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Conserved domains on  [gi|526132718|gb|AGR66520|]
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phosphate-solubilizing protein [Burkholderia cepacia]

Protein Classification

ABC transporter permease( domain architecture ID 30)

ABC transporter permease is the transmembrane subunit (TM) found in periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporters which generally bind type 2 PBPs

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TM_PBP2 super family cl00427
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 3-119 1.61e-30

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


The actual alignment was detected with superfamily member PRK15135:

Pssm-ID: 444901 [Multi-domain]  Cd Length: 228  Bit Score: 109.11  E-value: 1.61e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 526132718   3 TDALGWDQIDIDPFLAGVLVLGFIYGAYFTETFRGGScrcraassrpAAVRDDQLAGVHADHVPADDALR---------- 72
Cdd:PRK15135  80 TEALGVGQIDIDPMVAGIITLGFIYGAYFTETFRGAF----------MAVPKGHIEAATAFGFTRGQVFRrimfpammry 149

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 526132718  73 --AGHRNNWQVLVKSTALVSIIGLADVVKASQDAGKGTLRFFFFTLIAG 119
Cdd:PRK15135 150 alPGIGNNWQVILKATALVSLLGLEDVVKATQLAGKSTWEPFYFAIVCG 198
 
Name Accession Description Interval E-value
PRK15135 PRK15135
histidine ABC transporter permease HisQ;
3-119 1.61e-30

histidine ABC transporter permease HisQ;


Pssm-ID: 185089 [Multi-domain]  Cd Length: 228  Bit Score: 109.11  E-value: 1.61e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 526132718   3 TDALGWDQIDIDPFLAGVLVLGFIYGAYFTETFRGGScrcraassrpAAVRDDQLAGVHADHVPADDALR---------- 72
Cdd:PRK15135  80 TEALGVGQIDIDPMVAGIITLGFIYGAYFTETFRGAF----------MAVPKGHIEAATAFGFTRGQVFRrimfpammry 149

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 526132718  73 --AGHRNNWQVLVKSTALVSIIGLADVVKASQDAGKGTLRFFFFTLIAG 119
Cdd:PRK15135 150 alPGIGNNWQVILKATALVSLLGLEDVVKATQLAGKSTWEPFYFAIVCG 198
ArtQ COG4215
ABC-type arginine transport system, permease component [Amino acid transport and metabolism];
3-119 4.62e-28

ABC-type arginine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443361 [Multi-domain]  Cd Length: 238  Bit Score: 102.90  E-value: 4.62e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 526132718   3 TDALGWDQ-IDIDPFLAGVLVLGFIYGAYFTETFRGgscrcraassrpaAVRddqlaGVHADHVPADDALRAGHR----- 76
Cdd:COG4215   89 ADLFGYDGfIEINPFVAGVLALGFVFGAYATEVFRG-------------AFL-----AVPKGQIEAARAYGMSRWqvfrr 150

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 526132718  77 ---------------NNWQVLVKSTALVSIIGLADVVKASQDAGKGTLRFFFFTLIAG 119
Cdd:COG4215  151 illpqmwryalpglgNNWLVLLKDTALVSVIGLVDLVRQAQEAAGSTREPFTFYLAAA 208
HEQRo_perm_3TM TIGR01726
amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This ...
 11-37 1.90e-03

amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This model represents one of several classes of multiple membrane spanning regions found immediately N-terminal to the domain described by pfam00528, binding-protein-dependent transport systems inner membrane component. The region covered by this model generally is predicted to contain three transmembrane helices. Substrate specificities attributed to members of this family include histidine, arginine, glutamine, glutamate, and (in Agrobacterium) the opines octopine and nopaline. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130787 [Multi-domain]  Cd Length: 99  Bit Score: 35.20  E-value: 1.90e-03
                          10        20
                  ....*....|....*....|....*..
gi 526132718   11 IDIDPFLAGVLVLGFIYGAYFTETFRG 37
Cdd:TIGR01726  73 IRLSPLTAAVIALTLFYGAYLAEIFRG 99
 
Name Accession Description Interval E-value
PRK15135 PRK15135
histidine ABC transporter permease HisQ;
3-119 1.61e-30

histidine ABC transporter permease HisQ;


