|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
27-397 |
4.32e-67 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 217.51 E-value: 4.32e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 27 RIATMAVFFIAGMMYASWGVHVPTVRDRFHLNAAMLSFALLAVAGGSIGAMAANASWIARVGTRRACLSGGLVMAVCAAL 106
Cdd:cd17393 1 RLAVAAFFFINGILMASWATRIPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 107 ILVVPTYWLLLAVLATFGAGMATLDVAMNAEASAVEKALGKPIMSSLHGMFSVGGMAGAAVGGALLSRGMAPAVHLALAA 186
Cdd:cd17393 81 LGLAPSVPALALALFLFGAANGALDVAMNAQGVAVERAYGRPIMSSLHAMWSLGGLAGALLGAAAIGAGVSPGVHLLAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 187 AVSALVLLAACPSVLPHVP--HAEHPDSATPRANRWRSPALWALGAMALVALIAEGAMYDWATVYMRDVVLASPALASAA 264
Cdd:cd17393 161 VLLLLAALVAIRALLPGTGeaAEDRPDGAGKPGFLLPNRLLLLLGLLALAAALAEGAAADWSALYLRDVLGASAALAALG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 265 YAAFSGGMAAARFAGDAVRARFGAPQLVMASATLACVGMVGALLLPNPVAALIGFTMMGLGLANMMPVLFAAAASVKGIH 344
Cdd:cd17393 241 YAVFSLAMTVGRLFGDRLVDRFGDVAVLRAGALLAALGLLLALLAPSVWVALAGFALMGLGLSVVVPLAFSAAGALPGLA 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 685750783 345 AAEGLAHVAGLAYFGLLLGPVIIGAVTQVSSLPIGLSVVAICSALIALAGPKV 397
Cdd:cd17393 321 AGIAVARVATLGYLGFLVGPPLIGFLADATGLRTAFLVVALLALLVALLARAV 373
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
19-402 |
1.23e-60 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 201.24 E-value: 1.23e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 19 SDTARQRARIATMAVFFIAGMMYASWGVHVPTVRDRFHLNAAMLSFALLAVAGGSIGAMAANASWIARVGTRRACLSGGL 98
Cdd:COG0738 2 SKKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 99 VMAVCAALILVVPTYWLLLAVLATFGAGMATLDVAMNAEASAVEKALGKPIMSSLHGMFSVGGMAGAAVGGALLSRGMAP 178
Cdd:COG0738 82 LMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 179 A--VHLALAAAVSALVLLAACPSVLPHVPHAEHPDSATPRANR--WRSPALWALGAMALVALIAEGAMYDWATVYMRDVV 254
Cdd:COG0738 162 SwhLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKslLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 255 LASPALASAAYAAFSGGMAAARFAGDAVRARFGAPQLVMASATLACVGMVGALLLPNPVAALIGFTMMGLGLANMMPVLF 334
Cdd:COG0738 242 GLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIF 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 685750783 335 AAAASVKGIHAAEGLAHVAGLAYFGLLLGPVIIGAVTQVSSLPIGLSVVAICSALIALAGPKVLRRLK 402
Cdd:COG0738 322 SLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRR 389
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
30-392 |
8.52e-26 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 107.02 E-value: 8.52e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 30 TMAVFFIAGMMYASWGVHVPTVRDRFHLNAAMLSFALLAVAGGSIGAMAANASWIARVGTRRACLSGGLVMAVCAALILV 109
Cdd:cd17333 1 LYISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 110 VPTYWLLLAVLATFGAGMATLDVAMNAEASAVEKALGKPIMSSLHGMFSVGGMAGAAVGGALLSRGMAPAVHLALAAAVS 189
Cdd:cd17333 81 TPSIYLFVVLMFLAGLGAGILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWAYLIIGLIY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 190 ALVLLAACPSVLPHVPHAEHPDSATPRANR-----WRSPALWALGAMALVALIAEGAMYDWATVYMRDVVLASPALASAA 264
Cdd:cd17333 161 LLLAILILLTLFPELPSARNPQQSVGAFSAsasrlLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 265 YAAFSGGMAAARFAGDAVRARFGAPQLVMASATLACVGMVGALLLPNPVAALIGFTMMGLGLANMMPVLFAAAASVKGIH 344
Cdd:cd17333 241 LSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLPYA 320
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 685750783 345 AAEGLAHVAGLAYFGLLLGPVIIGAVTQVSSLPIGLSVVAICSALIAL 392
Cdd:cd17333 321 KGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIFV 368
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
23-346 |
1.51e-09 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 58.83 E-value: 1.51e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 23 RQRARIATMAVFFIAGMMYASWGVHVPTVRDRFHLNAAMLSFALLAVAGGSIGAMAANASWIARVGTRRACLSGGLVMAV 102
Cdd:COG2814 8 RWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFAL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 103 CAALILVVPTYWLLLAVLATFGAGMATLDVAMNAEASAVEKALGKPIMSSLHGMFSVGGMAGAAVGGALLSRGMAPAVHL 182
Cdd:COG2814 88 GSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVF 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 183 ALAAAVSALVLLAACpSVLPHVPHAEHPDSATPRANRWRSPALWALGAMALVALIAEGAMYDWATVYMRDVVLASPALAS 262
Cdd:COG2814 168 LVNAVLALLALLLLL-RLLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAG 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 263 AAYAAFSGGMAAARFAGDAVRARFGAPQLVMASATLACVGMVGALLLPNPVAALIGFTMMGLGLANMMPVLFAAAASVKG 342
Cdd:COG2814 247 LLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAP 326
|
....
