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Conserved domains on  [gi|472831426|gb|AGI47163|]
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tRNA(1-methyladenosine) methyltransferase-related methyltransferase [Thermoplasmatales archaeon BRNA1]

Protein Classification

tRNA (adenine-N1)-methyltransferase( domain architecture ID 11457537)

tRNA (adenine-N1)-methyltransferase, such as tRNA (adenine(58)-N(1))-methyltransferase, which is a class I SAM-dependent methyltransferase that catalyzes the methylation of N(1)-adenine at position 58 (m1A58) in tRNA using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 5-252 1.30e-106

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


:

Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 308.24  E-value: 1.30e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472831426   5 EGEYLYIEDESGKKFWFRLEFGMVKMGGLGVIDGKKFQGLDDGDTVDI-VGKQFAVFRPTVTDLMESLDRGAQIITPKDA 83
Cdd:COG2519    1 EGDRVLLTDPKGRKYLVRLEEGKKFHTHKGIIDHDDLIGKPEGSVVTTsKGKEFLVLRPTLYDYVLSMKRGTQIIYPKDA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472831426  84 SAIILECDIHEGTKVIEVGAGSGGLTTALLAAVGKTGHVHTLEIKEQNAERVLKNLKRTGLDASWSYQIGDAREmEIDYG 163
Cdd:COG2519   81 GYIIARLDIFPGARVLEAGTGSGALTLALARAVGPEGKVYSYERREDFAEIARKNLERFGLPDNVELKLGDIRE-GIDEG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472831426 164 MADVVTTDMPDPENAIDNLSKHLRNGGRICTYVPNANQLDLAVRALRDRGFVDVRSFEIMRRGMEVHPGGVRPSFEMLGH 243
Cdd:COG2519  160 DVDAVFLDMPDPWEALEAVAKALKPGGVLVAYVPTVNQVSKLVEALRESGFTDIEAVETLLREWKVEGLAVRPEHRMVGH 239


                 ....*....
gi 472831426 244 TGYLTFARK 252
Cdd:COG2519  240 TGFLVFARK 248
 
Name Accession Description Interval E-value
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 5-252 1.30e-106

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 308.24  E-value: 1.30e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472831426   5 EGEYLYIEDESGKKFWFRLEFGMVKMGGLGVIDGKKFQGLDDGDTVDI-VGKQFAVFRPTVTDLMESLDRGAQIITPKDA 83
Cdd:COG2519    1 EGDRVLLTDPKGRKYLVRLEEGKKFHTHKGIIDHDDLIGKPEGSVVTTsKGKEFLVLRPTLYDYVLSMKRGTQIIYPKDA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472831426  84 SAIILECDIHEGTKVIEVGAGSGGLTTALLAAVGKTGHVHTLEIKEQNAERVLKNLKRTGLDASWSYQIGDAREmEIDYG 163
Cdd:COG2519   81 GYIIARLDIFPGARVLEAGTGSGALTLALARAVGPEGKVYSYERREDFAEIARKNLERFGLPDNVELKLGDIRE-GIDEG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472831426 164 MADVVTTDMPDPENAIDNLSKHLRNGGRICTYVPNANQLDLAVRALRDRGFVDVRSFEIMRRGMEVHPGGVRPSFEMLGH 243
Cdd:COG2519  160 DVDAVFLDMPDPWEALEAVAKALKPGGVLVAYVPTVNQVSKLVEALRESGFTDIEAVETLLREWKVEGLAVRPEHRMVGH 239


                 ....*....
gi 472831426 244 TGYLTFARK 252
Cdd:COG2519  240 TGFLVFARK 248
GCD14 pfam08704
tRNA methyltransferase complex GCD14 subunit; GCD14 is a subunit of the tRNA methyltransferase ...
 71-252 4.33e-33

tRNA methyltransferase complex GCD14 subunit; GCD14 is a subunit of the tRNA methyltransferase complex and is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA.


