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Conserved domains on  [gi|674751535|gb|AIL28038|]
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DNA gyrase subunit B, partial [Burkholderia cenocepacia]

Protein Classification

DNA gyrase subunit B family protein( domain architecture ID 999984)

DNA gyrase subunit B (GyrB) is the ATPase subunit of DNA gyrase, which is a type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state; may be partial

CATH:  3.30.230.10
EC:  5.6.2.2
Gene Ontology:  GO:0006265|GO:0005524|GO:0003677|GO:0003918
PubMed:  11395412|7980433|12596227
SCOP:  4000168

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
gyrB super family cl36442
DNA gyrase subunit B; Provisional
 2-231 1.53e-151

DNA gyrase subunit B; Provisional


The actual alignment was detected with superfamily member PRK14939:

Pssm-ID: 237860 [Multi-domain]  Cd Length: 756  Bit Score: 439.15  E-value: 1.53e-151
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674751535   2 EVLDNSIDEALAGYCNDIHVTIHADNSISVTDNGRGIPTDVKMndkhEPKRSAAEIVMTELHAGGKFDQNSYKVSGGLHG 81
Cdd:PRK14939  44 EVVDNAIDEALAGHCDDITVTIHADGSVSVSDNGRGIPTDIHP----EEGVSAAEVIMTVLHAGGKFDQNSYKVSGGLHG 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674751535  82 VGVSCVNALSSWLRLTVRRDGKKRFMEFHRGVAqdrvievvdgveVSPMLVTGDTENRGTEVHFMADPTIFGTVEYHYDI 161
Cdd:PRK14939 120 VGVSVVNALSEWLELTIRRDGKIHEQEFEHGVP------------VAPLKVVGETDKTGTEVRFWPSPEIFENTEFDYDI 187

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674751535 162 LAKRMRELSFLNNGVRIRLTDLRSGKEDDFAFAGGVKGFVEFINKTKSTLHPTVFFANGEKDGVGVEVAM 231
Cdd:PRK14939 188 LAKRLRELAFLNSGVRIRLKDERDGKEEEFHYEGGIKAFVEYLNRNKTPLHPNIFYFSGEKDGIGVEVAL 257
 
Name Accession Description Interval E-value
gyrB PRK14939
DNA gyrase subunit B; Provisional
 2-231 1.53e-151

DNA gyrase subunit B; Provisional


Pssm-ID: 237860 [Multi-domain]  Cd Length: 756  Bit Score: 439.15  E-value: 1.53e-151
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674751535   2 EVLDNSIDEALAGYCNDIHVTIHADNSISVTDNGRGIPTDVKMndkhEPKRSAAEIVMTELHAGGKFDQNSYKVSGGLHG 81
Cdd:PRK14939  44 EVVDNAIDEALAGHCDDITVTIHADGSVSVSDNGRGIPTDIHP----EEGVSAAEVIMTVLHAGGKFDQNSYKVSGGLHG 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674751535  82 VGVSCVNALSSWLRLTVRRDGKKRFMEFHRGVAqdrvievvdgveVSPMLVTGDTENRGTEVHFMADPTIFGTVEYHYDI 161
Cdd:PRK14939 120 VGVSVVNALSEWLELTIRRDGKIHEQEFEHGVP------------VAPLKVVGETDKTGTEVRFWPSPEIFENTEFDYDI 187

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674751535 162 LAKRMRELSFLNNGVRIRLTDLRSGKEDDFAFAGGVKGFVEFINKTKSTLHPTVFFANGEKDGVGVEVAM 231
Cdd:PRK14939 188 LAKRLRELAFLNSGVRIRLKDERDGKEEEFHYEGGIKAFVEYLNRNKTPLHPNIFYFSGEKDGIGVEVAL 257
GyrB COG0187
DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair];
2-231 4.46e-123

DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair];


