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Conserved domains on  [gi|390619918|gb|AFM21065|]
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tRNA(1-methyladenosine) methyltransferase-like methyltransferase [Acetomicrobium mobile DSM 13181]

Protein Classification

tRNA (adenine-N1)-methyltransferase( domain architecture ID 11457537)

tRNA (adenine-N1)-methyltransferase, such as tRNA (adenine(58)-N(1))-methyltransferase, which is a class I SAM-dependent methyltransferase that catalyzes the methylation of N(1)-adenine at position 58 (m1A58) in tRNA using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 7-253 4.19e-125

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


:

Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 355.62  E-value: 4.19e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 390619918   7 AGTLVTLCSaSKKDRFLVTLEDGGKLETRLGIILHDQIMSAGYGGKVLSHNGSVFYVTKPTLEEYLRKIKRRTQIVFPKE 86
Cdd:COG2519    1 EGDRVLLTD-PKGRKYLVRLEEGKKFHTHKGIIDHDDLIGKPEGSVVTTSKGKEFLVLRPTLYDYVLSMKRGTQIIYPKD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 390619918  87 AGYILLQLDIRPGARVLECGTGSGGMTTVFASFVGDEGRVYSYDVREEFIELARRNCRKWRVEQRVSFKVRHISEGFDER 166
Cdd:COG2519   80 AGYIIARLDIFPGARVLEAGTGSGALTLALARAVGPEGKVYSYERREDFAEIARKNLERFGLPDNVELKLGDIREGIDEG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 390619918 167 EVDAVFLDLPDPWNYLPQVRDALALGRRMGALLPTFNQIERFLRSLEENAFVDVEVVEILHRALKSDPDRLRPEDRMIGH 246
Cdd:COG2519  160 DVDAVFLDMPDPWEALEAVAKALKPGGVLVAYVPTVNQVSKLVEALRESGFTDIEAVETLLREWKVEGLAVRPEHRMVGH 239


                 ....*..
gi 390619918 247 TGYLIFA 253
Cdd:COG2519  240 TGFLVFA 246
 
Name Accession Description Interval E-value
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 7-253 4.19e-125

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 355.62  E-value: 4.19e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 390619918   7 AGTLVTLCSaSKKDRFLVTLEDGGKLETRLGIILHDQIMSAGYGGKVLSHNGSVFYVTKPTLEEYLRKIKRRTQIVFPKE 86
Cdd:COG2519    1 EGDRVLLTD-PKGRKYLVRLEEGKKFHTHKGIIDHDDLIGKPEGSVVTTSKGKEFLVLRPTLYDYVLSMKRGTQIIYPKD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 390619918  87 AGYILLQLDIRPGARVLECGTGSGGMTTVFASFVGDEGRVYSYDVREEFIELARRNCRKWRVEQRVSFKVRHISEGFDER 166
Cdd:COG2519   80 AGYIIARLDIFPGARVLEAGTGSGALTLALARAVGPEGKVYSYERREDFAEIARKNLERFGLPDNVELKLGDIREGIDEG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 390619918 167 EVDAVFLDLPDPWNYLPQVRDALALGRRMGALLPTFNQIERFLRSLEENAFVDVEVVEILHRALKSDPDRLRPEDRMIGH 246
Cdd:COG2519  160 DVDAVFLDMPDPWEALEAVAKALKPGGVLVAYVPTVNQVSKLVEALRESGFTDIEAVETLLREWKVEGLAVRPEHRMVGH 239


                 ....*..
gi 390619918 247 TGYLIFA 253
Cdd:COG2519  240 TGFLVFA 246
GCD14 pfam08704
tRNA methyltransferase complex GCD14 subunit; GCD14 is a subunit of the tRNA methyltransferase ...
 62-254 2.62e-36

tRNA methyltransferase complex GCD14 subunit; GCD14 is a subunit of the tRNA methyltransferase complex and is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA.