Pssm-ID: 312288  Cd Length: 242  Bit Score: 120.29  E-value: 4.33e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472831426   71 LDRGAQIITPKDASAIILECDIHEGTKVIEVGAGSGGLTTALLAAVGKTGHVHTLEIKEQNAERVLKNLKRTGLDASWSY 150
Cdd:pfam08704  17 LPHRTQILYTPDISLITMMLELRPGSVVCESGTGSGSLSHAIIRTVAPTGHLFTFEFHEQRADKAREEFREHGIDQLVTV 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472831426  151 QIGDARE----MEIDyGMADVVTTDMPDPENAIDNLSKHLR-NGGRICTYVPNANQLDLAVRALRDRGFVDVRSFEIM-- 223
Cdd:pfam08704  97 THRDVCKegflTEVS-GKADAVFLDLPSPWEAVPHAWKALKvEGGRFCSFSPCIEQVQRTCQALAELGFTEISTLEVLlr 175

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 472831426  224 --------------------------------------RRGMEVHPGGVRPSFEMLGHTGYLTFARK 252
Cdd:pfam08704 176 vydvrtvslpvidlgidrekenertrteglsnddksedNSGNSMLGTALKPMSEAVGHTGYLTFATK 242
PRK13942 PRK13942
protein-L-isoaspartate O-methyltransferase; Provisional
 69-145 4.48e-07

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 184409  Cd Length: 212  Bit Score: 49.24  E-value: 4.48e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472831426  69 ESLDRGAQIITP------KDASAIIL------ECDIHEGTKVIEVGAGSGGLTTALLAAVGKTGHVHTLEIKEQNAERVL 136
Cdd:PRK13942  39 EYLEEYAYVDTPleigygQTISAIHMvaimceLLDLKEGMKVLEIGTGSGYHAAVVAEIVGKSGKVVTIERIPELAEKAK 118


                 ....*....
gi 472831426 137 KNLKRTGLD 145
Cdd:PRK13942 119 KTLKKLGYD 127
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 97-192 9.62e-05

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 40.49  E-value: 9.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472831426  97 KVIEVGAGSGGLTTALLAAVGKtgHVHTLEIKEQNAERvLKNLKRTGLDASWSYQIGDARE-MEIDYGMADVVTTDMP-- 173
Cdd:cd02440    1 RVLDLGCGTGALALALASGPGA--RVTGVDISPVALEL-ARKAAAALLADNVEVLKGDAEElPPEADESFDVIISDPPlh 77

                         90       100
                 ....*....|....*....|...
gi 472831426 174 ----DPENAIDNLSKHLRNGGRI 192
Cdd:cd02440   78 hlveDLARFLEEARRLLKPGGVL 100
rADc smart00650
Ribosomal RNA adenine dimethylases;
91-127 2.50e-03

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 37.49  E-value: 2.50e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 472831426    91 DIHEGTKVIEVGAGSGGLTTALLAAVGKtghVHTLEI 127
Cdd:smart00650  10 NLRPGDTVLEIGPGKGALTEELLERAKR---VTAIEI 43
CbiT TIGR02469
precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; This model recognizes ...
 92-192 5.11e-03

precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; This model recognizes the CbiT methylase which is responsible, in part (along with CbiE), for methylating precorrin-6y (or cobalt-precorrin-6y) at both the 5 and 15 positions as well as the concomitant decarbozylation at C-12. In many organisms, this protein is fused to the CbiE subunit. The fused protein, when found in organisms catalyzing the oxidative version of the cobalamin biosynthesis pathway, is called CobL. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 274148 [Multi-domain]  Cd Length: 124  Bit Score: 36.15  E-value: 5.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472831426   92 IHEGTKVIEVGAGSGGLTTALLAAVGKtGHVHTLEIKEQNAERVLKNLKRTGLDaswSYQI--GDAREMEIDygmadvvt 169
Cdd:TIGR02469  17 LRPGDVLWDIGAGTGSVTIEAARLVPN-GRVYAIERNPEALDLIERNLRRFGVS---NIVIveGDAPEAPEA-------- 84

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 472831426  170 tDMPDPENA------------IDNLSKHLRNGGRI 192
Cdd:TIGR02469  85 -LLPDPDAVfvggsggllqeiLEAVERRLRPGGRI 118
 
Name Accession Description Interval E-value
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 5-252 1.30e-106