Pssm-ID: 439957 [Multi-domain]  Cd Length: 635  Bit Score: 362.42  E-value: 4.46e-123
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674751535   2 EVLDNSIDEALAGYCNDIHVTIHADNSISVTDNGRGIPTDvkMNDKHepKRSAAEIVMTELHAGGKFDQNSYKVSGGLHG 81
Cdd:COG0187   42 EIVDNSIDEALAGYCDRIEVTLHADGSVTVEDNGRGIPVD--IHPKE--GKSALEVVLTVLHAGGKFDGGSYKVSGGLHG 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674751535  82 VGVSCVNALSSWLRLTVRRDGKKRFMEFHRGVAqdrvievvdgveVSPMLVTGDTENRGTEVHFMADPTIFGTVEYHYDI 161
Cdd:COG0187  118 VGASVVNALSERLEVEVKRDGKIYRQRFERGKP------------VGPLEKIGKTDRTGTTVRFKPDPEIFETTEFDYET 185

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 674751535 162 LAKRMRELSFLNNGVRIRLTDLRSG--KEDDFAFAGGVKGFVEFINKTKSTLHPTVFFANGEKDGVGVEVAM 231
Cdd:COG0187  186 LAERLRELAFLNKGLTITLTDEREEepKEETFHYEGGIKDFVEYLNEDKEPLHPEVIYFEGEKDGIEVEVAL 257
HATPase_GyrB-like cd16928
Histidine kinase-like ATPase domain of the B subunit of DNA gyrase; This family includes ...
 2-191 2.39e-96

Histidine kinase-like ATPase domain of the B subunit of DNA gyrase; This family includes histidine kinase-like ATPase domain of the B subunit of DNA gyrase. Bacterial DNA gyrase is a type II topoisomerase (type II as it transiently cleaves both strands of DNA) which catalyzes the introduction of negative supercoils into DNA, possibly by a mechanism in which one segment of the double-stranded DNA substrate is passed through a transient break in a second segment. It consists of GyrA and GyrB subunits in an A2B2 stoichiometry; GyrA subunits catalyze strand-breakage and reunion reactions, and GyrB subunits hydrolyze ATP. DNA gyrase is found in bacteria, plants and archaea, but as it is absent in humans it is a possible drug target for the treatment of bacterial and parasite infections.


Pssm-ID: 340405 [Multi-domain]  Cd Length: 180  Bit Score: 278.65  E-value: 2.39e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674751535   2 EVLDNSIDEALAGYCNDIHVTIHADNSISVTDNGRGIPTDVKmndkHEPKRSAAEIVMTELHAGGKFDQNSYKVSGGLHG 81
Cdd:cd16928    7 EIVDNSIDEALAGYATEIEVTLHEDNSITVEDNGRGIPVDIH----PKTGKSAVEVVLTVLHAGGKFDGGSYKVSGGLHG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674751535  82 VGVSCVNALSSWLRLTVRRDGKKRFMEFHRGVAqdrvievvdgveVSPMLVTGDTENRGTEVHFMADPTIFGTVEYHYDI 161
Cdd:cd16928   83 VGVSVVNALSERLEVEVKRDGKIYRQEFSRGGP------------LTPLEVIGETKKTGTTVRFWPDPEIFEKTEFDFDT 150

                        170       180       190
                 ....*....|....*....|....*....|
gi 674751535 162 LAKRMRELSFLNNGVRIRLTDLRSGKEDDF 191
Cdd:cd16928  151 LKRRLRELAFLNKGLKIVLEDERTGKEEVF 180
TOP2c smart00433
TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE
 2-231 1.50e-92

TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE


Pssm-ID: 214659 [Multi-domain]  Cd Length: 594  Bit Score: 282.91  E-value: 1.50e-92
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674751535     2 EVLDNSIDEALAGYCNDIHVTIHADNSISVTDNGRGIPTDvkMNDKHepKRSAAEIVMTELHAGGKFDQNSYKVSGGLHG 81
Cdd:smart00433   8 EIVDNAADEALAGYMDTIKVTIDKDNSISVEDNGRGIPVE--IHPKE--KKYAPEVIFTVLHAGGKFDDDAYKVSGGLHG 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674751535    82 VGVSCVNALSSWLRLTVRRDGKKRFMEFHRGvaqdrvievvdGVEVSPMLVTGDTENRGTEVHFMADPTIFG-TVEYHYD 160
Cdd:smart00433  84 VGASVVNALSTEFEVEVARDGKEYKQSFSNN-----------GKPLSEPKIIGDTKKDGTKVTFKPDLEIFGmTTDDDFE 152

