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Conserved domains on  [gi|407292567|gb|AFT96879|]
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family 2 glycosyl transferase [Alteromonas macleodii str. 'Balearic Sea AD45']

Protein Classification

glycosyltransferase( domain architecture ID 11421621)

bifunctional glycosyltransferase containing N-terminal family 2 and C-terminal family 4 glycosyltransferase domains, catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds

CAZY:  GT2|GT4
EC:  2.4.-.-
Gene Ontology:  GO:0016757|GO:0006486
PubMed:  12691742|9445404|16037492|10521532
SCOP:  3000077|3001586

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 569-921 4.99e-38

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


:

Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 146.14  E-value: 4.99e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 569 HVALFGHAVSETVFGAERSLVDIAEAMQKANISITLFLPSCSNITYIEElkQFVRKIVFLPLPWANGReepIQPVAQYLE 648
Cdd:cd03801    1 KILLLSPELPPPVGGAERHVRELARALAARGHDVTVLTPADPGEPPEEL--EDGVIVPLLPSLAALLR---ARRLLRELR 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 649 SDFLHCGYDCVYVNTLTLIEPLSAAKKA-GIPMVMHVRELVEFDNDLADLLRESPQRTHARVIATSDYFIANSEETARWI 727
Cdd:cd03801   76 PLLRLRKFDVVHAHGLLAALLAALLALLlGAPLVVTLHGAEPGRLLLLLAAERRLLARAEALLRRADAVIAVSEALRDEL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 728 NE-----PERTTVIYNCVDTSPSQNSM------PSGALKICMLSSNVKKKGVEDFFE-VASLCKEASNIQFTIYG---PI 792
Cdd:cd03801  156 RAlggipPEKIVVIPNGVDLERFSPPLrrklgiPPDRPVLLFVGRLSPRKGVDLLLEaLAKLLRRGPDVRLVIVGgdgPL 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 793 TNEVIMAAKRFGDaNITIAGYVEKP--KEAMAEHHIVLALSHFkESFGRTVAEAMSLGRVVVGYDWGAVNELV-DKQSGI 869
Cdd:cd03801  236 RAELEELELGLGD-RVRFLGFVPDEelPALYAAADVFVLPSRY-EGFGLVVLEAMAAGLPVVATDVGGLPEVVeDGEGGL 313

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 407292567 870 LVDYKSTEKIVDAILDLNCNPKLVASMGNCAAKRAKELFSRDTFGKKLVNQI 921
Cdd:cd03801  314 VVPPDDVEALADALLRLLADPELRARLGRAARERVAERFSWERVAERLLDLY 365
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 213-397 7.61e-33

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 126.36  E-value: 7.61e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 213 KVSIIVPVFNAEKVISTSINSLLNQSWKNIEIIAVDDASTDNSYTELKRLYGGIDRVRIIKNNKNKGAYATRNLGMTLAS 292
Cdd:COG0463    3 LVSVVIPTYNEEEYLEEALESLLAQTYPDFEIIVVDDGSTDGTAEILRELAAKDPRIRVIRLERNRGKGAARNAGLAAAR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 293 GNFLTVMDADDWAHPQKIEKQVIPL-------LFNRSLKGTVSHWVRCTEDLEFSRLRVGNSWVHRNVSSLLVRKDVVAS 365
Cdd:COG0463   83 GDYIAFLDADDQLDPEKLEELVAALeegpadlVYGSRLIREGESDLRRLGSRLFNLVRLLTNLPDSTSGFRLFRREVLEE 162

                        170       180       190
                 ....*....|....*....|....*....|..
gi 407292567 366 LgGWDEvKVNADTEFYERCLAKFGKAAIKEVM 397
Cdd:COG0463  163 L-GFDE-GFLEDTELLRALRHGFRIAEVPVRY 192
 
Name Accession Description Interval E-value
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 569-921 4.99e-38

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 146.14  E-value: 4.99e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 569 HVALFGHAVSETVFGAERSLVDIAEAMQKANISITLFLPSCSNITYIEElkQFVRKIVFLPLPWANGReepIQPVAQYLE 648
Cdd:cd03801    1 KILLLSPELPPPVGGAERHVRELARALAARGHDVTVLTPADPGEPPEEL--EDGVIVPLLPSLAALLR---ARRLLRELR 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 649 SDFLHCGYDCVYVNTLTLIEPLSAAKKA-GIPMVMHVRELVEFDNDLADLLRESPQRTHARVIATSDYFIANSEETARWI 727
Cdd:cd03801   76 PLLRLRKFDVVHAHGLLAALLAALLALLlGAPLVVTLHGAEPGRLLLLLAAERRLLARAEALLRRADAVIAVSEALRDEL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 728 NE-----PERTTVIYNCVDTSPSQNSM------PSGALKICMLSSNVKKKGVEDFFE-VASLCKEASNIQFTIYG---PI 792
Cdd:cd03801  156 RAlggipPEKIVVIPNGVDLERFSPPLrrklgiPPDRPVLLFVGRLSPRKGVDLLLEaLAKLLRRGPDVRLVIVGgdgPL 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 793 TNEVIMAAKRFGDaNITIAGYVEKP--KEAMAEHHIVLALSHFkESFGRTVAEAMSLGRVVVGYDWGAVNELV-DKQSGI 869
Cdd:cd03801  236 RAELEELELGLGD-RVRFLGFVPDEelPALYAAADVFVLPSRY-EGFGLVVLEAMAAGLPVVATDVGGLPEVVeDGEGGL 313

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 407292567 870 LVDYKSTEKIVDAILDLNCNPKLVASMGNCAAKRAKELFSRDTFGKKLVNQI 921
Cdd:cd03801  314 VVPPDDVEALADALLRLLADPELRARLGRAARERVAERFSWERVAERLLDLY 365
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 213-397 7.61e-33

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 126.36  E-value: 7.61e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 213 KVSIIVPVFNAEKVISTSINSLLNQSWKNIEIIAVDDASTDNSYTELKRLYGGIDRVRIIKNNKNKGAYATRNLGMTLAS 292
Cdd:COG0463    3 LVSVVIPTYNEEEYLEEALESLLAQTYPDFEIIVVDDGSTDGTAEILRELAAKDPRIRVIRLERNRGKGAARNAGLAAAR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 293 GNFLTVMDADDWAHPQKIEKQVIPL-------LFNRSLKGTVSHWVRCTEDLEFSRLRVGNSWVHRNVSSLLVRKDVVAS 365
Cdd:COG0463   83 GDYIAFLDADDQLDPEKLEELVAALeegpadlVYGSRLIREGESDLRRLGSRLFNLVRLLTNLPDSTSGFRLFRREVLEE 162

                        170       180       190
                 ....*....|....*....|....*....|..
gi 407292567 366 LgGWDEvKVNADTEFYERCLAKFGKAAIKEVM 397
Cdd:COG0463  163 L-GFDE-GFLEDTELLRALRHGFRIAEVPVRY 192
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 216-393 1.14e-32

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 124.16  E-value: 1.14e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 216 IIVPVFNAEKVISTSINSLLNQSWKNIEIIAVDDASTDNSYTELKRLYGGIDRVRIIKNNKNKGAYATRNLGMTLASGNF 295
Cdd:cd00761    1 VIIPAYNEEPYLERCLESLLAQTYPNFEVIVVDDGSTDGTLEILEEYAKKDPRVIRVINEENQGLAAARNAGLKAARGEY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 296 LTVMDADDWAHPQKIEKQVIPLLFNRSLKGTVSHWvrctedlefsrlrvgnswvhrnvsSLLVRKDVVASLGGWDEVKVN 375
Cdd:cd00761   81 ILFLDADDLLLPDWLERLVAELLADPEADAVGGPG------------------------NLLFRRELLEEIGGFDEALLS 136

                        170       180
                 ....*....|....*....|
gi 407292567 376 A--DTEFYERCLAKFGKAAI 393
Cdd:cd00761  137 GeeDDDFLLRLLRGGKVAFR 156
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 215-314 7.79e-31

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 119.04  E-value: 7.79e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567  215 SIIVPVFNAEKVISTSINSLLNQSWKNIEIIAVDDASTDNSYTELKRLYGGIDRVRIIKNNKNKGAYATRNLGMTLASGN 294
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLLNQTYPNFEIIVVDDGSTDGTVEIAEEYAKKDPRVRVIRLPENRGKAGARNAGLRAATGD 80

                          90       100
                  ....*....|....*....|
gi 407292567  295 FLTVMDADDWAHPQKIEKQV 314
Cdd:pfam00535  81 YIAFLDADDEVPPDWLEKLV 100
Glyco_trans_1_4 pfam13692
Glycosyl transferases group 1;
762-886 1.12e-20

Glycosyl transferases group 1;


Pssm-ID: 463957 [Multi-domain]  Cd Length: 138  Bit Score: 89.11  E-value: 1.12e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567  762 NVKKKGVEDFFE-VASLCKEASNIQFTIYGPITNEVIMAAKRFGDANITIAGYVEKPKEAMAEHHIVLALSHFkESFGRT 840
Cdd:pfam13692  11 HPNVKGVDYLLEaVPLLRKRDNDVRLVIVGDGPEEELEELAAGLEDRVIFTGFVEDLAELLAAADVFVLPSLY-EGFGLK 89

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 407292567  841 VAEAMSLGRVVVGYDWGAVNELVDKQSGILVDYKSTEKIVDAILDL 886
Cdd:pfam13692  90 LLEAMAAGLPVVATDVGGIPELVDGENGLLVPPGDPEALAEAILRL 135
PRK10073 PRK10073
putative glycosyl transferase; Provisional
 210-308 1.46e-20

putative glycosyl transferase; Provisional


Pssm-ID: 182223 [Multi-domain]  Cd Length: 328  Bit Score: 93.96  E-value: 1.46e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 210 SKSKVSIIVPVFNAEKVISTSINSLLNQSWKNIEIIAVDDASTDNSYTELKRLYGGIDRVRIIKnNKNKGAYATRNLGMT 289
Cdd:PRK10073   4 STPKLSIIIPLYNAGKDFRAFMESLIAQTWTALEIIIVNDGSTDNSVEIAKHYAENYPHVRLLH-QANAGVSVARNTGLA 82

                         90
                 ....*....|....*....
gi 407292567 290 LASGNFLTVMDADDWAHPQ 308
Cdd:PRK10073  83 VATGKYVAFPDADDVVYPT 101
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 820-919 1.10e-17

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 80.03  E-value: 1.10e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 820 AMAEHHIVLALSHFkESFGRTVAEAMSLGRVVVGYDWGAVNELV-DKQSGILVDYKSTEKIVDAILDLNCNPKLVASMGN 898
Cdd:COG0438   17 LLAAADVFVLPSRS-EGFGLVLLEAMAAGLPVIATDVGGLPEVIeDGETGLLVPPGDPEALAEAILRLLEDPELRRRLGE 95

                         90       100
                 ....*....|....*....|.
gi 407292567 899 CAAKRAKELFSRDTFGKKLVN 919
Cdd:COG0438   96 AARERAEERFSWEAIAERLLA 116
thiol_BshA TIGR03999
N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Members of this protein family are BshA, ...
 643-920 1.23e-07

N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Members of this protein family are BshA, a glycosyltransferase required for bacillithiol biosynthesis. This enzyme combines UDP-GlcNAc and L-malate to form N-acetyl-alpha-D-glucosaminyl L-malate synthase. Bacillithiol is a low-molecular-weight thiol, an analog of glutathione and mycothiol, and is found largely in the Firmicutes. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs]


Pssm-ID: 274914 [Multi-domain]  Cd Length: 374  Bit Score: 54.92  E-value: 1.23e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567  643 VAQYLESDFLHCGYDCVYVNTLTLIEPLSAAKKAGIPMV--MHVRE--LVEFDNDLADLLRESPQRTHArVIATSDYFIa 718
Cdd:TIGR03999  79 VAKEEKLDLLHVHYAIPHAIAAYLARQMLGKEGIDIPIVttLHGTDitLVGADPSFKPAVRFSIEKSDG-VTAVSESLK- 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567  719 nsEETARWINEPERTTVIYNCVDTS---PSQNSMPSGAL------KICMLSSNVKK-KGVEDFFEV-ASLCKEASNIQFT 787
Cdd:TIGR03999 157 --EETYELFDIDKPIEVIPNFVDTDryrRKNDPALKRKLgapedeKVLIHISNFRPvKRVEDVIEVfARVQQEVPAKLLL 234

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567  788 I-YGPITNEVIMAAKRFGDAN-ITIAGYVEKPKEAMAEHHIVLALSHfKESFGRTVAEAMSLGRVVVGYDWGAVNELV-D 864
Cdd:TIGR03999 235 VgDGPERSPAEQLVRELGLTDrVLFLGKQDDVAELLSISDLFLLPSE-KESFGLAALEAMACGVPVIASNAGGIPEVVeH 313

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 407292567  865 KQSGILVDYKSTEKIVDAILDLNCNPKLVASMGNCAAKRAKELFSRdtfgKKLVNQ 920
Cdd:TIGR03999 314 GVTGFLCDVGDVETMAEYAISLLEDEELLQRFSAAARERAKERFDS----EKIVPQ 365
PRK15484 PRK15484
lipopolysaccharide N-acetylglucosaminyltransferase;
777-921 2.51e-04

lipopolysaccharide N-acetylglucosaminyltransferase;