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 308.24  E-value: 1.30e-106
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472831426   5 EGEYLYIEDESGKKFWFRLEFGMVKMGGLGVIDGKKFQGLDDGDTVDI-VGKQFAVFRPTVTDLMESLDRGAQIITPKDA 83
Cdd:COG2519    1 EGDRVLLTDPKGRKYLVRLEEGKKFHTHKGIIDHDDLIGKPEGSVVTTsKGKEFLVLRPTLYDYVLSMKRGTQIIYPKDA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472831426  84 SAIILECDIHEGTKVIEVGAGSGGLTTALLAAVGKTGHVHTLEIKEQNAERVLKNLKRTGLDASWSYQIGDAREmEIDYG 163
Cdd:COG2519   81 GYIIARLDIFPGARVLEAGTGSGALTLALARAVGPEGKVYSYERREDFAEIARKNLERFGLPDNVELKLGDIRE-GIDEG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472831426 164 MADVVTTDMPDPENAIDNLSKHLRNGGRICTYVPNANQLDLAVRALRDRGFVDVRSFEIMRRGMEVHPGGVRPSFEMLGH 243
Cdd:COG2519  160 DVDAVFLDMPDPWEALEAVAKALKPGGVLVAYVPTVNQVSKLVEALRESGFTDIEAVETLLREWKVEGLAVRPEHRMVGH 239


                 ....*....
gi 472831426 244 TGYLTFARK 252
Cdd:COG2519  240 TGFLVFARK 248
GCD14 pfam08704
tRNA methyltransferase complex GCD14 subunit; GCD14 is a subunit of the tRNA methyltransferase ...
 71-252 4.33e-33

tRNA methyltransferase complex GCD14 subunit; GCD14 is a subunit of the tRNA methyltransferase complex and is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA.


Pssm-ID: 312288  Cd Length: 242  Bit Score: 120.29  E-value: 4.33e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472831426   71 LDRGAQIITPKDASAIILECDIHEGTKVIEVGAGSGGLTTALLAAVGKTGHVHTLEIKEQNAERVLKNLKRTGLDASWSY 150
Cdd:pfam08704  17 LPHRTQILYTPDISLITMMLELRPGSVVCESGTGSGSLSHAIIRTVAPTGHLFTFEFHEQRADKAREEFREHGIDQLVTV 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472831426  151 QIGDARE----MEIDyGMADVVTTDMPDPENAIDNLSKHLR-NGGRICTYVPNANQLDLAVRALRDRGFVDVRSFEIM-- 223
Cdd:pfam08704  97 THRDVCKegflTEVS-GKADAVFLDLPSPWEAVPHAWKALKvEGGRFCSFSPCIEQVQRTCQALAELGFTEISTLEVLlr 175

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 472831426  224 --------------------------------------RRGMEVHPGGVRPSFEMLGHTGYLTFARK 252
Cdd:pfam08704 176 vydvrtvslpvidlgidrekenertrteglsnddksedNSGNSMLGTALKPMSEAVGHTGYLTFATK 242
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 85-214 4.22e-11

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 59.24  E-value: 4.22e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472831426  85 AIILECDIHEGTKVIEVGAGSGGLTTALLAAvgkTGHVHTLEIKEQNAERVLKNLKRTGLDASWsyQIGDAREMEIDYGM 164
Cdd:COG2226   13 ALLAALGLRPGARVLDLGCGTGRLALALAER---GARVTGVDISPEMLELARERAAEAGLNVEF--VVGDAEDLPFPDGS 87

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 472831426 165 ADVVTT-----DMPDPENAIDNLSKHLRNGGRICTYVPNANQLDLAVRALRDRGF 214
Cdd:COG2226   88 FDLVISsfvlhHLPDPERALAEIARVLKPGGRLVVVDFSPPDLAELEELLAEAGF 142
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 92-198 4.23e-10

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 56.18  E-value: 4.23e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472831426  92 IHEGTKVIEVGAGSGGLTtALLAAVGKtgHVHTLEIKEQNAERVLKNLKRTGLDaswsYQIGDAREMEIDYGMADVVTT- 170
Cdd:COG2227   22 LPAGGRVLDVGCGTGRLA-LALARRGA--DVTGVDISPEALEIARERAAELNVD----FVQGDLEDLPLEDGSFDLVICs 94

                         90       100       110
                 ....*....|....*....|....*....|..
gi 472831426 171 ----DMPDPENAIDNLSKHLRNGGRICTYVPN 198
Cdd:COG2227   95 evleHLPDPAALLRELARLLKPGGLLLLSTPN 126
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 98-190 3.64e-09