Pssm-ID: 312288  Cd Length: 242  Bit Score: 129.15  E-value: 2.62e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 390619918   62 YVTKPTLEEYLRKIKRRTQIVFPKEAGYILLQLDIRPGARVLECGTGSGGMTTVFASFVGDEGRVYSYDVREEFIELARR 141
Cdd:pfam08704   4 YVLQPTPELWTLNLPHRTQILYTPDISLITMMLELRPGSVVCESGTGSGSLSHAIIRTVAPTGHLFTFEFHEQRADKARE 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 390619918  142 NCRKWRVEQRVSFKVRHI-SEGFDER---EVDAVFLDLPDPWNYLPQVRDALAL-GRRMGALLPTFNQIERFLRSLEENA 216
Cdd:pfam08704  84 EFREHGIDQLVTVTHRDVcKEGFLTEvsgKADAVFLDLPSPWEAVPHAWKALKVeGGRFCSFSPCIEQVQRTCQALAELG 163

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 390619918  217 FVDVEVVEILHR----------------ALKSDPDRLRPEDRM------------------------IGHTGYLIFAT 254
Cdd:pfam08704 164 FTEISTLEVLLRvydvrtvslpvidlgiDREKENERTRTEGLSnddksednsgnsmlgtalkpmseaVGHTGYLTFAT 241
CbiT TIGR02469
precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; This model recognizes ...
 90-173 8.92e-08

precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; This model recognizes the CbiT methylase which is responsible, in part (along with CbiE), for methylating precorrin-6y (or cobalt-precorrin-6y) at both the 5 and 15 positions as well as the concomitant decarbozylation at C-12. In many organisms, this protein is fused to the CbiE subunit. The fused protein, when found in organisms catalyzing the oxidative version of the cobalamin biosynthesis pathway, is called CobL. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 274148 [Multi-domain]  Cd Length: 124  Bit Score: 49.64  E-value: 8.92e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 390619918   90 ILLQLDIRPGARVLECGTGSGGMTTVFASFVGdEGRVYSYDVREEFIELARRNCRKWRVEQRVSFK--VRHISEGFDErE 167
Cdd:TIGR02469  11 TLAKLRLRPGDVLWDIGAGTGSVTIEAARLVP-NGRVYAIERNPEALDLIERNLRRFGVSNIVIVEgdAPEAPEALLP-D 88


                  ....*.
gi 390619918  168 VDAVFL 173
Cdd:TIGR02469  89 PDAVFV 94
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 101-195 1.11e-07

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 48.97  E-value: 1.11e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 390619918 101 RVLECGTGSGGMTTVFASFVGdeGRVYSYDVREEFIELARRNCRKwRVEQRVSFKVRHISEG--FDEREVDAVFLDLP-- 176
Cdd:cd02440    1 RVLDLGCGTGALALALASGPG--ARVTGVDISPVALELARKAAAA-LLADNVEVLKGDAEELppEADESFDVIISDPPlh 77

                         90       100
                 ....*....|....*....|...
gi 390619918 177 ----DPWNYLPQVRDALALGRRM 195
Cdd:cd02440   78 hlveDLARFLEEARRLLKPGGVL 100
PRK13942 PRK13942
protein-L-isoaspartate O-methyltransferase; Provisional
 94-145 2.06e-07

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 184409  Cd Length: 212  Bit Score: 50.40  E-value: 2.06e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 390619918  94 LDIRPGARVLECGTGSGGMTTVFASFVGDEGRVYSYDVREEFIELARRNCRK 145
Cdd:PRK13942  72 LDLKEGMKVLEIGTGSGYHAAVVAEIVGKSGKVVTIERIPELAEKAKKTLKK 123
 
Name Accession Description Interval E-value
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 7-253 4.19e-125

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 355.62  E-value: 4.19e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 390619918   7 AGTLVTLCSaSKKDRFLVTLEDGGKLETRLGIILHDQIMSAGYGGKVLSHNGSVFYVTKPTLEEYLRKIKRRTQIVFPKE 86
Cdd:COG2519    1 EGDRVLLTD-PKGRKYLVRLEEGKKFHTHKGIIDHDDLIGKPEGSVVTTSKGKEFLVLRPTLYDYVLSMKRGTQIIYPKD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 390619918  87 AGYILLQLDIRPGARVLECGTGSGGMTTVFASFVGDEGRVYSYDVREEFIELARRNCRKWRVEQRVSFKVRHISEGFDER 166
Cdd:COG2519   80 AGYIIARLDIFPGARVLEAGTGSGALTLALARAVGPEGKVYSYERREDFAEIARKNLERFGLPDNVELKLGDIREGIDEG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 390619918 167 EVDAVFLDLPDPWNYLPQVRDALALGRRMGALLPTFNQIERFLRSLEENAFVDVEVVEILHRALKSDPDRLRPEDRMIGH 246
Cdd:COG2519  160 DVDAVFLDMPDPWEALEAVAKALKPGGVLVAYVPTVNQVSKLVEALRESGFTDIEAVETLLREWKVEGLAVRPEHRMVGH 239


                 ....*..
gi 390619918 247 TGYLIFA 253
Cdd:COG2519  240 TGFLVFA 246
GCD14 pfam08704
tRNA methyltransferase complex GCD14 subunit; GCD14 is a subunit of the tRNA methyltransferase ...
 62-254 2.62e-36

tRNA methyltransferase complex GCD14 subunit; GCD14 is a subunit of the tRNA methyltransferase complex and is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA.


Pssm-ID: 312288  Cd Length: 242  Bit Score: 129.15  E-value: 2.62e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 390619918   62 YVTKPTLEEYLRKIKRRTQIVFPKEAGYILLQLDIRPGARVLECGTGSGGMTTVFASFVGDEGRVYSYDVREEFIELARR 141
Cdd:pfam08704   4 YVLQPTPELWTLNLPHRTQILYTPDISLITMMLELRPGSVVCESGTGSGSLSHAIIRTVAPTGHLFTFEFHEQRADKARE 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 390619918  142 NCRKWRVEQRVSFKVRHI-SEGFDER---EVDAVFLDLPDPWNYLPQVRDALAL-GRRMGALLPTFNQIERFLRSLEENA 216
Cdd:pfam08704  84 EFREHGIDQLVTVTHRDVcKEGFLTEvsgKADAVFLDLPSPWEAVPHAWKALKVeGGRFCSFSPCIEQVQRTCQALAELG 163

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 390619918  217 FVDVEVVEILHR----------------ALKSDPDRLRPEDRM------------------------IGHTGYLIFAT 254
Cdd:pfam08704 164 FTEISTLEVLLRvydvrtvslpvidlgiDREKENERTRTEGLSnddksednsgnsmlgtalkpmseaVGHTGYLTFAT 241
PCMT pfam01135
Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);
94-179 6.19e-11

Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT);


Pssm-ID: 395902 [Multi-domain]  Cd Length: 205  Bit Score: 60.46  E-value: 6.19e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 390619918   94 LDIRPGARVLECGTGSGGMTTVFASFVGDEGRVYSYDVREEFIELARRNCRKWRVEQrVSFKVRHISEGFDERE-VDAVF 172
Cdd:pfam01135  69 LELKPGMRVLEIGSGSGYLTACFARMVGEVGRVVSIEHIPELVEIARRNLEKLGLEN-VIVVVGDGRQGWPEFApYDAIH 147

                          90
                  ....*....|..
gi 390619918  173 L-----DLPDPW 179
Cdd:pfam01135 148 VgaaapEIPEAL 159
TrmR COG4122
tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; ...
 89-199 4.68e-10

tRNA 5-hydroxyU34 O-methylase TrmR/YrrM [Translation, ribosomal structure and biogenesis]; tRNA 5-hydroxyU34 O-methylase TrmR/YrrM is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443298  Cd Length: 173  Bit Score: 57.12  E-value: 4.68e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 390619918  89 YILLQLdIRPGaRVLECGTGSGGMTTVFASFVGDEGRVYSYDVREEFIELARRNCRKWRVEQRVSFKV---RHISEGFDE 165
Cdd:COG4122    9 YLLARL-LGAK-RILEIGTGTGYSTLWLARALPDDGRLTTIEIDPERAAIARENFARAGLADRIRLILgdaLEVLPRLAD 86

