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Conserved domains on  [gi|589068878|gb|AHK33737|]
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putative abhydrolase domain-containing protein [Rhodococcus opacus PD630]

Protein Classification

alpha/beta hydrolase( domain architecture ID 12114401)

alpha/beta hydrolase family protein catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

CATH:  3.40.50.1820
EC:  3.-.-.-
Gene Ontology:  GO:0016787
PubMed:  12369917|19508187|37582413

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 27-261 4.61e-86

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


:

Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 256.76  E-value: 4.61e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878   27 PRGVLVLCHGFGEHARRYDHVIERLGELDLAIYAPDHRGHGRSGGKRVHLKDWSEFTDDLHQLFGIASTDWPGTDRFLLG 106
Cdd:pfam12146   3 PRAVVVLVHGLGEHSGRYAHLADALAAQGFAVYAYDHRGHGRSDGKRGHVPSFDDYVDDLDTFVDKIREEHPGLPLFLLG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878  107 HSMGGSIALTYALDHQQDLKALMLSGPAVDVTSGT-PRVVVEIGKLVGRFLPGVPVES-LDAKLVSRDPAVVSAYEEDPL 184
Cdd:pfam12146  83 HSMGGLIAALYALRYPDKVDGLILSAPALKIKPYLaPPILKLLAKLLGKLFPRLRVPNnLLPDSLSRDPEVVAAYAADPL 162

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 589068878  185 VhHGKVPAGIARGMILAAERLPERLPSLTVPLLLQHGQDDGLASVHGTELIAEYVGSEDLTVEIYENLFHEVFNEPE 261
Cdd:pfam12146 163 V-HGGISARTLYELLDAGERLLRRAAAITVPLLLLHGGADRVVDPAGSREFYERAGSTDKTLKLYPGLYHELLNEPD 238
 
Name Accession Description Interval E-value
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 27-261 4.61e-86

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 256.76  E-value: 4.61e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878   27 PRGVLVLCHGFGEHARRYDHVIERLGELDLAIYAPDHRGHGRSGGKRVHLKDWSEFTDDLHQLFGIASTDWPGTDRFLLG 106
Cdd:pfam12146   3 PRAVVVLVHGLGEHSGRYAHLADALAAQGFAVYAYDHRGHGRSDGKRGHVPSFDDYVDDLDTFVDKIREEHPGLPLFLLG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878  107 HSMGGSIALTYALDHQQDLKALMLSGPAVDVTSGT-PRVVVEIGKLVGRFLPGVPVES-LDAKLVSRDPAVVSAYEEDPL 184
Cdd:pfam12146  83 HSMGGLIAALYALRYPDKVDGLILSAPALKIKPYLaPPILKLLAKLLGKLFPRLRVPNnLLPDSLSRDPEVVAAYAADPL 162

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 589068878  185 VhHGKVPAGIARGMILAAERLPERLPSLTVPLLLQHGQDDGLASVHGTELIAEYVGSEDLTVEIYENLFHEVFNEPE 261
Cdd:pfam12146 163 V-HGGISARTLYELLDAGERLLRRAAAITVPLLLLHGGADRVVDPAGSREFYERAGSTDKTLKLYPGLYHELLNEPD 238
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
1-274 2.13e-59

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 188.29  E-value: 2.13e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878   1 MQHRESSFAGVGGIPIVYDVWLPERRPRGVLVLCHGFGEHARRYDHVIERLGELDLAIYAPDHRGHGRSGGKRVHLKDWS 80
Cdd:COG2267    1 MTRRLVTLPTRDGLRLRGRRWRPAGSPRGTVVLVHGLGEHSGRYAELAEALAAAGYAVLAFDLRGHGRSDGPRGHVDSFD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878  81 EFTDDLHQLFGIASTDwPGTDRFLLGHSMGGSIALTYALDHQQDLKALMLSGPavdvtsgtprvvveigklvgrflpgvp 160
Cdd:COG2267   81 DYVDDLRAALDALRAR-PGLPVVLLGHSMGGLIALLYAARYPDRVAGLVLLAP--------------------------- 132

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878 161 vesldaklvsrdpavvsAYEEDPLVHhgkVPAGIARGMilaaeRLPERLPSLTVPLLLQHGQDDGLASVHGTELIAEYVg 240
Cdd:COG2267  133 -----------------AYRADPLLG---PSARWLRAL-----RLAEALARIDVPVLVLHGGADRVVPPEAARRLAARL- 186

                        250       260       270
                 ....*....|....*....|....*....|....
gi 589068878 241 SEDLTVEIYENLFHEVFNEPENEEVLDDLVEWLR 274
Cdd:COG2267  187 SPDVELVLLPGARHELLNEPAREEVLAAILAWLE 220
PHA02857 PHA02857
monoglyceride lipase; Provisional
 8-278 1.91e-45

monoglyceride lipase; Provisional


Pssm-ID: 165193 [Multi-domain]  Cd Length: 276  Bit Score: 154.27  E-value: 1.91e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878   8 FAGVGGIPIVYDVWLPERRPRGVLVLCHGFGEHARRYDHVIERLGELDLAIYAPDHRGHGRSGGKRVHLKDWSEFTDDLH 87
Cdd:PHA02857   5 MFNLDNDYIYCKYWKPITYPKALVFISHGAGEHSGRYEELAENISSLGILVFSHDHIGHGRSNGEKMMIDDFGVYVRDVV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878  88 QLFGIASTDWPGTDRFLLGHSMGGSIALTYALDHQQDLKALMLSGPAVDvTSGTPRVVVEIGKLVGRFLPGVPVESLDAK 167
Cdd:PHA02857  85 QHVVTIKSTYPGVPVFLLGHSMGATISILAAYKNPNLFTAMILMSPLVN-AEAVPRLNLLAAKLMGIFYPNKIVGKLCPE 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878 168 LVSRDPAVVSAYEEDPLVHHGKVPAGIARGMILAAERLPERLPSLTVPLLLQHGQDDGLASVHGTELIAEYVGSeDLTVE 247
Cdd:PHA02857 164 SVSRDMDEVYKYQYDPLVNHEKIKAGFASQVLKATNKVRKIIPKIKTPILILQGTNNEISDVSGAYYFMQHANC-NREIK 242

                        250       260       270
                 ....*....|....*....|....*....|...
gi 589068878 248 IYENLFHEVFNEPEN--EEVLDDLVEWLRPRVQ 278
Cdd:PHA02857 243 IYEGAKHHLHKETDEvkKSVMKEIETWIFNRVK 275
PST-A TIGR01607
Plasmodium subtelomeric family (PST-A); This model represents a paralogous family of genes in ...
 29-274 4.07e-14

Plasmodium subtelomeric family (PST-A); This model represents a paralogous family of genes in Plasmodium falciparum and Plasmodium yoelii, which are closely related to various phospholipases and lysophospholipases of plants as well as generally being related to the alpha/beta-fold superfamily of hydrolases. These genes are preferentially located in the subtelomeric regions of the chromosomes of both P. falciparum and P. yoelii.


Pssm-ID: 162444 [Multi-domain]  Cd Length: 332  Bit Score: 71.35  E-value: 4.07e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878   29 GVLVLCHGFGEHAR----------------------RY----DHVIERLGELDLAIYAPDHRGHGRSGGK---RVHLKDW 79
Cdd:TIGR01607  22 GIIVLIHGLKSHLRlqflkinakivnndravlidtdNYyiykDSWIENFNKNGYSVYGLDLQGHGESDGLqnlRGHINCF 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878   80 SEFTDDLHQL--------------------FGIASTDWPGTDRFLLGHSMGGSIAL--------TYALDHQQDLKALM-L 130
Cdd:TIGR01607 102 DDLVYDVIQYmnrindsiilenetksddesYDIVNTKENRLPMYIIGLSMGGNIALrllellgkSNENNDKLNIKGCIsL 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878  131 SGPAVDVTSGTP------RVVVEIGKLVGRFLPGVPVESldAKLVSRDPAVVSAYEEDPLVHHGKVPAGIARGMILAAER 204
Cdd:TIGR01607 182 SGMISIKSVGSDdsfkfkYFYLPVMNFMSRVFPTFRISK--KIRYEKSPYVNDIIKFDKFRYDGGITFNLASELIKATDT 259

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 589068878  205 LP---ERLPSlTVPLLLQHGQDDGLASVHGTELIAEYVGSEDLTVEIYENLFHEVFNEPENEEVLDDLVEWLR 274
Cdd:TIGR01607 260 LDcdiDYIPK-DIPILFIHSKGDCVCSYEGTVSFYNKLSISNKELHTLEDMDHVITIEPGNEEVLKKIIEWIS 331
 
Name Accession Description Interval E-value
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 27-261 4.61e-86

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 256.76  E-value: 4.61e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878   27 PRGVLVLCHGFGEHARRYDHVIERLGELDLAIYAPDHRGHGRSGGKRVHLKDWSEFTDDLHQLFGIASTDWPGTDRFLLG 106
Cdd:pfam12146   3 PRAVVVLVHGLGEHSGRYAHLADALAAQGFAVYAYDHRGHGRSDGKRGHVPSFDDYVDDLDTFVDKIREEHPGLPLFLLG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878  107 HSMGGSIALTYALDHQQDLKALMLSGPAVDVTSGT-PRVVVEIGKLVGRFLPGVPVES-LDAKLVSRDPAVVSAYEEDPL 184
Cdd:pfam12146  83 HSMGGLIAALYALRYPDKVDGLILSAPALKIKPYLaPPILKLLAKLLGKLFPRLRVPNnLLPDSLSRDPEVVAAYAADPL 162

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 589068878  185 VhHGKVPAGIARGMILAAERLPERLPSLTVPLLLQHGQDDGLASVHGTELIAEYVGSEDLTVEIYENLFHEVFNEPE 261
Cdd:pfam12146 163 V-HGGISARTLYELLDAGERLLRRAAAITVPLLLLHGGADRVVDPAGSREFYERAGSTDKTLKLYPGLYHELLNEPD 238
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
1-274 2.13e-59

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 188.29  E-value: 2.13e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878   1 MQHRESSFAGVGGIPIVYDVWLPERRPRGVLVLCHGFGEHARRYDHVIERLGELDLAIYAPDHRGHGRSGGKRVHLKDWS 80
Cdd:COG2267    1 MTRRLVTLPTRDGLRLRGRRWRPAGSPRGTVVLVHGLGEHSGRYAELAEALAAAGYAVLAFDLRGHGRSDGPRGHVDSFD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878  81 EFTDDLHQLFGIASTDwPGTDRFLLGHSMGGSIALTYALDHQQDLKALMLSGPavdvtsgtprvvveigklvgrflpgvp 160
Cdd:COG2267   81 DYVDDLRAALDALRAR-PGLPVVLLGHSMGGLIALLYAARYPDRVAGLVLLAP--------------------------- 132

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878 161 vesldaklvsrdpavvsAYEEDPLVHhgkVPAGIARGMilaaeRLPERLPSLTVPLLLQHGQDDGLASVHGTELIAEYVg 240
Cdd:COG2267  133 -----------------AYRADPLLG---PSARWLRAL-----RLAEALARIDVPVLVLHGGADRVVPPEAARRLAARL- 186

                        250       260       270
                 ....*....|....*....|....*....|....
gi 589068878 241 SEDLTVEIYENLFHEVFNEPENEEVLDDLVEWLR 274
Cdd:COG2267  187 SPDVELVLLPGARHELLNEPAREEVLAAILAWLE 220
PHA02857 PHA02857
monoglyceride lipase; Provisional
 8-278 1.91e-45

monoglyceride lipase; Provisional


Pssm-ID: 165193 [Multi-domain]  Cd Length: 276  Bit Score: 154.27  E-value: 1.91e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878   8 FAGVGGIPIVYDVWLPERRPRGVLVLCHGFGEHARRYDHVIERLGELDLAIYAPDHRGHGRSGGKRVHLKDWSEFTDDLH 87
Cdd:PHA02857   5 MFNLDNDYIYCKYWKPITYPKALVFISHGAGEHSGRYEELAENISSLGILVFSHDHIGHGRSNGEKMMIDDFGVYVRDVV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878  88 QLFGIASTDWPGTDRFLLGHSMGGSIALTYALDHQQDLKALMLSGPAVDvTSGTPRVVVEIGKLVGRFLPGVPVESLDAK 167
Cdd:PHA02857  85 QHVVTIKSTYPGVPVFLLGHSMGATISILAAYKNPNLFTAMILMSPLVN-AEAVPRLNLLAAKLMGIFYPNKIVGKLCPE 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878 168 LVSRDPAVVSAYEEDPLVHHGKVPAGIARGMILAAERLPERLPSLTVPLLLQHGQDDGLASVHGTELIAEYVGSeDLTVE 247
Cdd:PHA02857 164 SVSRDMDEVYKYQYDPLVNHEKIKAGFASQVLKATNKVRKIIPKIKTPILILQGTNNEISDVSGAYYFMQHANC-NREIK 242

                        250       260       270
                 ....*....|....*....|....*....|...
gi 589068878 248 IYENLFHEVFNEPEN--EEVLDDLVEWLRPRVQ 278
Cdd:PHA02857 243 IYEGAKHHLHKETDEvkKSVMKEIETWIFNRVK 275
PLN02652 PLN02652
hydrolase; alpha/beta fold family protein
 20-277 6.25e-28

hydrolase; alpha/beta fold family protein


Pssm-ID: 215352 [Multi-domain]  Cd Length: 395  Bit Score: 110.75  E-value: 6.25e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878  20 VWLP-ERRPRGVLVLCHGFGEHARRYDHVIERLGELDLAIYAPDHRGHGRSGGKRVHLKDWSEFTDDLHQLFGIASTDWP 98
Cdd:PLN02652 127 SWAPaAGEMRGILIIIHGLNEHSGRYLHFAKQLTSCGFGVYAMDWIGHGGSDGLHGYVPSLDYVVEDTEAFLEKIRSENP 206

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878  99 GTDRFLLGHSMGGSIALTYAL--DHQQDLKALMLSGPAVDVTSGTPRV--VVEIGKLV-------GRFLPGVPvesldak 167
Cdd:PLN02652 207 GVPCFLFGHSTGGAVVLKAASypSIEDKLEGIVLTSPALRVKPAHPIVgaVAPIFSLVaprfqfkGANKRGIP------- 279

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878 168 lVSRDPAVVSAYEEDPLVHHGKVPAGIARGMILAAERLPERLPSLTVPLLLQHGQDDGLASVHGTELIAEYVGSEDLTVE 247
Cdd:PLN02652 280 -VSRDPAALLAKYSDPLVYTGPIRVRTGHEILRISSYLTRNFKSVTVPFMVLHGTADRVTDPLASQDLYNEAASRHKDIK 358

                        250       260       270
                 ....*....|....*....|....*....|
gi 589068878 248 IYENLFHEVFNEPENEEVLDDLVEWLRPRV 277
Cdd:PLN02652 359 LYDGFLHDLLFEPEREEVGRDIIDWMEKRL 388
PLN02298 PLN02298
hydrolase, alpha/beta fold family protein
 3-279 4.63e-26

hydrolase, alpha/beta fold family protein


Pssm-ID: 165939 [Multi-domain]  Cd Length: 330  Bit Score: 104.47  E-value: 4.63e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878   3 HRESSFAGVGGIPIVYDVWLPERR--PRGVLVLCHGFGEHAR-RYDHVIERLGELDLAIYAPDHRGHGRSGGKRVHLKDW 79
Cdd:PLN02298  32 GSKSFFTSPRGLSLFTRSWLPSSSspPRALIFMVHGYGNDISwTFQSTAIFLAQMGFACFALDLEGHGRSEGLRAYVPNV 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878  80 SEFTDDLHQLFGIASTDWP--GTDRFLLGHSMGGSIALTYALDHQQDLKALMLSGPAVDVTSGT--PRVVVEIGKLVGRF 155
Cdd:PLN02298 112 DLVVEDCLSFFNSVKQREEfqGLPRFLYGESMGGAICLLIHLANPEGFDGAVLVAPMCKISDKIrpPWPIPQILTFVARF 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878 156 LPG---VPVESLDAKLVsRDPAVVSAYEEDPLVHHGKVPAGIARGMILAAERLPERLPSLTVPLLLQHGQDDGLASVHGT 232
Cdd:PLN02298 192 LPTlaiVPTADLLEKSV-KVPAKKIIAKRNPMRYNGKPRLGTVVELLRVTDYLGKKLKDVSIPFIVLHGSADVVTDPDVS 270

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 589068878 233 ELIAEYVGSEDLTVEIYENLFHE-VFNEP-EN-EEVLDDLVEWLRPRVQA 279
Cdd:PLN02298 271 RALYEEAKSEDKTIKIYDGMMHSlLFGEPdENiEIVRRDILSWLNERCTG 320
PLN02385 PLN02385
hydrolase; alpha/beta fold family protein
 13-273 1.64e-23

hydrolase; alpha/beta fold family protein


Pssm-ID: 215216 [Multi-domain]  Cd Length: 349  Bit Score: 97.90  E-value: 1.64e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878  13 GIPIVYDVWLPER-RPRGVLVLCHGFGEHARRY-DHVIERLGELDLAIYAPDHRGHGRSGGKRVHLKDWSEFTDDLHQLF 90
Cdd:PLN02385  71 GVEIFSKSWLPENsRPKAAVCFCHGYGDTCTFFfEGIARKIASSGYGVFAMDYPGFGLSEGLHGYIPSFDDLVDDVIEHY 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878  91 G--IASTDWPGTDRFLLGHSMGGSIALTYALDHQQDLKALMLSGP----AVDVTSgtPRVVVEIGKLVGRFLPG---VPV 161
Cdd:PLN02385 151 SkiKGNPEFRGLPSFLFGQSMGGAVALKVHLKQPNAWDGAILVAPmckiADDVVP--PPLVLQILILLANLLPKaklVPQ 228

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878 162 ESLdAKLVSRDPAVVSAYEEDPLVHHGKVPAGIARGMILAAERLPERLPSLTVPLLLQHGQDDGLASVHGTELIAEYVGS 241
Cdd:PLN02385 229 KDL-AELAFRDLKKRKMAEYNVIAYKDKPRLRTAVELLRTTQEIEMQLEEVSLPLLILHGEADKVTDPSVSKFLYEKASS 307

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 589068878 242 EDLTVEIYENLFHEVFN-EPENE--EVLDDLVEWL 273
Cdd:PLN02385 308 SDKKLKLYEDAYHSILEgEPDEMifQVLDDIISWL 342
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
24-274 3.67e-23

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 95.01  E-value: 3.67e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878  24 ERRPRGVLvLCHGFGEHARRYDHVIERLGELDLAIYAPDHRGHGRSGG--KRVHLKDWsefTDDLHQLFGIASTDWpgtD 101
Cdd:COG1647   12 EGGRKGVL-LLHGFTGSPAEMRPLAEALAKAGYTVYAPRLPGHGTSPEdlLKTTWEDW---LEDVEEAYEILKAGY---D 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878 102 R-FLLGHSMGGSIALTYALDHQqDLKALMLSGPAVDVTSGTPRVVvEIGKLVGRFLPGVPVESLDaklvsrdpavvsayE 180
Cdd:COG1647   85 KvIVIGLSMGGLLALLLAARYP-DVAGLVLLSPALKIDDPSAPLL-PLLKYLARSLRGIGSDIED--------------P 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878 181 EDPLVHHGKVPAGIARGMILAAERLPERLPSLTVPLLLQHGQDDGLASVHGTELIAEYVGSEDLTVEIYENLFHEVFNEP 260
Cdd:COG1647  149 EVAEYAYDRTPLRALAELQRLIREVRRDLPKITAPTLIIQSRKDEVVPPESARYIYERLGSPDKELVWLEDSGHVITLDK 228

                        250
                 ....*....|....
gi 589068878 261 ENEEVLDDLVEWLR 274
Cdd:COG1647  229 DREEVAEEILDFLE 242
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 4-274 1.24e-22

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 92.76  E-value: 1.24e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878   4 RESSFAGVGGIPIVYDVWLPERRPrgvLVLCHGFGEHARRYDHVIERLGElDLAIYAPDHRGHGRSGGKRVHLkDWSEFT 83
Cdd:COG0596    2 STPRFVTVDGVRLHYREAGPDGPP---VVLLHGLPGSSYEWRPLIPALAA-GYRVIAPDLRGHGRSDKPAGGY-TLDDLA 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878  84 DDLHQLFgiastDWPGTDRF-LLGHSMGGSIALTYALDHQQDLKALMLSGPAVDvtsgtprvvveigklvgrflpgvpve 162
Cdd:COG0596   77 DDLAALL-----DALGLERVvLVGHSMGGMVALELAARHPERVAGLVLVDEVLA-------------------------- 125

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878 163 sldaklvsrdpavvsaYEEDPLVHHGKVPAGIARGM-ILAAERLPERLPSLTVPLLLQHGQDDGLASVHGTELIAEYVgs 241
Cdd:COG0596  126 ----------------ALAEPLRRPGLAPEALAALLrALARTDLRERLARITVPTLVIWGEKDPIVPPALARRLAELL-- 187

                        250       260       270
                 ....*....|....*....|....*....|...
gi 589068878 242 EDLTVEIYENLFHEVFNEpENEEVLDDLVEWLR 274
Cdd:COG0596  188 PNAELVVLPGAGHFPPLE-QPEAFAAALRDFLA 219
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 1-274 2.19e-18

