NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|449022560|gb|AGE77723|]
View 

petrobactin biosynthesis protein AsbB [Bacillus thuringiensis serovar kurstaki str. HD73]

Protein Classification

IucA/IucC family siderophore biosynthesis protein( domain architecture ID 1004190)

IucA/IucC family siderophore biosynthesis protein similar to Klebsiella pneumoniae Aerobactin Synthetase IucA that catalyzes the condensation of citrate and hydroxylamine, serving as a surrogate nucleophile, to produce the corresponding citryl hydroxamate, PPi, and AMP

Gene Ontology:  GO:0019290

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
IucA super family cl34746
Siderophore synthetase component IucA/IucC/SbnC [Inorganic ion transport and metabolism];
22-205 2.58e-44

Siderophore synthetase component IucA/IucC/SbnC [Inorganic ion transport and metabolism];


The actual alignment was detected with superfamily member COG4264:

Pssm-ID: 443406 [Multi-domain]  Cd Length: 590  Bit Score: 155.10  E-value: 2.58e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449022560  22 VRRRVLRQLVESLIYEGIITPVRIEKEEQ---LLFLIQgLDEEGksVTYKCYGRERMTFGRISLD-SLIVRVQDEQQEIQ 97
Cdd:COG4264    9 ANRALLRKLLNELLRERLLAPEPEGELEDdggGVYRLP-LPAGG--VEYRFPARRRSAFGRHRFDpGSIYRTEDGAWRPL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449022560  98 SVSQFLEEVFRVTSVEQAKLDSFIHELEQTIFKDTIAQYERNNKRE--YTQKSYDEFESHLIDGHPYHPSYKARVGFQYR 175
Cdd:COG4264   86 DALQLLALLLEELGIDDETLAELLEELLNSLANDALALAHRRLSAAdlAAALDFIELEQALTEGHPLHPAPKSRIGFSAE 165

                        170       180       190
                 ....*....|....*....|....*....|
gi 449022560 176 DNFQYGYEFMQPIKLIWIAAHKNYATVGYV 205
Cdd:COG4264  166 DYRRYAPEFGGPFRLHWLAVHRDLARFGSA 195
 
Name Accession Description Interval E-value
IucA COG4264
Siderophore synthetase component IucA/IucC/SbnC [Inorganic ion transport and metabolism];
22-205 2.58e-44

Siderophore synthetase component IucA/IucC/SbnC [Inorganic ion transport and metabolism];


Pssm-ID: 443406 [Multi-domain]  Cd Length: 590  Bit Score: 155.10  E-value: 2.58e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449022560  22 VRRRVLRQLVESLIYEGIITPVRIEKEEQ---LLFLIQgLDEEGksVTYKCYGRERMTFGRISLD-SLIVRVQDEQQEIQ 97
Cdd:COG4264    9 ANRALLRKLLNELLRERLLAPEPEGELEDdggGVYRLP-LPAGG--VEYRFPARRRSAFGRHRFDpGSIYRTEDGAWRPL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449022560  98 SVSQFLEEVFRVTSVEQAKLDSFIHELEQTIFKDTIAQYERNNKRE--YTQKSYDEFESHLIDGHPYHPSYKARVGFQYR 175
Cdd:COG4264   86 DALQLLALLLEELGIDDETLAELLEELLNSLANDALALAHRRLSAAdlAAALDFIELEQALTEGHPLHPAPKSRIGFSAE 165

                        170       180       190
                 ....*....|....*....|....*....|
gi 449022560 176 DNFQYGYEFMQPIKLIWIAAHKNYATVGYV 205
Cdd:COG4264  166 DYRRYAPEFGGPFRLHWLAVHRDLARFGSA 195
IucA_IucC pfam04183
IucA / IucC family; IucA and IucC catalyze discrete steps in biosynthesis of the siderophore ...
 148-202 2.19e-22

IucA / IucC family; IucA and IucC catalyze discrete steps in biosynthesis of the siderophore aerobactin from N epsilon-acetyl-N epsilon-hydroxylysine and citrate. This family represents the N-terminal region. The C-terminal region appears to be related to iron transporter proteins.


Pssm-ID: 461213 [Multi-domain]  Cd Length: 210  Bit Score: 89.93  E-value: 2.19e-22
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 449022560  148 SYDEFESHLIDGHPYHPSYKARVGFQYRDNFQYGYEFMQPIKLIWIAAHKNYATV 202
Cdd:pfam04183   1 DFLELEQSLLEGHPFHPAPKSRLGFSEEDYRAYAPEFGGPFPLRWLAVHRDLARV 55
 
Name Accession Description Interval E-value
IucA COG4264
Siderophore synthetase component IucA/IucC/SbnC [Inorganic ion transport and metabolism];
22-205 2.58e-44

Siderophore synthetase component IucA/IucC/SbnC [Inorganic ion transport and metabolism];


Pssm-ID: 443406 [Multi-domain]  Cd Length: 590  Bit Score: 155.10  E-value: 2.58e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449022560  22 VRRRVLRQLVESLIYEGIITPVRIEKEEQ---LLFLIQgLDEEGksVTYKCYGRERMTFGRISLD-SLIVRVQDEQQEIQ 97
Cdd:COG4264    9 ANRALLRKLLNELLRERLLAPEPEGELEDdggGVYRLP-LPAGG--VEYRFPARRRSAFGRHRFDpGSIYRTEDGAWRPL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449022560  98 SVSQFLEEVFRVTSVEQAKLDSFIHELEQTIFKDTIAQYERNNKRE--YTQKSYDEFESHLIDGHPYHPSYKARVGFQYR 175
Cdd:COG4264   86 DALQLLALLLEELGIDDETLAELLEELLNSLANDALALAHRRLSAAdlAAALDFIELEQALTEGHPLHPAPKSRIGFSAE 165

                        170       180       190
                 ....*....|....*....|....*....|
gi 449022560 176 DNFQYGYEFMQPIKLIWIAAHKNYATVGYV 205
Cdd:COG4264  166 DYRRYAPEFGGPFRLHWLAVHRDLARFGSA 195
IucA_IucC pfam04183
IucA / IucC family; IucA and IucC catalyze discrete steps in biosynthesis of the siderophore ...
 148-202 2.19e-22

IucA / IucC family; IucA and IucC catalyze discrete steps in biosynthesis of the siderophore aerobactin from N epsilon-acetyl-N epsilon-hydroxylysine and citrate. This family represents the N-terminal region. The C-terminal region appears to be related to iron transporter proteins.


Pssm-ID: 461213 [Multi-domain]  Cd Length: 210  Bit Score: 89.93  E-value: 2.19e-22
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 449022560  148 SYDEFESHLIDGHPYHPSYKARVGFQYRDNFQYGYEFMQPIKLIWIAAHKNYATV 202
Cdd:pfam04183   1 DFLELEQSLLEGHPFHPAPKSRLGFSEEDYRAYAPEFGGPFPLRWLAVHRDLARV 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH