
3.77e-11 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 64.11 E-value: 3.77e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 36 SILGVAAPAIMAEQHISSAQYSWITGAFQFGI-MFQPLAGYLLDVIGLKVGFTLFVAIWSCITLGHGFANGWMGFAGLRG 114
Cdd:cd17478 13 GFLPALLPLLIAKLGLSYAQAGLLVSVFSITSsLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 115 ALGLVEGSAQPAGMKLVAEWFPAReRGVAGGIYQIGASFGAVFAPPLVAWAVFNHSWRAAFFVAGGLGLAWVVAWLAWYA 194
Cdd:cd17478 93 LAGIGSAAFHPEGARLASQAAGGR-RGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRP 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 195 PPQRHRRLSDgertlivAGQEAALVKHRRRPPLGellrkrNLWTIAAARfladpVWGMLSL--WMPLYLVQaRHFDLGQI 272
Cdd:cd17478 172 LKKPEAKKAA-------AKSSARSTLKGVWRALL------LLLIIVFLR-----SWVLSSLttFLPFYLVQ-RGYSLVFA 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 273 ALFAWLPFLAADLGCLFGPAVVAFLQRRGVGLIdarrgaFTLGAVLMTGMMFVgtVTSPAAAIALLCLGGFAHQTLSVTv 352
Cdd:cd17478 233 GLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIA------SLLLAAPFLLLFLL--TPGIWSYILLVLAGFLLFASFPVT- 303
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 695171606 353 ITLCSDLFPhDQVATATGVSGTAANLGVLIFTLSLGSMVDQIGYQPFFIVLGLLDLVGAALLW 415
Cdd:cd17478 304 VVLAQELLP-GNVGLASGLMMGLSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
58-344 |
1.86e-10 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 62.10 E-value: 1.86e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 58 WITGAFQFG-IMFQPLAGYLLDVIGLK--VGFTLF-VAIWSCIT-LGHGFANGWMgfAGLRGALGLVEGSAQPAGMKLVA 132
Cdd:cd17381 69 WILGSFFYGyIITQIPGGYLASKIGGKllLGFGILgTAVFTLLTpLAADLGAGYL--IAVRALEGLGEGVTFPAMHAMWA 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 133 EWFPARERGVAGGIYQIGASFGAVFAPPLVAWAVFNHSWRAAFFVAGGLGLAWVVAWLaWYAPPqrhrrlsdgertliva 212
Cdd:cd17381 147 SWAPPLERSRLLTISYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLWI-WLVMP---------------- 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 213 gqeaalvkhrrrpplgellrkrnLWTIAAARFLADPVWGMLSLWMPLYLVQARHFDLGQIALFAWLPFLAADLGCLFGPA 292
Cdd:cd17381 210 -----------------------LWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWLFMILSGQ 266
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 695171606 293 VVAFLQRRGVGLIDARRGAFTL-----GAVLMTGMMFVGTVTSPAAAIALL--CLGGFA 344
Cdd:cd17381 267 IADNLREKQNFSTVCVRKIFTLigmigPAVFLLAAGFTGCNYSLAVAFLTIssTLGGFS 325
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
17-418 |
6.16e-10 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 60.50 E-value: 6.16e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 17 RWTIIALFVVAMIINYLTRSILGVAAPAIMAEQHISSAQYSWITGAFQF--GIMfQPLAGYLLDVIGLKVGFTLFVAIWS 94
Cdd:cd17488 1 RIHILASMFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYItyGVS-KFVSGLMSDRSNPRYFMGIGLIATG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 95 CITLGHGFANGWMGFAGLRGALGLVEGSAQPAGMKLVAEWFPARERGVAGGIYQIGASFGAVFAPPLVAWAVFNHSWRAA 174
Cdd:cd17488 80 IINILFGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTYGWRAG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 175 FFVAGGLGLAwVVAWLAWyappqrhrRLSDgertlivagqeaalvkhrrRPPLgellrkrnLWTIAAARFLADPVWGMLS 254
Cdd:cd17488 160 MYVPGIIAIL-MGIVLCW--------RLRD-------------------RPPY--------IWLLAFCYVLVYVVRTAIN 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 255 LWMPLYLVQARHFDL----GQIALFawlpflaaDLGCLFGPAVVAFL-------QRRGVGLIdarrgaFTLGAVLMTGMM 323
Cdd:cd17488 204 DWGNLYLSETHGYSLvkanSAVSLF--------EVGGLIGALVAGWGsdklfkgNRGPMNLI------FALGLLVSVGAL 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 324 FVGTVTSPAAAIALLCLGGFAHQTLSVTVITLCSDLFPHDQVATATGVSGTAANLGVLIFTLSLGSMVDQIGYQPFFIVL 403
Cdd:cd17488 270 WLVPVHSYWLLATCFFTIGFFVFGPQMLIGMAAAECSHKDAAGSATGFVGLFAYLGAALAGYPLAKVIESWGWSGFFIVI 349
|
410
....*....|....*
gi 695171606 404 GLLDLVGAALLWTLI 418
Cdd:cd17488 350 SIAAAISGLLLLPLL 364
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
29-413 |
1.59e-09 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 59.26 E-value: 1.59e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 29 IINYLTRSILGVAAPAIMAEQHISSAQYSWITGAFQFGIMFQPL-AGYLLDVIGLKVGFTLFVAIWSCITLGHGFANGWM 107
Cdd:cd17333 6 FSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLlAGFLMKRLGRRRTLILGLLLISLALALIFATPSIY 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 108 GFAGLRGALGLVEGSAQPAGMKLVAEWFPaRERGVAGGIYQIGASFGAVFAPPLVAWAVFNH-SWRAAFFVAGGLGLAWV 186
Cdd:cd17333 86 LFVVLMFLAGLGAGILDTGANTFVGALFE-ESSATRLNVLHGFFGLGALIGPLIATSLLTSElSWSWAYLIIGLIYLLLA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 187 VAWLAWYAPPQRHRRLSDGERTLIVagqeaalvkhrrrPPLGELLRKRNLWTIAAARFLADPVWGMLSLWMPLYLVQARH 266
Cdd:cd17333 165 ILILLTLFPELPSARNPQQSVGAFS-------------ASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKH 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 267 FDLGQIALFAWLPFLAADLGCLfgpaVVAFLQRRgvglIDARRGAFTLGAVLMTGMMFVGTVTSPAAAIALLCLGGFAHQ 346
Cdd:cd17333 232 VSDGLAGYLLSGFWVGITIGRL----LGGPISRR----IKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMA 303
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 695171606 347 TLSVTVITLCSDLFPHdQVATATGVSGTAANLGVLIFTLSLGSMVDQIGYQPFFIVLGLLDLVGAAL 413
Cdd:cd17333 304 ALFPTILSLGISNLPY-AKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIFVL 369
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
85-349 |
1.85e-09 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 58.89 E-value: 1.85e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 85 GFTLFVAIWSCITLGHGFANGWMGFAGLRGALGLVEGSAQPAGMKLVAEWFPARERGVAGGIYQIGASFGAVFAPPLVAW 164
Cdd:cd17382 83 GLAIFVTSTLNMLIPIAARVHYGCVIFVRILQGLVEGVTYPACHGIWRKWAPPLERSRLATTAFCGSYAGAVVGMPLSGI 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 165 AVFNHSWRAAFFVAGGLGLAWVVAWLaWYAPPqrhrrlsdgertlivagqeaalvkhrrrpplgellrkrnLWTIAAARF 244
Cdd:cd17382 163 LVQYVGWSSPFYVYGVFGIIWYMFWM-LVSMP---------------------------------------VYAIIVANF 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 245 LADPVWGMLSLWMPLYLVQARHFDLGQIALFAWLPFLAADLGCLFGPAVVAFLQRRGVGLIDARRGAFTLGAVLMTGMMF 324
Cdd:cd17382 203 CRSWTFYLLLISQPAYFKEVFGFDISKVGILSALPHLVMTIIVPIGGQLADYLRSRGILSTTAVRKIFNCGGFGMEATFL 282
|
250 260
....*....|....*....|....*...
