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Conserved domains on  [gi|685750783|gb|AIP31953|]
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major Facilitator Superfamily protein [Paraburkholderia xenovorans LB400]

Protein Classification

MFS transporter( domain architecture ID 13024414)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085|GO:0016020
PubMed:  26758938|26098515|26234418
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_MosC_like cd17393
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ...
 27-397 4.32e-67

Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340951 [Multi-domain]  Cd Length: 373  Bit Score: 217.51  E-value: 4.32e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783  27 RIATMAVFFIAGMMYASWGVHVPTVRDRFHLNAAMLSFALLAVAGGSIGAMAANASWIARVGTRRACLSGGLVMAVCAAL 106
Cdd:cd17393    1 RLAVAAFFFINGILMASWATRIPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 107 ILVVPTYWLLLAVLATFGAGMATLDVAMNAEASAVEKALGKPIMSSLHGMFSVGGMAGAAVGGALLSRGMAPAVHLALAA 186
Cdd:cd17393   81 LGLAPSVPALALALFLFGAANGALDVAMNAQGVAVERAYGRPIMSSLHAMWSLGGLAGALLGAAAIGAGVSPGVHLLAAA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 187 AVSALVLLAACPSVLPHVP--HAEHPDSATPRANRWRSPALWALGAMALVALIAEGAMYDWATVYMRDVVLASPALASAA 264
Cdd:cd17393  161 VLLLLAALVAIRALLPGTGeaAEDRPDGAGKPGFLLPNRLLLLLGLLALAAALAEGAAADWSALYLRDVLGASAALAALG 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 265 YAAFSGGMAAARFAGDAVRARFGAPQLVMASATLACVGMVGALLLPNPVAALIGFTMMGLGLANMMPVLFAAAASVKGIH 344
Cdd:cd17393  241 YAVFSLAMTVGRLFGDRLVDRFGDVAVLRAGALLAALGLLLALLAPSVWVALAGFALMGLGLSVVVPLAFSAAGALPGLA 320

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 685750783 345 AAEGLAHVAGLAYFGLLLGPVIIGAVTQVSSLPIGLSVVAICSALIALAGPKV 397
Cdd:cd17393  321 AGIAVARVATLGYLGFLVGPPLIGFLADATGLRTAFLVVALLALLVALLARAV 373
 
Name Accession Description Interval E-value
MFS_MosC_like cd17393
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ...
 27-397 4.32e-67

Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340951 [Multi-domain]  Cd Length: 373  Bit Score: 217.51  E-value: 4.32e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783  27 RIATMAVFFIAGMMYASWGVHVPTVRDRFHLNAAMLSFALLAVAGGSIGAMAANASWIARVGTRRACLSGGLVMAVCAAL 106
Cdd:cd17393    1 RLAVAAFFFINGILMASWATRIPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 107 ILVVPTYWLLLAVLATFGAGMATLDVAMNAEASAVEKALGKPIMSSLHGMFSVGGMAGAAVGGALLSRGMAPAVHLALAA 186
Cdd:cd17393   81 LGLAPSVPALALALFLFGAANGALDVAMNAQGVAVERAYGRPIMSSLHAMWSLGGLAGALLGAAAIGAGVSPGVHLLAAA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 187 AVSALVLLAACPSVLPHVP--HAEHPDSATPRANRWRSPALWALGAMALVALIAEGAMYDWATVYMRDVVLASPALASAA 264
Cdd:cd17393  161 VLLLLAALVAIRALLPGTGeaAEDRPDGAGKPGFLLPNRLLLLLGLLALAAALAEGAAADWSALYLRDVLGASAALAALG 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 265 YAAFSGGMAAARFAGDAVRARFGAPQLVMASATLACVGMVGALLLPNPVAALIGFTMMGLGLANMMPVLFAAAASVKGIH 344
Cdd:cd17393  241 YAVFSLAMTVGRLFGDRLVDRFGDVAVLRAGALLAALGLLLALLAPSVWVALAGFALMGLGLSVVVPLAFSAAGALPGLA 320

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 685750783 345 AAEGLAHVAGLAYFGLLLGPVIIGAVTQVSSLPIGLSVVAICSALIALAGPKV 397
Cdd:cd17393  321 AGIAVARVATLGYLGFLVGPPLIGFLADATGLRTAFLVVALLALLVALLARAV 373
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
19-402 1.23e-60