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 674751535   161 ILAKRMRELSFLNNGVRIRLTDLRSGKEDDFAFAGGVKGFVEFINKTKSTLHPTVFFANGEKDGVGVEVAM 231
Cdd:smart00433 153 LLKRRLRELAFLNKGVKITLNDERSDEEKTFLFEGGIKDYVELLNKNKELLSPEPTYIEGEKDNIRVEVAF 223
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 2-101 9.21e-09

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 51.60  E-value: 9.21e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674751535    2 EVLDNSIDEAlaGYCNDIHVTIHADN--SISVTDNGRGIPTdvkmnDKHEpkrsaaeivmtelHAGGKFDQnSYKVSGGL 79
Cdd:pfam02518  12 NLLDNALKHA--AKAGEITVTLSEGGelTLTVEDNGIGIPP-----EDLP-------------RIFEPFST-ADKRGGGG 70

                          90       100
                  ....*....|....*....|..
gi 674751535   80 HGVGVSCVNALSSWLRLTVRRD 101
Cdd:pfam02518  71 TGLGLSIVRKLVELLGGTITVE 92
 
Name Accession Description Interval E-value
gyrB PRK14939
DNA gyrase subunit B; Provisional
 2-231 1.53e-151

DNA gyrase subunit B; Provisional


Pssm-ID: 237860 [Multi-domain]  Cd Length: 756  Bit Score: 439.15  E-value: 1.53e-151
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674751535   2 EVLDNSIDEALAGYCNDIHVTIHADNSISVTDNGRGIPTDVKMndkhEPKRSAAEIVMTELHAGGKFDQNSYKVSGGLHG 81
Cdd:PRK14939  44 EVVDNAIDEALAGHCDDITVTIHADGSVSVSDNGRGIPTDIHP----EEGVSAAEVIMTVLHAGGKFDQNSYKVSGGLHG 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674751535  82 VGVSCVNALSSWLRLTVRRDGKKRFMEFHRGVAqdrvievvdgveVSPMLVTGDTENRGTEVHFMADPTIFGTVEYHYDI 161
Cdd:PRK14939 120 VGVSVVNALSEWLELTIRRDGKIHEQEFEHGVP------------VAPLKVVGETDKTGTEVRFWPSPEIFENTEFDYDI 187

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674751535 162 LAKRMRELSFLNNGVRIRLTDLRSGKEDDFAFAGGVKGFVEFINKTKSTLHPTVFFANGEKDGVGVEVAM 231
Cdd:PRK14939 188 LAKRLRELAFLNSGVRIRLKDERDGKEEEFHYEGGIKAFVEYLNRNKTPLHPNIFYFSGEKDGIGVEVAL 257
GyrB COG0187
DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair];
2-231 4.46e-123

DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair];


Pssm-ID: 439957 [Multi-domain]  Cd Length: 635  Bit Score: 362.42  E-value: 4.46e-123
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674751535   2 EVLDNSIDEALAGYCNDIHVTIHADNSISVTDNGRGIPTDvkMNDKHepKRSAAEIVMTELHAGGKFDQNSYKVSGGLHG 81
Cdd:COG0187   42 EIVDNSIDEALAGYCDRIEVTLHADGSVTVEDNGRGIPVD--IHPKE--GKSALEVVLTVLHAGGKFDGGSYKVSGGLHG 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674751535  82 VGVSCVNALSSWLRLTVRRDGKKRFMEFHRGVAqdrvievvdgveVSPMLVTGDTENRGTEVHFMADPTIFGTVEYHYDI 161
Cdd:COG0187  118 VGASVVNALSERLEVEVKRDGKIYRQRFERGKP------------VGPLEKIGKTDRTGTTVRFKPDPEIFETTEFDYET 185

