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Conserved domains on  [gi|685665882|gb|AIO53008|]
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magnesium and cobalt transport protein CorA [Burkholderia mallei]

Protein Classification

magnesium and cobalt transport protein CorA( domain architecture ID 10191301)

magnesium and cobalt transport protein CorA mediates both influx and efflux of magnesium, and may also transport nickel and cobalt

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MtCorA-like cd12830
Mycobacterium tuberculosis CorA-like subfamily; This bacterial subfamily belongs to the ...
 31-325 1.50e-142

Mycobacterium tuberculosis CorA-like subfamily; This bacterial subfamily belongs to the Thermotoga maritima CorA (TmCorA)-like family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subfamily includes the Mg2+ transporter Mycobacterium tuberculosis CorA (which also transports Co2+). Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by a related protein, Saccharomyces cerevisiae Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


:

Pssm-ID: 213364 [Multi-domain]  Cd Length: 292  Bit Score: 404.21  E-value: 1.50e-142
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882  31 CFVWVALKDPEPDEIERMGEEFGLHELALEDARKGHQRPKIEEYGDALFAVLHTVE-IDGQGELQVGELNVFVGPNYVLS 109
Cdd:cd12830    1 GFVWVGLHEPDAEELAAVAEEFGLHELAVEDAVHAHQRPKLERYGDSLFLVLRTARyVDHTEEVETGETHVFVGPDFVVT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882 110 IRSHTEQDFRAVRARCEREPHLLKEGAAFVFYALMDQVVDRYFPTLEALGAELEALEDRIFEKTGtaaaRALIEDLYRLK 189
Cdd:cd12830   81 VRHGAAGPLARVRARLEADPELLALGPDAVLYAILDFIVDGYLPVAEELEDDVDELEEEVFSPDR----RDDIERIYRLK 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882 190 RRLVMLQQHTAPLVEPLAKLVGGRVPQVCAGMDHYFRDVYDHLLRIVRTIEGRREMLVTAIQVNLGMISLAENEVTKRLG 269
Cdd:cd12830  157 REVLEFRRAVDPLVEVLRRLARGHEPLIPKELRPYFRDVADHLLRVADRVDSLRELLSSALQANLALVSVQQNEDMRKIS 236

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 685665882 270 SFAALFAIPTMIAGIYGMNFNNIPELHWRFCFYVCLGVMAAADLFLWRRFRKAGWL 325
Cdd:cd12830  237 AWAAILAVPTAIAGIYGMNFDHMPELHWTYGYPLVLGLMVAVCLGLYRRFRRNGWL 292
 
Name Accession Description Interval E-value
MtCorA-like cd12830
Mycobacterium tuberculosis CorA-like subfamily; This bacterial subfamily belongs to the ...
 31-325 1.50e-142

Mycobacterium tuberculosis CorA-like subfamily; This bacterial subfamily belongs to the Thermotoga maritima CorA (TmCorA)-like family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subfamily includes the Mg2+ transporter Mycobacterium tuberculosis CorA (which also transports Co2+). Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by a related protein, Saccharomyces cerevisiae Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213364 [Multi-domain]  Cd Length: 292  Bit Score: 404.21  E-value: 1.50e-142
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882  31 CFVWVALKDPEPDEIERMGEEFGLHELALEDARKGHQRPKIEEYGDALFAVLHTVE-IDGQGELQVGELNVFVGPNYVLS 109
Cdd:cd12830    1 GFVWVGLHEPDAEELAAVAEEFGLHELAVEDAVHAHQRPKLERYGDSLFLVLRTARyVDHTEEVETGETHVFVGPDFVVT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882 110 IRSHTEQDFRAVRARCEREPHLLKEGAAFVFYALMDQVVDRYFPTLEALGAELEALEDRIFEKTGtaaaRALIEDLYRLK 189
Cdd:cd12830   81 VRHGAAGPLARVRARLEADPELLALGPDAVLYAILDFIVDGYLPVAEELEDDVDELEEEVFSPDR----RDDIERIYRLK 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882 190 RRLVMLQQHTAPLVEPLAKLVGGRVPQVCAGMDHYFRDVYDHLLRIVRTIEGRREMLVTAIQVNLGMISLAENEVTKRLG 269
Cdd:cd12830  157 REVLEFRRAVDPLVEVLRRLARGHEPLIPKELRPYFRDVADHLLRVADRVDSLRELLSSALQANLALVSVQQNEDMRKIS 236

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 685665882 270 SFAALFAIPTMIAGIYGMNFNNIPELHWRFCFYVCLGVMAAADLFLWRRFRKAGWL 325
Cdd:cd12830  237 AWAAILAVPTAIAGIYGMNFDHMPELHWTYGYPLVLGLMVAVCLGLYRRFRRNGWL 292
CorA COG0598
Mg2+ and Co2+ transporter CorA [Inorganic ion transport and metabolism];
26-325 2.57e-114

Mg2+ and Co2+ transporter CorA [Inorganic ion transport and metabolism];


Pssm-ID: 440363 [Multi-domain]  Cd Length: 305  Bit Score: 332.95  E-value: 2.57e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882  26 VAKPECFVWVALKDPEPDEIERMGEEFGLHELALEDARKGHQRPKIEEYGDALFAVLHTVEID-GQGELQVGELNVFVGP 104
Cdd:COG0598    9 LLDPEGFVWIDLDGPTDEELEWLAEEFGLHPLALEDALDIEQRPKLEEYDDYLFIVLRTLNYNeEEEELETGPLSIFLGP 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882 105 NYVLSIRSHTEQDFRAVRARCEREPHLLKEGAAFVFYALMDQVVDRYFPTLEALGAELEALEDRIFEKTGtaaaRALIED 184
Cdd:COG0598   89 NFLITVRERPLDAFDDVRERLERGPGLLPRGPDYLLYALLDAIVDRYFPVLEELEDELDELEDELFESPD----NELLRR 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882 185 LYRLKRRLVMLQQHTAPLVEPLAKLVGGRVPQVCAGMDHYFRDVYDHLLRIVRTIEGRREMLVTAIQVNLGMISLAENEV 264
Cdd:COG0598  165 LYRLRRELVRLRRALAPLREVLSRLLRGESPLISEEDREYLRDVYDHLERLLEMVDSLRERLSGLLDAYLSLISNRQNEI 244

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 685665882 265 TKRLGSFAALFAIPTMIAGIYGMNFNNIPELHWRFCFYVCLGVMAAADLFLWRRFRKAGWL 325
Cdd:COG0598  245 MKVLTIIAAIFLPPTFIAGIYGMNFEGMPELDWPYGYPIVLGLMLLIAVLLYLYFKRKGWL 305
corA TIGR00383
magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); The article in Microb Comp ...
 33-325 9.86e-66

magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); The article in Microb Comp Genomics 1998;3(3):151-69 discusses this family and suggests that some members may have functions other than Mg2+ transport. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273048 [Multi-domain]  Cd Length: 318  Bit Score: 209.55  E-value: 9.86e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882   33 VWVALKDPEPDE-IERMGEEFGLHELALEDARKGHQRPKIEEYGDALFAVLHTVEIDGQGELQVGELNVFVGPNYVLSIR 111
Cdd:TIGR00383  28 LWIDLIEPTDEErLAKLGQFFAIHPLALEDILNSPQRPKVEEDEDHLFIISFFLNEDEDDTFETEQVSFILGKNLLFTIH 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882  112 SHTEQDFRAVRARCEREPHLLKEGAAFVFYALMDQVVDRYFPTLEALGAELEALEDRIFEKTgtaaARALIEDLYRLKRR 191
Cdd:TIGR00383 108 ERELPAFDSIRERIRTSQKVFEKGADYLLYDIFDAIIDSYFPLLENIEDELEELEDEIISGP----TSTLMDEILSLRTE 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882  192 LVMLQQHTAPLVEPLAKLV-GGRVPQVCAGMDHYFRDVYDHLLRIVRTIEGRREMLVTAIQVNLGMISLAENEVTKRLGS 270
Cdd:TIGR00383 184 LLALRRSLWPLRDVLNFLLrKTHLPIQTEEVREYLRDIYDHILSLLEMIETYRELLSSLMDLYLSLVNNKMNEIMKILTV 263