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 82.27  E-value: 2.19e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878   1 MQHRESSFAGVGGIPIVYDVWLP--ERRPRGVLVLCHGFGEHARRYDHVIERLGELDLAIYAPDHRGHGRSGGKRVHL-- 76
Cdd:COG1073    8 VNKEDVTFKSRDGIKLAGDLYLPagASKKYPAVVVAHGNGGVKEQRALYAQRLAELGFNVLAFDYRGYGESEGEPREEgs 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878  77 ---KDWSEFTDDLHQLFGIastdwPGTDRFLLGHSMGGSIALTYALDHQQdLKALMLSGPAVDVTS-GTPRVVVEIGKLV 152
Cdd:COG1073   88 perRDARAAVDYLRTLPGV-----DPERIGLLGISLGGGYALNAAATDPR-VKAVILDSPFTSLEDlAAQRAKEARGAYL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878 153 GR--FLPGVPVESLDAKLVsrdpavvsayeeDPLvhhgkvpagiargmilaaerlpERLPSLTVPLLLQHGQDDGLASVH 230
Cdd:COG1073  162 PGvpYLPNVRLASLLNDEF------------DPL----------------------AKIEKISRPLLFIHGEKDEAVPFY 207

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 589068878 231 GTELIAEYVgSEDLTVEIYENLFHEVFNEPENEEVLDDLVEWLR 274
Cdd:COG1073  208 MSEDLYEAA-AEPKELLIVPGAGHVDLYDRPEEEYFDKLAEFFK 250
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 29-257 2.53e-17

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 79.09  E-value: 2.53e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878   29 GVLVLCHGFGEHARRYDHVIERLGELDLAIYAPDHRGHGRSGG----KRVHLKDWSEFTDDLHQLFGIastdwpgTDRFL 104
Cdd:pfam00561   1 PPVLLLHGLPGSSDLWRKLAPALARDGFRVIALDLRGFGKSSRpkaqDDYRTDDLAEDLEYILEALGL-------EKVNL 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878  105 LGHSMGGSIALTYALDHQQDLKALMLSGPaVDVTSGTPRVVVEIGKLVGRFLPGVP------------------VESLDA 166
Cdd:pfam00561  74 VGHSMGGLIALAYAAKYPDRVKALVLLGA-LDPPHELDEADRFILALFPGFFDGFVadfapnplgrlvakllalLLLRLR 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878  167 KLVSRDPAVVSAYEEDPLVHHGKVPAGIARGMILAAERLPERLPSLTVPLLLQHGQDDGLASVHGTELIAEYVGSEdlTV 246
Cdd:pfam00561 153 LLKALPLLNKRFPSGDYALAKSLVTGALLFIETWSTELRAKFLGRLDEPTLIIWGDQDPLVPPQALEKLAQLFPNA--RL 230

                         250
                  ....*....|.
gi 589068878  247 EIYENLFHEVF 257
Cdd:pfam00561 231 VVIPDAGHFAF 241
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
7-274 6.90e-15

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 71.97  E-value: 6.90e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878   7 SFAGVGGIPIVYDVWLPER-RPRGVLVLCHGFGEHA-RRYDHVIERLGELDLAIYAPDHRGHGRSGGK--RVHLKDWSEF 82
Cdd:COG1506    1 TFKSADGTTLPGWLYLPADgKKYPVVVYVHGGPGSRdDSFLPLAQALASRGYAVLAPDYRGYGESAGDwgGDEVDDVLAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878  83 TDDLhqlfgiASTDWPGTDR-FLLGHSMGGSIALTYALDHQQDLKALMLSGPAVDVTSgtprvVVEIGKLVGRFLPGVPV 161
Cdd:COG1506   81 IDYL------AARPYVDPDRiGIYGHSYGGYMALLAAARHPDRFKAAVALAGVSDLRS-----YYGTTREYTERLMGGPW 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878 162 ESLDaklvsrdpavvsAYEEDPLVHHgkvpagiargmilaaerlperLPSLTVPLLLQHGQDDGLASVHGTELIAEYVGS 241
Cdd:COG1506  150 EDPE------------AYAARSPLAY---------------------ADKLKTPLLLIHGEADDRVPPEQAERLYEALKK 196

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 589068878 242 EDLTVE--IYENLFHEvFNEPENEEVLDDLVEWLR 274
Cdd:COG1506  197 AGKPVEllVYPGEGHG-FSGAGAPDYLERILDFLD 230
PRK10749 PRK10749
lysophospholipase L2; Provisional
 2-133 1.56e-14

lysophospholipase L2; Provisional


Pssm-ID: 182697  Cd Length: 330  Bit Score: 72.34  E-value: 1.56e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878   2 QHRESSFAGVGGIPIVYDVWLPERRPRgVLVLCHGFGEHARRYDHVIERLGELDLAIYAPDHRGHGRSG-----GKRVHL 76
Cdd:PRK10749  29 QREEAEFTGVDDIPIRFVRFRAPHHDR-VVVICPGRIESYVKYAELAYDLFHLGYDVLIIDHRGQGRSGrllddPHRGHV 107

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 589068878  77 KDWSEFTDDLHQLFG--IASTDWpgTDRFLLGHSMGGSIALTYALDHQQDLKALMLSGP 133
Cdd:PRK10749 108 ERFNDYVDDLAAFWQqeIQPGPY--RKRYALAHSMGGAILTLFLQRHPGVFDAIALCAP 164
PST-A TIGR01607
Plasmodium subtelomeric family (PST-A); This model represents a paralogous family of genes in ...
 29-274 4.07e-14

Plasmodium subtelomeric family (PST-A); This model represents a paralogous family of genes in Plasmodium falciparum and Plasmodium yoelii, which are closely related to various phospholipases and lysophospholipases of plants as well as generally being related to the alpha/beta-fold superfamily of hydrolases. These genes are preferentially located in the subtelomeric regions of the chromosomes of both P. falciparum and P. yoelii.