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 674751535 162 LAKRMRELSFLNNGVRIRLTDLRSG--KEDDFAFAGGVKGFVEFINKTKSTLHPTVFFANGEKDGVGVEVAM 231
Cdd:COG0187  186 LAERLRELAFLNKGLTITLTDEREEepKEETFHYEGGIKDFVEYLNEDKEPLHPEVIYFEGEKDGIEVEVAL 257
gyrB PRK05644
DNA gyrase subunit B; Validated
 2-231 1.67e-120

DNA gyrase subunit B; Validated


Pssm-ID: 235542 [Multi-domain]  Cd Length: 638  Bit Score: 355.94  E-value: 1.67e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674751535   2 EVLDNSIDEALAGYCNDIHVTIHADNSISVTDNGRGIPTDVkmndkHEP-KRSAAEIVMTELHAGGKFDQNSYKVSGGLH 80
Cdd:PRK05644  44 EIVDNSIDEALAGYCDHIEVTINEDGSITVTDNGRGIPVDI-----HPKtGKPAVEVVLTVLHAGGKFGGGGYKVSGGLH 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674751535  81 GVGVSCVNALSSWLRLTVRRDGKKRFMEFHRGVAqdrvievvdgveVSPMLVTGDTENRGTEVHFMADPTIFGTVEYHYD 160
Cdd:PRK05644 119 GVGVSVVNALSTWLEVEVKRDGKIYYQEYERGVP------------VTPLEVIGETDETGTTVTFKPDPEIFETTEFDYD 186

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 674751535 161 ILAKRMRELSFLNNGVRIRLTDLRSG--KEDDFAFAGGVKGFVEFINKTKSTLHPTVFFANGEKDGVGVEVAM 231
Cdd:PRK05644 187 TLATRLRELAFLNKGLKITLTDEREGeeKEETFHYEGGIKEYVEYLNRNKEPLHEEPIYFEGEKDGIEVEVAM 259
HATPase_GyrB-like cd16928
Histidine kinase-like ATPase domain of the B subunit of DNA gyrase; This family includes ...
 2-191 2.39e-96

Histidine kinase-like ATPase domain of the B subunit of DNA gyrase; This family includes histidine kinase-like ATPase domain of the B subunit of DNA gyrase. Bacterial DNA gyrase is a type II topoisomerase (type II as it transiently cleaves both strands of DNA) which catalyzes the introduction of negative supercoils into DNA, possibly by a mechanism in which one segment of the double-stranded DNA substrate is passed through a transient break in a second segment. It consists of GyrA and GyrB subunits in an A2B2 stoichiometry; GyrA subunits catalyze strand-breakage and reunion reactions, and GyrB subunits hydrolyze ATP. DNA gyrase is found in bacteria, plants and archaea, but as it is absent in humans it is a possible drug target for the treatment of bacterial and parasite infections.


Pssm-ID: 340405 [Multi-domain]  Cd Length: 180  Bit Score: 278.65  E-value: 2.39e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674751535   2 EVLDNSIDEALAGYCNDIHVTIHADNSISVTDNGRGIPTDVKmndkHEPKRSAAEIVMTELHAGGKFDQNSYKVSGGLHG 81
Cdd:cd16928    7 EIVDNSIDEALAGYATEIEVTLHEDNSITVEDNGRGIPVDIH----PKTGKSAVEVVLTVLHAGGKFDGGSYKVSGGLHG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674751535  82 VGVSCVNALSSWLRLTVRRDGKKRFMEFHRGVAqdrvievvdgveVSPMLVTGDTENRGTEVHFMADPTIFGTVEYHYDI 161
Cdd:cd16928   83 VGVSVVNALSERLEVEVKRDGKIYRQEFSRGGP------------LTPLEVIGETKKTGTTVRFWPDPEIFEKTEFDFDT 150

                        170       180       190
                 ....*....|....*....|....*....|
gi 674751535 162 LAKRMRELSFLNNGVRIRLTDLRSGKEDDF 191
Cdd:cd16928  151 LKRRLRELAFLNKGLKIVLEDERTGKEEVF 180
TOP2c smart00433
TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE
 2-231 1.50e-92

TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE


Pssm-ID: 214659 [Multi-domain]  Cd Length: 594  Bit Score: 282.91  E-value: 1.50e-92
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674751535     2 EVLDNSIDEALAGYCNDIHVTIHADNSISVTDNGRGIPTDvkMNDKHepKRSAAEIVMTELHAGGKFDQNSYKVSGGLHG 81
Cdd:smart00433   8 EIVDNAADEALAGYMDTIKVTIDKDNSISVEDNGRGIPVE--IHPKE--KKYAPEVIFTVLHAGGKFDDDAYKVSGGLHG 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674751535    82 VGVSCVNALSSWLRLTVRRDGKKRFMEFHRGvaqdrvievvdGVEVSPMLVTGDTENRGTEVHFMADPTIFG-TVEYHYD 160
Cdd:smart00433  84 VGASVVNALSTEFEVEVARDGKEYKQSFSNN-----------GKPLSEPKIIGDTKKDGTKVTFKPDLEIFGmTTDDDFE 152

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 674751535   161 ILAKRMRELSFLNNGVRIRLTDLRSGKEDDFAFAGGVKGFVEFINKTKSTLHPTVFFANGEKDGVGVEVAM 231
Cdd:smart00433 153 LLKRRLRELAFLNKGVKITLNDERSDEEKTFLFEGGIKDYVELLNKNKELLSPEPTYIEGEKDNIRVEVAF 223
PRK05559 PRK05559
DNA topoisomerase IV subunit B; Reviewed
 2-231 2.29e-90

DNA topoisomerase IV subunit B; Reviewed


Pssm-ID: 235501 [Multi-domain]  Cd Length: 631  Bit Score: 278.14  E-value: 2.29e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674751535   2 EVLDNSIDEALAGYCNDIHVTIHADNSISVTDNGRGIPTDvkmndKH-EPKRSAAEIVMTELHAGGKFDQNSYKVSGGLH 80
Cdd:PRK05559  44 EVIDNSVDEALAGHGKRIEVTLHADGSVSVRDNGRGIPVG-----IHpEEGKSGVEVILTKLHAGGKFSNKAYKFSGGLH 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674751535  81 GVGVSCVNALSSWLRLTVRRDGKKRFMEFHRGVAqdrvievvdgveVSPMLVTGDT--ENRGTEVHFMADPTIFGTVEYH 158
Cdd:PRK05559 119 GVGVSVVNALSSRLEVEVKRDGKVYRQRFEGGDP------------VGPLEVVGTAgkRKTGTRVRFWPDPKIFDSPKFS 186

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 674751535 159 YDILAKRMRELSFLNNGVRIRLTDLRsgKEDDFAFAGGVKGFVEFINKTKSTLHP-TVFFANGEKDGVGVEVAM 231
Cdd:PRK05559 187 PERLKERLRSKAFLLPGLTITLNDER--ERQTFHYENGLKDYLAELNEGKETLPEeFVGSFEGEAEGEAVEWAL 258
PTZ00109 PTZ00109
DNA gyrase subunit b; Provisional
 2-231 1.35e-43

DNA gyrase subunit b; Provisional


Pssm-ID: 240272 [Multi-domain]  Cd Length: 903  Bit Score: 156.19  E-value: 1.35e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674751535   2 EVLDNSIDEALAGYCNDIHVTIHADNSISVTDNGRGIPTDVkmndkHEP-KRSAAEIVMTELHAGGKF------------ 68
Cdd:PTZ00109 136 EILDNSVDEYLAGECNKITVVLHKDGSVEISDNGRGIPCDV-----SEKtGKSGLETVLTVLHSGGKFqdtfpknsrsdk 210

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674751535  69 --DQNS--------------------------YKVSGGLHGVGVSCVNALSSWLRLTVRRDGKKRFMEFHRGVAqdrvie 120
Cdd:PTZ00109 211 seDKNDtksskkgksshvkgpkeakekessqmYEYSSGLHGVGLSVVNALSSFLKVDVFKGGKIYSIELSKGKV------ 284

