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Conserved domains on  [gi|671706948|gb|AII80601|]
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beta-tubulin, partial [Aspergillus chevalieri]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN00220 super family cl30499
tubulin beta chain; Provisional
 1-97 5.69e-66

tubulin beta chain; Provisional


The actual alignment was detected with superfamily member PLN00220:

Pssm-ID: 215107 [Multi-domain]  Cd Length: 447  Bit Score: 204.67  E-value: 5.69e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671706948   1 GNQIGAAFWQTISGEHGLDGSGVYNGSSDLQLERMNVYFNEASNNKYVPRAVLVDLEPGTMDAVRAGPFGQLFRPDNFVF 80
Cdd:PLN00220  13 GNQIGAKFWEVVCDEHGIDPTGTYHGDSDLQLERINVYYNEASGGRYVPRAVLMDLEPGTMDSVRSGPYGQIFRPDNFVF 92

                         90
                 ....*....|....*..
gi 671706948  81 GQSGAGNNWAKGHYTEG 97
Cdd:PLN00220  93 GQSGAGNNWAKGHYTEG 109
 
Name Accession Description Interval E-value
PLN00220 PLN00220
tubulin beta chain; Provisional
 1-97 5.69e-66

tubulin beta chain; Provisional


Pssm-ID: 215107 [Multi-domain]  Cd Length: 447  Bit Score: 204.67  E-value: 5.69e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671706948   1 GNQIGAAFWQTISGEHGLDGSGVYNGSSDLQLERMNVYFNEASNNKYVPRAVLVDLEPGTMDAVRAGPFGQLFRPDNFVF 80
Cdd:PLN00220  13 GNQIGAKFWEVVCDEHGIDPTGTYHGDSDLQLERINVYYNEASGGRYVPRAVLMDLEPGTMDSVRSGPYGQIFRPDNFVF 92

                         90
                 ....*....|....*..
gi 671706948  81 GQSGAGNNWAKGHYTEG 97
Cdd:PLN00220  93 GQSGAGNNWAKGHYTEG 109
beta_tubulin cd02187
The beta-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, ...
 1-97 2.84e-64

The beta-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. The alpha/beta-tubulin heterodimer is the structural subunit of microtubules. The alpha- and beta-tubulins share 40% amino-acid sequence identity, exist in several isotype forms, and undergo a variety of posttranslational modifications. The structures of alpha- and beta-tubulin are basically identical: each monomer is formed by a core of two beta-sheets surrounded by alpha-helices. The monomer structure is very compact, but can be divided into three regions based on function: the amino-terminal nucleotide-binding region, an intermediate taxol-binding region and the carboxy-terminal region which probably constitutes the binding surface for motor proteins.


Pssm-ID: 276956 [Multi-domain]  Cd Length: 425  Bit Score: 199.33  E-value: 2.84e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671706948   1 GNQIGAAFWQTISGEHGLDGSGVYNGSSDLQLERMNVYFNEASNNKYVPRAVLVDLEPGTMDAVRAGPFGQLFRPDNFVF 80
Cdd:cd02187   12 GNQIGAKFWETISKEHGIDPDGTYKGDSDLQLERINVYFNEASGGKYVPRAVLVDLEPGTIDSVRSGPYGQLFRPDNFVF 91

                         90
                 ....*....|....*..
gi 671706948  81 GQSGAGNNWAKGHYTEG 97
Cdd:cd02187   92 GQSGAGNNWAKGHYTEG 108
Tubulin pfam00091
Tubulin/FtsZ family, GTPase domain; This family includes the tubulin alpha, beta and gamma ...
 1-97 2.86e-22

Tubulin/FtsZ family, GTPase domain; This family includes the tubulin alpha, beta and gamma chains, as well as the bacterial FtsZ family of proteins. Members of this family are involved in polymer formation. FtsZ is the polymer-forming protein of bacterial cell division. It is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ and tubulin are GTPases. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules.


