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Conserved domains on  [gi|675333968|gb|AIL68483|]
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hypothetical protein IJ09_12020 [Listeria monocytogenes]

Protein Classification

beta/alpha barrel domain-containing protein( domain architecture ID 229392)

beta/alpha barrel domain-containing protein belongs to a large superfamily with a wide variety of enzymatic functions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIM super family cl21457
TIM-like beta/alpha barrel domains; A large family of domains similar to triose phosphate ...
 1-284 3.67e-160

TIM-like beta/alpha barrel domains; A large family of domains similar to triose phosphate isomerase (TIM) which, in general, share an eight beta/alpha closed barrel structure.


The actual alignment was detected with superfamily member PRK07709:

Pssm-ID: 473867  Cd Length: 285  Bit Score: 446.81  E-value: 3.67e-160
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968   1 MPIVNMTDMLKKALAGKYAVGQFNINNLEWTQAILKAAEAEKAPVILGVSEGAAKYMGGFKTVVKMTEGLVEDLKITVPV 80
Cdd:PRK07709   1 MPLVSMKEMLNKALEGKYAVGQFNMNNLEWTQAILAAAEEEKSPVILGVSEGAARHMTGFKTVVAMVKALIEEMNITVPV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968  81 AIHLDHGSSFDSCKAAIDAGFSSVMIDGSHHPIDENIAMTKQVVDYAHAKGVSVEAEIGTVGGDEDGVTG-GINYADPQE 159
Cdd:PRK07709  81 AIHLDHGSSFEKCKEAIDAGFTSVMIDASHHPFEENVETTKKVVEYAHARNVSVEAELGTVGGQEDDVIAeGVIYADPAE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968 160 CLRVVKEANIDALAAALGSVHGPYHGEPVLGFDEMKEISELTGAPLVLHGGSGIPEHQIKKAIELGHSKINVNTECQIVW 239
Cdd:PRK07709 161 CKHLVEATGIDCLAPALGSVHGPYKGEPNLGFAEMEQVRDFTGVPLVLHGGTGIPTADIEKAISLGTSKINVNTENQIEF 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 675333968 240 TAAVREKLATDDKVYDPRKVIGPGVDAIIKTVTEKIQEFGSNGKA 284
Cdd:PRK07709 241 TKAVREVLNKDQEVYDPRKFIGPGRDAIKATVIGKIREFGSNGKA 285
 
Name Accession Description Interval E-value
PRK07709 PRK07709
fructose-bisphosphate aldolase; Provisional
 1-284 3.67e-160

fructose-bisphosphate aldolase; Provisional


Pssm-ID: 169068  Cd Length: 285  Bit Score: 446.81  E-value: 3.67e-160
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968   1 MPIVNMTDMLKKALAGKYAVGQFNINNLEWTQAILKAAEAEKAPVILGVSEGAAKYMGGFKTVVKMTEGLVEDLKITVPV 80
Cdd:PRK07709   1 MPLVSMKEMLNKALEGKYAVGQFNMNNLEWTQAILAAAEEEKSPVILGVSEGAARHMTGFKTVVAMVKALIEEMNITVPV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968  81 AIHLDHGSSFDSCKAAIDAGFSSVMIDGSHHPIDENIAMTKQVVDYAHAKGVSVEAEIGTVGGDEDGVTG-GINYADPQE 159
Cdd:PRK07709  81 AIHLDHGSSFEKCKEAIDAGFTSVMIDASHHPFEENVETTKKVVEYAHARNVSVEAELGTVGGQEDDVIAeGVIYADPAE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968 160 CLRVVKEANIDALAAALGSVHGPYHGEPVLGFDEMKEISELTGAPLVLHGGSGIPEHQIKKAIELGHSKINVNTECQIVW 239
Cdd:PRK07709 161 CKHLVEATGIDCLAPALGSVHGPYKGEPNLGFAEMEQVRDFTGVPLVLHGGTGIPTADIEKAISLGTSKINVNTENQIEF 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 675333968 240 TAAVREKLATDDKVYDPRKVIGPGVDAIIKTVTEKIQEFGSNGKA 284
Cdd:PRK07709 241 TKAVREVLNKDQEVYDPRKFIGPGRDAIKATVIGKIREFGSNGKA 285
fruc_bis_ald_ TIGR01859
fructose-1,6-bisphosphate aldolase, class II, various bacterial and amitochondriate protist; ...
 3-284 3.78e-155

fructose-1,6-bisphosphate aldolase, class II, various bacterial and amitochondriate protist; This model represents of one of several subtypes of the class II fructose-1,6-bisphosphate aldolase, an enzyme of glycolysis. The subtypes are split into several models to allow separation of a family of tagatose bisphosphate aldolases. This form is found in Gram-positive bacteria, a variety of Gram-negative, and in amitochondriate protists. The class II enzymes share homology with tagatose bisphosphate aldolase but not with class I aldolase. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 130918  Cd Length: 282  Bit Score: 433.71  E-value: 3.78e-155
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968    3 IVNMTDMLKKALAGKYAVGQFNINNLEWTQAILKAAEAEKAPVILGVSEGAAKYMGGFKTVVKMTEGLVEDLKItVPVAI 82
Cdd:TIGR01859   1 LVNGKEILQKAKKEGYAVGAFNFNNLEWTQAILEAAEEENSPVIIQVSEGAIKYMGGYKMAVAMVKTLIERMSI-VPVAL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968   83 HLDHGSSFDSCKAAIDAGFSSVMIDGSHHPIDENIAMTKQVVDYAHAKGVSVEAEIGTVGGDEDGVTG-GINYADPQECL 161
Cdd:TIGR01859  80 HLDHGSSYESCIKAIKAGFSSVMIDGSHLPFEENLALTKKVVEIAHAKGVSVEAELGTLGGIEDGVDEkEAELADPDEAE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968  162 RVVKEANIDALAAALGSVHGPYHGEPVLGFDEMKEISELTGAPLVLHGGSGIPEHQIKKAIELGHSKINVNTECQIVWTA 241
Cdd:TIGR01859 160 QFVKETGVDYLAAAIGTSHGKYKGEPGLDFERLKEIKELTNIPLVLHGASGIPEEQIKKAIKLGIAKINIDTDCRIAFTA 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 675333968  242 AVREKLATDDKVYDPRKVIGPGVDAIIKTVTEKIQEFGSNGKA 284
Cdd:TIGR01859 240 AIRKVLTEKKDEYDPRKILGPAREAIKETVKEKMRLFGSAGKA 282
Fba COG0191
Fructose/tagatose bisphosphate aldolase [Carbohydrate transport and metabolism]; Fructose ...
 2-284 9.68e-152

Fructose/tagatose bisphosphate aldolase [Carbohydrate transport and metabolism]; Fructose/tagatose bisphosphate aldolase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439961  Cd Length: 283  Bit Score: 425.27  E-value: 9.68e-152
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968   2 PIVNMTDMLKKALAGKYAVGQFNINNLEWTQAILKAAEAEKAPVILGVSEGAAKYMGgFKTVVKMTEGLVEdlKITVPVA 81
Cdd:COG0191    1 MLVSLKELLDKAKEGGYAVPAFNVNNLETLQAILEAAEELNSPVILQVSEGAAKYAG-LEYLAAMVRAAAE--EASVPVA 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968  82 IHLDHGSSFDSCKAAIDAGFSSVMIDGSHHPIDENIAMTKQVVDYAHAKGVSVEAEIGTVGGDEDGVTGGIN---YADPQ 158
Cdd:COG0191   78 LHLDHGASFELIKRAIDAGFTSVMIDGSHLPFEENIAITKEVVEYAHAAGVSVEAELGVVGGEEDGVDVDDAealYTDPE 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968 159 ECLRVVKEANIDALAAALGSVHGPYHGEPVLGFDEMKEISELTGAPLVLHGGSGIPEHQIKKAIELGHSKINVNTECQIV 238
Cdd:COG0191  158 EAAEFVEETGVDALAVAIGTVHGVYKGEPKLDFDRLKEIREAVPVPLVLHGGSGVPDEEIREAIKLGVAKINIDTDLRLA 237