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 52.57  E-value: 3.64e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472831426   98 VIEVGAGSGGLTTALLAAVGktGHVHTLEIKEQNAERVLKNLKRTGLDASWsyQIGDAREMEIDYGMADVVT-------T 170
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGG--ARVTGVDLSPEMLERARERAAEAGLNVEF--VQGDAEDLPFPDGSFDLVVssgvlhhL 76

                          90       100
                  ....*....|....*....|
gi 472831426  171 DMPDPENAIDNLSKHLRNGG 190
Cdd:pfam13649  77 PDPDLEAALREIARVLKPGG 96
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 96-211 4.26e-08

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 51.34  E-value: 4.26e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472831426  96 TKVIEVGAGSGGLTTALLAAVGKTGHVHTLEIKEQNAERVLKNLKRTGLDASWSYQIGDAREM--EIDYGMADVV----- 168
Cdd:COG4122   18 KRILEIGTGTGYSTLWLARALPDDGRLTTIEIDPERAAIARENFARAGLADRIRLILGDALEVlpRLADGPFDLVfidad 97

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 472831426 169 TTDMPDpenAIDNLSKHLRNGGRICT-------YVPNANQLDLAVRALRD 211
Cdd:COG4122   98 KSNYPD---YLELALPLLRPGGLIVAdnvlwhgRVADPARRDPSTRAIRE 144
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 85-145 1.00e-07

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 50.86  E-value: 1.00e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 472831426  85 AIILE-CDIHEGTKVIEVGAGSgGLTTALLAAVGktGHVHTLEIKEQNAERVLKNLKRTGLD 145
Cdd:COG2518   56 ARMLEaLDLKPGDRVLEIGTGS-GYQAAVLARLA--GRVYSVERDPELAERARERLAALGYD 114
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 92-193 2.23e-07

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 48.95  E-value: 2.23e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472831426   92 IHEGTKVIEVGAGSGGLTTALLAAVGKTGHVHTLEIKEQNAERVLKNLKRTGLDaSWSYQIGDAREMEIDYGMA--DVVT 169
Cdd:pfam13847   1 IDKGMRVLDLGCGTGHLSFELAEELGPNAEVVGIDISEEAIEKARENAQKLGFD-NVEFEQGDIEELPELLEDDkfDVVI 79

                          90       100
                  ....*....|....*....|....*....
gi 472831426  170 TD-----MPDPENAIDNLSKHLRNGGRIC 193
Cdd:pfam13847  80 SNcvlnhIPDPDKVLQEILRVLKPGGRLI 108
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 78-230 2.97e-07

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 49.18  E-value: 2.97e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472831426  78 ITPKDASAIILECDIHEGTKVIEVGAGSGG-LTTALLA---AVGktghvhtLEIKEQNAERVLKNLKRTGLDaSWSYQIG 153
Cdd:COG1041   10 LDPRLARALVNLAGAKEGDTVLDPFCGTGTiLIEAGLLgrrVIG-------SDIDPKMVEGARENLEHYGYE-DADVIRG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472831426 154 DAREMEIDYGMADVVTTDMP----------DPEN----AIDNLSKHLRNGGRICTYVPnanqlDLAVRALRDRGFVDVRS 219
Cdd:COG1041   82 DARDLPLADESVDAIVTDPPygrsskisgeELLElyekALEEAARVLKPGGRVVIVTP-----RDIDELLEEAGFKVLER 156

                        170
                 ....*....|.
gi 472831426 220 FEimrrgMEVH 230
Cdd:COG1041  157 HE-----QRVH 162
PRK13942 PRK13942
protein-L-isoaspartate O-methyltransferase; Provisional
 69-145 4.48e-07

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 184409  Cd Length: 212  Bit Score: 49.24  E-value: 4.48e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472831426  69 ESLDRGAQIITP------KDASAIIL------ECDIHEGTKVIEVGAGSGGLTTALLAAVGKTGHVHTLEIKEQNAERVL 136
Cdd:PRK13942  39 EYLEEYAYVDTPleigygQTISAIHMvaimceLLDLKEGMKVLEIGTGSGYHAAVVAEIVGKSGKVVTIERIPELAEKAK 118


                 ....*....
gi 472831426 137 KNLKRTGLD 145
Cdd:PRK13942 119 KTLKKLGYD 127
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 99-192 2.25e-06