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674751535 121 vvdgveVSPMLVTGDTEN-RGTEVHFMAD-PTIFGTVEYHY--------------DILAKRMRELSFLNNGVRIRLTDLR 184
Cdd:PTZ00109 285 ------TKPLSVFSCPLKkRGTTIHFLPDyKHIFKTHHQHTeteeeegckngfnlDLIKNRIHELSYLNPGLTFYLVDER 358

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 674751535 185 SGKEDDFAF------AGGVKGFVEFINKTKSTLHPTVFFAN--GEKDGVGVEVAM 231
Cdd:PTZ00109 359 IANENNFYPyetikhEGGTREFLEELIKDKTPLYKDINIISirGVIKNVNVEVSL 413
39 PHA02569
DNA topoisomerase II large subunit; Provisional
 2-205 5.95e-16

DNA topoisomerase II large subunit; Provisional


Pssm-ID: 177398 [Multi-domain]  Cd Length: 602  Bit Score: 76.33  E-value: 5.95e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674751535   2 EVLDNSIDEALAG---YCNDIHVTIHaDNSISVTDNGRGIPTD-VKMNDKHE-PKRSAAeivMTELHAGGKFDqNSYKVS 76
Cdd:PHA02569  52 EIIDNSVDEAIRTnfkFANKIDVTIK-NNQVTVSDNGRGIPQAmVTTPEGEEiPGPVAA---WTRTKAGSNFD-DTNRVT 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674751535  77 GGLHGVGVSCVNALSSWLrLTVRRDGkKRFMefhrgvaqdrVIEVVDGVEvSPMLVTGDTENRGTEVHFMADPTIFGTV- 155
Cdd:PHA02569 127 GGMNGVGSSLTNFFSVLF-IGETCDG-KNEV----------TVNCSNGAE-NISWSTKPGKGKGTSVTFIPDFSHFEVNg 193

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 674751535 156 --EYHYDILAKRMRELS-------FLNNGVRIRLTDLRSGK---------EDD---FAFAGGVKGF--VEFIN 205
Cdd:PHA02569 194 ldQQYLDIILDRLQTLAvvfpdikFTFNGKKVSGKFKKYAKqfgddtivqENDnvsIALAPSPDGFrqLSFVN 266
HATPase_c smart00387
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
 2-104 8.53e-11

Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.


Pssm-ID: 214643 [Multi-domain]  Cd Length: 111  Bit Score: 57.27  E-value: 8.53e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674751535     2 EVLDNSIDEALAGycNDIHVTIHADN---SISVTDNGRGIPtdvkmndkhepkrsaAEIVMTELHAGGKFDQNSYKVSGg 78
Cdd:smart00387  12 NLLDNAIKYTPEG--GRITVTLERDGdhvEITVEDNGPGIP---------------PEDLEKIFEPFFRTDKRSRKIGG- 73

                           90       100
                   ....*....|....*....|....*.
gi 674751535    79 lHGVGVSCVNALSSWLRLTVRRDGKK 104
Cdd:smart00387  74 -TGLGLSIVKKLVELHGGEISVESEP 98
HATPase_c pfam02518
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
 2-101 9.21e-09

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 460579 [Multi-domain]  Cd Length: 109  Bit Score: 51.60  E-value: 9.21e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674751535    2 EVLDNSIDEAlaGYCNDIHVTIHADN--SISVTDNGRGIPTdvkmnDKHEpkrsaaeivmtelHAGGKFDQnSYKVSGGL 79
Cdd:pfam02518  12 NLLDNALKHA--AKAGEITVTLSEGGelTLTVEDNGIGIPP-----EDLP-------------RIFEPFST-ADKRGGGG 70

                          90       100
                  ....*....|....*....|..
gi 674751535   80 HGVGVSCVNALSSWLRLTVRRD 101
Cdd:pfam02518  71 TGLGLSIVRKLVELLGGTITVE 92
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 5-184 1.79e-08

