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Conserved domains on  [gi|449099969|gb|AGE88003|]
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protoporphyrinogen oxidase [Cronobacter sakazakii SP291]

Protein Classification

protoporphyrinogen oxidase( domain architecture ID 10013732)

protoporphyrinogen oxidase catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX using menaquinone as an electron acceptor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
hemG PRK11104
menaquinone-dependent protoporphyrinogen IX dehydrogenase;
1-177 4.60e-129

menaquinone-dependent protoporphyrinogen IX dehydrogenase;


:

Pssm-ID: 182966  Cd Length: 177  Bit Score: 358.89  E-value: 4.60e-129
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449099969   1 MKTLILFSTRDGQTREIAFYIASQLQEmGEAVDVVNLHRAEAPDWTQYKKVVIGASIRYGHFHPTLDAFVKQHQQALNAL 80
Cdd:PRK11104   1 MKTLILYSSRDGQTRKIASYIASELKE-GIQCDVVNLHRIEEPDLSDYDRVVIGASIRYGHFHSALYKFVKKHATQLNQM 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449099969  81 PGAFFSVNLVARKPEKRTPQTNSYTRKFLLNSPWQPDRCAVFAGALRYPRYRWFDRFMIRLIMKMTGGETDTSKEVVYTD 160
Cdd:PRK11104  80 PSAFFSVNLTARKPEKRTPQTNSYARKFLMNSPWQPDLCAVFAGALRYPRYRWFDRFMIKLIMKMTGGETDTSKEVEYTD 159

                        170
                 ....*....|....*..
gi 449099969 161 WPQVALFAQEIARLSRD 177
Cdd:PRK11104 160 WEQVANFAREFAQLTDK 176
 
Name Accession Description Interval E-value
hemG PRK11104
menaquinone-dependent protoporphyrinogen IX dehydrogenase;
1-177 4.60e-129

menaquinone-dependent protoporphyrinogen IX dehydrogenase;


Pssm-ID: 182966  Cd Length: 177  Bit Score: 358.89  E-value: 4.60e-129
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449099969   1 MKTLILFSTRDGQTREIAFYIASQLQEmGEAVDVVNLHRAEAPDWTQYKKVVIGASIRYGHFHPTLDAFVKQHQQALNAL 80
Cdd:PRK11104   1 MKTLILYSSRDGQTRKIASYIASELKE-GIQCDVVNLHRIEEPDLSDYDRVVIGASIRYGHFHSALYKFVKKHATQLNQM 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449099969  81 PGAFFSVNLVARKPEKRTPQTNSYTRKFLLNSPWQPDRCAVFAGALRYPRYRWFDRFMIRLIMKMTGGETDTSKEVVYTD 160
Cdd:PRK11104  80 PSAFFSVNLTARKPEKRTPQTNSYARKFLMNSPWQPDLCAVFAGALRYPRYRWFDRFMIKLIMKMTGGETDTSKEVEYTD 159

                        170
                 ....*....|....*..
gi 449099969 161 WPQVALFAQEIARLSRD 177
Cdd:PRK11104 160 WEQVANFAREFAQLTDK 176
HemG COG4635
Protoporphyrinogen IX oxidase, menaquinone-dependent (flavodoxin domain) [Coenzyme transport ...
 1-174 2.09e-105

Protoporphyrinogen IX oxidase, menaquinone-dependent (flavodoxin domain) [Coenzyme transport and metabolism];


Pssm-ID: 443673  Cd Length: 179  Bit Score: 299.50  E-value: 2.09e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449099969   1 MKTLILFSTRDGQTREIAFYIASQLQEMGEAVDVVNLHRAEAPDWTQYKKVVIGASIRYGHFHPTLDAFVKQHQQALNAL 80
Cdd:COG4635    1 MKVLILYASRDGQTRKIAERIAEVLREAGHDVDLVDLEDAPDLDLAGYDAVVIGASIRYGKWLPEAVRFVRRHRDALAAR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449099969  81 PGAFFSVNLVARKPEKRTPQTNSYTRKFLLNSPWQPDRCAVFAGALRYPRYRWFDRFMIRLIMKMTGGETDTSKEVVYTD 160
Cdd:COG4635   81 PVAFFSVSLTARKPEKRTPETNAYLRKFLAKTGWQPDLVAVFAGALDYPRYGFFDRLMIRLIMKMTGGETDTSRDGEYTD 160

                        170
                 ....*....|....
gi 449099969 161 WPQVALFAQEIARL 174
Cdd:COG4635  161 WDAVRAFAREFAAL 174
Flavodoxin_5 pfam12724
Flavodoxin domain; This is a family of flavodoxins. Flavodoxins are electron transfer proteins ...
 4-153 1.12e-70

Flavodoxin domain; This is a family of flavodoxins. Flavodoxins are electron transfer proteins that carry a molecule of non-covalently bound FMN.