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 675333968 239 WTAAVREKLATDDKVYDPRKVIGPGVDAIIKTVTEKIQEFGSNGKA 284
Cdd:COG0191  238 FTAAVREYLAENPDKYDPRKYLKPAREAMKEVVKEKIRLFGSAGKA 283
TBP_aldolase_IIB cd00947
Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase ...
 6-282 8.07e-145

Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1,6-bisphosphate. There is an absolute requirement for a divalent metal ion, usually zinc, and in addition the enzymes are activated by monovalent cations such as Na+. The type A and type B Class II FBPA's differ in the presence and absence of distinct indels in the sequence that result in differing loop lengths in the structures.


Pssm-ID: 238477  Cd Length: 276  Bit Score: 407.30  E-value: 8.07e-145
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968   6 MTDMLKKALAGKYAVGQFNINNLEWTQAILKAAEAEKAPVILGVSEGAAKYMGgFKTVVKMTEGLVEDLkiTVPVAIHLD 85
Cdd:cd00947    1 TKELLKKAREGGYAVGAFNINNLETLKAILEAAEETRSPVILQISEGAIKYAG-LELLVAMVKAAAERA--SVPVALHLD 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968  86 HGSSFDSCKAAIDAGFSSVMIDGSHHPIDENIAMTKQVVDYAHAKGVSVEAEIGTVGGDEDGVTGG-INYADPQECLRVV 164
Cdd:cd00947   78 HGSSFELIKRAIRAGFSSVMIDGSHLPFEENVAKTKEVVELAHAYGVSVEAELGRIGGEEDGVVGDeGLLTDPEEAEEFV 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968 165 KEANIDALAAALGSVHGPYHG-EPVLGFDEMKEISELTGAPLVLHGGSGIPEHQIKKAIELGHSKINVNTECQIVWTAAV 243
Cdd:cd00947  158 EETGVDALAVAIGTSHGAYKGgEPKLDFDRLKEIAERVNVPLVLHGGSGIPDEQIRKAIKLGVCKININTDLRLAFTAAL 237

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 675333968 244 REKLATDDKVYDPRKVIGPGVDAIIKTVTEKIQEFGSNG 282
Cdd:cd00947  238 REYLAENPKEFDPRKYLAPAIEAVKEVVKHKMELFGSAG 276
F_bP_aldolase pfam01116
Fructose-bisphosphate aldolase class-II;
4-283 2.15e-141

Fructose-bisphosphate aldolase class-II;


Pssm-ID: 460071  Cd Length: 276  Bit Score: 398.71  E-value: 2.15e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968    4 VNMTDMLKKALAGKYAVGQFNINNLEWTQAILKAAEAEKAPVILGVSEGAA-KYMGGFKTVVKMTEGLVEDLKitVPVAI 82
Cdd:pfam01116   1 VNLKELLKKAKEGGYAVPAFNVNNLETVQAILEAAEEAKSPVILQVSPGAAaKYAGGAEALAALVRAAAEAAG--VPVAL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968   83 HLDHGSSFDSCKAAIDAGFSSVMIDGSHHPIDENIAMTKQVVDYAHAKGVSVEAEIGTVGGDEDGVTGGIN-YADPQECL 161
Cdd:pfam01116  79 HLDHGASFELIKEAIEAGFTSVMIDGSHLPFEENIAITKEVVEYAHARGVSVEAELGRIGGEEDGVVVDEKlYTDPEEAA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968  162 RVVKEANIDALAAALGSVHGPYHGEPVLGFDEMKEISELTGAPLVLHGGSGIPEHQIKKAIELGHSKINVNTECQIVWTA 241
Cdd:pfam01116 159 EFVEATGVDALAVAIGNVHGVYKPGPKLDFDRLKEIQEAVPVPLVLHGGSGVPDEDIRKAIKLGVCKINIDTDLQLAFTA 238

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 675333968  242 AVREKlatdDKVYDPRKVIGPGVDAIIKTVTEKIQEFGSNGK 283
Cdd:pfam01116 239 AVREY----PPNKDPRKYLRPAEEAMKEVVKEKIRLFGSAGK 276
 
Name Accession Description Interval E-value
PRK07709 PRK07709
fructose-bisphosphate aldolase; Provisional
 1-284 3.67e-160

fructose-bisphosphate aldolase; Provisional


Pssm-ID: 169068  Cd Length: 285  Bit Score: 446.81  E-value: 3.67e-160
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968   1 MPIVNMTDMLKKALAGKYAVGQFNINNLEWTQAILKAAEAEKAPVILGVSEGAAKYMGGFKTVVKMTEGLVEDLKITVPV 80
Cdd:PRK07709   1 MPLVSMKEMLNKALEGKYAVGQFNMNNLEWTQAILAAAEEEKSPVILGVSEGAARHMTGFKTVVAMVKALIEEMNITVPV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968  81 AIHLDHGSSFDSCKAAIDAGFSSVMIDGSHHPIDENIAMTKQVVDYAHAKGVSVEAEIGTVGGDEDGVTG-GINYADPQE 159
Cdd:PRK07709  81 AIHLDHGSSFEKCKEAIDAGFTSVMIDASHHPFEENVETTKKVVEYAHARNVSVEAELGTVGGQEDDVIAeGVIYADPAE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968 160 CLRVVKEANIDALAAALGSVHGPYHGEPVLGFDEMKEISELTGAPLVLHGGSGIPEHQIKKAIELGHSKINVNTECQIVW 239
Cdd:PRK07709 161 CKHLVEATGIDCLAPALGSVHGPYKGEPNLGFAEMEQVRDFTGVPLVLHGGTGIPTADIEKAISLGTSKINVNTENQIEF 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 675333968 240 TAAVREKLATDDKVYDPRKVIGPGVDAIIKTVTEKIQEFGSNGKA 284
Cdd:PRK07709 241 TKAVREVLNKDQEVYDPRKFIGPGRDAIKATVIGKIREFGSNGKA 285
fruc_bis_ald_ TIGR01859
fructose-1,6-bisphosphate aldolase, class II, various bacterial and amitochondriate protist; ...
 3-284 3.78e-155