Pssm-ID: 162444 [Multi-domain]  Cd Length: 332  Bit Score: 71.35  E-value: 4.07e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878   29 GVLVLCHGFGEHAR----------------------RY----DHVIERLGELDLAIYAPDHRGHGRSGGK---RVHLKDW 79
Cdd:TIGR01607  22 GIIVLIHGLKSHLRlqflkinakivnndravlidtdNYyiykDSWIENFNKNGYSVYGLDLQGHGESDGLqnlRGHINCF 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878   80 SEFTDDLHQL--------------------FGIASTDWPGTDRFLLGHSMGGSIAL--------TYALDHQQDLKALM-L 130
Cdd:TIGR01607 102 DDLVYDVIQYmnrindsiilenetksddesYDIVNTKENRLPMYIIGLSMGGNIALrllellgkSNENNDKLNIKGCIsL 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878  131 SGPAVDVTSGTP------RVVVEIGKLVGRFLPGVPVESldAKLVSRDPAVVSAYEEDPLVHHGKVPAGIARGMILAAER 204
Cdd:TIGR01607 182 SGMISIKSVGSDdsfkfkYFYLPVMNFMSRVFPTFRISK--KIRYEKSPYVNDIIKFDKFRYDGGITFNLASELIKATDT 259

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 589068878  205 LP---ERLPSlTVPLLLQHGQDDGLASVHGTELIAEYVGSEDLTVEIYENLFHEVFNEPENEEVLDDLVEWLR 274
Cdd:TIGR01607 260 LDcdiDYIPK-DIPILFIHSKGDCVCSYEGTVSFYNKLSISNKELHTLEDMDHVITIEPGNEEVLKKIIEWIS 331
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 31-261 5.26e-09

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 55.17  E-value: 5.26e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878   31 LVLCHGFGEHARRydhvIERLGELDLAIYAPDHRGHGRSGGKRVHLKDWSEFTDDLHQLFGiastdwpGTDRFLLGHSMG 110
Cdd:pfam12697   1 VVLVHGAGLSAAP----LAALLAAGVAVLAPDLPGHGSSSPPPLDLADLADLAALLDELGA-------ARPVVLVGHSLG 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878  111 GSIALTYAldhqqdlKALMLSGPAVDVTSGTPRVVVEIGKLVGRFLPGVPVESLDAKlvsRDPAVVSAYEEDPLVHHGKV 190
Cdd:pfam12697  70 GAVALAAA-------AAALVVGVLVAPLAAPPGLLAALLALLARLGAALAAPAWLAA---ESLARGFLDDLPADAEWAAA 139

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 589068878  191 PAGIARGMILAAERLPERLPSLTVPLLLQHGQDDGLASVHGTELIAeyvgSEDLTVEIYENLFHEVFNEPE 261
Cdd:pfam12697 140 LARLAALLAALALLPLAAWRDLPVPVLVLAEEDRLVPELAQRLLAA----LAGARLVVLPGAGHLPLDDPE 206
PRK14875 PRK14875
acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional
 31-134 6.27e-08

acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional


Pssm-ID: 184875 [Multi-domain]  Cd Length: 371  Bit Score: 53.02  E-value: 6.27e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878  31 LVLCHGFGEHARRYDHVIERLGElDLAIYAPDHRGHGRSGgKRVHLKDWSEFTDDLHQL---FGIASTDwpgtdrfLLGH 107
Cdd:PRK14875 134 VVLIHGFGGDLNNWLFNHAALAA-GRPVIALDLPGHGASS-KAVGAGSLDELAAAVLAFldaLGIERAH-------LVGH 204

                         90       100
                 ....*....|....*....|....*..
gi 589068878 108 SMGGSIALTYALDHQQDLKALMLSGPA 134
Cdd:PRK14875 205 SMGGAVALRLAARAPQRVASLTLIAPA 231
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
1-274 2.93e-06

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 47.27  E-value: 2.93e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878   1 MQHRESSFAGVGGIPIVYDVWLPERR-PRGVLVLCHGFGEHARRYDHVIERLGELDLAIYAPDHRGHGRSGG------KR 73
Cdd:COG0412    1 MTTETVTIPTPDGVTLPGYLARPAGGgPRPGVVVLHEIFGLNPHIRDVARRLAAAGYVVLAPDLYGRGGPGDdpdearAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878  74 VHLKDWSEFTDDLHQLFG-IASTDWPGTDRF-LLGHSMGGSIALTYAldhqqdlkalmLSGPAVDvtsgtprvvveigkl 151
Cdd:COG0412   81 MGALDPELLAADLRAALDwLKAQPEVDAGRVgVVGFCFGGGLALLAA-----------ARGPDLA--------------- 134

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878 152 vgrflpgvpvesldaklvsrdpAVVSAYeedplvhhgkvpagiarGMiLAAERLPERLPSLTVPLLLQHGQDDGLASVHG 231
Cdd:COG0412  135 ----------------------AAVSFY-----------------GG-LPADDLLDLAARIKAPVLLLYGEKDPLVPPEQ 174

