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Conserved domains on  [gi|389570745|gb|AFK87150|]
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putative transmembrane anti-sigma factor [Thermoanaerobacterium saccharolyticum JW/SL-YS485]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF4349 pfam14257
Domain of unknown function (DUF4349); This family of proteins is found in bacteria and archaea. ...
 162-371 6.33e-56

Domain of unknown function (DUF4349); This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 282 and 353 amino acids in length. There is a single completely conserved residue D that may be functionally important. The N-terminus contains a lipoprotein signal peptide sequence.


:

Pssm-ID: 464117 [Multi-domain]  Cd Length: 213  Bit Score: 182.36  E-value: 6.33e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389570745  162 RKITKDAAISIEMNSVDEGYNKILNISKQYNGYIESTSESTSESGQKTVNIVLKIPADDFEYAISNIKSLGDVKMIRINS 241
Cdd:pfam14257   1 RKLIYTASLTLEVEDVDAAAASVRAIVEEAGGYVESSSTSGTDGGERSASLTLRVPADRFDAFLDELAGLGTVTSRSISA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389570745  242 SDITEQYYDVQTRIKNLEIQEESLQNLMKKASNISDILQIEDKLNDVQTQIDSYKSQIKLWDSMTDMSTINLTFLSALPQ 321
Cdd:pfam14257  81 EDVTEQYVDLEARLKALRASEDRLLALLERAGSVEDLLAVERELSEVQAELESLEGQLRYLDDQVAYSTVTLTLTEPEAA 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 389570745  322 AGIDkifSENFFKDVLDAGAKSLNVFFEFIKYAIVMIIYLLPFAILIYLI 371
Cdd:pfam14257 161 TPEE---EPTFGEGFLDALSGGWNALVAFLRGLLVVLGALLPWLLVLALV 207
RsiW COG5662
Transmembrane transcriptional regulator RsiW (anti-sigma-W factor) [Transcription];
1-90 3.75e-11

Transmembrane transcriptional regulator RsiW (anti-sigma-W factor) [Transcription];


:

Pssm-ID: 444381 [Multi-domain]  Cd Length: 155  Bit Score: 61.02  E-value: 3.75e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389570745   1 MECYAVRRLLNPYIDEELDEKSMDDVRAHLDSCEECKLEYNELLYTKRLLENT--PPLELPDNFGETLHIKLiegrknnR 78
Cdd:COG5662    1 MTCDDVEELLHAYLDGELSPEERAEVEAHLATCPACAARLAELRRLRAALRAAlaPDEPVPARLRARVMARL-------P 73

                         90
                 ....*....|..
gi 389570745  79 RKPIKRMISVAA 90
Cdd:COG5662   74 RRRRRRWRAVAA 85
 
Name Accession Description Interval E-value
DUF4349 pfam14257
Domain of unknown function (DUF4349); This family of proteins is found in bacteria and archaea. ...
 162-371 6.33e-56

Domain of unknown function (DUF4349); This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 282 and 353 amino acids in length. There is a single completely conserved residue D that may be functionally important. The N-terminus contains a lipoprotein signal peptide sequence.


Pssm-ID: 464117 [Multi-domain]  Cd Length: 213  Bit Score: 182.36  E-value: 6.33e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389570745  162 RKITKDAAISIEMNSVDEGYNKILNISKQYNGYIESTSESTSESGQKTVNIVLKIPADDFEYAISNIKSLGDVKMIRINS 241
Cdd:pfam14257   1 RKLIYTASLTLEVEDVDAAAASVRAIVEEAGGYVESSSTSGTDGGERSASLTLRVPADRFDAFLDELAGLGTVTSRSISA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389570745  242 SDITEQYYDVQTRIKNLEIQEESLQNLMKKASNISDILQIEDKLNDVQTQIDSYKSQIKLWDSMTDMSTINLTFLSALPQ 321
Cdd:pfam14257  81 EDVTEQYVDLEARLKALRASEDRLLALLERAGSVEDLLAVERELSEVQAELESLEGQLRYLDDQVAYSTVTLTLTEPEAA 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 389570745  322 AGIDkifSENFFKDVLDAGAKSLNVFFEFIKYAIVMIIYLLPFAILIYLI 371
Cdd:pfam14257 161 TPEE---EPTFGEGFLDALSGGWNALVAFLRGLLVVLGALLPWLLVLALV 207
RsiW COG5662
Transmembrane transcriptional regulator RsiW (anti-sigma-W factor) [Transcription];
1-90 3.75e-11