fructose-1,6-bisphosphate aldolase, class II, various bacterial and amitochondriate protist; This model represents of one of several subtypes of the class II fructose-1,6-bisphosphate aldolase, an enzyme of glycolysis. The subtypes are split into several models to allow separation of a family of tagatose bisphosphate aldolases. This form is found in Gram-positive bacteria, a variety of Gram-negative, and in amitochondriate protists. The class II enzymes share homology with tagatose bisphosphate aldolase but not with class I aldolase. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 130918  Cd Length: 282  Bit Score: 433.71  E-value: 3.78e-155
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968    3 IVNMTDMLKKALAGKYAVGQFNINNLEWTQAILKAAEAEKAPVILGVSEGAAKYMGGFKTVVKMTEGLVEDLKItVPVAI 82
Cdd:TIGR01859   1 LVNGKEILQKAKKEGYAVGAFNFNNLEWTQAILEAAEEENSPVIIQVSEGAIKYMGGYKMAVAMVKTLIERMSI-VPVAL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968   83 HLDHGSSFDSCKAAIDAGFSSVMIDGSHHPIDENIAMTKQVVDYAHAKGVSVEAEIGTVGGDEDGVTG-GINYADPQECL 161
Cdd:TIGR01859  80 HLDHGSSYESCIKAIKAGFSSVMIDGSHLPFEENLALTKKVVEIAHAKGVSVEAELGTLGGIEDGVDEkEAELADPDEAE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968  162 RVVKEANIDALAAALGSVHGPYHGEPVLGFDEMKEISELTGAPLVLHGGSGIPEHQIKKAIELGHSKINVNTECQIVWTA 241
Cdd:TIGR01859 160 QFVKETGVDYLAAAIGTSHGKYKGEPGLDFERLKEIKELTNIPLVLHGASGIPEEQIKKAIKLGIAKINIDTDCRIAFTA 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 675333968  242 AVREKLATDDKVYDPRKVIGPGVDAIIKTVTEKIQEFGSNGKA 284
Cdd:TIGR01859 240 AIRKVLTEKKDEYDPRKILGPAREAIKETVKEKMRLFGSAGKA 282
PRK08610 PRK08610
fructose-bisphosphate aldolase; Reviewed
 1-284 3.34e-154

fructose-bisphosphate aldolase; Reviewed


Pssm-ID: 181501  Cd Length: 286  Bit Score: 431.72  E-value: 3.34e-154
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968   1 MPIVNMTDMLKKALAGKYAVGQFNINNLEWTQAILKAAEAEKAPVILGVSEGAAKYMGGFKTVVKMTEGLVEDLKITVPV 80
Cdd:PRK08610   1 MPLVSMKEMLIDAKENGYAVGQYNLNNLEFTQAILEASQEENAPVILGVSEGAARYMSGFYTVVKMVEGLMHDLNITIPV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968  81 AIHLDHGSSFDSCKAAIDAGFSSVMIDGSHHPIDENIAMTKQVVDYAHAKGVSVEAEIGTVGGDEDGVTG-GINYADPQE 159
Cdd:PRK08610  81 AIHLDHGSSFEKCKEAIDAGFTSVMIDASHSPFEENVATTKKVVEYAHEKGVSVEAELGTVGGQEDDVVAdGIIYADPKE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968 160 CLRVVKEANIDALAAALGSVHGPYHGEPVLGFDEMKEISELTGAPLVLHGGSGIPEHQIKKAIELGHSKINVNTECQIVW 239
Cdd:PRK08610 161 CQELVEKTGIDALAPALGSVHGPYKGEPKLGFKEMEEIGLSTGLPLVLHGGTGIPTKDIQKAIPFGTAKINVNTENQIAS 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 675333968 240 TAAVREKLATDDKVYDPRKVIGPGVDAIIKTVTEKIQEFGSNGKA 284
Cdd:PRK08610 241 AKAVRDVLNNDKEVYDPRKYLGPAREAIKETVKGKIKEFGTSNRA 285
Fba COG0191
Fructose/tagatose bisphosphate aldolase [Carbohydrate transport and metabolism]; Fructose ...
 2-284 9.68e-152

Fructose/tagatose bisphosphate aldolase [Carbohydrate transport and metabolism]; Fructose/tagatose bisphosphate aldolase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439961  Cd Length: 283  Bit Score: 425.27  E-value: 9.68e-152
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968   2 PIVNMTDMLKKALAGKYAVGQFNINNLEWTQAILKAAEAEKAPVILGVSEGAAKYMGgFKTVVKMTEGLVEdlKITVPVA 81
Cdd:COG0191    1 MLVSLKELLDKAKEGGYAVPAFNVNNLETLQAILEAAEELNSPVILQVSEGAAKYAG-LEYLAAMVRAAAE--EASVPVA 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968  82 IHLDHGSSFDSCKAAIDAGFSSVMIDGSHHPIDENIAMTKQVVDYAHAKGVSVEAEIGTVGGDEDGVTGGIN---YADPQ 158
Cdd:COG0191   78 LHLDHGASFELIKRAIDAGFTSVMIDGSHLPFEENIAITKEVVEYAHAAGVSVEAELGVVGGEEDGVDVDDAealYTDPE 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968 159 ECLRVVKEANIDALAAALGSVHGPYHGEPVLGFDEMKEISELTGAPLVLHGGSGIPEHQIKKAIELGHSKINVNTECQIV 238
Cdd:COG0191  158 EAAEFVEETGVDALAVAIGTVHGVYKGEPKLDFDRLKEIREAVPVPLVLHGGSGVPDEEIREAIKLGVAKINIDTDLRLA 237

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 675333968 239 WTAAVREKLATDDKVYDPRKVIGPGVDAIIKTVTEKIQEFGSNGKA 284
Cdd:COG0191  238 FTAAVREYLAENPDKYDPRKYLKPAREAMKEVVKEKIRLFGSAGKA 283
TBP_aldolase_IIB cd00947
Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase ...
 6-282 8.07e-145

Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1,6-bisphosphate. There is an absolute requirement for a divalent metal ion, usually zinc, and in addition the enzymes are activated by monovalent cations such as Na+. The type A and type B Class II FBPA's differ in the presence and absence of distinct indels in the sequence that result in differing loop lengths in the structures.


Pssm-ID: 238477  Cd Length: 276  Bit Score: 407.30  E-value: 8.07e-145
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968   6 MTDMLKKALAGKYAVGQFNINNLEWTQAILKAAEAEKAPVILGVSEGAAKYMGgFKTVVKMTEGLVEDLkiTVPVAIHLD 85
Cdd:cd00947    1 TKELLKKAREGGYAVGAFNINNLETLKAILEAAEETRSPVILQISEGAIKYAG-LELLVAMVKAAAERA--SVPVALHLD 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968  86 HGSSFDSCKAAIDAGFSSVMIDGSHHPIDENIAMTKQVVDYAHAKGVSVEAEIGTVGGDEDGVTGG-INYADPQECLRVV 164
Cdd:cd00947   78 HGSSFELIKRAIRAGFSSVMIDGSHLPFEENVAKTKEVVELAHAYGVSVEAELGRIGGEEDGVVGDeGLLTDPEEAEEFV 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968 165 KEANIDALAAALGSVHGPYHG-EPVLGFDEMKEISELTGAPLVLHGGSGIPEHQIKKAIELGHSKINVNTECQIVWTAAV 243
Cdd:cd00947  158 EETGVDALAVAIGTSHGAYKGgEPKLDFDRLKEIAERVNVPLVLHGGSGIPDEQIRKAIKLGVCKININTDLRLAFTAAL 237

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 675333968 244 REKLATDDKVYDPRKVIGPGVDAIIKTVTEKIQEFGSNG 282
Cdd:cd00947  238 REYLAENPKEFDPRKYLAPAIEAVKEVVKHKMELFGSAG 276
F_bP_aldolase pfam01116
Fructose-bisphosphate aldolase class-II;
4-283 2.15e-141

Fructose-bisphosphate aldolase class-II;