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 685665882  271 FAALFAIPTMIAGIYGMNFNNIPELHWRFCFYVCLGVMAAADLFLWRRFRKAGWL 325
Cdd:TIGR00383 264 VSTIFIPLTFIAGIYGMNFKFMPELNWKYGYPAVLIVMAVIALGPLIYFRRKGWL 318
CorA pfam01544
CorA-like Mg2+ transporter protein; The CorA transport system is the primary Mg2+ influx ...
 32-321 1.79e-58

CorA-like Mg2+ transporter protein; The CorA transport system is the primary Mg2+ influx system of Salmonella typhimurium and Escherichia coli. CorA is virtually ubiquitous in the Bacteria and Archaea. There are also eukaryotic relatives of this protein. The family includes the MRS2 protein from yeast that is thought to be an RNA splicing protein. However its membership of this family suggests that its effect on splicing is due to altered magnesium levels in the cell.


Pssm-ID: 460246 [Multi-domain]  Cd Length: 292  Bit Score: 189.83  E-value: 1.79e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882   32 FVWVALKDPEPDEIERMGEEFGLHELALEDARKGHQRPKIEEYGDALFAVLHTVEIDGQGELQV-GELNVFVGPNYVLSI 110
Cdd:pfam01544   4 FVWLDLDSPTEAELEWLARTLGLDPLALEDLLDPEERPRVEDYDDYFLLVLPGVNLDDSEEADElVTVSILLGDNFLITV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882  111 RSHTEQDFRAVRARCEREPHLLKeGAAFVFYALMDQVVDRYFPTLEALGAELEALEDRIFEKTgtaaARALIEDLYRLKR 190
Cdd:pfam01544  84 RHEPLPALDEVRKRLTLLGGGPL-DPGDLLYRLLDEIVDRFLELLEKLEDELDELEDELEDET----NNELLRELAALRR 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882  191 RLVMLQQHTAPLVEPLAKLVG-GRVPQVCAGMDHYFRDVYDHLLRIVRTIEGRREMLVTAIQVNLGMISLAENEVTKRLG 269
Cdd:pfam01544 159 SLVYLRRSLLPQRDVLNRLLRrEDDPLLDDEQKEYLRDLLDRLERLLEDLDALRERLRSLQDEYSSLLSERTNRVMKVLT 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 685665882  270 SFAALFAIPTMIAGIYGMNFNNIPELHWRFCFYVC--LGVMAAADLFLWRRFRK 321
Cdd:pfam01544 239 VVTAIFLPLTLITGIYGMNFGGLPELEWSYGYPFVliLGLMILLAILLLFYFRR 292
PRK11085 PRK11085
magnesium/cobalt transporter CorA;
33-325 3.31e-11

magnesium/cobalt transporter CorA;


Pssm-ID: 182951  Cd Length: 316  Bit Score: 63.20  E-value: 3.31e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882  33 VWVALKDPEPDEIERMGEEFG---LHELALEDArKGHQRPKIEEYGDALFAVLHTVEIDGQGELQVGELNVFVGPNYVLs 109
Cdd:PRK11085  27 VWIDLVEPDDDERLRVQSELGqslATRPELEDI-EASARFFEDEDGLHIHSFFFFEDAEDHAGNSTVAFTIRDGRLFTL- 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882 110 iRSHTEQDFRAVRARCEREphLLKEGAAF-----VFYALMDQVVDryfpTLEALGAELEALEDRIFE-KTGTAAARAL-- 181
Cdd:PRK11085 105 -RERELPAFRLYRMRARSQ--TLVDGNAYellldLFETKIEQLAD----EIENIYSDLEKLSRVIMEgHQGDEYDEALst 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882 182 ---IEDLYRLKRRLVMLQQHTAPLVEPLAKLVGGRVPQVcagmdhyfRDVydhlLRIVRTIEGRREMLVTAI----QVNL 254
Cdd:PRK11085 178 laeLEDIGWKVRLCLMDTQRALNFLVRKARLPGGQLEQA--------REI----LRDIESLLPHNESLFQKVnflmQAAM 245

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 685665882 255 GMISLAENEVTKRLGSFAALFAIPTMIAGIYGMNFNNIPELHWRFCFYVCLGVMAAADLFLWRRFRKAGWL 325
Cdd:PRK11085 246 GFINIEQNRIIKIFSVVSVVFLPPTLVASSYGMNFEFMPELKWSFGYPGAIILMILAGLAPYLYFKRKNWL 316
 
Name Accession Description Interval E-value
MtCorA-like cd12830
Mycobacterium tuberculosis CorA-like subfamily; This bacterial subfamily belongs to the ...
 31-325 1.50e-142

Mycobacterium tuberculosis CorA-like subfamily; This bacterial subfamily belongs to the Thermotoga maritima CorA (TmCorA)-like family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subfamily includes the Mg2+ transporter Mycobacterium tuberculosis CorA (which also transports Co2+). Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by a related protein, Saccharomyces cerevisiae Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213364 [Multi-domain]  Cd Length: 292  Bit Score: 404.21  E-value: 1.50e-142
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882  31 CFVWVALKDPEPDEIERMGEEFGLHELALEDARKGHQRPKIEEYGDALFAVLHTVE-IDGQGELQVGELNVFVGPNYVLS 109
Cdd:cd12830    1 GFVWVGLHEPDAEELAAVAEEFGLHELAVEDAVHAHQRPKLERYGDSLFLVLRTARyVDHTEEVETGETHVFVGPDFVVT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882 110 IRSHTEQDFRAVRARCEREPHLLKEGAAFVFYALMDQVVDRYFPTLEALGAELEALEDRIFEKTGtaaaRALIEDLYRLK 189
Cdd:cd12830   81 VRHGAAGPLARVRARLEADPELLALGPDAVLYAILDFIVDGYLPVAEELEDDVDELEEEVFSPDR----RDDIERIYRLK 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882 190 RRLVMLQQHTAPLVEPLAKLVGGRVPQVCAGMDHYFRDVYDHLLRIVRTIEGRREMLVTAIQVNLGMISLAENEVTKRLG 269
Cdd:cd12830  157 REVLEFRRAVDPLVEVLRRLARGHEPLIPKELRPYFRDVADHLLRVADRVDSLRELLSSALQANLALVSVQQNEDMRKIS 236

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 685665882 270 SFAALFAIPTMIAGIYGMNFNNIPELHWRFCFYVCLGVMAAADLFLWRRFRKAGWL 325
Cdd:cd12830  237 AWAAILAVPTAIAGIYGMNFDHMPELHWTYGYPLVLGLMVAVCLGLYRRFRRNGWL 292
CorA COG0598
Mg2+ and Co2+ transporter CorA [Inorganic ion transport and metabolism];
26-325 2.57e-114