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 201.24  E-value: 1.23e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783  19 SDTARQRARIATMAVFFIAGMMYASWGVHVPTVRDRFHLNAAMLSFALLAVAGGSIGAMAANASWIARVGTRRACLSGGL 98
Cdd:COG0738    2 SKKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783  99 VMAVCAALILVVPTYWLLLAVLATFGAGMATLDVAMNAEASAVEKALGKPIMSSLHGMFSVGGMAGAAVGGALLSRGMAP 178
Cdd:COG0738   82 LMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 179 A--VHLALAAAVSALVLLAACPSVLPHVPHAEHPDSATPRANR--WRSPALWALGAMALVALIAEGAMYDWATVYMRDVV 254
Cdd:COG0738  162 SwhLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKslLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVL 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 255 LASPALASAAYAAFSGGMAAARFAGDAVRARFGAPQLVMASATLACVGMVGALLLPNPVAALIGFTMMGLGLANMMPVLF 334
Cdd:COG0738  242 GLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIF 321

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 685750783 335 AAAASVKGIHAAEGLAHVAGLAYFGLLLGPVIIGAVTQVSSLPIGLSVVAICSALIALAGPKVLRRLK 402
Cdd:COG0738  322 SLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRR 389
MFS_1 pfam07690
Major Facilitator Superfamily;
32-366 6.12e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 38.55  E-value: 6.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783   32 AVFFIAGMMYASWGVHVPTVRDRFHLNAAMLSFALLAVAGGSIGAMAANASWIARVGTRRACLSGGLVMAVCAALILVVP 111
Cdd:pfam07690   4 AAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783  112 TYWLLLAVLATFGAGMATLDVAMNAEASAVEKALGKPIMSSLHGMFSVGGMAGAAVGGALLS-----RGMAPAVHLALAA 186
Cdd:pfam07690  84 SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAslfgwRAAFLILAILSLL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783  187 AVSALVLLAACPSVLPHVPHAEHPDSATPRANRWRSPALWALGAMALVALIAEGAMYDWATVYMrDVVLASPALASAAYA 266
Cdd:pfam07690 164 AAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQ-EVLGLSALLAGLLLG 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783  267 AFSGGMAAARFAGDAVRARFG---APQLVMASATLACVGMVGALLLPNPVAALIGFTMMGLGLANMMPVLFAAAASVKGI 343
Cdd:pfam07690 243 LGGLLGAIGRLLLGRLSDRLGrrrRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPK 322

                         330       340
                  ....*....|....*....|...
gi 685750783  344 HAAeglAHVAGLAYFGLLLGPVI 366
Cdd:pfam07690 323 EER---GTASGLYNTAGSLGGAL 342
 
Name Accession Description Interval E-value
MFS_MosC_like cd17393
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ...
 27-397 4.32e-67

Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340951 [Multi-domain]  Cd Length: 373  Bit Score: 217.51  E-value: 4.32e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783  27 RIATMAVFFIAGMMYASWGVHVPTVRDRFHLNAAMLSFALLAVAGGSIGAMAANASWIARVGTRRACLSGGLVMAVCAAL 106
Cdd:cd17393    1 RLAVAAFFFINGILMASWATRIPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 107 ILVVPTYWLLLAVLATFGAGMATLDVAMNAEASAVEKALGKPIMSSLHGMFSVGGMAGAAVGGALLSRGMAPAVHLALAA 186
Cdd:cd17393   81 LGLAPSVPALALALFLFGAANGALDVAMNAQGVAVERAYGRPIMSSLHAMWSLGGLAGALLGAAAIGAGVSPGVHLLAAA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 187 AVSALVLLAACPSVLPHVP--HAEHPDSATPRANRWRSPALWALGAMALVALIAEGAMYDWATVYMRDVVLASPALASAA 264
Cdd:cd17393  161 VLLLLAALVAIRALLPGTGeaAEDRPDGAGKPGFLLPNRLLLLLGLLALAAALAEGAAADWSALYLRDVLGASAALAALG 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 265 YAAFSGGMAAARFAGDAVRARFGAPQLVMASATLACVGMVGALLLPNPVAALIGFTMMGLGLANMMPVLFAAAASVKGIH 344
Cdd:cd17393  241 YAVFSLAMTVGRLFGDRLVDRFGDVAVLRAGALLAALGLLLALLAPSVWVALAGFALMGLGLSVVVPLAFSAAGALPGLA 320