Pssm-ID: 460071  Cd Length: 276  Bit Score: 398.71  E-value: 2.15e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968    4 VNMTDMLKKALAGKYAVGQFNINNLEWTQAILKAAEAEKAPVILGVSEGAA-KYMGGFKTVVKMTEGLVEDLKitVPVAI 82
Cdd:pfam01116   1 VNLKELLKKAKEGGYAVPAFNVNNLETVQAILEAAEEAKSPVILQVSPGAAaKYAGGAEALAALVRAAAEAAG--VPVAL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968   83 HLDHGSSFDSCKAAIDAGFSSVMIDGSHHPIDENIAMTKQVVDYAHAKGVSVEAEIGTVGGDEDGVTGGIN-YADPQECL 161
Cdd:pfam01116  79 HLDHGASFELIKEAIEAGFTSVMIDGSHLPFEENIAITKEVVEYAHARGVSVEAELGRIGGEEDGVVVDEKlYTDPEEAA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968  162 RVVKEANIDALAAALGSVHGPYHGEPVLGFDEMKEISELTGAPLVLHGGSGIPEHQIKKAIELGHSKINVNTECQIVWTA 241
Cdd:pfam01116 159 EFVEATGVDALAVAIGNVHGVYKPGPKLDFDRLKEIQEAVPVPLVLHGGSGVPDEDIRKAIKLGVCKINIDTDLQLAFTA 238

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 675333968  242 AVREKlatdDKVYDPRKVIGPGVDAIIKTVTEKIQEFGSNGK 283
Cdd:pfam01116 239 AVREY----PPNKDPRKYLRPAEEAMKEVVKEKIRLFGSAGK 276
cbbA TIGR00167
ketose-bisphosphate aldolase; This model is under revision. Proteins found by this model ...
 1-284 2.15e-135

ketose-bisphosphate aldolase; This model is under revision. Proteins found by this model include fructose-bisphosphate and tagatose-bisphosphate aldolase. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 272938  Cd Length: 288  Bit Score: 383.98  E-value: 2.15e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968    1 MPIVNMTDMLKKALAGKYAVGQFNINNLEWTQAILKAAEAEKAPVILGVSEGAAKYMGGFKTVVKMTEGLVEDLKITVPV 80
Cdd:TIGR00167   1 MMLVDVKELLQDAKEEGYAIPAFNINNLETINAVLEAAAEEKSPVIIQFSNGAAKYIAGLGAISAMVKAMSEAYPYGVPV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968   81 AIHLDHGSSFDSCKAAIDAGFSSVMIDGSHHPIDENIAMTKQVVDYAHAKGVSVEAEIGTVGGDEDGVT---GGINYADP 157
Cdd:TIGR00167  81 ALHLDHGASEEDCAQAVKAGFSSVMIDGSHEPFEENIELTKKVVERAHKMGVSVEAELGTLGGEEDGVSvadESALYTDP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968  158 QECLRVVKEANIDALAAALGSVHGPYHGEPV-LGFDEMKEISELTGAPLVLHGGSGIPEHQIKKAIELGHSKINVNTECQ 236
Cdd:TIGR00167 161 EEAKEFVKLTGVDSLAAAIGNVHGVYKGEPKgLDFERLEEIQKYVNLPLVLHGGSGIPDEEIKKAISLGVVKVNIDTELQ 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 675333968  237 IVWTAAVREKLATDDKVYDPRKVIGPGVDAIIKTVTEKIQEFGSNGKA 284
Cdd:TIGR00167 241 IAFAAAVRNYYAENKDYYDPRVWLRPGEKAMKEVVLEKIKLFGSANKA 288
PRK12857 PRK12857
class II fructose-1,6-bisphosphate aldolase;
1-284 7.19e-118

class II fructose-1,6-bisphosphate aldolase;


Pssm-ID: 237235  Cd Length: 284  Bit Score: 339.39  E-value: 7.19e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968   1 MPIVNMTDMLKKALAGKYAVGQFNINNLEWTQAILKAAEAEKAPVILGVSEGAAKYmGGFKTVVKMTEGLVEdlKITVPV 80
Cdd:PRK12857   1 MMLVTVAELLKKAEKGGYAVGAFNCNNMEIVQAIVAAAEAEKSPVIIQASQGAIKY-AGIEYISAMVRTAAE--KASVPV 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968  81 AIHLDHGSSFDSCKAAIDAGFSSVMIDGSHHPIDENIAMTKQVVDYAHAKGVSVEAEIGTVGGDEDGVTGGINYA---DP 157
Cdd:PRK12857  78 ALHLDHGTDFEQVMKCIRNGFTSVMIDGSKLPLEENIALTKKVVEIAHAVGVSVEAELGKIGGTEDDITVDEREAamtDP 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968 158 QECLRVVKEANIDALAAALGSVHGPYHGEPVLGFDEMKEISELTGAPLVLHGGSGIPEHQIKKAIELGHSKINVNTECQI 237
Cdd:PRK12857 158 EEARRFVEETGVDALAIAIGTAHGPYKGEPKLDFDRLAKIKELVNIPIVLHGSSGVPDEAIRKAISLGVRKVNIDTNIRE 237

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 675333968 238 VWTAAVREKLATDDKVYDPRKVIGPGVDAIIKTVTEKIQEFGSNGKA 284
Cdd:PRK12857 238 AFVARLREVLEKNPDEIDPRKILGPAREAAKEVIREKIRLFGSAGKA 284
PRK07315 PRK07315
fructose-bisphosphate aldolase; Provisional
 1-284 1.75e-101

fructose-bisphosphate aldolase; Provisional


Pssm-ID: 180926  Cd Length: 293  Bit Score: 298.34  E-value: 1.75e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968   1 MPIVNMTDMLKKALAGKYAVGQFNINNLEWTQAILKAAEAEKAPVILGVSEGAAKYMGGFKTVVKMTEGLVEDLKITVPV 80
Cdd:PRK07315   1 MAIVSAEKFVQAARDNGYAVGGFNTNNLEWTQAILRAAEAKKAPVLIQTSMGAAKYMGGYKVCKNLIENLVESMGITVPV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968  81 AIHLDHGsSFDSCKAAIDAGFSSVMIDGSHHPIDENIAMTKQVVDYAHAKGVSVEAEIGTVGGDEDGVTGGINYADPQEC 160
Cdd:PRK07315  81 AIHLDHG-HYEDALECIEVGYTSIMFDGSHLPVEENLKLAKEVVEKAHAKGISVEAEVGTIGGEEDGIIGKGELAPIEDA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968 161 LRVVkEANIDALAAALGSVHGPYHGE-PVLGFDEMKEISE-LTGAPLVLHGGSGIPEHQIKKAIELGHSKINVNTECQIV 238
Cdd:PRK07315 160 KAMV-ETGIDFLAAGIGNIHGPYPENwEGLDLDHLEKLTEaVPGFPIVLHGGSGIPDDQIQEAIKLGVAKVNVNTECQIA 238

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 675333968 239 WTAAVREKLA---------TDDKVYDPRKVIGPGVDAIIKTVTEKIQEFGSNGKA 284
Cdd:PRK07315 239 FANATRKFARdyeaneaeyDKKKLFDPRKFLAPGVKAIQASVEERIDVFGSANKA 293
gatY PRK12737
tagatose-bisphosphate aldolase subunit GatY;
1-284 1.23e-95

tagatose-bisphosphate aldolase subunit GatY;