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 45.05  E-value: 2.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472831426   99 IEVGAGSGGLTTALLAAVGkTGHVHTLEIKEQNAERVLKNLKRTGLDASWSYQIGDAREMEIDYGMADVVTT-----DMP 173
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALP-GLEYTGLDISPAALEAARERLAALGLLNAVRVELFQLDLGELDPGSFDVVVAsnvlhHLA 79

                          90
                  ....*....|....*....
gi 472831426  174 DPENAIDNLSKHLRNGGRI 192
Cdd:pfam08242  80 DPRAVLRNIRRLLKPGGVL 98
CobL COG2242
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part ...
 78-222 3.91e-06

Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441843 [Multi-domain]  Cd Length: 403  Bit Score: 47.47  E-value: 3.91e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472831426  78 ITPKDASAIIL-ECDIHEGTKVIEVGAGSGGLTT--ALLAavgKTGHVHTLEIKEQNAERVLKNLKRTGLDaswsyqigd 154
Cdd:COG2242  230 ITKREVRALTLaKLALRPGDVLWDIGAGSGSVSIeaARLA---PGGRVYAIERDPERAALIRANARRFGVP--------- 297

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472831426 155 arEMEIDYGMADVVTTDMPDP------------ENAIDNLSKHLRNGGRIctyVPNANQLD---LAVRALRDRGF-VDVR 218
Cdd:COG2242  298 --NVEVVEGEAPEALADLPDPdavfiggsggnlPEILEACWARLRPGGRL---VANAVTLEtlaLALEALAELGYgGELV 372


                 ....
gi 472831426 219 SFEI 222
Cdd:COG2242  373 QVQV 376
PRK08317 PRK08317
hypothetical protein; Provisional
 91-192 2.01e-05

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 44.54  E-value: 2.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472831426  91 DIHEGTKVIEVGAGSGGLTTALLAAVGKTGHVHTLEIKEQNAERVlknLKRTGLDASW-SYQIGDAREMEIDYGMADVVT 169
Cdd:PRK08317  16 AVQPGDRVLDVGCGPGNDARELARRVGPEGRVVGIDRSEAMLALA---KERAAGLGPNvEFVRGDADGLPFPDGSFDAVR 92

                         90       100
                 ....*....|....*....|....*...
gi 472831426 170 TD-----MPDPENAIDNLSKHLRNGGRI 192
Cdd:PRK08317  93 SDrvlqhLEDPARALAEIARVLRPGGRV 120
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
92-244 2.51e-05

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 44.26  E-value: 2.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472831426  92 IHEGTKVIEVGAGSGGLttALLAAVGKTGHVHTLEIKEQNAERVLKNLKRTGLDASWSYQIGDAREMEIDyGMADVVTTD 171
Cdd:COG4076   33 VKPGDVVLDIGTGSGLL--SMLAARAGAKKVYAVEVNPDIAAVARRIIAANGLSDRITVINADATDLDLP-EKADVIISE 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472831426 172 MPD----PENAIDNLS----KHLRNGGRIctyVPNA-------NQLDLAVRALRDRGF--VDVRSFEIMRRGM---EVHP 231
Cdd:COG4076  110 MLDtallDEGQVPILNharkRLLKPGGRI---IPERitnaaqpVESPVDAEGFEDWQFdgFDFRLFGFLLYAEpllHLTR 186

                        170
                 ....*....|...
gi 472831426 232 GGVRPSFEMLGHT 244
Cdd:COG4076  187 LVRTPLLLLLLPT 199
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 91-197 3.33e-05

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 42.99  E-value: 3.33e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472831426  91 DIHEGTKVIEVGAGSGGLttaLLAAVGKTG-HVHTLEIKEQNAERVLKNLKRTGLDASWSYQIGDAREMEIDyGMAD-VV 168
Cdd:COG2230   48 GLKPGMRVLDIGCGWGGL---ALYLARRYGvRVTGVTLSPEQLEYARERAAEAGLADRVEVRLADYRDLPAD-GQFDaIV 123

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 472831426 169 TTDM------PDPENAIDNLSKHLRNGGRICTYVP 197
Cdd:COG2230  124 SIGMfehvgpENYPAYFAKVARLLKPGGRLLLHTP 158
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
91-201 4.58e-05