gi 695171606 325 --VGTVTSPAAAIALLCLG-GFAHQTLS 349
Cdd:cd17382 283 lvVAFSHSPTVAISFLVLAvGFSGFAIS 310
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
25-190 |
2.25e-09 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 58.93 E-value: 2.25e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 25 VVAMIINYLTRSILGVAAPAIMAEQHISSAQYSW-ITGAFQFGIMFQPLAGYLLDVIGLKVGFTLFVAIWSCITLGHGFA 103
Cdd:TIGR00711 8 MLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWvITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 104 NGWMGFAGLRGALGLVEGSAQPAGMKLVAEWFPARERGVAGGIYQIGASFGAVFAPPLVAWAVFNHSWRAAFFVAGGLGL 183
Cdd:TIGR00711 88 PNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGI 167
|
....*...
gi 695171606 184 -AWVVAWL 190
Cdd:TIGR00711 168 iVVVVAFF 175
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
22-384 |
7.64e-09 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 57.64 E-value: 7.64e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 22 ALFVVAMIINYLTRSILGVAAPAIMAEQHiSSAQYSWITGAFQFGI-MFQPLAGYLLDVIGLK---VGFTLFVAIWSCIT 97
Cdd:cd06179 1 AALCLAYFAQLFGVTLPAAVLPFIVADLG-PSSNSTWISTAWSLAQaVLGPIVGRLSDLFGRRwffIGGNLLGVVGSIVA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 98 lghGFANGWMGFAGLRGALGlVEGSAQPAGMKLVAEWFPARERGVAGGIYQIGASFGAVFAPPLVAWAVFNH--SWRAAF 175
Cdd:cd06179 80 ---GTAKSVNMLIGGQALIG-IGAGTQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANaaGWRWIF 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 176 FVAGGLGLAWVVAWLAWYAPPQRHRRLSDGER------------------------------------------------ 207
Cdd:cd06179 156 YINAIFNALALILLFFFYHPPPRPQLHGSSTRqklkrldwvglflliaglvlfllglswggnpypwssahviaplviggv 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 208 TLIVAGQEAALVKHRRRPPLGELLRKRNLWTIAAARFLADPVWGMLSLWMPLYLVQARHFDLGQIALFawlpFLAADLGC 287
Cdd:cd06179 236 LLIAFGLYEWKGTKDGLLPPRLLFRGRNFALILIVAFVEGMIFYSLNIFWPQQISLLFTTDPLKAGLY----QLPFGLGT 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 288 LFGPAVVAFLQRRGVGLidarRGAFTLGAVLMT---GMMFVGTVTSPAAAIALLCLGGFAH---QTLSVTVITLCSdlfP 361
Cdd:cd06179 312 LFGAILAGLLLTKIKHI----KWQLVAGFVLFTaflALLALITPDNKALAIAFSVLAGIGIggpLVLAIVIVQLSV---P 384
|
410 420
....*....|....*....|...
gi 695171606 362 HDQVATATGVSGTAANLGVLIFT 384
Cdd:cd06179 385 PEDIGTASGLLGSARALGGAVGT 407
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
24-379 |
1.43e-08 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 56.05 E-value: 1.43e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 24 FVVAMIINYLTRSILGVAAPAIMAEQHISSAQYSWI-TGAFQFGIMFQPLAGYLLDVIGLKVGFTLFVAIWSCITLGHGF 102
Cdd:cd17504 1 LALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVlTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 103 ANGWMGFAGLRGALGlVEGSAQPAGMKLVAEWFPARERGVAGGIYQIGASFGAVFAPPLVAWAVFNHSWRAAFFVAGGLG 182
Cdd:cd17504 81 APNLPVLIAGRALQG-IGGAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 183 LAWVVAwlawyappqrhrrlsdgertlivagqeAALVKHRrrpplgeLLRKRNLWTIAAARFLADPVWGMLSLWMPLYLV 262
Cdd:cd17504 160 VLLAAL---------------------------VPLIDLR-------LLRRRNVLLANITALLAGFGMFMVFQLLPQLLQ 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 263 QARHFDLGQIALFAWLPFLAADLGCLFGPAVVAFLQRRgvglIDARRgAFTLGAVLMTG--MMFVGTVTSPAAAIALLCL 340
Cdd:cd17504 206 LPTPTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIAR----VGPRR-VLLIGLVISAVglLLLALLHSSLWALVVALLL 280
|
330 340 350
....*....|....*....|....*....|....*....