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 685750783 345 AAEGLAHVAGLAYFGLLLGPVIIGAVTQVSSLPIGLSVVAICSALIALAGPKV 397
Cdd:cd17393  321 AGIAVARVATLGYLGFLVGPPLIGFLADATGLRTAFLVVALLALLVALLARAV 373
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
19-402 1.23e-60

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 201.24  E-value: 1.23e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783  19 SDTARQRARIATMAVFFIAGMMYASWGVHVPTVRDRFHLNAAMLSFALLAVAGGSIGAMAANASWIARVGTRRACLSGGL 98
Cdd:COG0738    2 SKKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783  99 VMAVCAALILVVPTYWLLLAVLATFGAGMATLDVAMNAEASAVEKALGKPIMSSLHGMFSVGGMAGAAVGGALLSRGMAP 178
Cdd:COG0738   82 LMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 179 A--VHLALAAAVSALVLLAACPSVLPHVPHAEHPDSATPRANR--WRSPALWALGAMALVALIAEGAMYDWATVYMRDVV 254
Cdd:COG0738  162 SwhLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKslLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVL 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 255 LASPALASAAYAAFSGGMAAARFAGDAVRARFGAPQLVMASATLACVGMVGALLLPNPVAALIGFTMMGLGLANMMPVLF 334
Cdd:COG0738  242 GLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIF 321

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 685750783 335 AAAASVKGIHAAEGLAHVAGLAYFGLLLGPVIIGAVTQVSSLPIGLSVVAICSALIALAGPKVLRRLK 402
Cdd:COG0738  322 SLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRR 389
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 30-392 8.52e-26

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 107.02  E-value: 8.52e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783  30 TMAVFFIAGMMYASWGVHVPTVRDRFHLNAAMLSFALLAVAGGSIGAMAANASWIARVGTRRACLSGGLVMAVCAALILV 109
Cdd:cd17333    1 LYISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 110 VPTYWLLLAVLATFGAGMATLDVAMNAEASAVEKALGKPIMSSLHGMFSVGGMAGAAVGGALLSRGMAPAVHLALAAAVS 189
Cdd:cd17333   81 TPSIYLFVVLMFLAGLGAGILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWAYLIIGLIY 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 190 ALVLLAACPSVLPHVPHAEHPDSATPRANR-----WRSPALWALGAMALVALIAEGAMYDWATVYMRDVVLASPALASAA 264
Cdd:cd17333  161 LLLAILILLTLFPELPSARNPQQSVGAFSAsasrlLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 265 YAAFSGGMAAARFAGDAVRARFGAPQLVMASATLACVGMVGALLLPNPVAALIGFTMMGLGLANMMPVLFAAAASVKGIH 344
Cdd:cd17333  241 LSGFWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLPYA 320

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 685750783 345 AAEGLAHVAGLAYFGLLLGPVIIGAVTQVSSLPIGLSVVAICSALIAL 392
Cdd:cd17333  321 KGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIFV 368
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
23-346 1.51e-09

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 58.83  E-value: 1.51e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783  23 RQRARIATMAVFFIAGMMYASWGVHVPTVRDRFHLNAAMLSFALLAVAGGSIGAMAANASWIARVGTRRACLSGGLVMAV 102
Cdd:COG2814    8 RWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFAL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 103 CAALILVVPTYWLLLAVLATFGAGMATLDVAMNAEASAVEKALGKPIMSSLHGMFSVGGMAGAAVGGALLSRGMAPAVHL 182
Cdd:COG2814   88 GSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVF 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 183 ALAAAVSALVLLAACpSVLPHVPHAEHPDSATPRANRWRSPALWALGAMALVALIAEGAMYDWATVYMRDVVLASPALAS 262
Cdd:COG2814  168 LVNAVLALLALLLLL-RLLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAG 246

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 263 AAYAAFSGGMAAARFAGDAVRARFGAPQLVMASATLACVGMVGALLLPNPVAALIGFTMMGLGLANMMPVLFAAAASVKG 342
Cdd:COG2814  247 LLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAP 326