Pssm-ID: 185381 [Multi-domain]  Cd Length: 380  Bit Score: 44.40  E-value: 2.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 777 LCKEASNIQFTIYGPITN-----------EVIMAAKRFGDANITIAGyveKPKEAMAEHH----IVLALSHFKESFGRTV 841
Cdd:PRK15484 218 LATAHSNLKLVVVGDPTAsskgekaayqkKVLEAAKRIGDRCIMLGG---QPPEKMHNYYpladLVVVPSQVEEAFCMVA 294

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 842 AEAMSLGRVVVGYDWGAVNELV-DKQSGI-LVDYKSTEKIVDAILDLNCNPKLvASMGNCAAKRAKELFSRDTFGKKLVN 919
Cdd:PRK15484 295 VEAMAAGKPVLASTKGGITEFVlEGITGYhLAEPMTSDSIISDINRTLADPEL-TQIAEQAKDFVFSKYSWEGVTQRFEE 373


                 ..
gi 407292567 920 QI 921
Cdd:PRK15484 374 QI 375
 
Name Accession Description Interval E-value
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 569-921 4.99e-38

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 146.14  E-value: 4.99e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 569 HVALFGHAVSETVFGAERSLVDIAEAMQKANISITLFLPSCSNITYIEElkQFVRKIVFLPLPWANGReepIQPVAQYLE 648
Cdd:cd03801    1 KILLLSPELPPPVGGAERHVRELARALAARGHDVTVLTPADPGEPPEEL--EDGVIVPLLPSLAALLR---ARRLLRELR 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 649 SDFLHCGYDCVYVNTLTLIEPLSAAKKA-GIPMVMHVRELVEFDNDLADLLRESPQRTHARVIATSDYFIANSEETARWI 727
Cdd:cd03801   76 PLLRLRKFDVVHAHGLLAALLAALLALLlGAPLVVTLHGAEPGRLLLLLAAERRLLARAEALLRRADAVIAVSEALRDEL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 728 NE-----PERTTVIYNCVDTSPSQNSM------PSGALKICMLSSNVKKKGVEDFFE-VASLCKEASNIQFTIYG---PI 792
Cdd:cd03801  156 RAlggipPEKIVVIPNGVDLERFSPPLrrklgiPPDRPVLLFVGRLSPRKGVDLLLEaLAKLLRRGPDVRLVIVGgdgPL 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 793 TNEVIMAAKRFGDaNITIAGYVEKP--KEAMAEHHIVLALSHFkESFGRTVAEAMSLGRVVVGYDWGAVNELV-DKQSGI 869
Cdd:cd03801  236 RAELEELELGLGD-RVRFLGFVPDEelPALYAAADVFVLPSRY-EGFGLVVLEAMAAGLPVVATDVGGLPEVVeDGEGGL 313

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 407292567 870 LVDYKSTEKIVDAILDLNCNPKLVASMGNCAAKRAKELFSRDTFGKKLVNQI 921
Cdd:cd03801  314 VVPPDDVEALADALLRLLADPELRARLGRAARERVAERFSWERVAERLLDLY 365
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 213-397 7.61e-33

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 126.36  E-value: 7.61e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 213 KVSIIVPVFNAEKVISTSINSLLNQSWKNIEIIAVDDASTDNSYTELKRLYGGIDRVRIIKNNKNKGAYATRNLGMTLAS 292
Cdd:COG0463    3 LVSVVIPTYNEEEYLEEALESLLAQTYPDFEIIVVDDGSTDGTAEILRELAAKDPRIRVIRLERNRGKGAARNAGLAAAR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 293 GNFLTVMDADDWAHPQKIEKQVIPL-------LFNRSLKGTVSHWVRCTEDLEFSRLRVGNSWVHRNVSSLLVRKDVVAS 365
Cdd:COG0463   83 GDYIAFLDADDQLDPEKLEELVAALeegpadlVYGSRLIREGESDLRRLGSRLFNLVRLLTNLPDSTSGFRLFRREVLEE 162

                        170       180       190
                 ....*....|....*....|....*....|..
gi 407292567 366 LgGWDEvKVNADTEFYERCLAKFGKAAIKEVM 397
Cdd:COG0463  163 L-GFDE-GFLEDTELLRALRHGFRIAEVPVRY 192
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 216-393 1.14e-32

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 124.16  E-value: 1.14e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 216 IIVPVFNAEKVISTSINSLLNQSWKNIEIIAVDDASTDNSYTELKRLYGGIDRVRIIKNNKNKGAYATRNLGMTLASGNF 295
Cdd:cd00761    1 VIIPAYNEEPYLERCLESLLAQTYPNFEVIVVDDGSTDGTLEILEEYAKKDPRVIRVINEENQGLAAARNAGLKAARGEY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 296 LTVMDADDWAHPQKIEKQVIPLLFNRSLKGTVSHWvrctedlefsrlrvgnswvhrnvsSLLVRKDVVASLGGWDEVKVN 375
Cdd:cd00761   81 ILFLDADDLLLPDWLERLVAELLADPEADAVGGPG------------------------NLLFRRELLEEIGGFDEALLS 136

                        170       180
                 ....*....|....*....|
gi 407292567 376 A--DTEFYERCLAKFGKAAI 393
Cdd:cd00761  137 GeeDDDFLLRLLRGGKVAFR 156
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 215-314 7.79e-31

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 119.04  E-value: 7.79e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567  215 SIIVPVFNAEKVISTSINSLLNQSWKNIEIIAVDDASTDNSYTELKRLYGGIDRVRIIKNNKNKGAYATRNLGMTLASGN 294
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLLNQTYPNFEIIVVDDGSTDGTVEIAEEYAKKDPRVRVIRLPENRGKAGARNAGLRAATGD 80

                          90       100
                  ....*....|....*....|
gi 407292567  295 FLTVMDADDWAHPQKIEKQV 314
Cdd:pfam00535  81 YIAFLDADDEVPPDWLEKLV 100
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 213-387 5.15e-28

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 115.22  E-value: 5.15e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 213 KVSIIVPVFNAEKVISTSINSLLNQSW--KNIEIIAVDDASTDNSYTELKRLYGGIDRVRIIKNNKNKGAYATRNLGMTL 290
Cdd:COG1215   30 RVSVIIPAYNEEAVIEETLRSLLAQDYpkEKLEVIVVDDGSTDETAEIARELAAEYPRVRVIERPENGGKAAALNAGLKA 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 291 ASGNFLTVMDADDWAHPQKIEKQVIPllfnrslkgtvshwvrctedleFSRLRVGNswvhrNVSSLLVRKDVVASLGGWD 370
Cdd:COG1215  110 ARGDIVVFLDADTVLDPDWLRRLVAA----------------------FADPGVGA-----SGANLAFRREALEEVGGFD 162

                        170
                 ....*....|....*..
gi 407292567 371 EVKVNADTEFYERCLAK 387
Cdd:COG1215  163 EDTLGEDLDLSLRLLRA 179
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
210-371 4.99e-24

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 100.84  E-value: 4.99e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 210 SKSKVSIIVPVFNAEKVISTSINSLLNQSWKNIEIIAVDDASTDNSYTELKRLYGgiDRVRIIKNNKNKGAYATRNLGMT 289
Cdd:COG1216    1 MRPKVSVVIPTYNRPELLRRCLESLLAQTYPPFEVIVVDNGSTDGTAELLAALAF--PRVRVIRNPENLGFAAARNLGLR 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 290 LASGNFLTVMDADDWAHPQKIEKQVipllfnrslkgtvshwvrctedlefsrlrvgnswvhrNVSSLLVRKDVVASLGGW 369
Cdd:COG1216   79 AAGGDYLLFLDDDTVVEPDWLERLL-------------------------------------AAACLLIRREVFEEVGGF 121


                 ..
gi 407292567 370 DE 371
Cdd:COG1216  122 DE 123
GT4_CapM-like cd03808
capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This ...
 727-911 7.81e-22

capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides.


Pssm-ID: 340837 [Multi-domain]  Cd Length: 358  Bit Score: 98.05  E-value: 7.81e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 727 INEPERTTVIYNC-VDT---SPSQNSMPSGALKICMLSSNVKKKGVEDFFEVASLCKE-ASNIQFTIYGPI--TNEVIMA 799
Cdd:cd03808  159 IIKKKKTVLIPGSgVDLdrfQYSPESLPSEKVVFLFVARLLKDKGIDELIEAAKILKKkGPNVRFLLVGDGelENPSEIL 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 800 AKRFG-DANITIAGYVEKPKEAMAEHHIVLALSHFkESFGRTVAEAMSLGRVVVGYDWGAVNELV-DKQSGILVDYKSTE 877
Cdd:cd03808  239 IEKLGlEGRIEFLGFRSDVPELLAESDVFVLPSYR-EGLPRSLLEAMAAGRPVITTDVPGCRELViDGVNGFLVPPGDVE 317

                        170       180       190
                 ....*....|....*....|....*....|....
gi 407292567 878 KIVDAILDLNCNPKLVASMGNCAAKRAKELFSRD 911
Cdd:cd03808  318 ALADAIEKLIEDPELRKEMGEAARKRVEEKFDEE 351
GT4_WbuB-like cd03794
Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 ...
 656-918 5.23e-21

Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.


Pssm-ID: 340825 [Multi-domain]  Cd Length: 391  Bit Score: 96.26  E-value: 5.23e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 656 YDCVYVNTLTLIEPLSA---AKKAGIPMVMHVRELvEFDN--DLADLLRESPQRTHAR----VIATSDYFIANSEETARW 726
Cdd:cd03794   99 PDVIIAYSPPITLGLAAlllKKLRGAPFILDVRDL-WPESliALGVLKKGSLLKLLKKlerkLYRLADAIIVLSPGLKEY 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 727 INE----PERTTVIYNCVDTSPSQNSMPSGALK--------ICMLSSNV-KKKGVEDFFEVASLCKEASNIQFTIYG--P 791
Cdd:cd03794  178 LLRkgvpKEKIIVIPNWADLEEFKPPPKDELRKklglddkfVVVYAGNIgKAQGLETLLEAAERLKRRPDIRFLFVGdgD 257

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 792 ITNEVIMAAKRFGDANITIAGYVEKPK--EAMAEHHIVLALSHFKESFGRTVA----EAMSLGRVVVGYDWGAVNELV-D 864
Cdd:cd03794  258 EKERLKELAKARGLDNVTFLGRVPKEEvpELLSAADVGLVPLKDNPANRGSSPsklfEYMAAGKPILASDDGGSDLAVeI 337

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 407292567 865 KQSGILVDYKSTEKIVDAILDLNCNPKLVASMGNCAAKRAKELFSRDTFGKKLV 918
Cdd:cd03794  338 NGCGLVVEPGDPEALADAILELLDDPELRRAMGENGRELAEEKFSREKLADRLL 391
Glyco_trans_1_4 pfam13692
Glycosyl transferases group 1;
762-886 1.12e-20

Glycosyl transferases group 1;


Pssm-ID: 463957 [Multi-domain]  Cd Length: 138  Bit Score: 89.11  E-value: 1.12e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567  762 NVKKKGVEDFFE-VASLCKEASNIQFTIYGPITNEVIMAAKRFGDANITIAGYVEKPKEAMAEHHIVLALSHFkESFGRT 840
Cdd:pfam13692  11 HPNVKGVDYLLEaVPLLRKRDNDVRLVIVGDGPEEELEELAAGLEDRVIFTGFVEDLAELLAAADVFVLPSLY-EGFGLK 89

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 407292567  841 VAEAMSLGRVVVGYDWGAVNELVDKQSGILVDYKSTEKIVDAILDL 886
Cdd:pfam13692  90 LLEAMAAGLPVVATDVGGIPELVDGENGLLVPPGDPEALAEAILRL 135
PRK10073 PRK10073
putative glycosyl transferase; Provisional
 210-308 1.46e-20

putative glycosyl transferase; Provisional


Pssm-ID: 182223 [Multi-domain]  Cd Length: 328  Bit Score: 93.96  E-value: 1.46e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 210 SKSKVSIIVPVFNAEKVISTSINSLLNQSWKNIEIIAVDDASTDNSYTELKRLYGGIDRVRIIKnNKNKGAYATRNLGMT 289
Cdd:PRK10073   4 STPKLSIIIPLYNAGKDFRAFMESLIAQTWTALEIIIVNDGSTDNSVEIAKHYAENYPHVRLLH-QANAGVSVARNTGLA 82

                         90
                 ....*....|....*....
gi 407292567 290 LASGNFLTVMDADDWAHPQ 308
Cdd:PRK10073  83 VATGKYVAFPDADDVVYPT 101
GT4_WavL-like cd03819
Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 ...
 672-911 3.79e-20

Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core.


