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Conserved domains on  [gi|627792146|gb|AHY61175|]
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DENN domain-containing protein 5B, partial [Galagoides demidoff]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLAT super family cl00011
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 1-48 5.63e-26

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


The actual alignment was detected with superfamily member cd01757:

Pssm-ID: 412108  Cd Length: 114  Bit Score: 90.29  E-value: 5.63e-26
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 627792146   1 KLGGSMFTANPWICISGELGETQILQIPRNVLEMTFECQNLGKLTTVQ 48
Cdd:cd01757   12 KLGGSMFTANPWICVSGELGETPPLQIPKNSLEMTFDCQNLGKLTTVQ 59
 
Name Accession Description Interval E-value
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
 1-48 5.63e-26

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 90.29  E-value: 5.63e-26
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 627792146   1 KLGGSMFTANPWICISGELGETQILQIPRNVLEMTFECQNLGKLTTVQ 48
Cdd:cd01757   12 KLGGSMFTANPWICVSGELGETPPLQIPKNSLEMTFDCQNLGKLTTVQ 59
 
Name Accession Description Interval E-value
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
 1-48 5.63e-26

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 90.29  E-value: 5.63e-26
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 627792146   1 KLGGSMFTANPWICISGELGETQILQIPRNVLEMTFECQNLGKLTTVQ 48
Cdd:cd01757   12 KLGGSMFTANPWICVSGELGETPPLQIPKNSLEMTFDCQNLGKLTTVQ 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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