gi 685750783 343 IHAA 346
Cdd:COG2814 327 PEAR 330
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
21-402 |
2.33e-09 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 58.74 E-value: 2.33e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 21 TARQRARIATMAVFFIAGMMYASWGVHVPTVRDRFHLNAAMLSFAL-LAVAGGSIGAMAANAsWIARVGTRRACLSGGLV 99
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFaIPVLVGALLRIPLGF-LVDRFGPRRVLLIGLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 100 MAVCAALILVVPTYWLLLAVLATFGAGM-ATLDVAMNAEASAVEKALGKPIMSSLHGMFSVGGMAGAAVGGALLSR-GMA 177
Cdd:COG2223 80 LGIGLLLLALAVSYWLLLLLGLLLGIGGgGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAfGWR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 178 PAVHLALAAAVSALVLLAACPSVLPHVPHAEHPDSATPRANRWRSPALWALGAMALVALIAEGAMYDWATVYMRDVVLAS 257
Cdd:COG2223 160 NAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLS 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 258 PALASAAYAAFSGGMAAARFAGDAVRARFGAPQLVMASATLACVGMVG-ALLLPNPVAALIGFTMMGLGLANMMPVLFAA 336
Cdd:COG2223 240 AATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLlALALGSLWLFLVLFLLLGLALGGGNGAVFAL 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 685750783 337 AASVKGIHAAEGLAHVAGLAY-FGLLLGPVIIGAVTQVS-SLPIGLSVVAICSALIALAGPKVLRRLK 402
Cdd:COG2223 320 VPDIFPTKNAGAVYGLVGAAGgLGGFLGPLLFGALLDATgSYTAAFLVFAVLALVALVLTLLLYRRPR 387
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
23-402 |
1.51e-08 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 56.03 E-value: 1.51e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 23 RQRARIATMAVFFIAGMMYASWGVHVPTVRDRFHLNAAMLSFALLAVAGGSIGAMAANASWIARVGTRRACLSGGLVMAV 102
Cdd:COG2271 8 RWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 103 CAALILVVPTYWLLLAVLATFGAGMATLDVAMNAEASAVEKALGKPIMSSLHGMFSVGGMAGAAVGGALLSRGMAPAVHL 182
Cdd:COG2271 88 ATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAF 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 183 ALAAAVSALVLLaacpsvlphvphaehpdsatpranrwrsPALWALGAMALVALIAEGAMYDWATVYMRDVVLASPALAS 262
Cdd:COG2271 168 LILGLPGLLLAL----------------------------LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAG 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 263 AAYAAFSGGMAAARFAGDAVRARFGAPQ--LVMASATLACVGMVGALLLPNPVAALIGFTMMGLGLANMMPVLFAAAA-S 339
Cdd:COG2271 220 LLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAeL 299
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 685750783 340 VKGIHAAEGLAHVAGLAYFGLLLGPVIIGAVTQVSSLPIGLSVVAICSALIALAGPKVLRRLK 402
Cdd:COG2271 300 FPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETR 362
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
32-394 |
6.41e-07 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 51.04 E-value: 6.41e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 32 AVFFIAGMMYASWGVHVPTVRDRFHLNAAMLSFALLAVAGGSIGAMAANASWIARVGTRRACLSGGLVMAVCAALILVVP 111
Cdd:cd17325 3 LALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFAT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 112 TYWLLLAVLATFGAGMATLDVAMNAEASAVEKALGKPIMSSLHGMFSVGGMAGAAVGGALLS--RGMAPAVHLALAAAVS 189
Cdd:cd17325 83 SYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLAdaLGYRAPFLVCAALALL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 190 ALVLLAACPSVLPHVPHAEHPDSATPRANRW---RSPALWALGAMALVALIAEGAMYDWATVYMRDVVLASPALASAAYA 266
Cdd:cd17325 163 ALVLALLLLPEPRPPPNKRAVSAARLRSGLRlllRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 267 AFSGGMAAARFAGDAVRARFGAPQLVMASATLACVGMVGALLLPNPVAALIGFTMMGLGLANMMPVLFAAAASV---KGI 343
Cdd:cd17325 243 AQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIvppEGR 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 685750783 344 HAAEGLAHVAGlaYFGLLLGPVIIGAVTQVsslpIGLSVVAICSALIALAG 394