Mg2+ and Co2+ transporter CorA [Inorganic ion transport and metabolism];


Pssm-ID: 440363 [Multi-domain]  Cd Length: 305  Bit Score: 332.95  E-value: 2.57e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882  26 VAKPECFVWVALKDPEPDEIERMGEEFGLHELALEDARKGHQRPKIEEYGDALFAVLHTVEID-GQGELQVGELNVFVGP 104
Cdd:COG0598    9 LLDPEGFVWIDLDGPTDEELEWLAEEFGLHPLALEDALDIEQRPKLEEYDDYLFIVLRTLNYNeEEEELETGPLSIFLGP 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882 105 NYVLSIRSHTEQDFRAVRARCEREPHLLKEGAAFVFYALMDQVVDRYFPTLEALGAELEALEDRIFEKTGtaaaRALIED 184
Cdd:COG0598   89 NFLITVRERPLDAFDDVRERLERGPGLLPRGPDYLLYALLDAIVDRYFPVLEELEDELDELEDELFESPD----NELLRR 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882 185 LYRLKRRLVMLQQHTAPLVEPLAKLVGGRVPQVCAGMDHYFRDVYDHLLRIVRTIEGRREMLVTAIQVNLGMISLAENEV 264
Cdd:COG0598  165 LYRLRRELVRLRRALAPLREVLSRLLRGESPLISEEDREYLRDVYDHLERLLEMVDSLRERLSGLLDAYLSLISNRQNEI 244

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 685665882 265 TKRLGSFAALFAIPTMIAGIYGMNFNNIPELHWRFCFYVCLGVMAAADLFLWRRFRKAGWL 325
Cdd:COG0598  245 MKVLTIIAAIFLPPTFIAGIYGMNFEGMPELDWPYGYPIVLGLMLLIAVLLYLYFKRKGWL 305
TmCorA-like cd12822
Thermotoga maritima CorA-like family; This family belongs to the MIT superfamily of essential ...
 34-325 1.42e-92

Thermotoga maritima CorA-like family; This family belongs to the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of the Thermotoga maritima CorA_like family are found in all three kingdoms of life. It is a functionally diverse family, in addition to the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, it includes three Saccharomyces cerevisiae members: two plasma membrane proteins, the Mg2+ transporter Alr1p/Swc3p and the putative Mg2+ transporter, Alr2p, and the vacuole membrane protein Mnr2p, a putative Mg2+ transporter. Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213356 [Multi-domain]  Cd Length: 289  Bit Score: 277.14  E-value: 1.42e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882  34 WVALKDPEPDEIERMGEEFGLHELALEDARKGHQRPKIEEYGDALFAVLHTVEID-GQGELQVGELNVFVGPNYVLSIRS 112
Cdd:cd12822    1 WIDLEGPTEEELQLLAEEFGFHPLAIEDALNERQRPKIEEYDDYLFLVLRALRYDeEELELETSELSIFLGKNFLVTVHE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882 113 HTEQDFRAVRARCEREPHLLKEGAAFVFYALMDQVVDRYFPTLEALGAELEALEDRIFEKtgtaAARALIEDLYRLKRRL 192
Cdd:cd12822   81 GPLRLIDEVIERLLSDPKLLPKGPDFLLYAILDAIVDSYFPILDELEDRLDELEDEILEE----PRREVLRELFALRREL 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882 193 VMLQQHTAPLVEPLAKLVGGRVPQVCAGMDHYFRDVYDHLLRIVRTIEGRREMLVTAIQVNLGMISLAENEVTKRLGSFA 272
Cdd:cd12822  157 LRLRRILSPQREVLNRLLRRENELISEELRPYFRDVYDHLERLAELLDSYRDLLSSLLDAYLSLQSNRTNEVMKVLTIIT 236

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 685665882 273 ALFAIPTMIAGIYGMNFNNIPELHWRFCFYVCLGVMAAADLFLWRRFRKAGWL 325
Cdd:cd12822  237 TIFLPLTFITGIYGMNFEYMPELHWPYGYFIVLGIMLLIAGGLLWWFRRKKWL 289
TmCorA-like_1 cd12828
Thermotoga maritima CorA_like subfamily; This subfamily belongs to the Thermotoga maritima ...
 40-325 9.07e-89

Thermotoga maritima CorA_like subfamily; This subfamily belongs to the Thermotoga maritima CorA (TmCorA)-family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of this subfamily are found in all three kingdoms of life. It is functionally diverse subfamily, in addition to the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, it includes Methanosarcina mazei CorA which may be involved in transport of copper and/or other divalent metal ions. Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by a related protein, Saccharomyces cerevisiae Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213362 [Multi-domain]  Cd Length: 294  Bit Score: 267.37  E-value: 9.07e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882  40 PEPDEIERMGEEFGLHELALEDARKGHQRPKIEEYGDALFAVLHTVEIDGQ-GELQVGELNVFVGPNYVLSIRSHTEQDF 118
Cdd:cd12828   11 HDIELIEKLGERFGLHPLVLEDILNTGQRPKVEEYDDYLFIVLKMLYYDEDtGELESEQVSLILGKNYVISFQERPGDVF 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882 119 RAVRARCERE-PHLLKEGAAFVFYALMDQVVDRYFPTLEALGAELEALEDRIFEKTGtaaaRALIEDLYRLKRRLVMLQQ 197
Cdd:cd12828   91 DPVRERLRNGkGRIRKKGADYLAYALLDAIVDNYFPVLEKLGDRIEDLEEELLENPT----PETLERIHKLKRELLFLRR 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882 198 HTAPLVEPLAKLVGGRVPQVCAGMDHYFRDVYDHLLRIVRTIEGRREMLVTAIQVNLGMISLAENEVTKRLGSFAALFaI 277
Cdd:cd12828  167 SIWPLREVINRLLRGESPLISEETRPYLRDVYDHTIQVIDTIETYRDMLSGLLDLYLSSVSNRMNEVMKVLTIISTIF-I 245

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 685665882 278 P-TMIAGIYGMNFNNIPELHWRFCFYVCLGVMAAADLFLWRRFRKAGWL 325
Cdd:cd12828  246 PlTFIAGIYGMNFEYMPELEWKYGYPAVLGVMLLIALGMLLYFKRKKWL 294
corA TIGR00383
magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); The article in Microb Comp ...
 33-325 9.86e-66

magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); The article in Microb Comp Genomics 1998;3(3):151-69 discusses this family and suggests that some members may have functions other than Mg2+ transport. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273048 [Multi-domain]  Cd Length: 318  Bit Score: 209.55  E-value: 9.86e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882   33 VWVALKDPEPDE-IERMGEEFGLHELALEDARKGHQRPKIEEYGDALFAVLHTVEIDGQGELQVGELNVFVGPNYVLSIR 111
Cdd:TIGR00383  28 LWIDLIEPTDEErLAKLGQFFAIHPLALEDILNSPQRPKVEEDEDHLFIISFFLNEDEDDTFETEQVSFILGKNLLFTIH 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882  112 SHTEQDFRAVRARCEREPHLLKEGAAFVFYALMDQVVDRYFPTLEALGAELEALEDRIFEKTgtaaARALIEDLYRLKRR 191
Cdd:TIGR00383 108 ERELPAFDSIRERIRTSQKVFEKGADYLLYDIFDAIIDSYFPLLENIEDELEELEDEIISGP----TSTLMDEILSLRTE 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882  192 LVMLQQHTAPLVEPLAKLV-GGRVPQVCAGMDHYFRDVYDHLLRIVRTIEGRREMLVTAIQVNLGMISLAENEVTKRLGS 270
Cdd:TIGR00383 184 LLALRRSLWPLRDVLNFLLrKTHLPIQTEEVREYLRDIYDHILSLLEMIETYRELLSSLMDLYLSLVNNKMNEIMKILTV 263

