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Conserved domains on  [gi|392303278|gb|AFM55891|]
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ectodermal-neural cortex 1-like protein, partial [Chologaster cornuta]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BACK super family cl28903
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 4-101 2.64e-69

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


The actual alignment was detected with superfamily member cd18515:

Pssm-ID: 475122 [Multi-domain]  Cd Length: 98  Bit Score: 208.68  E-value: 2.64e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278   4 HPSNCLGMLLLSDAHQCAKLSELSWGMCLSNFPAICKTEDFLQLPKDMVVQLLSHEELETEDERLVYEAALGWLNYDLDG 83
Cdd:cd18515    1 HPTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTICKTEDFLQLPKDMVVQLLSSEELETEDERLVYEAAINWVNYDLKK 80

                         90
                 ....*....|....*...
gi 392303278  84 RHCHLPELLQTVRLALLP 101
Cdd:cd18515   81 RHCYLSELLQTVRLALLP 98
PHA03098 super family cl33709
kelch-like protein; Provisional
 1-254 4.81e-17

kelch-like protein; Provisional


The actual alignment was detected with superfamily member PHA03098:

Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 80.20  E-value: 4.81e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278   1 RNLHPSNCLGMLLLSDAHQCAKLSELSWGMCLSNFPAICKTEDFLQLPKDMVVQLLSHEELETEDERLVYEAALGWLNYD 80
Cdd:PHA03098 103 KIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSDDKLNVSSEDVVLEIIIKWLTSK 182

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278  81 LDGRHCHLPELLQTVRLALLpaiflmenvsTEELINSQARSKelvdEAIRCKLKILQNDGVV-------NSPCARPRKTS 153
Cdd:PHA03098 183 KNNKYKDICLILKVLRITFL----------SEEGIKKLKRWK----LRIKKKKIVFNKRCIKiiyskkyNLNKILPRSST 248

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278 154 HALFLLGGQTFMCDKLYLVDQKAKEIIPKADIPSPRKEFSACA-IGCRVYITGGRGSENGVSKDVWVYDTVHEEWSKAAP 232
Cdd:PHA03098 249 FGSIIYIHITMSIFTYNYITNYSPLSEINTIIDIHYVYCFGSVvLNNVIYFIGGMNKNNLSVNSVVSYDTKTKSWNKVPE 328

                        250       260
                 ....*....|....*....|..
gi 392303278 233 MLIARFGHGSAELKHCLYVVGG 254
Cdd:PHA03098 329 LIYPRKNPGVTVFNNRIYVIGG 350
 
Name Accession Description Interval E-value
BACK_KLHL37_ENC1 cd18515
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also ...
 4-101 2.64e-69

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350590 [Multi-domain]  Cd Length: 98  Bit Score: 208.68  E-value: 2.64e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278   4 HPSNCLGMLLLSDAHQCAKLSELSWGMCLSNFPAICKTEDFLQLPKDMVVQLLSHEELETEDERLVYEAALGWLNYDLDG 83
Cdd:cd18515    1 HPTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTICKTEDFLQLPKDMVVQLLSSEELETEDERLVYEAAINWVNYDLKK 80

                         90
                 ....*....|....*...
gi 392303278  84 RHCHLPELLQTVRLALLP 101
Cdd:cd18515   81 RHCYLSELLQTVRLALLP 98
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 8-109 1.11e-35

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 123.04  E-value: 1.11e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278    8 CLGMLLLSDAHQCAKLSELSWGMCLSNFPAICKTEDFLQLPKDMVVQLLSHEELETEDERLVYEAALGWLNYDLDGRHCH 87
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|..
gi 392303278   88 LPELLQTVRLALLPAIFLMENV 109
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLV 102
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 8-108 4.54e-31

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 110.89  E-value: 4.54e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278     8 CLGMLLLSDAHQCAKLSELSWGMCLSNFPAICKTEDFLQLPKDMVVQLLSHEELETEDERLVYEAALGWLNYDLDGRHCH 87
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90       100
                   ....*....|....*....|.
gi 392303278    88 LPELLQTVRLALLPAIFLMEN 108
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLEV 101
PHA03098 PHA03098
kelch-like protein; Provisional
 1-254 4.81e-17

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 80.20  E-value: 4.81e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278   1 RNLHPSNCLGMLLLSDAHQCAKLSELSWGMCLSNFPAICKTEDFLQLPKDMVVQLLSHEELETEDERLVYEAALGWLNYD 80
Cdd:PHA03098 103 KIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSDDKLNVSSEDVVLEIIIKWLTSK 182

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278  81 LDGRHCHLPELLQTVRLALLpaiflmenvsTEELINSQARSKelvdEAIRCKLKILQNDGVV-------NSPCARPRKTS 153
Cdd:PHA03098 183 KNNKYKDICLILKVLRITFL----------SEEGIKKLKRWK----LRIKKKKIVFNKRCIKiiyskkyNLNKILPRSST 248

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278 154 HALFLLGGQTFMCDKLYLVDQKAKEIIPKADIPSPRKEFSACA-IGCRVYITGGRGSENGVSKDVWVYDTVHEEWSKAAP 232
Cdd:PHA03098 249 FGSIIYIHITMSIFTYNYITNYSPLSEINTIIDIHYVYCFGSVvLNNVIYFIGGMNKNNLSVNSVVSYDTKTKSWNKVPE 328

                        250       260
                 ....*....|....*....|..
gi 392303278 233 MLIARFGHGSAELKHCLYVVGG 254
Cdd:PHA03098 329 LIYPRKNPGVTVFNNRIYVIGG 350
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
181-260 2.12e-14

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 70.96  E-value: 2.12e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278 181 PKADIPSPRKEFSACAIGCRVYITGGRgSENGVSKDVWVYDTVHEEWSKAAPM-LIARFGHGSAELKHCLYVVGGHTAAT 259
Cdd:COG3055    5 SLPDLPTPRSEAAAALLDGKVYVAGGL-SGGSASNSFEVYDPATNTWSELAPLpGPPRHHAAAVAQDGKLYVFGGFTGAN 83


                 .
gi 392303278 260 G 260
Cdd:COG3055   84 P 84
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 188-233 2.06e-09

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 52.23  E-value: 2.06e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 392303278  188 PRKEFSACAIGCRVYITGGRGSENGVSkDVWVYDTVHEEWSKAAPM 233
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLN-SVEVYDPETNTWSKLPSM 45
Kelch smart00612
Kelch domain;
200-243 8.77e-08

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 47.55  E-value: 8.77e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 392303278   200 RVYITGGRGSENgVSKDVWVYDTVHEEWSKAAPMLIARFGHGSA 243
Cdd:smart00612   1 KIYVVGGFDGGQ-RLKSVEVYDPETNKWTPLPSMPTPRSGHGVA 43
 