Cdd:cd17325 323 GTAMGLFNTAF--SLGMVLGPLLGGFLYDA----FGFATPFLAAAALLLLA 367
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
33-393 |
1.15e-06 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 50.12 E-value: 1.15e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 33 VFFIAGMMYASWGVHVPTVRDRFHLNAAMLSFALLAVAGGSIGAMAANASWIARVGTRRACLSGGLVMAVCAALILVVPT 112
Cdd:cd06174 4 GFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 113 YWLLLAVLATFGAGMATLDVAMNAEASAVEKALGKPIMSSLHGMF-SVGGMAGAAVGGALLSRGMAPAVHLALAAAVSAL 191
Cdd:cd06174 84 FWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFgSVGGILGPLLGGILASSLGFGWRAVFLIAAALAL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 192 VLLAACPSVLPHVPHA--------EHPDSATPRANRWRSPALWALGAMALVALIAEGAMYDWATVYMRDVVLASPALASA 263
Cdd:cd06174 164 LAAILLLLVVPDPPESarakneeaSSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 264 AYAAFSGGMAAARFAGDAVRAR-FGAPQLVMASATLACVGMVGALLLPNPVAALIGFTMMGLGLANMMPVLFAAAA-SVK 341
Cdd:cd06174 244 LLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAeLFP 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 685750783 342 GIHAAEGLAHVAGLAYFGLLLGPVIIGAVT-QVSSLPIGLSVVAICSALIALA 393
Cdd:cd06174 324 PEIRGTAFGLLNTFGFLGGAIGPLLAGFLLaATFGLTGAFLVLAVLLLLAAIL 376
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
12-400 |
1.76e-06 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 49.49 E-value: 1.76e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 12 PAAHRELSDTARQRARIATMAVFFIA---GMMYASWGVHVPTVRDRFHLNAAMLSFaLLAVAGGSIGAMAANASWIA-RV 87
Cdd:COG2807 2 STTSSSARRSRRAGRWLLLLAIVLVAlnlRPAITSVGPLLPEIRADLGLSATQAGL-LTTLPLLAFGLFAPLAPRLArRF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 88 GTRRACLSGGLVMAVCAALILVVPTYWLLLAVLATFGAGMATLDVAMNAEASAvEKALGKPIMSSLHGMFSVGGMAGAAV 167
Cdd:COG2807 81 GLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKR-WFPDRVGLMTGLYTAAMGLGAALAAG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 168 GGALLSRGMAPAVHLALAAAVSALVLLAACPSVLPHVPHAEHPDSATPRANRWRSPALWALGAMALVALIAEGAMYDWAT 247
Cdd:COG2807 160 LTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLP 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 248 VYMRDvVLASPALASAAYAAFSGGMAAARFAGDAVRARFGAPQLVMASATLACVGMVGALLLPNPVAALIGFTMMGLGLA 327
Cdd:COG2807 240 PILRD-AGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQG 318
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 685750783 328 NMMPVLFAAAASVKGI--HAAEGLAHVAGLAYFGLLLGPVIIGAVTQVS-SLPIGLSVVAICSALIALAGPKVLRR 400
Cdd:COG2807 319 GLFPLALTLIGLRARTpaEAAALSGMAQSVGYLLAALGPLLVGALHDATgSWTAALLLLAALAVLMLVAGLLAGRP 394
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
23-157 |
3.16e-05 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 45.64 E-value: 3.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 23 RQRARIATMAVFFIAGMMYASWGVHVPT-VRDRFHLNAAMLSFALLAVAGGSIGAMAANASWIARVGTRRACLSGGLVMA 101
Cdd:cd17325 197 RDRRLLALFLAIFVLAFAFGALEPFLPLyAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSA 276
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 685750783 102 VCAALILVVPTYWLLLAVLATFGAGMATLDVAMNAEASAVEKALGKPIMSSLHGMF 157
Cdd:cd17325 277 VALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTA 332
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
27-136 |
5.51e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 41.81 E-value: 5.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 27 RIATMAVFFIAGMMYASWGVHVPTVRDRFHLNAAMLSFALLAVAGGSIGAMAANASWIARVGTRRACLSGGLVMAVCAAL 106
Cdd:COG2211 231 LLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLL 310
|
90 100 110
....*....|....*....|....*....|..