Pssm-ID: 459669 [Multi-domain]  Cd Length: 190  Bit Score: 85.35  E-value: 2.86e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671706948    1 GNQIGAAFWQTISGEHGLDgsgvyngssdlqleRMNVYFNEASNNKYVPRAVLVDLEPGTMDAVRAGpfgqlFRPDNFVF 80
Cdd:pfam00091  11 GNNIGNALWELLCLEHGID--------------SLNVFFSESGSVEFIPRSLAIDTDPQALNEIKAG-----FNPNKILL 71

                          90
                  ....*....|....*..
gi 671706948   81 GQSGAGNNWAKGHYTEG 97
Cdd:pfam00091  72 GKEGTGGNGAGGYPEIG 88
Tubulin smart00864
Tubulin/FtsZ family, GTPase domain; This domain is found in all tubulin chains, as well as the ...
 36-97 2.11e-20

Tubulin/FtsZ family, GTPase domain; This domain is found in all tubulin chains, as well as the bacterial FtsZ family of proteins. These proteins are involved in polymer formation. Tubulin is the major component of microtubules, while FtsZ is the polymer-forming protein of bacterial cell division, it is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ and tubulin are GTPases, this entry is the GTPase domain. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in bacteria and archaea.


Pssm-ID: 214867 [Multi-domain]  Cd Length: 192  Bit Score: 80.61  E-value: 2.11e-20
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 671706948    36 NVYFNEasnNKYVPRAVLVDLEPGTMDAVRAGPFGQLFRPDNFVFGQSGAGNNWAKGHYTEG 97
Cdd:smart00864   2 IKVFGV---GGGGPNAVNVDLEPGVIDGVRANTDAQALNPESLASGKIQAGNNWTRGLGAGA 60
 
Name Accession Description Interval E-value
PLN00220 PLN00220
tubulin beta chain; Provisional
 1-97 5.69e-66

tubulin beta chain; Provisional


Pssm-ID: 215107 [Multi-domain]  Cd Length: 447  Bit Score: 204.67  E-value: 5.69e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671706948   1 GNQIGAAFWQTISGEHGLDGSGVYNGSSDLQLERMNVYFNEASNNKYVPRAVLVDLEPGTMDAVRAGPFGQLFRPDNFVF 80
Cdd:PLN00220  13 GNQIGAKFWEVVCDEHGIDPTGTYHGDSDLQLERINVYYNEASGGRYVPRAVLMDLEPGTMDSVRSGPYGQIFRPDNFVF 92

                         90
                 ....*....|....*..
gi 671706948  81 GQSGAGNNWAKGHYTEG 97
Cdd:PLN00220  93 GQSGAGNNWAKGHYTEG 109
PTZ00010 PTZ00010
tubulin beta chain; Provisional
 1-97 1.59e-65

tubulin beta chain; Provisional


Pssm-ID: 240228 [Multi-domain]  Cd Length: 445  Bit Score: 203.47  E-value: 1.59e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671706948   1 GNQIGAAFWQTISGEHGLDGSGVYNGSSDLQLERMNVYFNEASNNKYVPRAVLVDLEPGTMDAVRAGPFGQLFRPDNFVF 80
Cdd:PTZ00010  13 GNQIGSKFWEVISDEHGIDPTGTYQGDSDLQLERINVYYNEATGGRYVPRAVLMDLEPGTMDSVRAGPYGQLFRPDNFIF 92

                         90
                 ....*....|....*..
gi 671706948  81 GQSGAGNNWAKGHYTEG 97
Cdd:PTZ00010  93 GQSGAGNNWAKGHYTEG 109
beta_tubulin cd02187
The beta-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, ...
 1-97 2.84e-64

The beta-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. The alpha/beta-tubulin heterodimer is the structural subunit of microtubules. The alpha- and beta-tubulins share 40% amino-acid sequence identity, exist in several isotype forms, and undergo a variety of posttranslational modifications. The structures of alpha- and beta-tubulin are basically identical: each monomer is formed by a core of two beta-sheets surrounded by alpha-helices. The monomer structure is very compact, but can be divided into three regions based on function: the amino-terminal nucleotide-binding region, an intermediate taxol-binding region and the carboxy-terminal region which probably constitutes the binding surface for motor proteins.