Name Accession Description Interval E-value
BACK_KLHL37_ENC1 cd18515
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also ...
 4-101 2.64e-69

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350590 [Multi-domain]  Cd Length: 98  Bit Score: 208.68  E-value: 2.64e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278   4 HPSNCLGMLLLSDAHQCAKLSELSWGMCLSNFPAICKTEDFLQLPKDMVVQLLSHEELETEDERLVYEAALGWLNYDLDG 83
Cdd:cd18515    1 HPTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTICKTEDFLQLPKDMVVQLLSSEELETEDERLVYEAAINWVNYDLKK 80

                         90
                 ....*....|....*...
gi 392303278  84 RHCHLPELLQTVRLALLP 101
Cdd:cd18515   81 RHCYLSELLQTVRLALLP 98
BACK_KLHL25_like cd18464
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The ...
 4-101 2.33e-56

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The family includes KLHL25 and KLHL37. KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350539 [Multi-domain]  Cd Length: 98  Bit Score: 175.76  E-value: 2.33e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278   4 HPSNCLGMLLLSDAHQCAKLSELSWGMCLSNFPAICKTEDFLQLPKDMVVQLLSHEELETEDERLVYEAALGWLNYDLDG 83
Cdd:cd18464    1 HPSNCLGMLLLSDAHQCQRLYELSWRMCLANFTTLRKTEDFLSLPKDKLLELVSSEELEVEDERLVYEAVIGWIRYDLPR 80

                         90
                 ....*....|....*...
gi 392303278  84 RHCHLPELLQTVRLALLP 101
Cdd:cd18464   81 RHEVLPELLRSVRLALLP 98
BACK_KLHL25_ENC2 cd18514
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also ...
 3-101 3.01e-44

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1).


Pssm-ID: 350589 [Multi-domain]  Cd Length: 99  Bit Score: 144.99  E-value: 3.01e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278   3 LHPSNCLGMLLLSDAHQCAKLSELSWGMCLSNFPAICKTEDFLQLPKDMVVQLLSHEELETEDERLVYEAALGWLNYDLD 82
Cdd:cd18514    1 LHPSNCLGMMLLSDAHQCRRLYELSWRMCLVHFETVRESEDFYSLSKDKLLDLISSDELEIEDEQVVFNAVLQWVKYDLE 80

                         90
                 ....*....|....*....
gi 392303278  83 GRHCHLPELLQTVRLALLP 101
Cdd:cd18514   81 KRKDYLPELLRNVRLALLP 99
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 8-109 1.11e-35

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 123.04  E-value: 1.11e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278    8 CLGMLLLSDAHQCAKLSELSWGMCLSNFPAICKTEDFLQLPKDMVVQLLSHEELETEDERLVYEAALGWLNYDLDGRHCH 87
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|..
gi 392303278   88 LPELLQTVRLALLPAIFLMENV 109
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLV 102
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 8-108 4.54e-31

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 110.89  E-value: 4.54e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278     8 CLGMLLLSDAHQCAKLSELSWGMCLSNFPAICKTEDFLQLPKDMVVQLLSHEELETEDERLVYEAALGWLNYDLDGRHCH 87
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90       100
                   ....*....|....*....|.
gi 392303278    88 LPELLQTVRLALLPAIFLMEN 108
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLEV 101
BACK_KLHL2_like cd18445
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ...
 3-115 3.55e-29

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.


Pssm-ID: 350520 [Multi-domain]  Cd Length: 114  Bit Score: 106.55  E-value: 3.55e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278   3 LHPSNCLGMLLLSDAHQCAKLSELSWGMCLSNFPAICKTEDFLQLPKDMVVQLLSHEELETEDERLVYEAALGWLNYDLD 82
Cdd:cd18445    1 LHPSNCLGIRAFADLHSCTDLLKYAQTYTEQHFSEVVKGEEFLLLSKEQVCELISSDDLTVPSEEKVFEAVMSWVNHDPE 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 392303278  83 GRHCHLPELLQTVRLALLPAIFLMENVSTEELI 115
Cdd:cd18445   81 NRKEHLAELLEHVRLPLLSPEYLVQRVEEEELI 113
BACK_KLHL29_KBTBD9 cd18468
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also ...
 4-105 1.02e-28

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also termed Kelch repeat and BTB domain-containing protein 9 (KBTBD9), belongs to the KLHL family. Its function remains unclear. A nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 (KLHL29) fusion transcript may participate in the origin or progression of some colon cancers.


Pssm-ID: 350543 [Multi-domain]  Cd Length: 102  Bit Score: 104.80  E-value: 1.02e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278   4 HPSNCLGMLLLSDAHQCAKLSELSWGMCLSNFPAICKTEDFLQLPKDMVVQLLSHEELETEDERLVYEAALGWLNYDLDG 83
Cdd:cd18468    1 TPSNCLGIWALAEALQCTELHNMAKAYALQNFPDVARQEEILSISKDDIVEYLSHDSLNTKAEELVFETAIKWLKKDPKN 80

                         90       100
                 ....*....|....*....|..
gi 392303278  84 RHCHLPELLQTVRLALLPAIFL 105
Cdd:cd18468   81 RKQHIAELLAVVRLPFIHPSYL 102
BACK_KLHL3 cd18513
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as ...
 3-130 2.35e-26

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.


Pssm-ID: 350588 [Multi-domain]  Cd Length: 130  Bit Score: 99.76  E-value: 2.35e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278   3 LHPSNCLGMLLLSDAHQCAKLSELSWGMCLSNFPAICKTEDFLQLPKDMVVQLLSHEELETEDERLVYEAALGWLNYDLD 82
Cdd:cd18513    1 LHPTNCLGIRAFADVHTCTELLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWIKYDKE 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 392303278  83 GRHCHLPELLQTVRLALLPAIFLMENVSTEELINSQARSKELVDEAIR 130
Cdd:cd18513   81 ARLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMK 128
BACK_KLHL12 cd18452
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also ...
 3-134 6.53e-26

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.


Pssm-ID: 350527 [Multi-domain]  Cd Length: 136  Bit Score: 98.62  E-value: 6.53e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278   3 LHPSNCLGMLLLSDAHQCAKLSELSWGMCLSNFPAICKTEDFLQLPKDMVVQLLSHEELETEDERLVYEAALGWLNYDLD 82
Cdd:cd18452    1 LDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFMLLSQEEVEKLIKSDEIQVDSEEPVFEAVLNWVKHDKE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 392303278  83 GRHCHLPELLQTVRLALLPAIFLMENVSTEELINSQARSKELVDEAIRCKLK 134
Cdd:cd18452   81 EREDYLPELLQYVRLPLLSPRYITDVVDAEPLIRCSLECRDLVDEAKKFHLR 132
BACK_KLHL1_like cd18444
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; ...
 3-107 1.12e-25

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This subfamily contains Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. Members of this subfamily contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels.