Pssm-ID: 183710  Cd Length: 284  Bit Score: 283.12  E-value: 1.23e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968   1 MPIVNMTDMLKKALAGKYAVGQFNINNLEWTQAILKAAEAEKAPVILGVSEGAAKYmGGFKTVVKMTEGLVEdlKITVPV 80
Cdd:PRK12737   1 MYIISTKNMLKKAQAEGYAVPAFNIHNLETLQVVVETAAELRSPVILAGTPGTFSY-AGTDYIVAIAEVAAR--KYNIPL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968  81 AIHLDHGSSFDSCKAAIDAGFSSVMIDGSHHPIDENIAMTKQVVDYAHAKGVSVEAEIGTVGGDEDGVTGGIN---YADP 157
Cdd:PRK12737  78 ALHLDHHEDLDDIKKKVRAGIRSVMIDGSHLSFEENIAIVKEVVEFCHRYDASVEAELGRLGGQEDDLVVDEKdamYTNP 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968 158 QECLRVVKEANIDALAAALGSVHGPYHGEPVLGFDEMKEISELTGAPLVLHGGSGIPEHQIKKAIELGHSKINVNTECQI 237
Cdd:PRK12737 158 DAAAEFVERTGIDSLAVAIGTAHGLYKGEPKLDFERLAEIREKVSIPLVLHGASGVPDEDVKKAISLGICKVNVATELKI 237

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 675333968 238 VWTAAVREKLATDDKVYDPRKVIGPGVDAIIKTVTEKIQEFGSNGKA 284
Cdd:PRK12737 238 AFSDAVKKYFYENPKANDPRKYMTPGKAAMKEVVREKIKVCGSEGKL 284
gatY PRK09195
tagatose-bisphosphate aldolase; Reviewed
 1-284 3.24e-92

tagatose-bisphosphate aldolase; Reviewed


Pssm-ID: 181690  Cd Length: 284  Bit Score: 274.31  E-value: 3.24e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968   1 MPIVNMTDMLKKALAGKYAVGQFNINNLEWTQAILKAAEAEKAPVILGVSEGAAKYMGgFKTVVKMTEGLVEdlKITVPV 80
Cdd:PRK09195   1 MYLVSTKQMLNNAQRGGYAVPAFNIHNLETMQVVVETAAELHSPVIIAGTPGTFSYAG-TEYLLAIVSAAAK--QYHHPL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968  81 AIHLDHGSSFDSCKAAIDAGFSSVMIDGSHHPIDENIAMTKQVVDYAHAKGVSVEAEIGTVGGDEDGVTGGIN---YADP 157
Cdd:PRK09195  78 ALHLDHHEKFDDIAQKVRSGVRSVMIDGSHLPFAQNISLVKEVVDFCHRFDVSVEAELGRLGGQEDDLQVDEAdalYTDP 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968 158 QECLRVVKEANIDALAAALGSVHGPYHGEPVLGFDEMKEISELTGAPLVLHGGSGIPEHQIKKAIELGHSKINVNTECQI 237
Cdd:PRK09195 158 AQAREFVEATGIDSLAVAIGTAHGMYKGEPKLDFDRLENIRQWVNIPLVLHGASGLPTKDIQQTIKLGICKVNVATELKI 237

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 675333968 238 VWTAAVREKLATDDKVYDPRKVIGPGVDAIIKTVTEKIQEFGSNGKA 284
Cdd:PRK09195 238 AFSQALKNYLTEHPEANDPRHYLQPAKSAMKDVVSKVIADCGCEGKA 284
PRK07084 PRK07084
class II fructose-1,6-bisphosphate aldolase;
3-284 3.68e-87

class II fructose-1,6-bisphosphate aldolase;


Pssm-ID: 180829  Cd Length: 321  Bit Score: 262.74  E-value: 3.68e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968   3 IVNMTDMLKKALAGKYAVGQFNINNLEWTQAILKAAEAEKAPVILGVSEGAAKYMGGfkTVVK-MTEGLVE---DLKITV 78
Cdd:PRK07084   9 LVNTREMFAKAVKGGYAIPAYNFNNMEQLQAIIQACVETKSPVILQVSKGARKYANA--TLLRyMAQGAVEyakELGCPI 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968  79 PVAIHLDHGSSFDSCKAAIDAGFSSVMIDGSHHPIDENIAMTKQVVDYAHAKGVSVEAEIGTVGGDEDGVTGGIN-YADP 157
Cdd:PRK07084  87 PIVLHLDHGDSFELCKDCIDSGFSSVMIDGSHLPYEENVALTKKVVEYAHQFDVTVEGELGVLAGVEDEVSAEHHtYTQP 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968 158 QECLRVVKEANIDALAAALGSVHGPYH---GE--PVLGFDEMKEISE-LTGAPLVLHGGS-------------------- 211
Cdd:PRK07084 167 EEVEDFVKKTGVDSLAISIGTSHGAYKfkpGQcpPPLRFDILEEIEKrIPGFPIVLHGSSsvpqeyvktineyggklkda 246

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 675333968 212 -GIPEHQIKKAIELGHSKINVNTECQIVWTAAVREKLATDDKVYDPRKVIGPGVDAIIKTVTEKIQE-FGSNGKA 284
Cdd:PRK07084 247 iGIPEEQLRKAAKSAVCKINIDSDGRLAMTAAIRKVFDEKPEEFDPRKYLGPARDELKKLYKHKIINvLGSNGKA 321
tag_bisphos_ald TIGR01858
class II aldolase, tagatose bisphosphate family; This model describes tagatose-1, ...
 3-284 6.53e-81

class II aldolase, tagatose bisphosphate family; This model describes tagatose-1,6-bisphosphate aldolases, and perhaps other closely related class II aldolases. This tetrameric, Zn2+-dependent enzyme is related to the class II fructose bisphosphate aldolase; fructose 1,6-bisphosphate and tagatose 1,6 bisphosphate differ only in chirality at C4.


Pssm-ID: 130917  Cd Length: 282  Bit Score: 245.54  E-value: 6.53e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968    3 IVNMTDMLKKALAGKYAVGQFNINNLEWTQAILKAAEAEKAPVILGVSEGAAKYMGgFKTVVKMTEGLVEdlKITVPVAI 82
Cdd:TIGR01858   1 IVSTKYMLQDAQAGGYAVPAFNIHNLETIQAVVETAAEMRSPVILAGTPGTFKHAG-TEYIVALCSAAST--TYNMPLAL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968   83 HLDHGSSFDSCKAAIDAGFSSVMIDGSHHPIDENIAMTKQVVDYAHAKGVSVEAEIGTVGGDEDGVTGGIN---YADPQE 159
Cdd:TIGR01858  78 HLDHHESLDDIRQKVHAGVRSAMIDGSHFPFAQNVKLVKEVVDFCHRQDCSVEAELGRLGGVEDDLSVDEEdalYTDPQE 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968  160 CLRVVKEANIDALAAALGSVHGPYHGEPVLGFDEMKEISELTGAPLVLHGGSGIPEHQIKKAIELGHSKINVNTECQIVW 239
Cdd:TIGR01858 158 AKEFVEATGVDSLAVAIGTAHGLYKKTPKLDFDRLAEIREVVDVPLVLHGASDVPDEDVRRTIELGICKVNVATELKIAF 237

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 675333968  240 TAAVREKLATDDKVYDPRKVIGPGVDAIIKTVTEKIQEFGSNGKA 284
Cdd:TIGR01858 238 SGAVKAYFAENPQANDPRYYMRPGKDAMKKVVRNKINVCGSAGRA 282
PRK05835 PRK05835
class II fructose-1,6-bisphosphate aldolase;
3-283 4.01e-79

class II fructose-1,6-bisphosphate aldolase;