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 43.13  E-value: 4.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472831426   91 DIHEGTKVIEVGAGSGGLTTALLAAVGKTGHVHTLEIKEQNAERVLKNLKRTGLDaSWSYQIGDAREMEIDYGMADV--V 168
Cdd:pfam01135  70 ELKPGMRVLEIGSGSGYLTACFARMVGEVGRVVSIEHIPELVEIARRNLEKLGLE-NVIVVVGDGRQGWPEFAPYDAihV 148

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 472831426  169 TTDMPD-PENAIDnlskHLRNGGRICTYV-PNANQ 201
Cdd:pfam01135 149 GAAAPEiPEALID----QLKEGGRLVIPVgPNGNQ 179
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 97-192 9.62e-05

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 40.49  E-value: 9.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472831426  97 KVIEVGAGSGGLTTALLAAVGKtgHVHTLEIKEQNAERvLKNLKRTGLDASWSYQIGDARE-MEIDYGMADVVTTDMP-- 173
Cdd:cd02440    1 RVLDLGCGTGALALALASGPGA--RVTGVDISPVALEL-ARKAAAALLADNVEVLKGDAEElPPEADESFDVIISDPPlh 77

                         90       100
                 ....*....|....*....|...
gi 472831426 174 ----DPENAIDNLSKHLRNGGRI 192
Cdd:cd02440   78 hlveDLARFLEEARRLLKPGGVL 100
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 99-193 1.59e-04

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 39.57  E-value: 1.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472831426   99 IEVGAGSGgLTTALLAAVGKtgHVHTLEIKEQNAERVLKNLKRTGLDaswsYQIGDAREMEIDYGMADVVTT-----DMP 173
Cdd:pfam08241   1 LDVGCGTG-LLTELLARLGA--RVTGVDISPEMLELAREKAPREGLT----FVVGDAEDLPFPDNSFDLVLSsevlhHVE 73

                          90       100
                  ....*....|....*....|
gi 472831426  174 DPENAIDNLSKHLRNGGRIC 193
Cdd:pfam08241  74 DPERALREIARVLKPGGILI 93
COG3963 COG3963
Phosphatidylethanolamine N-methyltransferase [Lipid transport and metabolism];
98-219 2.51e-04

Phosphatidylethanolamine N-methyltransferase [Lipid transport and metabolism];


Pssm-ID: 443163  Cd Length: 193  Bit Score: 40.96  E-value: 2.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472831426  98 VIEVGAGSGGLTTALLAAVGKTGHVHTLEIKEQNAERvlknLKRT--GLDASWsyqiGDAREM-----EIDYGMADVV-- 168
Cdd:COG3963   49 VVELGPGTGVFTRAILARGVPDARLLAVEINPEFAEH----LRRRfpRVTVVN----GDAEDLaellaEHGIGKVDAVvs 120

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 472831426 169 ----TTdMPDPE-NAI-DNLSKHLRNGGRI--CTYVPNANQldlaVRALRDRGFVDVRS 219
Cdd:COG3963  121 glplLS-FPPELrRAIlDAAFRVLAPGGVFvqFTYSPRSPV----PRKLLRRGFEAVRS 174
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
94-192 2.62e-04

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 39.04  E-value: 2.62e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472831426  94 EGTKVIEVGAGSGGLtTALLAAVGKTGHVHTLEIkeqnAERVLKNLKRTGLDASWsyQIGDAREMEIDyGMADVVTTD-- 171
Cdd:COG4106    1 PPRRVLDLGCGTGRL-TALLAERFPGARVTGVDL----SPEMLARARARLPNVRF--VVADLRDLDPP-EPFDLVVSNaa 72

                         90       100
                 ....*....|....*....|....
gi 472831426 172 ---MPDPENAIDNLSKHLRNGGRI 192
Cdd:COG4106   73 lhwLPDHAALLARLAAALAPGGVL 96
RsmA COG0030
16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase ...
 86-127 2.63e-04

16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) [Translation, ribosomal structure and biogenesis]; 16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439801 [Multi-domain]  Cd Length: 270  Bit Score: 41.26  E-value: 2.63e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 472831426  86 IILECDIHEGTKVIEVGAGSGGLTTALLAAVgktGHVHTLEI 127
Cdd:COG0030   29 IVDAAGITPGDTVLEIGPGLGALTRALLERA---ARVTAVEI 67
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
65-214 2.86e-04