                 ....
gi 685750783 343 IHAA 346
Cdd:COG2814  327 PEAR 330
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
21-402 2.33e-09

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 58.74  E-value: 2.33e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783  21 TARQRARIATMAVFFIAGMMYASWGVHVPTVRDRFHLNAAMLSFAL-LAVAGGSIGAMAANAsWIARVGTRRACLSGGLV 99
Cdd:COG2223    1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFaIPVLVGALLRIPLGF-LVDRFGPRRVLLIGLLL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 100 MAVCAALILVVPTYWLLLAVLATFGAGM-ATLDVAMNAEASAVEKALGKPIMSSLHGMFSVGGMAGAAVGGALLSR-GMA 177
Cdd:COG2223   80 LGIGLLLLALAVSYWLLLLLGLLLGIGGgGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAfGWR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 178 PAVHLALAAAVSALVLLAACPSVLPHVPHAEHPDSATPRANRWRSPALWALGAMALVALIAEGAMYDWATVYMRDVVLAS 257
Cdd:COG2223  160 NAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLS 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 258 PALASAAYAAFSGGMAAARFAGDAVRARFGAPQLVMASATLACVGMVG-ALLLPNPVAALIGFTMMGLGLANMMPVLFAA 336
Cdd:COG2223  240 AATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLlALALGSLWLFLVLFLLLGLALGGGNGAVFAL 319

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 685750783 337 AASVKGIHAAEGLAHVAGLAY-FGLLLGPVIIGAVTQVS-SLPIGLSVVAICSALIALAGPKVLRRLK 402
Cdd:COG2223  320 VPDIFPTKNAGAVYGLVGAAGgLGGFLGPLLFGALLDATgSYTAAFLVFAVLALVALVLTLLLYRRPR 387
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
23-402 1.51e-08

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 56.03  E-value: 1.51e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783  23 RQRARIATMAVFFIAGMMYASWGVHVPTVRDRFHLNAAMLSFALLAVAGGSIGAMAANASWIARVGTRRACLSGGLVMAV 102
Cdd:COG2271    8 RWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 103 CAALILVVPTYWLLLAVLATFGAGMATLDVAMNAEASAVEKALGKPIMSSLHGMFSVGGMAGAAVGGALLSRGMAPAVHL 182
Cdd:COG2271   88 ATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAF 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 183 ALAAAVSALVLLaacpsvlphvphaehpdsatpranrwrsPALWALGAMALVALIAEGAMYDWATVYMRDVVLASPALAS 262
Cdd:COG2271  168 LILGLPGLLLAL----------------------------LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAG 219

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 263 AAYAAFSGGMAAARFAGDAVRARFGAPQ--LVMASATLACVGMVGALLLPNPVAALIGFTMMGLGLANMMPVLFAAAA-S 339
Cdd:COG2271  220 LLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAeL 299

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 685750783 340 VKGIHAAEGLAHVAGLAYFGLLLGPVIIGAVTQVSSLPIGLSVVAICSALIALAGPKVLRRLK 402
Cdd:COG2271  300 FPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETR 362
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 32-394 6.41e-07

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 51.04  E-value: 6.41e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783  32 AVFFIAGMMYASWGVHVPTVRDRFHLNAAMLSFALLAVAGGSIGAMAANASWIARVGTRRACLSGGLVMAVCAALILVVP 111
Cdd:cd17325    3 LALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFAT 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 112 TYWLLLAVLATFGAGMATLDVAMNAEASAVEKALGKPIMSSLHGMFSVGGMAGAAVGGALLS--RGMAPAVHLALAAAVS 189
Cdd:cd17325   83 SYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLAdaLGYRAPFLVCAALALL 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 190 ALVLLAACPSVLPHVPHAEHPDSATPRANRW---RSPALWALGAMALVALIAEGAMYDWATVYMRDVVLASPALASAAYA 266
Cdd:cd17325  163 ALVLALLLLPEPRPPPNKRAVSAARLRSGLRlllRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFG 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 267 AFSGGMAAARFAGDAVRARFGAPQLVMASATLACVGMVGALLLPNPVAALIGFTMMGLGLANMMPVLFAAAASV---KGI 343
Cdd:cd17325  243 AQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIvppEGR 322