                         90       100       110
                 ....*....|....*....|....*....|....
gi 390619918 166 REVDAVFLDLpDPWNYLPQVRDALALGRRmGALL 199
Cdd:COG4122   87 GPFDLVFIDA-DKSNYPDYLELALPLLRP-GGLI 118
Pcm COG2518
Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, ...
 84-195 9.21e-10

Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442008 [Multi-domain]  Cd Length: 197  Bit Score: 56.64  E-value: 9.21e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 390619918  84 PKEAGYILLQLDIRPGARVLECGTGSGGMTTVFASFVgdeGRVYSYDVREEFIELARRNCRKWRVEqRVSFKVRHISEGF 163
Cdd:COG2518   52 PYIVARMLEALDLKPGDRVLEIGTGSGYQAAVLARLA---GRVYSVERDPELAERARERLAALGYD-NVTVRVGDGALGW 127

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 390619918 164 DER-EVDAVFL-----DLPDPWnylpqvRDALALGRRM 195
Cdd:COG2518  128 PEHaPFDRIIVtaaapEVPEAL------LEQLAPGGRL 159
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 89-190 5.17e-09

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 53.78  E-value: 5.17e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 390619918  89 YILLQLDIRPGARVLECGTGSGGMTTVFASFVGdeGRVYSYDVREEFIELARRNCRKWRVEQRVSFKVRHISEGFDEREV 168
Cdd:COG2230   42 LILRKLGLKPGMRVLDIGCGWGGLALYLARRYG--VRVTGVTLSPEQLEYARERAAEAGLADRVEVRLADYRDLPADGQF 119

                         90       100
                 ....*....|....*....|....*....
gi 390619918 169 DAVF-------LDLPDPWNYLPQVRDALA 190
Cdd:COG2230  120 DAIVsigmfehVGPENYPAYFAKVARLLK 148
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 90-217 7.03e-09

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 53.07  E-value: 7.03e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 390619918  90 ILLQLDIRPGARVLECGTGSGGMTTVFASfvgDEGRVYSYDVREEFIELARRNCRKWRVeqRVSFKVRHISE-GFDEREV 168
Cdd:COG2226   14 LLAALGLRPGARVLDLGCGTGRLALALAE---RGARVTGVDISPEMLELARERAAEAGL--NVEFVVGDAEDlPFPDGSF 88

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 390619918 169 DAVFL-----DLPDPWNYLPQVRDALALGRRMGALLPTFNQIERFLRSLEENAF 217
Cdd:COG2226   89 DLVISsfvlhHLPDPERALAEIARVLKPGGRLVVVDFSPPDLAELEELLAEAGF 142
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 91-195 8.28e-08

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 50.02  E-value: 8.28e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 390619918  91 LLQLDIRPGARVLECGTGSGGMTTVFAsfvgDEG-RVYSYDVREEFIELARRNCRkwrvEQRVSFKVRHISE-GFDEREV 168
Cdd:COG2227   17 LLARLLPAGGRVLDVGCGTGRLALALA----RRGaDVTGVDISPEALEIARERAA----ELNVDFVQGDLEDlPLEDGSF 88