Pssm-ID: 350519 [Multi-domain]  Cd Length: 106  Bit Score: 97.02  E-value: 1.12e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278   3 LHPSNCLGMLLLSDAHQCAKLSELSWGMCLSNFPAICKTEDFLQLPKDMVVQLLSHEELETEDERLVYEAALGWLNYDLD 82
Cdd:cd18444    2 LHPSNCLGIRSFADAQGCTDLLKVAHNYTMEHFMEVIQNQEFLLLPAEEVAKLLASDDLNVPSEETIFHALLLWVKHDLP 81

                         90       100
                 ....*....|....*....|....*
gi 392303278  83 GRHCHLPELLQTVRLALLPAIFLME 107
Cdd:cd18444   82 ERKKHLAKLLALIRLPLLTPQFLAD 106
BACK_KLHL2_Mayven cd18512
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also ...
 3-130 4.91e-25

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.


Pssm-ID: 350587 [Multi-domain]  Cd Length: 130  Bit Score: 96.25  E-value: 4.91e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278   3 LHPSNCLGMLLLSDAHQCAKLSELSWGMCLSNFPAICKTEDFLQLPKDMVVQLLSHEELETEDERLVYEAALGWLNYDLD 82
Cdd:cd18512    1 LHPTNCLGIRAFADMHACTELLNQANTYAEQHFSDVVLSEEFLNLGIEQVCSLIASDKLTISSEEKVFEAVIAWVNHDKE 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 392303278  83 GRHCHLPELLQTVRLALLPAIFLMENVSTEELINSQARSKELVDEAIR 130
Cdd:cd18512   81 VRQEHMAHLMEHVRLPLLSREYLVQRVEEETLVKNSSACKDYLIEAMK 128
BACK_KLHL18 cd18457
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as ...
 3-109 1.79e-23

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A.


Pssm-ID: 350532 [Multi-domain]  Cd Length: 107  Bit Score: 91.60  E-value: 1.79e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278   3 LHPSNCLGMLLLSDAHQCAKLSELSWGMCLSNFPAICKTEDFLQLPKDMVVQLLSHEELETEDERLVYEAALGWLNYDLD 82
Cdd:cd18457    1 LHPNNCLGIRQFAETMMCSSLVDAANKYIQQHFIEVSKSEEFLALSKEEVLEILSRDELNVKSEEQVFEAALAWVKYDRE 80

                         90       100
                 ....*....|....*....|....*..
gi 392303278  83 GRHCHLPELLQTVRLALLPAIFLMENV 109
Cdd:cd18457   81 NREEYLPELLSKVRLPLLRPQFLTDRV 107
BACK_KLHL30 cd18469
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs ...
 3-102 5.31e-22

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs to the KLHL family. Its function remains unclear. Differential expression of the KLHL30 gene has been observed in glioblastoma multiforme versus normal brain.


Pssm-ID: 350544 [Multi-domain]  Cd Length: 104  Bit Score: 87.50  E-value: 5.31e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278   3 LHPSNCLGMLLLSDAHQCAKLSELSWGMCLSNFPAICKTEDFLQLPKDMVVQLLSHEELETEDERLVYEAALGWLNYDLD 82
Cdd:cd18469    3 IDATNCLGICEFGETHGCPEVAAKAWSFLLENFEAVSQEEEFLQLEKERLVACLGDDLLQVRDEQSRLEAVLRWVGHDPQ 82

                         90       100
                 ....*....|....*....|
gi 392303278  83 GRHCHLPELLQTVRLALLPA 102
Cdd:cd18469   83 ARAAHLPELLSLVHLSLLTD 102
BACK_KLHL1 cd18509
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a ...
 3-107 4.23e-21

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton in brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350584 [Multi-domain]  Cd Length: 106  Bit Score: 85.46  E-value: 4.23e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278   3 LHPSNCLGMLLLSDAHQCAKLSELSWGMCLSNFPAICKTEDFLQLPKDMVVQLLSHEELETEDERLVYEAALGWLNYDLD 82
Cdd:cd18509    2 LHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQ 81

                         90       100
                 ....*....|....*....|....*
gi 392303278  83 GRHCHLPELLQTVRLALLPAIFLME 107
Cdd:cd18509   82 RRCSDLSMLLAYIRLPLLPPQLLAD 106
BACK_KLHL6 cd18446
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a ...
 3-109 6.26e-21

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation.


Pssm-ID: 350521 [Multi-domain]  Cd Length: 108  Bit Score: 84.83  E-value: 6.26e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278   3 LHPSNCLGMLLLSDAHQCAKLSELSWGMCLSNFPAICKTEDFLQLPKDMVVQLLSHEELETEDERLVYEAALGWLNYDLD 82
Cdd:cd18446    1 LHPENCVGILRLADAHSLESLKKQVQNYIIQNFSQVLNHEEFLELPVDILCHILKSDDLYVTEEEQVFETVMRWVRYKES 80

                         90       100
                 ....*....|....*....|....*..
gi 392303278  83 GRHCHLPELLQTVRLALLPAIFLMENV 109
Cdd:cd18446   81 ERLPLLPRVLENVRLPLLDPWYFVETV 107
BACK_KLHL20 cd18459
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also ...
 3-100 1.00e-19

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also termed Kelch-like ECT2-interacting protein (KLEIP), or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis.


Pssm-ID: 350534 [Multi-domain]  Cd Length: 100  Bit Score: 81.32  E-value: 1.00e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278   3 LHPSNCLGMLLLSDAHQCAKLSELSWGMCLSNFPAICKTEDFLQLPKDMVVQLLSHEELETEDERLVYEAALGWLNYDLD 82
Cdd:cd18459    2 LDPSNCLGIRAFADTHACRELLRIADKFTQHNFQEVMESEEFMLLPVNQLIDIISSDELNVRSEEQVFNAVMAWVKYNIQ 81

                         90
                 ....*....|....*...
gi 392303278  83 GRHCHLPELLQTVRLALL 100
Cdd:cd18459   82 ERRPHLPQVLQHVRLPLL 99
BACK_KLHL17 cd18456
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also ...
 3-104 1.29e-19

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also termed actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GluR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in the actin-based neuronal function.