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 685665882  271 FAALFAIPTMIAGIYGMNFNNIPELHWRFCFYVCLGVMAAADLFLWRRFRKAGWL 325
Cdd:TIGR00383 264 VSTIFIPLTFIAGIYGMNFKFMPELNWKYGYPAVLIVMAVIALGPLIYFRRKGWL 318
CorA pfam01544
CorA-like Mg2+ transporter protein; The CorA transport system is the primary Mg2+ influx ...
 32-321 1.79e-58

CorA-like Mg2+ transporter protein; The CorA transport system is the primary Mg2+ influx system of Salmonella typhimurium and Escherichia coli. CorA is virtually ubiquitous in the Bacteria and Archaea. There are also eukaryotic relatives of this protein. The family includes the MRS2 protein from yeast that is thought to be an RNA splicing protein. However its membership of this family suggests that its effect on splicing is due to altered magnesium levels in the cell.


Pssm-ID: 460246 [Multi-domain]  Cd Length: 292  Bit Score: 189.83  E-value: 1.79e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882   32 FVWVALKDPEPDEIERMGEEFGLHELALEDARKGHQRPKIEEYGDALFAVLHTVEIDGQGELQV-GELNVFVGPNYVLSI 110
Cdd:pfam01544   4 FVWLDLDSPTEAELEWLARTLGLDPLALEDLLDPEERPRVEDYDDYFLLVLPGVNLDDSEEADElVTVSILLGDNFLITV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882  111 RSHTEQDFRAVRARCEREPHLLKeGAAFVFYALMDQVVDRYFPTLEALGAELEALEDRIFEKTgtaaARALIEDLYRLKR 190
Cdd:pfam01544  84 RHEPLPALDEVRKRLTLLGGGPL-DPGDLLYRLLDEIVDRFLELLEKLEDELDELEDELEDET----NNELLRELAALRR 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882  191 RLVMLQQHTAPLVEPLAKLVG-GRVPQVCAGMDHYFRDVYDHLLRIVRTIEGRREMLVTAIQVNLGMISLAENEVTKRLG 269
Cdd:pfam01544 159 SLVYLRRSLLPQRDVLNRLLRrEDDPLLDDEQKEYLRDLLDRLERLLEDLDALRERLRSLQDEYSSLLSERTNRVMKVLT 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 685665882  270 SFAALFAIPTMIAGIYGMNFNNIPELHWRFCFYVC--LGVMAAADLFLWRRFRK 321
Cdd:pfam01544 239 VVTAIFLPLTLITGIYGMNFGGLPELEWSYGYPFVliLGLMILLAILLLFYFRR 292
TmCorA-like_u2 cd12831
Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; This ...
 32-325 3.21e-55

Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; This subfamily belongs to the Thermotoga maritima CorA (TmCorA)-like family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of the TmCorA-like family are found in all three kingdoms of life. It is a functionally diverse family which includes the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, and three Saccharomyces cerevisiae proteins: two located in the plasma membrane: the Mg2+ transporter Alr1p/Swc3p and the putative Mg2+ transporter, Alr2p, and the vacuole membrane protein Mnr2p, a putative Mg2+ transporter. Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by a related protein, Saccharomyces cerevisiae Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213365 [Multi-domain]  Cd Length: 287  Bit Score: 181.21  E-value: 3.21e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882  32 FVWVALKDPEPDEIERMGEEFGLHELALEDARKGHQRPKIEEYGDALFAVLHTVEidgQGELQVGELNVFVGPNYVLSIR 111
Cdd:cd12831    2 WYWVDFNNPTEEEIKLLTSFFHFHPLAIEDCLHLLQRPKLDYYDDYQFLVLHAID---QEDLEAEEVNLFVGENYIVTFH 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882 112 SHTEQDFRAVRARCERePHLLKEGAAFVFYALMDQVVDRYFPtlealgaELEALEDRIFE---KTGTAAARALIEDLYRL 188
Cdd:cd12831   79 KEPIREINEVWEKLKE-KKDKKLGTLYIAYMIIDKIVDDYFP-------IVYEIEDRLNEiedNNVDSSNKKLMDEVFDI 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882 189 KRRLVMLQQHTAPLVEPLAKLVGGRVPQVCAGMDHYFRDVYDHLLRIVRTIEGRREMlvTA-IQVN-LGMISLAENEVTK 266
Cdd:cd12831  151 RSDLLKLRRTILPMRDLLYRILNSERLEGDKEQRAYFQDIYDHLLKLSEMLESNREM--TAdIRDNyESYNSNRMNSIMM 228

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 685665882 267 RLGSFAALFAIPTMIAGIYGMNFNNIPELHWRFCFYVCLGVMA--AADLFLWrrFRKAGWL 325
Cdd:cd12831  229 TLTIISTIFMPLTFIAGIYGMNFEYMPELKWHYGYFVVLGIMLliAIGMILW--FKKKGWF 287
MIT_CorA-like cd11744
metal ion transporter CorA-like divalent cation transporter superfamily; This superfamily of ...
 34-324 1.08e-38

metal ion transporter CorA-like divalent cation transporter superfamily; This superfamily of essential membrane proteins is involved in transporting divalent cations (uptake or efflux) across membranes. They are found in most bacteria and archaea, and in some eukaryotes. It is a functionally diverse group which includes the Mg2+ transporters of Escherichia coli and Salmonella typhimurium CorAs (which can also transport Co2+, and Ni2+ ), the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, and the Zn2+ transporter Salmonella typhimurium ZntB, which mediates the efflux of Zn2+ (and Cd2+). It includes five Saccharomyces cerevisiae members: i) two plasma membrane proteins, the Mg2+ transporter Alr1p/Swc3p and the putative Mg2+ transporter, Alr2p, ii) two mitochondrial inner membrane Mg2+ transporters: Mfm1p/Lpe10p, and Mrs2p, and iii) and the vacuole membrane protein Mnr2p, a putative Mg2+ transporter. It also includes a family of Arabidopsis thaliana members (AtMGTs), some of which are localized to distinct tissues, and not all of which can transport Mg2+. Thermotoga maritima CorA and Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, Mrs2p, and Alr1p. Natural variants such as GVN and GIN, as in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213354 [Multi-domain]  Cd Length: 286  Bit Score: 138.49  E-value: 1.08e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882  34 WVALKDPEPDEIERMGEEFGLHELALEDARKGHQRPKIEEYGDALFAVLHTVEIDGQG-ELQVGELNVFVGPNYVLSIRS 112
Cdd:cd11744    1 WIHCERLHDDDIRRVLEDNLHVPRALEDILLAESRPSFHPLDDNFMIILRGFNMDENAsPEDMLSVRILYFQGALISTRE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882 113 HTEQDFRAVRARCeREPHLLKEGAAFVFYALMDQVVDRYFPTLEALGAELEALEDRIFEKTGTAAARALIE---DLYRLK 189
Cdd:cd11744   81 IPSRAFMEIRQRL-REHSKGPKSAASLLNQLIEGLNGKIDLYLETIEETLNELDVNDEEGHYDESTYNHIAlqkALISIR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882 190 RRLVMLQQHTAPLVEPLAKLVGGRVpqvcagmdHYFRDVYDHLLRIVRTIEGRREMLVTAIQVNLGMISLAENEVTKRLG 269
Cdd:cd11744  160 RFIRPQQYALRDLIRSESELVTSRP--------HQYRFAHNNITRINETIEFYLGEVALLQDEIKHNRDEKTNKNSKLFT 231