Pssm-ID: 340846 [Multi-domain]  Cd Length: 345  Bit Score: 92.80  E-value: 3.79e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 672 AAKKAGIPMVM--HVRELVEFDndladllresPQRTHARVIATSDYFIANSEETARWINE-----PERTTVIYNCVDTSP 744
Cdd:cd03819   94 ASRLTGVPLVTtvHGSYLATYH----------PKDFALAVRARGDRVIAVSELVRDHLIEalgvdPERIRVIPNGVDTDR 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 745 ----------SQNSMPSGALKICMLSSNVKKKGVEDFFEVASLCKEASNIQFTIYG--PITNEVIMAAKRFGDAN-ITIA 811
Cdd:cd03819  164 fppeaeaeerAQLGLPEGKPVVGYVGRLSPEKGWLLLVDAAAELKDEPDFRLLVAGdgPERDEIRRLVERLGLRDrVTFT 243

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 812 GYVEKPKEAMAEHHIVLALSHfKESFGRTVAEAMSLGRVVVGYDWGAVNELVDK-QSGILVDYKSTEKIVDAILDLNCNP 890
Cdd:cd03819  244 GFREDVPAALAASDVVVLPSL-HEEFGRVALEAMACGTPVVATDVGGAREIVVHgRTGLLVPPGDAEALADAIRAAKLLP 322

                        250       260
                 ....*....|....*....|...
gi 407292567 891 KLVASMGNCAA--KRAKELFSRD 911
Cdd:cd03819  323 EAREKLQAAAAltEAVRELLLRV 345
GT_2_WfgS_like cd06433
WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella ...
 215-414 1.36e-19

WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella dysenteriae WfeV are glycosyltransferase 2 family enzymes involved in O-antigen biosynthesis. GT-2 enzymes have GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133055 [Multi-domain]  Cd Length: 202  Bit Score: 87.99  E-value: 1.36e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 215 SIIVPVFNAEKVISTSINSLLNQSWKNIEIIAVDDASTDNSytelkrlyggidrVRIIKNNKNKGAYATR---------- 284
Cdd:cd06433    1 SIITPTYNQAETLEETIDSVLSQTYPNIEYIVIDGGSTDGT-------------VDIIKKYEDKITYWISepdkgiydam 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 285 NLGMTLASGNFLTVMDADDWAHPQKIEKQVIPLLFN------------RSLKGTVShWVRCTEDLEFSRLRVGNSWVHrn 352
Cdd:cd06433   68 NKGIALATGDIIGFLNSDDTLLPGALLAVVAAFAEHpevdvvygdvllVDENGRVI-GRRRPPPFLDKFLLYGMPICH-- 144

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 407292567 353 vSSLLVRKDVVASLGGWDEV-KVNADTEFYERCLAKFGKAAIkevmPDVPLSFGRTHASSLTQ 414
Cdd:cd06433  145 -QATFFRRSLFEKYGGFDESyRIAADYDLLLRLLLAGKIFKY----LPEVLAAFRLGGVSSTS 202
GT4_ExpE7-like cd03823
glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 ...
 583-896 2.01e-19

glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II).


Pssm-ID: 340850 [Multi-domain]  Cd Length: 357  Bit Score: 90.85  E-value: 2.01e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 583 GAERSLVDIAEAMQKANISITLFLPS--CSNITYIEELKQFVRKIVFLPLPWANGR--EEPIQP--------VAQYLEsD 650
Cdd:cd03823   16 GAEISVHDLAEALVAEGHEVAVLTAGvgPPGQATVARSVVRYRRAPDETLPLALKRrgYELFETynpglrrlLARLLE-D 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 651 FlhcGYDCVYVNTLTLI--EPLSAAKKAGIPMVMHVRelvefdndlaDLLRESPQrtHARVIATSDYFIANSEETA---- 724
Cdd:cd03823   95 F---RPDVVHTHNLSGLgaSLLDAARDLGIPVVHTLH----------DYWLLCPR--QFLFKKGGDAVLAPSRFTAnlhe 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 725 RWINEPERTTVIYNCVDTSPS---QNSMPSGALKICMLSSNVKKKGVEDFFEVASLCKeASNIQFTIYGPITNEviMAAK 801
Cdd:cd03823  160 ANGLFSARISVIPNAVEPDLApppRRRPGTERLRFGYIGRLTEEKGIDLLVEAFKRLP-REDIELVIAGHGPLS--DERQ 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 802 RFGDANITIAGYV--EKPKEAMAEHHIVLALSHFKESFGRTVAEAMSLGRVVVGYDWGAVNELV-DKQSGILVDYKSTEK 878
Cdd:cd03823  237 IEGGRRIAFLGRVptDDIKDFYEKIDVLVVPSIWPEPFGLVVREAIAAGLPVIASDLGGIAELIqPGVNGLLFAPGDAED 316

                        330
                 ....*....|....*...
gi 407292567 879 IVDAILDLNCNPKLVASM 896
Cdd:cd03823  317 LAAAMRRLLTDPALLERL 334
CESA_like cd06423
CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily ...
 216-371 8.76e-19

CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of Glucan.


Pssm-ID: 133045 [Multi-domain]  Cd Length: 180  Bit Score: 84.97  E-value: 8.76e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 216 IIVPVFNAEKVISTSINSLLNQSWKNIEIIAVDDASTDNSYTELKRLYG-GIDRVRIIKNNKNKG-AYATrNLGMTLASG 293
Cdd:cd06423    1 IIVPAYNEEAVIERTIESLLALDYPKLEVIVVDDGSTDDTLEILEELAAlYIRRVLVVRDKENGGkAGAL-NAGLRHAKG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 294 NFLTVMDADDWAHPQKIEKQVIPLLFNRSL---------KGTVSHWVRCTEDLEFSR---LRVGNSWVHRNVSSL----- 356
Cdd:cd06423   80 DIVVVLDADTILEPDALKRLVVPFFADPKVgavqgrvrvRNGSENLLTRLQAIEYLSifrLGRRAQSALGGVLVLsgafg 159

                        170
                 ....*....|....*
gi 407292567 357 LVRKDVVASLGGWDE 371
Cdd:cd06423  160 AFRREALREVGGWDE 174
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 820-919 1.10e-17

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 80.03  E-value: 1.10e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 820 AMAEHHIVLALSHFkESFGRTVAEAMSLGRVVVGYDWGAVNELV-DKQSGILVDYKSTEKIVDAILDLNCNPKLVASMGN 898
Cdd:COG0438   17 LLAAADVFVLPSRS-EGFGLVLLEAMAAGLPVIATDVGGLPEVIeDGETGLLVPPGDPEALAEAILRLLEDPELRRRLGE 95

                         90       100
                 ....*....|....*....|.
gi 407292567 899 CAAKRAKELFSRDTFGKKLVN 919
Cdd:COG0438   96 AARERAEERFSWEAIAERLLA 116
GT4_WbnK-like cd03807
Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 ...
 583-911 3.38e-17

Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis.


Pssm-ID: 340836 [Multi-domain]  Cd Length: 362  Bit Score: 84.29  E-value: 3.38e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 583 GAERSLVDIAEAMQKANISITLFlpSCSNI-TYIEELKQFVRKIVFLplpwanGREEPIQPVAQY-LESDFLHCGYDCVY 660
Cdd:cd03807   13 GAETMLLRLLEHMDKSRFEHVVI--SLTGDgVLGEELLAAGVPVVCL------GLSSGKDPGVLLrLAKLIRKRNPDVVH 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 661 V--NTLTLIEPLSAAKKAGIPMVMHVRELVEfdndladllresPQRTHARVIA-------TSDYFIANSEETARWINE-- 729
Cdd:cd03807   85 TwmYHADLIGGLAAKLAGGVKVIWSVRSSNI------------PQRLTRLVRKlclllskFSPATVANSSAVAEFHQEqg 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 730 --PERTTVIYNCVDT---SPSQNSMPSGALKICMLSSNV---------KKKGVEDFFEVASLCKEA-SNIQFTIYG--PI 792
Cdd:cd03807  153 yaKNKIVVIYNGIDLfklSPDDASRARARRRLGLAEDRRvigivgrlhPVKDHSDLLRAAALLVEThPDLRLLLVGrgPE 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 793 TNEVIMAAKRFG-DANITIAGYVEKPKEAMaEHHIVLALSHFKESFGRTVAEAMSLGRVVVGYDWGAVNELVDKQSGILV 871
Cdd:cd03807  233 RPNLERLLLELGlEDRVHLLGERSDVPALL-PAMDIFVLSSRTEGFPNALLEAMACGLPVVATDVGGAAELVDDGTGFLV 311

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 407292567 872 DYKSTEKIVDAILDLNCNPKLVASMGNCAAKRAKELFSRD 911
Cdd:cd03807  312 PAGDPQALADAIRALLEDPEKRARLGRAARERIANEFSID 351
GT4_WlbH-like cd03798
Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the ...
 673-917 8.20e-17

Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Staphylococcus aureus CapJ may be involved in capsule polysaccharide biosynthesis. WlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (band B), generates band A LPS.


Pssm-ID: 340828 [Multi-domain]  Cd Length: 376  Bit Score: 83.20  E-value: 8.20e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 673 AKKAGIPMV--MHVRELVEFDND--LADLLRESPQRThARVIATSDYFIansEETARWINEPERTTVIYNCVDT-----S 743
Cdd:cd03798  115 ARLYGVPYVvtEHGSDINVFPPRslLRKLLRWALRRA-ARVIAVSKALA---EELVALGVPRDRVDVIPNGVDParfqpE 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 744 PSQNSMPSGALKICMLSSNVKKKGVEDFFE-VASLCKEASNIQFTIYG-PITNEVI--MAAKRFGDANITIAGYVekPKE 819
Cdd:cd03798  191 DRGLGLPLDAFVILFVGRLIPRKGIDLLLEaFARLAKARPDVVLLIVGdGPLREALraLAEDLGLGDRVTFTGRL--PHE 268

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 820 AMAEHHI---VLALSHFKESFGRTVAEAMSLGRVVVGYDWGAVNELV-DKQSGILVDYKSTEKIVDAILDLNCNPKLVAs 895
Cdd:cd03798  269 QVPAYYRacdVFVLPSRHEGFGLVLLEAMACGLPVVATDVGGIPEVVgDPETGLLVPPGDADALAAALRRALAEPYLRE- 347

                        250       260
                 ....*....|....*....|..
gi 407292567 896 MGNCAAKRAKELFSRDTFGKKL 917
Cdd:cd03798  348 LGEAARARVAERFSWVKAADRI 369
GT4_GT28_WabH-like cd03811
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most ...
 583-872 2.54e-16

family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.


Pssm-ID: 340839 [Multi-domain]  Cd Length: 351  Bit Score: 81.64  E-value: 2.54e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 583 GAERSLVDIAEAMQKANISITLFLPSCSNITYIEELKQFvrKIVFLPLPWANGREEPIQPVAQYLESDFLHCGYDCVYVN 662
Cdd:cd03811   13 GAERVLLNLANALDKRGYDVTLVLLRDEGDLDKQLNGDV--KLIRLLIRVLKLIKLGLLKAILKLKRILKRAKPDVVISF 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 663 TLTLIEPLSAAKKAGIPMVMHVRelveFDNDLADLLRESPQRtHARVIATSDYFIANSEETARWINE-----PERTTVIY 737
Cdd:cd03811   91 LGFATYIVAKLAAARSKVIAWIH----SSLSKLYYLKKKLLL-KLKLYKKADKIVCVSKGIKEDLIRlgpspPEKIEVIY 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 738 NCVD--------TSPSQNSmPSGALKICMLSSNVKKKGVEDFFEVAS-LCKEASNIQFTIYG--PITNEVIMAAKRFGDA 806
Cdd:cd03811  166 NPIDidriralaKEPILNE-PEDGPVILAVGRLDPQKGHDLLIEAFAkLRKKYPDVKLVILGdgPLREELEKLAKELGLA 244

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 407292567 807 N-ITIAGYVEKP----KEAMaehhiVLALSHFKESFGRTVAEAMSLGRVVVGYDWGAVNELVDKQS-GILVD 872
Cdd:cd03811  245 ErVIFLGFQSNPypylKKAD-----LFVLSSRYEGFPNVLLEAMALGTPVVSTDCPGPREILDDGEnGLLVP 311
GT2_RfbC_Mx_like cd04184
Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; The rfbC gene ...
 213-307 5.45e-16

Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; The rfbC gene encodes a predicted protein of 1,276 amino acids, which is required for O-antigen biosynthesis in Myxococcus xanthus. It is a subfamily of Glycosyltransferase Family GT2, which includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds.