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 589068878 232 TELIAEYV--GSEDLTVEIYENLFH-------EVFNEPENEEVLDDLVEWLR 274
Cdd:COG0412  175 VAALEAALaaAGVDVELHVYPGAGHgftnpgrPRYDPAAAEDAWQRTLAFLA 226
PRK05855 PRK05855
SDR family oxidoreductase;
1-197 1.26e-05

SDR family oxidoreductase;


Pssm-ID: 235628 [Multi-domain]  Cd Length: 582  Bit Score: 46.13  E-value: 1.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878   1 MQHRESSFAgVGGIPIVYDVWLPERRPrgVLVLCHGFGEHARRYDHVIERLGElDLAIYAPDHRGHGRSGG-KRVHLKDW 79
Cdd:PRK05855   1 SQPRRTVVS-SDGVRLAVYEWGDPDRP--TVVLVHGYPDNHEVWDGVAPLLAD-RFRVVAYDVRGAGRSSApKRTAAYTL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878  80 SEFTDDLHQLFGIAStdwPGTDRFLLGH---SMGGSIALTyaldhQQDLKALM-----LSGPAVD---------VTSGTP 142
Cdd:PRK05855  77 ARLADDFAAVIDAVS---PDRPVHLLAHdwgSIQGWEAVT-----RPRAAGRIasftsVSGPSLDhvgfwlrsgLRRPTP 148

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 589068878 143 RvvvEIGKLVGRF----------LPGVPVESLDAKLVSRDPAVVSAYEEDPLV--HHGKVPAGIARG 197
Cdd:PRK05855 149 R---RLARALGQLlrswyiylfhLPVLPELLWRLGLGRAWPRLLRRVEGTPVDpiPTQTTLSDGAHG 212
FrmB COG0627
S-formylglutathione hydrolase FrmB [Defense mechanisms];
13-123 1.41e-05

S-formylglutathione hydrolase FrmB [Defense mechanisms];


Pssm-ID: 440392 [Multi-domain]  Cd Length: 249  Bit Score: 45.21  E-value: 1.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878  13 GIPIVYDVWLPE---RRPRGVLVLCHGFG---EHARRYDHVIERLGELDLAIYAPDHrghGRSG-------GKRVHLKDW 79
Cdd:COG0627   15 GREMPVSVYLPPgydGRPLPVLYLLHGLTgthENWTRKTGAQRLAAELGVIVVMPDG---GQASfyvdwtqGPAGHYRWE 91

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 589068878  80 SEFTDDLHQLfgIAS---TDWPGTDRFLLGHSMGGSIALTYALDHQQ 123
Cdd:COG0627   92 TYLTEELPPL--IEAnfpVSADRERRAIAGLSMGGHGALTLALRHPD 136
pro_imino_pep_2 TIGR01250
proline-specific peptidase, Bacillus coagulans-type subfamily; This model describes a ...
 99-166 1.97e-05

proline-specific peptidase, Bacillus coagulans-type subfamily; This model describes a subfamily of the alpha/beta fold family of hydrolases. Characterized members include prolinases (Pro-Xaa dipeptidase, EC 3.4.13.8), prolyl aminopeptidases (EC 3.4.11.5), and a leucyl aminopeptidase


Pssm-ID: 188121 [Multi-domain]  Cd Length: 289  Bit Score: 45.06  E-value: 1.97e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 589068878   99 GTDRF-LLGHSMGGSIALTYALDHQQDLKALMLSGPavdvTSGTPRVVVEIGKLVGRFlpgvPVESLDA 166
Cdd:TIGR01250  95 GLDKFyLLGHSWGGMLAQEYALKYGQHLKGLIISSM----LDSAPEYVKELNRLRKEL----PPEVRAA 155
YpfH COG0400
Predicted esterase [General function prediction only];
24-132 2.04e-05

Predicted esterase [General function prediction only];


Pssm-ID: 440169 [Multi-domain]  Cd Length: 200  Bit Score: 44.51  E-value: 2.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878  24 ERRPRGVLVLCHGFGEHARRYDHVIERLGELDLAIYAPD----HRGHGRS------GGKRVHLKDWSEFTDDLHQLFG-- 91
Cdd:COG0400    1 GGPAAPLVVLLHGYGGDEEDLLPLAPELALPGAAVLAPRapvpEGPGGRAwfdlsfLEGREDEEGLAAAAEALAAFIDel 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 589068878  92 IASTDWPGTDRFLLGHSMGGSIALTYALDHQQDLKALM-LSG 132
Cdd:COG0400   81 EARYGIDPERIVLAGFSQGAAMALSLALRRPELLAGVVaLSG 122
COG4188 COG4188
Predicted dienelactone hydrolase [General function prediction only];
15-118 1.55e-04

Predicted dienelactone hydrolase [General function prediction only];


Pssm-ID: 443342 [Multi-domain]  Cd Length: 326  Bit Score: 42.40  E-value: 1.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878  15 PIVYDVWLPERRPRG--------VLVLCHGFGEHARRYDHVIERLGELDLAIYAPDHRGHGRSG--------GKRVHLKD 78
Cdd:COG4188   41 PLPVDVWYPATAPADapaggpfpLVVLSHGLGGSREGYAYLAEHLASHGYVVAAPDHPGSNAADlsaaldglADALDPEE 120