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 685665882 270 SFAALFAIPTMIAGIYGMNFNNIPELHWRFCFY-VCLGVMAAAdLFLWRRFRKAGW 324
Cdd:cd11744  232 LVATIFLPTTFLAGLYGMNFEGMPGVESSMAFTwFCIALIVAF-GLEWLLFKRKGF 286
TmCorA-like_u3 cd12832
Uncharacterized subfamily of the Thermotoga maritima CorA-like family; This subfamily belongs ...
 34-325 2.03e-36

Uncharacterized subfamily of the Thermotoga maritima CorA-like family; This subfamily belongs to the Thermotoga maritima CorA (TmCorA)-like family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of the TmCorA-like family are found in all three kingdoms of life. It is a functionally diverse family which includes the CorA Co2+ transporter from the hyperthermophilic Thermotoga maritima, and three Saccharomyces cerevisiae proteins: two located in the plasma membrane: the Mg2+ transporter Alr1p/Swc3p and the putative Mg2+ transporter, Alr2p, and the vacuole membrane protein Mnr2p, a putative Mg2+ transporter. Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by a related protein, Saccharomyces cerevisiae Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213366 [Multi-domain]  Cd Length: 287  Bit Score: 132.34  E-value: 2.03e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882  34 WVALKDPEPDEIERMGEEFGLHELALEDA-RKGHQrPKIEEYGDALFAVLHTVEIDGQGELQ-VGELN----VFVGPNYV 107
Cdd:cd12832    1 WIDVVAPTEEDLEDLARRYNLHETSLKDClDPDHL-PKYEEVDGVTFIILRVYTDKKRENADtIQELTtkiaIFVVDKFV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882 108 LSI-RSHTEQdFRAVRARCEREPHLlKEGAAFVFYALMDQVVDRYFPTLEALGAELEALEDRIFEKTGTaaaRALIEDLY 186
Cdd:cd12832   80 ITIhRTDLEF-IANLKEKWLSGMHK-CESPTELLLRIVKDALKTYEAPLEKLSEELDKYEEEVFLKKRK---GSLLKRLY 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882 187 RLKRR-------LVMLQQHTAPLVEPLAKLVggrvpqvcagmdhYFRDVYDHLLRIVRTIEGRREMLVTAIQVNLGMISL 259
Cdd:cd12832  155 HLKRKasvikrvLNLTQDVIDKIDTPLKSDP-------------YTQDLRDLLIKLLSLYDELHENATNLLSLYISLSSQ 221

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 685665882 260 AENEVTKRLGSFAALFAIPTMIAGIYGMNFNNIPELHWRFCFYVCLGVMAA--ADLFLWrrFRKAGWL 325
Cdd:cd12832  222 RTNEVMRVLTIFSVFFLPLTFIAGVYGMNFKYMPELHWKYGYPATLLVMIVivVGIYFW--FKRKGWL 287
Alr1p-like cd12829
Saccharomyces cerevisiae Alr1p-like subfamily; This eukaryotic subfamily belongs to the ...
 34-319 2.35e-34

Saccharomyces cerevisiae Alr1p-like subfamily; This eukaryotic subfamily belongs to the Thermotoga maritima CorA (TmCorA)-family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subfamily includes three Saccharomyces cerevisiae members: two plasma membrane proteins, the Mg2+ transporter Alr1p/Swc3p and the putative Mg2+ transporter, Alr2p, and the vacuole membrane protein Mnr2p, a putative Mg2+ transporter. Thermotoga maritima CorA forms funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport by Alr1p. Natural variants in this signature sequence may be associated with the transport of different divalent cations. The functional diversity of the MIT superfamily may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213363 [Multi-domain]  Cd Length: 305  Bit Score: 127.38  E-value: 2.35e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882  34 WVALKDPEPDEIERMGEEFGLHELALEDARKGHQRPKIEEYGDALFAVLHTVEIDGQ-GELQVGELNVF--VGPNYVLSI 110
Cdd:cd12829    1 WLDVQSPTDDDMRAIGKLFPIHPLTLEDILSQDTREKVELFPNYYFISFRAIESDSElDENVLEPVNVYivVFREGILTF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882 111 RSHTEQDFRAVRARCEREPHLLKEGAAFVFYALMDQVVDRYFPTLEALGAELEALEDRIFEKTGTAAARALIeDLYRLKR 190
Cdd:cd12829   81 HFKPLDHIERVRKRIRLLSDSHLLSSDWVLYALLDSIVDSFFPLVDSIEKEVDSIDELVLLISSSDQSDLLR-RIGDLRR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882 191 RLVMLQQHTAP---LVEPLAKLVGGRVPQVCAGMDH-YFRDVYDHLLRIVRTIEGRREMLVTA-----IQVNLGMI--SL 259
Cdd:cd12829  160 RVTSLLRLLFAksdVLKQLLKRLMKKTFVSPDSEVAiYLGDVQDHILTLLQKLNHYEDLLSRShsnylAQLSLEMSqeSN 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 685665882 260 AENEVTKRLGSFAALFAIPTMIAGIYGMN----FNNIP--ELHWRFCFYVCLGVMAAADLFLWRRF 319
Cdd:cd12829  240 GTDKAMLRLTVIATIFLPLQLITGLFGMNvkvpGQDIEslYWFFGIVIVAIMVLVAIVVVFLVRRW 305
EcCorA-like_u1 cd12837
uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; A ...
 33-325 9.52e-32

uncharacterized subgroup of the Escherichia coli Mg2+ transporter CorA_like subfamily; A uncharacterized subgroup of the Escherichia coli CorA-Salmonella typhimurium ZntB_like family (EcCorA_ZntB-like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. The EcCorA_ZntB-like family includes the Mg2+ transporters Escherichia coli and Salmonella typhimurium CorAs, which can also transport Co2+, and Ni2+. Structures of the intracellular domain of EcCorA_ZntB-like family members, Vibrio parahaemolyticus and Salmonella typhimurium ZntB, form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213371 [Multi-domain]  Cd Length: 298  Bit Score: 120.33  E-value: 9.52e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882  33 VWVALKDPEPDEIERMGEEFGLHELALEDARKghqrpkIEE----Y--GDALF---AVLHTVEidgQGELQVGELNVFVG 103
Cdd:cd12837    1 VWIDLLNPTPEEEAAVEALLGIAIPTREEMSE------IEAssrlYreGGALYmtaPLLSRAD---TDDPELSPVTFVLT 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882 104 PNYVLSIRSHTEQDFRAVRARCEREPHLLKEGAAfVFYALMDQVVDRYFPTLEALGAELEALEDRIFE------KTGTAA 177
Cdd:cd12837   72 PERLVTVRYADPRAFDTFAARAARQPSGCASGED-VLLGLLEAIVDRLADVLERVGADLDRLSRRIFRssakrrRRASRD 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882 178 ARALIEDLYRLKRRLvmlqqhtaplveplaklvgGRVPQVCAGMDH---YFRDVYDH------------LLRIVRTIE-- 240
Cdd:cd12837  151 LRSVLRRIGRAGDLL-------------------SKIRESLLSLGRllsFLSANAADwlskelrarlktLQRDVASLSeh 211