gi 685750783 107 ILVVP--TYWLLLAVLATFGAGMATLDVAMNA 136
Cdd:COG2211 311 LFFLGpgNLWLLLVLAALAGIGLGAILVLPWA 342
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
23-136 |
5.95e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 41.83 E-value: 5.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 23 RQRARIATMAVFFIAGMMYASWGVHVPTVRDRFHLNAAMLSFALLAVAGGSIGAMAANASWIARVGTRRACLSGGLVMAV 102
Cdd:cd06173 207 SPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGL 286
|
90 100 110
....*....|....*....|....*....|....
gi 685750783 103 CAALILVVPTYWLLLAVLATFGAGMATLDVAMNA 136
Cdd:cd06173 287 ALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNT 320
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
220-393 |
4.69e-03 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 38.68 E-value: 4.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 220 WRSPALWALGAMALVALIAEGAMYDWATVYMRDVVLASPALASAAYAAFSGGMAAARFAGDAVRARFGAPQLVMASATLA 299
Cdd:cd17324 195 LRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLA 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 300 CVGMVGALLLPNPVAALIGFTMMGLGLANMMPVLFAAAASVKGIHAAEGLAHVAGLAYFGLLLGPVIIGAVTQVSSLPig 379
Cdd:cd17324 275 AALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWA-- 352
|
170
....*....|....
gi 685750783 380 lSVVAICSALIALA 393
Cdd:cd17324 353 -GVGWVGAALLLLA 365
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
32-366 |
6.12e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 38.55 E-value: 6.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 32 AVFFIAGMMYASWGVHVPTVRDRFHLNAAMLSFALLAVAGGSIGAMAANASWIARVGTRRACLSGGLVMAVCAALILVVP 111
Cdd:pfam07690 4 AAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 112 TYWLLLAVLATFGAGMATLDVAMNAEASAVEKALGKPIMSSLHGMFSVGGMAGAAVGGALLS-----RGMAPAVHLALAA 186
Cdd:pfam07690 84 SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAslfgwRAAFLILAILSLL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 187 AVSALVLLAACPSVLPHVPHAEHPDSATPRANRWRSPALWALGAMALVALIAEGAMYDWATVYMrDVVLASPALASAAYA 266
Cdd:pfam07690 164 AAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQ-EVLGLSALLAGLLLG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 267 AFSGGMAAARFAGDAVRARFG---APQLVMASATLACVGMVGALLLPNPVAALIGFTMMGLGLANMMPVLFAAAASVKGI 343
Cdd:pfam07690 243 LGGLLGAIGRLLLGRLSDRLGrrrRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPK 322
|
330 340
....*....|....*....|...
gi 685750783 344 HAAeglAHVAGLAYFGLLLGPVI 366
Cdd:pfam07690 323 EER---GTASGLYNTAGSLGGAL 342
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
221-403 |
9.96e-03 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 38.06 E-value: 9.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 221 RSPALWALGAMALVALIAEGAMYDWATVYMRDVVLASPALASAAYAAFSGGMAAARFAGDAVRaRFGAPQLVMASATLAC 300
Cdd:pfam13347 222 RNRAFLILLASFLLAALAMGVLNGLLLYYFRYVLGNGFAASAFPLVFTIGALLGIPLWPPLAK-RIGKKNTYILGALITI 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 301 VGMVGALLLP--NPVAALIGFTMMGLGLANMMPVLFAAAASV------------------------KGIHAAEGLAHVAG 354
Cdd:pfam13347 301 AGFALALLLGpnNTLLFLVLYIIIGFGYGSSFFLPWSMLADVvdygelrtgkrregtffamwsfisKLATGVGLGVSGLL 380
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 685750783 355 LAYFGLLLGPVIIGAVTqVSSLPIGLSVVAICSALIALAgpkVLRRLKI 403
Cdd:pfam13347 381 LSAFGYNAGDSVQSPQA-VTAIRLLYAVLPAVLFLVALL---LLYFYPL 425
|
|
|