Pssm-ID: 133027 [Multi-domain]  Cd Length: 202  Bit Score: 77.63  E-value: 5.45e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 213 KVSIIVPVFNA-EKVISTSINSLLNQSWKNIEIIAVDDASTDNSYTELKRLYGGID-RVRIIKNNKNKGAYATRNLGMTL 290
Cdd:cd04184    2 LISIVMPVYNTpEKYLREAIESVRAQTYPNWELCIADDASTDPEVKRVLKKYAAQDpRIKVVFREENGGISAATNSALEL 81

                         90
                 ....*....|....*..
gi 407292567 291 ASGNFLTVMDADDWAHP 307
Cdd:cd04184   82 ATGEFVALLDHDDELAP 98
GT_2_like_c cd04186
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 216-371 1.19e-15

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133029 [Multi-domain]  Cd Length: 166  Bit Score: 75.29  E-value: 1.19e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 216 IIVPVFNAEKVISTSINSLLNQSWKNIEIIAVDDASTDNSYTELKRLYggiDRVRIIKNNKNKGAYATRNLGMTLASGNF 295
Cdd:cd04186    1 IIIVNYNSLEYLKACLDSLLAQTYPDFEVIVVDNASTDGSVELLRELF---PEVRLIRNGENLGFGAGNNQGIREAKGDY 77

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 407292567 296 LTVMDADDWAHPqkiekqvipllfnrslkGTVSHWVRCTEDlefsRLRVGNswVHRNVS--SLLVRKDVVASLGGWDE 371
Cdd:cd04186   78 VLLLNPDTVVEP-----------------GALLELLDAAEQ----DPDVGI--VGPKVSgaFLLVRREVFEEVGGFDE 132
DPM_DPG-synthase_like cd04179
DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the ...
 216-368 2.00e-15

DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133022 [Multi-domain]  Cd Length: 185  Bit Score: 75.30  E-value: 2.00e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 216 IIVPVFNAEKVISTSINSLLN--QSWKNIEIIAVDDASTDNSYTELKRLYGGIDRVRIIKNNKNKG---AYATrnlGMTL 290
Cdd:cd04179    1 VVIPAYNEEENIPELVERLLAvlEEGYDYEIIVVDDGSTDGTAEIARELAARVPRVRVIRLSRNFGkgaAVRA---GFKA 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 291 ASGNFLTVMDADDwAHPqkIEkqVIPLLFNRSLKGTV-----SHWVRCTEDLEFSRLRVGNSWVHRnVSSLLVRKDVVAS 365
Cdd:cd04179   78 ARGDIVVTMDADL-QHP--PE--DIPKLLEKLLEGGAdvvigSRFVRGGGAGMPLLRRLGSRLFNF-LIRLLLGVRISDT 151


                 ...
gi 407292567 366 LGG 368
Cdd:cd04179  152 QSG 154
DPM1_like_bac cd04187
Bacterial DPM1_like enzymes are related to eukaryotic DPM1; A family of bacterial enzymes ...
 216-302 8.22e-15

Bacterial DPM1_like enzymes are related to eukaryotic DPM1; A family of bacterial enzymes related to eukaryotic DPM1; Although the mechanism of eukaryotic enzyme is well studied, the mechanism of the bacterial enzymes is not well understood. The eukaryotic DPM1 is the catalytic subunit of eukaryotic Dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. The enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133030 [Multi-domain]  Cd Length: 181  Bit Score: 73.28  E-value: 8.22e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 216 IIVPVFNAEKVIS---TSINSLLNQSWKNIEIIAVDDASTDNSYTELKRLYGGIDRVRIIKNNKNKG-AYATRNlGMTLA 291
Cdd:cd04187    1 IVVPVYNEEENLPelyERLKAVLESLGYDYEIIFVDDGSTDRTLEILRELAARDPRVKVIRLSRNFGqQAALLA-GLDHA 79

                         90
                 ....*....|.
gi 407292567 292 SGNFLTVMDAD 302
Cdd:cd04187   80 RGDAVITMDAD 90
Succinoglycan_BP_ExoA cd02525
ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA ...
 213-383 3.30e-14

ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA catalyzes the formation of a beta-1,3 linkage of the second sugar (glucose) of the succinoglycan with the galactose on the lipid carrie. Succinoglycan is an acidic exopolysaccharide that is important for invasion of the nodules. Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide units. These units are synthesized on membrane-bound isoprenoid lipid carriers, beginning with galactose followed by seven glucose molecules, and modified by the addition of acetate, succinate, and pyruvate. ExoA is a membrane protein with a transmembrance domain at c-terminus.


Pssm-ID: 133016 [Multi-domain]  Cd Length: 249  Bit Score: 73.42  E-value: 3.30e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 213 KVSIIVPVFNAEKVISTSINSLLNQSW--KNIEIIAVDDASTDNSYTELKRLYGGIDRVRIIKNNKnKGAYATRNLGMTL 290
Cdd:cd02525    1 FVSIIIPVRNEEKYIEELLESLLNQSYpkDLIEIIVVDGGSTDGTREIVQEYAAKDPRIRLIDNPK-RIQSAGLNIGIRN 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 291 ASGNFLTVMDA-----DDW-AHPQKIEKQ-------VIPLLFNRSLKGTVSHWVrctedlEFSRLRVGNSwVHRNVS--- 354
Cdd:cd02525   80 SRGDIIIRVDAhavypKDYiLELVEALKRtgadnvgGPMETIGESKFQKAIAVA------QSSPLGSGGS-AYRGGAvki 152

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 407292567 355 -------SLLVRKDVVASLGGWDEVKV-NADTEFYER 383
Cdd:cd02525  153 gyvdtvhHGAYRREVFEKVGGFDESLVrNEDAELNYR 189
Glyco_transf_4 pfam13439
Glycosyltransferase Family 4;
583-743 4.20e-13

Glycosyltransferase Family 4;


Pssm-ID: 463877 [Multi-domain]  Cd Length: 169  Bit Score: 68.33  E-value: 4.20e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567  583 GAERSLVDIAEAMQKANISITLFLPSCSNITYIEELKQFVRKIVFLPLPWANGReepIQPVAQYLESDFLHCGYDCVYVN 662
Cdd:pfam13439   2 GVERYVLELARALARRGHEVTVVTPGGPGPLAEEVVRVVRVPRVPLPLPPRLLR---SLAFLRRLRRLLRRERPDVVHAH 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567  663 TLTLIEP--LSAAKKAGIPMVMHV---RELVEFDNDLADLLRESPQRTHARVIATSDYFIANSEETARWINE-----PER 732
Cdd:pfam13439  79 SPFPLGLaaLAARLRLGIPLVVTYhglFPDYKRLGARLSPLRRLLRRLERRLLRRADRVIAVSEAVADELRRlygvpPEK 158

                         170
                  ....*....|.
gi 407292567  733 TTVIYNCVDTS 743
Cdd:pfam13439 159 IRVIPNGVDLE 169
GT_2_like_d cd04196
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 215-314 4.23e-13

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133039 [Multi-domain]  Cd Length: 214  Bit Score: 69.20  E-value: 4.23e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 215 SIIVPVFNAEKVISTSINSLLNQSWKNIEIIAVDDASTDNSYTELKRlYGGID--RVRIIKNNKNKGAYATRNLGMTLAS 292
Cdd:cd04196    1 AVLMATYNGEKYLREQLDSILAQTYKNDELIISDDGSTDGTVEIIKE-YIDKDpfIIILIRNGKNLGVARNFESLLQAAD 79

                         90       100
                 ....*....|....*....|....*
gi 407292567 293 GNFltVM--DADD-WaHPQKIEKQV 314
Cdd:cd04196   80 GDY--VFfcDQDDiW-LPDKLERLL 101
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 755-903 7.36e-13

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 67.30  E-value: 7.36e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567  755 KICMLSSNVKKKGVEDFFE-VASLCKEASNIQFTIYGPITNE---VIMAAKRFGDANITIAGYV--EKPKEAMAEHHIVL 828
Cdd:pfam00534   4 IILFVGRLEPEKGLDLLIKaFALLKEKNPNLKLVIAGDGEEEkrlKKLAEKLGLGDNVIFLGFVsdEDLPELLKIADVFV 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 407292567  829 ALSHfKESFGRTVAEAMSLGRVVVGYDWGAVNELV-DKQSGILVDYKSTEKIVDAILDLNCNPKLVASMGNCAAKR 903
Cdd:pfam00534  84 LPSR-YEGFGIVLLEAMACGLPVIASDVGGPPEVVkDGETGFLVKPNNAEALAEAIDKLLEDEELRERLGENARKR 158
PRK10018 PRK10018
colanic acid biosynthesis glycosyltransferase WcaA;
214-310 8.23e-13

colanic acid biosynthesis glycosyltransferase WcaA;


Pssm-ID: 182197 [Multi-domain]  Cd Length: 279  Bit Score: 70.02  E-value: 8.23e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 214 VSIIVPVFNAEKVISTSINSLLNQSWKNIEIIAVDDASTdnSYTELKRLYGGID--RVRIIKNNKNKGAYATRNLGMTLA 291
Cdd:PRK10018   7 ISIYMPTWNRQQLAIRAIKSVLRQDYSNWEMIIVDDCST--SWEQLQQYVTALNdpRITYIHNDINSGACAVRNQAIMLA 84

                         90
                 ....*....|....*....
gi 407292567 292 SGNFLTVMDADDWAHPQKI 310
Cdd:PRK10018  85 QGEYITGIDDDDEWTPNRL 103
GT4_AmsD-like cd03820
amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most ...
 583-912 1.92e-12

amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be responsible for the formation of galactose alpha-1,6 linkages in amylovoran.


Pssm-ID: 340847 [Multi-domain]  Cd Length: 351  Bit Score: 69.57  E-value: 1.92e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 583 GAERSLVDIAEAMQKANISITLFLPSCSNITYIEELKQFVrKIVFLPLPwangREEPIQPVAQYLESDFLH------CGY 656
Cdd:cd03820   14 GAERVAINLANHLAKKGYDVTIISLDSAEKPPFYELDDNI-KIKNLGDR----KYSHFKLLLKYFKKVRRLrkylknNKP 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 657 DcVYVNTLTLIEPLSAAKKAGIPMVmhVRELVEFDNDLADLLRESPQRTHARviaTSDYFIANSEETARWINEPERT--T 734
Cdd:cd03820   89 D-VVISFRTSLLTFLALIGLKSKLI--VWEHNNYEAYNKGLRRLLLRRLLYK---RADKIVVLTEADKLKKYKQPNSnvV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 735 VIYNCVDTSPSQNSMPSGALKICMLSSNVKKKGVEDFFEV-ASLCKEASNIQFTIYG--PITNEVIMAAKRFGDAN-ITI 810
Cdd:cd03820  163 VIPNPLSFPSEEPSTNLKSKRILAVGRLTYQKGFDLLIEAwALIAKKHPDWKLRIYGdgPEREELEKLIDKLGLEDrVKL 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 811 AGYVEKPKEAMAEHHI-VLAlSHFkESFGRTVAEAMSLGRVVVGYD--WGaVNELV-DKQSGILVDYKSTEKIVDAILDL 886
Cdd:cd03820  243 LGPTKNIAEEYANSSIfVLS-SRY-EGFPMVLLEAMAYGLPIISFDcpTG-PSEIIeDGENGLLVPNGDVDALAEALLRL 319

                        330       340
                 ....*....|....*....|....*.
gi 407292567 887 NCNPKLVASMGNCAAKRAKElFSRDT 912
Cdd:cd03820  320 MEDEELRKKMGKNARKNAER-FSIEK 344
DPG_synthase cd04188
DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate ...
 216-302 1.28e-11

DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate.


Pssm-ID: 133031 [Multi-domain]  Cd Length: 211  Bit Score: 64.90  E-value: 1.28e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 216 IIVPVFNAEKVISTSINS----LLNQSWKNIEIIAVDDASTDNSY---TELKRLYGgiDRVRIIKNNKNKG-AYATRnLG 287
Cdd:cd04188    1 VVIPAYNEEKRLPPTLEEaveyLEERPSFSYEIIVVDDGSKDGTAevaRKLARKNP--ALIRVLTLPKNRGkGGAVR-AG 77

                         90
                 ....*....|....*
gi 407292567 288 MTLASGNFLTVMDAD 302
Cdd:cd04188   78 MLAARGDYILFADAD 92
beta3GnTL1_like cd06913
Beta 1, 3-N-acetylglucosaminyltransferase is essential for the formation of ...
 216-313 3.72e-10

Beta 1, 3-N-acetylglucosaminyltransferase is essential for the formation of poly-N-acetyllactosamine ; This family includes human Beta3GnTL1 and related eukaryotic proteins. Human Beta3GnTL1 is a putative beta-1,3-N-acetylglucosaminyltransferase. Beta3GnTL1 is expressed at various levels in most of tissues examined. Beta 1, 3-N-acetylglucosaminyltransferase has been found to be essential for the formation of poly-N-acetyllactosamine. Poly-N-acetyllactosamine is a unique carbohydrate composed of N-acetyllactosamine repeats. It is often an important part of cell-type-specific oligosaccharide structures and some functional oligosaccharides. It has been shown that the structure and biosynthesis of poly-N-acetyllactosamine display a dramatic change during development and oncogenesis. Several members of beta-1, 3-N-acetylglucosaminyltransferase have been identified.


Pssm-ID: 133063 [Multi-domain]  Cd Length: 219  Bit Score: 60.93  E-value: 3.72e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 216 IIVPVFNAEKVISTSINSLLNQSWKN-IEIIAVDDASTDNSYTEL----KRLYGGIDRVRIIKNNKN--KGAYATRNLGM 288
Cdd:cd06913    1 IILPVHNGEQWLDECLESVLQQDFEGtLELSVFNDASTDKSAEIIekwrKKLEDSGVIVLVGSHNSPspKGVGYAKNQAI 80

                         90       100
                 ....*....|....*....|....*
gi 407292567 289 TLASGNFLTVMDADDWAHPQKIEKQ 313
Cdd:cd06913   81 AQSSGRYLCFLDSDDVMMPQRIRLQ 105
CESA_like_1 cd06439
CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of ...
 213-302 4.33e-10

CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of cellulose synthase (CESA) superfamily. CESA superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members of the superfamily include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins.