Pssm-ID: 185089 [Multi-domain]  Cd Length: 228  Bit Score: 109.11  E-value: 1.61e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 526132718   3 TDALGWDQIDIDPFLAGVLVLGFIYGAYFTETFRGGScrcraassrpAAVRDDQLAGVHADHVPADDALR---------- 72
Cdd:PRK15135  80 TEALGVGQIDIDPMVAGIITLGFIYGAYFTETFRGAF----------MAVPKGHIEAATAFGFTRGQVFRrimfpammry 149

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 526132718  73 --AGHRNNWQVLVKSTALVSIIGLADVVKASQDAGKGTLRFFFFTLIAG 119
Cdd:PRK15135 150 alPGIGNNWQVILKATALVSLLGLEDVVKATQLAGKSTWEPFYFAIVCG 198
ArtQ COG4215
ABC-type arginine transport system, permease component [Amino acid transport and metabolism];
3-119 4.62e-28

ABC-type arginine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443361 [Multi-domain]  Cd Length: 238  Bit Score: 102.90  E-value: 4.62e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 526132718   3 TDALGWDQ-IDIDPFLAGVLVLGFIYGAYFTETFRGgscrcraassrpaAVRddqlaGVHADHVPADDALRAGHR----- 76
Cdd:COG4215   89 ADLFGYDGfIEINPFVAGVLALGFVFGAYATEVFRG-------------AFL-----AVPKGQIEAARAYGMSRWqvfrr 150

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 526132718  77 ---------------NNWQVLVKSTALVSIIGLADVVKASQDAGKGTLRFFFFTLIAG 119
Cdd:COG4215  151 illpqmwryalpglgNNWLVLLKDTALVSVIGLVDLVRQAQEAAGSTREPFTFYLAAA 208
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 11-119 3.39e-09

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 52.77  E-value: 3.39e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 526132718  11 IDIDPFLAGVLVLGFIYGAYFTETFRGGscrcraassrpaavrddqLAGVHADHVPADDALRAGHR-------------- 76
Cdd:COG0765   83 IDLSPFVAAVIALTLNSAAYLAEIVRAG------------------IQSVPKGQWEAARALGLSRWqtmrriilpqalri 144

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 526132718  77 ------NNWQVLVKSTALVSIIGLADVVKASQDAGKGTLRFFFFTLIAG 119
Cdd:COG0765  145 ilpplgNEFISLLKDTSLVSVIGVPELTRAAQQIASRTFRPFEVYLVAA 193
PRK11123 PRK11123
arginine ABC transporter permease ArtQ;
9-102 6.53e-08

arginine ABC transporter permease ArtQ;


Pssm-ID: 182979 [Multi-domain]  Cd Length: 238  Bit Score: 49.29  E-value: 6.53e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 526132718   9 DQIDIDPFLAGVLVLGFIYGAYFTETFRG-------GSCRCRAA--SSR---------PAAVRddqlagvHAdhVPadda 70
Cdd:PRK11123  97 ENFEVSPFLCGVIALSLLYAAYASQTLRGalkavpvGQWESGQAlgLSKsaiffrlvmPQMWR-------HA--LP---- 163

                         90       100       110
                 ....*....|....*....|....*....|..
gi 526132718  71 lraGHRNNWQVLVKSTALVSIIGLADVVKASQ 102
Cdd:PRK11123 164 ---GLGNQWLVLLKDTALVSLISVNDLMLQTK 192
HEQRo_perm_3TM TIGR01726
amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This ...
 11-37 1.90e-03

amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This model represents one of several classes of multiple membrane spanning regions found immediately N-terminal to the domain described by pfam00528, binding-protein-dependent transport systems inner membrane component. The region covered by this model generally is predicted to contain three transmembrane helices. Substrate specificities attributed to members of this family include histidine, arginine, glutamine, glutamate, and (in Agrobacterium) the opines octopine and nopaline. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130787 [Multi-domain]  Cd Length: 99  Bit Score: 35.20  E-value: 1.90e-03
                          10        20
                  ....*....|....*....|....*..
gi 526132718   11 IDIDPFLAGVLVLGFIYGAYFTETFRG 37
Cdd:TIGR01726  73 IRLSPLTAAVIALTLFYGAYLAEIFRG 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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