Pssm-ID: 463681 [Multi-domain]  Cd Length: 144  Bit Score: 210.20  E-value: 1.12e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449099969    4 LILFSTRDGQTREIAFYIASQLQEMGEAVDVVNLHraEAPDWTQYKKVVIGASIRYGHFHPTLDAFVKQHQQALNALPGA 83
Cdd:pfam12724   1 LILYSSRDGQTKKIAERIAEELREEGELVDVEDVE--AGEDLSSYDAVVIGASIYYGKHLPELRQFVTKHRDELSSKPVA 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 449099969   84 FFSVNLVARKPEKrtpqtNSYTRKFLLNSP-WQPDRCAVFAGALRYPRYRWFDRFMIRLIMKMTGGETDTS 153
Cdd:pfam12724  79 FFSVNLTARKPEK-----NPYMRKFLLKSLlWQPKLVGVFAGALDYPRYGFFDRLMIRLIMKMTKGPTDTD 144
 
Name Accession Description Interval E-value
hemG PRK11104
menaquinone-dependent protoporphyrinogen IX dehydrogenase;
1-177 4.60e-129

menaquinone-dependent protoporphyrinogen IX dehydrogenase;


Pssm-ID: 182966  Cd Length: 177  Bit Score: 358.89  E-value: 4.60e-129
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449099969   1 MKTLILFSTRDGQTREIAFYIASQLQEmGEAVDVVNLHRAEAPDWTQYKKVVIGASIRYGHFHPTLDAFVKQHQQALNAL 80
Cdd:PRK11104   1 MKTLILYSSRDGQTRKIASYIASELKE-GIQCDVVNLHRIEEPDLSDYDRVVIGASIRYGHFHSALYKFVKKHATQLNQM 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449099969  81 PGAFFSVNLVARKPEKRTPQTNSYTRKFLLNSPWQPDRCAVFAGALRYPRYRWFDRFMIRLIMKMTGGETDTSKEVVYTD 160
Cdd:PRK11104  80 PSAFFSVNLTARKPEKRTPQTNSYARKFLMNSPWQPDLCAVFAGALRYPRYRWFDRFMIKLIMKMTGGETDTSKEVEYTD 159

                        170
                 ....*....|....*..
gi 449099969 161 WPQVALFAQEIARLSRD 177
Cdd:PRK11104 160 WEQVANFAREFAQLTDK 176
HemG COG4635
Protoporphyrinogen IX oxidase, menaquinone-dependent (flavodoxin domain) [Coenzyme transport ...
 1-174 2.09e-105

Protoporphyrinogen IX oxidase, menaquinone-dependent (flavodoxin domain) [Coenzyme transport and metabolism];


Pssm-ID: 443673  Cd Length: 179  Bit Score: 299.50  E-value: 2.09e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449099969   1 MKTLILFSTRDGQTREIAFYIASQLQEMGEAVDVVNLHRAEAPDWTQYKKVVIGASIRYGHFHPTLDAFVKQHQQALNAL 80
Cdd:COG4635    1 MKVLILYASRDGQTRKIAERIAEVLREAGHDVDLVDLEDAPDLDLAGYDAVVIGASIRYGKWLPEAVRFVRRHRDALAAR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449099969  81 PGAFFSVNLVARKPEKRTPQTNSYTRKFLLNSPWQPDRCAVFAGALRYPRYRWFDRFMIRLIMKMTGGETDTSKEVVYTD 160
Cdd:COG4635   81 PVAFFSVSLTARKPEKRTPETNAYLRKFLAKTGWQPDLVAVFAGALDYPRYGFFDRLMIRLIMKMTGGETDTSRDGEYTD 160

                        170
                 ....*....|....
gi 449099969 161 WPQVALFAQEIARL 174
Cdd:COG4635  161 WDAVRAFAREFAAL 174
Flavodoxin_5 pfam12724
Flavodoxin domain; This is a family of flavodoxins. Flavodoxins are electron transfer proteins ...
 4-153 1.12e-70

Flavodoxin domain; This is a family of flavodoxins. Flavodoxins are electron transfer proteins that carry a molecule of non-covalently bound FMN.


Pssm-ID: 463681 [Multi-domain]  Cd Length: 144  Bit Score: 210.20  E-value: 1.12e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449099969    4 LILFSTRDGQTREIAFYIASQLQEMGEAVDVVNLHraEAPDWTQYKKVVIGASIRYGHFHPTLDAFVKQHQQALNALPGA 83
Cdd:pfam12724   1 LILYSSRDGQTKKIAERIAEELREEGELVDVEDVE--AGEDLSSYDAVVIGASIYYGKHLPELRQFVTKHRDELSSKPVA 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 449099969   84 FFSVNLVARKPEKrtpqtNSYTRKFLLNSP-WQPDRCAVFAGALRYPRYRWFDRFMIRLIMKMTGGETDTS 153
Cdd:pfam12724  79 FFSVNLTARKPEK-----NPYMRKFLLKSLlWQPKLVGVFAGALDYPRYGFFDRLMIRLIMKMTKGPTDTD 144
FldA COG0716
Flavodoxin [Energy production and conversion]; Flavodoxin is part of the Pathway/BioSystem: ...
 3-85 3.06e-12