Pssm-ID: 350531 [Multi-domain]  Cd Length: 102  Bit Score: 81.20  E-value: 1.29e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278   3 LHPSNCLGMLLLSDAHQCAKLSELSWGMCLSNFPAICKTEDFLQLPKDMVVQLLSHEELETEDERLVYEAALGWLNYDLD 82
Cdd:cd18456    1 LDPSNCLGIRGFADTHSCSDLLKSAHKYVLQHFVEVSKTEEFMLLPLKQVLDLISSDSLNVPSEEEVYRAVLSWVKHDVD 80

                         90       100
                 ....*....|....*....|..
gi 392303278  83 GRHCHLPELLQTVRLALLPAIF 104
Cdd:cd18456   81 GRRQHVPRLMKCVRLPLLSRDF 102
BACK_KLHL5 cd18511
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares ...
 3-107 3.94e-19

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. It is abundantly expressed in ovary, adrenal gland, and thymus.


Pssm-ID: 350586 [Multi-domain]  Cd Length: 106  Bit Score: 80.11  E-value: 3.94e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278   3 LHPSNCLGMLLLSDAHQCAKLSELSWGMCLSNFPAICKTEDFLQLPKDMVVQLLSHEELETEDERLVYEAALGWLNYDLD 82
Cdd:cd18511    2 LHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFLLLPASEIAKLLASDDMNIPNEETILNALLSWVRHDVE 81

                         90       100
                 ....*....|....*....|....*
gi 392303278  83 GRHCHLPELLQTVRLALLPAIFLME 107
Cdd:cd18511   82 QRRKDLSKLLAYIRLPLLAPQFLAD 106
BACK_KLHL8 cd18448
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...
 3-98 9.20e-19

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.


Pssm-ID: 350523 [Multi-domain]  Cd Length: 97  Bit Score: 78.89  E-value: 9.20e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278   3 LHPSNCLGMLLLSDAHQCAKLSELSWGMCLSNFPAICKTEDFLQLPKDMVVQLLSHEELETEDERLVYEAALGWLNYDLD 82
Cdd:cd18448    2 LHPSNCLGVRTFAEQHNRVDLMKMADKYACDHFNEVVECEEFVSISAQHLEKLISSSDLNVESESQVYEAVMKWVKHDPQ 81

                         90
                 ....*....|....*.
gi 392303278  83 GRHCHLPELLQTVRLA 98
Cdd:cd18448   82 HRKRHLDDLLSQVRLP 97
BACK_KLHL4 cd18510
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares ...
 3-107 3.22e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350585 [Multi-domain]  Cd Length: 106  Bit Score: 77.65  E-value: 3.22e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278   3 LHPSNCLGMLLLSDAHQCAKLSELSWGMCLSNFPAICKTEDFLQLPKDMVVQLLSHEELETEDERLVYEAALGWLNYDLD 82
Cdd:cd18510    2 LHPSNCLGIRSFGDAQGCTELLKVAHSYTMEHFLEVIKNQEFLLLPASEIVKLLASDDINVPDEETIFQALMMWVRHDLQ 81

                         90       100
                 ....*....|....*....|....*
gi 392303278  83 GRHCHLPELLQTVRLALLPAIFLME 107
Cdd:cd18510   82 NRQKDLGMLLSYIRLPLLPPQLLAD 106
BACK_KLHL27_IPP cd18466
BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide ...
 5-102 3.73e-18

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also termed Kelch-like protein 27 (KLHL27), is an actin-binding protein that may play a role in organizing the actin cytoskeleton.


Pssm-ID: 350541 [Multi-domain]  Cd Length: 103  Bit Score: 77.52  E-value: 3.73e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278   5 PSNCLGMLLLSDAHQCAKLSELSWGMCLSNFPAICKTEDFLQLPKDMVVQLLSHEELETEDERLVYEAALGWLNYDLDGR 84
Cdd:cd18466    3 PANCIGIFQFSEQIACHDLLEFTENYIHVHFLEVQSGEEFLGLTKDQLVKILRSEELSIEDEYQVFTAAMEWILKDVGKR 82

                         90
                 ....*....|....*...
gi 392303278  85 HCHLPELLQTVRLALLPA 102
Cdd:cd18466   83 KKHVVEVLEPVRFPLLPP 100
PHA03098 PHA03098
kelch-like protein; Provisional
 1-254 4.81e-17

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 80.20  E-value: 4.81e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278   1 RNLHPSNCLGMLLLSDAHQCAKLSELSWGMCLSNFPAICKTEDFLQLPKDMVVQLLSHEELETEDERLVYEAALGWLNYD 80
Cdd:PHA03098 103 KIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSDDKLNVSSEDVVLEIIIKWLTSK 182

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278  81 LDGRHCHLPELLQTVRLALLpaiflmenvsTEELINSQARSKelvdEAIRCKLKILQNDGVV-------NSPCARPRKTS 153
Cdd:PHA03098 183 KNNKYKDICLILKVLRITFL----------SEEGIKKLKRWK----LRIKKKKIVFNKRCIKiiyskkyNLNKILPRSST 248

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278 154 HALFLLGGQTFMCDKLYLVDQKAKEIIPKADIPSPRKEFSACA-IGCRVYITGGRGSENGVSKDVWVYDTVHEEWSKAAP 232
Cdd:PHA03098 249 FGSIIYIHITMSIFTYNYITNYSPLSEINTIIDIHYVYCFGSVvLNNVIYFIGGMNKNNLSVNSVVSYDTKTKSWNKVPE 328

                        250       260
                 ....*....|....*....|..
gi 392303278 233 MLIARFGHGSAELKHCLYVVGG 254
Cdd:PHA03098 329 LIYPRKNPGVTVFNNRIYVIGG 350
BACK_KLHL38 cd18476
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs ...
 3-97 5.05e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs to the KLHL family. Its function remains unclear. The klhl38 gene has recently been identified as a possible diapause (a temporary arrest of development during early ontogeny) gene, as it is significantly up-regulated during diapause. It may also be involved in chicken preadipocyte differentiation.


Pssm-ID: 350551 [Multi-domain]  Cd Length: 99  Bit Score: 74.39  E-value: 5.05e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278   3 LHPSNCLGMLLLSDAHQCAKLSELSWGMCLSNFPAICKTEDFLQLPKDMVVQLLSHEELETEDERlVYEAALGWLNYDLD 82
Cdd:cd18476    1 LTPSNCLSMIRLSEILNCETLKKKAKDMALQCFPDVAASEDLKELCASELLDYLGDDELCGEEEQ-VFETLMVWIRHDPK 79

                         90
                 ....*....|....*
gi 392303278  83 GRHCHLPELLQTVRL 97
Cdd:cd18476   80 ARKGYIHDLFKKVRL 94
BACK_KBTBD2 cd18479
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 7-97 1.98e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulating the insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation.


Pssm-ID: 350554 [Multi-domain]  Cd Length: 96  Bit Score: 72.78  E-value: 1.98e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278   7 NCLGMLLLSDAHQCAKLSELSWGMCLSNFPAICKTEDFLQLPKDMVVQLLSHEELETEDERLVYEAALGWLNYDLDGRHC 86
Cdd:cd18479    5 NCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQEAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNTESRSQ 84

                         90
                 ....*....|.
gi 392303278  87 HLPELLQTVRL 97
Cdd:cd18479   85 YLSSVLSQIRI 95
BACK_KLHL19_KEAP1 cd18458
BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); ...
 2-92 5.54e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also termed cytosolic inhibitor of Nrf2 (INrf2), or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.


Pssm-ID: 350533 [Multi-domain]  Cd Length: 91  Bit Score: 68.47  E-value: 5.54e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278   2 NLHPSNCLGMLLLSDAHQCAKLSELSWGMCLSNFPAICKTEDFLQLPKDMVVQLLSHEELETEDERLVYEAALGWLNYDL 81
Cdd:cd18458    1 QLDPSNCIGIANFAEQHGCTELHKKAREYIYMHFSEVSQSEEFFNLSPCQLVALISRDELNVRCESEVYNAVIRWVKYDE 80

                         90
                 ....*....|.
gi 392303278  82 DGRHCHLPELL 92
Cdd:cd18458   81 ENRRQYLEALL 91
BACK_KBTBD8 cd18483
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 3-92 1.81e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor for a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralogue TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome.


Pssm-ID: 350558 [Multi-domain]  Cd Length: 97  Bit Score: 67.19  E-value: 1.81e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278   3 LHPSNCLGMLLLSDAHQCAKLSELSWGMCLSNFPAICKTEDFLQLPKDMVVQLLSHEELETEDERLVYEAALGWLNYDLD 82
Cdd:cd18483    1 LDPQNSIGVFIFADHYGHQELKERSQDYIRKKFLSVTKEQEFLHLTKDQLISILNSDDLNVEKEEHVYESIIHWFEHEQS 80

                         90
                 ....*....|
gi 392303278  83 GRHCHLPELL 92
Cdd:cd18483   81 KREMHLPEIF 90
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
181-260 2.12e-14

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 70.96  E-value: 2.12e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278 181 PKADIPSPRKEFSACAIGCRVYITGGRgSENGVSKDVWVYDTVHEEWSKAAPM-LIARFGHGSAELKHCLYVVGGHTAAT 259
Cdd:COG3055    5 SLPDLPTPRSEAAAALLDGKVYVAGGL-SGGSASNSFEVYDPATNTWSELAPLpGPPRHHAAAVAQDGKLYVFGGFTGAN 83


                 .
gi 392303278 260 G 260
Cdd:COG3055   84 P 84
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
156-259 4.10e-14

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 70.18  E-value: 4.10e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278 156 LFLLGGQTF--MCDKLYLVDQKAKEIIPKADIPSPRKEFSACA-IGCRVYITGGRGSENG---VSKDVWVYDTVHEEWSK 229
Cdd:COG3055   25 VYVAGGLSGgsASNSFEVYDPATNTWSELAPLPGPPRHHAAAVaQDGKLYVFGGFTGANPsstPLNDVYVYDPATNTWTK 104

                         90       100       110
                 ....*....|....*....|....*....|
gi 392303278 230 AAPMLIARFGHGSAELKHCLYVVGGHTAAT 259
Cdd:COG3055  105 LAPMPTPRGGATALLLDGKIYVVGGWDDGG 134
BACK_KEL_like cd18508
BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch ...
 6-80 5.20e-14

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch protein (KEL) and similar proteins; KEL, also termed kelch short protein, is a component of ring canals that regulates the flow of cytoplasm between cells. It binds actin and may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis.


Pssm-ID: 350583 [Multi-domain]  Cd Length: 77  Bit Score: 65.51  E-value: 5.20e-14
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 392303278   6 SNCLGMLLLSDAHQCAKLSELSWGMCLSNFPAICKTEDFLQLPKDMVVQLLSHEELETEDERLVYEAALGWLNYD 80
Cdd:cd18508    3 TNCLGIHEFADAHSCVELEEAAQNYIYQHFNEVIQGEEFLSLDHESLTELISSDRLNVPSEERVYEAAVAWLKHD 77
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 4-58 1.28e-13

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 63.83  E-value: 1.28e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 392303278   4 HPSNCLGMLLLSDAHQCAKLSELSWGMCLSNFPAICKTEDFLQLPKDMVVQLLSH 58
Cdd:cd14733    1 DPENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVELLLELLSS 55
BACK_KLHL24 cd18463
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also ...
 3-79 2.01e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6), or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation.


Pssm-ID: 350538 [Multi-domain]  Cd Length: 78  Bit Score: 63.95  E-value: 2.01e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 392303278   3 LHPSNCLGMLLLSDAHQCAKLSELSWGMCLSNFPAICKTEDFLQLPKDMVVQLLSHEELETEDERLVYEAALGWLNY 79
Cdd:cd18463    2 LDPCNCLGIQKFADTHSLKQLFEKCKKFALENFVEVSQHEEFLELCKDELIEYISNDELVVPKEEEVFEAVMRWVYH 78
BACK_KLHL7 cd18447
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a ...
 6-99 3.38e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a BTB-Kelch protein that constitutes a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 cause autosomal-dominant retinitis pigmentosa.


Pssm-ID: 350522 [Multi-domain]  Cd Length: 98  Bit Score: 63.92  E-value: 3.38e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278   6 SNCLGMLLLSDAHQCAKLSELSWGMCLSNFPAICKTEDFLQLPKDMVVQLLSHEELETEDERLVYEAALGWLNYDLDGRH 85
Cdd:cd18447    5 SNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQ 84

                         90
                 ....*....|....
gi 392303278  86 CHLPELLQTVRLAL 99
Cdd:cd18447   85 PYMVDILAKVRFPL 98
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
156-254 3.99e-13

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 67.49  E-value: 3.99e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278 156 LFLLGG------QTFMCDKLYLVDQKAKEIIPKADIPSPRKEFSACAIGCRVYITGGRgSENGVSKDVWVYDTVHEEWSK 229
Cdd:COG3055   73 LYVFGGftganpSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGW-DDGGNVAWVEVYDPATGTWTQ 151

                         90       100
                 ....*....|....*....|....*.
gi 392303278 230 AAPMLIARFGHGSAEL-KHCLYVVGG 254
Cdd:COG3055  152 LAPLPTPRDHLAAAVLpDGKILVIGG 177
BACK_KLHL28_BTBD5 cd18467
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also ...
 3-100 5.23e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also termed BTB/POZ domain-containing protein 5 (BTBD5), belongs to the KLHL family. Its function remains unclear.


Pssm-ID: 350542 [Multi-domain]  Cd Length: 99  Bit Score: 63.43  E-value: 5.23e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278   3 LHPSNCLGMLLLSDAHQCAKLSELSWGMCLSNFPAICKTEDFLQLPKDMVVQLLSHEELETEDERLVYEAALGWLNYDLD 82
Cdd:cd18467    1 LDPGNCIGISRFAETYGCHDLYLAANKYICQNFEDVCQTEEFFELTHAELDEIVSNDCLNVVTEETVFYALESWIKYDVQ 80

                         90
                 ....*....|....*...
gi 392303278  83 GRHCHLPELLQTVRLALL 100
Cdd:cd18467   81 ERQKYLAQLLHCVRLPLL 98
BACK_KLHL16_gigaxonin cd18455
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ...
 5-100 5.91e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.


Pssm-ID: 350530 [Multi-domain]  Cd Length: 97  Bit Score: 63.10  E-value: 5.91e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278   5 PSNCLGMLLLSDAHQCAKLSELSWGMCLSNFPAICKTEDFLQLPKDMVVQLLSHEELETEDERLVYEAALGWLNYDLDGR 84
Cdd:cd18455    2 AENCIGIRDFAERFSCPHVHYVATEYLETHFRDVSSTEEFLELSPEKLKELLSRDKLNVGNEEYIFEAVLRWVRHDPEER 81

                         90
                 ....*....|....*.
gi 392303278  85 HCHLPELLQTVRLALL 100
Cdd:cd18455   82 KVHLKDLMSSCWRSGL 97
BACK_KLHL40_like cd18477
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The ...
 3-101 1.03e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells.


Pssm-ID: 350552 [Multi-domain]  Cd Length: 99  Bit Score: 62.55  E-value: 1.03e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278   3 LHPSNCLGMLLLSDAHQCAKLSELSWGMCLSNFPAICKTEDFLQLPKDMVVQLLSHEELETEDERLVYEAALGWLNYDLD 82
Cdd:cd18477    1 LCLGNCLAIFRLGLLLDCPRLAVSARDFICAHFTLVAKDEDFLGLSADELIAIISSDGLNVEKEEAVFEAVMKWVREAKE 80

                         90
                 ....*....|....*....
gi 392303278  83 GRHCHLPELLQTVRLALLP 101
Cdd:cd18477   81 NRQKALPTVFESIRFRLLP 99
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
144-260 1.45e-12

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 65.95  E-value: 1.45e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278 144 SPCARPRkTSHALFLLGGqtfmcDKLYLV-----DQKAKEIIPKADIPSPRKEFSACAIGCRVYITGGrgsENGVSKDVW 218
Cdd:COG3055  153 APLPTPR-DHLAAAVLPD-----GKILVIggrngSGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGG---ESGFSDEVE 223

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 392303278 219 VYDTVHEEWSKAAPMLIARFGHGSAELKHCLYVVGGHTAATG 260
Cdd:COG3055  224 AYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGGETKPGV 265
BACK_KLHL23 cd18462
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is ...
 7-99 3.62e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is involved in tumorigenesis and resistance to anticancer drug treatment. It also associates with cone-rod dystrophy.


Pssm-ID: 350537 [Multi-domain]  Cd Length: 102  Bit Score: 61.29  E-value: 3.62e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278   7 NCLGMLLLSDAHQCAKLSELSWGMCLSNFPAICKTEDFLQLPKDMVVQLLSHEELETEDERLVYEAALGWLNYDLDGRHC 86
Cdd:cd18462    5 NCLGMHSFAEFHVCPELEKESRRIILSRFEEVWQQEEFLELSKEKLLYILSRENLNVWKEEVLIEAVVKWVAHDVEKRIE 84

                         90
                 ....*....|...
gi 392303278  87 HLPELLQTVRLAL 99
Cdd:cd18462   85 CAYDLLSSIKLDL 97
BACK_KLHL35 cd18474
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs ...
 6-80 6.69e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm.


Pssm-ID: 350549 [Multi-domain]  Cd Length: 79  Bit Score: 59.83  E-value: 6.69e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 392303278   6 SNCLGMLLLSDAHQCAKLSELSWGMCLSNFPAICKTEDFLQLPKDMVVQLLSHEELETEDERLVYEAALGWLNYD 80
Cdd:cd18474    4 NNCLALLAAADALHCAPLQEHCIRVLLRDFAQAARHPSFLKLELQLVLELLADDSLAVRSEEVVLEAALRWVDAD 78
BACK_KLHL40_KBTBD5 cd18516
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also ...
 6-101 7.85e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5, or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy.


Pssm-ID: 350591 [Multi-domain]  Cd Length: 99  Bit Score: 60.16  E-value: 7.85e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278   6 SNCLGMLLLSDAHQCAKLSELSWGMCLSNFPAICKTEDFLQLPKDMVVQLLSHEELETEDERLVYEAALGWLNYDLDGRH 85
Cdd:cd18516    4 SNCLAIFRLGLLLDCPRLAVAARDFICDRFQLIARDEDFLQLSPDELIAIISSDSLNVEKEEDVFEAVMKWVGKDQEERT 83

                         90
                 ....*....|....*.
gi 392303278  86 CHLPELLQTVRLALLP 101
Cdd:cd18516   84 KALPVLLESIRFRLMP 99
BACK_KLHL33 cd18472
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs ...
 3-77 1.04e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs to the KLHL family. Its function remains unclear. KLHL33 SNPs may be associated with prostate cancer risk.


Pssm-ID: 350547 [Multi-domain]  Cd Length: 75  Bit Score: 59.32  E-value: 1.04e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 392303278   3 LHPSNCLGMLLLSDAHQCAKLSELSWGMCLSNFPAICKTEDFLQLPKDMVVQLLSHEELETEDERLVYEAALGWL 77
Cdd:cd18472    1 LSPANCLELWAFADAATLPRLAAAARAFALKHFAEVAASAAFLSLPLARLLELLRSDELEVAEEEAVFEAAVRWL 75
BACK_KLHL41_KBTBD10 cd18517
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also ...
 3-101 1.68e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also called Kel-like protein 23, or Kelch repeat and BTB domain-containing protein 10, or Kelch-related protein 1 (Krp1), or sarcosine, is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils.


Pssm-ID: 350592 [Multi-domain]  Cd Length: 99  Bit Score: 59.40  E-value: 1.68e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278   3 LHPSNCLGMLLLSDAHQCAKLSELSWGMCLSNFPAICKTEDFLQLPKDMVVQLLSHEELETEDERLVYEAALGWLNYDLD 82
Cdd:cd18517    1 LSVGNCLAIFRLGLLLDCPRLAVSARDFVSDRFEQISKEEDFLQLAPHELIAIISSDSLNVEKEELVFEAVMKWVRTDKE 80

                         90
                 ....*....|....*....
gi 392303278  83 GRHCHLPELLQTVRLALLP 101
Cdd:cd18517   81 NRVKSLGEIFDCIRFRLMP 99
BACK_KLHL22 cd18461
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a ...
 7-100 2.18e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of Polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation.