Transmembrane transcriptional regulator RsiW (anti-sigma-W factor) [Transcription];


Pssm-ID: 444381 [Multi-domain]  Cd Length: 155  Bit Score: 61.02  E-value: 3.75e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389570745   1 MECYAVRRLLNPYIDEELDEKSMDDVRAHLDSCEECKLEYNELLYTKRLLENT--PPLELPDNFGETLHIKLiegrknnR 78
Cdd:COG5662    1 MTCDDVEELLHAYLDGELSPEERAEVEAHLATCPACAARLAELRRLRAALRAAlaPDEPVPARLRARVMARL-------P 73

                         90
                 ....*....|..
gi 389570745  79 RKPIKRMISVAA 90
Cdd:COG5662   74 RRRRRRWRAVAA 85
zf-HC2 pfam13490
Putative zinc-finger; This is a putative zinc-finger found in some anti-sigma factor proteins.
 3-36 2.77e-09

Putative zinc-finger; This is a putative zinc-finger found in some anti-sigma factor proteins.


Pssm-ID: 463895 [Multi-domain]  Cd Length: 35  Bit Score: 52.16  E-value: 2.77e-09
                          10        20        30
                  ....*....|....*....|....*....|....
gi 389570745    3 CYAVRRLLNPYIDEELDEKSMDDVRAHLDSCEEC 36
Cdd:pfam13490   1 CEEVRELLSAYLDGELSPEERARVEAHLAGCPAC 34
anti_SigH_actin TIGR02949
anti-sigma factor, TIGR02949 family; This group of anti-sigma factors are associated in an ...
 3-40 2.22e-04

anti-sigma factor, TIGR02949 family; This group of anti-sigma factors are associated in an apparent operon with a family of sigma-70 family sigma factors (TIGR02947). They and appear by homology, tree building, bidirectional best hits and one-to-a-genome distribution, to represent a conserved family. This family is restricted to the Actinobacteria. [Transcription, Transcription factors]


Pssm-ID: 188261  Cd Length: 84  Bit Score: 39.74  E-value: 2.22e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 389570745    3 CYAVRRLLNPYIDEELDEKSMDDVRAHLDSCEECKLEY 40
Cdd:TIGR02949   9 CAEVIDHLYEFLDGECTEDDAERLRRHLAACPECLREY 46
 
Name Accession Description Interval E-value
DUF4349 pfam14257
Domain of unknown function (DUF4349); This family of proteins is found in bacteria and archaea. ...
 162-371 6.33e-56

Domain of unknown function (DUF4349); This family of proteins is found in bacteria and archaea. Proteins in this family are typically between 282 and 353 amino acids in length. There is a single completely conserved residue D that may be functionally important. The N-terminus contains a lipoprotein signal peptide sequence.


Pssm-ID: 464117 [Multi-domain]  Cd Length: 213  Bit Score: 182.36  E-value: 6.33e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389570745  162 RKITKDAAISIEMNSVDEGYNKILNISKQYNGYIESTSESTSESGQKTVNIVLKIPADDFEYAISNIKSLGDVKMIRINS 241
Cdd:pfam14257   1 RKLIYTASLTLEVEDVDAAAASVRAIVEEAGGYVESSSTSGTDGGERSASLTLRVPADRFDAFLDELAGLGTVTSRSISA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389570745  242 SDITEQYYDVQTRIKNLEIQEESLQNLMKKASNISDILQIEDKLNDVQTQIDSYKSQIKLWDSMTDMSTINLTFLSALPQ 321
Cdd:pfam14257  81 EDVTEQYVDLEARLKALRASEDRLLALLERAGSVEDLLAVERELSEVQAELESLEGQLRYLDDQVAYSTVTLTLTEPEAA 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 389570745  322 AGIDkifSENFFKDVLDAGAKSLNVFFEFIKYAIVMIIYLLPFAILIYLI 371
Cdd:pfam14257 161 TPEE---EPTFGEGFLDALSGGWNALVAFLRGLLVVLGALLPWLLVLALV 207
RsiW COG5662
Transmembrane transcriptional regulator RsiW (anti-sigma-W factor) [Transcription];
1-90 3.75e-11