gi 695171606 341 GGFAHQTLSVTVITLCSDLFPHDQVATATGVSGTAANLG 379
Cdd:cd17504 281 IGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIG 319
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
17-417 |
3.00e-08 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 55.42 E-value: 3.00e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 17 RWTIIALFVVAMIINYLTRSILGVAAPAIMAEQHISSAQYSWITGA--FQFGIMfQPLAGYLLDVIGLKVGFTLFVAIWS 94
Cdd:cd17343 1 QLTIFASMFVGYTLYYFNRKSFSFVLPSLMNELGLDKSDLGLITSSqsLAYAIS-KFIGGVLSDQISARWLFSSGLVLSG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 95 CITLGHGFANGWMGFAGLRGALGLVEGSAQPAGMKLVAEWFPARERGVAGGIYQIGASFGAVFAPPLVAWAVFNHSWRAA 174
Cdd:cd17343 80 LTTVAFSGSSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSYGWRST 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 175 FFVAGGLGLAWVVAWLAWYappqrhrRLSDGERTLIVAGQEAALVKH----RRRPPLGELLRKRNLWTIAAARFLADPVW 250
Cdd:cd17343 160 LSISGTVAVVMSVVCLLFI-------KNEPSDVGLNNIEEEESKGKKkkspRGESTLKELLLSPFLWLLSLGYLVVFGVK 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 251 GMLSLWMPLYLVQarhfDLGQIALFAWLPFLAADLGCLFGPAVVAFLQRRGV---GLIDARRGAFTLGAVLMTGM----- 322
Cdd:cd17343 233 TAVTDWGQLFLIQ----DKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDWAVakhGSSSRGNPRMPLALVFMAGLtvslh 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 323 MFVGTVTSPAAAIALLCLGgFAHQTLSVTVITL----CSDLFPHDQVATATGVSGTAANLGVLIFTLSLGSMVDQIGYQP 398
Cdd:cd17343 309 LFRVHITSDSSELFILLLG-FLIGFSLYGPIAIfgviANESAPSHLCGTSHAIVALAANVGGVLAGLPFSYIAKHYDWRT 387
|
410
....*....|....*....
gi 695171606 399 FFIVLGLLDLVGAALLWTL 417
Cdd:cd17343 388 AFLLLEILCAITVVILFLL 406
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
18-417 |
1.61e-07 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 53.04 E-value: 1.61e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 18 WTIIALFVVAMIINYLTRSILGVAAPAIMAEQHISSAQYSW-ITGAFQFGIMFQPLAGYLLDVIGLKVgftlfVAIWSCI 96
Cdd:cd17355 2 WVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLaFTVGLLAFGLAQPFVGRLLDRFGPRR-----VMLLGLL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 97 TLGHGFA------NGWMGFAGLRGALGLVEGSAQPAGMKLVAEWFPARERGVAGGIYQIGASFGAVFAPPLVAWAVFNHS 170
Cdd:cd17355 77 LLAAGLVllalatSLWQLYLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 171 WRAAFFVAGGLGLawVVAWLAWYAPpqrHRRLSDGERTLIVAGQEAALvkhrrRPPLGELLRKRNLWTIAAARFLADPVW 250
Cdd:cd17355 157 WRTALLVLALLAL--LVLVPVLLLL---RRRPADLALRAYDDASPASP-----GSTLKEALRSASFWLLALAFFLCGFAV 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 251 GMLSLWMPLYLVQARhfdlgqialfaWLPFLAADLGCLFGpaVVAFLQRRGVGLIDAR------RGAFTLGAVLMTGMMF 324
Cdd:cd17355 227 VGLIVHLVPYLADRG-----------ISPAAAAVALALIG--LFNIVGRLLSGWLGDRysprrlLAASYALRALGLALLL 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 325 VGTVTSPAAAIALLCLGGFAHQTLSVTViTLCSDLFPHDQVATATGVSGTAANLGVLIFTLSLGSMVDQIG-YQPFFIVL 403
Cdd:cd17355 294 LLPFPPLALLLFAALFGLGWGATVPLTA-ALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGsYTAAWALA 372
|
410
....*....|....
gi 695171606 404 GLLDLVGAALLWTL 417
Cdd:cd17355 373 VALGLIAALLVLPI 386
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
18-198 |
2.38e-07 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 52.56 E-value: 2.38e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 18 WTIIALFVVAMIINYLTRSILGVAAPAIMAEQHISSAQYSWITGAFQFGIMF-QPLAGYLLDVIGLKVGFTLFVAIWSCI 96
Cdd:COG2271 180 LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVgSLLGGWLSDRLGRRRKLVLAIGLLLAA 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 97 --TLGHGFANGWMGFAGLRGALGLVEGSAQPAGMKLVAEWFPARERGVAGGIYQIGASFGAVFAPPLVAWAVFNHSWRAA 174
Cdd:COG2271 260 laLLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAA 339
|
170 180
....*....|....*....|....
gi 695171606 175 FFVAGGLGLAWVVAWLAWYAPPQR 198
Cdd:COG2271 340 FLLLAALALLAALLALLLLRETRK 363
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
46-414 |
4.56e-07 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 51.41 E-value: 4.56e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 46 MAEQHISSAQYSWITGAFQFGIM-FQPLAGYLLDVIGLKVGFTLFVAIWSCITLGHGFANGWMGFAGLRGALGLVEGSAQ 124
Cdd:cd17477 23 LEREGVSTALIGLVASAYYLGILlGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLF 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 125 PAGMKLVAEWFPARERGVAGGIYQIGASFGAVFAPPLVAWAVfNHSWRAAFFVAGGLGLAWVVAWLAWYAPPQRHRRLSD 204
Cdd:cd17477 103 VVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVG-TAGALPFLIAAVLLLLALVPLLLTRRAAPEIEEAESI 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 205 GERTLIvagqeaalvkhrRRPPLGellrkrnLWTIAAARFLADPVWGMlslwMPLYLVQArHFDLGQIALFAWLPFLAAD 284
Cdd:cd17477 182 SLRRLL------------RIAPLA-------LLGAFVAGFLEGAFYSL----LPLYGLRL-GLSVAQAALLLAAFVLGGL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 285 LGCLFGPAVVAFLQRRGVGLIDArrgafTLGAVLMTGMMFVGTvTSPAAAIALLCLGGFAHqTLSVTVITLCSDLFPHDQ 364
Cdd:cd17477 238 LLQWPLGWLADRFDRRRVLLGCA-----LLGALAALLLPLVPG-LPLALLVLLFLWGGAAG-PLYTLALALAGDRLPGDE 310
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 695171606 365 VATATGVSGTAANLGVLIFTLSLGSMVDQIGYQPFFIVLGLLDLVGAALL 414
Cdd:cd17477 311 LVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
37-200 |
4.71e-07 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 51.42 E-value: 4.71e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 37 ILGVAAPAIMAEQHISSAQYSWITGAFQ-FGIMFQPLAGYLLDVIGLKVGFTLFVAIWSCITLGHGFANG-WMGFAGLRG 114
Cdd:COG2223 224 FSSWLPPYLVDQFGLSAATAGLLAALFAlLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGsLWLFLVLFL 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 115 ALGLVEGSAQPAGMKLVAEWFPARERGVAGGIYQIGASFGAVFAPPLVAWAV-FNHSWRAAFFVAGGLGLAWVVAWLAWY 193
Cdd:COG2223 304 LLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLdATGSYTAAFLVFAVLALVALVLTLLLY 383
|
....*..