Pssm-ID: 133061 [Multi-domain]  Cd Length: 251  Bit Score: 61.06  E-value: 4.33e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 213 KVSIIVPVFNAEKVISTSINSLLNQSWKN--IEIIAVDDASTDNSYtELKRLYGGiDRVRIIKNNKNKGAYATRNLGMTL 290
Cdd:cd06439   30 TVTIIIPAYNEEAVIEAKLENLLALDYPRdrLEIIVVSDGSTDGTA-EIAREYAD-KGVKLLRFPERRGKAAALNRALAL 107

                         90
                 ....*....|..
gi 407292567 291 ASGNFLTVMDAD 302
Cdd:cd06439  108 ATGEIVVFTDAN 119
Glycosyltransferase_GTB-type cd01635
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
 763-871 4.36e-10

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340816 [Multi-domain]  Cd Length: 235  Bit Score: 60.88  E-value: 4.36e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 763 VKKKGVEDFFEVASLCKEA-SNIQFTIYGPITN----EVIMAAKRFGDANITIAGYVEKPKEAMAEHHI-VLALSHFKES 836
Cdd:cd01635  120 VPEKGIDLLLEALALLKARlPDLVLVLVGGGGEreeeEALAAALGLLERVVIIGGLVDDEVLELLLAAAdVFVLPSRSEG 199

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 407292567 837 FGRTVAEAMSLGRVVVGYDWGAVNELV-DKQSGILV 871
Cdd:cd01635  200 FGLVLLEAMAAGKPVIATDVGGIPEFVvDGENGLLV 235
PLN02726 PLN02726
dolichyl-phosphate beta-D-mannosyltransferase
 206-310 5.63e-10

dolichyl-phosphate beta-D-mannosyltransferase


Pssm-ID: 215385 [Multi-domain]  Cd Length: 243  Bit Score: 60.87  E-value: 5.63e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 206 KALVSKSKVSIIVPVFNAEKVISTsINSLLN---QSWKNIEIIAVDDASTDNSYT---ELKRLYGGiDRVRIIKNNKNKG 279
Cdd:PLN02726   3 APGEGAMKYSIIVPTYNERLNIAL-IVYLIFkalQDVKDFEIIVVDDGSPDGTQDvvkQLQKVYGE-DRILLRPRPGKLG 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 407292567 280 ---AYATrnlGMTLASGNFLTVMDADDWAHPQKI 310
Cdd:PLN02726  81 lgtAYIH---GLKHASGDFVVIMDADLSHHPKYL 111
pp-GalNAc-T cd02510
pp-GalNAc-T initiates the formation of mucin-type O-linked glycans; UDP-GalNAc: polypeptide ...
 215-301 9.02e-10

pp-GalNAc-T initiates the formation of mucin-type O-linked glycans; UDP-GalNAc: polypeptide alpha-N-acetylgalactosaminyltransferases (pp-GalNAc-T) initiate the formation of mucin-type, O-linked glycans by catalyzing the transfer of alpha-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to hydroxyl groups of Ser or Thr residues of core proteins to form the Tn antigen (GalNAc-a-1-O-Ser/Thr). These enzymes are type II membrane proteins with a GT-A type catalytic domain and a lectin domain located on the lumen side of the Golgi apparatus. In human, there are 15 isozymes of pp-GalNAc-Ts, representing the largest of all glycosyltransferase families. Each isozyme has unique but partially redundant substrate specificity for glycosylation sites on acceptor proteins.


Pssm-ID: 133004 [Multi-domain]  Cd Length: 299  Bit Score: 61.07  E-value: 9.02e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 215 SIIVPVFN-AEKVISTSINSLLNQSWKN--IEIIAVDDAST-DNSYTELKRLY-GGIDRVRIIKNNKNKGAYATRNLGMT 289
Cdd:cd02510    1 SVIIIFHNeALSTLLRTVHSVINRTPPEllKEIILVDDFSDkPELKLLLEEYYkKYLPKVKVLRLKKREGLIRARIAGAR 80

                         90
                 ....*....|..
gi 407292567 290 LASGNFLTVMDA 301
Cdd:cd02510   81 AATGDVLVFLDS 92
DPM1_like cd06442
DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to ...
 216-359 2.13e-09

DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to eukaryotic DPM1, including enzymes from bacteria and archaea; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133062 [Multi-domain]  Cd Length: 224  Bit Score: 58.70  E-value: 2.13e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 216 IIVPVFNaEK----VISTSINSLLNQswKNIEIIAVDDASTDNSYTELKRLYGGIDRVRIIKNNKNKG---AYATrnlGM 288
Cdd:cd06442    1 IIIPTYN-ERenipELIERLDAALKG--IDYEIIVVDDNSPDGTAEIVRELAKEYPRVRLIVRPGKRGlgsAYIE---GF 74

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 407292567 289 TLASGNFLTVMDAdDWAHPQKiekqVIPLLFNRSLKGTV-----SHWVRCTEDLEFSRLRVGNSWVHRNVSSLLVR 359
Cdd:cd06442   75 KAARGDVIVVMDA-DLSHPPE----YIPELLEAQLEGGAdlvigSRYVEGGGVEGWGLKRKLISRGANLLARLLLG 145
GT4_MtfB-like cd03809
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to ...
 708-919 2.84e-09

glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. MtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the previously synthesized polysaccharide.


Pssm-ID: 340838 [Multi-domain]  Cd Length: 362  Bit Score: 60.07  E-value: 2.84e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 708 RVIATSDYFIANSEETA----RWINEP-ERTTVIYNCVDTSPSQNSMPSGALK--------ICMLSSNVKKKGVEDFFEV 774
Cdd:cd03809  134 ISLRRADAIITVSEATRddiiKFYGVPpEKIVVIPLGVDPSFFPPESAAVLIAkyllpepyFLYVGTLEPRKNHERLLKA 213

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 775 ASLCKEAS-NIQFTIYGPITNEVI----MAAKRFGDANITIAGYVEKPK--EAMAEHHIVLALSHFkESFGRTVAEAMSL 847
Cdd:cd03809  214 FALLKKQGgDLKLVIVGGKGWEDEelldLVKKLGLGGRVRFLGYVSDEDlpALYRGARAFVFPSLY-EGFGLPVLEAMAC 292

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 407292567 848 GRVVVGYDWGAVNElVDKQSGILVDYKSTEKIVDAILDLNCNPKLVASMGNCAAKRAKeLFSRDTFGKKLVN 919
Cdd:cd03809  293 GTPVIASNISVLPE-VAGDAALYFDPLDPESIADAILRLLEDPSLREELIRKGLERAK-KFSWEKTAEKTLE 362
GT4_AviGT4-like cd03802
UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is ...
 583-916 5.27e-09

UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant that accumulated a novel avilamycin derivative lacking the terminal eurekanate residue.


Pssm-ID: 340832 [Multi-domain]  Cd Length: 333  Bit Score: 58.84  E-value: 5.27e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 583 GAERSLVDIAEAMQKANISITLFLP-----SCSNITYIEELkqfvrkivflPLPWANGRE----EPIQPVAQYLESDflh 653
Cdd:cd03802   19 GTELVVSALTEGLVRRGHEVTLFAPgdshtSAPLVAVIPRA----------LRLDPIPQEsklaELLEALEVQLRAS--- 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 654 cGYDCVYVNTLTLIEPLSAAKKAGIPMVMHVRELVEfdnDLADLLRESPQRtharviatsdyFIANSEETARWINEPERT 733
Cdd:cd03802   86 -DFDVIHNHSYDWLPPFAPLIGTPFVTTLHGPSIPP---SLAIYAAEPPVN-----------YVSISDAQRAATPPIDYL 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 734 TVIYNCVDTS--PSQNSMPSGAL---KICmlssnvKKKGVEDFFEVASlckeASNIQFTIYGPITNEviMAAKR----FG 804
Cdd:cd03802  151 TVVHNGLDPAdyRFQPDPEDYLAflgRIA------PEKGLEDAIRVAR----RAGLPLKIAGKVRDE--DYFYYlqepLP 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 805 DANITIAGYV--EKPKEAMAEHHIVLALSHFKESFGRTVAEAMSLGRVVVGYDWGAVNELVDKQ-SGILVDykSTEKIVD 881
Cdd:cd03802  219 GPRIEFIGEVghDEKQELLGGARALLFPINWDEPFGLVMIEAMACGTPVIAYRRGGLPEVIQHGeTGFLVD--SVEEMAE 296

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 407292567 882 AILDLncnPKLvaSMGNCAAkRAKELFSRDTFGKK 916
Cdd:cd03802  297 AIANI---DRI--DRAACRR-YAEDRFSAARMADR 325
GT4_AmsK-like cd03799
Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases ...
 693-908 5.34e-09

Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases found specifically in certain bacteria. AmsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor.


Pssm-ID: 340829 [Multi-domain]  Cd Length: 350  Bit Score: 59.00  E-value: 5.34e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 693 DLADLLRESPQRTHARVIATSDYFIANSEetaRWINE-------PERTTVIYNCVDTSPSQNSM----PSGALKICMLSS 761
Cdd:cd03799  106 DISMYVILEGNKVYPQLFAQGDLFLPNCE---LFKHRlialgcdEKKIIVHRSGIDCNKFRFKPrylpLDGKIRILTVGR 182

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 762 NVKKKGVEDFFE-VASLCKEASNIQFTI--YGPITNEV--IMAAKRFGDaNITIAGYVEKP--KEAMAEHHIVLALSHF- 833
Cdd:cd03799  183 LTEKKGLEYAIEaVAKLAQKYPNIEYQIigDGDLKEQLqqLIQELNIGD-CVKLLGWKPQEeiIEILDEADIFIAPSVTa 261

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 834 ----KESFGRTVAEAMSLGRVVVGYDWGAVNELV-DKQSGILVDYKSTEKIVDAILDLNCNPKLVASMGNCAAKRAKELF 908
Cdd:cd03799  262 adgdQDGPPNTLKEAMAMGLPVISTEHGGIPELVeDGVSGFLVPERDAEAIAEKLTYLIEHPAIWPEMGKAGRARVEEEY 341
Glyco_tranf_2_3 pfam13641
Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include ...
 214-370 7.80e-09

Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 433372 [Multi-domain]  Cd Length: 230  Bit Score: 57.00  E-value: 7.80e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567  214 VSIIVPVFNAEKVISTSINSLLNQSWKNIEIIAV---DDASTDNSYTELKRLYGGIdRVRIIKNNKNKGAYATR---NLG 287
Cdd:pfam13641   4 VSVVVPAFNEDSVLGRVLEAILAQPYPPVEVVVVvnpSDAETLDVAEEIAARFPDV-RLRVIRNARLLGPTGKSrglNHG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567  288 MTLASGNFLTVMDADDWAHPQKIEKQVIPLLFNR-SLKGTV------SHWVRCTEDLEFSRlRVGNSWVHRNVSSL---- 356
Cdd:pfam13641  83 FRAVKSDLVVLHDDDSVLHPGTLKKYVQYFDSPKvGAVGTPvfslnrSTMLSALGALEFAL-RHLRMMSLRLALGVlpls 161

                         170
                  ....*....|....*...
gi 407292567  357 ----LVRKDVVASLGGWD 370
Cdd:pfam13641 162 gagsAIRREVLKELGLFD 179
GT_2_like_a cd02522
GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; ...
 214-393 8.53e-09

GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Glycosyltransferase family 2 (GT-2) subfamily of unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133013 [Multi-domain]  Cd Length: 221  Bit Score: 56.81  E-value: 8.53e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 214 VSIIVPVFNAEKVISTSINSLLNQSWKNIEIIAVDDASTDNSyTELKRLYGgidrVRIIKNNKNKGayATRNLGMTLASG 293
Cdd:cd02522    1 LSIIIPTLNEAENLPRLLASLRRLNPLPLEIIVVDGGSTDGT-VAIARSAG----VVVISSPKGRA--RQMNAGAAAARG 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 294 NFLTVMDAD-----DWAHpQKIEKQVIP--------LLFNRSlkgtvSHWVRCTEDLEFSRLRvgnswvHRNV----SSL 356
Cdd:cd02522   74 DWLLFLHADtrlppDWDA-AIIETLRADgavagafrLRFDDP-----GPRLRLLELGANLRSR------LFGLpygdQGL 141

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 407292567 357 LVRKDVVASLGGWDEVKVNADTEFYERcLAKFGKAAI 393
Cdd:cd02522  142 FIRRELFEELGGFPELPLMEDVELVRR-LRRRGRPAL 177
GT4_BshA-like cd04962
N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most ...
 675-909 1.04e-07