Flavodoxin [Energy production and conversion]; Flavodoxin is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440480 [Multi-domain]  Cd Length: 135  Bit Score: 60.69  E-value: 3.06e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449099969   3 TLILFSTRDGQTREIAFYIASQLQEMGeaVDVVNLHRAEAPDWTQYKKVVIGASIRYGHFHPTLDAFVKQHQQALNALPG 82
Cdd:COG0716    1 ILIVYGSTTGNTEKVAEAIAEALGAAG--VDLFEIEDADLDDLEDYDLLILGTPTWAGELPDDWEDFLEELKEDLSGKKV 78


                 ...
gi 449099969  83 AFF 85
Cdd:COG0716   79 ALF 81
PRK06703 PRK06703
flavodoxin; Provisional
 1-54 4.20e-05

flavodoxin; Provisional


Pssm-ID: 235854 [Multi-domain]  Cd Length: 151  Bit Score: 41.67  E-value: 4.20e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 449099969   1 MKTLILFSTRDGQTREIAFYIASQLQEMGEAVDVVNLHRAEAPDWTQYKKVVIG 54
Cdd:PRK06703   2 AKILIAYASMSGNTEDIADLIKVSLDAFDHEVVLQEMDGMDAEELLAYDGIILG 55
PRK09271 PRK09271
flavodoxin; Provisional
 1-72 1.68e-04

flavodoxin; Provisional


Pssm-ID: 181744  Cd Length: 160  Bit Score: 40.17  E-value: 1.68e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 449099969   1 MKTLILFSTRDGQTREIAFYIASQLQEMGEAVDVVNLH---RAEAP-DWTQYKKVVIGA-SIRYGHFHPTLDAFVKQ 72
Cdd:PRK09271   1 MRILLAYASLSGNTREVAREIEERCEEAGHEVDWVETDvqtLAEYPlDPEDYDLYLLGTwTDNAGRTPPEMKRFIAE 77
Flavodoxin_1 pfam00258
Flavodoxin;
5-56 5.04e-04

Flavodoxin;


Pssm-ID: 425562 [Multi-domain]  Cd Length: 142  Bit Score: 38.50  E-value: 5.04e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 449099969    5 ILFSTRDGQTREIAFYIASQLQEMGEAVDVVNLHRAEAPDW--TQYKKVVIGAS 56
Cdd:pfam00258   1 IFYGSQTGNTEKLAEAIAEGLGEAGFEVDVVDLDDVDETLSeiEEEDLLLVVVS 54
NorV COG0426
Flavorubredoxin [Energy production and conversion];
2-69 5.46e-04

Flavorubredoxin [Energy production and conversion];


Pssm-ID: 440195 [Multi-domain]  Cd Length: 390  Bit Score: 39.43  E-value: 5.46e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 449099969   2 KTLILFSTRDGQTREIAFYIASQLQEMGEAVDVVNLHRAE----APDWTQYKKVVIGASIRYGHFHPTLDAF 69
Cdd:COG0426  248 KVVIVYASMYGNTEKMAEAIAEGLTEEGVKVKLYDLEKTDpseiITEIFDAKGIVIGSPTYNGGAFPPIADL 319
PRK09267 PRK09267
flavodoxin FldA; Validated
 1-56 6.40e-04

flavodoxin FldA; Validated


Pssm-ID: 236439 [Multi-domain]  Cd Length: 169  Bit Score: 38.66  E-value: 6.40e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 449099969   1 MKTLILFSTRDGQTREIAFYIASQLQemGEAVDVVNLHRAEAPDWTQYKKVVIGAS 56
Cdd:PRK09267   2 AKIGIFFGSDTGNTEDIAKMIQKKLG--KDVADVVDIAKASKEDFEAYDLLILGIP 55
PRK06242 PRK06242
flavodoxin; Provisional
 1-72 2.35e-03

flavodoxin; Provisional


Pssm-ID: 180484 [Multi-domain]  Cd Length: 150  Bit Score: 36.82  E-value: 2.35e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 449099969   1 MKTLILF-STRDGQTREIAFYIASQLQemgeaVDVVNLHRAEAPDWTQYKKVVIGASIRYGHFHPTLDAFVKQ 72
Cdd:PRK06242   1 MKALIVYaSVHHGNTEKIAKAIAEVLD-----AEVIDPGDVNPEDLSEYDLIGFGSGIYFGKFHKSLLKLIEK 68
PRK06756 PRK06756
flavodoxin; Provisional
 1-55 3.00e-03

flavodoxin; Provisional


Pssm-ID: 168663 [Multi-domain]  Cd Length: 148  Bit Score: 36.40  E-value: 3.00e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 449099969   1 MKTLILFSTRDGQTREIAFYIASQLQEMGEAVDVVNLHRA-EAPDWTQYKKVVIGA 55
Cdd:PRK06756   2 SKLVMIFASMSGNTEEMADHIAGVIRETENEIEVIDIMDSpEASILEQYDGIILGA 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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