gi 695171606 194 APPQRHR 200
Cdd:COG2223 384 RRPRRAA 390
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
67-417 |
5.28e-07 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 51.42 E-value: 5.28e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 67 IMFQPLAGYLLDVIGLKVGFTLFVAIWSCITLGHGFANGWMGFAGLRGALGLVEGSAQPAGMKLVAEWFPARERGVAGGI 146
Cdd:cd17473 49 ALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGL 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 147 YQIGASFGAVFAPPLVAWAVfNHSWRAAFFVaggLGLAWVVAWLAWYAPPqrhrrlsDGERTLIVAGQEAALVKHRrrpp 226
Cdd:cd17473 129 QSAAMSLGGVVFLLLGGALA-EIGWRAPFLV---YLLALPVLILVLLFLP-------EPARKSKSAASPGAATAAA---- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 227 lgelLRKRNLWTIAAARFLADPVWGMLSLWMPLYLVQARHFDLGQIALFAWLPFLAAdlgclfgpAVVAFLQRRGVGLID 306
Cdd:cd17473 194 ----LPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAG--------AIGALLFGRLKRRLG 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 307 ARRGAFTLGAVLMTGMMFVGTVTSPAAAIALLCLGGFAHQTLSVTVITLCSDLFPHDQVATATGVSGTAANLGVLIFTLS 386
Cdd:cd17473 262 KRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLV 341
|
330 340 350
....*....|....*....|....*....|..
gi 695171606 387 LGSMVDQI-GYQPFFIVLGLLDLVGAALLWTL 417
Cdd:cd17473 342 LGPLVNLTgGLSGAFLILGVLALVLAIVLLLL 373
|
|
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
135-415 |
1.23e-06 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 50.30 E-value: 1.23e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 135 FPARERGVAGGIYQIGASFGAVFAPPLVAWAVFNHSWRAAFFV-AGGLGLAWVVAWLAWYAPPQRHRRLSDGERtlivag 213
Cdd:cd17485 121 LTPEERGLGNAAQVVGYKLGSLLGGGGLLWLYDLIGWQSLLLSlAALYLLLLLPVLFLRELELPQQPPASERGA------ 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 214 qeaalvkhRRRPPLGELLRKRNLWTIAAARFLADPVWGMLSLWMPLYLVQaRHFDLGQIALfaWLPFLAADLGcLFGPAV 293
Cdd:cd17485 195 --------ALKASLRAFLRRPGTRWLLLFLLLYKLGEQGALAMLPPFLVD-RGFSLSQIGL--LSGVGGSLVS-IAGSLL 262
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 294 VAFLQRRgVGLIDARRGAFTLGAVLMTGMMFVGTVTSPA------AAIALLCLGGFAHQTLSVTVITLCSDLfphDQVAT 367
Cdd:cd17485 263 GGYLLKR-RGRRRLLLLGGLLRLLLLGLYTLLALGGSGLnwvlllASLALLHLVGGMITTALFTLMMDCSQQ---AQAGT 338
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 695171606 368 ATGVSGTAANLGVLIFTLSLGSMVDQIGYQPFFIVLGLLDLVGAALLW 415
Cdd:cd17485 339 DYTLLATVEVLGKLLFGSLAGFLADHLGYAAAFLLFAILSALSVLLLL 386
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
23-417 |
1.60e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 49.92 E-value: 1.60e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 23 LFVVAMIINYLTRSILGVAAPAIMAEQHISSAQYSWITGAFQF-GIMFQPLAGYLLD-------VIGLKVGFTLFVAIWs 94
Cdd:cd06173 3 LLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLpFLLFSPFAGVLADrfdrrrlLILADLLRALLAAVL- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 95 CITLGHGFANGWMGFAGLrGALGLVEGSAQPAGMKLVAEWFPARERGVAGGIYQIGASFGAVFAPPLVAWAVFNHSWRAA 174
Cdd:cd06173 82 ALLALLGSLSLWLLLVLA-FLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 175 FFVAGGLGLAwvVAWLAWYAPPQRHRRLSDGERTLIVAGQEAALVKHRRRPplgellrkrnLWTIAAARFLADPVWGMLS 254
Cdd:cd06173 161 FAINALSFLL--SALLLLFIRRPPPAAPGESSSLLLRDLREGLRYLRRSPL----------LRLLLLALALFALLGGALT 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 255 LWMPLYLVQARHFDLGQIALFawlpFLAADLGCLFGPAVVAFLQRRgvglIDARRGAFTLGAVLMTGMMFVGTVTSPAAA 334
Cdd:cd06173 229 VLLPLLAKEVLGGGAAGYGLL----LAAFGVGALLGALLLGRLSKR----RRRGRLLLIGALLLGLALLVLGLSPSLWLL 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 335 IALLCLGGFAHQTLSVTVITLCSDLFPHDQVATATGVSGTAANLGVLIFTLSLGSMVDQIGYQPFFIVLGLLDLVGAALL 414
Cdd:cd06173 301 LAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLL 380
|
...
gi 695171606 415 WTL 417
Cdd:cd06173 381 LLL 383
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
26-177 |
1.80e-06 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 49.48 E-value: 1.80e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 26 VAMIINYLTRSILGVAAPAIMAEQHiSSAQYSWITGAFQFGIM-FQPLAGYLLDVIGLKVGFTLFVAIWSCITLGHGFAN 104
Cdd:cd17502 3 LALFLAALDQTIVATALPTIVAEFG-GLSLVSWVGTAYLLTSTaFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAP 81
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 695171606 105 GWMGFAGLRGALGLVEGSAQPAGMKLVAEWFPARERGVAGGIyqIGASFG--AVFAPPLVAWAVFNHSWRAAFFV 177
Cdd:cd17502 82 NMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGY--IGAVFGiaSVAGPLIGGAFTDHLSWRWCFYI 154
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
19-199 |
2.02e-06 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 49.58 E-value: 2.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 19 TIIALFVVAmIINYLTRSILGVAAPAIMAEQHISSAQYSWITGAFQFGIMFQP-LAGYLLDVIGLKVGFTLFVAIWSCIT 97
Cdd:PRK11551 16 TIGLCFLVA-LLEGLDLQSAGVAAPRMAQEFGLDVAQMGWAFSAGILGLLPGAlLGGRLADRIGRKRILIVSVALFGLFS 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 98 LGHGFANGWMGFAGLRGALGLVEGSAQPAGMKLVAEWFPARERGVAGGIYQIGASFGAVFAPPLVAWAVFNHSWRAAFFV 177
Cdd:PRK11551 95 LATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYV 174
|
170 180
....*....|....*....|..