Pssm-ID: 350536  Cd Length: 104  Bit Score: 59.00  E-value: 2.18e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278   7 NCLGMLLLSDAHQCAKLSELSWGMCLSNFPAICKTEDFLQLPKDMVVQLLSHEELETEDERLVYEAALGWlNYDLD---- 82
Cdd:cd18461    5 NILDVYKLADLFHLTHLSEQLDSYILKNFPTFSRTETYRQLPLEKVYSLLSSNRLEVDSENEVYEGALLY-HYTPEqvek 83

                         90       100
                 ....*....|....*....|
gi 392303278  83 GRHCHL--PELLQTVRLALL 100
Cdd:cd18461   84 DQVSLQepPKLLEAVRFPLM 103
BACK_KLHL10 cd18450
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be ...
 3-80 3.46e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.


Pssm-ID: 350525 [Multi-domain]  Cd Length: 80  Bit Score: 58.01  E-value: 3.46e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 392303278   3 LHPSNCLGMLLLSDAHQCAKLSELSWGMCLSNFPAICK-TEDFLQLPKDMVVQLLSHEELETEDERLVYEAALGWLNYD 80
Cdd:cd18450    1 LTPENCIGIRKFARYYFCPELERKAYRYILRNFEEVAKdSEEFLELSCEELEDIIEDDELNVKEEEVVFEAIVKWIDHD 79
BACK_KLHL21 cd18460
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a ...
 3-97 4.22e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively.


Pssm-ID: 350535 [Multi-domain]  Cd Length: 101  Bit Score: 58.27  E-value: 4.22e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278   3 LHPSNCLGMLLLSDAHQCAKLSELSWGMCLSNFPAICKTEDFLQLPKDMVVQLLSHEELETEDERLVYEAALGWLNYDLD 82
Cdd:cd18460    1 LDVSNCLEMQDFAEAFACRGLAEAAKRFILRHIVELAKGEQFERLPLKRLLEYLSDDGLCVDKEETAYQIALRWVKADPK 80

                         90
                 ....*....|....*
gi 392303278  83 GRHCHLPELLQTVRL 97
Cdd:cd18460   81 HRQHFWPELLQHVRL 95
BACK_KBTBD3 cd18480
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 6-84 7.19e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350555 [Multi-domain]  Cd Length: 82  Bit Score: 56.95  E-value: 7.19e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 392303278   6 SNCLGMLLLSDAHQCAKLSELSWGMCLSNFPAICKTEDFLQLPKDMVVQLLSHEELETEDERLVYEAALGWLNYDLDGR 84
Cdd:cd18480    4 SNCLQLLSFAESYGSTRLLDHALEFVMQHFSLLSQSQEFLELNFEVLEKILEADELNVPDEEAVLKAVLRWTKHDLEAR 82
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 188-233 2.06e-09

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 52.23  E-value: 2.06e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 392303278  188 PRKEFSACAIGCRVYITGGRGSENGVSkDVWVYDTVHEEWSKAAPM 233
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLN-SVEVYDPETNTWSKLPSM 45
BACK_KBTBD12 cd18485
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 3-99 5.45e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also termed Kelch domain-containing protein 6 (KLHDC6), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350560 [Multi-domain]  Cd Length: 100  Bit Score: 49.73  E-value: 5.45e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278   3 LHPSNCLGmLLLSDAHQCAK-LSELSWGMCLSNFPAICKTEDFLQLPKDMVVQLLSHEELETEDERLVYEAALGWLNYDL 81
Cdd:cd18485    1 MDASNCLG-IYYFAKQIGAEdLSDRARKYLYQHFTEVCLHEEVLEIEAHQLLTLIKSDDLNVSREESILDLVLRWVNHNR 79

                         90
                 ....*....|....*...
gi 392303278  82 DGRHCHLPELLQTVRLAL 99
Cdd:cd18485   80 KSRVQHLVELLKQVRLEL 97
Kelch smart00612
Kelch domain;
200-243 8.77e-08

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 47.55  E-value: 8.77e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 392303278   200 RVYITGGRGSENgVSKDVWVYDTVHEEWSKAAPMLIARFGHGSA 243
Cdd:smart00612   1 KIYVVGGFDGGQ-RLKSVEVYDPETNKWTPLPSMPTPRSGHGVA 43
Kelch_4 pfam13418
Galactose oxidase, central domain;
188-233 3.16e-07

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 46.07  E-value: 3.16e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 392303278  188 PRKEFSACAIGC-RVYITGGRGSENGVSKDVWVYDTVHEEWSKAAPM 233
Cdd:pfam13418   1 PRAYHTSTSIPDdTIYLFGGEGEDGTLLSDLWVFDLSTNEWTRLGSL 47
Kelch_6 pfam13964
Kelch motif;
188-237 2.02e-06

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 43.86  E-value: 2.02e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 392303278  188 PRKEFSACAIGCRVYITGGRGSENGVSKDVWVYDTVHEEWSKAAPMLIAR 237
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
BACK_KLHL14 cd18453
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 14 (KLHL14); KLHL14, also ...
 42-111 3.01e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 14 (KLHL14); KLHL14, also termed protein interactor of Torsin-1A, or Printor, or protein interactor of torsinA, is a novel ATP-free form of torsinA-interacting protein implicated in dystonia pathogenesis.


Pssm-ID: 350528  Cd Length: 102  Bit Score: 45.01  E-value: 3.01e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278  42 EDFLQLPKDMVVQLLSHEELETEDERLVYEAALGWLNYDLDGRHCHLPELLQTVRLALLPAIFLMENVST 111
Cdd:cd18453   31 EDVLLLNFEEMRAMLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMKRLRFALIPAPELVERVQS 100
BACK_KLHL11 cd18451
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a ...
 3-90 3.17e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.


Pssm-ID: 350526 [Multi-domain]  Cd Length: 88  Bit Score: 44.57  E-value: 3.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278   3 LHPSNCLGMLLLSDAHQCAKLSELSWGMCLSNFPAICKTEDFLQLPKDMVVQLLSHEELETEDERLVYEAALGWLNYDLD 82
Cdd:cd18451    1 LNLSNCVAIHSLAHMYSLDQLALKAADMIRRNFHKVIQDEEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVLKWVQRNAE 80


                 ....*...
gi 392303278  83 GRHCHLPE 90
Cdd:cd18451   81 ERERYFEE 88
BACK_calicin cd18503
BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal ...
 7-79 3.65e-06

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa.