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882 241 -----GRREMLVTAIqvnLGMISLAENEVTKRLGSFAALFAIPTMIAGIYGMNFNNIPELHWRFCFYVCLGVMAAADL-- 313
Cdd:cd12837  212 atflsNKIQFLLDAT---LGLINIEQNNIIKIFSVASVVFLPPTLIASIYGMNFKHMPELDWPFGYPLALGLMVLSAVlp 288

                        330
                 ....*....|..
gi 685665882 314 FLWrrFRKAGWL 325
Cdd:cd12837  289 LLW--FKRRGWL 298
EcCorA_ZntB-like cd12821
Escherichia coli CorA-Salmonella typhimurium ZntB_like family; A family of the MIT superfamily ...
 34-324 2.35e-26

Escherichia coli CorA-Salmonella typhimurium ZntB_like family; A family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. Members of this family are found in all three kingdoms of life. It is a functionally diverse family, including the Mg2+ transporters Escherichia coli and Salmonella typhimurium CorAs (which can also transport Co2+, and Ni2+ ), and the Zn2+ transporter Salmonella typhimurium ZntB which mediates the efflux of Zn2+ (and Cd2+). It also includes two Saccharomyces cerevisiae members: the inner membrane Mg2+ transporters Mfm1p/Lpe10p, and Mrs2p, and a family of Arabidopsis thaliana members (AtMGTs) some of which are localized to distinct tissues, and not all of which can transport Mg2+. Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213355 [Multi-domain]  Cd Length: 285  Bit Score: 105.48  E-value: 2.35e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882  34 WVALKDPEpDEIERMGEEFGLHEL--ALEDARKGHQRPKIEE-YGDALFAVLHTVEIDGQGELqvgeLNVFVGPNYVLSI 110
Cdd:cd12821    1 WYDIDEPD-DEIRRLLEELESSHLpnDLRDILLGVSFPRFEEvSGSGIYIQLRKPQKDADTAS----FHFLITRDRLITV 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882 111 RshteqdFRAVRARCEREPHLLKEGAAFVFYA------LMDQVVDRYFPTLEALGAELEALEDRIFEKTGtaaaRALIED 184
Cdd:cd12821   76 R------LDELPALDELRQDLRSGQMKSAKSAaellfvLLGAIIKALLTGIDQFEEKLEELEWDLLEGNN----AIKLDR 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882 185 LYRLKRRLVMLQQHTAPLVEPLAKLVGGRVPQVCAGMDHYFRDVYDHLLRIVRTIEGRREMLVTAIQVNLGMISLAENEV 264
Cdd:cd12821  146 ILELRRELLRLTNLIEPQQEVLMALQEAFAELLFSEDEEELRRTLDRIERLLQLIEEYEQELDTLQDIEEVVSSHRGNEI 225

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882 265 TKRLGSFAALFAIPTMIAGIYGMNFNNIPELHWRFCFYVCLGVMAAADLFLWRRFRKAGW 324
Cdd:cd12821  226 MKTLTVVTTVFLPLTLIGGLWGMNFKNMPELEWKYGYLFVLGLIILSTAGLYLYLRRKGW 285
EcCorA-like cd12825
Escherichia coli Mg2+ transporter CorA_like subfamily; A bacterial subfamily of the ...
 34-325 6.47e-21

Escherichia coli Mg2+ transporter CorA_like subfamily; A bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB_like(EcCorA_ZntB-like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subfamily includes the Mg2+ transporters Escherichia coli, Salmonella typhimurium, and Helicobacter pylori CorAs (which can also transport Co2+, and Ni2+). Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213359 [Multi-domain]  Cd Length: 287  Bit Score: 90.45  E-value: 6.47e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882  34 WVALKDPEPDEIERMGEEFGLHELALEDARKGHQRPKIEEYGDALFAVLHTVEIDGQGELQVGELNVFVGPNYVLSIRSH 113
Cdd:cd12825    1 WIDLINPTEEELATLSSEYGFILPPREHLEDIEISSRYWEDDSQLFITLSFPNQTKEDTIEEEPVTFIIKGNILFTIRYR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882 114 TEQDFRAVRARCEREPHLLKEGA---AFVFYALMDQVVDRyfptLEALGAELEALEDRIFEKTGTAaaRALIEDLYRLKR 190
Cdd:cd12825   81 DLPAFDIFPKRAFSQRKFFNSGEelfLFLFEVIVDYLADI----LENISKKIKQLSREILEEKQFS--EEDLDALTKLNE 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882 191 RLVMLQQHTAPLVEPLAKLVggRVPQVCAGMDHYFRDVYDHLLRIVRTIEGRREMLVTAIQVNLGMISLAENEVTKRLGS 270
Cdd:cd12825  155 NNITLRESLIEKQRIITLLL--KSPRENSDTKEKLKIELRDLSSLLDHTTFNFDKLDDLKNNILGKIELEQNKIIKIFTV 232

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 685665882 271 FAALFAIPTMIAGIYGMNFNNIPELHWRFCFYVCLGVMAAADLFLWRRFRKAGWL 325
Cdd:cd12825  233 VTVCFLPPTLIASIYGMNFKNMPELKWSYGYPFALILMILSTILPLLYFKRKGWL 287
EcCorA-like_1 cd12835
Escherichia coli Mg2+ transporter CorA_like subgroup; A bacterial subgroup of the Escherichia ...
 34-325 5.37e-19

Escherichia coli Mg2+ transporter CorA_like subgroup; A bacterial subgroup of the Escherichia coli CorA-Salmonella typhimurium ZntB_like (EcCorA_ZntB-like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subgroup includes the Mg2+ transporters Escherichia coli CorA and Salmonella typhimurium CorA (which can also transport Co2+, and Ni2+). Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213369  Cd Length: 287  Bit Score: 85.39  E-value: 5.37e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882  34 WVALKDPEPDEIERMGEEFGLhELaledarkghqrPKIEEYGDALFAVLHTVEIDG---------QGELQVGELNV-F-V 102
Cdd:cd12835    1 WIDLIAPDDEEREWLEQLLGQ-EL-----------PDLEDLEEIEASARFYVDEDGlhihslflqDSEGRARNVTVaFtL 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882 103 GPNYVLSIRSHTEQDFRAVRARCEREPHLLKeGAAFVFYALMDQVVDRYFPTLEALGAELEALEDRIFEKTGTAAARAL- 181
Cdd:cd12835   69 RDDRLITLREEELPVFRLLRLRARRGPGEVS-DPKDLLLDLFEQKVEYLADIIEDIYRDLERVSREVLEENDEDLEEALg 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882 182 ----IEDLYRLKRRLVMLQQHTaplvepLAKLVGGRVPQvcagmDHYFRDVyDHLLRIVRTIEGRREMLVTAI----QVN 253
Cdd:cd12835  148 rlarQEDLNGKIRLCLMDTQRA------LSFLLRTRRLS-----DEQLEDA-REILRDIESLLPHTQFLFDKInflmDAA 215