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 589068878  79 WSEFTDD----LHQLFGIASTDWPGTDRF------LLGHSMGGSIALTYA 118
Cdd:COG4188  121 LWERPLDlsfvLDQLLALNKSDPPLAGRLdldrigVIGHSLGGYTALALA 170
PLN02894 PLN02894
hydrolase, alpha/beta fold family protein
 20-134 1.60e-04

hydrolase, alpha/beta fold family protein


Pssm-ID: 215484 [Multi-domain]  Cd Length: 402  Bit Score: 42.59  E-value: 1.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878  20 VWLPERRPRGVLVLCHGFGEHA----RRYDHVIERLgeldlAIYAPDHRGHGRSG------GKRVHLKDWseFTDDLHQl 89
Cdd:PLN02894  97 VTFDSKEDAPTLVMVHGYGASQgfffRNFDALASRF-----RVIAIDQLGWGGSSrpdftcKSTEETEAW--FIDSFEE- 168

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 589068878  90 fgiastdW---PGTDRF-LLGHSMGGSIALTYALDHQQDLKALMLSGPA 134
Cdd:PLN02894 169 -------WrkaKNLSNFiLLGHSFGGYVAAKYALKHPEHVQHLILVGPA 210
YheT COG0429
Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];
23-128 1.08e-03

Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];


Pssm-ID: 440198 [Multi-domain]  Cd Length: 323  Bit Score: 39.74  E-value: 1.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878  23 PERRPRGVLVLCHGFGEHARRydHVIERLG----ELDLAIYAPDHRGHGR----------SGgkrvhlkdwseFTDDLHQ 88
Cdd:COG0429   56 PPAPSKPLVVLLHGLEGSSDS--HYARGLAralyARGWDVVRLNFRGCGGepnllprlyhSG-----------DTEDLVW 122

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 589068878  89 LFGIASTDWPGTDRFLLGHSMGGSIALTYALDHQQDLKAL 128
Cdd:COG0429  123 VLAHLRARYPYAPLYAVGFSLGGNLLLKYLGEQGDDAPPL 162
PRK11126 PRK11126
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; Provisional
 31-132 1.32e-03

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; Provisional


Pssm-ID: 236855 [Multi-domain]  Cd Length: 242  Bit Score: 39.44  E-value: 1.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878  31 LVLCHGFGEHARRYDHVIERLGE-----LDLAiyapdhrGHGRSggKRVHLKDWSEFTDDLHQLF---GIAstdwpgtDR 102
Cdd:PRK11126   5 LVFLHGLLGSGQDWQPVGEALPDyprlyIDLP-------GHGGS--AAISVDGFADVSRLLSQTLqsyNIL-------PY 68

                         90       100       110
                 ....*....|....*....|....*....|.
gi 589068878 103 FLLGHSMGGSIALTYALDHQ-QDLKALMLSG 132
Cdd:PRK11126  69 WLVGYSLGGRIAMYYACQGLaGGLCGLIVEG 99
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
 23-133 3.08e-03

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 36.35  E-value: 3.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878  23 PERRPrgvLVLCHGFGEHARRYDHVIERLGELDLAIYAPDHrgHGRSGGKRVHLKDWSEFTDDLHQLFGIASTDwpgtdr 102
Cdd:COG1075    3 ATRYP---VVLVHGLGGSAASWAPLAPRLRAAGYPVYALNY--PSTNGSIEDSAEQLAAFVDAVLAATGAEKVD------ 71

                         90       100       110
                 ....*....|....*....|....*....|....
gi 589068878 103 fLLGHSMGGSIALTYA--LDHQQDLKAL-MLSGP 133
Cdd:COG1075   72 -LVGHSMGGLVARYYLkrLGGAAKVARVvTLGTP 104
Fes COG2382
Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];
18-121 3.27e-03

Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];


Pssm-ID: 441948 [Multi-domain]  Cd Length: 314  Bit Score: 38.30  E-value: 3.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878  18 YDVWLP-----ERRPRGVLVLCHGFGEHARRY------DHVIERL---GELDLAIY-APDHRGHGRSGGKRVHLKD-WSE 81
Cdd:COG2382   97 VWVYLPpgydnPGKKYPVLYLLDGGGGDEQDWfdqgrlPTILDNLiaaGKIPPMIVvMPDGGDGGDRGTEGPGNDAfERF 176

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 589068878  82 FTDDL----HQLFGIaSTDwpGTDRFLLGHSMGGSIALTYALDH 121
Cdd:COG2382  177 LAEELipfvEKNYRV-SAD--PEHRAIAGLSMGGLAALYAALRH 217
Axe1 COG3458
Cephalosporin-C deacetylase or related acetyl esterase [Secondary metabolites biosynthesis, ...
 7-134 4.60e-03

Cephalosporin-C deacetylase or related acetyl esterase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 442681 [Multi-domain]  Cd Length: 318  Bit Score: 37.86  E-value: 4.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878   7 SFAGVGGIPIvYDvWLpeRRPRG-----VLVLCHGFGehARRYDhVIERLG--ELDLAIYAPDHRGHGRSGGKRvhlKDW 79
Cdd:COG3458   60 TFTGFGGARI-YG-WL--LRPKGegplpAVVEFHGYG--GGRGL-PHEDLDwaAAGYAVLVMDTRGQGSSWGDT---PDP 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 589068878  80 SEFTDD---LHQLFGIASTD-----------------------WPGTDRFLLGHSMGGSIAL-TYALDhqQDLKALMLSG 132
Cdd:COG3458  130 GGYSGGalpGYMTRGIDDPDtyyyrrvyldavravdalrslpeVDGKRIGVTGGSQGGGLALaAAALD--PRVKAAAADV 207


                 ..
gi 589068878 133 PA 134
Cdd:COG3458  208 PF 209
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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