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Conserved domains on  [gi|572723465|gb|AHF53732|]
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homoserine dehydrogenase, partial [Bradyrhizobium sp. CCBAU 45500]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK06349 super family cl35469
homoserine dehydrogenase; Provisional
 1-160 6.39e-103

homoserine dehydrogenase; Provisional


The actual alignment was detected with superfamily member PRK06349:

Pssm-ID: 235783 [Multi-domain]  Cd Length: 426  Bit Score: 301.22  E-value: 6.39e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572723465   1 KHGLKLAKAAEKHGGALNFEAAVGAAIPVIKTLREGLAGTGVTRVYGILNGTCNYILTRMEQEGLSFAECLKDAQRLGYA 80
Cdd:PRK06349 110 VHGAELFAAAEEKGVDLYFEAAVAGGIPIIKALREGLAANRITRVMGIVNGTTNYILTKMTEEGLSFEDALKEAQRLGYA 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572723465  81 EANPSFDVDGHDTAQKLAILASLAFGTKVAQSAVYVEGISSIAPEDLRAADDLGYRLKLLGVAVRTAKGIEQRVHPTMVP 160
Cdd:PRK06349 190 EADPTFDVEGIDAAHKLAILASLAFGTRVDFDDVYVEGISKITAEDIAYAKELGYRIKLLGIAERTEEGIELRVHPTLIP 269
 
Name Accession Description Interval E-value
PRK06349 PRK06349
homoserine dehydrogenase; Provisional
 1-160 6.39e-103

homoserine dehydrogenase; Provisional


Pssm-ID: 235783 [Multi-domain]  Cd Length: 426  Bit Score: 301.22  E-value: 6.39e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572723465   1 KHGLKLAKAAEKHGGALNFEAAVGAAIPVIKTLREGLAGTGVTRVYGILNGTCNYILTRMEQEGLSFAECLKDAQRLGYA 80
Cdd:PRK06349 110 VHGAELFAAAEEKGVDLYFEAAVAGGIPIIKALREGLAANRITRVMGIVNGTTNYILTKMTEEGLSFEDALKEAQRLGYA 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572723465  81 EANPSFDVDGHDTAQKLAILASLAFGTKVAQSAVYVEGISSIAPEDLRAADDLGYRLKLLGVAVRTAKGIEQRVHPTMVP 160
Cdd:PRK06349 190 EADPTFDVEGIDAAHKLAILASLAFGTRVDFDDVYVEGISKITAEDIAYAKELGYRIKLLGIAERTEEGIELRVHPTLIP 269
ThrA COG0460
Homoserine dehydrogenase [Amino acid transport and metabolism]; Homoserine dehydrogenase is ...
 1-160 8.96e-93

Homoserine dehydrogenase [Amino acid transport and metabolism]; Homoserine dehydrogenase is part of the Pathway/BioSystem: Methionine biosynthesis


Pssm-ID: 440228 [Multi-domain]  Cd Length: 302  Bit Score: 271.15  E-value: 8.96e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572723465   1 KHGLKLAKAAEKHGGALNFEAAVGAAIPVIKTLREGLAGTGVTRVYGILNGTCNYILTRMEQEGLSFAECLKDAQRLGYA 80
Cdd:COG0460   88 EHGKELFELARKNGVDLLFEAAVGGGIPIIKTLRELLAGDRITRIEGILNGTTNYILTKMEEEGLSFSEALKEAQELGYA 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572723465  81 EANPSFDVDGHDTAQKLAILASLAFGTKVAQSAVYVEGISSIAPEDLRAADDLGYRLKLLGVAVRTAKGIEQRVHPTMVP 160
Cdd:COG0460  168 EADPTADVEGIDAARKLAILARLAFGTPVELEDVYVEGITRITAEDIAAAKELGYVIKLLAIAERTGGGVEARVHPTLVP 247
Homoserine_dh pfam00742
Homoserine dehydrogenase;
28-160 2.54e-72