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 685665882 254 LGMISLAENEVTKRLGSFAALFAIPTMIAGIYGMNFNNIPELHWRFCFYVCLGVMAAADLFLWRRFRKAGWL 325
Cdd:cd12835  216 MGFINIEQNKIIKIFSVAAVVFLPPTLIASIYGMNFDFMPELDWKFGYPMAIGLMILSAIAPYLYFKRKGWL 287
HpCorA-like cd12836
Mg2+ transporter Helicobacter pylori CorA-like subgroup; A bacterial subgroup of the ...
 254-325 1.23e-15

Mg2+ transporter Helicobacter pylori CorA-like subgroup; A bacterial subgroup of the Escherichia coli CorA-Salmonella typhimurium ZntB_like (EcCorA_ZntB-like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subgroup includes the Mg2+ transporter Helicobacter pylori CorAs (which can also transport Co2+, and Ni2+); CorA plays an important role in the viability of this pathogen. Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB (members of the EcCorA_ZntB-like family) form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213370 [Multi-domain]  Cd Length: 288  Bit Score: 75.76  E-value: 1.23e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 685665882 254 LGMISLAENEVTKRLGSFAALFAIPTMIAGIYGMNFNNIPELHWRFCFYVCLGVMAAADLFLWRRFRKAGWL 325
Cdd:cd12836  217 LGLINIEQNKIIKIFTVATVIFMPPTLIASIYGMNFKFMPELDWKYGYPFALLLMVISSILPLLYFKKKKWL 288
EcCorA_ZntB-like_u2 cd12827
uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB ...
 34-325 8.56e-14

uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; A uncharacterized subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB (EcCorA-ZntB_like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes.The EcCorA-ZntB-like family includes the Mg2+ transporters Escherichia coli and Salmonella typhimurium CorAs, which can also transport Co2+, and Ni2+. Structures of the intracellular domain of EcCorA-ZntB-like family members, Vibrio parahaemolyticus and Salmonella typhimurium ZntB, form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA. Natural variants such as GVN and GIN, such as occur in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213361 [Multi-domain]  Cd Length: 289  Bit Score: 70.61  E-value: 8.56e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882  34 WVALKDPEPDEIERMGEEFGLHELALEDARKGHQRPKIEEYGD--ALFAVLHTVEIDGQGELQ-----VGelnVFVGPNY 106
Cdd:cd12827    1 WINVVNPTEEEIEQLAEKYGIPEDFLTYALDEEERSRIEYDDDtdYLLIILDVPVEEEEDDDEyetipLG---IILTKDR 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882 107 VLSIRSHTEQDFRAVRARCEREPHLLKEgAAFVFYaLMDQVVDRYFPTLEALGAELEALEDRIFEKTGTaaaRALIEdLY 186
Cdd:cd12827   78 LITICNHETDLLDDFLEGRVKNFDTSSK-TRFLLQ-ILYRIATSYLKYLRQINKERDELEQELRKSTKN---KELFQ-LL 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882 187 RLKRRLVML-----QQHTAplvepLAKLVGGRVPQvcagMDHYFRDVYDHLLrivrtIEGR--REMlvTAIQVNL----- 254
Cdd:cd12827  152 DLEKSLVYFstslkSNEIV-----LEKLKRSRSLK----LDEEDKELLEDVI-----IENKqaIEM--AEIYSDIlsglm 215

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 685665882 255 ----GMIS--LaeNEVTKRLGSFAALFAIPTMIAGIYGMNFnNIPELHWRFCFYVCLGVMAAADLFLWRRFRKAGWL 325
Cdd:cd12827  216 dafaSVISnnL--NNVMKFLTSITIVLTIPTIITGFYGMNV-PLPFADSPYAFWIILLISLLLSVIVALILRRKKYF 289
ZntB-like_1 cd12833
Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; A bacterial subgroup belonging to ...
 32-325 1.80e-13

Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; A bacterial subgroup belonging to the Escherichia coli CorA-Salmonella typhimurium ZntB_like family (EcCorA_ZntB-like) of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subgroup includes the Zn2+ transporter Salmonella typhimurium ZntB which mediates the efflux of Zn2+ (and Cd2+). Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, which occur in proteins belonging to this subfamily, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213367 [Multi-domain]  Cd Length: 290  Bit Score: 69.44  E-value: 1.80e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882  32 FVWVALKDPEPDEIERMGEEFGLHELALEDARKGHQRPKIEEYGDALFAVLHTVEIDgqgELQVGE----LNVFVGPNYV 107
Cdd:cd12833    2 FLWLHLDYSDPEAQDWLEQSSGLPELVIDALLAEETRPRATRLGDGLLLNLRGVNLN---PGADPEdmvsIRLWITPGRI 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882 108 LSIRshtEQDFRAVRARCERephlLKEG------AAFVfYALMDQVVDRYFPTLEALGAELEALEDRIFEKtgtaAARAL 181
Cdd:cd12833   79 ISTR---RRRLLAVDDIREA----LEAGkgpkspGDFL-AALAERLTDRMEDVIDELEDRLDELEERVLEE----EDEEL 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882 182 IEDLYRLKRRLVMLQQHTAPLVEPLAKLVGGRVPQVCAGMDHYFRDVYDHLLRIVRTIEGRRE-MLVTAIQVNlGMISLA 260
Cdd:cd12833  147 RGELAELRRQAIALRRYLAPQRDALERLAREDLPWLSDDDRLRLREAADRLTRYIEDLDAIRErAAVLQEELT-NRRAEQ 225

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 685665882 261 ENEVTKRLGSFAALFAIPTMIAGIYGMNFNNIP--ELHWRFcFYVC--LGVMAAAdLFLWrrFRKAGWL 325
Cdd:cd12833  226 MNRRMYVLSIVAAIFLPLGFLTGLLGINVGGIPgaENPWAF-WIFCglLVVLAVG-LLLL--FRRKKWL 290
PRK11085 PRK11085
magnesium/cobalt transporter CorA;
33-325 3.31e-11

magnesium/cobalt transporter CorA;


Pssm-ID: 182951  Cd Length: 316  Bit Score: 63.20  E-value: 3.31e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882  33 VWVALKDPEPDEIERMGEEFG---LHELALEDArKGHQRPKIEEYGDALFAVLHTVEIDGQGELQVGELNVFVGPNYVLs 109
Cdd:PRK11085  27 VWIDLVEPDDDERLRVQSELGqslATRPELEDI-EASARFFEDEDGLHIHSFFFFEDAEDHAGNSTVAFTIRDGRLFTL- 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882 110 iRSHTEQDFRAVRARCEREphLLKEGAAF-----VFYALMDQVVDryfpTLEALGAELEALEDRIFE-KTGTAAARAL-- 181
Cdd:PRK11085 105 -RERELPAFRLYRMRARSQ--TLVDGNAYellldLFETKIEQLAD----EIENIYSDLEKLSRVIMEgHQGDEYDEALst 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882 182 ---IEDLYRLKRRLVMLQQHTAPLVEPLAKLVGGRVPQVcagmdhyfRDVydhlLRIVRTIEGRREMLVTAI----QVNL 254
Cdd:PRK11085 178 laeLEDIGWKVRLCLMDTQRALNFLVRKARLPGGQLEQA--------REI----LRDIESLLPHNESLFQKVnflmQAAM 245

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 685665882 255 GMISLAENEVTKRLGSFAALFAIPTMIAGIYGMNFNNIPELHWRFCFYVCLGVMAAADLFLWRRFRKAGWL 325
Cdd:PRK11085 246 GFINIEQNRIIKIFSVVSVVFLPPTLVASSYGMNFEFMPELKWSFGYPGAIILMILAGLAPYLYFKRKNWL 316
ZntB_u1 cd12834
Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like ...
 48-318 3.28e-09

Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; The MIT superfamily of essential membrane proteins is involved in transporting divalent cations (uptake or efflux) across membranes. The ZntB-like subfamily includes the Zn2+ transporter Salmonella typhimurium ZntB which mediates the efflux of Zn2+ (and Cd2+). Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN which occur in proteins belonging to this subfamily, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213368 [Multi-domain]  Cd Length: 290  Bit Score: 56.83  E-value: 3.28e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882  48 MGEEFGLHELALEDARKGHQRPKIEEYGDALFAVLHTVEID-GQGELQVGELNVFVGPNYVLSIRSHTEQDFRAVRARce 126
Cdd:cd12834   18 IAAHPALPEAARALLLSGDTSTRLEVDDDALYGVLNDLERDfAEASTDVGTLRFAVTPRLLITARRQPLRSVDRLRQA-- 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882 127 rephlLKEGAAF-----VFYALMDQVVDRYFPTLEALGAELEALEDRIFEKTGTAAARALIedlyRLKRRLVMLQQHTAP 201
Cdd:cd12834   96 -----VERGLRFrspadLLEHLLREQADTLSRIVRELTDELDRIEDRLLSGRLRRERRELG----ALRRRLVRLHRLLAP 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882 202 LVEPLAKLVGGRVPQVCAGMDHYFRDVYDHLLRIVRTIEGRRE---MLVTAIQVNLgmislaeNEVTKR----LGSFAAL 274
Cdd:cd12834  167 EPAALFRLLRRPPDWLPDADLETLRRLTERLDALDRDLVALQErarLLQEEIAARL-------AEQTNRslyiLSVVTAL 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 685665882 275 FAIPTMIAGIYGMNFNNIPELHWRFCFY----VCLGVMAAADLFLWRR 318
Cdd:cd12834  240 LLPPTLVTGLFGMNTGGLPLAEGPHGFWiavaLALLAAGLAYLLLRRL 287
EcCorA_ZntB-like_u1 cd12826
uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB ...
 42-299 2.64e-08

uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; A uncharacterized subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB (EcCorA-ZntB_like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. The EcCorA-ZntB_like family includes the Mg2+ transporters Escherichia coli and Salmonella typhimurium CorAs, which can also transport Co2+, and Ni2+. Structures of the intracellular domain of EcCorA-ZntB_like family members, Vibrio parahaemolyticus and Salmonella typhimurium ZntB, form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA. Natural variants such as GVN and GIN, as in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213360  Cd Length: 281  Bit Score: 54.11  E-value: 2.64e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882  42 PDEIERMGEEFGLHELALEDARKGHQRpKIEEYGDAL---FAVLHTVEIDGQ----GELQVGELNVFVGPNyvlsirSHT 114
Cdd:cd12826    6 LEEFRELKELFGLKKELLESLESIRFC-KAEVFEDCLggtFGIPDKLDVLGKrdrfGFYITKNRLVFIDDD------GFV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882 115 EQDFRAVRarceREPHLLKEGAAFVFYALMDQVVDRYFPTLEALGAELEALEDRIFEKTgtaaARALIEDLYRLKRRLVM 194
Cdd:cd12826   79 LKLLERIQ----EKKSWKGPSLERFLYDFLEYLIKDDLEYLEKYEEKLEELEEEILDGK----LKNFNERILKIRKELLR 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882 195 LQQHTAPLVEplaklvggrvpqVCAGMDHYFRDVYDHL-LRIVRTIEGR------------------REMLVTAIQVNLg 255
Cdd:cd12826  151 LNSYYEQLMD------------IGEELEENENDLFDEEeLRLFRLFSDRverlhdnvqmlreyslqiRELYQSQIDIRQ- 217

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 685665882 256 mislaeNEVTKRLGSFAALFAIPTMIAGIYGMNFNNIPELHWRF 299
Cdd:cd12826  218 ------NRIMKILTVVTTIFLPLTLITGWYGMNFTNMPELHWKY 255
ZntB-like cd12824
Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; A bacterial subfamily belonging ...
 32-321 6.38e-08

Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; A bacterial subfamily belonging to the Escherichia coli CorA-Salmonella typhimurium ZntB_like family (EcCorA_ZntB-like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This subfamily includes the Zn2+ transporter Salmonella typhimurium ZntB which mediates the efflux of Zn2+ (and Cd2+). Structures of the intracellular domain of Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, which occur in proteins belonging to this subfamily, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213358 [Multi-domain]  Cd Length: 290  Bit Score: 52.91  E-value: 6.38e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882  32 FVWVALKDPEPDEIERMGEEFGLHELALEDARKGHQRPKIEEYGDALFAVLHTVEIDGQGEL-QVGELNVFVGPNYVLSI 110
Cdd:cd12824    2 NTWYHCDRADPAIRSWLEDNTHLPEATVDHLLAPVRFPHFEPVDDGFLLSLRGIRMDEAASPsDMADLRILIGQGAAVTV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882 111 RShteQDFRAV----RARCEREPhlLKEGAAFVFYAL--MDQVVDRYFPTLEAlgaELEALEDRIfEKTGTAAAR----A 180
Cdd:cd12824   82 RS---GPSRAVdelrRALRDHSS--LKSLADLLAQMIsgMTKRLELVIFDLTE---TLDEVEDNL-LDGGTAPPPyaliA 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882 181 LIEDLYRLKRRLVMLQQHTAPLVEPLAKLVGGRVPqvcagmdHYFRDVYDHLLRIVRTIE---GRREMLVTAIQVNlgmi 257
Cdd:cd12824  153 LQRRLFRIRRQIRPQQQALRPLITDPAELLVTSDR-------ETLRRASNNVTRYLETLDfcrTRVALLQDEIKAQ---- 221

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685665882 258 slaENEVTKR----LGSFAALFAIPTMIAGIYGMNFNNIPELH--WRFCFYVCLGVMAAADLFLWRRFRK 321
Cdd:cd12824  222 ---RDEKTTRssllLTVVATVFLPLTFITGLLGMNVGGIPDVEspMGFWWVTGLSILVALLAWLLLRRLG 288
Mrs2_Mfm1p-like cd12823
Saccharomyces cerevisiae inner mitochondrial membrane Mg2+ transporters Mfm1p and Mrs2p-like ...
 267-319 2.76e-03

Saccharomyces cerevisiae inner mitochondrial membrane Mg2+ transporters Mfm1p and Mrs2p-like family; A eukaryotic subfamily belonging to the Escherichia coli CorA-Salmonella typhimurium ZntB_like family (EcCorA_ZntB-like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This functionally diverse subfamily includes the inner mitochondrial membrane Mg2+ transporters Saccharomyces cerevisiae Mfm1p/Lpe10p, Mrs2p, and human MRS2/ MRS2L. It also includes a family of Arabidopsis thaliana proteins (AtMGTs) some of which are localized to distinct tissues, and not all of which can transport Mg2+. Structures of the intracellular domain of two EcCorA_ZntB-like family transporters: Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, as in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213357  Cd Length: 323  Bit Score: 39.15  E-value: 2.76e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 685665882 267 RLGSFAALFAIPTMIAGIYGMNFNNIPELHWRFCFYVCLGVMAAAdLFLWRRF 319
Cdd:cd12823  263 KLSIGTLSLAVGTLVAGLFGMNLPSGLEESPYAFWIVTGGSVVGS-ILIFIVV 314
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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