Pssm-ID: 276956 [Multi-domain]  Cd Length: 425  Bit Score: 199.33  E-value: 2.84e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671706948   1 GNQIGAAFWQTISGEHGLDGSGVYNGSSDLQLERMNVYFNEASNNKYVPRAVLVDLEPGTMDAVRAGPFGQLFRPDNFVF 80
Cdd:cd02187   12 GNQIGAKFWETISKEHGIDPDGTYKGDSDLQLERINVYFNEASGGKYVPRAVLVDLEPGTIDSVRSGPYGQLFRPDNFVF 91

                         90
                 ....*....|....*..
gi 671706948  81 GQSGAGNNWAKGHYTEG 97
Cdd:cd02187   92 GQSGAGNNWAKGHYTEG 108
gamma_tubulin cd02188
The gamma-tubulin family; Gamma-tubulin is a ubiquitous phylogenetically conserved member of ...
 1-97 1.13e-32

The gamma-tubulin family; Gamma-tubulin is a ubiquitous phylogenetically conserved member of tubulin superfamily. Gamma is a low abundance protein present within the cells in both various types of microtubule-organizing centers and cytoplasmic protein complexes. Gamma-tubulin recruits the alpha/beta-tubulin dimers that form the minus ends of microtubules and is thought to be involved in microtubule nucleation and capping.


Pssm-ID: 276957 [Multi-domain]  Cd Length: 430  Bit Score: 117.26  E-value: 1.13e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671706948   1 GNQIGAAFWQTISGEHGLDGSGVYNGSSDLQLERMNVYFNEASNNKYVPRAVLVDLEPGTMDAVRAGPFGQLFRPDNFVF 80
Cdd:cd02188   12 GNQIGSEFWKQLCSEHGISPDGSLEDFATDGNDRKDVFFYQADDEHYIPRAILLDLEPRVINSIQNSPYKNLFNPENIYL 91

                         90
                 ....*....|....*....
gi 671706948  81 GQ--SGAGNNWAKGhYTEG 97
Cdd:cd02188   92 SKegGGAGNNWASG-YSQG 109
alpha_tubulin cd02186
The alpha-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, ...
 1-97 2.56e-30

The alpha-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. The alpha/beta-tubulin heterodimer is the structural subunit of microtubules. The alpha- and beta-tubulins share 40% amino-acid sequence identity, exist in several isotype forms, and undergo a variety of posttranslational modifications. The structures of alpha- and beta-tubulin are basically identical: each monomer is formed by a core of two beta-sheets surrounded by alpha-helices. The monomer structure is very compact, but can be divided into three regions based on function: the amino-terminal nucleotide-binding region, an intermediate taxol-binding region and the carboxy-terminal region which probably constitutes the binding surface for motor proteins.


Pssm-ID: 276955 [Multi-domain]  Cd Length: 434  Bit Score: 110.71  E-value: 2.56e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671706948   1 GNQIGAAFWQTISGEHGL--DGSGVYNGSSDLQLERMNVYFNEASNNKYVPRAVLVDLEPGTMDAVRAGPFGQLFRPDNF 78
Cdd:cd02186   12 GVQIGNACWELFCLEHGIqpDGQMPSDKTIGGDDDNFNTFFSETGSGKYVPRAVFVDLEPTVIDEIRTGPYRQLFHPEQL 91