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
gi 685750783 344 HAAEGLAHVAGlaYFGLLLGPVIIGAVTQVsslpIGLSVVAICSALIALAG 394
Cdd:cd17325  323 GTAMGLFNTAF--SLGMVLGPLLGGFLYDA----FGFATPFLAAAALLLLA 367
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 33-393 1.15e-06

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 50.12  E-value: 1.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783  33 VFFIAGMMYASWGVHVPTVRDRFHLNAAMLSFALLAVAGGSIGAMAANASWIARVGTRRACLSGGLVMAVCAALILVVPT 112
Cdd:cd06174    4 GFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 113 YWLLLAVLATFGAGMATLDVAMNAEASAVEKALGKPIMSSLHGMF-SVGGMAGAAVGGALLSRGMAPAVHLALAAAVSAL 191
Cdd:cd06174   84 FWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFgSVGGILGPLLGGILASSLGFGWRAVFLIAAALAL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 192 VLLAACPSVLPHVPHA--------EHPDSATPRANRWRSPALWALGAMALVALIAEGAMYDWATVYMRDVVLASPALASA 263
Cdd:cd06174  164 LAAILLLLVVPDPPESarakneeaSSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGL 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 264 AYAAFSGGMAAARFAGDAVRAR-FGAPQLVMASATLACVGMVGALLLPNPVAALIGFTMMGLGLANMMPVLFAAAA-SVK 341
Cdd:cd06174  244 LLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAeLFP 323

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 685750783 342 GIHAAEGLAHVAGLAYFGLLLGPVIIGAVT-QVSSLPIGLSVVAICSALIALA 393
Cdd:cd06174  324 PEIRGTAFGLLNTFGFLGGAIGPLLAGFLLaATFGLTGAFLVLAVLLLLAAIL 376
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
12-400 1.76e-06

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 49.49  E-value: 1.76e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783  12 PAAHRELSDTARQRARIATMAVFFIA---GMMYASWGVHVPTVRDRFHLNAAMLSFaLLAVAGGSIGAMAANASWIA-RV 87
Cdd:COG2807    2 STTSSSARRSRRAGRWLLLLAIVLVAlnlRPAITSVGPLLPEIRADLGLSATQAGL-LTTLPLLAFGLFAPLAPRLArRF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783  88 GTRRACLSGGLVMAVCAALILVVPTYWLLLAVLATFGAGMATLDVAMNAEASAvEKALGKPIMSSLHGMFSVGGMAGAAV 167
Cdd:COG2807   81 GLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKR-WFPDRVGLMTGLYTAAMGLGAALAAG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 168 GGALLSRGMAPAVHLALAAAVSALVLLAACPSVLPHVPHAEHPDSATPRANRWRSPALWALGAMALVALIAEGAMYDWAT 247
Cdd:COG2807  160 LTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLP 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 248 VYMRDvVLASPALASAAYAAFSGGMAAARFAGDAVRARFGAPQLVMASATLACVGMVGALLLPNPVAALIGFTMMGLGLA 327
Cdd:COG2807  240 PILRD-AGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQG 318

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 685750783 328 NMMPVLFAAAASVKGI--HAAEGLAHVAGLAYFGLLLGPVIIGAVTQVS-SLPIGLSVVAICSALIALAGPKVLRR 400
Cdd:COG2807  319 GLFPLALTLIGLRARTpaEAAALSGMAQSVGYLLAALGPLLVGALHDATgSWTAALLLLAALAVLMLVAGLLAGRP 394
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 23-157 3.16e-05

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 45.64  E-value: 3.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783  23 RQRARIATMAVFFIAGMMYASWGVHVPT-VRDRFHLNAAMLSFALLAVAGGSIGAMAANASWIARVGTRRACLSGGLVMA 101
Cdd:cd17325  197 RDRRLLALFLAIFVLAFAFGALEPFLPLyAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSA 276

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 685750783 102 VCAALILVVPTYWLLLAVLATFGAGMATLDVAMNAEASAVEKALGKPIMSSLHGMF 157
Cdd:cd17325  277 VALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTA 332
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
27-136 5.51e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 41.81  E-value: 5.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783  27 RIATMAVFFIAGMMYASWGVHVPTVRDRFHLNAAMLSFALLAVAGGSIGAMAANASWIARVGTRRACLSGGLVMAVCAAL 106
Cdd:COG2211  231 LLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLL 310