                         90       100       110
                 ....*....|....*....|....*....|..
gi 390619918 169 DAVFL-----DLPDPWNYLPQVRDALALGRRM 195
Cdd:COG2227   89 DLVICsevleHLPDPAALLRELARLLKPGGLL 120
CbiT TIGR02469
precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; This model recognizes ...
 90-173 8.92e-08

precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; This model recognizes the CbiT methylase which is responsible, in part (along with CbiE), for methylating precorrin-6y (or cobalt-precorrin-6y) at both the 5 and 15 positions as well as the concomitant decarbozylation at C-12. In many organisms, this protein is fused to the CbiE subunit. The fused protein, when found in organisms catalyzing the oxidative version of the cobalamin biosynthesis pathway, is called CobL. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 274148 [Multi-domain]  Cd Length: 124  Bit Score: 49.64  E-value: 8.92e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 390619918   90 ILLQLDIRPGARVLECGTGSGGMTTVFASFVGdEGRVYSYDVREEFIELARRNCRKWRVEQRVSFK--VRHISEGFDErE 167
Cdd:TIGR02469  11 TLAKLRLRPGDVLWDIGAGTGSVTIEAARLVP-NGRVYAIERNPEALDLIERNLRRFGVSNIVIVEgdAPEAPEALLP-D 88


                  ....*.
gi 390619918  168 VDAVFL 173
Cdd:TIGR02469  89 PDAVFV 94
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 96-224 8.98e-08

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 50.11  E-value: 8.98e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 390619918   96 IRPGARVLECGTGSGGMTTVFASFVGDEGRVYSYDVREEFIELARRNCRKWRVEqRVSFKVRHISE--------GFDERE 167
Cdd:pfam13847   1 IDKGMRVLDLGCGTGHLSFELAEELGPNAEVVGIDISEEAIEKARENAQKLGFD-NVEFEQGDIEElpelleddKFDVVI 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 390619918  168 VDAVFLDLPDPWNYLPQVRDALALGRRMgaLLPTFNQIERFLRSLEENAFVDVEVVE 224
Cdd:pfam13847  80 SNCVLNHIPDPDKVLQEILRVLKPGGRL--IISDPDSLAELPAHVKEDSTYYAGCVG 134
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 101-195 1.11e-07

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 48.97  E-value: 1.11e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 390619918 101 RVLECGTGSGGMTTVFASFVGdeGRVYSYDVREEFIELARRNCRKwRVEQRVSFKVRHISEG--FDEREVDAVFLDLP-- 176
Cdd:cd02440    1 RVLDLGCGTGALALALASGPG--ARVTGVDISPVALELARKAAAA-LLADNVEVLKGDAEELppEADESFDVIISDPPlh 77

                         90       100
                 ....*....|....*....|...
gi 390619918 177 ----DPWNYLPQVRDALALGRRM 195
Cdd:cd02440   78 hlveDLARFLEEARRLLKPGGVL 100
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 102-190 1.56e-07

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 48.33  E-value: 1.56e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 390619918  102 VLECGTGSGGMTTVFASFVGdeGRVYSYDVREEFIELARRNCRKWRVeqRVSFKVRHISE-GFDEREVDAVF-------L 173
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGG--ARVTGVDLSPEMLERARERAAEAGL--NVEFVQGDAEDlPFPDGSFDLVVssgvlhhL 76

                          90
                  ....*....|....*..
gi 390619918  174 DLPDPWNYLPQVRDALA 190
Cdd:pfam13649  77 PDPDLEAALREIARVLK 93
PRK13942 PRK13942
protein-L-isoaspartate O-methyltransferase; Provisional
 94-145 2.06e-07

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 184409  Cd Length: 212  Bit Score: 50.40  E-value: 2.06e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 390619918  94 LDIRPGARVLECGTGSGGMTTVFASFVGDEGRVYSYDVREEFIELARRNCRK 145
Cdd:PRK13942  72 LDLKEGMKVLEIGTGSGYHAAVVAEIVGKSGKVVTIERIPELAEKAKKTLKK 123
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 84-173 6.58e-07

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 48.76  E-value: 6.58e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 390619918  84 PKEAGYILLQLDIRPGARVLECGTGSGGMTTVFASFVGdeGRVYSYDVREEFIELARRNCRKWRVEQrVSFKVRHISE-- 161
Cdd:COG0500   12 PGLAALLALLERLPKGGRVLDLGCGTGRNLLALAARFG--GRVIGIDLSPEAIALARARAAKAGLGN-VEFLVADLAEld 88