                         90
                 ....*....|....*....
gi 671706948  79 VFGQSGAGNNWAKGHYTEG 97
Cdd:cd02186   92 ISGKEDAANNFARGYYTIG 110
PTZ00335 PTZ00335
tubulin alpha chain; Provisional
 1-97 4.73e-25

tubulin alpha chain; Provisional


Pssm-ID: 185562 [Multi-domain]  Cd Length: 448  Bit Score: 96.70  E-value: 4.73e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671706948   1 GNQIGAAFWQTISGEHGL--DGSGVYNGSSDLQLERMNVYFNEASNNKYVPRAVLVDLEPGTMDAVRAGPFGQLFRPDNF 78
Cdd:PTZ00335  13 GIQVGNACWELFCLEHGIqpDGQMPSDKNIGVEDDAFNTFFSETGAGKHVPRCVFLDLEPTVIDEVRTGTYRQLFHPEQL 92

                         90
                 ....*....|....*....
gi 671706948  79 VFGQSGAGNNWAKGHYTEG 97
Cdd:PTZ00335  93 ISGKEDAANNFARGHYTIG 111
PLN00221 PLN00221
tubulin alpha chain; Provisional
 1-97 2.27e-24

tubulin alpha chain; Provisional


Pssm-ID: 177802  Cd Length: 450  Bit Score: 94.88  E-value: 2.27e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671706948   1 GNQIGAAFWQTISGEHGL--DGSGVYNGSSDLQLERMNVYFNEASNNKYVPRAVLVDLEPGTMDAVRAGPFGQLFRPDNF 78
Cdd:PLN00221  13 GIQVGNACWELYCLEHGIqpDGQMPSDKTVGGGDDAFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQL 92

                         90
                 ....*....|....*....
gi 671706948  79 VFGQSGAGNNWAKGHYTEG 97
Cdd:PLN00221  93 ISGKEDAANNFARGHYTIG 111
PLN00222 PLN00222
tubulin gamma chain; Provisional
 1-97 4.25e-24

tubulin gamma chain; Provisional


Pssm-ID: 215108 [Multi-domain]  Cd Length: 454  Bit Score: 94.14  E-value: 4.25e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671706948   1 GNQIGAAFWQTISGEHGLDGSGVYNGSSDLQLERMNVYFNEASNNKYVPRAVLVDLEPGTMDAVRAGPFGQLFRPDNFVF 80
Cdd:PLN00222  14 GNQIGMEFWKQLCLEHGISKDGILEDFATQGGDRKDVFFYQADDEHYIPRALLIDLEPRVINGIQNSEYRNLYNHENIFV 93

                         90
                 ....*....|....*....
gi 671706948  81 GQS--GAGNNWAKGhYTEG 97
Cdd:PLN00222  94 SDHggGAGNNWASG-YHQG 111
Tubulin cd06059
The tubulin superfamily and related homologs; The tubulin superfamily includes five distinct ...
 1-97 2.55e-22

The tubulin superfamily and related homologs; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. The alpha/beta-tubulin heterodimer is the structural subunit of microtubules. The alpha- and beta-tubulins share 40% amino-acid sequence identity, exist in several isotype forms, and undergo a variety of posttranslational modifications. The structures of alpha- and beta-tubulin are basically identical: each monomer is formed by a core of two beta-sheets surrounded by alpha-helices. The monomer structure is very compact, but can be divided into three regions based on function: the amino-terminal nucleotide-binding region, an intermediate taxol-binding region and the carboxy-terminal region which probably constitutes the binding surface for motor proteins. Also included in this group is the mitochondrial Misato/DML1 protein family, involved in mitochondrial fusion and in mitochondrial distribution and morphology.