gi 695171606 178 aGGLGLAWVVAWLAWYAPPQRH 199
Cdd:PRK11551 175 -GGVGPLLLVPLLMRWLPESRA 195
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
65-415 |
2.52e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 49.52 E-value: 2.52e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 65 FGIMFQPLAGYLLD-------------VIGLKVGFTLFVAIWSCITLGHGFANGWmgFAGLRGALGLVEGSAQPAGMKLV 131
Cdd:COG2211 58 WDAITDPLIGALSDrtrtrwgrrrpwiLIGAIPLALSFVLLFTAPDLSPTGKLIY--ALVTYLLLGLAYTLVNIPYSALG 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 132 AEWFP-ARERGVAGGIYQIGASFG----AVFAPPLVAWAVFN--HSWRAAFFVAGGLGLA--WVVAWLAW--YAPPQRHR 200
Cdd:COG2211 136 AELTPdYEERTRLSSWRFAFAGLGgllaSVLPPPLVAAFGGDaaLGYRLTALIFAVLGLLafLLTFFGTKerPVPEEEKV 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 201 RLSDGertlivagqeaalvkhrrrppLGELLRKRNLWTIAAARFLADPVWGMLSLWMPLYLVQARHFDLGQIALFAWLPF 280
Cdd:COG2211 216 SLKES---------------------LKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYF 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 281 LAADLGCLFGPAVVAFLQRRGVGLIdarrgAFTLGAVLMTGMMFVGTvTSPAAAIALLCLGGFAHQTLSVTVITLCSDLF 360
Cdd:COG2211 275 LAALLGAPLWPRLAKRFGKKKAFII-----GLLLAALGLLLLFFLGP-GNLWLLLVLAALAGIGLGAILVLPWAMLADVV 348
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 695171606 361 PHDQVAT-------ATGVSGTAANLGVLIFTLSLGSMVDQIGYQP---------------FFIVLGLLDLVGAALLW 415
Cdd:COG2211 349 DYDEWKTgrrreglYFGIFTFAIKLGQALAGALAGLLLALFGYVAgaaqspsaltgirllFFLLPAVLLLLAALLLL 425
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
152-415 |
3.23e-06 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 48.70 E-value: 3.23e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 152 SFGAVFAPPLVAWAVFNHSWRAAFFVAGGLGLawVVAWLAWYAPPQRHRRLSDGERTlivagqeaalvkhrrrPPLGELL 231
Cdd:cd17471 135 SLAWVIGPPLAFLLLDVLGFTGLFLLAALLYL--VVALLVLFLLPSVKPPAQKATPA----------------SSLVKAP 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 232 RKRNLWTIAAARFLADPVWGMLSLWMPLYLVQARHFDlgqIALFAWLPFLAADLGCLFGPAVVAFLQRRGVGLIdaRRGA 311
Cdd:cd17471 197 VNRRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGS---ESWVGLLFGLAAALEIPIMLLAGLLAKRFGKRRL--LLAG 271
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 312 FTLGAVLMTGMMFVgtvTSPAAAIALLCLGGFAHQTLSVTVITLCSDLFPhDQVATATGVSGTAANLGVLIFTLSLGSMV 391
Cdd:cd17471 272 FLAGVLFYLGLALA---TSLWQLIALQLLNAIFIGITAGLGISYFQDLMP-GQPGLATTLYSNASRIGSLLGGLLAGVIA 347
|
250 260
....*....|....*....|....
gi 695171606 392 DQIGYQPFFIVLGLLDLVGAALLW 415
Cdd:cd17471 348 QYFGYRAVFLVCAVLALLALVLLL 371
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
23-420 |
3.27e-05 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 45.64 E-value: 3.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 23 LFVVAMI--INYLTRSILGVAAPAIMAEQHISSAQYSWITGAFQFGIMFQPL-AGYLLDVIGLK----VGFTLFVaiwsC 95
Cdd:cd17323 1 VFIISFLtfVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLiWAPLSELYGRRpvylVSLFIFV----I 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 96 ITLGHGFANGWMGFAGLRGALGLVEGSAQPAGMKLVAEWFPARERGVAGGIYQIGASFGAVFAPPLVAWAVFNHSWRAAF 175
Cdd:cd17323 77 FQIGCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 176 FVA---GGLGLAWVVAWLawyaPPqrhrrlsdgertlivagqeaalvkhrrrpplgellrkrnlwtIAAARFLADPVWGM 252
Cdd:cd17323 157 WFLaiiSGFCLILIFLFL----PI------------------------------------------VLLLGLYVGLVYAI 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 253 LSLWM---PLYLVQARHFDLGQIAlfawLPFLAADLGCLFGPAVVAFLQRRGVGLIDARRGAFTLGAVLMTGMMFvgtvT 329
Cdd:cd17323 191 LYLFLtafPYVFGEVYGFSPGEVG----LMYLPIGIGALIGSIIGGRLSDYYYRRLKKKNGGKPEPEARLPPAFI----G 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 330 SPAAAIALLCLG-------------------GFAHQTLSVTVITLCSDLFPHdQVATATGVSGTAANLGVLIFTLSLGSM 390
Cdd:cd17323 263 AFLFPIGLFIFGwtiyphihwivpiigsaffGFGLMLIFQSSLTYLVDSYPK-YAASALAANTLVRSIFAAIFPLFAQPM 341
|
410 420 430
....*....|....*....|....*....|
gi 695171606 391 VDQIGYQPFFIVLGLLDLVGAALLWTLIRK 420
Cdd:cd17323 342 FNNLGVGWAFTLLAFISLAMIPIPFIFYKY 371
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
74-195 |
4.45e-05 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 45.39 E-value: 4.45e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 74 GYLLDVIGLKVGFTLFVAIWSCITLGHGFANGWMGFAGLRGALGLVEGSAQPAGMKLVAEWFPARERGVAGGIYQIGASF 153
Cdd:TIGR00898 148 GYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRAIVGTLIQVFFSL 227
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 695171606 154 GAVFApPLVAWavFNHSWRAAFFVAGGLGLAWVVAWlaWYAP 195
Cdd:TIGR00898 228 GLVLL-PLVAY--FIPDWRWLQLAVSLPTFLFFLLS--WFVP 264
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
239-421 |
6.81e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 44.72 E-value: 6.81e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 239 IAAARFLADPVWGMLSLWMPLYLVQARHFDLGQIALFAWLPFLAAdlgCLFGPAVVAFLQRRGvglidARRGAFTLGAVL 318
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGY---ALAQPLAGRLSDRFG-----RRRVLLIGLLLF 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 319 MTGMMFVGTVTSPAAAIALLCLGGFAHQTLSVTVITLCSDLFPHDQVATATGVSGTAANLGVLIFTLSLGSMVDQIGYQP 398
Cdd:pfam07690 73 ALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRA 152
|
170 180
....*....|....*....|...