N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340859 [Multi-domain]  Cd Length: 370  Bit Score: 55.05  E-value: 1.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 675 KAGIPMV--MHVRE--LVEFDNDLADLLRESPQRTHaRVIATSDYFianSEETARWINEPERTTVIYNCVDTS--PSQNS 748
Cdd:cd04962  108 GEKIPIVttLHGTDitLVGYDPSLQPAVRFSINKSD-RVTAVSSSL---RQETYELFDVDKDIEVIHNFIDEDvfKRKPA 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 749 MP----SGAL---KICMLSSNVKK-KGVEDFFEVASLCKEASNIQFTIYG--PITNEVIMAAKRFGDAN-ITIAGYVEKP 817
Cdd:cd04962  184 GAlkrrLLAPpdeKVVIHVSNFRPvKRIDDVVRVFARVRRKIPAKLLLVGdgPERVPAEELARELGVEDrVLFLGKQDDV 263

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 818 KEAMAEHHIVLALSHfKESFGRTVAEAMSLGRVVVGYDWGAVNELVDK-QSGILVDYKSTEKIVDAILDLNCNPKLVASM 896
Cdd:cd04962  264 EELLSIADLFLLPSE-KESFGLAALEAMACGVPVVSSNAGGIPEVVKHgETGFLSDVGDVDAMAKSALSILEDDELYNRM 342

                        250
                 ....*....|...
gi 407292567 897 GNCAAKRAKELFS 909
Cdd:cd04962  343 GRAARKRAAERFD 355
thiol_BshA TIGR03999
N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Members of this protein family are BshA, ...
 643-920 1.23e-07

N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Members of this protein family are BshA, a glycosyltransferase required for bacillithiol biosynthesis. This enzyme combines UDP-GlcNAc and L-malate to form N-acetyl-alpha-D-glucosaminyl L-malate synthase. Bacillithiol is a low-molecular-weight thiol, an analog of glutathione and mycothiol, and is found largely in the Firmicutes. [Biosynthesis of cofactors, prosthetic groups, and carriers, Glutathione and analogs]


Pssm-ID: 274914 [Multi-domain]  Cd Length: 374  Bit Score: 54.92  E-value: 1.23e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567  643 VAQYLESDFLHCGYDCVYVNTLTLIEPLSAAKKAGIPMV--MHVRE--LVEFDNDLADLLRESPQRTHArVIATSDYFIa 718
Cdd:TIGR03999  79 VAKEEKLDLLHVHYAIPHAIAAYLARQMLGKEGIDIPIVttLHGTDitLVGADPSFKPAVRFSIEKSDG-VTAVSESLK- 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567  719 nsEETARWINEPERTTVIYNCVDTS---PSQNSMPSGAL------KICMLSSNVKK-KGVEDFFEV-ASLCKEASNIQFT 787
Cdd:TIGR03999 157 --EETYELFDIDKPIEVIPNFVDTDryrRKNDPALKRKLgapedeKVLIHISNFRPvKRVEDVIEVfARVQQEVPAKLLL 234

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567  788 I-YGPITNEVIMAAKRFGDAN-ITIAGYVEKPKEAMAEHHIVLALSHfKESFGRTVAEAMSLGRVVVGYDWGAVNELV-D 864
Cdd:TIGR03999 235 VgDGPERSPAEQLVRELGLTDrVLFLGKQDDVAELLSISDLFLLPSE-KESFGLAALEAMACGVPVIASNAGGIPEVVeH 313

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 407292567  865 KQSGILVDYKSTEKIVDAILDLNCNPKLVASMGNCAAKRAKELFSRdtfgKKLVNQ 920
Cdd:TIGR03999 314 GVTGFLCDVGDVETMAEYAISLLEDEELLQRFSAAARERAKERFDS----EKIVPQ 365
GT4_GtfA-like cd04949
accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most ...
 774-910 6.22e-07

accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340855 [Multi-domain]  Cd Length: 328  Bit Score: 52.30  E-value: 6.22e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 774 VASLCKEASNIQFTIYG-----PITNEVImAAKRFGDaNITIAGYVEKPKEAMAEHHIVLALSHFkESFGRTVAEAMSLG 848
Cdd:cd04949  182 VAKAVKKVPEITLDIYGygeerEKLKKLI-EELHLED-NVFLKGYHSNLDQEYQDAYLSLLTSQM-EGFGLTLMEAIGHG 258

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 407292567 849 RVVVGYD--WGAvNELV-DKQSGILVDYKSTEKIVDAILDLNCNPKLVASMGNCAAKRAKElFSR 910
Cdd:cd04949  259 LPVVSYDvkYGP-SELIeDGENGYLIEKNNIDALADKIIELLNDPEKLQQFSEESYKIAEK-YST 321
GT4_WcaC-like cd03825
putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family ...
 694-919 1.51e-06

putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Escherichia coli WcaC has been predicted to function in colanic acid biosynthesis. WcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis.


Pssm-ID: 340851 [Multi-domain]  Cd Length: 364  Bit Score: 51.56  E-value: 1.51e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 694 LADLLRESPQRTHARVIatsdyfianseetarwineperttVIYNCVDT----------SPSQNSMPSGALKICMLSSNV 763
Cdd:cd03825  148 LADMVRRSPLLKGLPVV------------------------VIPNGIDTeifapvdkakARKRLGIPQDKKVILFGAESV 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 764 --KKKGVEDFFEVASLCKEASNIQFTIYGPITNEvimaaKRFGDANITIAGYVEKpkeamaEHHIVLALS------HF-- 833
Cdd:cd03825  204 tkPRKGFDELIEALKLLATKDDLLLVVFGKNDPQ-----IVILPFDIISLGYIDD------DEQLVDIYSaadlfvHPsl 272

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 834 KESFGRTVAEAMSLGRVVVGYDWGAVNELV-DKQSGILVDYKSTEKIVDAILDLNCNPKLVASMGNCAAKRAKELFSRDT 912
Cdd:cd03825  273 ADNLPNTLLEAMACGTPVVAFDTGGSPEIVqHGVTGYLVPPGDVQALAEAIEWLLANPKERESLGERARALAENHFDQRV 352


                 ....*..
gi 407292567 913 FGKKLVN 919
Cdd:cd03825  353 QAQRYLE 359
GT4_WfcD-like cd03795
Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most ...
 766-911 1.56e-06

Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP-linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340826 [Multi-domain]  Cd Length: 355  Bit Score: 51.51  E-value: 1.56e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 766 KGVEDFFEVASLckeasnIQFTIY----GPITNEVIMAAKRFGDANITIAGYVEKpKEAMAEHHI--VLAL-SHFK-ESF 837
Cdd:cd03795  204 KGLDYLIEAAQY------LNYPIViggeGPLKPDLEAQIELNLLDNVKFLGRVDD-EEKVIYLHLcdVFVFpSVLRsEAF 276

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 407292567 838 GRTVAEAMSLGRVVVGYDWG-AVNELV-DKQSGILVDYKSTEKIVDAILDLNCNPKLVASMGNCAAKRAKELFSRD 911
Cdd:cd03795  277 GIVLLEAMMCGKPVISTNIGtGVPYVNnNGETGLVVPPKDPDALAEAIDKLLSDEELRESYGENAKKRFEELFTAE 352
GT4_WbaZ-like cd03804
mannosyltransferase WbaZ and similar proteins; This family is most closely related to the GT4 ...
 698-917 1.57e-06

mannosyltransferase WbaZ and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbaZ in Salmonella enterica has been shown to possess mannosyltransferase activity.


Pssm-ID: 340833 [Multi-domain]  Cd Length: 356  Bit Score: 51.52  E-value: 1.57e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 698 LRESPQRTHARViatsDYFIANSEETARWINEPER--TTVIYNCVDT---SPSQNSmpsgalkicmlssnvkkkgvEDFF 772
Cdd:cd03804  147 LRLWDVRTAQRV----DLFIANSQFVARRIKKFYGreSTVIYPPVDTdafAPAADK--------------------EDYY 202

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 773 EVAS---------LCKEA---SNIQFTIYGpiTNEVIMAAKRFGDANITIAGYVEKP--KEAMAEHHIVLALShfKESFG 838
Cdd:cd03804  203 LTASrlvpykridLAVEAfneLPKRLVVIG--DGPDLDRLRAMASPNVEFLGYQPDEvlKELLSKARAFVFAA--EEDFG 278

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 839 RTVAEAMSLGRVVVGYDWGAVNELV-DKQSGILVDYKSTEKIVDAILDLNCNPKLVASMgncAAKRAKELFSRDTFGKKL 917
Cdd:cd03804  279 IVPVEAQACGTPVIAFGKGGALETVrPGPTGILFGEQTVESLKAAVEEFEQNFDRFKPQ---AIRANAERFSRARFRQEI 355
Glyco_tranf_2_2 pfam10111
Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include ...
 215-449 2.00e-06

Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 313356 [Multi-domain]  Cd Length: 276  Bit Score: 50.35  E-value: 2.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567  215 SIIVPVFNAEK--VISTSINSLLNQSWKNIEIIAVDDASTDNSYTELKRLYGGidRVRIIKNNKNKGAY---ATRNLGMT 289
Cdd:pfam10111   1 SVVIPVYNGEKthWIQERILNQTFQYDPEFELIIINDGSTDKTLEEVSSIKDH--NLQVYYPNAPDTTYslaASRNRGTS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567  290 LASGNFLTVMDADDWAHPQKIEKQV-------IPLLFNRSLKGTVSHWVR-------------CTEDLEFSRLRVGNSWV 349
Cdd:pfam10111  79 HAIGEYISFIDGDCLWSPDKFEKQLkiatslaLQENIQAAVVLPVTDLNDessnflrrggdltASGDVLRDLLVFYSPLA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567  350 H---RNVSSLLVRKDVVASLGGWDEVKVNADTEFYErCLAKFGKAAIKEVMPDVPLSFgRTHASSLTQnaETHLVTQYGG 426
Cdd:pfam10111 159 IffaPNSSNALINRQAFIEVGGFDESFRGHGAEDFD-IFLRLAARYPFVAVMPPQLLY-RLSAKSMSP--YSGFRRFLGD 234

                         250       260
                  ....*....|....*....|....*..
gi 407292567  427 VRKQYMDCA----RAWHKNSPGLQLLR 449
Cdd:pfam10111 235 LARQAAACGkvlkHAYHDAPPSLQYLK 261
PTZ00260 PTZ00260
dolichyl-phosphate beta-glucosyltransferase; Provisional
 215-302 2.21e-06

dolichyl-phosphate beta-glucosyltransferase; Provisional


Pssm-ID: 240336 [Multi-domain]  Cd Length: 333  Bit Score: 50.92  E-value: 2.21e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 215 SIIVPVFNAE----KVISTSINSLLNQSWKNI----EIIAVDDASTDNSYTELKRLY----GGIDRVRIIKNNKNKGAYA 282
Cdd:PTZ00260  73 SIVIPAYNEEdrlpKMLKETIKYLESRSRKDPkfkyEIIIVNDGSKDKTLKVAKDFWrqniNPNIDIRLLSLLRNKGKGG 152

                         90       100
                 ....*....|....*....|
gi 407292567 283 TRNLGMTLASGNFLTVMDAD 302
Cdd:PTZ00260 153 AVRIGMLASRGKYILMVDAD 172
GT4-like cd03813
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 729-913 2.53e-06

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340841 [Multi-domain]  Cd Length: 474  Bit Score: 51.18  E-value: 2.53e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 729 EPERTTVIYNCVDTSPSQNSMPSGALKICMLSSNVKK----KGVEDFFEVASLCKEA-SNIQFTIYGPIT------NEVI 797
Cdd:cd03813  265 DPDKTRVIPNGIDIQRFAPAREERPEKEPPVVGLVGRvvpiKDVKTFIRAFKLVRRAmPDAEGWLIGPEDedpeyaQECK 344

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 798 MAAKRFGDANITIAGYVEKPKEAMAEHHIVlALSHFKESFGRTVAEAMSLGRVVVGYDWGAVNELVD------KQSGILV 871
Cdd:cd03813  345 RLVASLGLENKVKFLGFQNIKEYYPKLGLL-VLTSISEGQPLVILEAMASGVPVVATDVGSCRELIYgaddalGQAGLVV 423

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 407292567 872 DYKSTEKIVDAILDLNCNPKLVASMGNCAAKRAKELFSRDTF 913
Cdd:cd03813  424 PPADPEALAEALIKLLRDPELRQAFGEAGRKRVEKYYTLEGM 465
Beta4Glucosyltransferase cd02511
UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of ...
 213-312 2.59e-06

UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core.


Pssm-ID: 133005 [Multi-domain]  Cd Length: 229  Bit Score: 49.59  E-value: 2.59e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 213 KVSIIVPVFNAEKVISTSINSLLNQSwknIEIIAVDDASTDNSYtELKRLYGgidrVRIIKnNKNKGAYATRNLGMTLAS 292
Cdd:cd02511    1 TLSVVIITKNEERNIERCLESVKWAV---DEIIVVDSGSTDRTV-EIAKEYG----AKVYQ-RWWDGFGAQRNFALELAT 71

                         90       100
                 ....*....|....*....|
gi 407292567 293 GNFLTVMDADDWAHPQKIEK 312
Cdd:cd02511   72 NDWVLSLDADERLTPELADE 91
GT4_sucrose_synthase cd03800
sucrose-phosphate synthase and similar proteins; This family is most closely related to the ...
 672-909 3.10e-06

sucrose-phosphate synthase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose 6-phosphate and uridine 5'-diphosphate-glucose, a key regulatory step of sucrose metabolism. The activity of this enzyme is regulated by phosphorylation and moderated by the concentration of various metabolites and light.