Pssm-ID: 276963 [Multi-domain]  Cd Length: 387  Bit Score: 88.80  E-value: 2.55e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671706948   1 GNQIGAAFWQTIsgehgldgsgvyngssdlqlermnvyfneasnnkyvpRAVLVDLEPGTMDAVRAGPFGQLFRPDNFVF 80
Cdd:cd06059   11 GNQIGDRFWELA-------------------------------------RAVLVDMEEGVINEVLKGPLGQLFDPNQFVT 53

                         90
                 ....*....|....*..
gi 671706948  81 GQSGAGNNWAKGHYTEG 97
Cdd:cd06059   54 GVSGAGNNWAVGYYVYG 70
Tubulin pfam00091
Tubulin/FtsZ family, GTPase domain; This family includes the tubulin alpha, beta and gamma ...
 1-97 2.86e-22

Tubulin/FtsZ family, GTPase domain; This family includes the tubulin alpha, beta and gamma chains, as well as the bacterial FtsZ family of proteins. Members of this family are involved in polymer formation. FtsZ is the polymer-forming protein of bacterial cell division. It is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ and tubulin are GTPases. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules.


Pssm-ID: 459669 [Multi-domain]  Cd Length: 190  Bit Score: 85.35  E-value: 2.86e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671706948    1 GNQIGAAFWQTISGEHGLDgsgvyngssdlqleRMNVYFNEASNNKYVPRAVLVDLEPGTMDAVRAGpfgqlFRPDNFVF 80
Cdd:pfam00091  11 GNNIGNALWELLCLEHGID--------------SLNVFFSESGSVEFIPRSLAIDTDPQALNEIKAG-----FNPNKILL 71

                          90
                  ....*....|....*..
gi 671706948   81 GQSGAGNNWAKGHYTEG 97
Cdd:pfam00091  72 GKEGTGGNGAGGYPEIG 88
delta_zeta_tubulin-like cd02189
The delta- and zeta-tubulin families; The tubulin superfamily includes five distinct families, ...
 1-97 3.48e-22

The delta- and zeta-tubulin families; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The alpha- and beta-tubulins are the major components of microtubules, while gamma-tubulin plays a major role in the nucleation of microtubule assembly. The delta- and epsilon-tubulins are widespread but unlike the alpha, beta, and gamma-tubulins they are not ubiquitous among eukaryotes. Delta-tubulin plays an essential role in forming the triplet microtubules of centrioles and basal bodies.


Pssm-ID: 276958 [Multi-domain]  Cd Length: 433  Bit Score: 88.48  E-value: 3.48e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671706948   1 GNQIGAAFWQTISGEhgLDGSGvyngSSDLQLERMNVYFNEASNNKYVPRAVLVDLEPGTMDAVRAGPFGQL--FRPDNF 78
Cdd:cd02189   11 GNQLGDELFDTLADE--ADSSA----SEGDQNSSATRFFSPFSDGKLKARCVLVDMEPKVVQQVLSRARSGAwsYDPKNV 84

                         90
                 ....*....|....*....
gi 671706948  79 VFGQSGAGNNWAKGHYTEG 97
Cdd:cd02189   85 VCGQSGSGNNWALGYYVHG 103
epsilon_tubulin cd02190
The epsilon-tubulin family; The tubulin superfamily includes five distinct families, the ...
 1-97 2.03e-20

The epsilon-tubulin family; The tubulin superfamily includes five distinct families, the alpha-, beta-, gamma-, delta-, and epsilon-tubulins and a sixth family (zeta-tubulin) which is present only in kinetoplastid protozoa. The epsilon-tubulins which are widespread but not ubiquitous among eukaryotes play a role in basal body/centriole morphogenesis.