gi 695171606 399 FFIVLGLLDLVGAALLWTLIRKA 421
Cdd:pfam07690 153 AFLILAILSLLAAVLLLLPRPPP 175
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
11-419 |
7.12e-05 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 44.70 E-value: 7.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 11 RRFPYIRWTIIALFVVAMIINYLTRSILGVAAPAIMAEQHISS------AQYSWIT-GAFQF--GIM--------FQPLA 73
Cdd:PRK11663 15 ARYRYWRRHILITMYLGYALFYFTRKSFNAAMPEMLADLGLSRsdigllATLFYITyGVSKFvsGIVsdrsnaryFMGIG 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 74 GYLLDVIGLKVGFTLFVAIWSCITLGHGFANGWmgfaglrgalglvegsAQPAGMKLVAEWFPARERGVAGGIYQIGASF 153
Cdd:PRK11663 95 LIATGIINILFGFSSSLWAFALLWVLNAFFQGW----------------GWPVCAKLLTAWYSRTERGGWWAIWNTAHNV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 154 GAVFAPPLVAWAVFNHSWRAAFFVAGGLGLAwVVAWLAWyappqrhrRLSDGERTL--------------IVAGQEAALV 219
Cdd:PRK11663 159 GGALIPLVVGAIALHYGWRYGMMIAGIIAIV-VGLFLCW--------RLRDKPQAMglpsvgewrhdaleLAQQQEGAGL 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 220 KHRrrpplgELLRK-----RNLWTIAAARFLADPVWGMLSLWMPLYLVQARHFDL----GQIALFawlpflaaDLGCLFG 290
Cdd:PRK11663 230 SRK------EILTKyvllnPYIWLLSFSYVLVYVVRAAINDWGNLYMSETLGVDLvtanSAVSMF--------ELGGFIG 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 291 PAVVAFLQRRgvgLIDARRGA----FTLGAVLMTGMMFVGTVTSPAAAIALLCLGG---FAHQTLSVTVITLCSDlfpHD 363
Cdd:PRK11663 296 ALVAGWGSDK---LFNGNRGPmnliFAAGILLSVGSLWLMPFASYVMQAACFFTIGffvFGPQMLIGMAAAECSH---KE 369
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 695171606 364 QVATATGVSGTAANLGVLIFTLSLGSMVDQIGYQPFFIVLGLLDLVGAALLWTLIR 419
Cdd:PRK11663 370 AAGAATGFVGLFAYLGAALSGYPLAKVLEIWHWTGFFVVISIAAGISALLLLPFLN 425
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
57-195 |
8.77e-05 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 44.11 E-value: 8.77e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 57 SWITGAFQFGIMF-QPLAGYLLDVIGLKVGFTLFVAIWSCITLGHGFANGWMGFAGLRGALGLVEGSAQPAGMKLVAEWF 135
Cdd:cd17317 28 ALVQTIFFLGVLIgSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIV 107
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 136 PARERGVAGGIYQIGASFGAVFAPPLvawAVFNHSWRAAFFVAGGLGLawVVAWLAWYAP 195
Cdd:cd17317 108 GPKYRSFVGILFGLFWALGYMLLALL---AYLIRDWRWLQLAISLPGL--LFLLLLWWLP 162
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
232-419 |
1.26e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 43.81 E-value: 1.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 232 RKRNLWTIAAARFLADPVWGMLSLWMPLyLVQARHFDLGQIALFAWLPFLAADLGCLFGPAVVAFLQRRGVglidarrga 311
Cdd:COG2814 8 RWLALLALALGAFLSGLGIGIVLPALPL-IAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRV--------- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 312 FTLGAVLMTGMMFV-GTVTSPAAAIALLCLGGFAHQTLSVTVITLCSDLFPHDQVATATGVSGTAANLGVLIFTLSLGSM 390
Cdd:COG2814 78 LLLGLLLFALGSLLcALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLL 157
|
170 180
....*....|....*....|....*....
gi 695171606 391 VDQIGYQPFFIVLGLLDLVGAALLWTLIR 419
Cdd:COG2814 158 ADLFGWRWVFLVNAVLALLALLLLLRLLP 186
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
10-190 |
1.56e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 43.76 E-value: 1.56e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 10 VRRFPYIRWTIIALFVVAMIINYLTrsilgVAAPAIMAEQ-HISSAQYSWITGAFQFGIMFQPL-AGYLLDVIGLKVGFT 87
Cdd:cd06173 204 LRRSPLLRLLLLALALFALLGGALT-----VLLPLLAKEVlGGGAAGYGLLLAAFGVGALLGALlLGRLSKRRRRGRLLL 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 88 LFVAIWSCITLGHGFANGWMGFAGLRGALGLVEGSAQPAGMKLVAEWFPARERGVAGGIYQIGASFGAVFAPPLVAWAVF 167
Cdd:cd06173 279 IGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLAD 358
|
170 180
....*....|....*....|...
gi 695171606 168 NHSWRAAFFVAGGLGLAWVVAWL 190
Cdd:cd06173 359 ALGLSAVFLLAGALLLLAALLLL 381
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
34-415 |
3.68e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 42.53 E-value: 3.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 34 TRSILgvaaPAIMAEQHISSAQYSWITG-AFQFGIMFQPLAGYLLDVIGLKVGFTLF-VAIWSCITLGHGFANGWMGFAG 111
Cdd:cd17370 18 ARSIL----PLFLVVLGASAAAVGLIEGlAEALGSLLRLFSGYLSDRTGKRKPLVILgYGLSALAKPLLALAGSWQLVLL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 112 LRGALGLVEGSAQPAGMKLVAEWFPARERGVAGGIYQIGASFGAVFAPPLVAW--AVFNHSWRAAFFVAGGLGLAWVVAW 189
Cdd:cd17370 94 LRILERLGKGIRTPPRDALLADATPPSGRGKAFGLHRALDTLGAVLGPLLAALllYLLGGNYRTIFLLAAIPALLALLIL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 190 LAWYAPPQRhrrlsdgertlivagqEAALVKHRRRPPLGELLRKRNLWTIAAARFLAdpvwGMLSLWMPLYLVQARHFDL 269
Cdd:cd17370 174 LFVVKEYPR----------------PPKLRKKSKKTSLKKLPKAFWLYLLAVALFAL----GNFSFAFLILRAQELGLSA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 270 GQIALFaWLPFLAADlgCLFGPAVVAFLQRRGVGLIDArrGAFTLGAVLMTGMMFVGTVTSPAAAIALLCLGGFAHQTLS 349
Cdd:cd17370 234 ALIPLL-YALFNLVY--ALAAYPAGRLSDRIGRKKLLI--LGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIE 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 695171606 350 VTVItlcSDLFPHDQVATATGVSGTAANLGVLIFTLSLGSMVDQIGYQPFFIVLGLLDLVGAALLW 415
Cdd:cd17370 309 RAAV---ADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
17-155 |
5.62e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 41.88 E-value: 5.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 17 RWTIIALFVVAMIINYLTRSILGVAAPAIMAEQHISSAQYSWITGAFQFGIMF-QPLAGYLLDVIGLKVGFTLFVAIWSC 95
Cdd:COG2814 206 RPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLgALLAGRLADRFGRRRLLLIGLLLLAL 285
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 96 ITLGHGFANGWMGFAGLRGALGLVEGSAQPAGMKLVAEWFPARERGVAGGIYQIGASFGA 155
Cdd:COG2814 286 GLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS_MFSD1 |
cd17340 |
Major facilitator superfamily domain-containing protein 1; Human major facilitator superfamily ... |
312-415 |
5.78e-04 |
|
Major facilitator superfamily domain-containing protein 1; Human major facilitator superfamily domain-containing protein 1 (MFSD1) is also called smooth muscle cell-associated protein 4 (SMAP-4). The function of MFSD1 is still unknown. Its expression is affected by altered nutrient intake. During starvation, expression of MFSD1 is downregulated in anterior brain sections in mice while it is upregulated in the brainstem. In mice raised on high-fat diet, MFSD1 is specifically downregulated in brainstem and hypothalamus. MFSD1 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340898 [Multi-domain] Cd Length: 394 Bit Score: 41.87 E-value: 5.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 312 FTLGAVLMTGMMFVGTVTSPAAAIALLclgGFAHQTLSVTVITLCSDLFPHDQVATATGVSGTAANLGVLIFTLSLGSMV 391
Cdd:cd17340 289 IALVITLLGHLLLAFTFVNPLIAMVIM---GIGYSMLACALWPMVPLVVPEHQLGTAYGFMQSIQNLGLAVFPIIAGSIL 365
|
90 100
....*....|....*....|....*..
gi 695171606 392 DQIGY---QPFFIVLGLLDLVGAALLW 415
Cdd:cd17340 366 DKKGYlllEVFFIACLCVSLIALIILY 392
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
130-361 |
6.29e-04 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 41.74 E-value: 6.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 130 LVAEWFPARERGVAGGIYQIGASFGAVFAppLVAWAVFNHS----------WRAAFFVAGGL-GLAWVVawlawyappqr 198
Cdd:cd17369 129 MAVEHAPPKRRGFYGSFPQLGAPVGLLLA--TGVFLLLSALlsdeaflswgWRIPFLLSAVLvAVGLYI----------- 195
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 199 hrRLSDGERTLIVAGQEAalvKHRRRPPLGELLRK--RNLWTIAAARFLADPVWGMLSLWMPLYLVQARHFDLgqiALFA 276
Cdd:cd17369 196 --RLRLEETPVFRRAKEA---GQVVRAPLVEVLRRhwRALLLAIGLRLAENVLFYLFTTFALSYATQTLGVDR---STVL 267
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 277 WLPFLAADLGCLFGPAVVAFLQRRGvglidaRRGAFTLGAVLMTGMMF-----VGTVTSPAAAIALLCLGGFAHQTLSVT 351
Cdd:cd17369 268 LAVLIASVVAAITIPLFGWLSDRVG------RRPVYLAGALLAALFAFpffwlLDTGSTWLIVLAAVVVLGVLHGMMYGP 341
|
250
....*....|
gi 695171606 352 VITLCSDLFP 361
Cdd:cd17369 342 QAAFLAELFP 351
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
27-195 |
7.24e-04 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 41.48 E-value: 7.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 27 AMIINYLTRSILGVAAPAIMAEQHISSAQYSWITGAFQFGI-MFQPLAGYLLDVIGLKVGFTLFVAIWSCITLGHGFANG 105
Cdd:cd17476 6 AQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVgTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPN 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 106 WMGFAGLRGALGLVEGSAQPAGMKLVAEWF-PARERGVAGGIYQ----IGASFGAVFAPPLVAWAvfnhSWRAAFFVAGG 180
Cdd:cd17476 86 FIFFIICRALQGLGPAFLLPNAMALLGRTYpPGPRKNIVFSLFGatapLGFALGGVFGGLFAQLA----WWPWIFWFLAI 161
|
170
....*....|....*
gi 695171606 181 LGLAWVVAWLAWYAP 195
Cdd:cd17476 162 LAAIVAVAAIFWTSP 176
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
17-414 |
8.61e-04 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 41.24 E-value: 8.61e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 17 RWTIIALFVVAMIINYLTRSILGVAAPAIMAEQHISSAQYSWITGAFQFG-IMFQPLAGYLLDVIGLK----VGFTLFVA 91
Cdd:cd17314 1 RWFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGmLLTQPILGFIADSFGPRplmaLAGIMVLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 92 IWSCITLGHGFANGWMGFAGLRGAL-GLVEGSAqpagMKLVAEWFPAReRGVAGGIYQIGASFGAVFAPPLVAWAVFNHS 170
Cdd:cd17314 81 GYTYLSYVFNSFPLSYACFVFIGAGtGILYGSA----VLVTTQYFPDT-KGLALGLPTTGYSLGLVLGSPLLRILWVFYG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 171 WRAAFFVAGglglawVVAWLAWYAPPQRHRRLSDGErtlivagQEAALVKHRRRPPLGELLRKRNLWTIAAARFLADPVW 250
Cdd:cd17314 156 LALVYTILG------ILAAIVLSVVSLLGFKEPPDN-------QARLHVQKKKTQTMGEIFRDKVFWILFIAIFLVLIGG 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 251 GMLSLWMPLYLVQARHFDLGQIALFawlpFLAADLGCLFGPAVVAFLQRRGVGLIDARRGAFTLGAVLMTGMMFVGTVTs 330
Cdd:cd17314 223 FLFIANMASLVRSLQLDAPSFVTKL----MSIYGLFNAFGRLLWGIVADFFGGRLSTLSILLTILGLGLCAFLFLLKMT- 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 331 PAAAIALLCLGGFAHQTLSVTVITLCSDLFPHDQVATATGVSGTAANLGVLIFTLSLGSMVDQI-GYQPFFIVLGLLDLV 409
Cdd:cd17314 298 PVGLVLTGSLLGFSYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTpSYISAVYIYAVIVFL 377
|
....*
gi 695171606 410 GAALL 414
Cdd:cd17314 378 ASAIL 382
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
17-201 |
1.33e-03 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 40.87 E-value: 1.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 17 RWTIIALFVVAMIINYLTRSILGVAAPAIMAEQHISSAQYSWITGAFQFGI--MFQPLaGYLLDVIGLKVGFTLFVAIWS 94
Cdd:PRK14995 4 QWLTLVIIVLVYIPVAIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMagMVLPM-GALGDRIGFKRLLMLGGTLFG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 95 CITLGHGFANGWMGFAGLRGALGLVEGSAQPAGMKLVAEWF-PARERGVAGGIYQIGASFGAVFApPLVAWAVFNH-SWR 172
Cdd:PRK14995 83 LASLAAAFSPTASWLIATRALLAIGAAMIVPATLAGIRATFtEEKQRNMALGVWAAVGSGGAAFG-PLVGGILLEHfYWG 161
|
170 180
....*....|....*....|....*....