Pssm-ID: 340830 [Multi-domain]  Cd Length: 398  Bit Score: 50.70  E-value: 3.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 672 AAKKAGIPMV--MHVRELVEFDNDLADLLRESPQRTHA--RVIATSDYFIANS-----EETARWINEPERTTVIYNCVD- 741
Cdd:cd03800  119 LARRLGVPLVhtFHSLGRVKYRHLGAQDTYHPSLRITAeeQILEAADRVIASTpqeadELISLYGADPSRINVVPPGVDl 198

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 742 -----TSPSQNSM-----PSGALKICMLSSNVKKKGVEDFFE-VASLCKEASNIQFTIY-GPI-------TNEVIMAAKR 802
Cdd:cd03800  199 erffpVDRAEARRarlllPPDKPVVLALGRLDPRKGIDTLVRaFAQLPELRELANLVLVgGPSddplsmdREELAELAEE 278

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 803 FGDAN-ITIAGYVekPKEAMAEHHI---VLALSHFKESFGRTVAEAMSLGR-VVVGYDWGAVNELVDKQSGILVDYKSTE 877
Cdd:cd03800  279 LGLIDrVRFPGRV--SRDDLPELYRaadVFVVPSLYEPFGLTAIEAMACGTpVVATAVGGLQDIVRDGRTGLLVDPHDPE 356

                        250       260       270
                 ....*....|....*....|....*....|..
gi 407292567 878 KIVDAILDLNCNPKLVASMGNCAAKRAKELFS 909
Cdd:cd03800  357 ALAAALRRLLDDPALWQRLSRAGLERARAHYT 388
GT4-like cd03814
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 835-906 4.33e-06

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases and includes a sequence annotated as alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol monomannoside transferase from Bacillus halodurans. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340842 [Multi-domain]  Cd Length: 365  Bit Score: 49.99  E-value: 4.33e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 407292567 835 ESFGRTVAEAMSLGRVVVGYDWGAVNELV-DKQSGILVDYKSTEKIVDAILDLNCNPKLVASMGNCAAKRAKE 906
Cdd:cd03814  278 ETFGLVVLEAMASGLPVVAADAGGPRDIVrPGGTGALVEPGDAAAFAAALRALLEDPELRRRMAARARAEAER 350
GT4_Bme6-like cd03821
Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 ...
 672-919 6.25e-06

Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide.


Pssm-ID: 340848 [Multi-domain]  Cd Length: 377  Bit Score: 49.67  E-value: 6.25e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 672 AAKKAGIPMVMHVR-ELVEFDNDLAD----LLRESPQRthaRVIATSDYFIANSEETARWI---NEPERTTVIYNCVDT- 742
Cdd:cd03821  110 LARRRGIPYVVSPHgMLDPWALQQKHwkkrIALHLIER---RNLNNAALVHFTSEQEADELrrfGLEPPIAVIPNGVDIp 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 743 ------SPSQNSMPSGALKICMLSSNV-KKKGVEDFFEVA-SLCKEASNIQFTIYGPITNEVIMAAKRFGDAN----ITI 810
Cdd:cd03821  187 efdpglRDRRKHNGLEDRRIILFLGRIhPKKGLDLLIRAArKLAEQGRDWHLVIAGPDDGAYPAFLQLQSSLGlgdrVTF 266

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 811 AGYV--EKPKEAMAEHHI-VLAlSHfKESFGRTVAEAMSLGRVVVGYDWGAVNELVDKQSGILVDyKSTEKIVDAI---L 884
Cdd:cd03821  267 TGPLygEAKWALYASADLfVLP-SY-SENFGNVVAEALACGLPVVITDKCGLSELVEAGCGVVVD-PNVSSLAEALaeaL 343

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 407292567 885 DLNCNPKLVASMGNcAAKRAKELFSRDTFGKKLVN 919
Cdd:cd03821  344 RDPADRKRLGEMAR-RARQVEENFSWEAVAGQLGE 377
GT2_AmsE_like cd04195
GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; AmsE is a ...
 215-400 1.52e-05

GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; AmsE is a glycosyltransferase involved in exopolysaccharide amylovora biosynthesis in Erwinia amylovora. Amylovara is one of the three exopolysaccharide produced by E. amylovora. Amylovara-deficient mutants are non-pathogenic. It is a subfamily of Glycosyltransferase Family GT2, which includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds.


Pssm-ID: 133038 [Multi-domain]  Cd Length: 201  Bit Score: 46.92  E-value: 1.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 215 SIIVPVFNAEK--VISTSINSLLNQSWKNIEIIAVDDASTDNSY----TELKRLYGgidrVRIIKNNKNKGAYATRNLGM 288
Cdd:cd04195    1 SVLMSVYIKEKpeFLREALESILKQTLPPDEVVLVKDGPVTQSLnevlEEFKRKLP----LKVVPLEKNRGLGKALNEGL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 289 TLASGNFLTVMDADDWAHPQKIEKQVIPLLFNRSL-----------KGTVSHWVRCT-----EDLEFSRLRvgNSWVHRN 352
Cdd:cd04195   77 KHCTYDWVARMDTDDISLPDRFEKQLDFIEKNPEIdivgggvlefdSDGNDIGKRRLptshdDILKFARRR--SPFNHPT 154

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 407292567 353 VsslLVRKDVVASLGGWDEVKVNADTEFYERCLAKFGKAA-IKEVMPDV 400
Cdd:cd04195  155 V---MFRKSKVLAVGGYQDLPLVEDYALWARMLANGARFAnLPEILVKA 200
GT4_ALG2-like cd03805
alpha-1,3/1,6-mannosyltransferase ALG2 and similar proteins; This family is most closely ...
 835-917 1.74e-05

alpha-1,3/1,6-mannosyltransferase ALG2 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ALG2, a 1,3-mannosyltransferase, in yeast catalyzes the mannosylation of Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. A deficiency of this enzyme causes an abnormal accumulation of Man1GlcNAc2-PP-dolichol and Man2GlcNAc2-PP-dolichol, which is associated with a type of congenital disorders of glycosylation (CDG), designated CDG-Ii, in humans.


Pssm-ID: 340834 [Multi-domain]  Cd Length: 392  Bit Score: 47.97  E-value: 1.74e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 835 ESFGRTVAEAMSLGRVVVgydwgAVNE------LVDKQSGILVDyKSTEKIVDAILDLNCNPKLVASMGNCAAKRAKELF 908
Cdd:cd03805  310 EHFGIVPLEAMYAGKPVI-----ACNSggpletVVEGVTGFLCE-PTPEAFAEAMLKLANDPDLADRMGAAGRKRVKEKF 383


                 ....*....
gi 407292567 909 SRDTFGKKL 917
Cdd:cd03805  384 SREAFAERL 392
GT4-like cd05844
glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar ...
 697-917 5.93e-05

glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to glycosyltransferase family 4 (GT4). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340860 [Multi-domain]  Cd Length: 365  Bit Score: 46.29  E-value: 5.93e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 697 LLRESPQRTHARVIATSDyFIanseeTARWINE---PERTTVIYNCVDTSPSQNSMPSG-ALKICMLSSNVKKKGVEDFF 772
Cdd:cd05844  135 RHRRALQRPAALFVAVSG-FI-----RDRLLARglpAERIHVHYIGIDPAKFAPRDPAErAPTILFVGRLVEKKGCDVLI 208

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 773 E-VASLCKEASNIQFTIYG--PITNEviMAAKRFGDANITIAGYVEKPK--EAMAEHHI-----VLALSHFKESFGRTVA 842
Cdd:cd05844  209 EaFRRLAARHPTARLVIAGdgPLRPA--LQALAAALGRVRFLGALPHAEvqDWMRRAEIfclpsVTAASGDSEGLGIVLL 286

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 407292567 843 EAMSLGRVVVGYDWGAVNELV-DKQSGILVDYKSTEKIVDAILDLNCNPKLVASMGNCAAKRAKELFSRDTFGKKL 917
Cdd:cd05844  287 EAAACGVPVVSSRHGGIPEAIlDGETGFLVPEGDVDALADALQALLADRALADRMGGAARAFVCEQFDIRVQTAKL 362
GT4_ExpC-like cd03818
Rhizobium meliloti ExpC and similar proteins; This family is most closely related to the GT4 ...
 843-911 7.72e-05

Rhizobium meliloti ExpC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II).


Pssm-ID: 340845 [Multi-domain]  Cd Length: 396  Bit Score: 46.20  E-value: 7.72e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 843 EAMSLGRVVVGYDWGAVNELV-DKQSGILVDYKSTEKIVDAILDLNCNPKLVASMGNCAAKRAKELFSRD 911
Cdd:cd03818  319 EAMACGCPVIGSDTAPVREVIrDGRNGLLVDFFDPDALAAAVLELLEDPDRAAALRRAARRTVERSDSLD 388
GT_2_like_e cd04192
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 216-302 8.45e-05

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133035 [Multi-domain]  Cd Length: 229  Bit Score: 44.97  E-value: 8.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 216 IIVPVFNAEKVISTSINSLLNQSW--KNIEIIAVDDASTDNSYTELKRLYG-GIDRVRIIKNN--KNKGAYATRNLGMTL 290
Cdd:cd04192    1 VVIAARNEAENLPRLLQSLSALDYpkEKFEVILVDDHSTDGTVQILEFAAAkPNFQLKILNNSrvSISGKKNALTTAIKA 80

                         90
                 ....*....|..
gi 407292567 291 ASGNFLTVMDAD 302
Cdd:cd04192   81 AKGDWIVTTDAD 92
PRK10714 PRK10714
undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional
 213-314 1.20e-04

undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional


Pssm-ID: 182669 [Multi-domain]  Cd Length: 325  Bit Score: 45.11  E-value: 1.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 213 KVSIIVPVFNAEKVI------STSINSLLNQSWkniEIIAVDDASTDNSYTELKRLYGGID-RVRIIKNNKNKGAYATRN 285
Cdd:PRK10714   7 KVSVVIPVYNEQESLpelirrTTAACESLGKEY---EILLIDDGSSDNSAEMLVEAAQAPDsHIVAILLNRNYGQHSAIM 83

                         90       100
                 ....*....|....*....|....*....
gi 407292567 286 LGMTLASGNFLTVMDADDWAHPQKIEKQV 314
Cdd:PRK10714  84 AGFSHVTGDLIITLDADLQNPPEEIPRLV 112
Glyco_trans_1_2 pfam13524
Glycosyl transferases group 1;
826-906 1.42e-04

Glycosyl transferases group 1;


Pssm-ID: 433281 [Multi-domain]  Cd Length: 93  Bit Score: 41.44  E-value: 1.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567  826 IVLALSHFKESFGRTVAEAMSLGRVVVGYDWGAVNELVDKQSGILVdYKSTEKIVDAILDLNCNPKLVASMGNCAAKRAK 905
Cdd:pfam13524   1 IVLNPSRRPDSPNMRVFEAAACGAPLLTDRTPGLEELFEPGEEILL-YRDPEELAEKIRYLLEHPEERRAIAAAGRERVL 79


                  .
gi 407292567  906 E 906
Cdd:pfam13524  80 A 80
GT28_MurG cd03785
undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; MurG (EC 2.4. ...
 752-905 1.77e-04

undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; MurG (EC 2.4.1.227) is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide (NAM). The resulting disaccharide is then transported across the cell membrane, where it is polymerized into NAG-NAM cell-wall repeat structure. MurG belongs to the GT-B structural superfamily of glycoslytransferases, which have characteristic N- and C-terminal domains, each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340818 [Multi-domain]  Cd Length: 350  Bit Score: 44.90  E-value: 1.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 752 GALKICMLSSNVKKKgvedffevasLCKEasNIQFT-IYGPITNEVIMAAKRFGDANITIAGYVEKPKEAMAEHHIVLAL 830
Cdd:cd03785  192 GARAINRAVPKALPK----------LLER--GIQVIhQTGKGDYDEVKKLYEDLGINVKVFPFIDDMAAAYAAADLVISR 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 831 ShfkesfGR-TVAEAMSLGR--VVVGYDWGAVNE-------LVDKQSGILVDYK--STEKIVDAILDLNCNPKLVASMGN 898
Cdd:cd03785  260 A------GAsTIAELTAAGKpaILIPYPYAADDHqeanaraLEKAGAAIVIDQEelTPEVLAEAILDLLNDPERLKKMAE 333


                 ....*..
gi 407292567 899 CAAKRAK 905
Cdd:cd03785  334 AAKKLAK 340
PRK15484 PRK15484
lipopolysaccharide N-acetylglucosaminyltransferase;
777-921 2.51e-04

lipopolysaccharide N-acetylglucosaminyltransferase;