Pssm-ID: 180280 [Multi-domain]  Cd Length: 307  Bit Score: 241.80  E-value: 4.01e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968   3 IVNMTDMLKKALAGKYAVGQFNINNLEWTQAILKAAEAEKAPVILGVSEGAAKYMGgfktvVKMTEGLVEDLKIT---VP 79
Cdd:PRK05835   2 LVKGNEILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYMG-----IDMAVGMVKIMCERyphIP 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968  80 VAIHLDHGSSFDSCKAAIDAGFSSVMIDGSHHPIDENIAMTKQVVDYAHAKGVSVEAEIGTVGGDEDGVTGGINYA---D 156
Cdd:PRK05835  77 VALHLDHGTTFESCEKAVKAGFTSVMIDASHHAFEENLELTSKVVKMAHNAGVSVEAELGRLMGIEDNISVDEKDAvlvN 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968 157 PQECLRVVKEANIDALAAALGSVHGP--YHGEPVLGFDEMKEISELTGAPLVLHGGSGIPEHQ----------------- 217
Cdd:PRK05835 157 PKEAEQFVKESQVDYLAPAIGTSHGAfkFKGEPKLDFERLQEVKRLTNIPLVLHGASAIPDDVrksyldaggdlkgskgv 236

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 675333968 218 ----IKKAIELGHSKINVNTECQIVWTAAVReKLATDDKV-YDPRKVIGPGVDAIIKTVTEKIQEFGSNGK 283
Cdd:PRK05835 237 pfefLQESVKGGINKVNTDTDLRIAFIAEVR-KVANEDKSqFDLRKFFSPAQLALKNVVKERMKLLGSANK 306
PRK06806 PRK06806
class II aldolase;
1-284 1.76e-78

class II aldolase;


Pssm-ID: 180705  Cd Length: 281  Bit Score: 239.27  E-value: 1.76e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968   1 MPIVNMTDMLKKALAGKYAVGQFNINNLEWTQAILKAAEAEKAPVILGVSEGAAKY-----MGgfKTVVKMTEglvedlK 75
Cdd:PRK06806   1 MPLVQMKELLKKANQENYGVGAFSVANMEMVMGAIKAAEELNSPIILQIAEVRLNHsplhlIG--PLMVAAAK------Q 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968  76 ITVPVAIHLDHGSSFDSCKAAIDAGFSSVMIDGSHHPIDENIAMTKQVVDYAHAKGVSVEAEIGTVGGDEDGVTG-GINY 154
Cdd:PRK06806  73 AKVPVAVHFDHGMTFEKIKEALEIGFTSVMFDGSHLPLEENIQKTKEIVELAKQYGATVEAEIGRVGGSEDGSEDiEMLL 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968 155 ADPQECLRVVKEANIDALAAALGSVHGPYHGEPVLGFDEMKEISELTGAPLVLHGGSGIPEHQIKKAIELGHSKINVNTE 234
Cdd:PRK06806 153 TSTTEAKRFAEETDVDALAVAIGNAHGMYNGDPNLRFDRLQEINDVVHIPLVLHGGSGISPEDFKKCIQHGIRKINVATA 232

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 675333968 235 CQIVWTAAVREKLATDDKvYDPRKVIGPGVDAIIKTVTEKIQEFGSNGKA 284
Cdd:PRK06806 233 TFNSVITAVNNLVLNTPY-SDYFTYHQDVIKAAYENVKKHMQIFGSENKA 281
PRK08185 PRK08185
hypothetical protein; Provisional
 6-284 1.12e-77

hypothetical protein; Provisional


Pssm-ID: 181275  Cd Length: 283  Bit Score: 237.32  E-value: 1.12e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968   6 MTDMLKKALAGKYAVGQFNINNLEWTQAILKAAEAEKAPVILGVSEGAAKYMGG--FKTVVKMTeglvedLKITVPVAIH 83
Cdd:PRK08185   1 MKELLKVAKEHQFAVGAFNVADSCFLRAVVEEAEANNAPAIIAIHPNELDFLGDnfFAYVRERA------KRSPVPFVIH 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968  84 LDHGSSFDSCKAAIDAGFSSVMIDGSHHPIDENIAMTKQVVDYAHAKGVSVEAEIGTVGGDEDGVTGGIN---YADPQEC 160
Cdd:PRK08185  75 LDHGATIEDVMRAIRCGFTSVMIDGSLLPYEENVALTKEVVELAHKVGVSVEGELGTIGNTGTSIEGGVSeiiYTDPEQA 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968 161 LRVVKEANIDALAAALGSVHG--PYHGEPVLGFDEMKEISELTGAPLVLHGGSGIPEHQIKKAIELGHSKINVNTECQIV 238
Cdd:PRK08185 155 EDFVSRTGVDTLAVAIGTAHGiyPKDKKPELQMDLLKEINERVDIPLVLHGGSANPDAEIAESVQLGVGKINISSDMKYA 234

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 675333968 239 WTAAVREKLATDDKVYDPRKVIGPGVDAIIKTVTEKIQEFGSNGKA 284
Cdd:PRK08185 235 FFKKVREILSDNPSLYEPNQIYPSAIEAAKEVVRHKMDLFNSTGKA 280
PRK06801 PRK06801
ketose 1,6-bisphosphate aldolase;
1-284 7.27e-74

ketose 1,6-bisphosphate aldolase;


Pssm-ID: 180701  Cd Length: 286  Bit Score: 227.71  E-value: 7.27e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968   1 MPIVNMTDMLKKALAGKYAVGQFNINNLEWTQAILKAAEAEKAPVILGVSEGAAKYMGgfktvvkmTEGLVEDLKI---- 76
Cdd:PRK06801   1 MALISLANGLAHARKHGYALGAFNVLDSHFLRALFAAAKQERSPFIINIAEVHFKYIS--------LESLVEAVKFeaar 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968  77 -TVPVAIHLDHGSSFDSCKAAIDAGFSSVMIDGSHHPIDENIAMTKQVVDYAHAKGVSVEAEIGTVGGDEDGVTGGI--- 152
Cdd:PRK06801  73 hDIPVVLNLDHGLHFEAVVRALRLGFSSVMFDGSTLEYEENVRQTREVVKMCHAVGVSVEAELGAVGGDEGGALYGEads 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968 153 -NYADPQECLRVVKEANIDALAAALGSVHGPYHGEPVLGFDEMKEISELTGAPLVLHGGSGIPEHQIKKAIELGHSKINV 231
Cdd:PRK06801 153 aKFTDPQLARDFVDRTGIDALAVAIGNAHGKYKGEPKLDFARLAAIHQQTGLPLVLHGGSGISDADFRRAIELGIHKINF 232

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 675333968 232 NTECQIVWTAAVREKLATDDKVYDPRKVIGPGVD-AIIKTVTEKIQEFGSNGKA 284
Cdd:PRK06801 233 YTGMSQAALAAVEQRMTHRHAIYDEFAELLLGIEeAISDTVAQQMRIFGSAGQA 286
kbaY PRK12738
tagatose-bisphosphate aldolase subunit KbaY;
1-283 1.22e-71

tagatose-bisphosphate aldolase subunit KbaY;


Pssm-ID: 183711  Cd Length: 286  Bit Score: 222.22  E-value: 1.22e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968   1 MPIVNMTDMLKKALAGKYAVGQFNINNLEWTQAILKAAEAEKAPVILGVSEGAAKYMGgFKTVVKMTEGLVEDLKItvPV 80
Cdd:PRK12738   1 MSIISTKYLLQDAQANGYAVPAFNIHNAETIQAILEVCSEMRSPVILAGTPGTFKHIA-LEEIYALCSAYSTTYNM--PL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968  81 AIHLDHGSSFDSCKAAIDAGFSSVMIDGSHHPIDENIAMTKQVVDYAHAKGVSVEAEIGTVGGDEDGVTGGINYA---DP 157
Cdd:PRK12738  78 ALHLDHHESLDDIRRKVHAGVRSAMIDGSHFPFAENVKLVKSVVDFCHSQDCSVEAELGRLGGVEDDMSVDAESAfltDP 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968 158 QECLRVVKEANIDALAAALGSVHGPYHGEPVLGFDEMKEISELTGAPLVLHGGSGIPEHQIKKAIELGHSKINVNTECQI 237
Cdd:PRK12738 158 QEAKRFVELTGVDSLAVAIGTAHGLYSKTPKIDFQRLAEIREVVDVPLVLHGASDVPDEFVRRTIELGVTKVNVATELKI 237