                         90       100       110
                 ....*....|....*....|....*....|..
gi 685750783 107 ILVVP--TYWLLLAVLATFGAGMATLDVAMNA 136
Cdd:COG2211  311 LFFLGpgNLWLLLVLAALAGIGLGAILVLPWA 342
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 23-136 5.95e-04

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 41.83  E-value: 5.95e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783  23 RQRARIATMAVFFIAGMMYASWGVHVPTVRDRFHLNAAMLSFALLAVAGGSIGAMAANASWIARVGTRRACLSGGLVMAV 102
Cdd:cd06173  207 SPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGL 286

                         90       100       110
                 ....*....|....*....|....*....|....
gi 685750783 103 CAALILVVPTYWLLLAVLATFGAGMATLDVAMNA 136
Cdd:cd06173  287 ALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNT 320
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 220-393 4.69e-03

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 38.68  E-value: 4.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 220 WRSPALWALGAMALVALIAEGAMYDWATVYMRDVVLASPALASAAYAAFSGGMAAARFAGDAVRARFGAPQLVMASATLA 299
Cdd:cd17324  195 LRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLA 274

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783 300 CVGMVGALLLPNPVAALIGFTMMGLGLANMMPVLFAAAASVKGIHAAEGLAHVAGLAYFGLLLGPVIIGAVTQVSSLPig 379
Cdd:cd17324  275 AALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWA-- 352

                        170
                 ....*....|....
gi 685750783 380 lSVVAICSALIALA 393
Cdd:cd17324  353 -GVGWVGAALLLLA 365
MFS_1 pfam07690
Major Facilitator Superfamily;
32-366 6.12e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 38.55  E-value: 6.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783   32 AVFFIAGMMYASWGVHVPTVRDRFHLNAAMLSFALLAVAGGSIGAMAANASWIARVGTRRACLSGGLVMAVCAALILVVP 111
Cdd:pfam07690   4 AAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783  112 TYWLLLAVLATFGAGMATLDVAMNAEASAVEKALGKPIMSSLHGMFSVGGMAGAAVGGALLS-----RGMAPAVHLALAA 186
Cdd:pfam07690  84 SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAslfgwRAAFLILAILSLL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783  187 AVSALVLLAACPSVLPHVPHAEHPDSATPRANRWRSPALWALGAMALVALIAEGAMYDWATVYMrDVVLASPALASAAYA 266
Cdd:pfam07690 164 AAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQ-EVLGLSALLAGLLLG 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783  267 AFSGGMAAARFAGDAVRARFG---APQLVMASATLACVGMVGALLLPNPVAALIGFTMMGLGLANMMPVLFAAAASVKGI 343
Cdd:pfam07690 243 LGGLLGAIGRLLLGRLSDRLGrrrRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPK 322

                         330       340
                  ....*....|....*....|...
gi 685750783  344 HAAeglAHVAGLAYFGLLLGPVI 366
Cdd:pfam07690 323 EER---GTASGLYNTAGSLGGAL 342
MFS_2 pfam13347
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ...
 221-403 9.96e-03

MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.


Pssm-ID: 433134 [Multi-domain]  Cd Length: 427  Bit Score: 38.06  E-value: 9.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783  221 RSPALWALGAMALVALIAEGAMYDWATVYMRDVVLASPALASAAYAAFSGGMAAARFAGDAVRaRFGAPQLVMASATLAC 300
Cdd:pfam13347 222 RNRAFLILLASFLLAALAMGVLNGLLLYYFRYVLGNGFAASAFPLVFTIGALLGIPLWPPLAK-RIGKKNTYILGALITI 300

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685750783  301 VGMVGALLLP--NPVAALIGFTMMGLGLANMMPVLFAAAASV------------------------KGIHAAEGLAHVAG 354
Cdd:pfam13347 301 AGFALALLLGpnNTLLFLVLYIIIGFGYGSSFFLPWSMLADVvdygelrtgkrregtffamwsfisKLATGVGLGVSGLL 380

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 685750783  355 LAYFGLLLGPVIIGAVTqVSSLPIGLSVVAICSALIALAgpkVLRRLKI 403
Cdd:pfam13347 381 LSAFGYNAGDSVQSPQA-VTAIRLLYAVLPAVLFLVALL---LLYFYPL 425
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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