Homoserine dehydrogenase;


Pssm-ID: 459921 [Multi-domain]  Cd Length: 178  Bit Score: 214.93  E-value: 2.54e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572723465   28 PVIKTLREGLAGTGVTRVYGILNGTCNYILTRMEQEGLSFAECLKDAQRLGYAEANPSFDVDGHDTAQKLAILASLAFGT 107
Cdd:pfam00742   1 PIIRTLRLSLAGDRITRIEGILNGTTNYILTRMEEEGLSFSEALKEAQELGYAEADPTDDVEGIDAARKLAILARLAFGL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 572723465  108 KVAQSAVYVEGISSIAPEDLRAADDLGYRLKLLGVAVRTAKGIEQRVHPTMVP 160
Cdd:pfam00742  81 DVELEDVEVEGITRLTAEDIAYAKELGKVIKLVASAKRDDGGVEARVGPTLVP 133
 
Name Accession Description Interval E-value
PRK06349 PRK06349
homoserine dehydrogenase; Provisional
 1-160 6.39e-103

homoserine dehydrogenase; Provisional


Pssm-ID: 235783 [Multi-domain]  Cd Length: 426  Bit Score: 301.22  E-value: 6.39e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572723465   1 KHGLKLAKAAEKHGGALNFEAAVGAAIPVIKTLREGLAGTGVTRVYGILNGTCNYILTRMEQEGLSFAECLKDAQRLGYA 80
Cdd:PRK06349 110 VHGAELFAAAEEKGVDLYFEAAVAGGIPIIKALREGLAANRITRVMGIVNGTTNYILTKMTEEGLSFEDALKEAQRLGYA 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572723465  81 EANPSFDVDGHDTAQKLAILASLAFGTKVAQSAVYVEGISSIAPEDLRAADDLGYRLKLLGVAVRTAKGIEQRVHPTMVP 160
Cdd:PRK06349 190 EADPTFDVEGIDAAHKLAILASLAFGTRVDFDDVYVEGISKITAEDIAYAKELGYRIKLLGIAERTEEGIELRVHPTLIP 269
ThrA COG0460
Homoserine dehydrogenase [Amino acid transport and metabolism]; Homoserine dehydrogenase is ...
 1-160 8.96e-93

Homoserine dehydrogenase [Amino acid transport and metabolism]; Homoserine dehydrogenase is part of the Pathway/BioSystem: Methionine biosynthesis


Pssm-ID: 440228 [Multi-domain]  Cd Length: 302  Bit Score: 271.15  E-value: 8.96e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572723465   1 KHGLKLAKAAEKHGGALNFEAAVGAAIPVIKTLREGLAGTGVTRVYGILNGTCNYILTRMEQEGLSFAECLKDAQRLGYA 80
Cdd:COG0460   88 EHGKELFELARKNGVDLLFEAAVGGGIPIIKTLRELLAGDRITRIEGILNGTTNYILTKMEEEGLSFSEALKEAQELGYA 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572723465  81 EANPSFDVDGHDTAQKLAILASLAFGTKVAQSAVYVEGISSIAPEDLRAADDLGYRLKLLGVAVRTAKGIEQRVHPTMVP 160
Cdd:COG0460  168 EADPTADVEGIDAARKLAILARLAFGTPVELEDVYVEGITRITAEDIAAAKELGYVIKLLAIAERTGGGVEARVHPTLVP 247
Homoserine_dh pfam00742
Homoserine dehydrogenase;
28-160 2.54e-72

Homoserine dehydrogenase;