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 675333968 238 VWTAAVREKLATDDKVYDPRKVIGPGVDAIIKTVTEKIQEFGSNGK 283
Cdd:PRK12738 238 AFAGAVKAWFAENPQGNDPRYYMRVGMDAMKEVVRNKINVCGSANR 283
gatY PRK07998
class II aldolase;
1-281 6.38e-70

class II aldolase;


Pssm-ID: 181192  Cd Length: 283  Bit Score: 217.71  E-value: 6.38e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968   1 MPIVNMTDMLKKALAGKYAVGQFNINNLEWTQAILKAAEAEKAPVILGVSEGAAKyMGGFKTVVKMTEGLVEdlKITVPV 80
Cdd:PRK07998   1 MPLVNGRILLDRIQEKHVLAGAFNTTNLETTISILNAIERSGLPNFIQIAPTNAQ-LSGYDYIYEIVKRHAD--KMDVPV 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968  81 AIHLDHGSSFDSCKAAIDAGFSSVMIDGSHHPIDENIAMTKQVVDYAHAKGVSVEAEIGTVGGDEDG-VTGGINYADPQE 159
Cdd:PRK07998  78 SLHLDHGKTFEDVKQAVRAGFTSVMIDGAALPFEENIAFTKEAVDFAKSYGVPVEAELGAILGKEDDhVSEADCKTEPEK 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968 160 CLRVVKEANIDALAAALGSVHGpYHGEPVLGFDEMKEISELTGAPLVLHGGSGIPEHQIKKAIELGHSKINVNTECQIVW 239
Cdd:PRK07998 158 VKDFVERTGCDMLAVSIGNVHG-LEDIPRIDIPLLKRIAEVSPVPLVIHGGSGIPPEILRSFVNYKVAKVNIASDLRKAF 236

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 675333968 240 TAAVREKLATDDKVYDPRKVIGPGVDAIIKTVTEKIQEFGSN 281
Cdd:PRK07998 237 ITTVGKAYVNNHNEANLARVMAKAKQAVEEDVYSKIKMMNSN 278
PRK09196 PRK09196
fructose-bisphosphate aldolase class II;
1-284 7.42e-70

fructose-bisphosphate aldolase class II;


Pssm-ID: 181691  Cd Length: 347  Bit Score: 219.44  E-value: 7.42e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968   1 MPIVNMTDMLKKALAGKYAVGQFNINNLEWTQAILKAAEAEKAPVILGVSEGAAKYMGGfKTVVKMTEGLVEDLKiTVPV 80
Cdd:PRK09196   1 MALISLRQLLDHAAEHGYGVPAFNVNNLEQVQAIMEAADETDSPVILQASAGARKYAGE-PFLRHLILAAVEEYP-HIPV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968  81 AIHLDHGSSFDSCKAAIDAGFSSVMIDGSHHP-------IDENIAMTKQVVDYAHAKGVSVEAEIGTVG-------GDED 146
Cdd:PRK09196  79 VMHQDHGNSPATCQRAIQLGFTSVMMDGSLKAdgktpasYEYNVDVTRKVVEMAHACGVSVEGELGCLGsletgmgGEED 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968 147 GV--TGGINYA----DPQECLRVVKEANIDALAAALGSVHGPYH------GEpVLGFDEMKEISE-LTGAPLVLHGGS-- 211
Cdd:PRK09196 159 GHgaEGKLSHDqlltDPEEAADFVKKTQVDALAIAIGTSHGAYKftrkptGD-VLAIDRIKEIHArLPNTHLVMHGSSsv 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968 212 -------------------GIPEHQIKKAIELGHSKINVNTECQIVWTAAVREKLATDDKVYDPRKVIGPGVDAIIKTVT 272
Cdd:PRK09196 238 pqelldiineyggdmpetyGVPVEEIQEGIKHGVRKVNIDTDLRLAMTGAIRRFLAENPSEFDPRKYLKPAMEAMKKICK 317

                        330
                 ....*....|..
gi 675333968 273 EKIQEFGSNGKA 284
Cdd:PRK09196 318 ARYEAFGTAGQA 329
PRK13399 PRK13399
fructose-bisphosphate aldolase class II;
1-284 1.90e-60

fructose-bisphosphate aldolase class II;


Pssm-ID: 184029  Cd Length: 347  Bit Score: 195.38  E-value: 1.90e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968   1 MPIVNMTDMLKKALAGKYAVGQFNINNLEWTQAILKAAEAEKAPVILGVSEGAAKYMGGfKTVVKMTEGLVEDLKiTVPV 80
Cdd:PRK13399   1 MALITLRQLLDHAAENGYGVPAFNVNNMEQILAIMEAAEATDSPVILQASRGARKYAGD-AMLRHMVLAAAEMYP-DIPI 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968  81 AIHLDHGSSFDSCKAAIDAGFSSVMIDGSHHP-------IDENIAMTKQVVDYAHAKGVSVEAEIGTVG-------GDED 146
Cdd:PRK13399  79 CLHQDHGNSPATCQSAIRSGFTSVMMDGSLLAdgktpasYDYNVDVTRRVTEMAHAVGVSVEGELGCLGsletgeaGEED 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968 147 GV--TGGINY----ADPQECLRVVKEANIDALAAALGSVHGPYH------GEpVLGFDEMKEI-SELTGAPLVLHGGS-- 211
Cdd:PRK13399 159 GVgaEGKLSHdqmlTDPDQAVDFVQRTGVDALAIAIGTSHGAYKftrkpdGD-ILAIDRIEEIhARLPNTHLVMHGSSsv 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968 212 -------------------GIPEHQIKKAIELGHSKINVNTECQIVWTAAVREKLATDDKVYDPRKVIGPGVDAIIKTVT 272
Cdd:PRK13399 238 pqelqeiinayggkmketyGVPVEEIQRGIKHGVRKVNIDTDIRLAMTGAIRKVLAEHPSEFDPRKALKPAMKAMTALCK 317

                        330
                 ....*....|..
gi 675333968 273 EKIQEFGSNGKA 284
Cdd:PRK13399 318 QRFEAFGTAGQA 329
PLN02858 PLN02858
fructose-bisphosphate aldolase
 8-284 3.30e-58

fructose-bisphosphate aldolase


Pssm-ID: 215463 [Multi-domain]  Cd Length: 1378  Bit Score: 200.85  E-value: 3.30e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968    8 DMLKKALAGKYAVGQFNINNLEWTQAILKAAEAEKAPVILGVSEGAAKyMGGFKTVVKMtegLVEDLKITVPVAIHLDHG 87
Cdd:PLN02858 1104 ELLLNAEKGGYAVGAFNVYNLEGIEAVVAAAEAEKSPAILQVHPGALK-QGGIPLVSCC---IAAAEQASVPITVHFDHG 1179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968   88 SSFDSCKAAIDAGFSSVMIDGSHHPIDENIAMTKQVVDYAHAKGVSVEAEIGTVGGDEDGVT---GGINYADPQECLRVV 164
Cdd:PLN02858 1180 TSKHELLEALELGFDSVMVDGSHLSFTENISYTKSISSLAHSKGLMVEAELGRLSGTEDGLTveeYEAKLTDVDQAKEFI 1259