                         90
                 ....*....|..
gi 390619918 162 GFDEREVDAVFL 173
Cdd:COG0500   89 PLPAESFDLVVA 100
cbiT PRK00377
cobalt-precorrin-6Y C(15)-methyltransferase; Provisional
 91-152 9.31e-07

cobalt-precorrin-6Y C(15)-methyltransferase; Provisional


Pssm-ID: 234740  Cd Length: 198  Bit Score: 48.25  E-value: 9.31e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 390619918  91 LLQLDIRPGARVLECGTGSGGMTTVFASFVGDEGRVYSYDVREEFIELARRNCRKWRVEQRV 152
Cdd:PRK00377  33 LSKLRLRKGDMILDIGCGTGSVTVEASLLVGETGKVYAVDKDEKAINLTRRNAEKFGVLNNI 94
CobL COG2242
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part ...
 90-225 1.47e-06

Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441843 [Multi-domain]  Cd Length: 403  Bit Score: 48.62  E-value: 1.47e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 390619918  90 ILLQLDIRPGARVLECGTGSGGMTtVFASFVGDEGRVYSYDVREEFIELARRNCRKwrveqrvsFKVRHIS-------EG 162
Cdd:COG2242  239 TLAKLALRPGDVLWDIGAGSGSVS-IEAARLAPGGRVYAIERDPERAALIRANARR--------FGVPNVEvvegeapEA 309

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 390619918 163 FDE-REVDAVFL-----DLPDpwnYLPQVRDALALGRRMGALLPTFNQIERFLRSLEENAFvDVEVVEI 225
Cdd:COG2242  310 LADlPDPDAVFIggsggNLPE---ILEACWARLRPGGRLVANAVTLETLALALEALAELGY-GGELVQV 374
pcm PRK00312
protein-L-isoaspartate(D-aspartate) O-methyltransferase;
84-142 3.87e-06

protein-L-isoaspartate(D-aspartate) O-methyltransferase;


Pssm-ID: 178974 [Multi-domain]  Cd Length: 212  Bit Score: 46.35  E-value: 3.87e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 390619918  84 PKEAGYILLQLDIRPGARVLECGTGSGGMTTVFASFVgdeGRVYSYDVREEFIELARRN 142
Cdd:PRK00312  64 PYMVARMTELLELKPGDRVLEIGTGSGYQAAVLAHLV---RRVFSVERIKTLQWEAKRR 119
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
65-172 4.10e-06

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 46.44  E-value: 4.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 390619918  65 KPTLEEYLRKIKRRTQIVFPKE--------AGYIL----LQLDIrPGARVLECGTGSGgMTTVFASFVGDEgRVYSYDVR 132
Cdd:COG2263    1 KRELEIILEKLPGFSNPKVELEqyptpaelAAELLhlayLRGDI-EGKTVLDLGCGTG-MLAIGAALLGAK-KVVGVDID 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 390619918 133 EEFIELARRNCRkwRVEQRVSFKVRHISEGFDEREVDAVF 172
Cdd:COG2263   78 PEALEIARENAE--RLGVRVDFIRADVTRIPLGGSVDTVV 115
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
98-199 5.89e-06

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 44.04  E-value: 5.89e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 390619918  98 PGARVLECGTGSGGMTTVFASFVGDeGRVYSYDVREEFIELARRNCrkwrveQRVSFKVRHISEGFDEREVDAVFLD--- 174
Cdd:COG4106    1 PPRRVLDLGCGTGRLTALLAERFPG-ARVTGVDLSPEMLARARARL------PNVRFVVADLRDLDPPEPFDLVVSNaal 73