Pssm-ID: 276959 [Multi-domain]  Cd Length: 449  Bit Score: 83.83  E-value: 2.03e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671706948   1 GNQIGAAFWQTISGEHG-LDGSGVYNgssdlqlERMNVYF-------NEASNNKYVP------RAVLVDLEPGTMDAVRA 66
Cdd:cd02190   12 GNQIGCRFWDLALREHAaYNKDGVYD-------DSMSSFFrnvdtrsGDPGDDGGSPikslkaRAVLIDMEEGVVNELLK 84

                         90       100       110
                 ....*....|....*....|....*....|.
gi 671706948  67 GPFGQLFRPDNFVFGQSGAGNNWAKGHYTEG 97
Cdd:cd02190   85 GPLGDLFDETQLVTDVSGAGNNWAHGYHEYG 115
Tubulin smart00864
Tubulin/FtsZ family, GTPase domain; This domain is found in all tubulin chains, as well as the ...
 36-97 2.11e-20

Tubulin/FtsZ family, GTPase domain; This domain is found in all tubulin chains, as well as the bacterial FtsZ family of proteins. These proteins are involved in polymer formation. Tubulin is the major component of microtubules, while FtsZ is the polymer-forming protein of bacterial cell division, it is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ and tubulin are GTPases, this entry is the GTPase domain. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in bacteria and archaea.


Pssm-ID: 214867 [Multi-domain]  Cd Length: 192  Bit Score: 80.61  E-value: 2.11e-20
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 671706948    36 NVYFNEasnNKYVPRAVLVDLEPGTMDAVRAGPFGQLFRPDNFVFGQSGAGNNWAKGHYTEG 97
Cdd:smart00864   2 IKVFGV---GGGGPNAVNVDLEPGVIDGVRANTDAQALNPESLASGKIQAGNNWTRGLGAGA 60
PTZ00387 PTZ00387
epsilon tubulin; Provisional
 1-97 1.11e-19

epsilon tubulin; Provisional


Pssm-ID: 240395 [Multi-domain]  Cd Length: 465  Bit Score: 81.69  E-value: 1.11e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671706948   1 GNQIGAAFWQTISGEH-GLDGSGVYNGSSDLQLERMNVYFNEASNNKYVPRAVLVDLEPGTMDAVRAGPFGQLFRPDNFV 79
Cdd:PTZ00387  13 GNQLGHRFWDVALKEHkKINANPQYDDARDSFFENVSENVNRPGKENLKARAVLVDMEEGVLNQILKSPLGDLFDENFFV 92

                         90
                 ....*....|....*...
gi 671706948  80 FGQSGAGNNWAKGHYTEG 97
Cdd:PTZ00387  93 SDVSGAGNNWAVGHMEYG 110
Tubulin_FtsZ_Cetz-like cd00286
Tubulin protein family of FtsZ and CetZ-like; This family includes tubulin alpha-, beta-, ...
 1-97 1.01e-15

Tubulin protein family of FtsZ and CetZ-like; This family includes tubulin alpha-, beta-, gamma-, delta-, epsilon, and zeta-tubulins as well as FtsZ and CetZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved oligomer. Microtubules exist in all eukaryotic cells and are responsible for many functions, including cellular transport, cell motility, and mitosis. FtsZ forms a ring-shaped septum at the site of bacterial cell division, which is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ can polymerize into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria, archaea, and chloroplasts. A recent study found that CetZ proteins, formerly annotated FtsZ type 2, are not required for cell division, whereas FtsZ proteins play an important role. Instead, CetZ proteins are shown to be involved in controlling archaeal cell shape dynamics. The results from inactivation studies of CetZ proteins in Haloferax volcanii suggest that CetZ1 is essential for normal swimming motility and rod-cell development.


Pssm-ID: 276954 [Multi-domain]  Cd Length: 332  Bit Score: 70.13  E-value: 1.01e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 671706948   1 GNQIGAAFWQtisgehgldgsgvyngssdlqlermnvyfneasnnkyvpRAVLVDLEPGTMDAVRAGPFGQLFRPDNFVF 80
Cdd:cd00286   11 GNQIGAAFWE---------------------------------------QAVLVDLEPAVLDELLSGPLRQLFHPENIIL 51

                         90
                 ....*....|....*....
gi 671706948  81 GQS--GAGNNWAKGHYTEG 97
Cdd:cd00286   52 IQKyhGAGNNWAKGHSVAG 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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