gi 695171606 173 AAFFVAGGLGLAwVVAWLAWYAPPQRHRR 201
Cdd:PRK14995 162 SVFLINVPIVLV-VMGLTARYVPRQAGRR 189
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
21-417 |
1.57e-03 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 40.23 E-value: 1.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 21 IALFVVAMIINYLTRSIlGVAAPAIMAEQHISSAQYSWITGAFQFGIMFQ-PLAGYLLDVIGLKVgftlfVAIWSCITLG 99
Cdd:cd17352 6 FASFLVNFFTDGILNSF-GVLFVELLEEFGESTSDIAWIGSLLLGVSLFSgPLSSALVNRFGCRP-----VAIAGGLLAA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 100 HGFAngWMGFA----------GLRGALGLveGSAQPAGMKLVAEWFpARERGVAGGIYQIGASFGAVFAPPLVAWAVFNH 169
Cdd:cd17352 80 LGLL--LSSFAtslwqlyltyGVLGGLGL--GLIYSPAIVIVGQYF-EKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNY 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 170 SWRAAFFVAGGLGLAWVVAWLawyappqrhrrlsdgertlivagqeaalvkhrrrppLGELLRKRNLWTIAAARFLAdpv 249
Cdd:cd17352 155 GWRGALLILGGLCLNLCVCGL------------------------------------LLRLLKDPTFVLLALGVSFA--- 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 250 wgMLSLWMPLYLVQARHFDLGQIALFAWlpFLAADLGCL-----FGPAVVAFLQRRGVglidARRGAFTLGAVLMTgMMF 324
Cdd:cd17352 196 --MLGFFVPFVYLPSYAKSLGIDESDAA--FLLSIIGISdivgrILLGLLADKPRIGR----LYLYIFTLLILGLS-LLA 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 325 VGTVTSPAAAIALLCLGGFAHQTLSVTVITLCSDLFPHDQVATATGVSGTAANLGVLIFTLSLGSMVDQIG-YQPFFIVL 403
Cdd:cd17352 267 FPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGdYDAAFYFC 346
|
410
....*....|....
gi 695171606 404 GLLDLVGAALLWTL 417
Cdd:cd17352 347 GACLLLSGVLLFLL 360
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
37-192 |
1.75e-03 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 40.21 E-value: 1.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 37 ILGVAAPAIMAEQHISSAQYSWITGAFQFGIM-FQPLAGYLLDVIGLKVGFTLFVAIWSCITLGHGFANGWMGFAGLRGA 115
Cdd:cd17372 17 LLSFVGPAVQCEWNLSAWQVALITSVVFAGMMiGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWLIILRCL 96
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 695171606 116 LGLVEGsAQPAGMKLVAEWFPARERGVAGGIYQIGASFGAVFAPPLVAWAVFNHSWRAAFFVAGGLGLAWVVA--WLAW 192
Cdd:cd17372 97 VGLGLG-GGPQLASWYLEFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPRLGWRWLLAFSSVPSSLLLVFyrWTPK 174
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
52-192 |
2.33e-03 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 39.95 E-value: 2.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 52 SSAQYSWITGAFQFGIMF-QPLAGYLLDVIGLKVGF----TLFVAIWSCITLGHGFANGWMGFAGlRGALGLVEGSAQPA 126
Cdd:pfam00083 44 LSVLSGLIVSIFSVGCFIgSLFAGKLGDRFGRKKSLlianVLFVIGAVLQGAAKGKWSVYQLIVG-RVLVGIGVGGASVL 122
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 695171606 127 GMKLVAEWFPARERGVAGGIYQIGASFGAVFApplvAWAVF-------NHSWRAAFFVAGGLGLAWVVAWLAW 192
Cdd:pfam00083 123 APMYISEIAPKKLRGALGSLYQLAITFGILLA----YIFGLglnktsnSDGWRIPLGLQLVPALLLIIGLLFL 191
|
|
| MFS_SVOP |
cd17441 |
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ... |
37-178 |
3.98e-03 |
|
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340999 [Multi-domain] Cd Length: 372 Bit Score: 39.03 E-value: 3.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 695171606 37 ILGVAAPAIMAEQHISSAQYSWITGAFQFGIMFQP-LAGYLLDVIGLKVGFTLFVaIWSCI-TLGHGFANGWMGFAGLRG 114
Cdd:cd17441 17 ILSILAPQLHCEWRLPSWQVALLTSVVFIGMMLSSsLWGNISDQYGRKTGLKISV-LWTLYyGILSAFAPIYSWILVLRG 95
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 695171606 115 ALGLVEGSAqPAGMKLVAEWFPARERGVAGGIYQIGASFGAVFAPPLVAWAVFNHSWRAAFFVA 178
Cdd:cd17441 96 LVGFGIGGV-PQSVTLYAEFLPMKSRAKCILLIEVFWALGTVFEVLLAVFVMPTLGWRWLLILS 158
|
|
| |