                         90       100
                 ....*....|....*....|....*..
gi 390619918 175 --LPDPWNYLPQVRDALALGrrmGALL 199
Cdd:COG4106   74 hwLPDHAALLARLAAALAPG---GVLA 97
PRK14968 PRK14968
putative methyltransferase; Provisional
 84-183 2.33e-05

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 44.12  E-value: 2.33e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 390619918  84 PKEAGYILLQ-LDIRPGARVLECGTGSGgmtTVFASFVGDEGRVYSYDVREEFIELARRNCRKWRVEQR-VSFKVRHISE 161
Cdd:PRK14968   8 PAEDSFLLAEnAVDKKGDRVLEVGTGSG---IVAIVAAKNGKKVVGVDINPYAVECAKCNAKLNNIRNNgVEVIRSDLFE 84

                         90       100
                 ....*....|....*....|..
gi 390619918 162 GFDEREVDAVFLDLPdpwnYLP 183
Cdd:PRK14968  85 PFRGDKFDVILFNPP----YLP 102
arsM PRK11873
arsenite methyltransferase;
96-159 3.53e-05

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 44.17  E-value: 3.53e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 390619918  96 IRPGARVLECGTGSGGMTTVFASFVGDEGRVYSYDVREEFIELARRNCRKWRVEQrVSFKVRHI 159
Cdd:PRK11873  75 LKPGETVLDLGSGGGFDCFLAARRVGPTGKVIGVDMTPEMLAKARANARKAGYTN-VEFRLGEI 137
PRK08317 PRK08317
hypothetical protein; Provisional
 94-141 7.92e-05

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 43.00  E-value: 7.92e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 390619918  94 LDIRPGARVLECGTGSGGMTTVFASFVGDEGRVYSYDVREEFIELARR 141
Cdd:PRK08317  15 LAVQPGDRVLDVGCGPGNDARELARRVGPEGRVVGIDRSEAMLALAKE 62
PRK13943 PRK13943
protein-L-isoaspartate O-methyltransferase; Provisional
 84-149 3.02e-04

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 237568 [Multi-domain]  Cd Length: 322  Bit Score: 41.37  E-value: 3.02e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 390619918  84 PKEAGYILLQLDIRPGARVLECGTGSGGMTTVFASFVGDEGRVYSYDVREEFIELARRNCRKWRVE 149
Cdd:PRK13943  66 PSLMALFMEWVGLDKGMRVLEIGGGTGYNAAVMSRVVGEKGLVVSVEYSRKICEIAKRNVRRLGIE 131
COG4798 COG4798
Predicted methyltransferase [General function prediction only];
94-146 1.87e-03

Predicted methyltransferase [General function prediction only];


Pssm-ID: 443826  Cd Length: 274  Bit Score: 38.75  E-value: 1.87e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 390619918  94 LDIRPGARVLECGTGSGGMTTVFASFVGDEGRVY--SYDVREEFIELARRNCRKW 146
Cdd:COG4798   62 FGVKPGMTVVEIWPGGGWYTEILAPYLGPKGKVYaaNFDPDSEPPEYAKRSREAF 116
PRK13944 PRK13944
protein-L-isoaspartate O-methyltransferase; Provisional
 97-142 2.06e-03

protein-L-isoaspartate O-methyltransferase; Provisional


Pssm-ID: 140001  Cd Length: 205  Bit Score: 38.26  E-value: 2.06e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 390619918  97 RPGARVLECGTGSGGMTTVFASFVGDEGRVYSYDVREEFIELARRN 142
Cdd:PRK13944  71 RPGMKILEVGTGSGYQAAVCAEAIERRGKVYTVEIVKELAIYAAQN 116
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 90-154 5.16e-03

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 37.44  E-value: 5.16e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 390619918  90 ILLQLDIRPGARVLECGTGSGGMTTVFASFVGDEgRVYSYDVREEFIELARRNCRKWRVEQRVSF 154
Cdd:COG2890  104 ALALLPAGAPPRVLDLGTGSGAIALALAKERPDA-RVTAVDISPDALAVARRNAERLGLEDRVRF 167
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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