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968  165 KEANIDALAAALGSVHGPYHGE-PVLGFDEMKEISELT---GAPLVLHGGSGIPEHQIKKAIELGHSKINVNTECQIVWT 240
Cdd:PLN02858 1260 DETGIDALAVCIGNVHGKYPASgPNLRLDLLKELRALSskkGVLLVLHGASGLPESLIKECIENGVRKFNVNTEVRTAYM 1339

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 675333968  241 aavrEKLATDDKVyDPRKVIGPGVDAIIKTVTEKIQEFGSNGKA 284
Cdd:PLN02858 1340 ----EALSSPKKT-DLIDVMSAAKEAMKAVVAEKLRLFGSAGKA 1378
FTBP_aldolase_II cd00453
Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1, ...
 9-280 3.10e-52

Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to yield fructose-1,6-bisphosphate. TBP-aldolase is tetrameric and produces tagarose-1,6-bisphosphate. There is an absolute requirement for a divalent metal ion, usually zinc, and in addition the enzymes are activated by monovalent cations such as Na+. Although structurally similar, the class I aldolases use a different mechanism and are believed to have an independent evolutionary origin.


Pssm-ID: 238255  Cd Length: 340  Bit Score: 173.84  E-value: 3.10e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968   9 MLKKALAGKYAVGQFNINNLEWTQAILKAAEAEKAPVILGVSEGAAKYMGGFKTVVKMTEGLVEDLKIT----------- 77
Cdd:cd00453    4 VFQVAKENNFALPAVNCVGTDSINAVLETAAKVKAPVIVQFSNGGASFIAGKGVKSDVPQGAAILGAISgahhvhqmaeh 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968  78 --VPVAIHLDH--GSSFDSCKAAIDAG-----------FSSVMIDGSHHPIDENIAMTKQVVDYAHAKGVSVEAEIGTVG 142
Cdd:cd00453   84 ygVPVILHTDHcaKKLLPWIDGLLDAGekhfaatgkplFSSHMIDLSEESLQENIEICSKYLERMSKIGMTLEIELGCTG 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968 143 GDEDGVTGGIN-----YADPQECLRVVKE----ANIDALAAALGSVHGPYH-GEPVLGFDEMKEISELTGA--------- 203
Cdd:cd00453  164 GEEDGVDNSHMdasalYTQPEDVDYAYTElskiSPRFTIAASFGNVHGVYKkGNVVLTPTILRDSQEYVSKkhnlphnsl 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968 204 PLVLHGGSGIPEHQIKKAIELGHSKINVNTECQIVWTAAVREKLATDD------------------KVYDPRKVIGPGVD 265
Cdd:cd00453  244 NFVFHGGSGSTAQEIKDSVSYGVVKMNIDTDTQWATWEGVLNYYKANEaylqgqlgnpkgedqpnkKYYDPRVWLRAGQT 323

                        330
                 ....*....|....*
gi 675333968 266 AIIKTVTEKIQEFGS 280
Cdd:cd00453  324 SMIARLEKAFQELNA 338
PRK09197 PRK09197
fructose-bisphosphate aldolase; Provisional
 1-283 1.02e-31

fructose-bisphosphate aldolase; Provisional


Pssm-ID: 236406  Cd Length: 350  Bit Score: 120.29  E-value: 1.02e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968   1 MPIVN---MTDMLKKALAGKYAVGQFNINNLEWTQAILKAAEAEKAPVILGVSEGAAKYMGGfKTV-----VKMTEGLVE 72
Cdd:PRK09197   1 PGVATgedYQEMFDRAKENGFALPAVNVVGTDSINAVLEGAAEAKSPVIIQFSNGGAAFIAG-KGVkddgqGAAVLGAIA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968  73 DLKIT--------VPVAIHLDHGSS--FDSCKAAIDAG-----------FSSVMIDGSHHPIDENIAMTKQVVDYAHAKG 131
Cdd:PRK09197  80 GAKHVhevaehygVPVILHTDHCAKklLPWIDGLLDAGekhfaaggkplFSSHMIDLSEEPLEENIEICSKYLERMAKAG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968 132 VSVEAEIGTVGGDEDGV--TGGIN---YADPQECLRVVKEANIDA----LAAALGSVHGPY-----HGEPVLGFDEMKEI 197
Cdd:PRK09197 160 MTLEIELGVTGGEEDGVdnSHEDNsklYTQPEDVLYAYEALGKISgrftIAASFGNVHGVYkpgnvKLRPEILKDSQEYV 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968 198 SELTGAP-----LVLHGGSGIPEHQIKKAIELGHSKINVNTECQIVWTAAVRE------------------KLATDDKVY 254
Cdd:PRK09197 240 SKKFGLPakpfdFVFHGGSGSTLEEIREAVSYGVVKMNIDTDTQWAFWRGVLDyyfknydylqgqvgnpegEDKPNKKYY 319

                        330       340
                 ....*....|....*....|....*....
gi 675333968 255 DPRKVIGPGVDAIIKTVTEKIQEFGSNGK 283
Cdd:PRK09197 320 DPRVWLRAAEASMAARLEEAFEDLNSIGV 348
FBP_aldolase_IIA cd00946
Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the ...
 8-283 3.30e-31

Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is homodimeric and used in gluconeogenesis and glycolysis. The type A and type B Class II FBPA's differ in the presence and absence of distinct indels in the sequence that result in differing loop lengths in the structures.


Pssm-ID: 238476  Cd Length: 345  Bit Score: 118.63  E-value: 3.30e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968   8 DMLKKALAGKYAVGQFNINNLEWTQAILKAAEAEKAPVILGVSEGAAKYMGGfkTVVKMTE------GLVEDLKIT---- 77
Cdd:cd00946    6 KLFDYAKENGFAIPAVNCTSSSTINAVLEAARDAKSPIIIQFSNGGAAFYAG--KGLKNEKqkasiaGAIAAAHHVrsma 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968  78 ----VPVAIHLDHGSS-----FDsckAAIDAG-----------FSSVMIDGSHHPIDENIAMTKQVVDYAHAKGVSVEAE 137
Cdd:cd00946   84 ehygVPVVLHTDHCAKkllpwFD---GLLEADeeyfkqhgeplFSSHMLDLSEEPLEENIEICKKYLERMAKINMWLEME 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968 138 IGTVGGDEDGV--TGGIN---YADPQECLRVVKEAN-IDA---LAAALGSVHGPYHG-----EPVLGFDEMKEISELTGA 203
Cdd:cd00946  161 IGITGGEEDGVdnSGVDNaelYTQPEDVWYVYEALSkISPnfsIAAAFGNVHGVYKPgnvklQPEILGEHQDYVREKLGL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 675333968 204 P------LVLHGGSGIPEHQIKKAIELGHSKINVNTECQIVWTAAVREKLAT--------------DD----KVYDPRKV 259
Cdd:cd00946  241 AddkplyFVFHGGSGSTKEEIREAISYGVVKMNIDTDTQWAYWEGVRNYYLKnedylqgqignpegPDkpnkKYYDPRVW 320

                        330       340
                 ....*....|....*....|....
gi 675333968 260 IGPGVDAIIKTVTEKIQEFGSNGK 283
Cdd:cd00946  321 LREGEKSMVARVKKAFEDLNSVNK 344
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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