Transmembrane transcriptional regulator RsiW (anti-sigma-W factor) [Transcription];


Pssm-ID: 444381 [Multi-domain]  Cd Length: 155  Bit Score: 61.02  E-value: 3.75e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389570745   1 MECYAVRRLLNPYIDEELDEKSMDDVRAHLDSCEECKLEYNELLYTKRLLENT--PPLELPDNFGETLHIKLiegrknnR 78
Cdd:COG5662    1 MTCDDVEELLHAYLDGELSPEERAEVEAHLATCPACAARLAELRRLRAALRAAlaPDEPVPARLRARVMARL-------P 73

                         90
                 ....*....|..
gi 389570745  79 RKPIKRMISVAA 90
Cdd:COG5662   74 RRRRRRWRAVAA 85
YlaD COG5660
Anti-sigma-YlaC factor YlaD, contains Zn-finger domain [Signal transduction mechanisms];
1-103 8.06e-11

Anti-sigma-YlaC factor YlaD, contains Zn-finger domain [Signal transduction mechanisms];


Pssm-ID: 444379 [Multi-domain]  Cd Length: 219  Bit Score: 61.33  E-value: 8.06e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 389570745   1 MECYAVRRLLNPYIDEELDEKSMDDVRAHLDSCEECKLEYNELLYTKRLLENTPPLELPDnfgetLHIKLIEG--RKNNR 78
Cdd:COG5660    1 MDCETCREALSARLDGELEPVPAAEVDAHLAGCPACRAWLERAAALTRRLRTRPAPEVPD-----LTDAILAAapPAFPR 75

                         90       100
                 ....*....|....*....|....*
gi 389570745  79 RKPIKRmisvAAFAVASIFALSFGF 103
Cdd:COG5660   76 RRAYLR----LALALVALAQLALGL 96
zf-HC2 pfam13490
Putative zinc-finger; This is a putative zinc-finger found in some anti-sigma factor proteins.
 3-36 2.77e-09

Putative zinc-finger; This is a putative zinc-finger found in some anti-sigma factor proteins.


Pssm-ID: 463895 [Multi-domain]  Cd Length: 35  Bit Score: 52.16  E-value: 2.77e-09
                          10        20        30
                  ....*....|....*....|....*....|....
gi 389570745    3 CYAVRRLLNPYIDEELDEKSMDDVRAHLDSCEEC 36
Cdd:pfam13490   1 CEEVRELLSAYLDGELSPEERARVEAHLAGCPAC 34
anti_SigH_actin TIGR02949
anti-sigma factor, TIGR02949 family; This group of anti-sigma factors are associated in an ...
 3-40 2.22e-04

anti-sigma factor, TIGR02949 family; This group of anti-sigma factors are associated in an apparent operon with a family of sigma-70 family sigma factors (TIGR02947). They and appear by homology, tree building, bidirectional best hits and one-to-a-genome distribution, to represent a conserved family. This family is restricted to the Actinobacteria. [Transcription, Transcription factors]


Pssm-ID: 188261  Cd Length: 84  Bit Score: 39.74  E-value: 2.22e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 389570745    3 CYAVRRLLNPYIDEELDEKSMDDVRAHLDSCEECKLEY 40
Cdd:TIGR02949   9 CAEVIDHLYEFLDGECTEDDAERLRRHLAACPECLREY 46
antisig_RsrA TIGR03988
mycothiol system anti-sigma-R factor; Members of this family are the anti-sigma-R factor RsrA, ...
 2-40 2.96e-03

mycothiol system anti-sigma-R factor; Members of this family are the anti-sigma-R factor RsrA, which contains a CXXC motif as a thiol-disulphide redox switch. It interacts with sigma-R. It regulates and is regulated by the mycothiol system, which occurs in many actinomycetes. [Transcription, Transcription factors]


Pssm-ID: 274904  Cd Length: 77  Bit Score: 36.13  E-value: 2.96e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 389570745    2 ECYAVRRLLNPYIDEELDEKSMDDVRAHLDSCEECKLEY 40
Cdd:TIGR03988   1 DCSEVLAEVYEYLDGELDDEDCARLRAHLDECPPCLEQY 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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