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 40.75  E-value: 2.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472831426  65 TDLMESLD-RGAQIItpkdASAIILECDIHEGTKVIEVGAGSgGLTTALLAAVGktGHVHTLEIkeqnAERVLKNLKRTG 143
Cdd:COG4976   20 AALVEDLGyEAPALL----AEELLARLPPGPFGRVLDLGCGT-GLLGEALRPRG--YRLTGVDL----SEEMLAKAREKG 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472831426 144 LDASWsyQIGDAREMEIDYGMADVVT-----TDMPDPENAIDNLSKHLRNGGRICTYVPNANQ-------LDLAVRALRD 211
Cdd:COG4976   89 VYDRL--LVADLADLAEPDGRFDLIVaadvlTYLGDLAAVFAGVARALKPGGLFIFSVEDADGsgryahsLDYVRDLLAA 166


                 ...
gi 472831426 212 RGF 214
Cdd:COG4976  167 AGF 169
pcm PRK00312
protein-L-isoaspartate(D-aspartate) O-methyltransferase;
85-145 1.70e-03

protein-L-isoaspartate(D-aspartate) O-methyltransferase;


Pssm-ID: 178974 [Multi-domain]  Cd Length: 212  Bit Score: 38.65  E-value: 1.70e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 472831426  85 AIILEC-DIHEGTKVIEVGAGSgGLTTALLAAVGKtgHVHTLE-IKEQnAERVLKNLKRTGLD 145
Cdd:PRK00312  68 ARMTELlELKPGDRVLEIGTGS-GYQAAVLAHLVR--RVFSVErIKTL-QWEAKRRLKQLGLH 126
rADc smart00650
Ribosomal RNA adenine dimethylases;
91-127 2.50e-03

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 37.49  E-value: 2.50e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 472831426    91 DIHEGTKVIEVGAGSGGLTTALLAAVGKtghVHTLEI 127
Cdd:smart00650  10 NLRPGDTVLEIGPGKGALTEELLERAKR---VTAIEI 43
CbiT TIGR02469
precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; This model recognizes ...
 92-192 5.11e-03

precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; This model recognizes the CbiT methylase which is responsible, in part (along with CbiE), for methylating precorrin-6y (or cobalt-precorrin-6y) at both the 5 and 15 positions as well as the concomitant decarbozylation at C-12. In many organisms, this protein is fused to the CbiE subunit. The fused protein, when found in organisms catalyzing the oxidative version of the cobalamin biosynthesis pathway, is called CobL. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 274148 [Multi-domain]  Cd Length: 124  Bit Score: 36.15  E-value: 5.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 472831426   92 IHEGTKVIEVGAGSGGLTTALLAAVGKtGHVHTLEIKEQNAERVLKNLKRTGLDaswSYQI--GDAREMEIDygmadvvt 169
Cdd:TIGR02469  17 LRPGDVLWDIGAGTGSVTIEAARLVPN-GRVYAIERNPEALDLIERNLRRFGVS---NIVIveGDAPEAPEA-------- 84

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 472831426  170 tDMPDPENA------------IDNLSKHLRNGGRI 192
Cdd:TIGR02469  85 -LLPDPDAVfvggsggllqeiLEAVERRLRPGGRI 118
PRK10901 PRK10901
16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;
117-156 9.32e-03

16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;


Pssm-ID: 236790 [Multi-domain]  Cd Length: 427  Bit Score: 37.09  E-value: 9.32e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 472831426 117 GKTGH---------VHTLEIKEQNAERVLKNLKRTGLDAswSYQIGDAR 156
Cdd:PRK10901 257 GKTAHilelapqaqVVALDIDAQRLERVRENLQRLGLKA--TVIVGDAR 303
PRK13944 PRK13944
protein-L-isoaspartate O-methyltransferase; Provisional
 71-143 9.44e-03

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 140001  Cd Length: 205  Bit Score: 36.33  E-value: 9.44e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 472831426  71 LDRGAQIITPKdasAIILECDIHE---GTKVIEVGAGSGGLTTALLAAVGKTGHVHTLEIKEQNAERVLKNLKRTG 143
Cdd:PRK13944  49 LFAGATISAPH---MVAMMCELIEprpGMKILEVGTGSGYQAAVCAEAIERRGKVYTVEIVKELAIYAAQNIERLG 121
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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