Pssm-ID: 350578 [Multi-domain]  Cd Length: 78  Bit Score: 43.88  E-value: 3.65e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 392303278   7 NCLGMLLLSDAHQCAKLSELSWGMCLSNFPAICKTEDFLQLPKDMVVQLLSHEELETEDERLVYEAALGWLNY 79
Cdd:cd18503    5 NCLTALCLATTAGLKDLSDEIYDYIRDNFFDVSGTREFLQCPYDIFSRLLKDENLHVNNEDQVLLALLNWTEH 77
BACK_BTBD17 cd18493
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); ...
 17-77 3.81e-06

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also termed galectin-3-binding protein-like, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. It may be involved in hepatocellular carcinoma development and progression.


Pssm-ID: 350568  Cd Length: 74  Bit Score: 43.72  E-value: 3.81e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 392303278  17 AHQCAKLseLSWgmclsNFPAICKTEDFLQLPKDMVVQLLSHEELETEDERLVYEAALGWL 77
Cdd:cd18493   21 AEACLEF--IAW-----NFEKVLKSPDWLNLDLDLLVSLLQSSDLVVEDEYTLFQAVEKWL 74
BACK_KLHL9_13 cd18449
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 ...
 32-98 6.68e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 and KLHL13 (also termed BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.


Pssm-ID: 350524 [Multi-domain]  Cd Length: 95  Bit Score: 43.57  E-value: 6.68e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 392303278  32 LSNFPAICKTEDFLQLPKDMVVQLLSHEELETEDERLVYEAALGWLNYDlDGRHCHLPELLQTVRLA 98
Cdd:cd18449   30 LKNFPALLSTGDFVKLPFERLAFVLSSNSLKGCTELELFKAACRWLRHE-DDRMQFAAKLMENIRFP 95
Kelch_3 pfam13415
Galactose oxidase, central domain;
198-243 7.90e-06

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 42.28  E-value: 7.90e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 392303278  198 GCRVYITGGRGSENG-VSKDVWVYDTVHEEWSKAAPMLIARFGHGSA 243
Cdd:pfam13415   1 GDKLYIFGGLGFDGQtRLNDLYVYDLDTNTWTQIGDLPPPRSGHSAT 47
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 186-222 5.08e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 39.86  E-value: 5.08e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 392303278  186 PSPRKEFSACAIGCRVYITGGR-GSENGVSKDVWVYDT 222
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGYtGGEGQPSDDVYVLSL 38
BACK_NS1BP_IVNS1ABP cd18502
BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); ...
 3-100 1.00e-04

BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); NS1-BP, also called NS1-binding protein, or Aryl hydrocarbon receptor-associated protein 3, or IVNS1ABP, is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control.


Pssm-ID: 350577  Cd Length: 99  Bit Score: 40.30  E-value: 1.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278   3 LHPSNCLGMLLLSDAHQCAKLSELSWGMCLSNFPAICKTEDFLQLPKDMV-VQLLSHEELETEDERLVYEAALGWLNYDL 81
Cdd:cd18502    1 LTPENCIGIRSFAGRMNDSELLQKVDSYIQENIEEVAESKEFLKLPRLQIeVILESNQELESINERKLCQLVLEWVQRSI 80

                         90
                 ....*....|....*....
gi 392303278  82 DGRHCHLPELLQTVRLALL 100
Cdd:cd18502   81 EEGGLDLDDLTEKVHMLYL 99
BACK_KLHL26 cd18465
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a ...
 8-100 1.49e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a kelch family protein encoded by gene klhl26, which is regulated by p53 via fuzzy tandem repeats.


Pssm-ID: 350540  Cd Length: 97  Bit Score: 39.89  E-value: 1.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278   8 CLGMLLLSDAHQCAKLSELSWGMCLSNFPAICKTEDFLQLPKDMVVQLLSHEELETEDERLVYEAALGWLNYDlDGRHCH 87
Cdd:cd18465    6 CLNIGQMATTFSLASLKESVDAFTFRHFLQIAEEEDFLHLPLERLVFFLQSNKLKNCSEIDLFRAAIRWLQHD-PSRRAS 84

                         90
                 ....*....|...
gi 392303278  88 LPELLQTVRLALL 100
Cdd:cd18465   85 ASHVLCHIRFPLM 97
BACK_KLHL31_KBTBD1 cd18470
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also ...
 7-97 4.76e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also termed BTB and kelch domain-containing protein 6, or Kelch repeat and BTB domain-containing protein 1, or Kelch-like protein KLHL, is a transcriptional repressor in MAPK/JNK signaling pathway that regulates cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).


Pssm-ID: 350545  Cd Length: 98  Bit Score: 38.70  E-value: 4.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278   7 NCLGMLLLSDAHQCAKLSELSWGMCLSNFPAICKTEDFLQLPKDMVVQLLSHEELETEDERLVYEAALGWLNYDlDGRHC 86
Cdd:cd18470    5 NCMYVVNIAETYGLKNTKEAAQKFIRDNFIEFSETDQFLKLTFEQINEFLIDDDLQLPSEITAFQIAMKWLDFD-QKRVK 83

                         90
                 ....*....|.
gi 392303278  87 HLPELLQTVRL 97
Cdd:cd18470   84 YAADLLSNIRF 94
BACK_KBTBD6_7 cd18482
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing ...
 6-96 1.43e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing proteins, KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling.


Pssm-ID: 350557 [Multi-domain]  Cd Length: 99  Bit Score: 37.10  E-value: 1.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392303278   6 SNCLGMLLLSDAHQCAKLSELSWGMCLSNF-PAICKTEDFLQLPKDMVVQLLSHEELETEDERLVYEAALGWLNYDLDGR 84
Cdd:cd18482    4 SNCAGILKFADAFDNRELKSKALAFIARNFqQLLAKEEELCELSLAQLKEVLMLDSLDVDSERKVCSVAVQWIEANLKER 83

                         90
                 ....*....|..
gi 392303278  85 HCHLPELLQTVR 96
Cdd:cd18482   84 AASAAEVLKCVR 95
BACK_KLHL36 cd18475
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act ...
 32-101 2.13e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.


Pssm-ID: 350550  Cd Length: 100  Bit Score: 36.74  E-value: 2.13e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 392303278  32 LSNFPAICKTEDFLQ-LPKDMVVQLLSHEELETEDERLVYEAALGWLNYDLDgRHCHLPELLQTVRLALLP 101
Cdd:cd18475   30 LQNFGTLSFTPDFLQnVSMQKLCQYLSSNQVQHECEHDLLQAALQWLTQSPE-RENEAYQVLSNIHFPLIP 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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