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 54.28  E-value: 1.79e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674751535    5 DNSIDEALAGYCNDIHVTI-HADNSISVTDNGRGIPtdVKMNDKHepKRSAAEIVMTELHAGGKFDQNSYKVSGGLHGVG 83
Cdd:PTZ00108   71 DNKARDKGGHRMTYIKVTIdEENGEISVYNDGEGIP--VQIHKEH--KIYVPEMIFGHLLTSSNYDDTEKRVTGGRNGFG 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674751535   84 VSCVNALSSWLRLTVR--RDGKKRFMEF--HRGVAQDRVIEVVDGVEvspmlvtgdtenRGTEVHFMADPTIFGTVEY-- 157
Cdd:PTZ00108  147 AKLTNIFSTKFTVECVdsKSGKKFKMTWtdNMSKKSEPRITSYDGKK------------DYTKVTFYPDYAKFGMTEFdd 214

                         170       180
                  ....*....|....*....|....*...
gi 674751535  158 -HYDILAKRMRELSFLNNGVRIRLTDLR 184
Cdd:PTZ00108  215 dMLRLLKKRVYDLAGCFGKLKVYLNGER 242
HATPase_TopII-like cd16930
Histidine kinase-like ATPase domain of eukaryotic topoisomerase II; This family includes the ...
 17-106 2.86e-07

Histidine kinase-like ATPase domain of eukaryotic topoisomerase II; This family includes the histidine kinase-like ATPase (HATpase) domains of human topoisomerase IIA (TopIIA) and TopIIB, Saccharomyces cerevisae TOP2p, and related proteins. These proteins catalyze the passage of DNA double strands through a transient double-strand break in the presence of ATP.


Pssm-ID: 340407 [Multi-domain]  Cd Length: 147  Bit Score: 48.49  E-value: 2.86e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674751535  17 NDIHVTIHAD-NSISVTDNGRGIPtdVKMNDKHepKRSAAEIVMTELHAGGKFDQNSYKVSGGLHGVGVSCVNALSSWLR 95
Cdd:cd16930   27 TCIKVTIDPEnNEISVWNNGKGIP--VVIHKEE--KIYVPEMIFGHLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTEFT 102

                         90
                 ....*....|..
gi 674751535  96 L-TVRRDGKKRF 106
Cdd:cd16930  103 VeTADSESKKKF 114
PLN03128 PLN03128
DNA topoisomerase 2; Provisional
 16-184 6.61e-07

DNA topoisomerase 2; Provisional


Pssm-ID: 215593 [Multi-domain]  Cd Length: 1135  Bit Score: 49.71  E-value: 6.61e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674751535   16 CNDIHVTIHAD-NSISVTDNGRGIPtdVKMNDKHE---PkrsaaEIVMTELHAGGKFDQNSYKVSGGLHGVGVSCVNALS 91
Cdd:PLN03128   74 MDSLKVDIDVEqNTISVYNNGKGIP--VEIHKEEGvyvP-----ELIFGHLLTSSNFDDNEKKTTGGRNGYGAKLANIFS 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 674751535   92 SwlrltvrrdgkkrfmEFhrgvaqdrVIEVVDG---------------VEVSPMLVTGDTENRGTEVHFMADPTIFGTVE 156
Cdd:PLN03128  147 T---------------EF--------TVETADGnrgkkykqvftnnmsVKSEPKITSCKASENWTKITFKPDLAKFNMTR 203

                         170       180       190
                  ....*....|....*....|....*....|..
gi 674751535  157 YHYDI---LAKRMRELS-FLNNGVRIRLTDLR 184
Cdd:PLN03128  204 LDEDVvalMSKRVYDIAgCLGKKLKVELNGKK 235
HATPase cd00075
Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ...
 2-41 7.71e-03

Histidine kinase-like ATPase domain; This superfamily includes the histidine kinase-like ATPase (HATPase) domains of several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein 90 (HSP90), phytochrome-like ATPases and DNA mismatch repair proteins. Domains belonging to this superfamily are also referred to as GHKL (gyrase, heat-shock protein 90, histidine kinase, MutL) ATPase domains.


Pssm-ID: 340391 [Multi-domain]  Cd Length: 102  Bit Score: 34.89  E-value: 7.71e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 674751535   2 EVLDNSIDEALAGycNDIHVTIHADNS---ISVTDNGRGIPTD 41
Cdd:cd00075    7 NLLDNALKYSPPG--GTIEISLRQEGDgvvLEVEDNGPGIPEE 47
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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