Pssm-ID: 185381 [Multi-domain]  Cd Length: 380  Bit Score: 44.40  E-value: 2.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 777 LCKEASNIQFTIYGPITN-----------EVIMAAKRFGDANITIAGyveKPKEAMAEHH----IVLALSHFKESFGRTV 841
Cdd:PRK15484 218 LATAHSNLKLVVVGDPTAsskgekaayqkKVLEAAKRIGDRCIMLGG---QPPEKMHNYYpladLVVVPSQVEEAFCMVA 294

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 842 AEAMSLGRVVVGYDWGAVNELV-DKQSGI-LVDYKSTEKIVDAILDLNCNPKLvASMGNCAAKRAKELFSRDTFGKKLVN 919
Cdd:PRK15484 295 VEAMAAGKPVLASTKGGITEFVlEGITGYhLAEPMTSDSIISDINRTLADPEL-TQIAEQAKDFVFSKYSWEGVTQRFEE 373


                 ..
gi 407292567 920 QI 921
Cdd:PRK15484 374 QI 375
GT_2_like_b cd04185
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 231-312 2.98e-04

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133028 [Multi-domain]  Cd Length: 202  Bit Score: 43.01  E-value: 2.98e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 231 INSLLNQSWKNIEIIAVDDASTDNSYTELKRLyGGIDRVRIIKNNKNKGAYATRNLGMTLA--SG-NFLTVMDADDWAHP 307
Cdd:cd04185   16 LDALLAQTRPPDHIIVIDNASTDGTAEWLTSL-GDLDNIVYLRLPENLGGAGGFYEGVRRAyeLGyDWIWLMDDDAIPDP 94


                 ....*
gi 407292567 308 QKIEK 312
Cdd:cd04185   95 DALEK 99
GlcNAc-1-P_transferase cd06436
N-acetyl-glucosamine transferase is involved in the synthesis of Poly-beta-1, ...
 216-368 1.02e-03

N-acetyl-glucosamine transferase is involved in the synthesis of Poly-beta-1,6-N-acetyl-D-glucosamine; N-acetyl-glucosamine transferase is responsible for the synthesis of bacteria Poly-beta-1,6-N-acetyl-D-glucosamine (PGA). Poly-beta-1,6-N-acetyl-D-glucosamine is a homopolymer that serves as an adhesion for the maintenance of biofilm structural stability in diverse eubacteria. N-acetyl-glucosamine transferase is the product of gene pgaC. Genetic analysis indicated that all four genes of the pgaABCD locus were required for the PGA production, pgaC being a glycosyltransferase.


Pssm-ID: 133058 [Multi-domain]  Cd Length: 191  Bit Score: 41.22  E-value: 1.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 216 IIVPVFNAEKVISTSINSLLNQSwKNIEIIAVDDASTDNSyTELKRLYGGIDRVRIIKNNK-----------NKGAYATR 284
Cdd:cd06436    1 VLVPCLNEEAVIQRTLASLLRNK-PNFLVLVIDDASDDDT-AGIVRLAITDSRVHLLRRHLpnartgkgdalNAAYDQIR 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 285 NLGmTLASGNF----LTVMDADDWAHPQKIEKqVIPLLFNRSLKGT---------VSHWVRCTEDLEFsrlrvgnsWVHR 351
Cdd:cd06436   79 QIL-IEEGADPerviIAVIDADGRLDPNALEA-VAPYFSDPRVAGTqsrvrmynrHKNLLTILQDLEF--------FIII 148

                        170
                 ....*....|....*..
gi 407292567 352 NVSSLLVRKDVVASLGG 368
Cdd:cd06436  149 AATQSLRALTGTVGLGG 165
CESA_CaSu_A2 cd06437
Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit ...
 214-323 1.11e-03

Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit substitute of the cellulose synthase complex; Cellulose synthase (CESA) catalyzes the polymerization reaction of cellulose using UDP-glucose as the substrate. Cellulose is an aggregate of unbranched polymers of beta-1,4-linked glucose residues, which is an abundant polysaccharide produced by plants and in varying degrees by several other organisms including algae, bacteria, fungi, and even some animals. Genomes from higher plants harbor multiple CESA genes. There are ten in Arabidopsis. At least three different CESA proteins are required to form a functional complex. In Arabidopsis, CESA1, 3 and 6 and CESA4, 7 and 8, are required for cellulose biosynthesis during primary and secondary cell wall formation. CESA2 is very closely related to CESA6 and is viewed as a prime substitute for CESA6. They functionally compensate each other. The cesa2 and cesa6 double mutant plants were significantly smaller, while the single mutant plants were almost normal.


Pssm-ID: 133059 [Multi-domain]  Cd Length: 232  Bit Score: 41.53  E-value: 1.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 214 VSIIVPVFNAEKVISTSINSLLNQSW-KNIEIIAVDDASTDNSYTELKRLYG-----GIDRVRIIKNNKN---KGAYATr 284
Cdd:cd06437    3 VTVQLPVFNEKYVVERLIEAACALDYpKDRLEIQVLDDSTDETVRLAREIVEeyaaqGVNIKHVRRADRTgykAGALAE- 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 407292567 285 nlGMTLASGNFLTVMDAD-----DWAHpqkiekQVIPLLFNRSL 323
Cdd:cd06437   82 --GMKVAKGEYVAIFDADfvpppDFLQ------KTPPYFADPKL 117
Glyco_trans_4_4 pfam13579
Glycosyl transferase 4-like domain;
583-738 1.45e-03

Glycosyl transferase 4-like domain;


Pssm-ID: 433325 [Multi-domain]  Cd Length: 158  Bit Score: 40.08  E-value: 1.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567  583 GAERSLVDIAEAMQKANISITLFLPSCSNITY-IEELKQFVRKIVFLPLPWANGREEPIQPVAQYLESDflhcGYDCVYV 661
Cdd:pfam13579   2 GIGVYVLELARALAALGHEVRVVTPGGPPGRPeLVGDGVRVHRLPVPPRPSPLADLAALRRLRRLLRAE----RPDVVHA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567  662 NTLTLiePLS---AAKKAGIPMVMHVRelvefDNDLADLLRESPQ---RTHARVIATSDYFIANSEETARWI----NEPE 731
Cdd:pfam13579  78 HSPTA--GLAarlARRRRGVPLVVTVH-----GLALDYGSGWKRRlarALERRLLRRADAVVVVSEAEAELLralgVPAA 150


                  ....*..
gi 407292567  732 RTTVIYN 738
Cdd:pfam13579 151 RVVVVPN 157
GT4_PIG-A-like cd03796
phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins; This ...
 730-885 2.69e-03

phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Phosphatidylinositol glycan-class A (PIG-A), an X-linked gene in humans, is necessary for the synthesis of N-acetylglucosaminyl-phosphatidylinositol, a very early intermediate in glycosyl phosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is an important cellular structure that facilitates the attachment of many proteins to cell surfaces. Somatic mutations in PIG-A have been associated with Paroxysmal Nocturnal Hemoglobinuria (PNH), an acquired hematological disorder.


Pssm-ID: 340827 [Multi-domain]  Cd Length: 398  Bit Score: 41.07  E-value: 2.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 730 PERTTVIYNCVDTS---PSQNSMPSGALKICMLSSNVKKKGVEDFFEVAS-LCKEASNIQFTI--YGP---ITNEVImaa 800
Cdd:cd03796  167 PRIVSVIPNAVDSSdftPDPSKPDPNKITIVVISRLVYRKGIDLLVGIIPrICKKHPNVRFIIggDGPkriELEEMR--- 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 801 KRFGDAN-ITIAGYV--EKPKEAMAEHHIVLALShFKESFGRTVAEAMSLGRVVVGYDWGAVNElVDKQSGILVDYKSTE 877
Cdd:cd03796  244 EKYQLQDrVELLGAVphEEVRDVLVQGHIFLNTS-LTEAFCIAIVEAASCGLLVVSTRVGGIPE-VLPPDMILLAEPDPE 321


                 ....*...
gi 407292567 878 KIVDAILD 885
Cdd:cd03796  322 DIVRKLEE 329
GT2_Chondriotin_Pol_N cd06420
N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Chondroitin ...
 216-312 2.91e-03

N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Chondroitin polymerase is a two domain, bi-functional protein. The N-terminal domain functions as a GalNAc transferase. The bacterial chondroitin polymerase catalyzes elongation of the chondroitin chain by alternatively transferring the GlcUA and GalNAc moiety from UDP-GlcUA and UDP-GalNAc to the non-reducing ends of the chondroitin chain. The enzyme consists of N-terminal and C-terminal domains in which the two active sites catalyze the addition of GalNAc and GlcUA, respectively. Chondroitin chains range from 40 to over 100 repeating units of the disaccharide. Sulfated chondroitins are involved in the regulation of various biological functions such as central nervous system development, wound repair, infection, growth factor signaling, and morphogenesis, in addition to its conventional structural roles. In Caenorhabditis elegans, chondroitin is an essential factor for the worm to undergo cytokinesis and cell division. Chondroitin is synthesized as proteoglycans, sulfated and secreted to the cell surface or extracellular matrix.


Pssm-ID: 133042 [Multi-domain]  Cd Length: 182  Bit Score: 39.87  E-value: 2.91e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 216 IIVPVFNAEKVISTSINSLLNQSWKNIEIIAVDDASTDNSyTELKRLYGGIDRVRIIKN-NKNKG--AYATRNLGMTLAS 292
Cdd:cd06420    1 LIITTYNRPEALELVLKSVLNQSILPFEVIIADDGSTEET-KELIEEFKSQFPIPIKHVwQEDEGfrKAKIRNKAIAAAK 79

                         90       100
                 ....*....|....*....|
gi 407292567 293 GNFLTVMDADDWAHPQKIEK 312
Cdd:cd06420   80 GDYLIFIDGDCIPHPDFIAD 99
GT4_UGDG-like cd03817
UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most ...
 734-906 2.97e-03

UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (EC 2.4.1.337, UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-diacylglycerol forming 3-D-glucosyl-1,2-diacylglycerol.


Pssm-ID: 340844 [Multi-domain]  Cd Length: 372  Bit Score: 41.11  E-value: 2.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 734 TVIYNCVDTSPSQNSMPSGALK----------ICMLSSNVKKKGVEDFFEVASLCKEASNIQFTIYG--PITNEVIMAAK 801
Cdd:cd03817  172 EVIPNGIDLDKFEKPLNTEERRklglppdepiLLYVGRLAKEKNIDFLLRAFAELKKEPNIKLVIVGdgPEREELKELAR 251

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 802 RFG-DANITIAGYV--EKPKEAMAEHHIVLALSHfKESFGRTVAEAMSLGRVVVGYDWGAVNELV-DKQSGILVDyKSTE 877
Cdd:cd03817  252 ELGlADKVIFTGFVprEELPEYYKAADLFVFAST-TETQGLVYLEAMAAGLPVVAAKDPAASELVeDGENGFLFE-PNDE 329

                        170       180
                 ....*....|....*....|....*....
gi 407292567 878 KIVDAILDLNCNPKLVASMGNCAAKRAKE 906
Cdd:cd03817  330 TLAEKLLHLRENLELLRKLSKNAEISARE 358
GT4_trehalose_phosphorylase cd03792
trehalose phosphorylase and similar proteins; Trehalose phosphorylase (TP) reversibly ...
 825-908 4.99e-03

trehalose phosphorylase and similar proteins; Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose, and the subsequent synthesis of trehalose. This family is most closely related to the GT4 family of glycosyltransferases.


Pssm-ID: 340823 [Multi-domain]  Cd Length: 378  Bit Score: 40.38  E-value: 4.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 825 HIVLALShFKESFGRTVAEAMSLGRVVVGYDWGAVN-ELVDKQSGILVDykSTEKIVDAILDLNCNPKLVASMGNCAAKR 903
Cdd:cd03792  281 TVVLQLS-TREGFGLTVSEALWKGKPVIATPAGGIPlQVIDGETGFLVN--SVEGAAVRILRLLTDPELRRKMGLAAREH 357


                 ....*
gi 407292567 904 AKELF 908
Cdd:cd03792  358 VRDNF 362
EpsO_like cd06438
EpsO protein participates in the methanolan synthesis; The Methylobacillus sp EpsO protein is ...
 216-307 7.38e-03

EpsO protein participates in the methanolan synthesis; The Methylobacillus sp EpsO protein is predicted to participate in the methanolan synthesis. Methanolan is an exopolysaccharide (EPS), composed of glucose, mannose and galactose. A 21 genes cluster was predicted to participate in the methanolan synthesis. Gene disruption analysis revealed that EpsO is one of the glycosyltransferase enzymes involved in the synthesis of repeating sugar units onto the lipid carrier.


Pssm-ID: 133060 [Multi-domain]  Cd Length: 183  Bit Score: 38.35  E-value: 7.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 407292567 216 IIVPVFNAEKVISTSINSLLNQSWK--NIEIIAVDDASTDNSyTELKRLYGGIDRVRIIKNNKNKG---AYATRNLGMTL 290
Cdd:cd06438    1 ILIPAHNEEAVIGNTVRSLKAQDYPreLYRIFVVADNCTDDT-AQVARAAGATVLERHDPERRGKGyalDFGFRHLLNLA 79

                         90
                 ....*....|....*..
gi 407292567 291 ASGNFLTVMDADDWAHP 307
Cdd:cd06438   80 DDPDAVVVFDADNLVDP 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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