Pssm-ID: 459921 [Multi-domain]  Cd Length: 178  Bit Score: 214.93  E-value: 2.54e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572723465   28 PVIKTLREGLAGTGVTRVYGILNGTCNYILTRMEQEGLSFAECLKDAQRLGYAEANPSFDVDGHDTAQKLAILASLAFGT 107
Cdd:pfam00742   1 PIIRTLRLSLAGDRITRIEGILNGTTNYILTRMEEEGLSFSEALKEAQELGYAEADPTDDVEGIDAARKLAILARLAFGL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 572723465  108 KVAQSAVYVEGISSIAPEDLRAADDLGYRLKLLGVAVRTAKGIEQRVHPTMVP 160
Cdd:pfam00742  81 DVELEDVEVEGITRLTAEDIAYAKELGKVIKLVASAKRDDGGVEARVGPTLVP 133
PRK06270 PRK06270
homoserine dehydrogenase; Provisional
 6-160 7.25e-61

homoserine dehydrogenase; Provisional


Pssm-ID: 235763 [Multi-domain]  Cd Length: 341  Bit Score: 191.23  E-value: 7.25e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572723465   6 LAKAAEKHGGALNFEAAVGAAIPVIKTLREGLAGTGVTRVYGILNGTCNYILTRMEQEGLSFAECLKDAQRLGYAEANPS 85
Cdd:PRK06270 136 LKELAKKNGVRFRYEATVGGAMPIINLAKETLAGNDIKSIKGILNGTTNYILTRMEEEGLSYEQALAEAQELGYAEADPT 215

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 572723465  86 FDVDGHDTAQKLAILASLAFGTKVAQSAVYVEGISSIAPEDLRAADDLGYRLKLLGVAVRTAKGieqRVHPTMVP 160
Cdd:PRK06270 216 YDVEGIDAALKVVILANSILGADLTIKDVEVEGITKITPEAIELAAKEGYRIKLIGEVSREKDL---SVSPRLVP 287
PRK06813 PRK06813
homoserine dehydrogenase; Validated
 6-149 4.43e-28

homoserine dehydrogenase; Validated


Pssm-ID: 168683 [Multi-domain]  Cd Length: 346  Bit Score: 106.49  E-value: 4.43e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572723465   6 LAKAAEKHGGALNFEAAVGAAIPVIKTLREGLAGTGVTRVYGILNGTCNYILTRMEQEGLSFAECLKDAQRLGYAEANPS 85
Cdd:PRK06813 133 INEAAKIANVRIRYSGATAAALPTLDIGQFSLAGCHIEKIEGILNGTTNYILTKMNEEDITFEEALKEAQSKGIAETNPI 212

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 572723465  86 FDVDGHDTAQKLAILASLAFGTKVAQSAVYVEGISSIAPEDLRAADDLGYRLKLLGVAVRTAKG 149
Cdd:PRK06813 213 LDVSGSDSACKLLLLTNSLMGTENKLTDIHIKGIEHVTKQQIRNAKEQNKIIKLIASAYKDNEG 276
PRK08374 PRK08374
homoserine dehydrogenase; Provisional
 2-160 6.10e-27

homoserine dehydrogenase; Provisional


Pssm-ID: 169409 [Multi-domain]  Cd Length: 336  Bit Score: 102.96  E-value: 6.10e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572723465   2 HGLKLAKAAEKHGGALNFEAAVGAAIPVIKTLREGLAGTGVTRVYGILNGTCNYILTRMEQeGLSFAECLKDAQRLGYAE 81
Cdd:PRK08374 129 HYDELLDLANERNLPYLFEATVMAGTPIIGLLRENLLGDTVKRIEAVVNATTTFILTRMEQ-GKTFEEALKEAQTLGIAE 207

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 572723465  82 ANPSFDVDGHDTAQKLAILASLAFgTKVAQSAVYVEGISSIAPEDLRAADDLGYRLKLlgVAVRTAKGIEqrVHPTMVP 160
Cdd:PRK08374 208 RDPSKDIDGIDAGYKATILHWVAF-PPITFEEVGIRGIKDVTEGEIERAKAKGRNVRL--VATVEEGRIS--VKPKKLP 281
thrA PRK09436
bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional
 5-132 2.18e-17

bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional


Pssm-ID: 181856 [Multi-domain]  Cd Length: 819  Bit Score: 77.89  E-value: 2.18e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572723465   5 KLAKAAEKHGGALNFEAAVGAAIPVIKTLREGL-AGTGVTRVYGILNGTCNYILTRMEqEGLSFAECLKDAQRLGYAEAN 83
Cdd:PRK09436 591 QLREAARKSRRKFLYETNVGAGLPVIETLQNLLnAGDELLKFEGILSGSLSFIFGKLD-EGMSFSEATRLAKEKGYTEPD 669

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 572723465  84 PSFDVDGHDTAQKLAILASLAfGTKVAQSAVYVEgisSIAPEDLRAADD 132
Cdd:PRK09436 670 PRDDLSGMDVARKLLILAREA-GYELELEDIEVE---SVLPEEFDASGS 714
PLN02700 PLN02700
homoserine dehydrogenase family protein
 19-154 4.49e-17

homoserine dehydrogenase family protein


Pssm-ID: 215377 [Multi-domain]  Cd Length: 377  Bit Score: 76.73  E-value: 4.49e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572723465  19 FEAAVGAAIPVIKTLREGLA-GTGVTRVYGILNGTCNYILTRMEqEGLSFAECLKDAQRLGYAEANPSFDVDGHDTAQKL 97
Cdd:PLN02700 163 HESTVGAGLPVIASLNRILSsGDPVHRIVGSLSGTLGYVMSELE-DGKPFSEVVKQAKSLGYTEPDPRDDLGGMDVARKA 241

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 572723465  98 AILASLaFGTKVAQSAVYVEGI--SSIAPEDLRAADDLGYRLKLLGvavrtaKGIEQRV 154
Cdd:PLN02700 242 LILARL-LGKRINMDSIKVESLypEEMGPDLMSTDDFLHSGLVELD------LPIEERV 293
PRK06392 PRK06392
homoserine dehydrogenase; Provisional
 9-122 5.73e-15

homoserine dehydrogenase; Provisional


Pssm-ID: 102354 [Multi-domain]  Cd Length: 326  Bit Score: 70.67  E-value: 5.73e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572723465   9 AAEKHGGALNFEAAVGAAIPVIKTLREGLAGTGVTRVYGILNGTCNYILtRMEQEGLSFAECLKDAQRLGYAEANPSFDV 88
Cdd:PRK06392 130 SASKNRRIIRYEATVAGGVPLFSLRDYSTLPSRIKNFRGIVSSTINYVI-RQEANGRGFLDVVKIAQKMGIAETNYSDDL 208

                         90       100       110
                 ....*....|....*....|....*....|....
gi 572723465  89 DGHDTAQKLAILASLAFGTKVAQSAVYVEGISSI 122
Cdd:PRK06392 209 MGLDAARKSVILANHLFGKDYTLRDVTYDGIENI 242
metL PRK09466
bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional
 9-129 1.06e-07

bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional


Pssm-ID: 236530 [Multi-domain]  Cd Length: 810  Bit Score: 49.92  E-value: 1.06e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572723465   9 AAEKHGGALNFEAAVGAAIPV---IKTLREglAGTGVTRVYGILNGTCNYiLTRMEQEGLSFAECLKDAQRLGYAEANPS 85
Cdd:PRK09466 589 AFAKTGRHWLYNATVGAGLPInhtVRDLRN--SGDSILAISGIFSGTLSW-LFLQFDGSVPFSELVDQAWQQGLTEPDPR 665

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 572723465  86 FDVDGHDTAQKLAILASLAfGTKVAQSAVYVEgisSIAPEDLRA 129
Cdd:PRK09466 666 DDLSGRDVMRKLVILAREA-GYEIEPDDVRVE---SLVPAHLED 705
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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